bupropion and Complications, Pregnancy studies

Bupropion: A propiophenone-derived antidepressant and antismoking agent that inhibits the uptake of DOPAMINE.
bupropion : An aromatic ketone that is propiophenone carrying a tert-butylamino group at position 2 and a chloro substituent at position 3 on the phenyl ring.

Research Excerpts

Excerpt	Relevance	Reference
"We searched MEDLINE, EMBASE, CINAHL, and PsychINFO databases for studies of any design reporting pregnancy outcomes after bupropion or varenicline exposure."	9.01	Systematic Review and Meta-Analysis to Assess the Safety of Bupropion and Varenicline in Pregnancy. ( Coleman, T; Jones, M; Turner, E; Vaz, LR, 2019)
"To evaluate data on birth outcomes following bupropion use during pregnancy."	8.95	Bupropion Use During Pregnancy: A Systematic Review. ( Gitlin, MJ; Hendrick, V; Ortiz-Portillo, E; Suri, R, 2017)
"Bupropion is used for treatment of depression during pregnancy."	7.83	Bupropion therapy during pregnancy: the drug and its major metabolites in umbilical cord plasma and amniotic fluid. ( Ahmed, MS; Clark, SM; Fokina, VM; Hankins, GD; Nanovskaya, TN; Oncken, C; West, H, 2016)
"Bupropion's efficacy for smoking cessation in pregnant women is unknown."	5.14	The relationship between antidepressant use and smoking cessation in pregnant women in treatment for substance abuse. ( Brigham, EP; Chisolm, MS; Jones, HE; Strain, EC; Tuten, M, 2010)
" When used by non-pregnant smokers, pharmacotherapies (nicotine replacement therapy (NRT), bupropion, and varenicline) are effective for increasing smoking cessation, however their efficacy and safety in pregnancy remains unknown."	5.05	Pharmacological interventions for promoting smoking cessation during pregnancy. ( Berlin, I; Chamberlain, C; Claire, R; Coleman, T; Cooper, SE; Davey, MA; Leonardi-Bee, J, 2020)
"We searched MEDLINE, EMBASE, CINAHL, and PsychINFO databases for studies of any design reporting pregnancy outcomes after bupropion or varenicline exposure."	5.01	Systematic Review and Meta-Analysis to Assess the Safety of Bupropion and Varenicline in Pregnancy. ( Coleman, T; Jones, M; Turner, E; Vaz, LR, 2019)
"To evaluate data on birth outcomes following bupropion use during pregnancy."	4.95	Bupropion Use During Pregnancy: A Systematic Review. ( Gitlin, MJ; Hendrick, V; Ortiz-Portillo, E; Suri, R, 2017)
"To determine the efficacy and safety of smoking cessation pharmacotherapies (including NRT, varenicline and bupropion), other medications, or ENDS when used for smoking cessation in pregnancy."	4.91	Pharmacological interventions for promoting smoking cessation during pregnancy. ( Chamberlain, C; Coleman, T; Cooper, SE; Davey, MA; Leonardi-Bee, J, 2015)
"Cochrane systematic review evidence from 2013 suggests that adding mood management to behavioural support may improve cessation outcomes in smokers with current or past depression and strengthens evidence for previous conclusions, including the safety of varenicline and bupropion and the benefits of behavioural support for smoking cessation in pregnancy."	4.90	Efficacy of interventions to combat tobacco addiction: Cochrane update of 2013 reviews. ( Cahill, K; Hartmann-Boyce, J; Lancaster, T; Stead, LF, 2014)
"Pregnant smokers recruited to participate in a placebo-controlled trial of bupropion for smoking cessation provided a blood sample for measurement of NMR."	3.96	Pregnant Smokers Receiving Opioid Agonist Therapy Have an Elevated Nicotine Metabolite Ratio: A Replication Study. ( Hand, D; Kranzler, HR; Lynch, KG; Oncken, C; Schnoll, R; Tyndale, RF; Washio, Y; Zindel, LR, 2020)
"Bupropion is used for treatment of depression during pregnancy."	3.83	Bupropion therapy during pregnancy: the drug and its major metabolites in umbilical cord plasma and amniotic fluid. ( Ahmed, MS; Clark, SM; Fokina, VM; Hankins, GD; Nanovskaya, TN; Oncken, C; West, H, 2016)
"When considering treating perinatal depression with a drug indicated for the treatment of depression, the major concerns are whether the drug increases the risks of teratogenicity, pregnancy complications, poor neonatal adaptation, or neurodevelopmental disorders."	2.58	Pharmacotherapy for Perinatal Depression. ( Albertini, ES; Ernst, C; Fersh, ME; Habib, S; Khan, SJ; Lusskin, SI, 2018)
" A few minor adverse effects and serious adverse effects were reported in several studies."	2.48	Efficacy and safety of pharmacotherapy for smoking cessation among pregnant smokers: a meta-analysis. ( Ju, W; Jung, HS; Kim, H; Myung, SK; Oh, SW; Park, CH; Seo, H, 2012)
" Neonatal providers should be aware of maternal medications and prepare for possible adverse effects, particularly from common psychotropic exposures."	1.62	Why the Maternal Medication List Matters: Neonatal Toxicity From Combined Serotonergic Exposures. ( Brajcich, MR; Marks, J; Messer, RD; Murphy, ME; Palau, MA, 2021)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	8 (29.63)	29.6817
2010's	14 (51.85)	24.3611
2020's	5 (18.52)	2.80

Trial	Phase	Enrollment	Study Type	Start Date	Status
The Relative Efficacy of Aerobic Exercise in the Treatment of Adults With Attention Deficit Hyperactivity Disorder (ADHD) Versus Medication Only and the Combination of the Two: A Pilot Study[NCT02788851]		70 participants (Anticipated)	Interventional	2016-04-30	Active, not recruiting
Assessment of the Effectiveness of Nicotine Replacement Therapies (Nicotine Patches Delivering Nicotine 16 h/24 h) in 400 Pregnant Smokers. Randomized, Placebo-controlled, Multicenter, National Study. The SNIPP.[NCT00507975]	Phase 3	404 participants (Actual)	Interventional	2007-11-30	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
Pharmacological interventions for promoting smoking cessation during pregnancy. The Cochrane database of systematic reviews, 2020, 03-04, Volume: 3 Topics: Bupropion; Female; Humans; Nicotinic Agonists; Pregnancy; Pregnancy Complications; Pregnancy Outcome	2020
Interventions for Tobacco Smoking Cessation in Adults, Including Pregnant Persons. American family physician, 2021, 06-15, Volume: 103, Issue:12 Topics: Adult; Anxiety Disorders; Bupropion; Counseling; Female; Humans; Pregnancy; Pregnancy Complications;	2021
Bupropion Use During Pregnancy: A Systematic Review. The primary care companion for CNS disorders, 2017, Sep-21, Volume: 19, Issue:5 Topics: Abortion, Spontaneous; Bupropion; Dopamine Uptake Inhibitors; Female; Humans; Pregnancy; Pregnancy C	2017
Pharmacotherapy for Perinatal Depression. Clinical obstetrics and gynecology, 2018, Volume: 61, Issue:3 Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Antidepressive Agents, Tricyclic; Autism Spectru	2018
Systematic Review and Meta-Analysis to Assess the Safety of Bupropion and Varenicline in Pregnancy. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2019, 07-17, Volume: 21, Issue:8 Topics: Bupropion; Case-Control Studies; Female; Humans; Nicotinic Agonists; Pregnancy; Pregnancy Complicati	2019
Pharmaceutical strategies for smoking cessation during pregnancy. Expert opinion on pharmacotherapy, 2018, Volume: 19, Issue:18 Topics: Bupropion; Female; Humans; Pregnancy; Pregnancy Complications; Smoking; Smoking Cessation; Tobacco U	2018
Cochrane review summary: Pharmacological interventions for promoting smoking cessation during pregnancy. Primary health care research & development, 2013, Volume: 14, Issue:4 Topics: Antidepressive Agents, Second-Generation; Benzazepines; Birth Weight; Bupropion; Female; Humans; Inf	2013
Efficacy of interventions to combat tobacco addiction: Cochrane update of 2013 reviews. Addiction (Abingdon, England), 2014, Volume: 109, Issue:9 Topics: Antidepressive Agents, Second-Generation; Behavior Therapy; Benzazepines; Bupropion; Counseling; Fem	2014
Pharmacological interventions for promoting smoking cessation during pregnancy. The Cochrane database of systematic reviews, 2015, Dec-22, Issue:12 Topics: Bupropion; Female; Humans; Nicotinic Agonists; Pregnancy; Pregnancy Complications; Pregnancy Outcome	2015
Smoking cessation in pregnancy. Expert opinion on drug safety, 2008, Volume: 7, Issue:6 Topics: Animals; Benzazepines; Bupropion; Dopamine Uptake Inhibitors; Female; Humans; Nicotine; Nicotinic Ag	2008
Are nicotine replacement therapy, varenicline or bupropion options for pregnant mothers to quit smoking? Effects on the respiratory system of the offspring. Therapeutic advances in respiratory disease, 2009, Volume: 3, Issue:4 Topics: Animals; Antioxidants; Benzazepines; Bupropion; Dopamine Uptake Inhibitors; Female; Humans; Maternal	2009
Efficacy and safety of pharmacotherapy for smoking cessation among pregnant smokers: a meta-analysis. BJOG : an international journal of obstetrics and gynaecology, 2012, Volume: 119, Issue:9 Topics: Adult; Benzazepines; Bupropion; Controlled Clinical Trials as Topic; Dopamine Uptake Inhibitors; Epi	2012
Pharmacotherapy for smoking cessation during pregnancy. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2004, Volume: 6 Suppl 2 Topics: Adult; Bupropion; Dopamine Uptake Inhibitors; Female; Ganglionic Stimulants; Humans; Nicotine; Pregn	2004
Pharmacotherapy of smoking cessation. Archives of family medicine, 2000, Volume: 9, Issue:3 Topics: Administration, Cutaneous; Administration, Inhalation; Antidepressive Agents, Second-Generation; Bup	2000

Article	Year
Pregnant Smokers Receiving Opioid Agonist Therapy Have an Elevated Nicotine Metabolite Ratio: A Replication Study. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2020, 10-08, Volume: 22, Issue:10 Topics: Analgesics, Opioid; Bupropion; Cotinine; Female; Humans; Methadone; Nicotine; Opiate Substitution Tr	2020
Maternal Use of Specific Antidepressant Medications During Early Pregnancy and the Risk of Selected Birth Defects. JAMA psychiatry, 2020, 12-01, Volume: 77, Issue:12 Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Bupropion; Case-Control Studies; Child; Female; Huma	2020
Why the Maternal Medication List Matters: Neonatal Toxicity From Combined Serotonergic Exposures. Pediatrics, 2021, Volume: 147, Issue:2 Topics: Antidepressive Agents; Bipolar Disorder; Brain Diseases; Bupropion; Drug Therapy, Combination; Dyski	2021
ADHD and pregnancy. The American journal of psychiatry, 2014, Volume: 171, Issue:7 Topics: Adult; Attention Deficit Disorder with Hyperactivity; Bupropion; Central Nervous System Stimulants;	2014
Behavioral and Pharmacotherapy Interventions for Tobacco Smoking Cessation in Adults, Including Pregnant Women. American family physician, 2016, May-15, Volume: 93, Issue:10 Topics: Adult; Behavior Therapy; Bupropion; Counseling; Female; Humans; Pregnancy; Pregnancy Complications;	2016
Behavioral and Pharmacotherapy Interventions for Tobacco Smoking Cessation in Adults, Including Pregnant Women: Recommendation Statement. American family physician, 2016, May-15, Volume: 93, Issue:10 Topics: Adult; Behavior Therapy; Bupropion; Combined Modality Therapy; Counseling; Electronic Nicotine Deliv	2016
Bupropion therapy during pregnancy: the drug and its major metabolites in umbilical cord plasma and amniotic fluid. American journal of obstetrics and gynecology, 2016, Volume: 215, Issue:4 Topics: Adult; Amniotic Fluid; Antidepressive Agents, Second-Generation; Bupropion; Depression; Female; Feta	2016
What's new in nicotine & tobacco research? Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2008, Volume: 10, Issue:6 Topics: Adolescent; Adolescent Behavior; Adult; Bupropion; Female; Humans; Male; Pregnancy; Pregnancy Compli	2008
Patterns of antidepressant medication use among pregnant women in a United States population. Journal of clinical pharmacology, 2011, Volume: 51, Issue:2 Topics: Antidepressive Agents; Bupropion; Case-Control Studies; Female; Humans; Pregnancy; Pregnancy Complic	2011
Suicide in pregnancy. Obstetrics and gynecology, 2003, Volume: 102, Issue:6 Topics: Adult; Antidepressive Agents, Second-Generation; Bipolar Disorder; Bupropion; Female; Humans; Pregna	2003
Effectiveness of bupropion for smoking cessation during pregnancy. Journal of addictive diseases, 2005, Volume: 24, Issue:2 Topics: Adult; Bupropion; Dopamine Uptake Inhibitors; Female; Humans; Pregnancy; Pregnancy Complications; Se	2005
Stat bite: Medicaid coverage of tobacco-dependence treatments. Journal of the National Cancer Institute, 2008, Apr-02, Volume: 100, Issue:7 Topics: Administration, Cutaneous; Administration, Intranasal; Administration, Oral; Antidepressive Agents,	2008

bupropion and Complications, Pregnancy

Research Excerpts

Research

Studies (27)

Authors

Clinical Trials (2)

Trial Overview

Reviews

Trials

Other Studies

Authors	Studies
Claire, R	1
Chamberlain, C	2
Davey, MA	2
Cooper, SE	2
Berlin, I	1
Leonardi-Bee, J	2
Coleman, T	3
Kranzler, HR	1
Washio, Y	1
Zindel, LR	1
Lynch, KG	1
Hand, D	1
Tyndale, RF	1
Oncken, C	2
Schnoll, R	1
Anderson, KN	1
Lind, JN	1
Simeone, RM	1
Bobo, WV	1
Mitchell, AA	1
Riehle-Colarusso, T	1
Polen, KN	1
Reefhuis, J	2
Brajcich, MR	1
Palau, MA	1
Messer, RD	1
Murphy, ME	1
Marks, J	1
Fan, T	2
Lee, G	1
Hendrick, V	1
Suri, R	1
Gitlin, MJ	1
Ortiz-Portillo, E	1
Lusskin, SI	1
Khan, SJ	1
Ernst, C	1
Habib, S	1
Fersh, ME	1
Albertini, ES	1
Turner, E	1
Jones, M	1
Vaz, LR	1
Barboza, J	1
Trivedi, D	1
Freeman, MP	1
Hartmann-Boyce, J	1
Stead, LF	1
Cahill, K	1
Lancaster, T	1
Blitz, J	1
Fokina, VM	1
West, H	1
Clark, SM	1
Ahmed, MS	1
Hankins, GD	1
Nanovskaya, TN	1
Hebert, R	1
Rore, C	1
Brace, V	1
Danielian, P	1
Williams, D	1
Maritz, GS	1
Chisolm, MS	1
Brigham, EP	1
Tuten, M	1
Strain, EC	1
Jones, HE	1
Alwan, S	1
Rasmussen, SA	1
Friedman, JM	1
Myung, SK	1
Ju, W	1
Jung, HS	1
Park, CH	1
Oh, SW	1
Seo, H	1
Kim, H	1
Dell, DL	1
O'Brien, BW	1
Benowitz, N	1
Dempsey, D	1
Chan, B	1
Einarson, A	1
Koren, G	1
Okuyemi, KS	1
Ahluwalia, JS	1
Harris, KJ	1