bupropion has been researched along with Cardiac Toxicity in 6 studies
Bupropion: A propiophenone-derived antidepressant and antismoking agent that inhibits the uptake of DOPAMINE.
bupropion : An aromatic ketone that is propiophenone carrying a tert-butylamino group at position 2 and a chloro substituent at position 3 on the phenyl ring.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In 2011, the US Food and Drug Administration requested that GlaxoSmithKline perform retrospective adjudication of cardiovascular (CV) events reported in the bupropion drug-development trials for smoking cessation." | 7.85 | Cardiovascular adverse events in the drug-development program of bupropion for smoking cessation: A systematic retrospective adjudication effort. ( Ascher, J; Hasselblad, V; Huang, M; Kittle, J; Kolls, BJ; Krishen, A; Lopes, RD; Mahaffey, KW; Marquess, ML; McGuire, DK; Roe, MT; Russell, SD; Wilson, MD, 2017) |
| "Bupropion is an atypical antidepressant often used in the treatment of depression, tobacco cessation, seasonal affective disorder, and off label for ADHD." | 5.72 | Treatment of status epilepticus and prolonged QT after massive intentional bupropion overdose with lidocaine. ( Robinson, S, 2022) |
| "Bupropion cardiotoxicity widens QRS complexes by inhibiting cardiac gap junctions." | 4.31 | Sodium bicarbonate treatment for QRS widening in bupropion overdoses. ( Goldfine, C; Johnson, L; Simpson, M, 2023) |
| "Of the 266 recorded single bupropion overdoses, the most common symptoms were seizures (47." | 3.96 | Single-Agent Bupropion Exposures: Clinical Characteristics and an Atypical Cause of Serotonin Toxicity. ( Alsukaiti, WS; Calello, DP; Carpenter, J; Dunkley, C; Kazzi, Z; Kiernan, EA; Moran, TP; Murray, B; Rianprakaisang, T, 2020) |
| "In 2011, the US Food and Drug Administration requested that GlaxoSmithKline perform retrospective adjudication of cardiovascular (CV) events reported in the bupropion drug-development trials for smoking cessation." | 3.85 | Cardiovascular adverse events in the drug-development program of bupropion for smoking cessation: A systematic retrospective adjudication effort. ( Ascher, J; Hasselblad, V; Huang, M; Kittle, J; Kolls, BJ; Krishen, A; Lopes, RD; Mahaffey, KW; Marquess, ML; McGuire, DK; Roe, MT; Russell, SD; Wilson, MD, 2017) |
| "Bupropion is an atypical antidepressant often used in the treatment of depression, tobacco cessation, seasonal affective disorder, and off label for ADHD." | 1.72 | Treatment of status epilepticus and prolonged QT after massive intentional bupropion overdose with lidocaine. ( Robinson, S, 2022) |
| "Bupropion is a unique class of antidepressant." | 1.56 | Pediatric Bupropion Ingestions in Adolescents vs. Younger Children-a Tale of Two Populations. ( Gosen, J; Levine, M; Offerman, S; Thomas, SH, 2020) |
| " In the presence of a clinical history of long-term intake of anorexiants of this category, it is most important at autopsy to recognize and correctly interpret the acute and chronic myocardial lesions of the type herein described because they represent an anatomical substrate for arrhythmic death." | 1.46 | Cardiac pathologic findings in 3 unusual cases of sudden cardiac death related to anorexiant drugs. ( Agostini, V; Aromatario, M; Cerbelli, B; Ciallella, C; d'Amati, G; di Gioia, CRT; Foà, A; Leone, O; Lucena, J, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (33.33) | 24.3611 |
| 2020's | 4 (66.67) | 2.80 |
| Authors | Studies |
|---|---|
| Robinson, S | 1 |
| Simpson, M | 1 |
| Johnson, L | 1 |
| Goldfine, C | 1 |
| Offerman, S | 1 |
| Levine, M | 1 |
| Gosen, J | 1 |
| Thomas, SH | 1 |
| Murray, B | 1 |
| Carpenter, J | 1 |
| Dunkley, C | 1 |
| Moran, TP | 1 |
| Kiernan, EA | 1 |
| Rianprakaisang, T | 1 |
| Alsukaiti, WS | 1 |
| Calello, DP | 1 |
| Kazzi, Z | 1 |
| Kittle, J | 1 |
| Lopes, RD | 1 |
| Huang, M | 1 |
| Marquess, ML | 1 |
| Wilson, MD | 1 |
| Ascher, J | 1 |
| Krishen, A | 1 |
| Hasselblad, V | 1 |
| Kolls, BJ | 1 |
| Roe, MT | 1 |
| McGuire, DK | 1 |
| Russell, SD | 1 |
| Mahaffey, KW | 1 |
| Leone, O | 1 |
| Agostini, V | 1 |
| Foà, A | 1 |
| Cerbelli, B | 1 |
| di Gioia, CRT | 1 |
| Aromatario, M | 1 |
| Ciallella, C | 1 |
| Lucena, J | 1 |
| d'Amati, G | 1 |
6 other studies available for bupropion and Cardiac Toxicity
| Article | Year |
|---|---|
Treatment of status epilepticus and prolonged QT after massive intentional bupropion overdose with lidocaine.
Topics: Adolescent; Antidepressive Agents, Second-Generation; Bupropion; Cardiotoxicity; Drug Overdose; Fema | 2022 |
Sodium bicarbonate treatment for QRS widening in bupropion overdoses.
Topics: Adult; Bicarbonates; Bupropion; Cardiotoxicity; Drug Overdose; Electrocardiography; Female; Humans; | 2023 |
Pediatric Bupropion Ingestions in Adolescents vs. Younger Children-a Tale of Two Populations.
Topics: Adolescent; Age Factors; Antidepressive Agents, Second-Generation; Bupropion; Cardiotoxicity; Child; | 2020 |
Single-Agent Bupropion Exposures: Clinical Characteristics and an Atypical Cause of Serotonin Toxicity.
Topics: Adolescent; Adult; Antidepressive Agents, Second-Generation; Bupropion; Cardiotoxicity; Dyskinesia, | 2020 |
Cardiovascular adverse events in the drug-development program of bupropion for smoking cessation: A systematic retrospective adjudication effort.
Topics: Adult; Bupropion; Cardiotoxicity; Cardiovascular Diseases; Drug Discovery; Female; Humans; Male; Mid | 2017 |
Cardiac pathologic findings in 3 unusual cases of sudden cardiac death related to anorexiant drugs.
Topics: Adult; Appetite Stimulants; Autopsy; Bupropion; Cardiotoxicity; Death, Sudden, Cardiac; Fatal Outcom | 2017 |