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bupropion and Alcoholism

bupropion has been researched along with Alcoholism in 19 studies

Bupropion: A propiophenone-derived antidepressant and antismoking agent that inhibits the uptake of DOPAMINE.
bupropion : An aromatic ketone that is propiophenone carrying a tert-butylamino group at position 2 and a chloro substituent at position 3 on the phenyl ring.

Alcoholism: A primary, chronic disease with genetic, psychosocial, and environmental factors influencing its development and manifestations. The disease is often progressive and fatal. It is characterized by impaired control over drinking, preoccupation with the drug alcohol, use of alcohol despite adverse consequences, and distortions in thinking, most notably denial. Each of these symptoms may be continuous or periodic. (Morse & Flavin for the Joint Commission of the National Council on Alcoholism and Drug Dependence and the American Society of Addiction Medicine to Study the Definition and Criteria for the Diagnosis of Alcoholism: in JAMA 1992;268:1012-4)

Research Excerpts

ExcerptRelevanceReference
"This is a double-blind placebo-controlled study of sustained-release bupropion as a smoking cessation aid in alcoholics undergoing treatment for their alcoholism."9.12Bupropion and nicotine patch as smoking cessation aids in alcoholics. ( Agrawal, S; Grant, KM; Kelley, SS; Meyer, JR; Romberger, DJ; Smith, LM, 2007)
"To evaluate the efficacy of bupropion for smoking cessation in smokers with a former history of major depression or alcoholism, and changes in depressive symptoms during smoking abstinence."9.09Efficacy of bupropion for smoking cessation in smokers with a former history of major depression or alcoholism. ( Croghan, IT; Glover, ED; Hayford, KE; Hurt, RD; Offord, KP; Patten, CA; Rummans, TA; Sachs, DP; Schroeder, DR, 1999)
"Smoking cessation trials of sustained-release bupropion (bupropion SR) were initially conducted in a general population of smokers who were motivated to quit smoking."8.81Use of sustained-release bupropion in specific patient populations for smoking cessation. ( Tonstad, S, 2002)
"This is a double-blind placebo-controlled study of sustained-release bupropion as a smoking cessation aid in alcoholics undergoing treatment for their alcoholism."5.12Bupropion and nicotine patch as smoking cessation aids in alcoholics. ( Agrawal, S; Grant, KM; Kelley, SS; Meyer, JR; Romberger, DJ; Smith, LM, 2007)
"To evaluate the efficacy of bupropion for smoking cessation in smokers with a former history of major depression or alcoholism, and changes in depressive symptoms during smoking abstinence."5.09Efficacy of bupropion for smoking cessation in smokers with a former history of major depression or alcoholism. ( Croghan, IT; Glover, ED; Hayford, KE; Hurt, RD; Offord, KP; Patten, CA; Rummans, TA; Sachs, DP; Schroeder, DR, 1999)
" In the United States there are medications available to treat tobacco use disorders (nicotine replacement, bupropion, and varenicline), alcohol use disorders (naltrexone and acamprosate), and opioid use disorders (methadone and buprenorphine)."4.93Pharmacotherapy for Substance Use Disorders. ( Klein, JW, 2016)
"Alcoholism and nicotine dependence share many neurobiological underpinnings; the presence of one drug can cause a person to crave the other."4.83Treating smoking dependence in depressed alcoholics. ( Ait-Daoud, N; Breland, AB; Johnson, BA; Lynch, WJ; Marzani-Nissen, GR; Penberthy, JK, 2006)
" Although alcoholism has received the most attention, nicotine, heroin, and cocaine have all been shown to be influenced by heredity."4.82Anticraving medications for relapse prevention: a possible new class of psychoactive medications. ( O'Brien, CP, 2005)
"Smoking cessation trials of sustained-release bupropion (bupropion SR) were initially conducted in a general population of smokers who were motivated to quit smoking."4.81Use of sustained-release bupropion in specific patient populations for smoking cessation. ( Tonstad, S, 2002)
"Treatment with bupropion SR among abstinent alcoholic smokers did not delay relapse or result in improved long-term smoking abstinence."2.74A randomized, controlled trial of bupropion sustained-release for preventing tobacco relapse in recovering alcoholics. ( Croghan, IT; Decker, PA; Hays, JT; Hurt, RD; Offord, KP; Patten, CA, 2009)
"Guidance on Major Depressive Disorder (MDD) treatment in those with comorbid Alcohol Use Disorder (AUD) is limited."1.91Treatment outcomes in major depressive disorder in patients with comorbid alcohol use disorder: A STAR*D analysis. ( Blumberger, DM; Daskalakis, ZJ; Jones, BDM; Le Foll, B; Sloan, ME; Tang, VM; Voineskos, D; Wang, G; Weissman, CR; Yu, D, 2023)
"fluoxetine treatment induced a long-lasting increase in alcohol consumption during relapse, an effect that was not observed in the case of bupropion treatment."1.51Bupropion, a possible antidepressant without negative effects on alcohol relapse. ( Alen, F; Antón, M; Arco, R; Ballesta, A; de Fonseca, FR; de Heras, RG; Nogueira-Arjona, R; Orio, L; Pavón, FJ; Ramírez-López, M; Romero-Sanchiz, P; Serrano, A; Suárez, J; Vargas, A, 2019)

Research

Studies (19)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (15.79)18.2507
2000's8 (42.11)29.6817
2010's4 (21.05)24.3611
2020's4 (21.05)2.80

Authors

AuthorsStudies
Tang, VM1
Yu, D1
Weissman, CR1
Jones, BDM1
Wang, G1
Sloan, ME1
Blumberger, DM1
Daskalakis, ZJ1
Le Foll, B1
Voineskos, D1
Deng, X1
Shang, X1
Guo, K1
Zhou, L1
Wang, Y1
Wu, Y1
Liang, S1
E, F1
Liu, W1
Wang, Z1
Li, X1
Yang, K1
Rábade-Castedo, C1
de Granda-Orive, JI1
Riesco-Miranda, JA1
De Higes-Martínez, E1
Ramos-Pinedo, Á1
Cabrera-César, E1
Signes-Costa Miñana, J1
García Rueda, M1
Pastor-Esplá, E1
Jiménez-Ruiz, CA1
Swinford-Jackson, SE1
O'Brien, CP2
Kenny, PJ1
Vanderschuren, LJMJ1
Unterwald, EM1
Pierce, RC1
Ballesta, A1
Orio, L1
Arco, R1
Vargas, A1
Romero-Sanchiz, P1
Nogueira-Arjona, R1
de Heras, RG1
Antón, M1
Ramírez-López, M1
Serrano, A1
Pavón, FJ1
de Fonseca, FR1
Suárez, J1
Alen, F1
Klein, JW1
Hays, JT1
Hurt, RD2
Decker, PA1
Croghan, IT2
Offord, KP2
Patten, CA2
Saracino, MA1
Marcheselli, C1
Somaini, L1
Gerra, G1
De Stefano, F1
Pieri, MC1
Raggi, MA1
Karam-Hage, M1
Strobbe, S1
Robinson, JD1
Brower, KJ1
Tonstad, S1
Bagley, SC1
Yaeger, D1
Doran, CM1
Duszynski, KM1
Beilby, JJ1
Mattick, RP1
Ait-Daoud, N1
Lynch, WJ1
Penberthy, JK1
Breland, AB1
Marzani-Nissen, GR1
Johnson, BA1
Grant, KM1
Kelley, SS1
Smith, LM1
Agrawal, S1
Meyer, JR1
Romberger, DJ1
Nunes, EV1
McGrath, PJ1
Quitkin, FM1
Litten, RZ1
Allen, JP1
Hayford, KE1
Rummans, TA1
Schroeder, DR1
Glover, ED1
Sachs, DP1
Sullivan, MA1
Covey, LS1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Pharmacologic Relapse Prevention for Alcoholic Smokers[NCT00000457]Phase 2195 participants (Actual)Interventional1998-06-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

9 reviews available for bupropion and Alcoholism

ArticleYear
Efficacy and safety of antidepressants for smoking cessation: A systematic review and network meta-analysis.
    Addiction biology, 2023, Volume: 28, Issue:8

    Topics: Alcoholism; Antidepressive Agents; Bupropion; Humans; Network Meta-Analysis; Nortriptyline; Smoking;

2023
Clinical Practice Guideline of Spanish Society of Pneumology and Thoracic Surgery (SEPAR) on Pharmacological Treatment of Tobacco Dependence 2023.
    Archivos de bronconeumologia, 2023, Volume: 59, Issue:10

    Topics: Adolescent; Alcoholism; Bupropion; Female; Humans; Nicotinic Agonists; Pregnancy; Pulmonary Medicine

2023
Pharmacotherapy for Substance Use Disorders.
    The Medical clinics of North America, 2016, Volume: 100, Issue:4

    Topics: Age Factors; Alcohol Deterrents; Alcoholism; Antidepressive Agents; Buprenorphine; Bupropion; Drug T

2016
Use of sustained-release bupropion in specific patient populations for smoking cessation.
    Drugs, 2002, Volume: 62 Suppl 2

    Topics: Alcoholism; Body Weight; Bupropion; Delayed-Action Preparations; Depression; Dopamine Uptake Inhibit

2002
Anticraving medications for relapse prevention: a possible new class of psychoactive medications.
    The American journal of psychiatry, 2005, Volume: 162, Issue:8

    Topics: Alcoholism; Behavior, Addictive; Bupropion; Cocaine-Related Disorders; Disulfiram; Humans; Naltrexon

2005
Treating smoking dependence in depressed alcoholics.
    Alcohol research & health : the journal of the National Institute on Alcohol Abuse and Alcoholism, 2006, Volume: 29, Issue:3

    Topics: Alcoholism; Antidepressive Agents; Bupropion; Clinical Trials as Topic; Cognitive Behavioral Therapy

2006
Treating anxiety in patients with alcoholism.
    The Journal of clinical psychiatry, 1995, Volume: 56 Suppl 2

    Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Alcoholism; Antidepressive Agents; Anxiety Disorders

1995
Medications for alcohol, illicit drug, and tobacco dependence. An update of research findings.
    Journal of substance abuse treatment, 1999, Volume: 16, Issue:2

    Topics: Acamprosate; Alcohol Deterrents; Alcoholism; Buprenorphine; Bupropion; Forecasting; Humans; Methadyl

1999
Nicotine dependence: the role for antidepressants and anxiolytics.
    Current opinion in investigational drugs (London, England : 2000), 2002, Volume: 3, Issue:2

    Topics: Alcoholism; Anti-Anxiety Agents; Antidepressive Agents; Anxiety Disorders; Attention Deficit Disorde

2002

Trials

5 trials available for bupropion and Alcoholism

ArticleYear
A randomized, controlled trial of bupropion sustained-release for preventing tobacco relapse in recovering alcoholics.
    Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2009, Volume: 11, Issue:7

    Topics: Adult; Aged; Alcoholism; Bupropion; Delayed-Action Preparations; Dopamine Uptake Inhibitors; Double-

2009
Bupropion-SR for smoking cessation in early recovery from alcohol dependence: a placebo-controlled, double-blind pilot study.
    The American journal of drug and alcohol abuse, 2011, Volume: 37, Issue:6

    Topics: Alcoholism; Bupropion; Delayed-Action Preparations; Dopamine Uptake Inhibitors; Double-Blind Method;

2011
Hyponatremia associated with bupropion, a case verified by rechallenge.
    Journal of clinical psychopharmacology, 2005, Volume: 25, Issue:1

    Topics: Alcoholism; Antidepressive Agents, Second-Generation; Bipolar Disorder; Bupropion; Cocaine-Related D

2005
Bupropion and nicotine patch as smoking cessation aids in alcoholics.
    Alcohol (Fayetteville, N.Y.), 2007, Volume: 41, Issue:5

    Topics: Administration, Cutaneous; Adult; Alcoholism; Bupropion; Community Health Services; Delayed-Action P

2007
Efficacy of bupropion for smoking cessation in smokers with a former history of major depression or alcoholism.
    The British journal of psychiatry : the journal of mental science, 1999, Volume: 174

    Topics: Adult; Alcoholism; Antidepressive Agents, Second-Generation; Bupropion; Delayed-Action Preparations;

1999

Other Studies

5 other studies available for bupropion and Alcoholism

ArticleYear
Treatment outcomes in major depressive disorder in patients with comorbid alcohol use disorder: A STAR*D analysis.
    Journal of affective disorders, 2023, 10-15, Volume: 339

    Topics: Alcoholism; Antidepressive Agents; Bupropion; Comorbidity; Depressive Disorder, Major; Humans; Treat

2023
The Persistent Challenge of Developing Addiction Pharmacotherapies.
    Cold Spring Harbor perspectives in medicine, 2021, 11-01, Volume: 11, Issue:11

    Topics: Acamprosate; Alcohol Deterrents; Alcoholism; Bupropion; Central Nervous System Stimulants; Cocaine-R

2021
Bupropion, a possible antidepressant without negative effects on alcohol relapse.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2019, Volume: 29, Issue:6

    Topics: Alcohol Drinking; Alcoholism; Animals; Antidepressive Agents, Second-Generation; Bupropion; Dopamine

2019
Simultaneous determination of disulfiram and bupropion in human plasma of alcohol and nicotine abusers.
    Analytical and bioanalytical chemistry, 2010, Volume: 398, Issue:5

    Topics: Alcoholism; Bupropion; Chromatography, High Pressure Liquid; Disulfiram; Humans; Molecular Structure

2010
Use of pharmacotherapies for the management of addictive behaviours in Australian clinical practice.
    Addictive behaviors, 2006, Volume: 31, Issue:11

    Topics: Acamprosate; Alcohol Deterrents; Alcoholism; Australia; Bupropion; Dopamine Uptake Inhibitors; Femal

2006