Page last updated: 2024-10-17

bupropion and Aging

bupropion has been researched along with Aging in 13 studies

Bupropion: A propiophenone-derived antidepressant and antismoking agent that inhibits the uptake of DOPAMINE.
bupropion : An aromatic ketone that is propiophenone carrying a tert-butylamino group at position 2 and a chloro substituent at position 3 on the phenyl ring.

Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

Research Excerpts

ExcerptRelevanceReference
"The aim of this study was to assess the effects of the antidepressant bupropion on anxiety and novelty-seeking in adolescent mice of different ages and adults."7.79Bupropion induced changes in exploratory and anxiety-like behaviour in NMRI male mice depends on the age. ( Carrasco, MC; Redolat, R; Vidal, J, 2013)
"Insulin resistance was also assessed at the end."6.71Weight gain and cardiovascular risk factors during smoking cessation with bupropion or nicotine. ( Alvarez, F; Botella-Carretero, JI; Cantarero, M; Escobar-Morreale, HF; García, G; Martín, I; Valero, AM; Varela, C, 2004)
" BAG was also not associated with a change in depression severity over time across both arms in the blinded phase or in the subsequent open-label bupropion phase."5.51Structural MRI-Based Measures of Accelerated Brain Aging do not Moderate the Acute Antidepressant Response in Late-Life Depression. ( Ahmed, R; Bermudez, C; Boyd, BD; Christman, S; Elson, D; Kang, H; Landman, BA; Ryan, C; Szymkowicz, SM; Taylor, WD, 2022)
"Bupropion and smoking cessation counseling are underutilized even when provided within the context of a randomized trial."5.17Factors associated with discontinuation of bupropion and counseling among African American light smokers in a randomized clinical trial. ( Ahluwalia, JS; Benowitz, NL; Buchanan, TS; Cox, LS; Faseru, B; Mayo, MS; Nollen, NL; Tyndale, RF, 2013)
"The aim of this study was to assess the effects of the antidepressant bupropion on anxiety and novelty-seeking in adolescent mice of different ages and adults."3.79Bupropion induced changes in exploratory and anxiety-like behaviour in NMRI male mice depends on the age. ( Carrasco, MC; Redolat, R; Vidal, J, 2013)
"Insulin resistance was also assessed at the end."2.71Weight gain and cardiovascular risk factors during smoking cessation with bupropion or nicotine. ( Alvarez, F; Botella-Carretero, JI; Cantarero, M; Escobar-Morreale, HF; García, G; Martín, I; Valero, AM; Varela, C, 2004)
" Understanding the pharmacokinetic (PK) properties and formulations of bupropion can help optimize clinical use."2.43Bupropion for major depressive disorder: Pharmacokinetic and formulation considerations. ( Jefferson, JW; Muir, KT; Pradko, JF, 2005)

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19901 (7.69)18.7374
1990's1 (7.69)18.2507
2000's6 (46.15)29.6817
2010's4 (30.77)24.3611
2020's1 (7.69)2.80

Authors

AuthorsStudies
Ahmed, R1
Ryan, C1
Christman, S1
Elson, D1
Bermudez, C1
Landman, BA1
Szymkowicz, SM1
Boyd, BD1
Kang, H1
Taylor, WD1
Carrasco, MC2
Vidal, J2
Redolat, R3
Nollen, NL1
Mayo, MS1
Ahluwalia, JS1
Tyndale, RF1
Benowitz, NL1
Faseru, B1
Buchanan, TS1
Cox, LS1
Pearce, RE1
Gaedigk, R1
Twist, GP1
Dai, H1
Riffel, AK1
Leeder, JS1
Gaedigk, A1
Gómez, C1
Carrasco, C1
Iñiguez, SD1
Warren, BL1
Parise, EM1
Alcantara, LF1
Schuh, B1
Maffeo, ML1
Manojlovic, Z1
Bolaños-Guzmán, CA1
Spencer, TJ1
Botella-Carretero, JI1
Escobar-Morreale, HF1
Martín, I1
Valero, AM1
Alvarez, F1
García, G1
Varela, C1
Cantarero, M1
Gómez, MC1
Jefferson, JW1
Pradko, JF1
Muir, KT1
Su, SW1
Cherng, CF1
Lin, YC1
Yu, L1
Gazzara, RA1
Andersen, SL1
Marshall, JF1
Altar, CA1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Enhancing Tobacco Use Treatment for African American Light Smokers[NCT00666978]Phase 4540 participants (Actual)Interventional2007-12-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Number of Participants With Salivary Cotinine-verified Smoking Abstinence at 6 Months

Salivary cotinine-verified smoking abstinence at 6 months. A cut point of 15 ng/ml was used to differentiate smokers from nonsmokers. (NCT00666978)
Timeframe: 6 months

InterventionParticipants (Count of Participants)
Bupropion Arm36
Placebo Arm27

Number of Participants for Each CYP2B6 Allele

We genotyped CYP2B6 in 268 from the Bupropion arm as this polymorphism is related to bupropion metabolism. (NCT00666978)
Timeframe: Week 3

InterventionParticipants (Count of Participants)
CYP2B6*4 Allele FrequencyCYP2B6*5 Allele FrequencyCYP2B6*6 Allele FrequencyCYP2B6*9 Allele FrequencyCYP2B6*16 Allele FrequencyCYP2B6*18 Allele FrequencyCYP2B6*22 Allele Frequency
Bupropion Arm269500176

Number of Slow and Fast Metabolizers by Genotype

"Analyzed CYP2A6 by genotype. The variants present in people in the slow genotype group include *17, *20, *23,*27, *35, *9, *2, *25, *26, and *4. The fast metabolizers have none of the variant alleles tested.~Slow metabolizers have any reduction or loss of function variant. Fast metabolizers are *1/*1 genotype by exclusion." (NCT00666978)
Timeframe: Week 0

InterventionParticipants (Count of Participants)
Slow Metabolizers by GenotypeFast Metabolizers by Genotype
All Study Participants265269

Number of Slow and Fast Metabolizers by Metabolite Ratio

"Analyzed CYP2A6 by activity, called the nicotine metabolite ratio using a split between slow and fast metabolism at 0.31.~The variants present in people in the slow genotype group include *17, *20, *23,*27, *35, *9, *2, *25, *26, and *4. The fast metabolizers have none of the variant alleles tested.~Blood samples were collected for 3HC/COT ratio at Week 0." (NCT00666978)
Timeframe: Weeks 0

InterventionParticipants (Count of Participants)
Fast Metabolizers by Nicotine Metabolite RatioSlow Metabolizers by Nicotine Metabolite Ratio
All Study Participants236214

Reviews

2 reviews available for bupropion and Aging

ArticleYear
ADHD treatment across the life cycle.
    The Journal of clinical psychiatry, 2004, Volume: 65 Suppl 3

    Topics: Adolescent; Adult; Aging; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic

2004
Bupropion for major depressive disorder: Pharmacokinetic and formulation considerations.
    Clinical therapeutics, 2005, Volume: 27, Issue:11

    Topics: Aging; Animals; Antidepressive Agents, Second-Generation; Area Under Curve; Aryl Hydrocarbon Hydroxy

2005

Trials

3 trials available for bupropion and Aging

ArticleYear
Structural MRI-Based Measures of Accelerated Brain Aging do not Moderate the Acute Antidepressant Response in Late-Life Depression.
    The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2022, Volume: 30, Issue:9

    Topics: Aging; Antidepressive Agents; Brain; Bupropion; Depression; Humans; Magnetic Resonance Imaging

2022
Factors associated with discontinuation of bupropion and counseling among African American light smokers in a randomized clinical trial.
    Annals of behavioral medicine : a publication of the Society of Behavioral Medicine, 2013, Volume: 46, Issue:3

    Topics: Aging; Black or African American; Bupropion; Counseling; Delayed-Action Preparations; Female; Humans

2013
Weight gain and cardiovascular risk factors during smoking cessation with bupropion or nicotine.
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 2004, Volume: 36, Issue:3

    Topics: Administration, Cutaneous; Adult; Aging; Blood Pressure; Bupropion; Cardiovascular Diseases; Diastol

2004

Other Studies

8 other studies available for bupropion and Aging

ArticleYear
Bupropion induced changes in exploratory and anxiety-like behaviour in NMRI male mice depends on the age.
    Behavioural processes, 2013, Volume: 98

    Topics: Aging; Animals; Antidepressive Agents, Second-Generation; Anxiety; Bupropion; Dose-Response Relation

2013
Developmental Expression of CYP2B6: A Comprehensive Analysis of mRNA Expression, Protein Content and Bupropion Hydroxylase Activity and the Impact of Genetic Variation.
    Drug metabolism and disposition: the biological fate of chemicals, 2016, Volume: 44, Issue:7

    Topics: Adolescent; Adult; Age Factors; Aged; Aging; Biotransformation; Bupropion; Child; Child, Preschool;

2016
Adolescent and adult mice display differential sensitivity to the effects of bupropion on the acquisition of a water maze task.
    Pharmacological reports : PR, 2017, Volume: 69, Issue:1

    Topics: Age Factors; Aging; Animals; Antidepressive Agents, Second-Generation; Bupropion; Dose-Response Rela

2017
Nicotine exposure during adolescence induces a depression-like state in adulthood.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2009, Volume: 34, Issue:6

    Topics: Aging; Animals; Antidepressive Agents, Second-Generation; Anxiety; Bupropion; Cholinergic Agents; De

2009
Effects of acute bupropion administration on locomotor activity in adolescent and adult mice.
    Behavioural pharmacology, 2005, Volume: 16, Issue:1

    Topics: Aging; Animals; Bupropion; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Male; Mice;

2005
Prenatal exposure of bupropion may enhance agitation, anxiety responses, and sensitivity to cocaine effects in adult mice.
    The Chinese journal of physiology, 2007, Feb-28, Volume: 50, Issue:1

    Topics: Aging; Animals; Antidepressive Agents, Second-Generation; Anxiety; Bupropion; Cocaine; Dose-Response

2007
The effects of bupropion in vivo in the neostriatum of 5-day-old and adult rats.
    Brain research. Developmental brain research, 1997, May-20, Volume: 100, Issue:1

    Topics: Aging; Animals; Animals, Newborn; Bupropion; Dopamine; Dopamine Uptake Inhibitors; Dose-Response Rel

1997
Striatal dopamine uptake and swim performance of the aged rat.
    Brain research, 1986, Jul-30, Volume: 379, Issue:1

    Topics: Aging; Animals; Bupropion; Corpus Striatum; Desipramine; Dopamine; Dopamine Antagonists; Male; Motor

1986