buprenorphine and Arthritis--Rheumatoid

Buprenorphine is recommended for use as an analgesic in animal models including in murine models of collagen-induced arthritis (CIA). However, the effect of buprenorphine on the expression of disease-associated biomarkers is not well defined. We examined the effect of buprenorphine administration on disease progression and the expression of inflammatory and oxidative stress markers, in a murine model of CIA. Buprenorphine administration altered the expression of cytokines, IFN-

Topics: Adult; Aged; Analgesics, Opioid; Animals; Antioxidants; Arthritis, Experimental; Arthritis, Rheumatoid; Biomarkers; Buprenorphine; Catalase; Cohort Studies; Collagen; Cytokines; Disease Models, Animal; Disease Progression; Female; Humans; Inflammation; Male; Matrix Metalloproteinase 3; Mice; Mice, Inbred DBA; Middle Aged; Nitric Oxide Synthase Type II; Oxidative Stress; Real-Time Polymerase Chain Reaction; Superoxide Dismutase-1