buprenorphine--naloxone-drug-combination and Burns

Buprenorphine is commonly used to manage opioid use disorder; however, the literature describes its potential role in treating treatment-resistant depression.. We present a patient with bipolar disorder and opioid use disorder, who presented status post-suicide attempt.. After initiating buprenorphine-naloxone, the patient reported rapid improvement in depressive symptoms, pain, and suicidal ideation.. This case demonstrates buprenorphine's antisuicidal and mood-stabilizing capabilities, potentially via antagonizing κ-opioid receptors as well as reinstating the balance between reward and antireward circuitry.. This case highlights buprenorphine-naloxone as a treatment for both treatment-resistant depression and opioid use disorder, as well as buprenorphine's rapid antidepressant, analgesic, and antisuicidal effects. (Am J Addict 2021;30:80-82).

Topics: Adult; Analgesics, Opioid; Bipolar Disorder; Buprenorphine, Naloxone Drug Combination; Burns; Depression; Humans; Male; Opioid-Related Disorders; Pain; Receptors, Opioid, kappa; Suicidal Ideation; Suicide, Attempted