bupivacaine has been researched along with Ventricular Fibrillation in 20 studies
Bupivacaine: A widely used local anesthetic agent.
1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide : A piperidinecarboxamide obtained by formal condensation of the carboxy group of N-butylpipecolic acid with the amino group of 2,6-dimethylaniline.
bupivacaine : A racemate composed of equimolar amounts of dextrobupivacaine and levobupivacaine. Used (in the form of its hydrochloride hydrate) as a local anaesthetic.
Ventricular Fibrillation: A potentially lethal cardiac arrhythmia that is characterized by uncoordinated extremely rapid firing of electrical impulses (400-600/min) in HEART VENTRICLES. Such asynchronous ventricular quivering or fibrillation prevents any effective cardiac output and results in unconsciousness (SYNCOPE). It is one of the major electrocardiographic patterns seen with CARDIAC ARREST.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We report a case of bupivacaine-induced Brugada syndrome, in which we investigated the genetic, biophysical and path physiological mechanism involved." | 7.73 | Genetic and biophysical basis for bupivacaine-induced ST segment elevation and VT/VF. Anesthesia unmasked Brugada syndrome. ( Antzelevitch, C; Brugada, R; Burashnikov, E; Crijns, HJ; Delhaas, T; Dumaine, R; Hong, K; Oliva, A; Rodriguez, LM; Sicouri, S; Timmermans, C; Vernooy, K, 2006) |
| "In this animal study pretreatment with bupivacaine attenuated the progression of myocardial acidosis during ventricular fibrillation." | 7.72 | The effect of bupivacaine on myocardial tissue hypoxia and acidosis during ventricular fibrillation. ( Feinstein, D; Hoffman, W; Paisanthasan, C; Weinberg, G, 2004) |
| "Ventricular fibrillation (VF) is a cause of death in bupivacaine-induced cardiovascular toxicity." | 7.70 | Lidocaine increases the ventricular fibrillation threshold during bupivacaine-induced cardiotoxicity in pigs. ( Endoh, S; Fujita, Y; Sari, A; Yasukawa, T, 1998) |
| "Myocardial ischemia sensitizes the cardiotoxic effects of bupivacaine, especially the propensity to ventricular fibrillation." | 7.69 | Bupivacaine hastens the ischemia-induced decrease of the electrical ventricular fibrillation threshold. ( Aupetit, JF; Bertrix, L; Faucon, G; Freysz, M; Loufoua, J; Timour, Q, 1995) |
| "A postoperative cardiac surgical patient developed ventricular fibrillation immediately after accidental pericardial injection of bupivacaine at room temperature." | 7.68 | Ventricular fibrillation after accidental injection of bupivacaine into the pericardium. ( De Hert, SG; De Jongh, RF; Even, BJ, 1992) |
| "Bupivacaine is a commonly used local anesthetic in dental, ophthalmologic, and simple surgical procedures." | 5.30 | Bupivacaine-induced seizures and ventricular fibrillation in a 13-year-old girl undergoing wound debridement. ( Newman, RD; Yan, AC, 1998) |
| " In this case report, we describe an 80-year-old patient with ischemic cardiomyopathy and multiple implantable cardioverter-defibrillator shocks due to refractory ventricular tachycardia and ventricular fibrillation who was unable to continue biweekly stellate ganglion block procedures using bupivacaine 0." | 3.83 | Comparative efficacy of stellate ganglion block with bupivacaine vs pulsed radiofrequency in a patient with refractory ventricular arrhythmias. ( Ahadian, F; Hayase, J; Krummen, DE; Narayan, SM; Vampola, S, 2016) |
| "We report a case of bupivacaine-induced Brugada syndrome, in which we investigated the genetic, biophysical and path physiological mechanism involved." | 3.73 | Genetic and biophysical basis for bupivacaine-induced ST segment elevation and VT/VF. Anesthesia unmasked Brugada syndrome. ( Antzelevitch, C; Brugada, R; Burashnikov, E; Crijns, HJ; Delhaas, T; Dumaine, R; Hong, K; Oliva, A; Rodriguez, LM; Sicouri, S; Timmermans, C; Vernooy, K, 2006) |
| "In this animal study pretreatment with bupivacaine attenuated the progression of myocardial acidosis during ventricular fibrillation." | 3.72 | The effect of bupivacaine on myocardial tissue hypoxia and acidosis during ventricular fibrillation. ( Feinstein, D; Hoffman, W; Paisanthasan, C; Weinberg, G, 2004) |
| "Myocardial ischemia sensitizes the cardiotoxic effects of bupivacaine, especially the propensity to ventricular fibrillation." | 3.69 | Bupivacaine hastens the ischemia-induced decrease of the electrical ventricular fibrillation threshold. ( Aupetit, JF; Bertrix, L; Faucon, G; Freysz, M; Loufoua, J; Timour, Q, 1995) |
| "The impairment of intraventricular conduction by bupivacaine may result in reentrant arrhythmias including ventricular fibrillation." | 3.68 | Enhancement by ischemia of the risk of cardiac disorders, especially fibrillation, in regional anesthesia with bupivacaine. ( Bertrix, L; Faucon, G; Freysz, M; Loufoua-Moundanga, J; Omar, S; Timour, Q, 1993) |
| "A postoperative cardiac surgical patient developed ventricular fibrillation immediately after accidental pericardial injection of bupivacaine at room temperature." | 3.68 | Ventricular fibrillation after accidental injection of bupivacaine into the pericardium. ( De Hert, SG; De Jongh, RF; Even, BJ, 1992) |
| "Bupivacaine was infused with a syringe driver via central venous catheter at a rate of 1 mg·kg(-1)·min(-1) until circulatory arrest." | 1.38 | Resuscitation strategies from bupivacaine-induced cardiac arrest. ( Bettschart-Wolfensberger, R; Jurado, OM; Mauch, J; Spielmann, N; Weiss, M, 2012) |
| "Doses were chosen to avoid convulsions (smaller dose 6." | 1.30 | Cardiovascular and central nervous system effects of intravenous levobupivacaine and bupivacaine in sheep. ( Huang, YF; Mather, LE; Pryor, ME; Veering, BT, 1998) |
| "Bupivacaine is a commonly used local anesthetic in dental, ophthalmologic, and simple surgical procedures." | 1.30 | Bupivacaine-induced seizures and ventricular fibrillation in a 13-year-old girl undergoing wound debridement. ( Newman, RD; Yan, AC, 1998) |
| "Bupivacaine infusion was continued until cardiovascular collapse." | 1.28 | Effect of epinephrine on central nervous system and cardiovascular system toxicity of bupivacaine in pigs. ( Bernards, CM; Brown, DL; Carpenter, RL; Kenter, ME; Rupp, SM; Thompson, GE, 1989) |
| "Ventricular fibrillation was preceded by progressive widening of the QRS complexes recorded over the area perfused by the LAD." | 1.27 | Differential depressant and electrophysiologic cardiotoxicity of local anesthetics: an experimental study with special reference to lidocaine and bupivacaine. ( Häggmark, S; Johansson, G; Nath, S; Reiz, S, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (10.00) | 18.7374 |
| 1990's | 7 (35.00) | 18.2507 |
| 2000's | 8 (40.00) | 29.6817 |
| 2010's | 3 (15.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Meng, L | 1 |
| Tseng, CH | 1 |
| Shivkumar, K | 2 |
| Ajijola, O | 1 |
| Hayase, J | 1 |
| Vampola, S | 1 |
| Ahadian, F | 1 |
| Narayan, SM | 1 |
| Krummen, DE | 1 |
| Sánchez Ortega, JL | 1 |
| González Pérez, P | 1 |
| Escribano Jiménez, M | 1 |
| Mauch, J | 1 |
| Jurado, OM | 1 |
| Spielmann, N | 1 |
| Bettschart-Wolfensberger, R | 1 |
| Weiss, M | 1 |
| Srinivasa, V | 1 |
| Gerner, P | 1 |
| Haderer, A | 1 |
| Abdi, S | 1 |
| Jarolim, P | 1 |
| Wang, GK | 1 |
| Weinberg, G | 1 |
| Paisanthasan, C | 1 |
| Feinstein, D | 1 |
| Hoffman, W | 1 |
| Coleman, LS | 1 |
| Mahajan, A | 1 |
| Moore, J | 1 |
| Cesario, DA | 1 |
| Issa, ZF | 1 |
| Zipes, DP | 1 |
| Vernooy, K | 1 |
| Sicouri, S | 1 |
| Dumaine, R | 1 |
| Hong, K | 1 |
| Oliva, A | 1 |
| Burashnikov, E | 1 |
| Timmermans, C | 1 |
| Delhaas, T | 1 |
| Crijns, HJ | 1 |
| Antzelevitch, C | 1 |
| Rodriguez, LM | 1 |
| Brugada, R | 1 |
| Freysz, M | 2 |
| Timour, Q | 2 |
| Bertrix, L | 2 |
| Loufoua, J | 1 |
| Aupetit, JF | 1 |
| Faucon, G | 2 |
| Loufoua-Moundanga, J | 1 |
| Omar, S | 1 |
| Huang, YF | 1 |
| Pryor, ME | 1 |
| Mather, LE | 1 |
| Veering, BT | 1 |
| Fujita, Y | 1 |
| Endoh, S | 1 |
| Yasukawa, T | 1 |
| Sari, A | 1 |
| Yan, AC | 1 |
| Newman, RD | 1 |
| Groban, L | 1 |
| Deal, DD | 1 |
| Vernon, JC | 1 |
| James, RL | 1 |
| Butterworth, J | 1 |
| Even, BJ | 1 |
| De Jongh, RF | 1 |
| De Hert, SG | 1 |
| de La Coussaye, JE | 1 |
| Brugada, J | 1 |
| Allessie, MA | 1 |
| Bernards, CM | 1 |
| Carpenter, RL | 1 |
| Kenter, ME | 1 |
| Brown, DL | 1 |
| Rupp, SM | 1 |
| Thompson, GE | 1 |
| Nath, S | 1 |
| Häggmark, S | 1 |
| Johansson, G | 1 |
| Reiz, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Endocardial-Epicardial Radiofrequency Ablation of Ventricular Tachycardia in Patients With Ischemic Cardiomyopathy[NCT04512911] | Early Phase 1 | 0 participants (Actual) | Interventional | 2023-01-31 | Withdrawn (stopped due to IRB approval expired 1/23/2023 and eclipsed the 6 month institutional window where study can be reinitiated via progress report. No enrollment has taken place.) | ||
| Pre-Operative Stellate Ganglion to Prevent Post-Operative Atrial Fibrillation[NCT05656170] | 0 participants (Actual) | Interventional | 2023-10-01 | Withdrawn (stopped due to Unable to begin study) | |||
| Can Stellar Ganglion Blockage be an Alternative Treatment for Refractory Ventricular Arrhythmias?[NCT05712122] | 10 participants (Actual) | Interventional | 2021-01-01 | Completed | |||
| Prophylactic Cardiac Sympathetic Denervation for Prevention of Ventricular Tachyarrhythmias (PREVENT VT)[NCT01013714] | Phase 3 | 40 participants (Anticipated) | Interventional | 2021-07-26 | Recruiting | ||
| Safety of Local Dental Anesthesia in Patients With Cardiac Channelopathies[NCT03182777] | 31 participants (Actual) | Interventional | 2015-05-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for bupivacaine and Ventricular Fibrillation
| Article | Year |
|---|---|
Efficacy of Stellate Ganglion Blockade in Managing Electrical Storm: A Systematic Review.
Topics: Adult; Aged; Anesthetics, Local; Autonomic Nerve Block; Bupivacaine; Female; Humans; Male; Middle Ag | 2017 |
Efficacy of Stellate Ganglion Blockade in Managing Electrical Storm: A Systematic Review.
Topics: Adult; Aged; Anesthetics, Local; Autonomic Nerve Block; Bupivacaine; Female; Humans; Male; Middle Ag | 2017 |
Efficacy of Stellate Ganglion Blockade in Managing Electrical Storm: A Systematic Review.
Topics: Adult; Aged; Anesthetics, Local; Autonomic Nerve Block; Bupivacaine; Female; Humans; Male; Middle Ag | 2017 |
Efficacy of Stellate Ganglion Blockade in Managing Electrical Storm: A Systematic Review.
Topics: Adult; Aged; Anesthetics, Local; Autonomic Nerve Block; Bupivacaine; Female; Humans; Male; Middle Ag | 2017 |
Efficacy of Stellate Ganglion Blockade in Managing Electrical Storm: A Systematic Review.
Topics: Adult; Aged; Anesthetics, Local; Autonomic Nerve Block; Bupivacaine; Female; Humans; Male; Middle Ag | 2017 |
Efficacy of Stellate Ganglion Blockade in Managing Electrical Storm: A Systematic Review.
Topics: Adult; Aged; Anesthetics, Local; Autonomic Nerve Block; Bupivacaine; Female; Humans; Male; Middle Ag | 2017 |
Efficacy of Stellate Ganglion Blockade in Managing Electrical Storm: A Systematic Review.
Topics: Adult; Aged; Anesthetics, Local; Autonomic Nerve Block; Bupivacaine; Female; Humans; Male; Middle Ag | 2017 |
Efficacy of Stellate Ganglion Blockade in Managing Electrical Storm: A Systematic Review.
Topics: Adult; Aged; Anesthetics, Local; Autonomic Nerve Block; Bupivacaine; Female; Humans; Male; Middle Ag | 2017 |
Efficacy of Stellate Ganglion Blockade in Managing Electrical Storm: A Systematic Review.
Topics: Adult; Aged; Anesthetics, Local; Autonomic Nerve Block; Bupivacaine; Female; Humans; Male; Middle Ag | 2017 |
[Brugada syndrome, bupivacaine, lidocaine, and techniques to provide local or regional anesthesia: comments on "Ventricular fibrillation in a patient with a type I Brugada syndrome ECG pattern and hypokalemia"].
Topics: Anesthesia, Conduction; Anesthetics, Local; Brugada Syndrome; Bupivacaine; Female; Humans; Hypokalem | 2008 |
18 other studies available for bupivacaine and Ventricular Fibrillation
| Article | Year |
|---|---|
Comparative efficacy of stellate ganglion block with bupivacaine vs pulsed radiofrequency in a patient with refractory ventricular arrhythmias.
Topics: Aged, 80 and over; Anesthetics, Local; Autonomic Nerve Block; Bupivacaine; Catheter Ablation; Humans | 2016 |
Resuscitation strategies from bupivacaine-induced cardiac arrest.
Topics: Anesthetics, Local; Animals; Blood Gas Analysis; Blood Pressure; Bupivacaine; Cardiopulmonary Resusc | 2012 |
The relative toxicity of amitriptyline, bupivacaine, and levobupivacaine administered as rapid infusions in rats.
Topics: Amitriptyline; Anesthetics, Local; Animals; Antidepressive Agents, Tricyclic; Blood Pressure; Bupiva | 2003 |
The effect of bupivacaine on myocardial tissue hypoxia and acidosis during ventricular fibrillation.
Topics: Acidosis; Anesthetics, Local; Animals; Blood Gas Analysis; Blood Pressure; Bupivacaine; Carbon Dioxi | 2004 |
Bupivacaine and ventricular fibrillation.
Topics: Acidosis; Anesthetics, Local; Bupivacaine; Humans; Microcirculation; Myocardium; Ventricular Fibrill | 2004 |
Use of thoracic epidural anesthesia for management of electrical storm: a case report.
Topics: Aged; Anesthesia, Epidural; Anesthetics, Local; Bupivacaine; Catheter Ablation; Humans; Male; Tachyc | 2005 |
Antiarrhythmic effects of targeted cardiac neuromodulation: is it time for clinical application?
Topics: Anesthesia, Epidural; Anesthetics, Local; Bupivacaine; Heart; Humans; Sympathetic Nervous System; Ta | 2005 |
Genetic and biophysical basis for bupivacaine-induced ST segment elevation and VT/VF. Anesthesia unmasked Brugada syndrome.
Topics: Anesthesia, General; Anesthetics, Local; Bupivacaine; Diagnosis, Differential; Electrocardiography; | 2006 |
Bupivacaine hastens the ischemia-induced decrease of the electrical ventricular fibrillation threshold.
Topics: Action Potentials; Animals; Blood Pressure; Bupivacaine; Cardiac Pacing, Artificial; Female; Heart; | 1995 |
Enhancement by ischemia of the risk of cardiac disorders, especially fibrillation, in regional anesthesia with bupivacaine.
Topics: Action Potentials; Anesthesia, Conduction; Animals; Blood Pressure; Bupivacaine; Electrocardiography | 1993 |
Cardiovascular and central nervous system effects of intravenous levobupivacaine and bupivacaine in sheep.
Topics: Anesthetics, Local; Animals; Arrhythmias, Cardiac; Blood Pressure; Brain; Bupivacaine; Cardiac Outpu | 1998 |
Lidocaine increases the ventricular fibrillation threshold during bupivacaine-induced cardiotoxicity in pigs.
Topics: Anesthetics, Combined; Anesthetics, Local; Animals; Anti-Arrhythmia Agents; Bupivacaine; Electrocard | 1998 |
Bupivacaine-induced seizures and ventricular fibrillation in a 13-year-old girl undergoing wound debridement.
Topics: Acute Disease; Adolescent; Anesthetics, Local; Anticonvulsants; Bupivacaine; Debridement; Diazepam; | 1998 |
Ventricular arrhythmias with or without programmed electrical stimulation after incremental overdosage with lidocaine, bupivacaine, levobupivacaine, and ropivacaine.
Topics: Amides; Anesthetics, Local; Animals; Bupivacaine; Cardiac Pacing, Artificial; Dogs; Drug Overdose; L | 2000 |
Ventricular fibrillation after accidental injection of bupivacaine into the pericardium.
Topics: Accidents; Bupivacaine; Humans; Injections; Male; Middle Aged; Pain, Postoperative; Pericardium; Ven | 1992 |
Electrophysiologic and arrhythmogenic effects of bupivacaine. A study with high-resolution ventricular epicardial mapping in rabbit hearts.
Topics: Animals; Bupivacaine; Electrophysiology; In Vitro Techniques; Rabbits; Tachycardia; Ventricular Fibr | 1992 |
Effect of epinephrine on central nervous system and cardiovascular system toxicity of bupivacaine in pigs.
Topics: Animals; Arrhythmias, Cardiac; Bupivacaine; Cardiovascular System; Central Nervous System; Dose-Resp | 1989 |
Differential depressant and electrophysiologic cardiotoxicity of local anesthetics: an experimental study with special reference to lidocaine and bupivacaine.
Topics: Animals; Bupivacaine; Electrocardiography; Heart; Hemodynamics; Injections, Intra-Arterial; Lidocain | 1986 |