bupivacaine has been researched along with Vaginismus in 1 studies
Bupivacaine: A widely used local anesthetic agent.
1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide : A piperidinecarboxamide obtained by formal condensation of the carboxy group of N-butylpipecolic acid with the amino group of 2,6-dimethylaniline.
bupivacaine : A racemate composed of equimolar amounts of dextrobupivacaine and levobupivacaine. Used (in the form of its hydrochloride hydrate) as a local anaesthetic.
Vaginismus: Recurrent or persistent involuntary SPASM of the outer muscles of the VAGINA, occurring during vaginal penetration.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Vaginal Botox injections for the treatment of vaginismus has received increasing attention since the technique was first described in a 1997 case report." | 6.47 | Vaginismus: review of current concepts and treatment using botox injections, bupivacaine injections, and progressive dilation with the patient under anesthesia. ( Pacik, PT, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Pacik, PT | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Open Label, Single Center, Pilot Study of the Use of BOTOX Injections, Sensorcaine Injections and Progressive Dilation Under Anesthesia for the Treatment of Primary Vaginismus[NCT01352546] | Phase 1 | 31 participants (Actual) | Interventional | 2010-08-31 | Completed | ||
| Study of the Effectiveness and Safety of Clostridium Botulinum Type A Neurotoxin Complex Injection in the Perineal Muscles in Resistant Cases of Vaginismus[NCT01859507] | 32 participants (Actual) | Interventional | 2013-01-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Patients need to be able to transition from the use of vaginal dilators to pain free intercourse, or to be able to continue using the #5 or #6 of 6 dilators in the absence of a partner. (NCT01352546)
Timeframe: one year
| Intervention | percentage of participants (Number) |
|---|---|
| BOTOX | 90.3 |
The primary outcome will be assessed by the couple. The couple is allowed to visit for follow up in a 4 weeks' time. Our inquiry is on the success of full and repeated penetration of the penis through the vaginal introitus into the vagina without or with acceptable pain. An acceptable outcome will be at least twice weekly successful sexual relationship that was completed without premature interruption from either partners. (NCT01859507)
Timeframe: Up to four weeks following the last session of the vaginal dilatation.
| Intervention | participants (Number) |
|---|---|
| Botox | 28 |
The level of comfort by the couple. The secondary outcome will be assessed by the couple. The couple is allowed to visit for follow up every three months for twelve months. Our inquiry is on the success of full and repeated penetration of the penis through the vaginal introitus into the vagina without or with acceptable pain. An acceptable outcome will be at least twice weekly successful sexual relationship that was completedwithout premature interruption from either partners. (NCT01859507)
Timeframe: Within twelve months after the Botox injection
| Intervention | participants (Number) |
|---|---|
| BOTOX Group | 28 |
1 review available for bupivacaine and Vaginismus
| Article | Year |
|---|---|
Vaginismus: review of current concepts and treatment using botox injections, bupivacaine injections, and progressive dilation with the patient under anesthesia.
Topics: Anesthetics, Local; Botulinum Toxins, Type A; Bupivacaine; Catheterization; Female; Humans; Injectio | 2011 |
Vaginismus: review of current concepts and treatment using botox injections, bupivacaine injections, and progressive dilation with the patient under anesthesia.
Topics: Anesthetics, Local; Botulinum Toxins, Type A; Bupivacaine; Catheterization; Female; Humans; Injectio | 2011 |
Vaginismus: review of current concepts and treatment using botox injections, bupivacaine injections, and progressive dilation with the patient under anesthesia.
Topics: Anesthetics, Local; Botulinum Toxins, Type A; Bupivacaine; Catheterization; Female; Humans; Injectio | 2011 |
Vaginismus: review of current concepts and treatment using botox injections, bupivacaine injections, and progressive dilation with the patient under anesthesia.
Topics: Anesthetics, Local; Botulinum Toxins, Type A; Bupivacaine; Catheterization; Female; Humans; Injectio | 2011 |