bupivacaine and Uterine Prolapse

bupivacaine has been researched along with Uterine Prolapse in 5 studies

Bupivacaine: A widely used local anesthetic agent.
1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide : A piperidinecarboxamide obtained by formal condensation of the carboxy group of N-butylpipecolic acid with the amino group of 2,6-dimethylaniline.
bupivacaine : A racemate composed of equimolar amounts of dextrobupivacaine and levobupivacaine. Used (in the form of its hydrochloride hydrate) as a local anaesthetic.

Uterine Prolapse: Downward displacement of the UTERUS. It is classified in various degrees: in the first degree the UTERINE CERVIX is within the vaginal orifice; in the second degree the cervix is outside the orifice; in the third degree the entire uterus is outside the orifice.

Research

Studies (5)

Authors

Clinical Trials (3)

Trial Overview

Trial Outcomes

1 Week Postoperative Pain Measured by the NRS

Postoperative Pain Measured by the Numeric Rating Scale 1 week after surgery. The Numeric Rating Scale is an 11 point scale ranging from 0-10 with higher scores indicating worse pain. (NCT03040011)
Timeframe: 1 week after surgery

6 Hour Postoperative Pain Measured by the NRS

"Postoperative pain as measured by the NRS at 6 hours after surgery. The Numeric Rating Scale is an 11 point scale ranging from 0-10 with higher scores indicating worse pain.~Of note, there is a typographical error in the protocol section and refers to this outcome as a NRS score at 3 hours postoperatively. The final IRB approved protocol is a 6 hour postoperative timepoint and this is the correct outcome reported here in the results section." (NCT03040011)
Timeframe: 6 hours postoperatively

Adverse Events

The number of adverse events in each study group was assessed and compared between study groups. An adverse event was described as any medical or surgical complication that occurred either intraoperatively or postoperatively. (NCT03040011)
Timeframe: 0-12 weeks postoperatively

Nausea and Vomiting Measured by the PONV Scale

Intensity of postoperative nausea and vomiting (PONV) measured by the PONV scale prior to discharge. The Postoperative Nausea and Vomiting Intensity Scale is a four-question assessment to measure clinically significant nausea and vomiting with a range from 0-7 with higher scores signifying more clinically significant nausea and vomiting. (NCT03040011)
Timeframe: 6 hours postoperatively

POD 1 Ibuprofen Consumption

The total amount of ibuprofen medication used on postoperative day 1. (NCT03040011)
Timeframe: Postoperative day 1

POD 1 Narcotic Consumption

The total amount of narcotic pain medication used on postoperative day 1 was calculated and measured in oral morphine equivalents. (NCT03040011)
Timeframe: Postoperative day 1

POD 2 Ibuprofen Consumption

The total amount of ibuprofen medication used on postoperative day 2. (NCT03040011)
Timeframe: Postoperative day 2

POD 2 Narcotic Consumption

The total amount of narcotic pain medication used on postoperative day 2 was calculated and measured in oral morphine equivalents. (NCT03040011)
Timeframe: Postoperative day 2

POD 2 Postoperative Pain Measured by the NRS

Postoperative Pain Measured by the NRS 2 days after surgery. The Numeric Rating Scale is an 11 point scale ranging from 0-10 with higher scores indicating worse pain. (NCT03040011)
Timeframe: 2 days after surgery

POD 3 Ibuprofen Consumption

The total amount of ibuprofen medication used on postoperative day 3. (NCT03040011)
Timeframe: Postoperative day 3

POD 3 Narcotic Consumption

The total amount of narcotic pain medication used on postoperative day 3 was calculated and measured in oral morphine equivalents. (NCT03040011)
Timeframe: Postoperative day 3

POD 3 Postoperative Pain Measured by the NRS

Postoperative Pain Measured by the NRS 3 days after surgery. The Numeric Rating Scale is an 11 point scale ranging from 0-10 with higher scores indicating worse pain. (NCT03040011)
Timeframe: 3 days after surgery

Postoperative Urinary Retention

Urinary retention was defined as the need to perform self-catheterization or have an indwelling catheter placed postoperatively. The proportion of patients with urinary retention was compared between groups. (NCT03040011)
Timeframe: 0-24 hours postoperatively

Primary Postoperative Pain Measured by the Numerical Rating Scale (NRS)

Postoperative pain measured by the numerical rating scale (NRS) at 24 hours postoperatively. The Numeric Rating Scale is an 11 point scale ranging from 0-10 with higher scores indicating worse pain. (NCT03040011)
Timeframe: 24 hours postoperatively

Proportion of Patients With Same Day Discharge

Same day discharge was defined as a patient being discharged on the same day as surgery and did not require an admission after surgery. The proportion of patients who were discharged on the day of surgery was compared between groups. (NCT03040011)
Timeframe: Day of surgery

Return to Baseline Activities Using the Activities Assessment Scale

"Resumed normal daily activities using the Activities Assessment Scale (AAS) by 1 week after surgery. The AAS is a 13-point scale on which patients rate their difficulty performing a range of activities from No difficulty to Not able to do it. A final score ranging from 0-100 is transformed, with higher numbers reflecting less difficulty with activities.~We defined return to normal as when a patient's postoperative AAS scores was at or greater than the baseline AAS score. We report the proportion of patients in each study arm who returned to baseline activity at each timepoint." (NCT03040011)
Timeframe: 1 week postoperative

Return to Baseline Activities Using the Activities Assessment Scale

"Resumed normal daily activities using the Activities Assessment Scale (AAS) by 12 weeks after surgery. The AAS is a 13-point scale on which patients rate their difficulty performing a range of activities from No difficulty to Not able to do it. A final score ranging from 0-100 is transformed, with higher numbers reflecting less difficulty with activities.~We defined return to normal as when a patient's postoperative AAS scores was at or greater than the baseline AAS score. We report the proportion of patients in each study arm who returned to baseline activity at each timepoint." (NCT03040011)
Timeframe: 12 weeks postoperative

Return to Baseline Activities Using the Activities Assessment Scale

"Resumed normal daily activities using the Activities Assessment Scale (AAS) by 2 weeks after surgery. The AAS is a 13-point scale on which patients rate their difficulty performing a range of activities from No difficulty to Not able to do it. A final score ranging from 0-100 is transformed, with higher numbers reflecting less difficulty with activities.~We defined return to normal as when a patient's postoperative AAS scores was at or greater than the baseline AAS score. We report the proportion of patients in each study arm who returned to baseline activity at each timepoint." (NCT03040011)
Timeframe: 2 week postoperative

Return to Baseline Activities Using the Activities Assessment Scale

"Resumed normal daily activities using the Activities Assessment Scale (AAS) by 6 weeks after surgery. The AAS is a 13-point scale on which patients rate their difficulty performing a range of activities from No difficulty to Not able to do it. A final score ranging from 0-100 is transformed, with higher numbers reflecting less difficulty with activities.~We defined return to normal as when a patient's postoperative AAS scores was at or greater than the baseline AAS score. We report the proportion of patients in each study arm who returned to baseline activity at each timepoint." (NCT03040011)
Timeframe: 6 weeks postoperative

Need for Intervention for Postoperative Pain

Need for intervention through the use of trigger point injection, referral to pelvic floor physical therapy, or reoperation (NCT02037061)
Timeframe: 6-weeks

Overall Pain Beyond Day of Discharge

Pain measured using the pain numeric rating scale from 0-10 (0=no pain, 10= worst pain imaginable) (NCT02037061)
Timeframe: 6 weeks

Postoperative Gluteal Pain

Pain measured using a pain numeric rating scale from 0 to 10 (0=no pain, 10= worst pain imaginable) (NCT02037061)
Timeframe: 6-weeks

Change in Pelvic Flore Disability Index - 20 (PFDI-20) Scores From Baseline to 12 Months

"Symptomatic success was assessed by the pelvic floor disability index (PFDI-20) questionnaire. The PFDI-20 has 20 items within 3 sub-scales of symptoms (total of 20 items). Each item produces a response of 0 to 4, the average response in each sub-scale is multiplied by 25 to obtain the sub-scale score (range 0 to 100). The total score is the sum of the three sub-scale scores with a range of 0-300. Higher value for a time-point score indicates a greater degree of symptom bother.~The difference in scores across the study time-points was calculated by subtracting the total score at baseline from the score at 12 months post-operation. A negative value for the difference in scores from baseline to 12 months indicates symptom improvement, where the more negative the difference in score is the greater the improvement in symptoms." (NCT03565640)
Timeframe: Baseline and Month 12

Change in Symptomatic Success - PFIQ-7 Scores

"Symptomatic success will be assessed by the Pelvic Floor Impact Questionnaire - 7 (PFIQ-7). The PFIQ-7 has 7 items for each of 3 sub-scales (total of 21 items). Each item produces a response of 0 to 3, the average response in each sub-scale is multiplied by 100/3 to obtain the total scale score (range 0 to 100). The total score is the sum of the three sub-scale scores with a range of 0-300. Higher value for a time-point score indicates a greater degree of symptom bother.~The difference in scores across the study time-points was calculated by subtracting the total score at baseline from the score at 12 months post-operation. A negative value for the difference in scores from baseline to 12 months indicates symptom improvement, where the more negative the difference in score is the greater the improvement in symptoms." (NCT03565640)
Timeframe: Baseline and Month 12

POP-Q Stage Score

The stage is assigned as follows: 0 if there is no prolapse at all, 1 if there is prolapse but the leading point is not within 1cm of the hymen, 2 if the leading point is within 1 cm of the hymen (from 1cm within the hymen to 1cm beyond the hymen), 3 if the leading point is more than 1cm from the hymen but less than 2cm from being completely prolapsed, and 4 if the leading point is within 2cm of being complete prolapsed. Therefore higher POP-Q stages correlate to a worse degree of prolapse than lower POP-Q stages. (NCT03565640)
Timeframe: at 12 MONTHS

Change in Buttock and Posterior Thigh Pain

This will be assessed using the numeric rating scale (NRS). The score is 0-10, with higher scores denoting a greater degree of pain. (NCT03565640)
Timeframe: postoperative 12 month

Trials

2 trials available for bupivacaine and Uterine Prolapse

Other Studies

3 other studies available for bupivacaine and Uterine Prolapse