Compounds > bupivacaine
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bupivacaine and Urination Disorders

bupivacaine has been researched along with Urination Disorders in 18 studies

Bupivacaine: A widely used local anesthetic agent.
1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide : A piperidinecarboxamide obtained by formal condensation of the carboxy group of N-butylpipecolic acid with the amino group of 2,6-dimethylaniline.
bupivacaine : A racemate composed of equimolar amounts of dextrobupivacaine and levobupivacaine. Used (in the form of its hydrochloride hydrate) as a local anaesthetic.

Urination Disorders: Abnormalities in the process of URINE voiding, including bladder control, frequency of URINATION, as well as the volume and composition of URINE.

Research Excerpts

ExcerptRelevanceReference
"Phenazopyridine has been associated with methemoglobinemia in patients who have received an overdose, have decreased renal function, or are discovered to be unusually susceptible to the drug (ie, they may have an undetected NADH methemoglobin reductase deficiency)."3.68Acquired methemoglobinemia from multiple oxidants. ( Bailey, MK; Baker, JD; Conroy, JM; Dorman, BH; Martin, WJ, 1993)
"This study evaluates the efficacy and side effects of a low dose of epidural morphine combined with clonidine for postoperative pain relief after lumbar disc surgery."2.70Epidural administration of low-dose morphine combined with clonidine for postoperative analgesia after lumbar disc surgery. ( Bonhomme, V; Brichant, JF; Dewandre, PY; Doll, A; Ghassempour, K; Hans, P, 2002)
"Following epidural morphine, postoperative pain was les frequent, less intense and of shorter duration, use of analgesics and sedative was less frequent; and the postoperative feeling of well-being rated better than after systemic morphine or epidural saline."2.65Epidural morphine for postoperative analgesia: a double-blind study. ( Lanz, E; Riess, W; Sommer, U; Theiss, D, 1982)
" However, adverse side effects of opioids include respiratory depression, urinary retention, pruritus, vomiting, nausea, constipation, and increased risk of falls."1.43Reducing Opioid Adverse Events: A Safe Way to Improve Outcomes. ( McCarus, SD; Redan, JA; Reeder, S; Wells, T, 2016)
"Arterial hypotension was a troublesome complication with all techniques although stability of arterial pressure was more easily achieved with a continuous infusion technique."1.25Postoperative extradural analgesia following thoracic surgery: a feasibility study. ( Cameron, JD; Diamond, AW; Griffiths, DP, 1975)

Research

Studies (18)

TimeframeStudies, this research(%)All Research%
pre-199011 (61.11)18.7374
1990's2 (11.11)18.2507
2000's3 (16.67)29.6817
2010's2 (11.11)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Redan, JA1
Wells, T1
Reeder, S1
McCarus, SD1
Wuethrich, PY1
Metzger, T1
Mordasini, L1
Kessler, TM1
Curatolo, M1
Burkhard, FC1
Breebaart, MB1
Vercauteren, MP1
Hoffmann, VL1
Adriaensen, HA1
Rabadán Díaz, JV1
López Moreno, JA1
Soria Quiles, A1
Del Pino Moreno, AL1
Lanz, E2
Theiss, D1
Riess, W1
Sommer, U1
Conroy, JM1
Baker, JD1
Martin, WJ1
Bailey, MK1
Dorman, BH1
Bonhomme, V1
Doll, A1
Dewandre, PY1
Brichant, JF1
Ghassempour, K1
Hans, P1
Moir, DD1
Slater, PJ1
Thorburn, J1
McLaren, R1
Moodie, J1
Kortum, K1
Rössler, B1
Nolte, H1
Bridenbaugh, LD1
Griffiths, DP1
Diamond, AW1
Cameron, JD1
Grab, BM1
Pitkänen, M1
Rosenberg, PH1
Axelsson, K1
Möllefors, K1
Olsson, JO1
Lingårdh, G1
Widman, B1
Worthley, LI1
Crawford, JS1
Nash, TG1
Addison, NV1
Brear, FA1
Budd, K1
Whittaker, M1

Clinical Trials (6)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Liposomal Bupivacaine Versus Bupivacaine for Postoperative Analgesia Following Video-assisted Thoracoscopic Surgery.[NCT03036085]Phase 2/Phase 3200 participants (Anticipated)Interventional2017-02-28Not yet recruiting
Unilateral Versus Bilateral Spinal Anesthesia in Day Case Procedures: Difference in Block Characteristics, Micturition Quality and Discharge Time[NCT01877356]25 participants (Actual)Interventional2012-12-31Terminated (stopped due to intermittent evaluation of results: high incendence of complications)
Influence of Spinal or Intravenous Dexmedetomidine on Spinal Anesthesia With Chloroprocaine and Bladder Function in Day-case Surgery. A Double Blind Randomized Study.[NCT02282319]Phase 4150 participants (Anticipated)Interventional2014-10-31Completed
A Prospective Triple-masked Randomized Controlled Trial Measuring Analgesia Duration of Dexamethasone, Buprenorphine, or Clonidine With Ropivacaine for Interscalene Nerve Block[NCT03117140]Phase 4160 participants (Actual)Interventional2013-12-31Completed
Does Thoracic Epidural Analgesia Influence Urinary Micturition by Patients Undergoing Thoracic Surgery? An Observational, Prospective Study[NCT00976313]26 participants (Actual)Observational2009-09-30Completed
Evaluation of the Compuflo Epidural Instrument for Thoracic Epidural Space Identification[NCT03376256]2 participants (Actual)Interventional2018-07-11Terminated (stopped due to Difficulty in participant recruitment)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Block Set up Time

Patients are assessed from needle removal to when they are no longer able to feel cold on the blocked extremity (NCT03117140)
Timeframe: Day one

Interventionminutes (Median)
Plain Ropivacaine6
Ropivacaine + Buprenorphine3
Ropivacaine + Clonidine6
Ropivacaine + Dexamethasone4.5

Duration of Analgesia

Patients are called 1-3 days post-operatively to assess when the analgesia of their nerve block wore off (NCT03117140)
Timeframe: 1-3 days post-operative

Interventionminutes (Median)
Plain Ropivacaine911
Ropivacaine + Buprenorphine1026.5
Ropivacaine + Clonidine1181
Ropivacaine + Dexamethasone982

Motor Duration of Block

Patients are called 1-3 days post-operatively to assess when motor component of their nerve block wore off (NCT03117140)
Timeframe: Day 1-3

Interventionminutes (Median)
Plain Ropivacaine1120
Ropivacaine + Buprenorphine1198
Ropivacaine + Clonidine1090
Ropivacaine + Dexamethasone1143.5

Number of Patient With Blood Pressure Changes in the Second Stage Recovery Area

Blood pressure changes in Second Stage Recovery Area for patients was looked at (NCT03117140)
Timeframe: Post-op Day 0 (baseline)

InterventionParticipants (Count of Participants)
Plain Ropivacaine5
Ropivacaine + Buprenorphine1
Ropivacaine + Clonidine5
Ropivacaine + Dexamethasone0

Number of Patients Reporting Itching at Home

Patients are called 1-3 days post-operatively to assess if they had any side effects of the adjuvants such as nausea, vomiting or itching. There blood pressure is looked at pre-op and compared to post-op. Any prolonged PACU (Post Anesthesia Care Unit) stay for sedation is recorded. (NCT03117140)
Timeframe: 1-3 days

InterventionParticipants (Count of Participants)
Plain Ropivacaine1
Ropivacaine + Buprenorphine2
Ropivacaine + Clonidine2
Ropivacaine + Dexamethasone0

Number of Patients Reporting Itching in the PACU

Patients itching was assessed post-op in the PACU. (NCT03117140)
Timeframe: Post-op day 0 (baseline)

InterventionParticipants (Count of Participants)
Plain Ropivacaine5
Ropivacaine + Buprenorphine2
Ropivacaine + Clonidine6
Ropivacaine + Dexamethasone3

Number of Patients Reporting Nausea at Home

Patients are called 1-3 days post-operatively to assess if they had any side effects of the adjuvants such as nausea, vomiting or itching. There blood pressure is looked at pre-op and compared to post-op. Any prolonged PACU (Post Anesthesia Care Unit) stay for sedation is recorded. (NCT03117140)
Timeframe: 1-3 days

InterventionParticipants (Count of Participants)
Plain Ropivacaine4
Ropivacaine + Buprenorphine9
Ropivacaine + Clonidine2
Ropivacaine + Dexamethasone3

Number of Patients Reporting Nausea in the PACU

PACU (Post-Anesthesia Care Unit) assessment of nausea (NCT03117140)
Timeframe: Post-op day 0 (Baseline)

InterventionParticipants (Count of Participants)
Plain Ropivacaine4
Ropivacaine + Buprenorphine9
Ropivacaine + Clonidine2
Ropivacaine + Dexamethasone9

Number of Patients Vomiting in the PACU (Post-Anesthesia Care Unit)

Vomiting in PACU (Post-Anesthesia Care Unit) for patients was looked at (NCT03117140)
Timeframe: Post-op Day 0 (Baseline)

InterventionParticipants (Count of Participants)
Plain Ropivacaine0
Ropivacaine + Buprenorphine1
Ropivacaine + Clonidine0
Ropivacaine + Dexamethasone0

Number of Patients With Blood Pressure (BP) Changes in the PACU

Blood pressure changes in PACU (Post-Anesthesia Care Unit) for patients was looked at (NCT03117140)
Timeframe: Post-op Day 0 (baseline)

InterventionParticipants (Count of Participants)
Plain Ropivacaine8
Ropivacaine + Buprenorphine3
Ropivacaine + Clonidine7
Ropivacaine + Dexamethasone2

Pain Score Reported by Patients at First Phone Call

Patients are called 1-3 days post-operatively to assess pain. Pain score is 0-10 scale with 0 is no pain and 10 is most severe pain. (NCT03117140)
Timeframe: Day 1-3

Interventionunits on a scale (Median)
Plain Ropivacaine4
Ropivacaine + Buprenorphine3
Ropivacaine + Clonidine4
Ropivacaine + Dexamethasone3

Patient Reporting Vomiting at Home

Patients are called 1-3 days post-operatively to assess if they had any side effects of the adjuvants such as nausea, vomiting or itching. There blood pressure is looked at pre-op and compared to post-op. Any prolonged PACU (Post Anesthesia Care Unit) stay for sedation is recorded. (NCT03117140)
Timeframe: 1-3 days

InterventionParticipants (Count of Participants)
Plain Ropivacaine0
Ropivacaine + Buprenorphine3
Ropivacaine + Clonidine2
Ropivacaine + Dexamethasone1

Sensory Duration of Block

Patients are called 1-3 days post-operatively to assess when the sensory component of their nerve block wore off (NCT03117140)
Timeframe: Day 1-3

Interventionminutes (Median)
Plain Ropivacaine923.5
Ropivacaine + Buprenorphine982
Ropivacaine + Clonidine940.5
Ropivacaine + Dexamethasone1066

Surgical Length

Surgical length was recorded (NCT03117140)
Timeframe: Post op Day 0 (Baseline)

Interventionminutes (Median)
Plain Ropivacaine68.5
Ropivacaine + Buprenorphine65
Ropivacaine + Clonidine73.5
Ropivacaine + Dexamethasone71

Surgical Position

Surgical position was recorded (NCT03117140)
Timeframe: Post-op Day 0 (Baseline)

,,,
InterventionParticipants (Count of Participants)
Beach ChairLateralSupine
Plain Ropivacaine3820
Ropivacaine + Buprenorphine3163
Ropivacaine + Clonidine3172
Ropivacaine + Dexamethasone3262

Percent of Successful Performance of Thoracic Epidural Anesthesia Using Loss of Resistance Technique

Percent of thoracic epidural anesthesia procedures using LOR that result in a loss of sensation to cold in at least one dermatome, either unilateral or bilateral (NCT03376256)
Timeframe: Day 1

InterventionPercent of successful performance (Number)
Phase A - Thoracic ES With LORNA

Pressure Levels in Thoracic Epidural Space

The Compuflo Epidural Instrument measures the pressure levels in millimeters of mercury (mmHg) in the thoracic epidural space (NCT03376256)
Timeframe: Day 1

InterventionmmHg (Number)
Phase A - Thoracic ES With LORNA

Trials

8 trials available for bupivacaine and Urination Disorders

ArticleYear
Influence of epidural mixture and surgery on bladder function after open renal surgery: a randomized clinical trial.
    Anesthesiology, 2013, Volume: 118, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Analgesia, Epidural; Analgesics, Opioid; Anesthetics, Local; Bupivac

2013
Urinary bladder scanning after day-case arthroscopy under spinal anaesthesia: comparison between lidocaine, ropivacaine, and levobupivacaine.
    British journal of anaesthesia, 2003, Volume: 90, Issue:3

    Topics: Adolescent; Adult; Amides; Anesthesia, Spinal; Anesthetics, Local; Arthroscopy; Bupivacaine; Double-

2003
Urinary bladder scanning after day-case arthroscopy under spinal anaesthesia: comparison between lidocaine, ropivacaine, and levobupivacaine.
    British journal of anaesthesia, 2003, Volume: 90, Issue:3

    Topics: Adolescent; Adult; Amides; Anesthesia, Spinal; Anesthetics, Local; Arthroscopy; Bupivacaine; Double-

2003
Urinary bladder scanning after day-case arthroscopy under spinal anaesthesia: comparison between lidocaine, ropivacaine, and levobupivacaine.
    British journal of anaesthesia, 2003, Volume: 90, Issue:3

    Topics: Adolescent; Adult; Amides; Anesthesia, Spinal; Anesthetics, Local; Arthroscopy; Bupivacaine; Double-

2003
Urinary bladder scanning after day-case arthroscopy under spinal anaesthesia: comparison between lidocaine, ropivacaine, and levobupivacaine.
    British journal of anaesthesia, 2003, Volume: 90, Issue:3

    Topics: Adolescent; Adult; Amides; Anesthesia, Spinal; Anesthetics, Local; Arthroscopy; Bupivacaine; Double-

2003
Epidural morphine for postoperative analgesia: a double-blind study.
    Anesthesia and analgesia, 1982, Volume: 61, Issue:3

    Topics: Adult; Aged; Aging; Bupivacaine; Double-Blind Method; Drug Evaluation; Epidural Space; Female; Human

1982
Epidural administration of low-dose morphine combined with clonidine for postoperative analgesia after lumbar disc surgery.
    Journal of neurosurgical anesthesiology, 2002, Volume: 14, Issue:1

    Topics: Adjuvants, Anesthesia; Adult; Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesics; Analge

2002
Extradural analgesia in obstetrics: a controlled trial of carbonated lignocaine and bupivacaine hydrochloride with or without adrenaline.
    British journal of anaesthesia, 1976, Volume: 48, Issue:2

    Topics: Anesthesia, Epidural; Anesthesia, Obstetrical; Back Pain; Bupivacaine; Epinephrine; Female; Headache

1976
[Micturition disorders following spinal anesthesia of different durations of action (lidocaine 2% versus bupivacaine 0.5%)].
    Der Anaesthesist, 1992, Volume: 41, Issue:4

    Topics: Adult; Anesthesia, Spinal; Bupivacaine; Double-Blind Method; Female; Germany; Humans; Lidocaine; Mal

1992
Minor complications following anaesthesia in young adults for orthopaedic surgery of the lower extremity.
    Annales chirurgiae et gynaecologiae, 1987, Volume: 76, Issue:2

    Topics: Adolescent; Adult; Anesthesia, General; Anesthesia, Spinal; Back Pain; Bupivacaine; Female; Headache

1987
Bladder function in spinal anaesthesia.
    Acta anaesthesiologica Scandinavica, 1985, Volume: 29, Issue:3

    Topics: Aged; Anesthesia, Spinal; Bupivacaine; Humans; Isometric Contraction; Male; Middle Aged; Muscles; Ra

1985

Other Studies

10 other studies available for bupivacaine and Urination Disorders

ArticleYear
Reducing Opioid Adverse Events: A Safe Way to Improve Outcomes.
    Surgical technology international, 2016, Volume: 28

    Topics: Accidental Falls; Adult; Aged; Bupivacaine; Colonoscopy; Drug Substitution; Female; Florida; Hernior

2016
[Neurological deficit during recovery from cesarean section under spinal anesthesia after the appearance of undiagnosed multiple sclerosis].
    Revista espanola de anestesiologia y reanimacion, 2006, Volume: 53, Issue:10

    Topics: Adult; Anesthesia, Obstetrical; Anesthesia, Spinal; Anesthetics, Local; Bupivacaine; Cesarean Sectio

2006
Acquired methemoglobinemia from multiple oxidants.
    Southern medical journal, 1993, Volume: 86, Issue:10

    Topics: Administration, Topical; Adult; Analgesia, Epidural; Blood Gas Analysis; Bupivacaine; Cytochrome-B(5

1993
[Morbidity following spinal anaesthesia (author's transl)].
    Der Anaesthesist, 1979, Volume: 28, Issue:1

    Topics: Adult; Aged; Anesthesia, Spinal; Bupivacaine; Fecal Incontinence; Female; Headache; Humans; Male; Mi

1979
Catheterization after long- and short-acting local anesthetics for continuous caudal block for vaginal delivery.
    Anesthesiology, 1977, Volume: 46, Issue:5

    Topics: Anesthesia, Caudal; Anesthesia, Epidural; Anesthesia, Obstetrical; Anesthetics, Local; Bupivacaine;

1977
Postoperative extradural analgesia following thoracic surgery: a feasibility study.
    British journal of anaesthesia, 1975, Volume: 47, Issue:1

    Topics: Aged; Anesthesia, Epidural; Bupivacaine; Epinephrine; Female; Fentanyl; Halothane; Humans; Hypotensi

1975
Thoracic epidural in the management of chest trauma. A study of 161 cases.
    Intensive care medicine, 1985, Volume: 11, Issue:6

    Topics: Adolescent; Adult; Aged; Anesthesia, Epidural; Bupivacaine; Epinephrine; Female; Heart Arrest; Human

1985
The second thousand epidural blocks in an obstetric hospital practice.
    British journal of anaesthesia, 1972, Volume: 44, Issue:12

    Topics: Anesthesia, Epidural; Anesthesia, Obstetrical; Back Pain; Blood Pressure; Bupivacaine; Delivery, Obs

1972
Epidural analgesia by the obstetrician: a personal series.
    Guy's Hospital reports, 1973, Volume: 122, Issue:3-4

    Topics: Adult; Anesthesia, Epidural; Anesthesia, Obstetrical; Back Pain; Breech Presentation; Bupivacaine; C

1973
Epidural analgesia following cholecystectomy.
    The British journal of surgery, 1974, Volume: 61, Issue:10

    Topics: Analgesia; Anesthesia, Epidural; Blood Pressure; Bupivacaine; Catheterization; Cholecystectomy; Coug

1974