bupivacaine and Urinary Retention studies

Bupivacaine: A widely used local anesthetic agent.
1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide : A piperidinecarboxamide obtained by formal condensation of the carboxy group of N-butylpipecolic acid with the amino group of 2,6-dimethylaniline.
bupivacaine : A racemate composed of equimolar amounts of dextrobupivacaine and levobupivacaine. Used (in the form of its hydrochloride hydrate) as a local anaesthetic.

Urinary Retention: Inability to empty the URINARY BLADDER with voiding (URINATION).

Research Excerpts

Excerpt	Relevance	Reference
"We have conducted a double-blind, randomized study in two groups of 20 patients each, undergoing hip surgery during spinal anaesthesia, to compare the incidence of urinary retention after spinal morphine or clonidine."	9.08	Spinal clonidine produces less urinary retention than spinal morphine. ( Bonnet, F; Gentili, M, 1996)
"Urinary retention, overflow incontinence, and subsequent detrusor atony were observed following surgery in which a morphine with bupivacaine epidural injection was used for perioperative analgesia."	7.70	Postoperative urinary retention in a dog following morphine with bupivacaine epidural analgesia. ( Herperger, LJ, 1998)
"We have conducted a double-blind, randomized study in two groups of 20 patients each, undergoing hip surgery during spinal anaesthesia, to compare the incidence of urinary retention after spinal morphine or clonidine."	5.08	Spinal clonidine produces less urinary retention than spinal morphine. ( Bonnet, F; Gentili, M, 1996)
"Urinary retention, overflow incontinence, and subsequent detrusor atony were observed following surgery in which a morphine with bupivacaine epidural injection was used for perioperative analgesia."	3.70	Postoperative urinary retention in a dog following morphine with bupivacaine epidural analgesia. ( Herperger, LJ, 1998)
"Urinary retention was absent."	2.82	Randomized comparison of the feasibility of three anesthetic techniques for day-case open inguinal hernia repair. ( Harju, J; Kairaluoma, P; Pere, P; Remes, V; Rosenberg, PH; Turunen, P, 2016)
" Study variables included pain intensity on a visual analog scale every 4 hours, need for rescue analgesia (morphine), complications and adverse events within 5 postoperative days."	2.74	[Epidural analgesia versus femoral or femoral-sciatic nerve block after total knee replacement: comparison of efficacy and safety]. ( Bartrons Vilarnau, R; Bisbe Vives, E; Castillo Monsegur, J; Escolano Villén, F; Ginés Cespedosa, A; Montes Pérez, A; Santiveri Papiol, X, 2009)
"The purpose of this retrospective study was to determine whether epidural fentanyl-bupivacaine patient-controlled analgesia (PCA) was more efficacious and had fewer adverse effects than epidural or intravenous morphine PCA."	2.71	Efficacy and adverse effects of patient-controlled epidural or intravenous analgesia after major surgery. ( Hu, JS; Liew, C; Lui, PW; Teng, YH; Tsai, SK, 2004)
"Morphine was also associated with a significantly greater incidence of urinary retention than pethidine (p = 0."	2.69	Side-effects of epidural infusions of opioid bupivacaine mixtures. ( Gedney, JA; Liu, EH, 1998)
"Postoperative pain was assessed by means of a modified Objective Pain Score and analgesia was administered if this score exceeded four."	2.69	The effect of ketamine on 0.25% and 0.125% bupivacaine for caudal epidural blockade in children. ( Aldridge, LM; Doyle, E; Findlow, D; Johnston, P, 1999)
"Pruritus was observed in 29% of patients and was more common in diplegia than quadriplegia (48% vs 12."	1.30	Epidural analgesia in children with cerebral palsy. ( Brenn, BR; Brislin, RP; Rose, JB, 1998)
"Urinary retention was seen in 11% of patients and pruritus in 10%."	1.29	An audit of extradural infusion analgesia in children using bupivacaine and diamorphine. ( Lloyd-Thomas, AR; Wilson, PT, 1993)

Research

Studies (30)

Authors

Clinical Trials (5)

Trial Overview

Trial Outcomes

Hospital Stay

Number of Patients With Dizziness Events

Timeframe	Studies, this research(%)	All Research%
pre-1990	1 (3.33)	18.7374
1990's	16 (53.33)	18.2507
2000's	5 (16.67)	29.6817
2010's	6 (20.00)	24.3611
2020's	2 (6.67)	2.80

Authors	Studies
Slaven, SE	1
Dedeogullari, ES	1
Parks, NL	1
Sershon, RA	1
Fricka, KB	1
Hamilton, WG	1
Maheshwari, D	1
Sierra, T	1
Leung, K	1
Hall, C	1
Flynn, M	1
Mahan, MC	1
Jildeh, TR	1
Tenbrunsel, TN	1
Davis, JJ	1
Kalchofner Guerrero, KS	1
Guerrero, TG	1
Schweizer-Kölliker, M	1
Ringer, SK	1
Hässig, M	1
Bettschart-Wolfensberger, R	1
Pere, P	1
Harju, J	1
Kairaluoma, P	1
Remes, V	1
Turunen, P	1
Rosenberg, PH	2
Santiveri Papiol, X	1
Castillo Monsegur, J	1
Bisbe Vives, E	1
Ginés Cespedosa, A	1
Bartrons Vilarnau, R	1
Montes Pérez, A	1
Escolano Villén, F	1
Bhattacharya, P	1
Mandal, MC	1
Mukhopadhyay, S	1
Das, S	1
Pal, PP	1
Basu, SR	1
Mulroy, MF	1
Alley, EA	1
Wuethrich, PY	1
Metzger, T	1
Mordasini, L	1
Kessler, TM	1
Curatolo, M	1
Burkhard, FC	1
Teng, YH	1
Hu, JS	1
Tsai, SK	1
Liew, C	1
Lui, PW	1
Wofford, K	1
Kase, S	1
Moore, J	1
Kelly, J	1
Pellegrini, JE	1
Kim, J	1
Lee, DS	1
Jang, SM	1
Shim, MC	1
Jee, DL	1
Ng, KO	1
Tsou, MY	1
Chao, YH	1
Mui, WC	1
Chow, LH	1
Chan, KH	1
Niemi, L	1
Pitkänen, M	1
Tuominen, M	1
Fleischer, M	1
Marini, CP	1
Statman, R	1
Capella, J	1
Shevde, K	1
Baumgarten, RK	1
Wilson, PT	1
Lloyd-Thomas, AR	1
Gentili, M	1
Bonnet, F	1
Olofsson, CI	1
Ekblom, AO	1
Ekman-Ordeberg, GE	1
Irestedt, LE	1
Pappalardo, GB	1
Aranzulla, F	1
Di Santo, S	1
Barrera, A	1
Beltrutti, D	1
Milford, MA	1
Paluch, TA	1
Herperger, LJ	1
Brenn, BR	1
Brislin, RP	1
Rose, JB	1
Gedney, JA	1
Liu, EH	1
Moriarty, A	1
Bimston, DN	1
McGee, JP	1
Liptay, MJ	1
Fry, WA	1
Johnston, P	1
Findlow, D	1
Aldridge, LM	1
Doyle, E	1
Davis, S	1
Erskine, R	1
James, MF	1
Finley, RK	1
Miller, SF	1
Jones, LM	1
Greenbarg, PE	1
Brown, MD	1
Pallares, VS	1
Tompkins, JS	1
Mann, NH	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
The Effect of Pudendal Blocks on Voiding Dysfunction Following Slings[NCT03353714]		90 participants (Actual)	Interventional	2017-10-01	Completed
A Randomized, Controlled, Double-Blind Trial of 3 Local Anesthetics for Spinal Anesthesia in Primary Total Hip Arthroplasty to Compare the Percentage of Patients in Each Group With Early Ambulation[NCT03948386]	Phase 4	159 participants (Actual)	Interventional	2019-05-13	Completed
Ligasure™ Versus Diathermy Haemorrhoidectomy Under Spinal or Local Anaesthesia With Ropivacaine. A Randomized Study With One Year Follow-up[NCT00617448]		81 participants (Actual)	Interventional	2005-05-31	Completed
Investigation of Pharmacokinetics and Pharmacodynamics of Epidural Methadone in Healthy Volunteers[NCT03525509]	Early Phase 1	13 participants (Actual)	Interventional	2018-06-04	Completed
Evaluating General Anesthesia With Erector Spinae Plane Block vs. Spinal Anesthesia With Erector Spinae Plane Block in Lumbar Decompression Surgeries[NCT05444751]	Phase 3	142 participants (Anticipated)	Interventional	2022-03-22	Enrolling by invitation
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Intervention	hours (Median)
Isobaric Bupivacaine	26
Hyperbaric Bupivacaine	26
Isobaric Mepivacaine	22

number of patients with dizziness when transitioning from lying down to sitting or standing (NCT03948386)
Timeframe: Postoperative day 2

Number of Patients With Transient Neurological Symptoms (TNS)

Intervention	Participants (Count of Participants)
Isobaric Bupivacaine	11
Hyperbaric Bupivacaine	7
Isobaric Mepivacaine	9

Number of patients with TNS events occurring. Transient neurological symptoms were defined as new onset of back, buttock, or thigh pain occurring after spinal anesthesia. (NCT03948386)
Timeframe: Postoperative days 0-2

Number of Patients With Urinary Retention Events

Intervention	Participants (Count of Participants)
Isobaric Bupivacaine	2
Hyperbaric Bupivacaine	6
Isobaric Mepivacaine	5

number of patients with inability to urinate within 8 hours of surgery OR a report of distended or painful bladder occurring on postoperative day 0 or 1, either by patient report or on palpation by nursing (NCT03948386)
Timeframe: postoperative day 1

Percentage Ambulating Early After Spinal Anesthesia

Intervention	Participants (Count of Participants)
Isobaric Bupivacaine	6
Hyperbaric Bupivacaine	8
Isobaric Mepivacaine	5

Is there a difference between isobaric mepivacaine, hyperbaric bupivacaine, and isobaric bupivacaine when used for spinal anesthesia in primary total hip replacement in percentage of patients that can ambulate within 3.5 hours after spinal anesthesia? (NCT03948386)
Timeframe: 3.5 hours

Return of Motor Function of the Thigh and Lower Leg

Intervention	Participants (Count of Participants)
Isobaric Bupivacaine	9
Hyperbaric Bupivacaine	20
Isobaric Mepivacaine	35

time to return of motor function of the thigh and lower leg (NCT03948386)
Timeframe: Postoperative day 0 (day of surgery)

Article	Year
Effect of Pudendal Blockade on Bladder Emptying After Midurethral Sling: A Randomized Controlled Trial. Female pelvic medicine & reconstructive surgery, 2021, 02-01, Volume: 27, Issue:2 Topics: Adult; Anesthetics, Local; Bupivacaine; Double-Blind Method; Female; Humans; Middle Aged; Nerve Bloc	2021
Incidence of delayed hair re-growth, pruritus, and urinary retention after epidural anaesthesia in dogs. Tierarztliche Praxis. Ausgabe K, Kleintiere/Heimtiere, 2014, Apr-16, Volume: 42, Issue:2 Topics: Analgesics, Opioid; Anesthesia, Epidural; Animals; Bupivacaine; Dog Diseases; Dogs; Female; Hair; Ha	2014
Randomized comparison of the feasibility of three anesthetic techniques for day-case open inguinal hernia repair. Journal of clinical anesthesia, 2016, Volume: 34 Topics: Adult; Aged; Ambulatory Surgical Procedures; Amides; Anesthesia; Anesthesia Recovery Period; Anesthe	2016
[Epidural analgesia versus femoral or femoral-sciatic nerve block after total knee replacement: comparison of efficacy and safety]. Revista espanola de anestesiologia y reanimacion, 2009, Volume: 56, Issue:1 Topics: Aged; Aged, 80 and over; Analgesia, Epidural; Anesthetics, Local; Arthroplasty, Replacement, Knee; B	2009
Unilateral paravertebral block: an alternative to conventional spinal anaesthesia for inguinal hernia repair. Acta anaesthesiologica Scandinavica, 2010, Volume: 54, Issue:2 Topics: Adolescent; Adult; Aged; Analgesics; Anesthesia Recovery Period; Anesthesia, Spinal; Anesthetics, In	2010
Influence of epidural mixture and surgery on bladder function after open renal surgery: a randomized clinical trial. Anesthesiology, 2013, Volume: 118, Issue:1 Topics: Adult; Aged; Aged, 80 and over; Analgesia, Epidural; Analgesics, Opioid; Anesthetics, Local; Bupivac	2013
Efficacy and adverse effects of patient-controlled epidural or intravenous analgesia after major surgery. Chang Gung medical journal, 2004, Volume: 27, Issue:12 Topics: Aged; Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthetics, Intraveno	2004
The effect of Pencan needle orientation on spinal anesthesia outcomes. AANA journal, 2005, Volume: 73, Issue:2 Topics: Adjuvants, Anesthesia; Adult; Ambulatory Surgical Procedures; Anesthesia, Spinal; Anesthetics, Local	2005
The effect of pudendal block on voiding after hemorrhoidectomy. Diseases of the colon and rectum, 2005, Volume: 48, Issue:3 Topics: Adult; Aged; Anesthesia, Spinal; Anesthetics, Local; Bupivacaine; Elective Surgical Procedures; Fema	2005
Urinary catheterization may not be necessary in minor surgery under spinal anesthesia with long-acting local anesthetics. Acta anaesthesiologica Taiwanica : official journal of the Taiwan Society of Anesthesiologists, 2006, Volume: 44, Issue:4 Topics: Adult; Anesthesia, Spinal; Anesthetics, Local; Bupivacaine; Female; Humans; Incidence; Male; Minor S	2006
Technical problems and side effects associated with continuous intrathecal or epidural post-operative analgesia in patients undergoing hip arthroplasty. European journal of anaesthesiology, 1994, Volume: 11, Issue:6 Topics: Aged; Aged, 80 and over; Analgesia; Analgesia, Epidural; Anesthesia, Spinal; Bupivacaine; Catheteriz	1994
Local anesthesia is superior to spinal anesthesia for anorectal surgical procedures. The American surgeon, 1994, Volume: 60, Issue:11 Topics: Adult; Aged; Aged, 80 and over; Anal Canal; Anesthesia Recovery Period; Anesthesia, Local; Anesthesi	1994
Spinal clonidine produces less urinary retention than spinal morphine. British journal of anaesthesia, 1996, Volume: 76, Issue:6 Topics: Adult; Aged; Anesthesia, Spinal; Anesthetics, Local; Bupivacaine; Clonidine; Double-Blind Method; Fe	1996
Post-partum urinary retention: a comparison between two methods of epidural analgesia. European journal of obstetrics, gynecology, and reproductive biology, 1997, Volume: 71, Issue:1 Topics: Adult; Analgesia, Epidural; Analgesia, Obstetrical; Bupivacaine; Epinephrine; Female; Humans; Labor,	1997
Side-effects of epidural infusions of opioid bupivacaine mixtures. Anaesthesia, 1998, Volume: 53, Issue:12 Topics: Aged; Aged, 80 and over; Analgesia, Epidural; Analgesics, Opioid; Anesthetics, Local; Arthroplasty,	1998
Postoperative extradural infusions in children: preliminary data from a comparison of bupivacaine/diamorphine with plain ropivacaine. Paediatric anaesthesia, 1999, Volume: 9, Issue:5 Topics: Amides; Analgesics, Opioid; Anesthetics, Local; Bupivacaine; Child; Costs and Cost Analysis; Drug Co	1999
Continuous paravertebral extrapleural infusion for post-thoracotomy pain management. Surgery, 1999, Volume: 126, Issue:4 Topics: Anesthesia, Epidural; Anesthetics, Local; Bupivacaine; Catheterization; Fentanyl; Forced Expiratory	1999
The effect of ketamine on 0.25% and 0.125% bupivacaine for caudal epidural blockade in children. Paediatric anaesthesia, 1999, Volume: 9, Issue:1 Topics: Acetaminophen; Analgesia, Epidural; Analgesics; Analgesics, Non-Narcotic; Anesthesia Recovery Period	1999
A comparison of spinal and epidural anaesthesia for hip arthroplasty. Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1992, Volume: 39, Issue:6 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anesthesia, Epidural; Anesthesia, Intravenous; Anesthesi	1992

Article	Year
Spinal Anesthesia for Primary Hip and Knee Arthroplasty: Comparative Rates of Transient Neurological Symptoms and Urinary Retention Using Lidocaine, Mepivacaine, and Bupivacaine. The Journal of arthroplasty, 2023, Volume: 38, Issue:6S Topics: Anesthesia, Spinal; Anesthetics, Local; Arthroplasty, Replacement, Knee; Bupivacaine; Humans; Lidoca	2023
Mepivacaine Spinal Anesthesia Facilitates Rapid Recovery in Total Knee Arthroplasty Compared to Bupivacaine. The Journal of arthroplasty, 2018, Volume: 33, Issue:6 Topics: Aged; Analgesics, Opioid; Anesthesia, General; Anesthesia, Spinal; Anesthetics, Local; Arthroplasty,	2018
Spinal anesthesia and postoperative urinary retention in patients with benign anorectal disease. American journal of surgery, 1994, Volume: 167, Issue:4 Topics: Anesthesia, Spinal; Anus Diseases; Bupivacaine; Humans; Postoperative Complications; Rectal Diseases	1994
An audit of extradural infusion analgesia in children using bupivacaine and diamorphine. Anaesthesia, 1993, Volume: 48, Issue:8 Topics: Adolescent; Analgesia, Epidural; Bupivacaine; Child; Child, Preschool; Heroin; Humans; Infant; Infan	1993
Complications of super-selective subarachnoid anesthesia (SSA) with hyperbaric bupivacaine: experiences with 355 patients in general and orthopaedic surgery. Panminerva medica, 1997, Volume: 39, Issue:1 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anesthesia, Spinal; Back Pain; Bupivacaine; Female; Head	1997
Ambulatory laparoscopic fundoplication. Surgical endoscopy, 1997, Volume: 11, Issue:12 Topics: Adult; Aged; Ambulatory Surgical Procedures; Analgesics, Non-Narcotic; Analgesics, Opioid; Anestheti	1997
Postoperative urinary retention in a dog following morphine with bupivacaine epidural analgesia. The Canadian veterinary journal = La revue veterinaire canadienne, 1998, Volume: 39, Issue:10 Topics: Analgesia, Epidural; Analgesics, Opioid; Anesthetics, Local; Animals; Bupivacaine; Dogs; Male; Morph	1998
Epidural analgesia in children with cerebral palsy. Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1998, Volume: 45, Issue:12 Topics: Analgesia, Epidural; Analgesics, Opioid; Anesthetics, Local; Bupivacaine; Cerebral Palsy; Child; Con	1998
Elimination of urinary retention following inguinal herniorrhaphy. The American surgeon, 1991, Volume: 57, Issue:8 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anesthesia, General; Anesthesia, Local; Anesthesia, Spin	1991
Epidural anesthesia for lumbar spine surgery. Journal of spinal disorders, 1988, Volume: 1, Issue:2 Topics: Anesthesia, Epidural; Anesthesia, General; Bupivacaine; Female; Follow-Up Studies; Hemorrhage; Human	1988

bupivacaine and Urinary Retention