bupivacaine and Spinal Stenosis studies

Bupivacaine: A widely used local anesthetic agent.
1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide : A piperidinecarboxamide obtained by formal condensation of the carboxy group of N-butylpipecolic acid with the amino group of 2,6-dimethylaniline.
bupivacaine : A racemate composed of equimolar amounts of dextrobupivacaine and levobupivacaine. Used (in the form of its hydrochloride hydrate) as a local anaesthetic.

Research Excerpts

Excerpt	Relevance	Reference
"We report a case of persistent dysesthesia lasting over a year in a patient after uneventful spinal anes- thesia with bupivacaine."	7.85	[A Case of Persistent Dysesthesia after Uneventful Spinal Anesthesia with Bupivacaine]. ( Harada, T; Okada, R; Sakai, M, 2017)
"We report a case of persistent dysesthesia lasting over a year in a patient after uneventful spinal anes- thesia with bupivacaine."	3.85	[A Case of Persistent Dysesthesia after Uneventful Spinal Anesthesia with Bupivacaine]. ( Harada, T; Okada, R; Sakai, M, 2017)
", periradicular injection of bupivacaine and triamcinolone) for lumbar monoradiculopathy in patients with a mild neurological deficit."	3.71	Therapeutic efficacy of selective nerve root blocks in the treatment of lumbar radicular leg pain. ( Boos, N; Narozny, M; Zanetti, M, 2001)
"1 mg buprenorphine performed under general anaesthesia for relieving wound pain after posterior interbody fusion and laminotomy for spinal stenosis."	3.69	Pre-incisional caudal epidural blockade and the relief of pain after lumbar spine operations. ( Abe, K; Kakiuchi, M, 1997)
"The lumbar spinal stenosis is a radiological description of a pathology that can present clinically by a neurogenic intermittent claudication; its diagnosis is mainly clinical."	2.48	[Lumbar spinal stenosis: clinical course, pathophysiology and treatment]. ( Chevallier-Ruggeri, P; Faundez, A; Genevay, S, 2012)

Research

Studies (20)

Authors

Clinical Trials (6)

Trial Overview

Trial Outcomes

Amount Achieved on Incentive Spirometer

Timeframe	Studies, this research(%)	All Research%
pre-1990	1 (5.00)	18.7374
1990's	2 (10.00)	18.2507
2000's	6 (30.00)	29.6817
2010's	8 (40.00)	24.3611
2020's	3 (15.00)	2.80

Authors	Studies
Sanghvi, C	1
Su, T	1
Yaksh, TL	1
Copenhaver, DJ	1
Klineberg, EO	1
Jung, MJ	1
Hofmann, UK	1
Keller, RL	1
von Bernstorff, M	1
Walter, C	1
Mittag, F	1
Shamov, T	1
Al-Hashel, JY	1
Rоusseff, RT	1
Ueshima, H	3
Otake, H	3
Sakai, M	1
Okada, R	1
Harada, T	1
Tagowski, M	1
Lewandowski, Z	1
Hodler, J	1
Spiegel, T	1
Goerres, GW	1
Kolcun, JPG	1
Brusko, GD	1
Basil, GW	1
Epstein, R	1
Wang, MY	1
Gündüz, OH	1
Akhlaque, U	1
Sencan, S	1
Celenlioglu, AE	1
Seker, A	1
Khan, MU	1
Hussain, SZ	1
Tafazal, S	1
Ng, L	1
Chaudhary, N	1
Sell, P	1
Genevay, S	1
Chevallier-Ruggeri, P	1
Faundez, A	1
McAllister, RK	1
McDavid, AJ	1
Meyer, TA	1
Bittenbinder, TM	1
Abanco, J	1
Ros, E	1
Llorens, J	1
Fores, J	1
Kakiuchi, M	1
Abe, K	1
Papagelopoulos, PJ	1
Petrou, HG	1
Triantafyllidis, PG	1
Vlamis, JA	1
Psomas-Pasalis, M	1
Korres, DS	1
Stamos, KG	1
Narozny, M	1
Zanetti, M	1
Boos, N	1
Dunbar, SA	1
Manikantan, P	1
Philip, J	1
Hoogmartens, M	1
Morelle, P	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Effectiveness of Ultrasound-guided Erector Spinae Plane Block for Postoperative Pain Control in Hip Replacement Surgeries[NCT04003909]		30 participants (Actual)	Interventional	2019-07-05	Completed
Randomized Clinical Trial of Erector Spinae Plane (ESP) Versus Paravertebral Nerve (PVB) Blockade for Video Assisted Thoracoscopic Surgery (VATS)[NCT03758261]	Phase 4	35 participants (Actual)	Interventional	2019-03-11	Completed
The Efficacy of Ultrasound-Guided Quadratus Lumborum Block for Pain Management Following Lumbar Spinal Surgery[NCT04981301]		60 participants (Actual)	Interventional	2021-08-02	Completed
Comparison of the Effectiveness of Ultrasound-Guided Quadratus Lumborum 2 Block and Classic Thoracolumbar Interfacial Plane Block in the Management of Postoperative Analgesia After Lumbar Spinal Surgery[NCT05421585]		57 participants (Actual)	Interventional	2022-08-15	Completed
A Randomized, Double Blind, Placebo Controlled Evaluation Trial of the Benefit in Quadratus Lumborum Block as a Postoperative Analgesic Technique for a Lumbar Spine Decompression and Fusion Surgery[NCT04447950]		100 participants (Anticipated)	Interventional	2020-06-30	Not yet recruiting
Determination Of The Relationship Between Local Anesthetic Volume And Its Dispersion In Ultrasound Guided Quadratus Lumborum Block In Cadavers[NCT03545295]		20 participants (Anticipated)	Interventional	2018-08-01	Not yet recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Amount achieved on incentive spirometer device (mL). Higher level indicates better respiratory effort (NCT03758261)
Timeframe: 1 day post catheter removal

Averaged Total of Narcotic Usage

Intervention	milliliter (mL) (Mean)
Erector Spinae Nerve Block	1221.15
Paravertebral Nerve Block	1187.50

Averaged total Narcotic consumption measured in Oral Morphine Equivalence (OME) (NCT03758261)
Timeframe: 0-120 hours post-operative

Length of Hospital Stay

Intervention	Average of OME (Mean)
Erector Spinae Nerve Block	187.36
Paravertebral Nerve Block	164.7

Length of hospital stay post-surgery (NCT03758261)
Timeframe: Up to 2 weeks on average

Patient Reported Pain Scores

Intervention	hours (Mean)
Erector Spinae Nerve Block	101.96
Paravertebral Nerve Block	96.30

Visual analog scale. Scale is from 0 to 10 numerical pain rating scale. 0 indicates no pain. 10 indicates maximum level of pain. Higher scores indicate worse pain level. Pain score will be a single number from 0 to 10. (NCT03758261)
Timeframe: 1 day post catheter removal

Report of Adverse Events From Catheter Placement

Intervention	score on a scale (Mean)
Erector Spinae Nerve Block	5.98
Paravertebral Nerve Block	5.16

Participant count for patients who experienced adverse events with nerve block catheter placement which includes pneumothorax, infections, bleeding, local anesthetic toxicity. (NCT03758261)
Timeframe: 1 day post catheter removal

Time Catheter Remains Inserted in Body

Total Opioid Consumption

Intervention	Participants (Count of Participants)
Erector Spinae Nerve Block	0
Paravertebral Nerve Block	0

Intervention	hours (Mean)
Erector Spinae Nerve Block	21.99
Paravertebral Nerve Block	21.94

Morphine equivalents (total OME) (NCT03758261)
Timeframe: 1 day post catheter removal

Article	Year
Corticosteroids in peri-radicular infiltration for radicular pain: a randomised double blind controlled trial. One year results and subgroup analysis. European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2009, Volume: 18, Issue:8 Topics: Adrenal Cortex Hormones; Anesthetics, Local; Anti-Inflammatory Agents; Bupivacaine; Disability Evalu	2009
Treatment of lumbosacral radicular pain with epidural steroid injections. Orthopedics, 2001, Volume: 24, Issue:2 Topics: Adult; Aged; Aged, 80 and over; Anesthetics, Local; Anti-Inflammatory Agents; Bupivacaine; Contraind	2001
Epidural infusion pressure in degenerative spinal disease before and after epidural steroid therapy. Anesthesia and analgesia, 2002, Volume: 94, Issue:2 Topics: Adult; Anesthetics, Local; Anti-Inflammatory Agents; Bupivacaine; Epidural Space; Glucocorticoids; H	2002

Article	Year
Severe altered mentation due to cervicothoracic intrathecal pump after correction of cervical stenosis: a case report. Regional anesthesia and pain medicine, 2021, Volume: 46, Issue:12 Topics: Analgesics, Opioid; Bupivacaine; Cervical Vertebrae; Constriction, Pathologic; Humans; Injections, S	2021
Predictability of the effects of epidural injection in lumbar spinal stenosis by assessment of lumbar MRI scans. Journal of back and musculoskeletal rehabilitation, 2020, Volume: 33, Issue:4 Topics: Adult; Aged; Anti-Inflammatory Agents; Bupivacaine; Female; Glucocorticoids; Humans; Injections, Epi	2020
Fluoroscopic Epidural Steroid Injection: Pain Relief in Discogenic Sciatica Versus Lumbar Spinal Stenosis. A Study on Middle Eastern Patients. Acta medica (Hradec Kralove), 2020, Volume: 63, Issue:2 Topics: Adult; Aged; Analgesia, Epidural; Anesthetics, Local; Anti-Inflammatory Agents; Bupivacaine; Case-Co	2020
RETRACTED: Clinical experiences of ultrasound-guided erector spinae plane block for thoracic vertebra surgery. Journal of clinical anesthesia, 2017, Volume: 38 Topics: Aged; Aged, 80 and over; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Ane	2017
RETRACTED: Clinical experiences of ultrasound-guided erector spinae plane block for thoracic vertebra surgery. Journal of clinical anesthesia, 2017, Volume: 38 Topics: Aged; Aged, 80 and over; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Ane	2017
RETRACTED: Clinical experiences of ultrasound-guided erector spinae plane block for thoracic vertebra surgery. Journal of clinical anesthesia, 2017, Volume: 38 Topics: Aged; Aged, 80 and over; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Ane	2017
RETRACTED: Clinical experiences of ultrasound-guided erector spinae plane block for thoracic vertebra surgery. Journal of clinical anesthesia, 2017, Volume: 38 Topics: Aged; Aged, 80 and over; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Ane	2017
[A Case of Persistent Dysesthesia after Uneventful Spinal Anesthesia with Bupivacaine]. Masui. The Japanese journal of anesthesiology, 2017, Volume: 66, Issue:1 Topics: Aged; Anesthesia, Spinal; Bupivacaine; Female; Humans; Magnetic Resonance Imaging; Paresthesia; Spin	2017
Pain reduction after lumbar epidural injections using particulate versus non-particulate steroids: intensity of the baseline pain matters. European radiology, 2019, Volume: 29, Issue:7 Topics: Adult; Aged; Back Pain; Bupivacaine; Dexamethasone; Female; Glucocorticoids; Humans; Injections, Epi	2019
Endoscopic transforaminal lumbar interbody fusion without general anesthesia: operative and clinical outcomes in 100 consecutive patients with a minimum 1-year follow-up. Neurosurgical focus, 2019, 04-01, Volume: 46, Issue:4 Topics: Adult; Aged; Aged, 80 and over; Anesthesia; Anesthesia, Local; Anesthetics, Local; Bupivacaine; Disk	2019
Contralateral lumbar radicular pain shortly after a transforaminal epidural steroid injection: an unusual sequel. American journal of physical medicine & rehabilitation, 2014, Volume: 93, Issue:9 Topics: Adult; Anesthetics, Local; Bupivacaine; Fluoroscopy; Humans; Injections, Epidural; Intervertebral Di	2014
RETRACTED: Clinical experience of anterior quadratus lumborum block after lumber surgery. Journal of clinical anesthesia, 2017, Volume: 37 Topics: Abdominal Muscles; Analgesia; Anesthesia, General; Anesthetics, Local; Bupivacaine; Femoral Fracture	2017
RETRACTED: Clinical experience of anterior quadratus lumborum block after lumber surgery. Journal of clinical anesthesia, 2017, Volume: 37 Topics: Abdominal Muscles; Analgesia; Anesthesia, General; Anesthetics, Local; Bupivacaine; Femoral Fracture	2017
RETRACTED: Clinical experience of anterior quadratus lumborum block after lumber surgery. Journal of clinical anesthesia, 2017, Volume: 37 Topics: Abdominal Muscles; Analgesia; Anesthesia, General; Anesthetics, Local; Bupivacaine; Femoral Fracture	2017
RETRACTED: Clinical experience of anterior quadratus lumborum block after lumber surgery. Journal of clinical anesthesia, 2017, Volume: 37 Topics: Abdominal Muscles; Analgesia; Anesthesia, General; Anesthetics, Local; Bupivacaine; Femoral Fracture	2017
RETRACTED: Clinical experience of anterior quadratus lumborum block after lumber surgery. Journal of clinical anesthesia, 2017, Volume: 37 Topics: Abdominal Muscles; Analgesia; Anesthesia, General; Anesthetics, Local; Bupivacaine; Femoral Fracture	2017
RETRACTED: Clinical experience of anterior quadratus lumborum block after lumber surgery. Journal of clinical anesthesia, 2017, Volume: 37 Topics: Abdominal Muscles; Analgesia; Anesthesia, General; Anesthetics, Local; Bupivacaine; Femoral Fracture	2017
RETRACTED: Clinical experience of anterior quadratus lumborum block after lumber surgery. Journal of clinical anesthesia, 2017, Volume: 37 Topics: Abdominal Muscles; Analgesia; Anesthesia, General; Anesthetics, Local; Bupivacaine; Femoral Fracture	2017
RETRACTED: Clinical experience of anterior quadratus lumborum block after lumber surgery. Journal of clinical anesthesia, 2017, Volume: 37 Topics: Abdominal Muscles; Analgesia; Anesthesia, General; Anesthetics, Local; Bupivacaine; Femoral Fracture	2017
RETRACTED: Clinical experience of anterior quadratus lumborum block after lumber surgery. Journal of clinical anesthesia, 2017, Volume: 37 Topics: Abdominal Muscles; Analgesia; Anesthesia, General; Anesthetics, Local; Bupivacaine; Femoral Fracture	2017
RETRACTED: Lower limb amputations performed with anterior quadratus lumborum block and sciatic nerve block. Journal of clinical anesthesia, 2017, Volume: 37 Topics: Abdominal Muscles; Aged; Aged, 80 and over; Amputation, Surgical; Anesthetics, Local; Anticoagulants	2017
Role of psoas compartment and caudal epidural steroid injection in spinal stenosis patients associated with low back pain and lower limb radiculopathy. JPMA. The Journal of the Pakistan Medical Association, 2008, Volume: 58, Issue:9 Topics: Activities of Daily Living; Adrenal Cortex Hormones; Adult; Aged; Aged, 80 and over; Anti-Inflammato	2008
Recurrent persistent hiccups after epidural steroid injection and analgesia with bupivacaine. Anesthesia and analgesia, 2005, Volume: 100, Issue:6 Topics: Aged; Analgesia, Epidural; Anesthetics, Local; Arthroplasty, Replacement, Knee; Bupivacaine; Chronic	2005
[Epidural infiltrations in the treatment of lumbar radiculopathy. Apropos of 200 cases]. Revue de chirurgie orthopedique et reparatrice de l'appareil moteur, 1994, Volume: 80, Issue:8 Topics: Adolescent; Adult; Aged; Bupivacaine; Data Interpretation, Statistical; Female; Follow-Up Studies; H	1994
Pre-incisional caudal epidural blockade and the relief of pain after lumbar spine operations. International orthopaedics, 1997, Volume: 21, Issue:1 Topics: Adult; Aged; Analgesics, Opioid; Anesthesia, Caudal; Anesthetics, Local; Bupivacaine; Buprenorphine;	1997
Therapeutic efficacy of selective nerve root blocks in the treatment of lumbar radicular leg pain. Swiss medical weekly, 2001, Feb-10, Volume: 131, Issue:5-6 Topics: Adult; Aged; Aged, 80 and over; Bupivacaine; Female; Humans; Injections; Intervertebral Disc Displac	2001
Epidural injection in the treatment of spinal stenosis. Acta orthopaedica Belgica, 1987, Volume: 53, Issue:3 Topics: Adult; Aged; Bupivacaine; Drug Therapy, Combination; Female; Glucuronidase; Humans; Hydrocortisone;	1987

bupivacaine and Spinal Stenosis