Page last updated: 2024-10-24

bupivacaine and Spinal Cord Neoplasms

bupivacaine has been researched along with Spinal Cord Neoplasms in 5 studies

Bupivacaine: A widely used local anesthetic agent.
1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide : A piperidinecarboxamide obtained by formal condensation of the carboxy group of N-butylpipecolic acid with the amino group of 2,6-dimethylaniline.
bupivacaine : A racemate composed of equimolar amounts of dextrobupivacaine and levobupivacaine. Used (in the form of its hydrochloride hydrate) as a local anaesthetic.

Spinal Cord Neoplasms: Benign and malignant neoplasms which occur within the substance of the spinal cord (intramedullary neoplasms) or in the space between the dura and spinal cord (intradural extramedullary neoplasms). The majority of intramedullary spinal tumors are primary CNS neoplasms including ASTROCYTOMA; EPENDYMOMA; and LIPOMA. Intramedullary neoplasms are often associated with SYRINGOMYELIA. The most frequent histologic types of intradural-extramedullary tumors are MENINGIOMA and NEUROFIBROMA.

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (40.00)18.2507
2000's2 (40.00)29.6817
2010's1 (20.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Ueshima, H1
Otake, H1
Holmfred, A1
Wadhwa, RK1
Shaya, MR1
Nanda, A1
Lema, MJ1
Shady, JA1
Zoll, JG1
West, CR1
Berde, CB1
Sethna, NF1
Conrad, LS1
Hershenson, MB1
Shillito, J1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Effectiveness of Ultrasound-guided Erector Spinae Plane Block for Postoperative Pain Control in Hip Replacement Surgeries[NCT04003909]30 participants (Actual)Interventional2019-07-05Completed
Randomized Clinical Trial of Erector Spinae Plane (ESP) Versus Paravertebral Nerve (PVB) Blockade for Video Assisted Thoracoscopic Surgery (VATS)[NCT03758261]Phase 435 participants (Actual)Interventional2019-03-11Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Amount Achieved on Incentive Spirometer

Amount achieved on incentive spirometer device (mL). Higher level indicates better respiratory effort (NCT03758261)
Timeframe: 1 day post catheter removal

Interventionmilliliter (mL) (Mean)
Erector Spinae Nerve Block1221.15
Paravertebral Nerve Block1187.50

Averaged Total of Narcotic Usage

Averaged total Narcotic consumption measured in Oral Morphine Equivalence (OME) (NCT03758261)
Timeframe: 0-120 hours post-operative

InterventionAverage of OME (Mean)
Erector Spinae Nerve Block187.36
Paravertebral Nerve Block164.7

Length of Hospital Stay

Length of hospital stay post-surgery (NCT03758261)
Timeframe: Up to 2 weeks on average

Interventionhours (Mean)
Erector Spinae Nerve Block101.96
Paravertebral Nerve Block96.30

Patient Reported Pain Scores

Visual analog scale. Scale is from 0 to 10 numerical pain rating scale. 0 indicates no pain. 10 indicates maximum level of pain. Higher scores indicate worse pain level. Pain score will be a single number from 0 to 10. (NCT03758261)
Timeframe: 1 day post catheter removal

Interventionscore on a scale (Mean)
Erector Spinae Nerve Block5.98
Paravertebral Nerve Block5.16

Report of Adverse Events From Catheter Placement

Participant count for patients who experienced adverse events with nerve block catheter placement which includes pneumothorax, infections, bleeding, local anesthetic toxicity. (NCT03758261)
Timeframe: 1 day post catheter removal

InterventionParticipants (Count of Participants)
Erector Spinae Nerve Block0
Paravertebral Nerve Block0

Time Catheter Remains Inserted in Body

How long catheter remains providing pain relief (NCT03758261)
Timeframe: 6 days

Interventionhours (Mean)
Erector Spinae Nerve Block21.99
Paravertebral Nerve Block21.94

Total Opioid Consumption

Morphine equivalents (total OME) (NCT03758261)
Timeframe: 1 day post catheter removal

Interventionmg morphine equivalent (MME) (Mean)
Erector Spinae Nerve Block187.36
Paravertebral Nerve Block164.70

Other Studies

5 other studies available for bupivacaine and Spinal Cord Neoplasms

ArticleYear
RETRACTED: Clinical experiences of ultrasound-guided erector spinae plane block for thoracic vertebra surgery.
    Journal of clinical anesthesia, 2017, Volume: 38

    Topics: Aged; Aged, 80 and over; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Ane

2017
RETRACTED: Clinical experiences of ultrasound-guided erector spinae plane block for thoracic vertebra surgery.
    Journal of clinical anesthesia, 2017, Volume: 38

    Topics: Aged; Aged, 80 and over; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Ane

2017
RETRACTED: Clinical experiences of ultrasound-guided erector spinae plane block for thoracic vertebra surgery.
    Journal of clinical anesthesia, 2017, Volume: 38

    Topics: Aged; Aged, 80 and over; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Ane

2017
RETRACTED: Clinical experiences of ultrasound-guided erector spinae plane block for thoracic vertebra surgery.
    Journal of clinical anesthesia, 2017, Volume: 38

    Topics: Aged; Aged, 80 and over; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Ane

2017
Failed intrathecal analgesia following severe, terminal cancer pain.
    Acta anaesthesiologica Scandinavica, 2004, Volume: 48, Issue:6

    Topics: Amines; Analgesics; Anesthetics, Local; Back Pain; Bupivacaine; Catheterization; Clonidine; Cyclohex

2004
Spinal cord compression in a patient with a pain pump for failed back syndrome: a chalk-like precipitate mimicking a spinal cord neoplasm: case report.
    Neurosurgery, 2006, Volume: 58, Issue:2

    Topics: Aged; Back Pain; Bupivacaine; Calcium Carbonate; Diagnosis, Differential; Female; Humans; Infusion P

2006
Management of intractable back pain from caudal ependymoma with spinal methylprednisolone, bupivacaine and morphine.
    Pain, 1992, Volume: 48, Issue:2

    Topics: Adult; Bupivacaine; Cauda Equina; Drug Combinations; Ependymoma; Female; Humans; Injections, Spinal;

1992
Subarachnoid bupivacaine analgesia for seven months for a patient with a spinal cord tumor.
    Anesthesiology, 1990, Volume: 72, Issue:6

    Topics: Adult; Analgesia; Astrocytoma; Bupivacaine; Female; Humans; Pain, Intractable; Spinal Cord Neoplasms

1990