Page last updated: 2024-10-24

bupivacaine and Sleep Apnea Syndromes

bupivacaine has been researched along with Sleep Apnea Syndromes in 5 studies

Bupivacaine: A widely used local anesthetic agent.
1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide : A piperidinecarboxamide obtained by formal condensation of the carboxy group of N-butylpipecolic acid with the amino group of 2,6-dimethylaniline.
bupivacaine : A racemate composed of equimolar amounts of dextrobupivacaine and levobupivacaine. Used (in the form of its hydrochloride hydrate) as a local anaesthetic.

Sleep Apnea Syndromes: Disorders characterized by multiple cessations of respirations during sleep that induce partial arousals and interfere with the maintenance of sleep. Sleep apnea syndromes are divided into central (see SLEEP APNEA, CENTRAL), obstructive (see SLEEP APNEA, OBSTRUCTIVE), and mixed central-obstructive types.

Research

Studies (5)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	3 (60.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	1 (20.00)	24.3611
2020's	1 (20.00)	2.80

Authors

Authors	Studies
Albrecht, E	1
Bayon, V	1
Hirotsu, C	1
Al Ja'bari, A	1
Heinzer, R	1
Moss, JR	1
Cofer, S	1
Hersey, S	1
Goudy, S	1
Werkhaven, J	1
Swanson, E	1
Mantle, C	1
Stowell, N	1
Byrne, D	1
Wang, L	1
Labadie, R	1
Deegan, PC	1
Mulloy, E	1
McNicholas, WT	1
Ostermeier, AM	1
Roizen, MF	1
Hautkappe, M	1
Klock, PA	1
Klafta, JM	1
Clyburn, PA	1
Rosen, M	1
Vickers, MD	1

Clinical Trials (4)

Trial Overview

Trial	Phase	Enrollment	Study Type	Start Date	Status
Impact of Intrathecal Morphine on Sleep Apnea Syndrome After Hip Arthroplasty Performed Under Spinal Anaesthesia[NCT02566226]	Phase 4	60 participants (Actual)	Interventional	2015-11-30	Completed
Pediatric Tonsillectomy Pain Reduction Study, a Randomized, Placebo Controlled, Double-Blind Clinical Trial Using Clonidine and Local Anesthetics[NCT00678379]	Phase 3	120 participants (Actual)	Interventional	2008-04-30	Completed
Postoperative Management of Obstructive Sleep Apnea With CPAP vs. an Autoadjusting CPAP Device: a Randomized Controlled Single Center Trial[NCT00588848]		11 participants (Actual)	Interventional	2008-01-31	Terminated (stopped due to Difficulty with enrollment)
The Effect of Acute Intravenous Morphine Administration on Sleep Disordered Breathing (SDB) in Patients With Moderate Obstructive Sleep Apnoea (OSA): A Paired Design Trial[NCT03127800]	Phase 3	6 participants (Actual)	Interventional	2016-05-20	Terminated (stopped due to Difficulties with recruitment)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Median Number of Pain Medication Doses

The median number of intravenous fentanyl doses administered in the PACU due to pain (NCT00678379)
Timeframe: in recovery room

Intervention	number of doses (Median)
Normal Saline	3.0
Lidocaine (1%) + Bupivacaine 0.5%	3
Lidocaine 1% + Bupivacaine o.5% + Clondine 25mcg	3

Total Number of Post-operative Doses of Analgesics.

The total number of intravenous fentanyl doses given PACU which will be compared between the three randomized groups (arms) (NCT00678379)
Timeframe: Post-operative thru day 7

Intervention	number of doses (Median)
Normal Saline	12
Lidocaine (1%) + Bupivacaine 0.5%	12
Lidocaine 1% + Bupivacaine o.5% + Clondine 25mcg	14

Total Time Until Discharge From Hospital.

(NCT00678379)
Timeframe: Day of Surgery

Intervention	minutes (Median)
Normal Saline	122
Lidocaine (1%) + Bupivacaine 0.5%	111
Lidocaine 1% + Bupivacaine o.5% + Clondine 25mcg	120

Mean Visual Analog Scale Pain Number.

Visual analog pain scale range is 0-10 with 0=no pain and 10 = worst pain ever (NCT00678379)
Timeframe: in recovery room; post-operative days 1,3,5 & 7

Intervention	pain score (Mean)
	In recovery room	day 1	day 3	day 5	day 7
Lidocaine (1%) + Bupivacaine 0.5%	3	4	2.5	2	2
Lidocaine 1% + Bupivacaine o.5% + Clondine 25mcg	3	5	3	3	2
Normal Saline	3	3	3	3	2.5

Number and Percent of Participants Able to Tolerate a Regular Diet

The number and percent of patients whose post-operative diet has to a regular diet on post-operative days 1, 3, 5 & 7 (NCT00678379)
Timeframe: post-operative days 1,3,5 & 7.

Intervention	Participants (Count of Participants)
	post-op day 1	post-op day 3	post op day 5	post op day 7
Lidocaine (1%) + Bupivacaine 0.5%	4	8	18	26
Lidocaine 1% + Bupivacaine o.5% + Clondine 25mcg	1	12	14	22
Normal Saline	7	18	21	24

Number and Percent of Participants Able to Tolerate Only a Soft Diet

The number and percent of patients whose post-operative diet has only advanced to a soft diet on post-operative days 1, 3, 5 & 7 (NCT00678379)
Timeframe: post-operative days 1,3,5 & 7.

Intervention	Participants (Count of Participants)
	post-op day 1	post-op day 3	post op day 5	post op day 7
Lidocaine (1%) + Bupivacaine 0.5%	22	26	17	10
Lidocaine 1% + Bupivacaine o.5% + Clondine 25mcg	26	18	18	14
Normal Saline	26	18	13	13

Number and Percent of Participants Able to Tolerate Only Liquids

The number and percent of patients whose post-operative diet has advanced to liquids only on post-op days 1, 3, 5 & 7 (NCT00678379)
Timeframe: post-operative days 1,3,5 & 7.

Intervention	Participants (Count of Participants)
	post-op day 1	post-op day 3	post op day 5	post op day 7
Lidocaine (1%) + Bupivacaine 0.5%	33	13	10	11
Lidocaine 1% + Bupivacaine o.5% + Clondine 25mcg	30	23	19	10
Normal Saline	16	8	13	6

Apnea-Hypopnea Index (AHI)

Events are defined as apneas and hypopneas. AHI values are typically categorized as 5-14.9 events/hr = mild; 15-29.9 events/hr = moderate; and >= 30 events/hr = severe (NCT00588848)
Timeframe: On postoperative night number 1 from 2200 to 0600. Study participation will end within 72 hours of admission.

Intervention	events per hour (Mean)
AUTOCPAP	2.1
CPAP	1.2

Cardiopulmonary Complications

Predefined cardiopulmonary complications: Myocardial Infarction, Arrhythmia, new onset Heart Failure, Stroke (NCT00588848)
Timeframe: 72 hours

Intervention	Participants (Count of Participants)
Autoadjusting CPAP (VPAP Auto)	0
CPAP Arm (Usual Care)	0

Sleep Related Hypoxemia

(NCT00588848)
Timeframe: On postoperative night number 1 from 2200 to 0600. Study participation will end within 72 hours of admission.

Intervention	Percentage of time < 90% saturation (Mean)
AUTOCPAP	10.5
CPAP	7.1

Reviews

1 review available for bupivacaine and Sleep Apnea Syndromes

Article	Year
Three sudden postoperative respiratory arrests associated with epidural opioids in patients with sleep apnea. Anesthesia and analgesia, 1997, Volume: 85, Issue:2 Topics: Adult; Aged; Analgesia, Epidural; Analgesics, Opioid; Apnea; Blood Pressure; Bupivacaine; Female; Fe	1997
Three sudden postoperative respiratory arrests associated with epidural opioids in patients with sleep apnea. Anesthesia and analgesia, 1997, Volume: 85, Issue:2 Topics: Adult; Aged; Analgesia, Epidural; Analgesics, Opioid; Apnea; Blood Pressure; Bupivacaine; Female; Fe	1997
Three sudden postoperative respiratory arrests associated with epidural opioids in patients with sleep apnea. Anesthesia and analgesia, 1997, Volume: 85, Issue:2 Topics: Adult; Aged; Analgesia, Epidural; Analgesics, Opioid; Apnea; Blood Pressure; Bupivacaine; Female; Fe	1997
Three sudden postoperative respiratory arrests associated with epidural opioids in patients with sleep apnea. Anesthesia and analgesia, 1997, Volume: 85, Issue:2 Topics: Adult; Aged; Analgesia, Epidural; Analgesics, Opioid; Apnea; Blood Pressure; Bupivacaine; Female; Fe	1997

Trials

4 trials available for bupivacaine and Sleep Apnea Syndromes

Article	Year
Intrathecal morphine and sleep apnoea severity in patients undergoing hip arthroplasty: a randomised, controlled, triple-blinded trial. British journal of anaesthesia, 2020, Volume: 125, Issue:5 Topics: Aged; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthesia, Spinal; Anesthetics, Local; Art	2020
Comparison of clonidine, local anesthetics, and placebo for pain reduction in pediatric tonsillectomy. Archives of otolaryngology--head & neck surgery, 2011, Volume: 137, Issue:6 Topics: Adenoids; Adolescent; Age Factors; Analgesics; Anesthetics, Local; Bupivacaine; Child; Child, Presch	2011
Topical oropharyngeal anesthesia in patients with obstructive sleep apnea. American journal of respiratory and critical care medicine, 1995, Volume: 151, Issue:4 Topics: Bupivacaine; Humans; Lidocaine; Male; Middle Aged; Respiration; Respiratory Function Tests; Sleep Ap	1995
Comparison of the respiratory effects of i.v. infusions of morphine and regional analgesia by extradural block. British journal of anaesthesia, 1990, Volume: 64, Issue:4 Topics: Abdomen; Adult; Aged; Analgesia, Epidural; Arrhythmias, Cardiac; Bupivacaine; Female; Humans; Infusi	1990