bupivacaine and Seizures studies

Bupivacaine: A widely used local anesthetic agent.
1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide : A piperidinecarboxamide obtained by formal condensation of the carboxy group of N-butylpipecolic acid with the amino group of 2,6-dimethylaniline.
bupivacaine : A racemate composed of equimolar amounts of dextrobupivacaine and levobupivacaine. Used (in the form of its hydrochloride hydrate) as a local anaesthetic.

Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.

Research Excerpts

Excerpt	Relevance	Reference
"We compared the neurotoxic profile of racemic bupivacaine and levobupivacaine in: (i) a mouse model of N-methyl-D-aspartate (NMDA)-induced seizures and (ii) in an in vitro model of excitotoxic cell death."	7.73	Comparative effects of levobupivacaine and racemic bupivacaine on excitotoxic neuronal death in culture and N-methyl-D-aspartate-induced seizures in mice. ( Bruno, V; Marganella, C; Matrisciano, F; Melchiorri, D; Nicoletti, F; Reale, C, 2005)
" The purpose of this study was to investigate the effects of sevoflurane and isoflurane on bupivacaine-induced arrhythmias and seizures in rats."	7.69	Sevoflurane is equivalent to isoflurane for attenuating bupivacaine-induced arrhythmias and seizures in rats. ( Fukuda, H; Hirabayashi, Y; Mitsuhata, H; Saitoh, K; Shimizu, R, 1996)
"Toxic systemic reactions to bupivacaine usually involve a number of factors, including hypoxia and acidosis."	7.68	Severe hypoxia enhances central nervous system and cardiovascular toxicity of bupivacaine in lightly anesthetized pigs. ( Badgwell, JM; Bessire, A; Dryden, CF; Heavner, JE; Huemer, G; Sanghani, V, 1992)
" In contrast, ovine pregnancy does not enhance the toxicity of mepivacaine, a drug with properties similar to lidocaine."	7.68	Pregnancy does not alter lidocaine toxicity. ( Arthur, GR; Covino, BG; Finster, M; Morishima, HO, 1990)
"Intraoperative seizures were more common among the neurolept patients (7 vs 0, P = 0."	6.68	Propofol sedation during awake craniotomy for seizures: patient-controlled administration versus neurolept analgesia. ( Craen, RA; Eliasziw, M; Gelb, AW; Girvin, JP; Herrick, IA; Kirkby, J; Kubu, CS; Miller, LA; Parrent, AG, 1997)
"Bupivacaine is a commonly used local anesthetic in dental, ophthalmologic, and simple surgical procedures."	5.30	Bupivacaine-induced seizures and ventricular fibrillation in a 13-year-old girl undergoing wound debridement. ( Newman, RD; Yan, AC, 1998)
"until the animals died."	5.29	Comparison of propofol with thiopentone for treatment of bupivacaine-induced seizures in rats. ( Arthur, J; Heavner, JE; McDaniel, K; Rosenberg, PH; Tyman-Szram, B; Zou, J, 1993)
"Seizures have been reported with lidocaine at its lowest effective dose (1."	4.85	Adverse events associated with intravenous regional anesthesia (Bier block): a systematic review of complications. ( Guay, J, 2009)
" Next, during continuous intravenous infusion of equipotent doses of bupivacaine, dextromethorphan, and dextrorphan (n = 8 in each group), we observed the time to seizure, apnea, and complete cardiac arrest."	3.77	Systemic dextromethorphan and dextrorphan are less toxic in rats than bupivacaine at equianesthetic doses. ( Chen, YC; Chen, YW; Hung, CH; Liu, TY; Wang, JJ, 2011)
"Accidental intravascular administration of bupivacaine during performance of a brachial block precipitated convulsions followed by asystole."	3.75	Recurrence of cardiotoxicity after lipid rescue from bupivacaine-induced cardiac arrest. ( Coetzee, AR; Levin, AI; Marwick, PC, 2009)
" Fatal cardiac arrhythmias occurred in, respectively, 3 of 11, 2 of 12, and 2 of 13 conscious sheep infused with bupivacaine, levobupivacaine, and ropivacaine; in 1 of 9 with prilocaine, electromechanical dissociation (followed by polymorphic ventricular tachycardia) caused death."	3.74	The effects of general anesthesia on the central nervous and cardiovascular system toxicity of local anesthetics. ( Copeland, SE; Gu, XQ; Ladd, LA; Mather, LE, 2008)
"We compared the neurotoxic profile of racemic bupivacaine and levobupivacaine in: (i) a mouse model of N-methyl-D-aspartate (NMDA)-induced seizures and (ii) in an in vitro model of excitotoxic cell death."	3.73	Comparative effects of levobupivacaine and racemic bupivacaine on excitotoxic neuronal death in culture and N-methyl-D-aspartate-induced seizures in mice. ( Bruno, V; Marganella, C; Matrisciano, F; Melchiorri, D; Nicoletti, F; Reale, C, 2005)
" This study was undertaken to determine whether pregnancy affects the systemic toxicity of levobupivacaine and to compare the systemic toxicity of levobupivacaine with that of bupivacaine and ropivacaine."	3.71	Systemic toxicity of levobupivacaine, bupivacaine, and ropivacaine during continuous intravenous infusion to nonpregnant and pregnant ewes. ( DeArmas, PI; Santos, AC, 2001)
" Arterial blood samples were obtained before infusion and at the onset of toxic manifestations, which appeared in the following sequence: convulsions, hypotension, apnea, and circulatory collapse."	3.69	Comparative systemic toxicity of ropivacaine and bupivacaine in nonpregnant and pregnant ewes. ( Arthur, GR; De Armas, P; Finster, M; Morishima, HO; Santos, AC; Wlody, D, 1995)
" The purpose of this study was to investigate the effects of sevoflurane and isoflurane on bupivacaine-induced arrhythmias and seizures in rats."	3.69	Sevoflurane is equivalent to isoflurane for attenuating bupivacaine-induced arrhythmias and seizures in rats. ( Fukuda, H; Hirabayashi, Y; Mitsuhata, H; Saitoh, K; Shimizu, R, 1996)
"Toxic systemic reactions to bupivacaine usually involve a number of factors, including hypoxia and acidosis."	3.68	Severe hypoxia enhances central nervous system and cardiovascular toxicity of bupivacaine in lightly anesthetized pigs. ( Badgwell, JM; Bessire, A; Dryden, CF; Heavner, JE; Huemer, G; Sanghani, V, 1992)
" Seizures were abolished by 10 mg/kg of intravenous thiamylal."	3.68	Treatment of acute systemic toxicity after the rapid intravenous injection of ropivacaine and bupivacaine in the conscious dog. ( Arthur, GR; Covino, BG; Doucette, AM; Feldman, HS; Hurley, R; Pitkanen, M, 1991)
" In contrast, ovine pregnancy does not enhance the toxicity of mepivacaine, a drug with properties similar to lidocaine."	3.68	Pregnancy does not alter lidocaine toxicity. ( Arthur, GR; Covino, BG; Finster, M; Morishima, HO, 1990)
"The influence of hyperkalemia on the central nervous system and cardiac toxicity of bupivacaine and lidocaine was studied in open-chested mechanically ventilated dogs."	3.67	The influence of serum potassium on the cerebral and cardiac toxicity of bupivacaine and lidocaine. ( Avery, P; Redon, D; Rusy, B; Schaenzer, G, 1984)
"Except for one patient, who had seizures after an accidental IV injection of ropivacaine, there were no major side effects."	2.69	Axillary brachial plexus block with ropivacaine 7.5 mg/ml. A comparative study with bupivacaine 5 mg/ml. ( Bergheim, R; Drøsdahl, S; Isaksen, B; Klaastad, O; Kvalsvik, O; Mowinckel, P; Raeder, JC; Selander, D; Strømskag, KE, 1999)
"Intraoperative seizures were more common among the neurolept patients (7 vs 0, P = 0."	2.68	Propofol sedation during awake craniotomy for seizures: patient-controlled administration versus neurolept analgesia. ( Craen, RA; Eliasziw, M; Gelb, AW; Girvin, JP; Herrick, IA; Kirkby, J; Kubu, CS; Miller, LA; Parrent, AG, 1997)
"Levobupivacaine (0."	1.43	Effectiveness of retigabine against levobupivacaine-induced central nervous system toxicity: a prospective, randomized animal study. ( Chen, Y; Cheng, Y; Duan, R; Li, H; Li, J; Yuan, J; Zhao, S, 2016)
"At the onset of convulsions, fetuses were delivered and maternal and fetal blood, as well as various tissue samples, were obtained."	1.33	Magnesium and bupivacaine-induced convulsions in awake pregnant rats. ( Cooper, TB; Morishima, HO; Okutomi, T; Zhang, Y, 2005)
"At the onset of convulsions, plasma concentrations of both total (B = 4."	1.32	The P-glycoprotein inhibitor quinidine decreases the threshold for bupivacaine-induced, but not lidocaine-induced, convulsions in rats. ( Asada, A; Funao, T; Oda, Y; Tanaka, K, 2003)
"Neurotoxicity manifesting as convulsions is a recognised complication of the administration of local anaesthetic drugs as part of a regional anaesthetic technique."	1.31	Convulsions following axillary brachial plexus blockade with levobupivacaine. ( Pirotta, D; Sprigge, J, 2002)
"Bupivacaine seizure doses in 7-NI and L-NAME pretreated animals were similar to control but significantly different from each other."	1.31	Nitric oxide modulation affects the tissue distribution and toxicity of bupivacaine. ( Heavner, JE; Shi, B, 2000)
"All doses produced convulsions, QRS widening, and cardiac arrhythmias."	1.31	Tolerability of large-dose intravenous levobupivacaine in sheep. ( Chang, DH; Gelgor, L; Ladd, LA; Mather, LE; Wilson, KA, 2000)
"Pruritus was observed in 29% of patients and was more common in diplegia than quadriplegia (48% vs 12."	1.30	Epidural analgesia in children with cerebral palsy. ( Brenn, BR; Brislin, RP; Rose, JB, 1998)
"Doses were chosen to avoid convulsions (smaller dose 6."	1.30	Cardiovascular and central nervous system effects of intravenous levobupivacaine and bupivacaine in sheep. ( Huang, YF; Mather, LE; Pryor, ME; Veering, BT, 1998)
"Bupivacaine is a commonly used local anesthetic in dental, ophthalmologic, and simple surgical procedures."	1.30	Bupivacaine-induced seizures and ventricular fibrillation in a 13-year-old girl undergoing wound debridement. ( Newman, RD; Yan, AC, 1998)
"Bupivacaine was infused at a constant rate of 2 mg x kg(-1) x min(-1) while electrocardiogram, electroencephalogram, and invasive arterial pressure were continuously monitored."	1.30	A comparison of the effects of propofol and sevoflurane on the systemic toxicity of intravenous bupivacaine in rats. ( Kobayashi, T; Ohmura, S; Ohta, T; Yamamoto, K, 1999)
"The doses of bupivacaine inducing seizure and ventricular tachycardia were significantly higher for liposomal bupivacaine than for the two plain solutions."	1.29	Toxicity of bupivacaine encapsulated into liposomes and injected intravenously: comparison with plain solutions. ( Akodad, EM; Benameur, H; Boogaerts, J; Declercq, A; Dupont, JC; Lafont, N; Legros, FJ, 1993)
"until the animals died."	1.29	Comparison of propofol with thiopentone for treatment of bupivacaine-induced seizures in rats. ( Arthur, J; Heavner, JE; McDaniel, K; Rosenberg, PH; Tyman-Szram, B; Zou, J, 1993)
" In this rat model, desbutylbupivacaine was about half as toxic as bupivacaine judged by cardiac parameters, and clearly less toxic to the central nervous system than bupivacaine."	1.28	Acute cardiovascular and central nervous system toxicity of bupivacaine and desbutylbupivacaine in the rat. ( Heavner, JE; Rosenberg, PH, 1992)
"Bupivacaine was infused at a constant rate while the pigs' ECGs and EEGs were recorded."	1.28	Bupivacaine toxicity in young pigs is age-dependent and is affected by volatile anesthetics. ( Badgwell, JM; Heavner, JE; Kytta, J, 1990)
"No ventricular arrhythmias were observed in this group."	1.28	Comparative systemic toxicity of convulsant and supraconvulsant doses of intravenous ropivacaine, bupivacaine, and lidocaine in the conscious dog. ( Arthur, GR; Covino, BG; Feldman, HS, 1989)
"Bupivacaine infusion was continued until cardiovascular collapse."	1.28	Effect of epinephrine on central nervous system and cardiovascular system toxicity of bupivacaine in pigs. ( Bernards, CM; Brown, DL; Carpenter, RL; Kenter, ME; Rupp, SM; Thompson, GE, 1989)
" These results suggest that the CNS is the primary target organ for the toxic effects of both highly lipid-soluble and highly protein-bound local anesthetics (i."	1.27	Comparative CNS toxicity of lidocaine, etidocaine, bupivacaine, and tetracaine in awake dogs following rapid intravenous administration. ( Covino, BG; Feldman, HS; Giasi, R; Liu, PL; Patterson, MK, 1983)
" A variety of currently available local anesthetic compounds has been deemed safe for common usage in the field of anesthesia."	1.27	Local anesthetic toxicity: review and case studies. ( Kalil, AL, 1983)
"With flunitrazepam pretreatment, there were no deaths after lidocaine and only one after bupivacaine."	1.27	A comparison of flunitrazepam and diazepam in the prevention of local anesthetic-induced convulsions. ( Aronson, HB; Vatashsky, E; Zaroura, S, 1983)
"Overall, the most profound effects of convulsions on pharmacokinetic data were seen with mepivacaine."	1.27	Alterations in the pharmacokinetic properties of amide local anaesthetics following local anaesthetic induced convulsions. ( Arthur, GR; Covino, BG; Feldman, HS, 1988)
"On the 5th day the acute seizure threshold to intravenous bupivacaine was determined in both groups."	1.27	Long-term bupivacaine infusion does not alter the acute seizure threshold to bupivacaine in rats. ( Meidell, NK; Skeie, B; Steen, PA, 1988)
"Maternal convulsions and severe fetal bradycardia resulted from the accidental intravascular injection of 0."	1.27	[Cerebral convulsion following peridural anesthesia with bupivacaine in cesarean section]. ( Fischer, B; Knitza, R; Rhein, R; Sirtl, C; Wisser, J, 1988)
"On the fourth day the acute seizure threshold to bupivacaine was determined for both groups."	1.27	Effect of chronic bupivacaine infusion on seizure threshold to bupivacaine. ( Dodgson, MS; Forsman, M; Skeie, B; Steen, PA, 1987)
"The margin of safety between seizure onset and cardiovascular collapse was compared in lightly anesthetized and ventilated cats given an equipotent infusion of either lidocaine or bupivacaine (N = 10 for each group)."	1.27	Toxicity and resuscitation in lidocaine- or bupivacaine-infused cats. ( Chadwick, HS, 1985)
"min-1 decreased the seizure dosage of etidocaine but had no effect on that of bupivacaine."	1.26	Relation of etidocaine and bupivacaine toxicity to rate of infusion in rhesus monkeys. ( Embro, WJ; Malagodi, MH; Munson, ES, 1977)
"A case of convulsion due to inadvertent intravascular injection of bupivacaine during attempted epidural anaesthesia is presented."	1.26	Convulsions during epidural anaesthesia. A case report. ( Bean, E; Morrell, DF, 1981)
"Etidocaine and bupivacaine convulsions were more difficult to suppress than those induced by lidocaine."	1.26	Benzodiazepines protect mice from local anesthetic convulsions and deaths. ( Bonin, JD; de Jong, RH, 1981)
"The conclusion of this study was that a respiratory acidosis increased the central nervous system toxicity of local anaesthetics and that the underlying metabolic conditions modified this increase."	1.25	Central nervous system effects of local anaesthetic agents. ( Englesson, S; Matousek, M, 1975)
"Diazepam was also effective in terminating established seizure activity resulting from bupivacaine."	1.25	Central nervous system effects of bupivacaine. ( Jenkins, LC; Robinson, WM, 1975)

Timeframe	Studies, this research(%)	All Research%
pre-1990	60 (48.78)	18.7374
1990's	28 (22.76)	18.2507
2000's	22 (17.89)	29.6817
2010's	12 (9.76)	24.3611
2020's	1 (0.81)	2.80

Trial	Phase	Enrollment	Study Type	Start Date	Status
An Investigation Into the Effects of Intravenous Lipid Emulsion (ILE) on the Pharmacokinetic and Pharmacodynamic Properties of Metoprolol.[NCT02924454]	Phase 4	10 participants (Actual)	Interventional	2016-09-30	Completed
Early Versus Late Deflation of Distal Tourniquet in Intravenous Regional Anesthesia With and Without Ketorolac in Hand & Forearm Surgery[NCT05234619]		80 participants (Anticipated)	Interventional	2022-01-01	Active, not recruiting
A Randomized Controlled Trial to Investigate the Efficacy of a Bier's Block Compared to a Mini-bier's Block in Patients Undergoing Hand Surgery[NCT03761329]		280 participants (Actual)	Interventional	2018-11-12	Completed
Efficiency of Intravenous Lidocaine to Reduce Coughing and the Hemodynamic Changes Associated to Tracheal Extubation[NCT03731429]	Phase 4	144 participants (Anticipated)	Interventional	2019-04-05	Recruiting
The Immune Response of Breast Cancer Patients Treated With Levobupivacaine Using Paravertebral or Superficial Chest Blocks[NCT05816538]		100 participants (Anticipated)	Interventional	2023-04-30	Not yet recruiting
Red Blood Cell Validation of Magnesium Deficiency as Determined by a Muscle Stretch Test[NCT04130620]		50 participants (Actual)	Observational	2021-10-15	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
Adverse events associated with intravenous regional anesthesia (Bier block): a systematic review of complications. Journal of clinical anesthesia, 2009, Volume: 21, Issue:8 Topics: Anesthesia, Conduction; Anesthesia, Intravenous; Anesthetics, Local; Bupivacaine; Dose-Response Rela	2009
Adverse events associated with intravenous regional anesthesia (Bier block): a systematic review of complications. Journal of clinical anesthesia, 2009, Volume: 21, Issue:8 Topics: Anesthesia, Conduction; Anesthesia, Intravenous; Anesthetics, Local; Bupivacaine; Dose-Response Rela	2009
Adverse events associated with intravenous regional anesthesia (Bier block): a systematic review of complications. Journal of clinical anesthesia, 2009, Volume: 21, Issue:8 Topics: Anesthesia, Conduction; Anesthesia, Intravenous; Anesthetics, Local; Bupivacaine; Dose-Response Rela	2009
Adverse events associated with intravenous regional anesthesia (Bier block): a systematic review of complications. Journal of clinical anesthesia, 2009, Volume: 21, Issue:8 Topics: Anesthesia, Conduction; Anesthesia, Intravenous; Anesthetics, Local; Bupivacaine; Dose-Response Rela	2009
[Clinical safety with ropivacaine administration]. Revista espanola de anestesiologia y reanimacion, 2002, Volume: 49, Issue:3 Topics: Adult; Amides; Analgesia, Epidural; Analgesia, Obstetrical; Anesthetics, Local; Bupivacaine; Edema;	2002
Toxic systemic reactions of bupivacaine and etidocaine. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics, 1995, Volume: 79, Issue:1 Topics: Anesthesia, Dental; Anesthesia, Local; Animals; Arrhythmias, Cardiac; Bupivacaine; Cardiovascular Sy	1995

Article	Year
Propofol sedation during awake craniotomy for seizures: patient-controlled administration versus neurolept analgesia. Anesthesia and analgesia, 1997, Volume: 84, Issue:6 Topics: Adjuvants, Anesthesia; Adult; Analgesia, Patient-Controlled; Analgesics, Opioid; Anticonvulsants; An	1997
Axillary brachial plexus block with ropivacaine 7.5 mg/ml. A comparative study with bupivacaine 5 mg/ml. Acta anaesthesiologica Scandinavica, 1999, Volume: 43, Issue:8 Topics: Adult; Amides; Analgesics; Anesthetics, Local; Arm; Axilla; Brachial Plexus; Bupivacaine; Double-Bli	1999

Article	Year
Bupivacaine-Induced Systemic Toxicity in a Hair Transplantation Procedure. Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 2021, 04-01, Volume: 47, Issue:4 Topics: Adult; Anesthetics, Local; Bupivacaine; Fat Emulsions, Intravenous; Hair; Humans; Male; Seizures	2021
Awake caudal anaesthesia in neonates/young infants for improved patient safety. BMJ case reports, 2017, May-27, Volume: 2017 Topics: Adenosine; Adjuvants, Anesthesia; Anesthesia, Caudal; Anti-Arrhythmia Agents; Bupivacaine; Fat Emuls	2017
Successful resuscitation of a three month old child with intralipid infusion, presumed to have bupivacaine induced seizures and cardiovascular complications: case report. East African medical journal, 2010, Volume: 87, Issue:8 Topics: Anesthetics, Local; Arrhythmias, Cardiac; Bupivacaine; Fat Emulsions, Intravenous; Humans; Infant; M	2010
Successful Resuscitation With Intralipid After Marcaine Overdose. Aesthetic surgery journal, 2014, Volume: 34, Issue:5 Topics: Adult; Anesthetics, Local; Bupivacaine; Drug Overdose; Emulsions; Female; Heart Arrest; Humans; Infu	2014
Convulsions during cataract surgery under peribulbar anesthesia: a case report. Journal of medical case reports, 2014, Jun-23, Volume: 8 Topics: Aged; Anesthesia, Local; Anesthetics, Local; Bupivacaine; Cataract Extraction; Humans; Injections; L	2014
Protective effects of bupivacaine against kainic acid-induced seizure and neuronal cell death in the rat hippocampus. Biological & pharmaceutical bulletin, 2015, Volume: 38, Issue:4 Topics: Animals; Anti-Inflammatory Agents; Anticonvulsants; Behavior, Animal; Bupivacaine; CA3 Region, Hippo	2015
Sudden developing convulsion during interscalene block: Does propofol anesthesia diminish plasma bupivacaine level? Agri : Agri (Algoloji) Dernegi'nin Yayin organidir = The journal of the Turkish Society of Algology, 2015, Volume: 27, Issue:1 Topics: Aged; Anesthetics, Intravenous; Anesthetics, Local; Brachial Plexus; Bupivacaine; Diagnosis, Differe	2015
Effectiveness of retigabine against levobupivacaine-induced central nervous system toxicity: a prospective, randomized animal study. Journal of anesthesia, 2016, Volume: 30, Issue:1 Topics: Animals; Anticonvulsants; Bupivacaine; Carbamates; Central Nervous System; KCNQ2 Potassium Channel;	2016
Seizure After Abdominal Surgery in an Infant Receiving a Standard-Dose Postoperative Epidural Bupivacaine Infusion. A & A case reports, 2016, Apr-15, Volume: 6, Issue:8 Topics: Anesthetics, Local; Bupivacaine; Female; Hernia, Umbilical; Humans; Infant; Postoperative Period; Se	2016
Recurrence of cardiotoxicity after lipid rescue from bupivacaine-induced cardiac arrest. Anesthesia and analgesia, 2009, Volume: 108, Issue:4 Topics: Adult; Amiodarone; Anesthetics, Local; Anti-Arrhythmia Agents; Brachial Plexus; Bupivacaine; Cardiop	2009
The systemic toxicity of equipotent proxymetacaine, oxybuprocaine, and bupivacaine during continuous intravenous infusion in rats. Anesthesia and analgesia, 2010, Jan-01, Volume: 110, Issue:1 Topics: Analgesia; Anesthetics, Local; Animals; Bupivacaine; Dose-Response Relationship, Drug; Hemodynamics;	2010
Systemic dextromethorphan and dextrorphan are less toxic in rats than bupivacaine at equianesthetic doses. Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2011, Volume: 58, Issue:1 Topics: Anesthetics, Local; Animals; Apnea; Bupivacaine; Dextromethorphan; Dextrorphan; Dose-Response Relati	2011
Local anesthetic toxicity in interscalene block: clinical series. Minerva anestesiologica, 2010, Volume: 76, Issue:12 Topics: Aged; Amides; Anesthetics, Combined; Anesthetics, Local; Bupivacaine; Female; Humans; Lidocaine; Mal	2010
Fatality involving complications of bupivacaine toxicity and hypersensitivity reaction. Journal of forensic sciences, 2011, Volume: 56, Issue:5 Topics: Adult; Anesthetics, Local; Atrial Septum; Bradycardia; Bupivacaine; Cardiomegaly; Drug Hypersensitiv	2011
Convulsions following axillary brachial plexus blockade with levobupivacaine. Anaesthesia, 2002, Volume: 57, Issue:12 Topics: Anesthetics, Local; Axilla; Brachial Plexus; Bupivacaine; Female; Humans; Middle Aged; Nerve Block;	2002
A response to 'Convulsions following axillary brachial plexus blockade with levobupivacaine', Pirotta D, Sprigge J, Anaesthesia 2002; 57: 1187-9. Anaesthesia, 2003, Volume: 58, Issue:4 Topics: Anesthetics, Local; Brachial Plexus; Bupivacaine; Humans; Nerve Block; Seizures; Stereoisomerism	2003
Seizure after levobupivacaine for interscalene brachial plexus block. Anesthesia and analgesia, 2003, Volume: 96, Issue:4 Topics: Adult; Anesthetics, Local; Brachial Plexus; Bupivacaine; Female; Humans; Hypnotics and Sedatives; Mi	2003
Neurally-mediated cardiotoxicity of local anesthetics: direct effect of seizures or of local anesthetics? Anesthesiology, 2003, Volume: 98, Issue:5 Topics: Amides; Anesthetics, Local; Animals; Bupivacaine; Heart; Models, Animal; Myocardium; Ropivacaine; Se	2003
Convulsions following axillary brachial plexus blockade with levobupivacaine. Anaesthesia, 2003, Volume: 58, Issue:6 Topics: Anesthetics, Local; Brachial Plexus; Bupivacaine; Humans; Nerve Block; Seizures; Stereoisomerism	2003
Convulsions following axillary brachial plexus blockade with levobupivacaine. Anaesthesia, 2003, Volume: 58, Issue:6 Topics: Anesthetics, Local; Brachial Plexus; Bupivacaine; Humans; Nerve Block; Seizures; Stereoisomerism	2003
The P-glycoprotein inhibitor quinidine decreases the threshold for bupivacaine-induced, but not lidocaine-induced, convulsions in rats. Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2003, Volume: 50, Issue:8 Topics: Anesthetics, Local; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood Gas Anal	2003
Safety of levobupivacaine? Anesthesia and analgesia, 2003, Volume: 97, Issue:5 Topics: Anesthetics, Local; Bupivacaine; Diffusion; Humans; Nerve Block; Seizures; Stereoisomerism	2003
Vasodilation increases the threshold for bupivacaine-induced convulsions in rats. Anesthesia and analgesia, 2004, Volume: 98, Issue:3 Topics: Adrenergic alpha-Antagonists; Anesthetics, Local; Animals; Blood Gas Analysis; Blood Pressure; Brain	2004
Magnesium and bupivacaine-induced convulsions in awake pregnant rats. International journal of obstetric anesthesia, 2005, Volume: 14, Issue:1 Topics: Anesthetics, Local; Animals; Bupivacaine; Female; Magnesium Sulfate; Pregnancy; Rats; Rats, Sprague-	2005
Dexmedetomidine decreases the convulsive potency of bupivacaine and levobupivacaine in rats: involvement of alpha2-adrenoceptor for controlling convulsions. Anesthesia and analgesia, 2005, Volume: 100, Issue:3 Topics: Animals; Bupivacaine; Dexmedetomidine; Hypnotics and Sedatives; Levobupivacaine; Male; Rats; Rats, S	2005
Comparative effects of levobupivacaine and racemic bupivacaine on excitotoxic neuronal death in culture and N-methyl-D-aspartate-induced seizures in mice. European journal of pharmacology, 2005, Aug-22, Volume: 518, Issue:2-3 Topics: Animals; Astrocytes; Bupivacaine; Cell Survival; Cells, Cultured; Cerebral Cortex; Dose-Response Rel	2005
Levobupivacaine-induced seizures and cardiovascular collapse treated with Intralipid. Anaesthesia, 2007, Volume: 62, Issue:5 Topics: Aged; Anesthetics, Local; Bupivacaine; Fat Emulsions, Intravenous; Female; Heart Arrest; Humans; Int	2007
Reversal of local anaesthetic induced CNS toxicity with lipid emulsion. Anaesthesia, 2008, Volume: 63, Issue:2 Topics: Aged; Anesthetics, Local; Bupivacaine; Fat Emulsions, Intravenous; Female; Humans; Seizures	2008
The effects of general anesthesia on the central nervous and cardiovascular system toxicity of local anesthetics. Anesthesia and analgesia, 2008, Volume: 106, Issue:5 Topics: Acid-Base Equilibrium; Amides; Anesthetics, Inhalation; Anesthetics, Local; Animals; Arrhythmias, Ca	2008
Flunitrazepam protects mice against lidocaine and bupivacaine-induced convulsions. Canadian Anaesthetists' Society journal, 1983, Volume: 30, Issue:1 Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Bupivacaine; Diazepam; Dose-Response Relationship, Dr	1983
A comparison of flunitrazepam and diazepam in the prevention of local anesthetic-induced convulsions. Israel journal of medical sciences, 1983, Volume: 19, Issue:3 Topics: Animals; Anti-Anxiety Agents; Bupivacaine; Diazepam; Female; Flunitrazepam; Lidocaine; Mice; Seizure	1983
Convulsions and ventricular tachycardia from bupivacaine with epinephrine: successful resuscitation. Anesthesia and analgesia, 1984, Volume: 63, Issue:9 Topics: Adult; Bupivacaine; Drug Interactions; Epinephrine; Humans; Intraoperative Complications; Male; Resu	1984
The influence of serum potassium on the cerebral and cardiac toxicity of bupivacaine and lidocaine. Anesthesiology, 1984, Volume: 61, Issue:2 Topics: Animals; Bupivacaine; Cardiac Output; Dogs; Electrocardiography; Electroencephalography; Female; Hea	1984
Concerning the use and abuse of test doses for epidural anesthesia. Anesthesiology, 1984, Volume: 61, Issue:3 Topics: Anesthesia, Epidural; Anesthesiology; Bupivacaine; Epinephrine; Female; Humans; Pregnancy; Seizures	1984
Todd's paralysis following an interscalene block. Anesthesiology, 1984, Volume: 61, Issue:3 Topics: Adult; Bupivacaine; Female; Hemiplegia; Humans; Nerve Block; Primidone; Seizures	1984
Oral flunitrazepam in the prevention of local anaesthetic-induced convulsions in mice. Canadian Anaesthetists' Society journal, 1984, Volume: 31, Issue:6 Topics: Administration, Oral; Anesthetics, Local; Animals; Bupivacaine; Flunitrazepam; Lidocaine; Male; Mice	1984
[Unexpected intravenous penetration of an epidural catheter]. Regional-Anaesthesie, 1984, Volume: 7, Issue:4 Topics: Adult; Anesthesia, Epidural; Bupivacaine; Catheterization; Humans; Intraoperative Complications; Mal	1984
[Cerebral seizures during peridural anaesthesia (systemic reaction following bupivacaine 0.75%)]. Regional-Anaesthesie, 1983, Volume: 6, Issue:3 Topics: Adult; Anesthesia, Epidural; Bupivacaine; Diazepam; Epinephrine; Humans; Male; Seizures	1983
Local anesthetic toxicity: review and case studies. AANA journal, 1983, Volume: 51, Issue:3 Topics: Adolescent; Adult; Anesthetics, Local; Bupivacaine; Cardiovascular System; Central Nervous System; D	1983
Plasma level of bupivacaine during convulsions. Anaesthesia and intensive care, 1983, Volume: 11, Issue:4 Topics: Anesthesia, Epidural; Bupivacaine; Child; Female; Humans; Seizures	1983
Bupivacaine-induced cardiac arrhythmias in sheep. Anesthesiology, 1984, Volume: 60, Issue:1 Topics: Animals; Arrhythmias, Cardiac; Blood Pressure; Bupivacaine; Cardiac Output; Electrocardiography; Fem	1984
Bupivacaine toxicity in association with extradural analgesia for caesarean section. British journal of anaesthesia, 1984, Volume: 56, Issue:5 Topics: Adult; Anesthesia, Epidural; Anesthesia, Obstetrical; Bupivacaine; Cesarean Section; Cyanosis; Femal	1984
Intravenous regional analgesia. The danger of the congested arm and the value of occlusion pressure. Anaesthesia, 1984, Volume: 39, Issue:5 Topics: Adolescent; Adult; Aged; Anesthesia, Conduction; Anesthesia, Intravenous; Arm; Blood Pressure; Bupiv	1984
Severe hypoxia and acidosis following local anesthetic-induced convulsions. Anesthesiology, 1980, Volume: 53, Issue:3 Topics: Acidosis; Adolescent; Adult; Anesthesia, Local; Blood; Bupivacaine; Carbon Dioxide; Female; Humans;	1980
Systemic reaction caused by epidural bupivacaine 0.75%. Anaesthesia, 1983, Volume: 38, Issue:1 Topics: Anesthesia, Epidural; Bupivacaine; Female; Humans; Seizures	1983
Comparative CNS toxicity of lidocaine, etidocaine, bupivacaine, and tetracaine in awake dogs following rapid intravenous administration. Anesthesia and analgesia, 1983, Volume: 62, Issue:4 Topics: Acetanilides; Animals; Arrhythmias, Cardiac; Bupivacaine; Cardiovascular System; Cats; Central Nervo	1983
Possible role of epinephrine in prevention or correction of myocardial depression associated with bupivacaine. Anesthesia and analgesia, 1983, Volume: 62, Issue:4 Topics: Adult; Aged; Anesthesia, Local; Anesthesia, Obstetrical; Bupivacaine; Epinephrine; Female; Heart; He	1983
Convulsions following regional hip blockade with bupivacaine and adrenaline. Anaesthesia, 1983, Volume: 38, Issue:6 Topics: Aged; Bupivacaine; Epinephrine; Female; Hip; Humans; Male; Middle Aged; Nerve Block; Obturator Nerve	1983
Long-acting local anesthetic drugs and convulsions with hypoxia and acidosis. Anesthesiology, 1982, Volume: 56, Issue:3 Topics: Acidosis; Adult; Anesthetics, Local; Bupivacaine; Female; Humans; Hypoxia; Middle Aged; Seizures	1982
Intravenous regional analgesia using bupivacaine. Anaesthesia, 1982, Volume: 37, Issue:3 Topics: Adolescent; Anesthesia, Conduction; Anesthesia, Intravenous; Bupivacaine; Humans; Male; Seizures	1982
Deaths from local anesthetic-induced convulsions in mice. Anesthesia and analgesia, 1980, Volume: 59, Issue:6 Topics: Anesthetics, Local; Animals; Bupivacaine; Dose-Response Relationship, Drug; Female; Injections, Intr	1980
Benzodiazepines protect mice from local anesthetic convulsions and deaths. Anesthesia and analgesia, 1981, Volume: 60, Issue:6 Topics: Anesthetics; Animals; Benzodiazepines; Bupivacaine; Diazepam; Drug Interactions; Etidocaine; Female;	1981
Cardiovascular effects of convulsant and supraconvulsant doses of amide local anesthetics. Anesthesia and analgesia, 1982, Volume: 61, Issue:1 Topics: Anesthetics, Local; Animals; Blood Pressure; Bupivacaine; Cats; Dose-Response Relationship, Drug; El	1982
Convulsions during epidural anaesthesia. A case report. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1981, Jul-11, Volume: 60, Issue:2 Topics: Anesthesia, Epidural; Bupivacaine; Clinical Competence; Humans; Injections, Intravenous; Middle Aged	1981
Convulsant blood levels of bupivacaine. Anesthesiology, 1981, Volume: 55, Issue:4 Topics: Bupivacaine; Humans; Seizures	1981
Neuromuscular blocking agents do not alter local anesthetic seizure thresholds. Experimental neurology, 1981, Volume: 74, Issue:2 Topics: Animals; Bupivacaine; Cats; Electrocardiography; Electroencephalography; Gallamine Triethiodide; Neu	1981
Toxicity of local anesthetic mixtures. Toxicology and applied pharmacology, 1980, Volume: 54, Issue:3 Topics: Anesthetics, Local; Animals; Bupivacaine; Drug Combinations; Female; Lethal Dose 50; Lidocaine; Mice	1980
Inadvertent intravascular injections during lumbar epidural anesthesia. Anesthesiology, 1981, Volume: 54, Issue:2 Topics: Anesthesia, Epidural; Anesthesia, Local; Bupivacaine; Female; Humans; Injections, Intravenous; Medic	1981
Mixtures of local anesthetics are no more toxic than the parent drugs. Anesthesiology, 1981, Volume: 54, Issue:3 Topics: Anesthetics, Local; Animals; Bupivacaine; Drug Combinations; Female; Lethal Dose 50; Lidocaine; Mice	1981
Regional anesthesia and local anesthetic-induced systemic toxicity: seizure frequency and accompanying cardiovascular changes. Anesthesia and analgesia, 1995, Volume: 81, Issue:2 Topics: Adult; Anesthesia, Caudal; Anesthesia, Epidural; Anesthetics; Anesthetics, Local; Blood Pressure; Br	1995
Effect of four potassium channel agonists on bupivacaine-induced toxicity in mice. Life sciences, 1995, Volume: 57, Issue:10 Topics: Animals; Benzopyrans; Bupivacaine; Cromakalim; Diazoxide; Dose-Response Relationship, Drug; Guanidin	1995
Comparative systemic toxicity of ropivacaine and bupivacaine in nonpregnant and pregnant ewes. Anesthesiology, 1995, Volume: 82, Issue:3 Topics: Amides; Animals; Apnea; Blood Pressure; Bupivacaine; Dose-Response Relationship, Drug; Double-Blind	1995
Epidural analgesia in children. Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1994, Volume: 41, Issue:7 Topics: Analgesia, Epidural; Anesthesia, Conduction; Anesthesia, General; Bupivacaine; Child; Humans; Infant	1994
Complications of continuous epidural infusions for postoperative analgesia in children. Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1994, Volume: 41, Issue:7 Topics: Adolescent; Analgesia; Analgesia, Epidural; Bacterial Infections; Bupivacaine; Catheterization; Chil	1994
Convulsions following bupivacaine infiltration for excision of carotid body tumour. Anaesthesia and intensive care, 1993, Volume: 21, Issue:6 Topics: Aged; Anesthesia, Local; Bupivacaine; Carotid Body Tumor; Female; Humans; Injections, Intra-Arterial	1993
Effects of calcium channel blockers on bupivacaine-induced toxicity. Life sciences, 1993, Volume: 53, Issue:21 Topics: Animals; Bupivacaine; Calcium Channel Blockers; Convulsants; Dose-Response Relationship, Drug; Drug	1993
Comparison of propofol with thiopentone for treatment of bupivacaine-induced seizures in rats. British journal of anaesthesia, 1993, Volume: 71, Issue:5 Topics: Animals; Blood Pressure; Bupivacaine; Electrocardiography; Electroencephalography; Heart Rate; Propo	1993
Toxicity of bupivacaine encapsulated into liposomes and injected intravenously: comparison with plain solutions. Anesthesia and analgesia, 1993, Volume: 76, Issue:3 Topics: Animals; Bupivacaine; Drug Carriers; Heart Arrest; Infusions, Intravenous; Liposomes; Rabbits; Seizu	1993
Sevoflurane is equivalent to isoflurane for attenuating bupivacaine-induced arrhythmias and seizures in rats. Anesthesia and analgesia, 1996, Volume: 83, Issue:3 Topics: Anesthetics, Inhalation; Anesthetics, Local; Animals; Arrhythmias, Cardiac; Blood Pressure; Bupivaca	1996
Cardiovascular and central nervous system effects of intravenous levobupivacaine and bupivacaine in sheep. Anesthesia and analgesia, 1998, Volume: 86, Issue:4 Topics: Anesthetics, Local; Animals; Arrhythmias, Cardiac; Blood Pressure; Brain; Bupivacaine; Cardiac Outpu	1998
Bupivacaine-induced seizures and ventricular fibrillation in a 13-year-old girl undergoing wound debridement. Pediatric emergency care, 1998, Volume: 14, Issue:5 Topics: Acute Disease; Adolescent; Anesthetics, Local; Anticonvulsants; Bupivacaine; Debridement; Diazepam;	1998
A comparison of the effects of propofol and sevoflurane on the systemic toxicity of intravenous bupivacaine in rats. Anesthesia and analgesia, 1999, Volume: 88, Issue:1 Topics: Anesthetics, Inhalation; Anesthetics, Intravenous; Anesthetics, Local; Animals; Arrhythmias, Cardiac	1999
Epidural analgesia in children with cerebral palsy. Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1998, Volume: 45, Issue:12 Topics: Analgesia, Epidural; Analgesics, Opioid; Anesthetics, Local; Bupivacaine; Cerebral Palsy; Child; Con	1998
The intravascular migration of an epidural catheter. Paediatric anaesthesia, 1999, Volume: 9, Issue:3 Topics: Anesthesia, Epidural; Anesthetics, Local; Bupivacaine; Catheterization; Epidural Space; Foreign-Body	1999
Nitric oxide modulation affects the tissue distribution and toxicity of bupivacaine. Pharmacology, biochemistry, and behavior, 2000, Volume: 66, Issue:3 Topics: Anesthetics, Local; Animals; Arrhythmias, Cardiac; Bupivacaine; Drug Interactions; Enzyme Inhibitors	2000
Tolerability of large-dose intravenous levobupivacaine in sheep. Anesthesia and analgesia, 2000, Volume: 91, Issue:3 Topics: Acid-Base Equilibrium; Anesthetics, Local; Animals; Bupivacaine; Electrocardiography; Female; Half-L	2000
The successful use of regional anesthesia to prevent involuntary movements in a patient undergoing awake craniotomy. Anesthesia and analgesia, 2000, Volume: 91, Issue:5 Topics: Anesthetics, Local; Brain Mapping; Bupivacaine; Craniotomy; Extremities; Humans; Immobilization; Mal	2000
Systemic toxicity of levobupivacaine, bupivacaine, and ropivacaine during continuous intravenous infusion to nonpregnant and pregnant ewes. Anesthesiology, 2001, Volume: 95, Issue:5 Topics: Amides; Anesthetics, Local; Animals; Bupivacaine; Female; Hemodynamics; Hypotension; Infusions, Intr	2001
Central nervous system effects of local anaesthetic agents. British journal of anaesthesia, 1975, Volume: 47 suppl Topics: Acid-Base Equilibrium; Acidosis, Respiratory; Allyl Compounds; Amines; Anesthetics, Local; Anilides;	1975
Relation of etidocaine and bupivacaine toxicity to rate of infusion in rhesus monkeys. British journal of anaesthesia, 1977, Volume: 49, Issue:2 Topics: Acetanilides; Animals; Arrhythmias, Cardiac; Bupivacaine; Central Nervous System; Etidocaine; Haplor	1977
Convulsive arterial plasma levels of bupivacaine and the response to diazepam therapy. Anesthesiology, 1979, Volume: 50, Issue:5 Topics: Adult; Aged; Bupivacaine; Diazepam; Female; Humans; Seizures	1979
Cardiac arrest following regional anesthesia with etidocaine or bupivacaine. Anesthesiology, 1979, Volume: 51, Issue:4 Topics: Acetanilides; Anesthesia, Conduction; Bupivacaine; Dose-Response Relationship, Drug; Etidocaine; Hea	1979
Sterilization of anesthetic apparatus. Anesthesiology, 1978, Volume: 48, Issue:5 Topics: Anesthesia, Epidural; Anesthesia, Obstetrical; Bupivacaine; Female; Humans; Seizures	1978
Bupivacaine-induced seizure after accidental intravenous injection, a complication of epidural anesthesia. Anesthesiology, 1977, Volume: 47, Issue:5 Topics: Adult; Anesthesia, Epidural; Bupivacaine; Female; Humans; Injections, Intravenous; Seizures	1977
Etidocaine, bupivacaine, and lidocaine seizure thresholds in monkeys. Anesthesiology, 1975, Volume: 42, Issue:4 Topics: Acetanilides; Acid-Base Equilibrium; Anesthesia, Local; Anesthetics, Local; Animals; Behavior, Anima	1975
Central nervous system effects of bupivacaine. Canadian Anaesthetists' Society journal, 1975, Volume: 22, Issue:3 Topics: Amygdala; Anesthesia, General; Animals; Arrhythmias, Cardiac; Blood Pressure; Brain; Bupivacaine; Ca	1975
Sheep: a model for testing spinal and epidural anesthetic agents. Laboratory animal science, 1975, Volume: 25, Issue:5 Topics: Anesthesia, Epidural; Anesthesia, Spinal; Animals; Bupivacaine; Seizures; Sheep; Sheep Diseases; Tet	1975
Bupivacaine toxicity secondary to continuous caudal epidural infusion in children. Anesthesia and analgesia, 1992, Volume: 75, Issue:2 Topics: Anesthesia, Caudal; Arrhythmias, Cardiac; Bupivacaine; Child; Child, Preschool; Female; Humans; Infa	1992
Acute cardiovascular and central nervous system toxicity of bupivacaine and desbutylbupivacaine in the rat. Acta anaesthesiologica Scandinavica, 1992, Volume: 36, Issue:2 Topics: Animals; Arrhythmias, Cardiac; Blood Pressure; Bupivacaine; Depression, Chemical; Electroencephalogr	1992
Severe hypoxia enhances central nervous system and cardiovascular toxicity of bupivacaine in lightly anesthetized pigs. Anesthesiology, 1992, Volume: 77, Issue:1 Topics: Anesthesia, Inhalation; Animals; Arrhythmias, Cardiac; Blood Pressure; Bupivacaine; Electroencephalo	1992
Seizures occurring in pediatric patients receiving continuous infusion of bupivacaine. Anesthesia and analgesia, 1992, Volume: 75, Issue:2 Topics: Analgesia, Epidural; Bupivacaine; Child; Child, Preschool; Female; Humans; Pain, Postoperative; Pleu	1992
Treatment of acute systemic toxicity after the rapid intravenous injection of ropivacaine and bupivacaine in the conscious dog. Anesthesia and analgesia, 1991, Volume: 73, Issue:4 Topics: Amides; Anesthetics, Local; Animals; Blood Pressure; Bupivacaine; Dogs; Epinephrine; Heart Rate; Hyp	1991
Bupivacaine toxicity after stellate ganglion block. Anesthesia and analgesia, 1991, Volume: 73, Issue:4 Topics: Bupivacaine; Humans; Nerve Block; Seizures; Stellate Ganglion	1991
Flumazenil and bupivacaine-induced toxicity: inverse agonist type activity. Life sciences, 1991, Volume: 49, Issue:23 Topics: Animals; Bupivacaine; Chi-Square Distribution; Drug Interactions; Flumazenil; Male; Mice; Mice, Inbr	1991
The effect of magnesium sulfate administration on cerebral and cardiac toxicity of bupivacaine in dogs. Anesthesiology, 1990, Volume: 72, Issue:2 Topics: Animals; Arrhythmias, Cardiac; Brain; Bupivacaine; Dogs; Electrocardiography; Electroencephalography	1990
Pregnancy does not alter lidocaine toxicity. American journal of obstetrics and gynecology, 1990, Volume: 162, Issue:5 Topics: Animals; Blood Pressure; Bupivacaine; Female; Heart Rate; Hypotension; Lidocaine; Mepivacaine; Pregn	1990
Bupivacaine toxicity in young pigs is age-dependent and is affected by volatile anesthetics. Anesthesiology, 1990, Volume: 73, Issue:2 Topics: Aging; Animals; Arrhythmias, Cardiac; Blood Pressure; Bupivacaine; Cardiac Output; Drug Interactions	1990
Comparative systemic toxicity of convulsant and supraconvulsant doses of intravenous ropivacaine, bupivacaine, and lidocaine in the conscious dog. Anesthesia and analgesia, 1989, Volume: 69, Issue:6 Topics: Amides; Animals; Arrhythmias, Cardiac; Bupivacaine; Carbon Dioxide; Dogs; Dose-Response Relationship	1989
Myocardial and cerebral drug concentrations and the mechanisms of death after fatal intravenous doses of lidocaine, bupivacaine, and ropivacaine in the sheep. Anesthesia and analgesia, 1989, Volume: 69, Issue:3 Topics: Amides; Anesthetics, Local; Animals; Brain; Bupivacaine; Cause of Death; Hemodynamics; Infusions, In	1989
Hemodynamic and central nervous system effects of intravenous bolus doses of lidocaine, bupivacaine, and ropivacaine in sheep. Anesthesia and analgesia, 1989, Volume: 69, Issue:3 Topics: Acid-Base Equilibrium; Amides; Anesthetics, Local; Animals; Bupivacaine; Hemodynamics; Injections, I	1989
Effect of epinephrine on central nervous system and cardiovascular system toxicity of bupivacaine in pigs. Anesthesiology, 1989, Volume: 71, Issue:5 Topics: Animals; Arrhythmias, Cardiac; Bupivacaine; Cardiovascular System; Central Nervous System; Dose-Resp	1989
Decreased susceptibility to local anesthetics-induced convulsions after paradoxical sleep deprivation. Psychopharmacology, 1988, Volume: 94, Issue:1 Topics: Anesthetics, Local; Animals; Bupivacaine; Lidocaine; Male; Mice; Pentylenetetrazole; Seizures; Sleep	1988
Alterations in the pharmacokinetic properties of amide local anaesthetics following local anaesthetic induced convulsions. Acta anaesthesiologica Scandinavica, 1988, Volume: 32, Issue:7 Topics: Anesthetics, Local; Animals; Bupivacaine; Dogs; Etidocaine; Lidocaine; Male; Mepivacaine; Seizures	1988
Long-term bupivacaine infusion does not alter the acute seizure threshold to bupivacaine in rats. Anesthesia and analgesia, 1988, Volume: 67, Issue:1 Topics: Acute Disease; Animals; Brain; Bupivacaine; Dose-Response Relationship, Drug; Infusion Pumps; Male;	1988
[Cerebral convulsion following peridural anesthesia with bupivacaine in cesarean section]. Geburtshilfe und Frauenheilkunde, 1988, Volume: 48, Issue:1 Topics: Adult; Anesthesia, Epidural; Anesthesia, General; Anesthesia, Obstetrical; Bupivacaine; Cesarean Sec	1988
[Neurotoxicity and cardiotoxicity of bupivacaine on the Papio papio baboon]. Annales francaises d'anesthesie et de reanimation, 1987, Volume: 6, Issue:5 Topics: Animals; Arrhythmias, Cardiac; Bupivacaine; Diazepam; Drug Interactions; Hypertension; Papio; Seizur	1987
Occasional seizures that can follow retrobulbar anesthesia with bupivacaine 0.75%. Annals of ophthalmology, 1987, Volume: 19, Issue:3 Topics: Anesthesia, Local; Bupivacaine; Eye; Humans; Seizures	1987
Effect of chronic bupivacaine infusion on seizure threshold to bupivacaine. Acta anaesthesiologica Scandinavica, 1987, Volume: 31, Issue:5 Topics: Animals; Brain; Bupivacaine; Differential Threshold; Infusion Pumps; Osmolar Concentration; Rats; Se	1987
Does hyperkalemia contraindicate the use of bupivacaine or the use of succinylcholine to treat bupivacaine-induced toxicity in humans? Anesthesiology, 1985, Volume: 62, Issue:2 Topics: Arteriovenous Shunt, Surgical; Brachial Plexus; Bupivacaine; Heart; Humans; Hyperkalemia; Nerve Bloc	1985
Convulsions and ventricular tachycardia from bupivacaine with epinephrine: successful resuscitation--congratulations! Anesthesia and analgesia, 1985, Volume: 64, Issue:8 Topics: Bupivacaine; Epinephrine; Humans; Seizures; Succinylcholine; Tachycardia	1985
Persistent phrenic nerve paresis following interscalene brachial plexus block. Anesthesiology, 1985, Volume: 63, Issue:1 Topics: Brachial Plexus; Bupivacaine; Diaphragm; Humans; Male; Middle Aged; Movement; Nerve Block; Paralysis	1985
Bupivacaine toxicity in pregnant and nonpregnant ewes. Anesthesiology, 1985, Volume: 63, Issue:2 Topics: Animals; Blood Pressure; Bupivacaine; Dose-Response Relationship, Drug; Etidocaine; Female; Fetus; H	1985
Toxicity and resuscitation in lidocaine- or bupivacaine-infused cats. Anesthesiology, 1985, Volume: 63, Issue:4 Topics: Anesthesia, Inhalation; Animals; Blood Pressure; Bupivacaine; Cats; Electrocardiography; Electroence	1985
Caudal anesthesia complicated by intraosseous injection in a patient with ankylosing spondylitis. Anesthesiology, 1985, Volume: 63, Issue:6 Topics: Adult; Anesthesia, Caudal; Anesthesia, Epidural; Bone Marrow; Bupivacaine; Epinephrine; Humans; Inje	1985
Etidocaine (Duranest): a clinical and laboratory evaluation. Acta anaesthesiologica Scandinavica, 1974, Volume: 18, Issue:3 Topics: Acetanilides; Adjuvants, Anesthesia; Aged; Anesthetics, Local; Brachial Plexus; Bupivacaine; Chromat	1974
Diazepam treatment of local anesthetic-induced seizures. Anesthesiology, 1972, Volume: 37, Issue:5 Topics: Anesthetics, Local; Animals; Blood Gas Analysis; Bupivacaine; Diazepam; Dose-Response Relationship,	1972
Bupivacaine and lignocaine induced seizures in rhesus monkeys. British journal of anaesthesia, 1972, Volume: 44, Issue:10 Topics: Animals; Behavior, Animal; Blood; Bupivacaine; Carbon Dioxide; Consciousness; Electroencephalography	1972
Accidental intravenous injection of bupivacaine: a complication of obstetrical epidural anaesthesia. Case report. British journal of anaesthesia, 1973, Volume: 45, Issue:8 Topics: Adult; Anesthesia, Epidural; Anesthesia, Obstetrical; Bupivacaine; Electroencephalography; Female; H	1973

bupivacaine and Seizures

Research Excerpts

Research

Studies (123)

Authors

Clinical Trials (6)

Trial Overview

Reviews

Trials

Other Studies

Authors	Studies
Ağaçkiran, İ	1
Özdamar, Y	1
İlhan, B	1
Aksu, NM	1
Lim, WY	1
Wijeratne, SA	1
Lim, EHL	1
Admani, B	1
Essajee, F	1
Whiteman, DM	1
Kushins, SI	1
Bensghir, M	1
Badou, N	1
Houba, A	1
Balkhi, H	1
Haimeur, C	1
Azendour, H	1
Chiu, KM	1
Wu, CC	1
Wang, MJ	1
Lee, MY	1
Wang, SJ	1
Güngör, İ	1
Akbaş, B	1
Kaya, K	1
Çelebi, H	1
Tamer, U	1
Cheng, Y	1
Li, H	1
Li, J	1
Chen, Y	1
Duan, R	1
Yuan, J	1
Zhao, S	1
Shapiro, P	1
Schroeck, H	1
Marwick, PC	1
Levin, AI	1
Coetzee, AR	1
Hung, CH	2
Liu, KS	1
Shao, DZ	1
Cheng, KI	1
Chen, YC	2
Chen, YW	2
Guay, J	1
Wang, JJ	1
Liu, TY	1
Nishiyama, T	1
Komatsu, K	1
Dudley, MH	1
Fleming, SW	1
Garg, U	1
Edwards, JM	1
Fornet Ruiz, I	1
Palacio Abizanda, FJ	1
Gilsanz, F	1
Pirotta, D	1
Sprigge, J	1
McCartney, CJ	1
Crews, JC	2
Rothman, TE	1
de La Coussaye, JE	1
Aya, AG	1
Eledjam, JJ	1
Cumming, C	1
Barker, K	1
Dhileepan, S	1
Davis, N	1
Funao, T	3
Oda, Y	3
Tanaka, K	3
Asada, A	3
Okutomi, T	1
Zhang, Y	1
Cooper, TB	1
Morishima, HO	4
Takahashi, R	1
Hamaoka, N	1
Marganella, C	1
Bruno, V	1
Matrisciano, F	1
Reale, C	1
Nicoletti, F	1
Melchiorri, D	1
Foxall, G	1
McCahon, R	1
Lamb, J	1
Hardman, JG	1
Bedforth, NM	1
Whiteside, J	1
Copeland, SE	1
Ladd, LA	2
Gu, XQ	1
Mather, LE	5
Vatashsky, E	3
Aronson, HB	3
Zaroura, S	1
Mallampati, SR	1
Liu, PL	2
Knapp, RM	1
Avery, P	1
Redon, D	1
Schaenzer, G	1
Rusy, B	1
Abouleish, E	1
Bourke, D	1
Collier, HW	1
Engelking, K	1
Beilin, B	1
Weinstock, M	1
Seeling, W	1
Heinrich, H	1
Bhate, H	2
Kalil, AL	1
Eyres, RL	1
Brown, TC	1
Hastings, C	1
Kotelko, DM	1
Shnider, SM	1
Dailey, PA	1
Brizgys, RV	1
Levinson, G	1
Shapiro, WA	1
Koike, M	1
Rosen, MA	1
Thorburn, J	1
Moir, DD	1
Davies, JA	1
Hall, ID	1
Wilkey, AD	1
Smith, JE	1
Walford, AJ	1
Kale, VR	1
Moore, DC	7
Crawford, RD	2
Scurlock, JE	2
Feldman, HS	5
Giasi, R	1
Patterson, MK	1
Covino, BG	6
Coates, DP	1
Sanders, R	1
Edmonds-Seal, J	1
Thompson, GE	2
Hanton, RJ	1
Punchihewa, VG	1
de Jong, RH	6
Bonin, JD	5
Ronfeld, RA	1
DeRosa, RA	1
Morrell, DF	1
Bean, E	1
Fitzgibbons, DC	1
Balfour, RI	2
Gamble, CA	1
Kenepp, NB	1
Gutsche, BB	1
Bacsik, CJ	1
Swift, JQ	1
Hargreaves, KM	1
Brown, DL	2
Ransom, DM	1
Hall, JA	1
Leicht, CH	1
Schroeder, DR	1
Offord, KP	1
Gantenbein, M	1
Attolini, L	1
Bruguerolle, B	3
Santos, AC	2
Arthur, GR	6
Wlody, D	1
De Armas, P	1
Finster, M	3
Berde, C	1
Wood, CE	1
Goresky, GV	1
Klassen, KA	1
Kuwahara, B	1
Neil, SG	1
Brooker, CD	1
Lawson, AD	1
Heavner, JE	5
Arthur, J	1
Zou, J	1
McDaniel, K	1
Tyman-Szram, B	1
Rosenberg, PH	2
Boogaerts, J	1
Declercq, A	1
Lafont, N	1
Benameur, H	1
Akodad, EM	1
Dupont, JC	1
Legros, FJ	1
Fukuda, H	1
Hirabayashi, Y	1
Shimizu, R	1
Saitoh, K	1
Mitsuhata, H	1
Herrick, IA	1
Craen, RA	1
Gelb, AW	1
Miller, LA	1
Kubu, CS	1
Girvin, JP	1
Parrent, AG	1
Eliasziw, M	1
Kirkby, J	1
Huang, YF	1
Pryor, ME	1
Veering, BT	1
Yan, AC	1
Newman, RD	1
Ohmura, S	1
Ohta, T	1
Yamamoto, K	1
Kobayashi, T	1
Brenn, BR	1
Brislin, RP	1
Rose, JB	1
Dickson, MA	1
Doyle, E	1
Raeder, JC	1
Drøsdahl, S	1
Klaastad, O	1
Kvalsvik, O	1
Isaksen, B	1
Strømskag, KE	1
Mowinckel, P	1
Bergheim, R	1
Selander, D	1
Shi, B	1
Chang, DH	1
Wilson, KA	1
Gelgor, L	1
Gebhard, RE	1
Berry, J	1
Maggio, WW	1
Gollas, A	1
Chelly, JE	1
DeArmas, PI	1
Englesson, S	1
Matousek, M	1
Malagodi, MH	2
Munson, ES	4
Embro, WJ	1
Fitzgibbons, D	1
Albright, GA	1
Beck, WC	1
Yamashiro, H	1
Tucker, WK	1
Ausinsch, B	1
Robinson, WM	1
Jenkins, LC	1
Lebeaux, M	1
McCloskey, JJ	1
Haun, SE	1
Deshpande, JK	1
Dryden, CF	1
Sanghani, V	1
Huemer, G	1
Bessire, A	1
Badgwell, JM	2
Agarwal, R	1
Gutlove, DP	1
Lockhart, CH	1
Pitkanen, M	1
Hurley, R	1
Doucette, AM	1
Romanoff, ME	1
Ellis, JS	1
Emperaire, N	1
Solomon, D	1
Bunegin, L	1
Albin, M	1
Kytta, J	1
Nancarrow, C	2
Rutten, AJ	2
Runciman, WB	2
Carapetis, RJ	1
McLean, CF	1
Hipkins, SF	1
Ilsley, AH	1
Upton, RN	1
Bernards, CM	1
Carpenter, RL	1
Kenter, ME	1
Rupp, SM	1
Vale, NB	1
Leite, JR	1
Skeie, B	2
Meidell, NK	1
Steen, PA	2
Knitza, R	1
Sirtl, C	1
Wisser, J	1
Rhein, R	1
Fischer, B	1
Emperaire-Le Pouleuf, N	1
Ottomani, A	1
Mathers, WD	1
Dodgson, MS	1
Forsman, M	1
Bridenbaugh, LD	1
Bonica, JJ	1
Bashein, G	1
Robertson, HT	1
Kennedy, WF	1
Pedersen, H	1
Hiraoka, H	1
Tsuji, A	1
Chadwick, HS	1
Weber, S	1
Lund, PC	1
Cwik, JC	1
Gannon, RT	1
Wagman, IH	2
Martucci, RW	1
Ryan, DW	1