bupivacaine and Scoliosis studies

Bupivacaine: A widely used local anesthetic agent.
1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide : A piperidinecarboxamide obtained by formal condensation of the carboxy group of N-butylpipecolic acid with the amino group of 2,6-dimethylaniline.
bupivacaine : A racemate composed of equimolar amounts of dextrobupivacaine and levobupivacaine. Used (in the form of its hydrochloride hydrate) as a local anaesthetic.

Scoliosis: An appreciable lateral deviation in the normally straight vertical line of the spine. (Dorland, 27th ed)

Research Excerpts

Excerpt	Relevance	Reference
"This study evaluated the effectiveness of dexmedetomidine in decreasing opioid use in children with adolescent idiopathic scoliosis following posterior spinal fusion surgery at a pediatric tertiary care hospital over the past 10 years."	7.80	Evaluation of dexmedetomidine and postoperative pain management in patients with adolescent idiopathic scoliosis: conclusions based on a retrospective study at a tertiary pediatric hospital. ( Cotugno, RE; Hotz, J; Jones, JS; Nebar, S; Parke, EJ; Semenova, J; Shrader, MW; Singhal, NR; Soares, N, 2014)
"This study evaluated the effectiveness of dexmedetomidine in decreasing opioid use in children with adolescent idiopathic scoliosis following posterior spinal fusion surgery at a pediatric tertiary care hospital over the past 10 years."	3.80	Evaluation of dexmedetomidine and postoperative pain management in patients with adolescent idiopathic scoliosis: conclusions based on a retrospective study at a tertiary pediatric hospital. ( Cotugno, RE; Hotz, J; Jones, JS; Nebar, S; Parke, EJ; Semenova, J; Shrader, MW; Singhal, NR; Soares, N, 2014)
" This study provides an excellent platform on which to build future trials that could include increased baseline dosing for the epidural medications, radiographic confirmation of catheter placement, and dual catheter techniques toward the goal of improving pain control in these patients."	2.74	Epidural analgesia compared with intravenous analgesia after pediatric posterior spinal fusion. ( Burke, CN; Caird, MS; Farley, FA; Gauger, VT; Kostrzewa, AJ; Voepel-Lewis, TD; Wagner, DS, 2009)
" The overall incidence of adverse events was low and consisted primarily of technical problems and postoperative nausea and vomiting."	2.73	Safety and efficacy of patient controlled epidural analgesia following pediatric spinal surgery. ( Ceroni, D; Greenberg, RS; Habre, W; Kaelin, A; Meyer, PA; Saudan, S; von Ungern-Sternberg, BS, 2008)
"Kyphoscoliosis is a progressive disease that worsens with age."	1.38	[Combined spinal epidural anesthesia in a patient with advanced kyphoscoliosis]. ( Akyol, O; Ozyuvaci, EN; Solak, S; Solak, Z; Toprak, N; Tuluk, G, 2012)
"If epidural catheters for postoperative pain relief are used in scoliosis surgery, current practice is the intraoperative placement of the TEC by the surgeon because preoperative placement is considered challenging and dangerous."	1.36	Feasibility and efficacy of preoperative epidural catheter placement for anterior scoliosis surgery. ( Bullmann, V; Ertmer, C; Liljenqvist, UR; Möllmann, M; Pöpping, DM; Weber, TP; Wenk, M, 2010)

Research

Studies (25)

Authors

Clinical Trials (3)

Trial Overview

Trial Outcomes

Length of Hospital Stay

Number of Participants Experiencing Delirium

Number of Participants Readmitted to Hospital Within 30 Days of Surgery

Number of Participants With Adverse Events Related to the Study

Timeframe	Studies, this research(%)	All Research%
pre-1990	2 (8.00)	18.7374
1990's	6 (24.00)	18.2507
2000's	7 (28.00)	29.6817
2010's	9 (36.00)	24.3611
2020's	1 (4.00)	2.80

Authors	Studies
Stondell, C	1
Roberto, R	1
Ibrahim, MH	1
Thompson, ME	1
Kai-Hong Chan, A	1
Choy, W	1
Miller, CA	1
Robinson, LC	1
Mummaneni, PV	1
Jones, JS	1
Cotugno, RE	1
Singhal, NR	1
Soares, N	1
Semenova, J	1
Nebar, S	1
Parke, EJ	1
Shrader, MW	1
Hotz, J	1
Chin, KJ	2
Perlas, A	2
Chan, V	1
Gauger, VT	1
Voepel-Lewis, TD	1
Burke, CN	1
Kostrzewa, AJ	1
Caird, MS	1
Wagner, DS	1
Farley, FA	1
Chan, VW	1
Ramlogan, R	1
Wenk, M	1
Ertmer, C	1
Weber, TP	1
Liljenqvist, UR	1
Pöpping, DM	1
Möllmann, M	1
Bullmann, V	1
Sundarathiti, P	1
Pasutharnchat, K	1
Jommaroeng, P	1
Ross, PA	1
Smith, BM	1
Tolo, VT	1
Khemani, RG	1
Solak, S	1
Ozyuvaci, EN	1
Tuluk, G	1
Solak, Z	1
Akyol, O	1
Toprak, N	1
Sucato, DJ	1
Duey-Holtz, A	1
Elerson, E	1
Safavi, F	1
Ozyurt, G	1
Basagan-Mogol, E	1
Bilgin, H	1
Tokat, O	1
Okutomi, T	1
Saito, M	1
Koura, M	1
Hoka, S	1
Saudan, S	1
Habre, W	1
Ceroni, D	1
Meyer, PA	1
Greenberg, RS	1
Kaelin, A	1
von Ungern-Sternberg, BS	1
Pham Dang, C	1
Delécrin, J	1
Péréon, Y	1
Falconi, I	1
Passuti, N	1
Malinge, M	1
Pinaud, M	1
Purnell, RJ	1
Loughman, BA	1
Fennelly, ME	1
Henley, M	1
Hall, GM	1
Kardash, K	1
King, BW	1
Datta, S	1
Hilton, AB	1
Lockhart, EM	1
Penning, DH	1
Van Boerum, DH	1
Smith, JT	1
Curtin, MJ	1
Howard, R	1
Anderson, W	1
Moran, DH	1
Johnson, MD	1
Wardall, GJ	1
Frame, WT	1
McDonald, NJ	1
Stritch, M	1
MacEvilly, M	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Patient-controlled Intermittent Epidural Bolus Versus Epidural Infusion for Posterior Spinal Fusion After Adolescent Idiopathic Scoliosis[NCT02669004]	Phase 4	47 participants (Actual)	Interventional	2015-06-30	Completed
Feasibility Study of the Use of Real-time Ultrasound Guidance to Administer Spinal Anesthesia[NCT01326988]		100 participants (Actual)	Observational	2011-04-30	Completed
A Comparison of Epidural Analgesia With Standard Care Following Lumbar Spinal Fusion: A Prospective Randomized Study[NCT01986946]	Phase 3	17 participants (Actual)	Interventional	2013-10-31	Terminated (stopped due to Lack of recruitment.)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Intervention	days (Mean)
Intravenous Opioids	4.4
Epidural Catheter	4.33

Intervention	participants (Number)
Intravenous Opioids	0
Epidural Catheter	0

Intervention	participants (Number)
Intravenous Opioids	0
Epidural Catheter	0

Intervention	participants (Number)
Intravenous Opioids	0
Epidural Catheter	0

Intervention	participants (Number)
Intravenous Opioids	0
Epidural Catheter	0

Patients will be assessed in the recovery room and each day of their epidural or intravenous opioid infusions, and at their surgical follow-up visit. (NCT01986946)
Timeframe: 6-week Follow up Visit

Patient Satisfaction With Overall Care

Intervention	participants (Number)
Intravenous Opioids	0
Epidural Catheter	0

Likert scale ranges from 1 to 5 (1=very satisfied and 5=Very Dissatisfied). (NCT01986946)
Timeframe: 6-Week Follow up Visit

Patient Satisfaction With Perioperative Analgesia

Intervention	units on a scale (Mean)
Intravenous Opioids	1
Epidural Catheter	1.5

Patients will be assessed for satisfaction with their peri-operative analgesia in the recovery room and each day of their epidural infusion or intravenous opioid infusion by the Acute Pain Service, and at their surgical follow-up visit. Likert scale ranges from 1 to 5 (1=very satisfied and 5=Very Dissatisfied). (NCT01986946)
Timeframe: 6-Week Follow up Visit

Patient Satisfaction With Perioperative Analgesia

Intervention	units on a scale (Mean)
Intravenous Opioids	2
Epidural Catheter	1.5

Post-operative Pain as Assessed by Visual Analogue Scale (VAS)

Intervention	units on a scale (Mean)
Intravenous Opioids	2.4
Epidural Catheter	1.29

The VAS scale ranges from 0 to 100 mm with the lower score indicating less pain and the higher score indicating greater pain. (NCT01986946)
Timeframe: Postoperative day 1

Article	Year
Epidural analgesia compared with intravenous analgesia after pediatric posterior spinal fusion. Journal of pediatric orthopedics, 2009, Volume: 29, Issue:6 Topics: Adolescent; Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthetics, Loc	2009
Safety and efficacy of patient controlled epidural analgesia following pediatric spinal surgery. Paediatric anaesthesia, 2008, Volume: 18, Issue:2 Topics: Adolescent; Adult; Analgesia, Epidural; Analgesia, Patient-Controlled; Anesthesia, General; Anesthet	2008
Epidural analgesia after scoliosis surgery: electrophysiologic and clinical assessment of the effects of bupivacaine 0.125% plus morphine versus ropivacaine 0.2% plus morphine. Journal of clinical anesthesia, 2008, Volume: 20, Issue:1 Topics: Adult; Amides; Analgesia, Epidural; Anesthetics; Bupivacaine; Double-Blind Method; Electroencephalog	2008

Article	Year
Erector Spinae Plane Blocks With Liposomal Bupivacaine for Pediatric Scoliosis Surgery. Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews, 2022, 01-21, Volume: 6, Issue:1 Topics: Adolescent; Analgesia, Epidural; Bupivacaine; Child; Humans; Nerve Block; Pain, Postoperative; Retro	2022
Ultrasound to facilitate thoracic paravertebral catheter in severe scoliosis. Journal of clinical anesthesia, 2018, Volume: 45 Topics: Anesthesia, General; Anesthetics, Local; Bupivacaine; Catheters; Female; Humans; Male; Nephrectomy;	2018
A novel technique for awake, minimally invasive transforaminal lumbar interbody fusion: technical note. Neurosurgical focus, 2019, 04-01, Volume: 46, Issue:4 Topics: Anesthesia, Local; Anesthesia, Spinal; Anesthetics, Local; Bupivacaine; Female; Humans; Liposomes; L	2019
Evaluation of dexmedetomidine and postoperative pain management in patients with adolescent idiopathic scoliosis: conclusions based on a retrospective study at a tertiary pediatric hospital. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 2014, Volume: 15, Issue:6 Topics: Adolescent; Analgesia, Patient-Controlled; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthetics	2014
The ultrasound-assisted paraspinous approach to lumbar neuraxial blockade: a simplified technique in patients with difficult anatomy. Acta anaesthesiologica Scandinavica, 2015, Volume: 59, Issue:5 Topics: Anesthesia, Spinal; Anesthetics, Local; Arthroplasty, Replacement, Knee; Bupivacaine; Female; Humans	2015
Real-time ultrasound-guided spinal anesthesia in patients with a challenging spinal anatomy: two case reports. Acta anaesthesiologica Scandinavica, 2010, Volume: 54, Issue:2 Topics: Aged; Aged, 80 and over; Anesthesia, Spinal; Anesthetics, Local; Bupivacaine; Dura Mater; Female; Hu	2010
Feasibility and efficacy of preoperative epidural catheter placement for anterior scoliosis surgery. Anesthesiology, 2010, Volume: 113, Issue:2 Topics: Adolescent; Anesthesia, Epidural; Bupivacaine; Catheters, Indwelling; Child; Feasibility Studies; Fe	2010
Thoracic epidural-general analgesia in scoliosis surgery. Journal of clinical anesthesia, 2010, Volume: 22, Issue:6 Topics: Adolescent; Aged; Analgesia, Epidural; Analgesics, Opioid; Anesthesia Recovery Period; Anesthesia, G	2010
Continuous infusion of bupivacaine reduces postoperative morphine use in adolescent idiopathic scoliosis after posterior spine fusion. Spine, 2011, Aug-15, Volume: 36, Issue:18 Topics: Adolescent; Analgesics, Opioid; Anesthetics, Local; Bupivacaine; Child; Dose-Response Relationship,	2011
[Combined spinal epidural anesthesia in a patient with advanced kyphoscoliosis]. Agri : Agri (Algoloji) Dernegi'nin Yayin organidir = The journal of the Turkish Society of Algology, 2012, Volume: 24, Issue:1 Topics: Anesthesia, Epidural; Anesthesia, Spinal; Anesthetics, Local; Bupivacaine; Female; Femoral Fractures	2012
Postoperative analgesia following surgical correction for adolescent idiopathic scoliosis: a comparison of continuous epidural analgesia and patient-controlled analgesia. Spine, 2005, Jan-15, Volume: 30, Issue:2 Topics: Adolescent; Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthetics, Loc	2005
Spinal anesthesia in a patient with severe thoracolumbar kyphoscoliosis. The Tohoku journal of experimental medicine, 2005, Volume: 207, Issue:3 Topics: Adjuvants, Anesthesia; Adult; Anesthesia, Spinal; Anesthetics, Local; Bupivacaine; Fentanyl; Humans;	2005
Spinal anesthesia using a continuous spinal catheter for cesarean section in a parturient with prior surgical correction of scoliosis. Journal of anesthesia, 2006, Volume: 20, Issue:3 Topics: Adult; Anesthesia, Obstetrical; Anesthesia, Spinal; Anesthetics, Intravenous; Anesthetics, Local; Bu	2006
Scoliosis correction and epidural analgesia. Prolonged block following Harrington rod insertion. Anaesthesia, 1982, Volume: 37, Issue:11 Topics: Anesthesia, Epidural; Bupivacaine; Child; Female; Humans; Methods; Orthopedic Fixation Devices; Para	1982
The effects of differing concentrations of bupivacaine on the epidural somatosensory evoked potential after posterior tibial nerve stimulation. Anesthesia and analgesia, 1995, Volume: 81, Issue:1 Topics: Adolescent; Analgesia, Epidural; Anesthesia, Inhalation; Anesthesia, Intravenous; Blood Pressure; Bu	1995
Spinal anaesthesia for caesarean section after Harrington instrumentation. Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1993, Volume: 40, Issue:7 Topics: Adult; Anesthesia, Obstetrical; Anesthesia, Spinal; Bupivacaine; Cesarean Section; Female; Humans; I	1993
Epidural analgesia in parturients with previous spinal irradiation. Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1998, Volume: 45, Issue:9 Topics: Adolescent; Adult; Analgesia, Epidural; Analgesia, Obstetrical; Analgesics, Opioid; Anesthetics, Loc	1998
A comparison of the effects of patient-controlled analgesia with intravenous opioids versus Epidural analgesia on recovery after surgery for idiopathic scoliosis. Spine, 2000, Sep-15, Volume: 25, Issue:18 Topics: Adolescent; Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthetics, Loc	2000
Subdural catheterization and opiate administration in a patient with Harrington rods. Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1990, Volume: 37, Issue:6 Topics: Adult; Anesthesia, Epidural; Anesthesia, Obstetrical; Bupivacaine; Female; Fentanyl; Humans; Lumbar	1990
Continuous spinal anesthesia with combined hyperbaric and isobaric bupivacaine in a patient with scoliosis. Anesthesia and analgesia, 1990, Volume: 70, Issue:4 Topics: Adult; Anesthesia, Obstetrical; Anesthesia, Spinal; Bupivacaine; Cesarean Section; Female; Heart Def	1990
Extradural anaesthesia for caesarean section in achondroplasia. British journal of anaesthesia, 1990, Volume: 64, Issue:3 Topics: Achondroplasia; Adult; Anesthesia, Epidural; Anesthesia, Obstetrical; Bupivacaine; Cesarean Section;	1990
Extradural bupivacaine: a neurological complication. Irish journal of medical science, 1987, Volume: 156, Issue:10 Topics: Adolescent; Bupivacaine; Horner Syndrome; Humans; Injections, Epidural; Male; Scoliosis	1987

bupivacaine and Scoliosis

Research Excerpts

Research

Studies (25)

Authors

Clinical Trials (3)

Trial Overview

Trial Outcomes

Length of Hospital Stay

Number of Participants Experiencing Delirium

Number of Participants Experiencing Delirium

Number of Participants Experiencing Delirium

Number of Participants Readmitted to Hospital Within 30 Days of Surgery

Number of Participants With Adverse Events Related to the Study

Patient Satisfaction With Overall Care

Patient Satisfaction With Perioperative Analgesia

Patient Satisfaction With Perioperative Analgesia

Post-operative Pain as Assessed by Visual Analogue Scale (VAS)

Total Post-operative Opioid Consumption

Trials

Other Studies