Page last updated: 2024-10-24

bupivacaine and Sciatica

bupivacaine has been researched along with Sciatica in 27 studies

Bupivacaine: A widely used local anesthetic agent.
1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide : A piperidinecarboxamide obtained by formal condensation of the carboxy group of N-butylpipecolic acid with the amino group of 2,6-dimethylaniline.
bupivacaine : A racemate composed of equimolar amounts of dextrobupivacaine and levobupivacaine. Used (in the form of its hydrochloride hydrate) as a local anaesthetic.

Sciatica: A condition characterized by pain radiating from the back into the buttock and posterior/lateral aspects of the leg. Sciatica may be a manifestation of SCIATIC NEUROPATHY; RADICULOPATHY (involving the SPINAL NERVE ROOTS; L4, L5, S1, or S2, often associated with INTERVERTEBRAL DISK DISPLACEMENT); or lesions of the CAUDA EQUINA.

Research Excerpts

ExcerptRelevanceReference
"We describe a prospective, randomized controlled trial (RCT), with the aim to evaluate the hypothesis that TESI plus Levobupivacaine (TESI-plus) added to oral pain medication is more effective compared to pain medication alone or compared to transforaminal injection with a local anesthetic of short duration among patients with acute sciatica."5.24Treatment of acute sciatica with transforaminal epidural corticosteroids and local anesthetic: design of a randomized controlled trial. ( de Boer, MR; de Priester, K; Maas, ET; Ostelo, RWJG; Ter Meulen, BC; van der Vegt, M; van Tulder, MW; Vyas, A; Weinstein, HC, 2017)
"In this study 160 consecutive, eligible patients with sciatica who had unilateral symptoms of 1 to 6 months duration, and who never underwent surgery were randomized for double-blind injection with methylprednisolone bupivacaine combination or saline."5.09Periradicular infiltration for sciatica: a randomized controlled trial. ( Karppinen, J; Kurunlahti, M; Kyllönen, E; Malmivaara, A; Nieminen, P; Ohinmaa, A; Pienimäki, T; Tervonen, O; Vanharanta, H, 2001)
"A 50-year-old man had an inguinal hernia repair under spinal anaesthesia with bupivacaine."3.69[Delayed low back pain after spinal anesthesia]. ( Abderrazak, M; Boncoeur, MP; Desport, JC; Guillaume, A; Sardin, B, 1995)
" Adverse events were uncommon, with no difference between groups."2.71Cost-effectiveness and safety of epidural steroids in the management of sciatica. ( Arden, N; Coglan, L; Price, C; Rogers, P, 2005)
"Infiltration procedures are a common treatment of lumbar radiculopathy."1.42CT-guided infiltration saves surgical intervention and fastens return to work compared to anatomical landmark-guided infiltration in patients with lumbosciatica. ( Buhr, M; Deml, MC; Kabir, K; Pflugmacher, R; Riedel, R; Rommelspacher, Y; Wimmer, MD, 2015)
"The treatment of piriformis syndrome includes injections into the piriformis muscle around the sciatic nerve."1.40CT-guided piriformis muscle injection for the treatment of piriformis syndrome. ( Denk, CC; Gundogmus, B; Ozisik, PA; Taskiran, OO; Toru, M, 2014)
"Lumbosciatica is a common condition which is associated with significant pain and disability."1.34Interlaminar epidural corticosteroid injection in the treatment of lumbosciatic pain: a retrospective analysis. ( Bastos, MP; Gomez, RS; Gusmão, S; Silva, JF, 2007)

Research

Studies (27)

TimeframeStudies, this research(%)All Research%
pre-19905 (18.52)18.7374
1990's5 (18.52)18.2507
2000's10 (37.04)29.6817
2010's5 (18.52)24.3611
2020's2 (7.41)2.80

Authors

AuthorsStudies
Hofmann, UK1
Keller, RL1
von Bernstorff, M1
Walter, C1
Mittag, F1
Shamov, T1
Al-Hashel, JY1
Rоusseff, RT1
Ter Meulen, BC1
Maas, ET1
Vyas, A1
van der Vegt, M1
de Priester, K1
de Boer, MR1
van Tulder, MW1
Weinstein, HC1
Ostelo, RWJG1
Roth, KE1
Kremer, M1
Maier, GS1
Sariyar, M1
Rompe, JD1
Kappis, B1
Ozisik, PA1
Toru, M1
Denk, CC1
Taskiran, OO1
Gundogmus, B1
Deml, MC1
Buhr, M1
Wimmer, MD1
Pflugmacher, R1
Riedel, R1
Rommelspacher, Y1
Kabir, K1
Tafazal, S1
Ng, L1
Chaudhary, N1
Sell, P1
Cohen, SP1
White, RL1
Kurihara, C1
Larkin, TM1
Chang, A1
Griffith, SR1
Gilligan, C1
Larkin, R1
Morlando, B1
Pasquina, PF1
Yaksh, TL1
Nguyen, C1
Patel, N1
Broadhurst, NA1
Simmons, DN1
Bond, MJ1
Filler, AG1
Haynes, J1
Jordan, SE1
Prager, J1
Villablanca, JP1
Farahani, K1
McBride, DQ1
Tsuruda, JS1
Morisoli, B1
Batzdorf, U1
Johnson, JP1
Price, C1
Arden, N1
Coglan, L1
Rogers, P1
Gomez, RS1
Gusmão, S1
Silva, JF1
Bastos, MP1
Klenerman, L1
Greenwood, R1
Davenport, HT1
White, DC1
Peskett, S1
Knight, CL1
Burnell, JC1
Sardin, B1
Boncoeur, MP1
Desport, JC1
Abderrazak, M1
Guillaume, A1
Devulder, J1
Mercadante, S1
Serretta, R1
Sapio, M1
Villari, P1
Calderone, L1
Wu, SS1
Lee, CH1
Chen, PQ1
Yamauchi, Y1
Abe, S1
Sudo, S1
Kimura, S1
Nagaro, T1
Arai, T1
Ojala, R1
Vahala, E1
Karppinen, J3
Klemola, R1
Blanco-Sequeiros, R1
Vaara, T1
Tervonen, O3
Malmivaara, A2
Kurunlahti, M2
Kyllönen, E2
Pienimäki, T2
Nieminen, P2
Ohinmaa, A2
Vanharanta, H2
Manchikanti, L1
Singh, V1
Jennings, FO1
Delaney, EJ1
Dunlop, JB1
Haimsky, G1
Shir, Y1
Zagzag, D1
Robin, G1
Magora, F1
Knutsen, O1
Ygge, H1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
[NCT00733096]Phase 2/Phase 384 participants (Actual)Interventional2008-08-31Completed
Effect of Dexamethasone Dose and Route on Duration of Interscalene Brachial Plexus Block for Outpatient Arthroscopic Shoulder Surgery - A Randomized Controlled Trial[NCT02426736]Phase 4280 participants (Actual)Interventional2015-06-25Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Global Perceived Effect

Satisfaction. Number of participants with positive perceived global satisfaction. (NCT00733096)
Timeframe: 1 month

Interventionparticipants (Number)
Steroid23
Etanercept15
Saline17

Medication Reduction

Number of people who reduced medications (NCT00733096)
Timeframe: 1 month

Interventionparticipants (Number)
Steroid17
Etanercept9
Saline14

Numerical Rating Leg Pain Score

0-10 pain score. 0= no pain, 10= worst imaginable pain. (NCT00733096)
Timeframe: 1 month

Interventionunits on a scale (Mean)
Steroid2.54
Etanercept3.56
Saline3.78

Oswestry Disability Score

0-100%. 0= no disability, 100% is complete disability (NCT00733096)
Timeframe: 1 month

Interventionpercentage of disability out of 100% (Mean)
Steroid22.4
Etanercept40.26
Saline30.00

Trials

9 trials available for bupivacaine and Sciatica

ArticleYear
Treatment of acute sciatica with transforaminal epidural corticosteroids and local anesthetic: design of a randomized controlled trial.
    BMC musculoskeletal disorders, 2017, 05-25, Volume: 18, Issue:1

    Topics: Acute Disease; Adrenal Cortex Hormones; Anesthetics, Local; Bupivacaine; Drug Therapy, Combination;

2017
Corticosteroids in peri-radicular infiltration for radicular pain: a randomised double blind controlled trial. One year results and subgroup analysis.
    European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2009, Volume: 18, Issue:8

    Topics: Adrenal Cortex Hormones; Anesthetics, Local; Anti-Inflammatory Agents; Bupivacaine; Disability Evalu

2009
Epidural steroids, etanercept, or saline in subacute sciatica: a multicenter, randomized trial.
    Annals of internal medicine, 2012, Apr-17, Volume: 156, Issue:8

    Topics: Adult; Anesthetics, Local; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Bupiva

2012
Cost-effectiveness and safety of epidural steroids in the management of sciatica.
    Health technology assessment (Winchester, England), 2005, Volume: 9, Issue:33

    Topics: Acute Disease; Adolescent; Adult; Aged; Anesthetics, Local; Anti-Inflammatory Agents; Bupivacaine; C

2005
Lumbar epidural injections in the treatment of sciatica.
    British journal of rheumatology, 1984, Volume: 23, Issue:1

    Topics: Acupuncture Therapy; Bupivacaine; Female; Humans; Male; Methylprednisolone; Methylprednisolone Aceta

1984
Transforaminal nerve root sleeve injection with corticosteroids, hyaluronidase, and local anesthetic in the failed back surgery syndrome.
    Journal of spinal disorders, 1998, Volume: 11, Issue:2

    Topics: Adult; Analgesia; Anesthetics, Local; Anti-Inflammatory Agents; Back Pain; Bupivacaine; Cicatrix; Dr

1998
Nerve root infiltration of the first sacral root with MRI guidance.
    Journal of magnetic resonance imaging : JMRI, 2000, Volume: 12, Issue:4

    Topics: Bupivacaine; Contrast Media; Humans; Intervertebral Disc Displacement; Lumbosacral Plexus; Magnetic

2000
Periradicular infiltration for sciatica: a randomized controlled trial.
    Spine, 2001, May-01, Volume: 26, Issue:9

    Topics: Adult; Anesthetics, Local; Bupivacaine; Disease Progression; Drug Combinations; Drug Costs; Female;

2001
Cost effectiveness of periradicular infiltration for sciatica: subgroup analysis of a randomized controlled trial.
    Spine, 2001, Dec-01, Volume: 26, Issue:23

    Topics: Adult; Anesthetics, Local; Bupivacaine; Cost-Benefit Analysis; Double-Blind Method; Drug Combination

2001

Other Studies

18 other studies available for bupivacaine and Sciatica

ArticleYear
Predictability of the effects of epidural injection in lumbar spinal stenosis by assessment of lumbar MRI scans.
    Journal of back and musculoskeletal rehabilitation, 2020, Volume: 33, Issue:4

    Topics: Adult; Aged; Anti-Inflammatory Agents; Bupivacaine; Female; Glucocorticoids; Humans; Injections, Epi

2020
Fluoroscopic Epidural Steroid Injection: Pain Relief in Discogenic Sciatica Versus Lumbar Spinal Stenosis. A Study on Middle Eastern Patients.
    Acta medica (Hradec Kralove), 2020, Volume: 63, Issue:2

    Topics: Adult; Aged; Analgesia, Epidural; Anesthetics, Local; Anti-Inflammatory Agents; Bupivacaine; Case-Co

2020
[Epidural injection shows no advantages over oral medication and physiotherapy in the treatment of sciatica, irrespective of the duration of symptoms].
    Zeitschrift fur Orthopadie und Unfallchirurgie, 2014, Volume: 152, Issue:1

    Topics: Administration, Oral; Analgesics; Anesthetics, Local; Bupivacaine; Female; Humans; Injections, Epidu

2014
CT-guided piriformis muscle injection for the treatment of piriformis syndrome.
    Turkish neurosurgery, 2014, Volume: 24, Issue:4

    Topics: Adult; Aged; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Bupivacaine; Electromyogra

2014
CT-guided infiltration saves surgical intervention and fastens return to work compared to anatomical landmark-guided infiltration in patients with lumbosciatica.
    European journal of orthopaedic surgery & traumatology : orthopedie traumatologie, 2015, Volume: 25 Suppl 1

    Topics: Adult; Analgesics; Anatomic Landmarks; Anesthetics, Local; Anti-Inflammatory Agents; Bupivacaine; Fe

2015
Re: Karppinen J. et al. Periradicular infiltration for sciatica. A randomized controlled trial. Spine 26, 1059-1067:2001.
    Spine, 2002, Jul-15, Volume: 27, Issue:14

    Topics: Anesthetics, Local; Bupivacaine; Drug Combinations; Glucocorticoids; Humans; Injections; Methylpredn

2002
Piriformis syndrome: Correlation of muscle morphology with symptoms and signs.
    Archives of physical medicine and rehabilitation, 2004, Volume: 85, Issue:12

    Topics: Anesthetics, Local; Bupivacaine; Buttocks; Female; Humans; Low Back Pain; Male; Middle Aged; Muscle,

2004
Sciatica of nondisc origin and piriformis syndrome: diagnosis by magnetic resonance neurography and interventional magnetic resonance imaging with outcome study of resulting treatment.
    Journal of neurosurgery. Spine, 2005, Volume: 2, Issue:2

    Topics: Adult; Aged; Back; Bupivacaine; Diagnosis, Differential; Follow-Up Studies; Humans; Image Enhancemen

2005
Interlaminar epidural corticosteroid injection in the treatment of lumbosciatic pain: a retrospective analysis.
    Arquivos de neuro-psiquiatria, 2007, Volume: 65, Issue:4B

    Topics: Adult; Aged; Aged, 80 and over; Anesthetics, Local; Bupivacaine; Drug Therapy, Combination; Female;

2007
Systemic side-effects of extradural steroids.
    Anaesthesia, 1980, Volume: 35, Issue:6

    Topics: Anesthesia, Epidural; Bupivacaine; Female; Humans; Male; Methylprednisolone; Sciatica

1980
[Delayed low back pain after spinal anesthesia].
    Annales francaises d'anesthesie et de reanimation, 1995, Volume: 14, Issue:2

    Topics: Anesthesia, Spinal; Anesthetics, Local; Bupivacaine; Hernia, Inguinal; Humans; Low Back Pain; Magnet

1995
When all else fails: stepwise multiple solutions for a complex cancer pain syndrome.
    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 1999, Volume: 7, Issue:1

    Topics: Aged; Analgesics; Analgesics, Opioid; Anesthetics, Local; Bupivacaine; Cholinesterase Inhibitors; Cl

1999
Operative repair of symptomatic spondylolysis following a positive response to diagnostic pars injection.
    Journal of spinal disorders, 1999, Volume: 12, Issue:1

    Topics: Adolescent; Adult; Anesthetics, Local; Back Pain; Bupivacaine; Female; Humans; Injections, Spinal; L

1999
[A case of Guillain-Barrè syndrome with severe sciatica preceding motor paralysis in the lower extremities].
    Masui. The Japanese journal of anesthesiology, 1999, Volume: 48, Issue:2

    Topics: Analgesia, Epidural; Analgesia, Patient-Controlled; Anesthetics, Local; Bupivacaine; Humans; Leg; Ma

1999
Periradicular infiltration for sciatica.
    Spine, 2002, Feb-01, Volume: 27, Issue:3

    Topics: Bupivacaine; Humans; Injections, Epidural; Methylprednisolone; Randomized Controlled Trials as Topic

2002
Treatment of low back pain and sciatica with extradural analgesia and steroid injection 1971-1978.
    Irish medical journal, 1979, Sep-28, Volume: 72, Issue:9

    Topics: Adult; Anesthesia, Epidural; Back Pain; Bupivacaine; Dexamethasone; Epinephrine; Female; Humans; Mal

1979
[Continuous self-administered epidural methadone and Marcaine for low-back and sciatic pain].
    Harefuah, 1987, Jan-01, Volume: 112, Issue:1

    Topics: Anesthesia, Epidural; Back Pain; Bupivacaine; Humans; Infusion Pumps; Methadone; Sciatica; Self Admi

1987
Prolonged extradural anaesthesia with bupivacaine at lumbago and sciatica.
    Acta orthopaedica Scandinavica, 1971, Volume: 42, Issue:4

    Topics: Adult; Aged; Anesthesia, Epidural; Anesthetics, Local; Autonomic Nerve Block; Back Pain; Blood Press

1971