bupivacaine has been researched along with Sciatica in 27 studies
Bupivacaine: A widely used local anesthetic agent.
1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide : A piperidinecarboxamide obtained by formal condensation of the carboxy group of N-butylpipecolic acid with the amino group of 2,6-dimethylaniline.
bupivacaine : A racemate composed of equimolar amounts of dextrobupivacaine and levobupivacaine. Used (in the form of its hydrochloride hydrate) as a local anaesthetic.
Sciatica: A condition characterized by pain radiating from the back into the buttock and posterior/lateral aspects of the leg. Sciatica may be a manifestation of SCIATIC NEUROPATHY; RADICULOPATHY (involving the SPINAL NERVE ROOTS; L4, L5, S1, or S2, often associated with INTERVERTEBRAL DISK DISPLACEMENT); or lesions of the CAUDA EQUINA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We describe a prospective, randomized controlled trial (RCT), with the aim to evaluate the hypothesis that TESI plus Levobupivacaine (TESI-plus) added to oral pain medication is more effective compared to pain medication alone or compared to transforaminal injection with a local anesthetic of short duration among patients with acute sciatica." | 5.24 | Treatment of acute sciatica with transforaminal epidural corticosteroids and local anesthetic: design of a randomized controlled trial. ( de Boer, MR; de Priester, K; Maas, ET; Ostelo, RWJG; Ter Meulen, BC; van der Vegt, M; van Tulder, MW; Vyas, A; Weinstein, HC, 2017) |
| "In this study 160 consecutive, eligible patients with sciatica who had unilateral symptoms of 1 to 6 months duration, and who never underwent surgery were randomized for double-blind injection with methylprednisolone bupivacaine combination or saline." | 5.09 | Periradicular infiltration for sciatica: a randomized controlled trial. ( Karppinen, J; Kurunlahti, M; Kyllönen, E; Malmivaara, A; Nieminen, P; Ohinmaa, A; Pienimäki, T; Tervonen, O; Vanharanta, H, 2001) |
| "A 50-year-old man had an inguinal hernia repair under spinal anaesthesia with bupivacaine." | 3.69 | [Delayed low back pain after spinal anesthesia]. ( Abderrazak, M; Boncoeur, MP; Desport, JC; Guillaume, A; Sardin, B, 1995) |
| " Adverse events were uncommon, with no difference between groups." | 2.71 | Cost-effectiveness and safety of epidural steroids in the management of sciatica. ( Arden, N; Coglan, L; Price, C; Rogers, P, 2005) |
| "Infiltration procedures are a common treatment of lumbar radiculopathy." | 1.42 | CT-guided infiltration saves surgical intervention and fastens return to work compared to anatomical landmark-guided infiltration in patients with lumbosciatica. ( Buhr, M; Deml, MC; Kabir, K; Pflugmacher, R; Riedel, R; Rommelspacher, Y; Wimmer, MD, 2015) |
| "The treatment of piriformis syndrome includes injections into the piriformis muscle around the sciatic nerve." | 1.40 | CT-guided piriformis muscle injection for the treatment of piriformis syndrome. ( Denk, CC; Gundogmus, B; Ozisik, PA; Taskiran, OO; Toru, M, 2014) |
| "Lumbosciatica is a common condition which is associated with significant pain and disability." | 1.34 | Interlaminar epidural corticosteroid injection in the treatment of lumbosciatic pain: a retrospective analysis. ( Bastos, MP; Gomez, RS; Gusmão, S; Silva, JF, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (18.52) | 18.7374 |
| 1990's | 5 (18.52) | 18.2507 |
| 2000's | 10 (37.04) | 29.6817 |
| 2010's | 5 (18.52) | 24.3611 |
| 2020's | 2 (7.41) | 2.80 |
| Authors | Studies |
|---|---|
| Hofmann, UK | 1 |
| Keller, RL | 1 |
| von Bernstorff, M | 1 |
| Walter, C | 1 |
| Mittag, F | 1 |
| Shamov, T | 1 |
| Al-Hashel, JY | 1 |
| Rоusseff, RT | 1 |
| Ter Meulen, BC | 1 |
| Maas, ET | 1 |
| Vyas, A | 1 |
| van der Vegt, M | 1 |
| de Priester, K | 1 |
| de Boer, MR | 1 |
| van Tulder, MW | 1 |
| Weinstein, HC | 1 |
| Ostelo, RWJG | 1 |
| Roth, KE | 1 |
| Kremer, M | 1 |
| Maier, GS | 1 |
| Sariyar, M | 1 |
| Rompe, JD | 1 |
| Kappis, B | 1 |
| Ozisik, PA | 1 |
| Toru, M | 1 |
| Denk, CC | 1 |
| Taskiran, OO | 1 |
| Gundogmus, B | 1 |
| Deml, MC | 1 |
| Buhr, M | 1 |
| Wimmer, MD | 1 |
| Pflugmacher, R | 1 |
| Riedel, R | 1 |
| Rommelspacher, Y | 1 |
| Kabir, K | 1 |
| Tafazal, S | 1 |
| Ng, L | 1 |
| Chaudhary, N | 1 |
| Sell, P | 1 |
| Cohen, SP | 1 |
| White, RL | 1 |
| Kurihara, C | 1 |
| Larkin, TM | 1 |
| Chang, A | 1 |
| Griffith, SR | 1 |
| Gilligan, C | 1 |
| Larkin, R | 1 |
| Morlando, B | 1 |
| Pasquina, PF | 1 |
| Yaksh, TL | 1 |
| Nguyen, C | 1 |
| Patel, N | 1 |
| Broadhurst, NA | 1 |
| Simmons, DN | 1 |
| Bond, MJ | 1 |
| Filler, AG | 1 |
| Haynes, J | 1 |
| Jordan, SE | 1 |
| Prager, J | 1 |
| Villablanca, JP | 1 |
| Farahani, K | 1 |
| McBride, DQ | 1 |
| Tsuruda, JS | 1 |
| Morisoli, B | 1 |
| Batzdorf, U | 1 |
| Johnson, JP | 1 |
| Price, C | 1 |
| Arden, N | 1 |
| Coglan, L | 1 |
| Rogers, P | 1 |
| Gomez, RS | 1 |
| Gusmão, S | 1 |
| Silva, JF | 1 |
| Bastos, MP | 1 |
| Klenerman, L | 1 |
| Greenwood, R | 1 |
| Davenport, HT | 1 |
| White, DC | 1 |
| Peskett, S | 1 |
| Knight, CL | 1 |
| Burnell, JC | 1 |
| Sardin, B | 1 |
| Boncoeur, MP | 1 |
| Desport, JC | 1 |
| Abderrazak, M | 1 |
| Guillaume, A | 1 |
| Devulder, J | 1 |
| Mercadante, S | 1 |
| Serretta, R | 1 |
| Sapio, M | 1 |
| Villari, P | 1 |
| Calderone, L | 1 |
| Wu, SS | 1 |
| Lee, CH | 1 |
| Chen, PQ | 1 |
| Yamauchi, Y | 1 |
| Abe, S | 1 |
| Sudo, S | 1 |
| Kimura, S | 1 |
| Nagaro, T | 1 |
| Arai, T | 1 |
| Ojala, R | 1 |
| Vahala, E | 1 |
| Karppinen, J | 3 |
| Klemola, R | 1 |
| Blanco-Sequeiros, R | 1 |
| Vaara, T | 1 |
| Tervonen, O | 3 |
| Malmivaara, A | 2 |
| Kurunlahti, M | 2 |
| Kyllönen, E | 2 |
| Pienimäki, T | 2 |
| Nieminen, P | 2 |
| Ohinmaa, A | 2 |
| Vanharanta, H | 2 |
| Manchikanti, L | 1 |
| Singh, V | 1 |
| Jennings, FO | 1 |
| Delaney, EJ | 1 |
| Dunlop, JB | 1 |
| Haimsky, G | 1 |
| Shir, Y | 1 |
| Zagzag, D | 1 |
| Robin, G | 1 |
| Magora, F | 1 |
| Knutsen, O | 1 |
| Ygge, H | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| [NCT00733096] | Phase 2/Phase 3 | 84 participants (Actual) | Interventional | 2008-08-31 | Completed | ||
| Effect of Dexamethasone Dose and Route on Duration of Interscalene Brachial Plexus Block for Outpatient Arthroscopic Shoulder Surgery - A Randomized Controlled Trial[NCT02426736] | Phase 4 | 280 participants (Actual) | Interventional | 2015-06-25 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Satisfaction. Number of participants with positive perceived global satisfaction. (NCT00733096)
Timeframe: 1 month
| Intervention | participants (Number) |
|---|---|
| Steroid | 23 |
| Etanercept | 15 |
| Saline | 17 |
Number of people who reduced medications (NCT00733096)
Timeframe: 1 month
| Intervention | participants (Number) |
|---|---|
| Steroid | 17 |
| Etanercept | 9 |
| Saline | 14 |
0-10 pain score. 0= no pain, 10= worst imaginable pain. (NCT00733096)
Timeframe: 1 month
| Intervention | units on a scale (Mean) |
|---|---|
| Steroid | 2.54 |
| Etanercept | 3.56 |
| Saline | 3.78 |
0-100%. 0= no disability, 100% is complete disability (NCT00733096)
Timeframe: 1 month
| Intervention | percentage of disability out of 100% (Mean) |
|---|---|
| Steroid | 22.4 |
| Etanercept | 40.26 |
| Saline | 30.00 |
9 trials available for bupivacaine and Sciatica
| Article | Year |
|---|---|
Treatment of acute sciatica with transforaminal epidural corticosteroids and local anesthetic: design of a randomized controlled trial.
Topics: Acute Disease; Adrenal Cortex Hormones; Anesthetics, Local; Bupivacaine; Drug Therapy, Combination; | 2017 |
Corticosteroids in peri-radicular infiltration for radicular pain: a randomised double blind controlled trial. One year results and subgroup analysis.
Topics: Adrenal Cortex Hormones; Anesthetics, Local; Anti-Inflammatory Agents; Bupivacaine; Disability Evalu | 2009 |
Epidural steroids, etanercept, or saline in subacute sciatica: a multicenter, randomized trial.
Topics: Adult; Anesthetics, Local; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Bupiva | 2012 |
Cost-effectiveness and safety of epidural steroids in the management of sciatica.
Topics: Acute Disease; Adolescent; Adult; Aged; Anesthetics, Local; Anti-Inflammatory Agents; Bupivacaine; C | 2005 |
Lumbar epidural injections in the treatment of sciatica.
Topics: Acupuncture Therapy; Bupivacaine; Female; Humans; Male; Methylprednisolone; Methylprednisolone Aceta | 1984 |
Transforaminal nerve root sleeve injection with corticosteroids, hyaluronidase, and local anesthetic in the failed back surgery syndrome.
Topics: Adult; Analgesia; Anesthetics, Local; Anti-Inflammatory Agents; Back Pain; Bupivacaine; Cicatrix; Dr | 1998 |
Nerve root infiltration of the first sacral root with MRI guidance.
Topics: Bupivacaine; Contrast Media; Humans; Intervertebral Disc Displacement; Lumbosacral Plexus; Magnetic | 2000 |
Periradicular infiltration for sciatica: a randomized controlled trial.
Topics: Adult; Anesthetics, Local; Bupivacaine; Disease Progression; Drug Combinations; Drug Costs; Female; | 2001 |
Cost effectiveness of periradicular infiltration for sciatica: subgroup analysis of a randomized controlled trial.
Topics: Adult; Anesthetics, Local; Bupivacaine; Cost-Benefit Analysis; Double-Blind Method; Drug Combination | 2001 |
18 other studies available for bupivacaine and Sciatica
| Article | Year |
|---|---|
Predictability of the effects of epidural injection in lumbar spinal stenosis by assessment of lumbar MRI scans.
Topics: Adult; Aged; Anti-Inflammatory Agents; Bupivacaine; Female; Glucocorticoids; Humans; Injections, Epi | 2020 |
Fluoroscopic Epidural Steroid Injection: Pain Relief in Discogenic Sciatica Versus Lumbar Spinal Stenosis. A Study on Middle Eastern Patients.
Topics: Adult; Aged; Analgesia, Epidural; Anesthetics, Local; Anti-Inflammatory Agents; Bupivacaine; Case-Co | 2020 |
[Epidural injection shows no advantages over oral medication and physiotherapy in the treatment of sciatica, irrespective of the duration of symptoms].
Topics: Administration, Oral; Analgesics; Anesthetics, Local; Bupivacaine; Female; Humans; Injections, Epidu | 2014 |
CT-guided piriformis muscle injection for the treatment of piriformis syndrome.
Topics: Adult; Aged; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Bupivacaine; Electromyogra | 2014 |
CT-guided infiltration saves surgical intervention and fastens return to work compared to anatomical landmark-guided infiltration in patients with lumbosciatica.
Topics: Adult; Analgesics; Anatomic Landmarks; Anesthetics, Local; Anti-Inflammatory Agents; Bupivacaine; Fe | 2015 |
Re: Karppinen J. et al. Periradicular infiltration for sciatica. A randomized controlled trial. Spine 26, 1059-1067:2001.
Topics: Anesthetics, Local; Bupivacaine; Drug Combinations; Glucocorticoids; Humans; Injections; Methylpredn | 2002 |
Piriformis syndrome: Correlation of muscle morphology with symptoms and signs.
Topics: Anesthetics, Local; Bupivacaine; Buttocks; Female; Humans; Low Back Pain; Male; Middle Aged; Muscle, | 2004 |
Sciatica of nondisc origin and piriformis syndrome: diagnosis by magnetic resonance neurography and interventional magnetic resonance imaging with outcome study of resulting treatment.
Topics: Adult; Aged; Back; Bupivacaine; Diagnosis, Differential; Follow-Up Studies; Humans; Image Enhancemen | 2005 |
Interlaminar epidural corticosteroid injection in the treatment of lumbosciatic pain: a retrospective analysis.
Topics: Adult; Aged; Aged, 80 and over; Anesthetics, Local; Bupivacaine; Drug Therapy, Combination; Female; | 2007 |
Systemic side-effects of extradural steroids.
Topics: Anesthesia, Epidural; Bupivacaine; Female; Humans; Male; Methylprednisolone; Sciatica | 1980 |
[Delayed low back pain after spinal anesthesia].
Topics: Anesthesia, Spinal; Anesthetics, Local; Bupivacaine; Hernia, Inguinal; Humans; Low Back Pain; Magnet | 1995 |
When all else fails: stepwise multiple solutions for a complex cancer pain syndrome.
Topics: Aged; Analgesics; Analgesics, Opioid; Anesthetics, Local; Bupivacaine; Cholinesterase Inhibitors; Cl | 1999 |
Operative repair of symptomatic spondylolysis following a positive response to diagnostic pars injection.
Topics: Adolescent; Adult; Anesthetics, Local; Back Pain; Bupivacaine; Female; Humans; Injections, Spinal; L | 1999 |
[A case of Guillain-Barrè syndrome with severe sciatica preceding motor paralysis in the lower extremities].
Topics: Analgesia, Epidural; Analgesia, Patient-Controlled; Anesthetics, Local; Bupivacaine; Humans; Leg; Ma | 1999 |
Periradicular infiltration for sciatica.
Topics: Bupivacaine; Humans; Injections, Epidural; Methylprednisolone; Randomized Controlled Trials as Topic | 2002 |
Treatment of low back pain and sciatica with extradural analgesia and steroid injection 1971-1978.
Topics: Adult; Anesthesia, Epidural; Back Pain; Bupivacaine; Dexamethasone; Epinephrine; Female; Humans; Mal | 1979 |
[Continuous self-administered epidural methadone and Marcaine for low-back and sciatic pain].
Topics: Anesthesia, Epidural; Back Pain; Bupivacaine; Humans; Infusion Pumps; Methadone; Sciatica; Self Admi | 1987 |
Prolonged extradural anaesthesia with bupivacaine at lumbago and sciatica.
Topics: Adult; Aged; Anesthesia, Epidural; Anesthetics, Local; Autonomic Nerve Block; Back Pain; Blood Press | 1971 |