bupivacaine and Rib Fractures

bupivacaine has been researched along with Rib Fractures in 27 studies

Bupivacaine: A widely used local anesthetic agent.
1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide : A piperidinecarboxamide obtained by formal condensation of the carboxy group of N-butylpipecolic acid with the amino group of 2,6-dimethylaniline.
bupivacaine : A racemate composed of equimolar amounts of dextrobupivacaine and levobupivacaine. Used (in the form of its hydrochloride hydrate) as a local anaesthetic.

Rib Fractures: Fractures of any of the RIBS.

Research

Studies (27)

Authors

Clinical Trials (8)

Trial Overview

Trial Outcomes

Development of Pneumonia

Development of pneumonia defined as >100,000 colony forming units/milliliter bacteria on bronchoalveolar lavage or clinically with leukocytosis, pulmonary infiltrate and fever with 96 hours post-randomization. (NCT02749968)
Timeframe: 96 hours following randomization

Opioid Requirement at 24 Hours Post-randomization

Opioid requirement (in morphine equivalents) at 24 hours post-randomization (NCT02749968)
Timeframe: 24 hours following randomization.

Opioid Requirement at 48 Hours Post-randomization.

Opioid requirement (in morphine equivalents) at 48 hours post-randomization (NCT02749968)
Timeframe: 48 hours following randomization.

Opioid Requirement at 72 Hours Post-randomization

Opioid requirement (in morphine equivalents) at 72 hours post-randomization (NCT02749968)
Timeframe: 72 hours following randomization.

Opioid Requirement at 96 Hours Post-randomization

Opioid requirement (in morphine equivalents) at 96 hours post-randomization (NCT02749968)
Timeframe: 96 hours following randomization.

Self-reported Pain at 96 Hours Post-randomization

Self-reported pain will be measured using the verbal NRS, a 0-10 ordinal scale. Pain assessments will be reported at 96 hours after enrollment, as this is the reported duration of effect for liposomal bupivacaine. Higher scores (10) indicate more pain, lower scores (0) indicate lower pain. (NCT02749968)
Timeframe: At 96 hours post-randomization

Daily Sequential Clinical Assessment of Respiratory Function (SCARF) Score

The SCARF score is a validated, dynamic tool that ranges from 0-4, with 0 being the best score and 4 being the worst. One point is given for each of the following four parameters: (1) respiratory rate ≥ 20 breaths per minute; (2) numeric pain score ≥ 5; (3) incentive spirometry < 50% of predicted based upon a nomogram including sex, height, and age; (4) cough deemed inadequate to clear respiratory secretions by respiratory therapists. The parameters used to calculate the SCARF score are summed to create the total 0-4 score and these results were recorded by clinical personnel not involved in the trial. SCARF scores were taken at 10 am daily for all postoperative inpatient hospital days, however due to variance in length of stay, only scores from the first 5 postoperative days were recorded for the purpose of this results analysis. Scores were then aggregated across the patients and timeframe to result in one median score per group. (NCT03305666)
Timeframe: Median SCARF scores were recorded for the first 5 postoperative days.

Percentage of Participants Experiencing Failure of Primary Loco-Regional Analgesia (LRA)

The failure of LRA for this study was defined as the percentage number of instances a patient required a secondary LRA modality within 72 hours of placement of the primary modality for either treatment arm. Requirement of this secondary LRA was determined by the patients' medical team with criteria based on subjective patient experience of pain. (NCT03305666)
Timeframe: 72 hours

Daily Narcotic Requirements Using Equi-analgesic Doses

Narcotic pain medication requirements were recorded daily over the duration of inpatient hospital stay, however due to variance in length of stay, only the first 5 postoperative days were recorded for this analysis. Scores were averaged across patients providing one daily postoperative mean score per treatment group. The narcotics provided to patients varied based on standard of care, so an Equi-Analgesic Scale was used to standardize dosages across narcotic type. A 1:1 ratio for narcotic dosages is calculated with the following measured as equivalent: 1.5 milligrams (mg) of intravenous (IV) Hydromorphone; 7.5 mg of per oral (PO) Hydromorphone; 100 micrograms (mcg) of IV Fentanyl; 10 mg of IV Morphine; 30 mg of PO Morphine; 20 mg of PO Oxycodone (Percocet); and 30 mg of PO Hydrocodone (Vicodin). In the context of this scale, lower scores are best, indicating fewer narcotics required and higher scores are worse indicating the need for more narcotics based on subjective patient pain. (NCT03305666)
Timeframe: Mean narcotic requirement scores were recorded for the first 5 postoperative hospital inpatient days.

Reviews

1 review available for bupivacaine and Rib Fractures

Trials

3 trials available for bupivacaine and Rib Fractures

Other Studies

24 other studies available for bupivacaine and Rib Fractures