bupivacaine has been researched along with Peripheral Nervous System Diseases in 23 studies
Bupivacaine: A widely used local anesthetic agent.
1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide : A piperidinecarboxamide obtained by formal condensation of the carboxy group of N-butylpipecolic acid with the amino group of 2,6-dimethylaniline.
bupivacaine : A racemate composed of equimolar amounts of dextrobupivacaine and levobupivacaine. Used (in the form of its hydrochloride hydrate) as a local anaesthetic.
Peripheral Nervous System Diseases: Diseases of the peripheral nerves external to the brain and spinal cord, which includes diseases of the nerve roots, ganglia, plexi, autonomic nerves, sensory nerves, and motor nerves.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Eligible patients with radicular pain who had unilateral symptoms who failed conservative management were randomized for a single injection with bupivacaine and methylprednisolone or bupivacaine only." | 5.11 | The efficacy of corticosteroids in periradicular infiltration for chronic radicular pain: a randomized, double-blind, controlled trial. ( Chaudhary, N; Ng, L; Sell, P, 2005) |
| "Our previous experiments demonstrated that systemic treatment with GM1 ganglioside reduces nociceptive behaviors and spinal cord metabolic activity in a rat model of painful peripheral mononeuropathy produced by experimental sciatic nerve ligation (chronic constrictive injury, CCI)." | 3.68 | Intrathecal GM1 ganglioside and local nerve anesthesia reduce nociceptive behaviors in rats with experimental peripheral mononeuropathy. ( Hayes, RL; Lu, J; Mao, J; Mayer, DJ; Price, DD, 1992) |
| "Water intoxication was performed in a standard way by fractionated hyperhydration." | 1.46 | Study of locomotion, rearing and grooming activity after single and/or concomitant lesions of central and peripheral nervous system in rats. ( Kozler, P; Maresova, D; Pokorny, J, 2017) |
| "The resulting hyperalgesia to radiant heat and spontaneous nociceptive behaviors was assessed by using a foot-withdrawal test and a spontaneous pain behavior rating method, respectively." | 1.28 | Intrathecal MK-801 and local nerve anesthesia synergistically reduce nociceptive behaviors in rats with experimental peripheral mononeuropathy. ( Hayes, RL; Lu, J; Mao, J; Mayer, DJ; Price, DD, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (13.04) | 18.7374 |
| 1990's | 11 (47.83) | 18.2507 |
| 2000's | 6 (26.09) | 29.6817 |
| 2010's | 3 (13.04) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kozler, P | 1 |
| Maresova, D | 1 |
| Pokorny, J | 1 |
| Xie, W | 1 |
| Strong, JA | 1 |
| Zhang, JM | 1 |
| Scuderi, GJ | 1 |
| Cuellar, JM | 1 |
| Cuellar, VG | 1 |
| Yeomans, DC | 1 |
| Carragee, EJ | 1 |
| Angst, MS | 1 |
| Takasu, M | 1 |
| Okita, M | 1 |
| Araki, T | 1 |
| Tanitame, N | 1 |
| Tamura, A | 1 |
| Suwaki, N | 1 |
| Ito, K | 1 |
| Keidan, I | 1 |
| Ben-Menachem, E | 1 |
| Ben-Menchem, E | 1 |
| Ng, L | 1 |
| Chaudhary, N | 1 |
| Sell, P | 1 |
| Vignaud, A | 1 |
| Hourdé, C | 1 |
| Butler-Browne, G | 1 |
| Ferry, A | 1 |
| Eipe, N | 1 |
| McCartney, CJ | 1 |
| Kummer, C | 1 |
| Carpenter, RL | 1 |
| Hampl, KF | 1 |
| Schneider, MC | 1 |
| Ummenhofer, W | 1 |
| Drewe, J | 1 |
| Derrick, JL | 1 |
| Aun, CS | 1 |
| Myers, KG | 1 |
| George, RJ | 1 |
| Iaquinto, JM | 1 |
| Pienkowski, D | 1 |
| Thornsberry, R | 1 |
| Grant, S | 1 |
| Stevens, DB | 1 |
| Crawford, RW | 1 |
| Gie, GA | 1 |
| Ling, RS | 1 |
| Murray, DW | 1 |
| Tsen, LC | 1 |
| Cherayil, G | 1 |
| Witt, MA | 1 |
| Meaney, JT | 1 |
| Lipshultz, LI | 1 |
| Collier, CB | 1 |
| Kowalski, SE | 1 |
| Bradley, BD | 1 |
| Greengrass, RA | 1 |
| Freedman, J | 1 |
| Younes, MK | 1 |
| Mao, J | 2 |
| Price, DD | 2 |
| Mayer, DJ | 2 |
| Lu, J | 2 |
| Hayes, RL | 2 |
| Nyström, A | 1 |
| Lindström, G | 1 |
| Reiz, S | 1 |
| Hanel, DP | 1 |
| Benzon, HT | 1 |
| Bogduk, N | 1 |
| Marsland, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Using Inflammatory Biomarkers and EMG Results to Predict Epidural Injection Response in Patients Diagnosed With Lumbar Stenosis[NCT03511053] | 11 participants (Actual) | Interventional | 2017-12-19 | Completed | |||
| Do Cervical Interlaminar Epidural Steroid Injections With Low-dose Lidocaine Cause Transient Objective Upper Extremity Weakness? A Prospective Randomized[NCT03382925] | Phase 4 | 16 participants (Actual) | Interventional | 2017-12-20 | Terminated (stopped due to Not enough cervical interlaminar patients who meet criteria in order to meet recruitment goals.) | ||
| Lidocaine With Epinephrine vs. Bupivacaine With Epinephrine as Local Anesthetic Agents in Wide-awake Hand Surgery: an Outcome Study of Patients' Pain Perception.[NCT02315573] | 61 participants (Actual) | Interventional | 2014-10-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Measures how pain is affecting the patients lifestyle on a scale from 0 to 10 as defined by each question. The questionnaire contains 15 questions that each range on a scale form 0 to 10. The total score of the questionnaire ranges from 0 to 150. Lower values represent a better outcome. (NCT03511053)
Timeframe: Change between baseline, 1 month and 2 months post injection
| Intervention | score on a scale (Mean) | ||||
|---|---|---|---|---|---|
| Average at baseline | Average at 1 month | Average at 2 months | Average at 1 month change | Average at 2 month change | |
| All Participants | 77.5 | 53.3 | 64.3 | 27.3 | 16.2 |
Measures how pain due to spinal stenosis is effected the patient based on quality of life/pain questions and satisfaction questions for months 1 and 2 (no scales are used) SSSQ scores are reported in percentages 0-100%, higher scores indicate worse outcomes. (NCT03511053)
Timeframe: Change between baseline, 1 month and 2 months post injection
| Intervention | Percentage (Mean) | ||||
|---|---|---|---|---|---|
| Average at baseline | Average at 1 month | Average at 2 months | Average at 1 month change | Average at 2 month change | |
| All Participants | 64.1 | 53.2 | 53.5 | 11.7 | 10.3 |
Number rating of back/leg pain from 0 to 10, 0 being no pain/discomfort, 10 being extreme pain/discomfort (NCT03511053)
Timeframe: Change between baseline, 1 month and 2 months post injection
| Intervention | score on a scale (Mean) | ||||
|---|---|---|---|---|---|
| Average at baseline | Average at 1 month | Average at 2 months | Average 1 month change | Average 2 month change | |
| All Participants | 6.2 | 5.0 | 5.0 | 0.8 | 1 |
3 reviews available for bupivacaine and Peripheral Nervous System Diseases
| Article | Year |
|---|---|
Gadolinium enhancement of cauda equina after combined spinal-epidural anaesthesia.
Topics: Adult; Anesthesia, Epidural; Anesthesia, Spinal; Anesthetics, Local; Bupivacaine; Cesarean Section; | 2010 |
Accidental subdural block: four more cases and a radiographic review.
Topics: Adult; Analgesia, Epidural; Analgesia, Obstetrical; Bupivacaine; Cranial Nerve Diseases; Female; Hum | 1992 |
Epidural steroid injections for low back pain and lumbosacral radiculopathy.
Topics: Anesthesia, Epidural; Back Pain; Bupivacaine; Clinical Trials as Topic; Epidural Space; Glucocortico | 1986 |
4 trials available for bupivacaine and Peripheral Nervous System Diseases
| Article | Year |
|---|---|
The efficacy of corticosteroids in periradicular infiltration for chronic radicular pain: a randomized, double-blind, controlled trial.
Topics: Adult; Anesthetics, Local; Back Pain; Bupivacaine; Chronic Disease; Disability Evaluation; Double-Bl | 2005 |
Transient neurologic symptoms after spinal anesthesia.
Topics: Adolescent; Adult; Aged; Anesthesia, Obstetrical; Anesthesia, Spinal; Anesthetics, Local; Bupivacain | 1995 |
Bupivacaine: a safe local anesthetic for wrist blocks.
Topics: Bupivacaine; Double-Blind Method; Hand; Humans; Lidocaine; Nerve Block; Peripheral Nervous System Di | 1989 |
Epidural steroid injections for low back pain and lumbosacral radiculopathy.
Topics: Anesthesia, Epidural; Back Pain; Bupivacaine; Clinical Trials as Topic; Epidural Space; Glucocortico | 1986 |
17 other studies available for bupivacaine and Peripheral Nervous System Diseases
| Article | Year |
|---|---|
Study of locomotion, rearing and grooming activity after single and/or concomitant lesions of central and peripheral nervous system in rats.
Topics: Animals; Behavior, Animal; Brain Edema; Bupivacaine; Grooming; Locomotion; Male; Motor Activity; Per | 2017 |
Early blockade of injured primary sensory afferents reduces glial cell activation in two rat neuropathic pain models.
Topics: Animals; Biomarkers; Bupivacaine; CD11b Antigen; Disease Models, Animal; Ganglia, Spinal; Glial Fibr | 2009 |
Epidural interferon gamma-immunoreactivity: a biomarker for lumbar nerve root irritation.
Topics: Adult; Aged; Biomarkers; Bupivacaine; Cohort Studies; Epidural Space; Female; Follow-Up Studies; Hum | 2009 |
Postoperative occipital nerve injury in a child.
Topics: Anesthetics, Local; Bupivacaine; Burns; Child; Cranial Nerve Injuries; Humans; Male; Methylprednisol | 2012 |
Differential recovery of neuromuscular function after nerve/muscle injury induced by crude venom from Notechis scutatus, cardiotoxin from Naja atra and bupivacaine treatments in mice.
Topics: Analysis of Variance; Animals; Bupivacaine; Cobra Cardiotoxin Proteins; Elapid Venoms; Male; Mice; M | 2007 |
Transient neurological dysfunction after continuous femoral nerve block: should this change our practice?
Topics: Anesthetics, Local; Bupivacaine; Femoral Nerve; Humans; Nerve Block; Peripheral Nervous System Disea | 2007 |
Hyperbaric lidocaine spinal anesthesia: do we need an alternative?
Topics: Anesthesia, Spinal; Anesthetics, Local; Bupivacaine; Drug Monitoring; Humans; Lidocaine; Pain; Perip | 1995 |
Transient femoral nerve palsy after ilioinguinal block.
Topics: Bupivacaine; Child; Femoral Nerve; Humans; Male; Nerve Block; Paralysis; Peripheral Nervous System D | 1996 |
Painful neuropathy of the lateral cutaneous nerve of the thigh in patients with AIDS: successful treatment by injection with bupivacaine and triamcinolone.
Topics: Acquired Immunodeficiency Syndrome; Adult; Analgesics; Bupivacaine; Female; Humans; Pain; Peripheral | 1996 |
Increased neurologic complications associated with postoperative epidural analgesia after tibial fracture fixation.
Topics: Adult; Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthetics, Local; B | 1997 |
Diagnostic value of intra-articular anaesthetic in primary osteoarthritis of the hip.
Topics: Anesthetics, Local; Arthroplasty, Replacement, Hip; Bupivacaine; Female; Follow-Up Studies; Hip Join | 1998 |
Sickle cell-induced peripheral neuropathy following spinal anesthesia for cesarean delivery.
Topics: Adult; Anemia, Sickle Cell; Anesthesia, Obstetrical; Anesthesia, Spinal; Bupivacaine; Cesarean Secti | 2001 |
Accidental femoral nerve block following administration of local anesthetic for varicocele repair.
Topics: Adult; Anesthesia, Local; Bupivacaine; Femoral Nerve; Humans; Male; Nerve Block; Pain, Postoperative | 1992 |
Effects of interpleural bupivacaine (0.5%) on canine diaphragmatic function.
Topics: Animals; Bupivacaine; Diaphragm; Dogs; Injections; Peripheral Nervous System Diseases; Phrenic Nerve | 1992 |
Intrathecal MK-801 and local nerve anesthesia synergistically reduce nociceptive behaviors in rats with experimental peripheral mononeuropathy.
Topics: Anesthesia, Local; Animals; Bupivacaine; Disease Models, Animal; Dizocilpine Maleate; Drug Synergism | 1992 |
Intrathecal GM1 ganglioside and local nerve anesthesia reduce nociceptive behaviors in rats with experimental peripheral mononeuropathy.
Topics: Anesthesia, Local; Animals; Behavior, Animal; Bupivacaine; G(M1) Ganglioside; Injections, Spinal; Ma | 1992 |
On the concept of third occipital headache.
Topics: Adult; Axis, Cervical Vertebra; Bupivacaine; Cervical Vertebrae; Female; Headache; Humans; Male; Mid | 1986 |