Page last updated: 2024-10-24

bupivacaine and Pancreatitis

bupivacaine has been researched along with Pancreatitis in 20 studies

Bupivacaine: A widely used local anesthetic agent.
1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide : A piperidinecarboxamide obtained by formal condensation of the carboxy group of N-butylpipecolic acid with the amino group of 2,6-dimethylaniline.
bupivacaine : A racemate composed of equimolar amounts of dextrobupivacaine and levobupivacaine. Used (in the form of its hydrochloride hydrate) as a local anaesthetic.

Pancreatitis: INFLAMMATION of the PANCREAS. Pancreatitis is classified as acute unless there are computed tomographic or endoscopic retrograde cholangiopancreatographic findings of CHRONIC PANCREATITIS (International Symposium on Acute Pancreatitis, Atlanta, 1992). The two most common forms of acute pancreatitis are ALCOHOLIC PANCREATITIS and gallstone pancreatitis.

Research Excerpts

ExcerptRelevanceReference
"A case of long-term relief of pain after interpleural blockade with bupivacaine in a patient suffering from severe chronic pancreatitis is reported."7.67[Interpleural bupivacaine (Marcain) in the treatment of pain in a patient with chronic pancreatitis]. ( Ahlburg, P; Mølgaard, J; Noreng, MF, 1989)
"A case of long-term relief of pain after interpleural blockade with bupivacaine in a patient suffering from severe chronic pancreatitis is reported."3.67[Interpleural bupivacaine (Marcain) in the treatment of pain in a patient with chronic pancreatitis]. ( Ahlburg, P; Mølgaard, J; Noreng, MF, 1989)
"BACKGROUND Acute pancreatitis is the leading gastrointestinal cause of hospitalization in the United States."1.62Localizing the Pain: Continuous Paravertebral Nerve Blockade in a Patient with Acute Pancreatitis. ( Cammarano, CA; Sandhu, NS; Villaluz, JE, 2021)
"We report on a patient with acute pancreatitis whose pain was resistant to simultaneous administration of morphine, procaine and Buscopan."1.28[The value of epidural analgesia in acute pancreatitis]. ( Borgeat, A; Chanson, C; Nicolet, A; Schwander, D, 1990)

Research

Studies (20)

TimeframeStudies, this research(%)All Research%
pre-19902 (10.00)18.7374
1990's10 (50.00)18.2507
2000's4 (20.00)29.6817
2010's2 (10.00)24.3611
2020's2 (10.00)2.80

Authors

AuthorsStudies
Cammarano, CA1
Sandhu, NS1
Villaluz, JE1
González Martínez, S1
Gómez Facundo, H1
Deiros García, C1
Pueyo Periz, EM1
Ribas Montoliu, R1
Coronado Llanos, D1
Masdeu Castellvi, J1
Martin-Baranera, M1
Freitag, FA1
Bozak, VL1
do Carmo, MP1
Froes, TR1
Duque, JC1
Sadowski, SM1
Andres, A1
Morel, P1
Schiffer, E1
Frossard, JL1
Platon, A1
Poletti, PA1
Bühler, L1
LeBlanc, JK1
DeWitt, J1
Johnson, C1
Okumu, W1
McGreevy, K1
Symms, M1
McHenry, L1
Sherman, S3
Imperiale, T1
Chan, VW1
Faigel, DO1
Veloso, KM1
Long, WB1
Kochman, ML1
Verheijen, R1
Slappendel, R1
Jansen, JB1
Crul, BJ1
van Dongen, RT1
Mäkelä, A1
Kuusi, T1
Schröder, T1
Gress, F2
Schmitt, C2
Ikenberry, S2
Lehman, G2
Pirágine, M1
Mele, E1
Caramutti, D1
Justo, JR1
Carels, RA1
Ponssen, HH1
van Vliet, AC1
Hol, PK1
Kvarstein, G1
Viken, O1
Smedby, O1
Tønnessen, TI1
Ciaccia, D1
Stavas, J1
Niesel, HC1
Klimpel, L1
Kaiser, H1
Bernhardt, A1
al-Rafai, S1
Lang, U1
Borgeat, A1
Nicolet, A1
Chanson, C1
Schwander, D1
Ahlburg, P2
Noreng, M1
Mølgaard, J2
Egebo, K1
Noreng, MF2
Christensen, PA1
Thiessen, B1

Clinical Trials (5)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Single Center, Randomized, Double-Blind Controlled Study of Topical Endoluminal Pancreatic Duct Lidocaine for Prevention of Post-ERCP Pancreatitis[NCT00953199]506 participants (Actual)Interventional2010-03-31Completed
A Randomized Controlled Trial of IV Ketorolac to Prevent Post-ERCP Pancreatitis[NCT02465138]Phase 40 participants (Actual)Interventional2023-11-30Withdrawn (stopped due to Lack of Funding)
Effects of High Intra-procedural Oxygen Fraction on Post-ERCP Pancreatitis: A Randomized Clinical Trial[NCT04876768]25 participants (Actual)Interventional2021-05-18Completed
Paragastric Lesser Omentum Neural Block to Prevent Visceral Pain After Laparoscopic Sleeve Gastrectomy: A Randomized Clinical Trial Protocol.[NCT05353426]145 participants (Actual)Interventional2021-08-13Completed
Prospective Randomized Trial of EUS Guided Celiac Plexus Block for Chronic Pancreatitis[NCT02399800]1 participants (Actual)Interventional2014-12-31Terminated (stopped due to Low enrollment)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Post ERCP Pancreatitis is the Primary Outcome.

The primary outcome of interest will be development of acute pancreatitis defined as new or worsening abdominal pain post-ERCP associated with an increase in serum amylase at least 3 times the upper limit of normal. (NCT00953199)
Timeframe: 24-48 hours post-procedure

Interventionparticipants (Number)
Lidocaine26
Normal Saline20

Serum Amylase Levels

serum amylase levels are measure by a blood draw (NCT00953199)
Timeframe: measurement is taken 2 hrs after ERCP

Interventionunits/liter (Mean)
Lidocaine130
Normal Saline128

Trials

3 trials available for bupivacaine and Pancreatitis

ArticleYear
Epidural anesthesia improves pancreatic perfusion and decreases the severity of acute pancreatitis.
    World journal of gastroenterology, 2015, Nov-21, Volume: 21, Issue:43

    Topics: Abdominal Pain; Acute Disease; Aged; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthesia,

2015
A prospective randomized trial of 1 versus 2 injections during EUS-guided celiac plexus block for chronic pancreatitis pain.
    Gastrointestinal endoscopy, 2009, Volume: 69, Issue:4

    Topics: Adult; Aged; Anesthetics, Local; Bupivacaine; Celiac Plexus; Chronic Disease; Endosonography; Female

2009
A prospective randomized comparison of endoscopic ultrasound- and computed tomography-guided celiac plexus block for managing chronic pancreatitis pain.
    The American journal of gastroenterology, 1999, Volume: 94, Issue:4

    Topics: Abdominal Pain; Anesthetics, Local; Autonomic Nerve Block; Bupivacaine; Celiac Plexus; Chronic Disea

1999
A prospective randomized comparison of endoscopic ultrasound- and computed tomography-guided celiac plexus block for managing chronic pancreatitis pain.
    The American journal of gastroenterology, 1999, Volume: 94, Issue:4

    Topics: Abdominal Pain; Anesthetics, Local; Autonomic Nerve Block; Bupivacaine; Celiac Plexus; Chronic Disea

1999
A prospective randomized comparison of endoscopic ultrasound- and computed tomography-guided celiac plexus block for managing chronic pancreatitis pain.
    The American journal of gastroenterology, 1999, Volume: 94, Issue:4

    Topics: Abdominal Pain; Anesthetics, Local; Autonomic Nerve Block; Bupivacaine; Celiac Plexus; Chronic Disea

1999
A prospective randomized comparison of endoscopic ultrasound- and computed tomography-guided celiac plexus block for managing chronic pancreatitis pain.
    The American journal of gastroenterology, 1999, Volume: 94, Issue:4

    Topics: Abdominal Pain; Anesthetics, Local; Autonomic Nerve Block; Bupivacaine; Celiac Plexus; Chronic Disea

1999

Other Studies

17 other studies available for bupivacaine and Pancreatitis

ArticleYear
Localizing the Pain: Continuous Paravertebral Nerve Blockade in a Patient with Acute Pancreatitis.
    The American journal of case reports, 2021, Dec-27, Volume: 22

    Topics: Acute Disease; Adult; Bupivacaine; Female; Humans; Nerve Block; Pain, Postoperative; Pancreatitis

2021
Transversus abdominis plane block in acute pancreatitis pain management.
    Gastroenterologia y hepatologia, 2021, Volume: 44, Issue:2

    Topics: Abdominal Muscles; Acute Disease; Bupivacaine; Humans; Mepivacaine; Nerve Block; Pain; Pain Manageme

2021
Continuous transversus abdominis plane block for analgesia in three dogs with abdominal pain.
    Veterinary anaesthesia and analgesia, 2018, Volume: 45, Issue:4

    Topics: Abdominal Muscles; Abdominal Pain; Anesthetics, Local; Animals; Bupivacaine; Dog Diseases; Dogs; Mal

2018
Chronic diarrhea: an uncommon side effect of celiac plexus block.
    Anesthesia and analgesia, 1996, Volume: 82, Issue:1

    Topics: Autonomic Nerve Block; Bupivacaine; Celiac Plexus; Chronic Disease; Diarrhea; Ethanol; Female; Human

1996
Endosonography-guided celiac plexus injection for abdominal pain due to chronic pancreatitis.
    The American journal of gastroenterology, 1996, Volume: 91, Issue:8

    Topics: Abdominal Pain; Adult; Anesthetics, Local; Autonomic Nerve Block; Bupivacaine; Celiac Plexus; Chroni

1996
[Intrathecal administration of morphine and bupivacaine in the treatment of severe pain in chronic pancreatitis].
    Nederlands tijdschrift voor geneeskunde, 1996, Jul-06, Volume: 140, Issue:27

    Topics: Adult; Analgesics, Opioid; Anesthetics, Local; Bupivacaine; Chronic Disease; Humans; Infusion Pumps;

1996
Inhibition of serum phospholipase-A2 in acute pancreatitis by pharmacological agents in vitro.
    Scandinavian journal of clinical and laboratory investigation, 1997, Volume: 57, Issue:5

    Topics: Acute Disease; Adrenergic beta-Antagonists; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Ste

1997
Inhibition of serum phospholipase-A2 in acute pancreatitis by pharmacological agents in vitro.
    Scandinavian journal of clinical and laboratory investigation, 1997, Volume: 57, Issue:5

    Topics: Acute Disease; Adrenergic beta-Antagonists; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Ste

1997
Inhibition of serum phospholipase-A2 in acute pancreatitis by pharmacological agents in vitro.
    Scandinavian journal of clinical and laboratory investigation, 1997, Volume: 57, Issue:5

    Topics: Acute Disease; Adrenergic beta-Antagonists; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Ste

1997
Inhibition of serum phospholipase-A2 in acute pancreatitis by pharmacological agents in vitro.
    Scandinavian journal of clinical and laboratory investigation, 1997, Volume: 57, Issue:5

    Topics: Acute Disease; Adrenergic beta-Antagonists; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Ste

1997
Inhibition of serum phospholipase-A2 in acute pancreatitis by pharmacological agents in vitro.
    Scandinavian journal of clinical and laboratory investigation, 1997, Volume: 57, Issue:5

    Topics: Acute Disease; Adrenergic beta-Antagonists; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Ste

1997
Inhibition of serum phospholipase-A2 in acute pancreatitis by pharmacological agents in vitro.
    Scandinavian journal of clinical and laboratory investigation, 1997, Volume: 57, Issue:5

    Topics: Acute Disease; Adrenergic beta-Antagonists; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Ste

1997
Inhibition of serum phospholipase-A2 in acute pancreatitis by pharmacological agents in vitro.
    Scandinavian journal of clinical and laboratory investigation, 1997, Volume: 57, Issue:5

    Topics: Acute Disease; Adrenergic beta-Antagonists; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Ste

1997
Inhibition of serum phospholipase-A2 in acute pancreatitis by pharmacological agents in vitro.
    Scandinavian journal of clinical and laboratory investigation, 1997, Volume: 57, Issue:5

    Topics: Acute Disease; Adrenergic beta-Antagonists; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Ste

1997
Inhibition of serum phospholipase-A2 in acute pancreatitis by pharmacological agents in vitro.
    Scandinavian journal of clinical and laboratory investigation, 1997, Volume: 57, Issue:5

    Topics: Acute Disease; Adrenergic beta-Antagonists; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Ste

1997
[Moderating action of celiac block in experimental pancreatitis in the dog].
    Acta gastroenterologica Latinoamericana, 1999, Volume: 29, Issue:5

    Topics: Acute Disease; Anesthetics, Local; Animals; Autonomic Nerve Block; Bupivacaine; Celiac Plexus; Disea

1999
[Meperidine (pethidine) outdated as analgesic in acute pancreatitis].
    Nederlands tijdschrift voor geneeskunde, 2000, Sep-16, Volume: 144, Issue:38

    Topics: Acute Disease; Analgesics, Opioid; Anesthetics, Local; Bupivacaine; Contraindications; Drug Therapy,

2000
MRI-guided celiac plexus block.
    Journal of magnetic resonance imaging : JMRI, 2000, Volume: 12, Issue:4

    Topics: Abdominal Pain; Autonomic Nerve Block; Bupivacaine; Celiac Plexus; Chronic Disease; Female; Humans;

2000
Endoscopic ultrasound-guided celiac plexus block for managing abdominal pain associated with chronic pancreatitis: a prospective single center experience.
    The American journal of gastroenterology, 2001, Volume: 96, Issue:2

    Topics: Abdominal Pain; Autonomic Nerve Block; Bupivacaine; Celiac Plexus; Chronic Disease; Costs and Cost A

2001
Celiac ganglion block: CT guidance.
    The Nebraska medical journal, 1990, Volume: 75, Issue:2

    Topics: Adult; Autonomic Nerve Block; Bupivacaine; Ganglia, Sympathetic; Humans; Male; Pain; Pain Management

1990
[Epidural blockade for analgesia and treatment of acute pancreatitis].
    Regional-Anaesthesie, 1991, Volume: 14, Issue:6

    Topics: Acute Disease; Adult; Aged; Aged, 80 and over; Analgesia, Epidural; Bupivacaine; Cholangiopancreatog

1991
[The value of epidural analgesia in acute pancreatitis].
    Schweizerische medizinische Wochenschrift, 1990, Feb-03, Volume: 120, Issue:5

    Topics: Analgesia, Epidural; Bupivacaine; Cardiovascular Diseases; Drug Therapy, Combination; Fentanyl; Huma

1990
Treatment of pancreatic pain with interpleural bupivacaine: an open trial.
    Acta anaesthesiologica Scandinavica, 1990, Volume: 34, Issue:2

    Topics: Adult; Bupivacaine; Catheters, Indwelling; Chronic Disease; Female; Humans; Male; Middle Aged; Pain;

1990
[Interpleural bupivacaine (Marcain) in the treatment of pain in a patient with chronic pancreatitis].
    Ugeskrift for laeger, 1989, Nov-20, Volume: 151, Issue:47

    Topics: Adult; Anesthetics, Local; Bupivacaine; Chronic Disease; Humans; Male; Nerve Block; Pancreatitis; Pl

1989
[Acute pancreatitis. Treatment with continuous infusion of marcaine].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1987, Sep-20, Volume: 107, Issue:26

    Topics: Acute Disease; Adult; Anesthesia, Epidural; Bupivacaine; Humans; Male; Pain; Pancreatitis

1987