bupivacaine has been researched along with Osteoarthritis, Knee in 25 studies
Bupivacaine: A widely used local anesthetic agent.
1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide : A piperidinecarboxamide obtained by formal condensation of the carboxy group of N-butylpipecolic acid with the amino group of 2,6-dimethylaniline.
bupivacaine : A racemate composed of equimolar amounts of dextrobupivacaine and levobupivacaine. Used (in the form of its hydrochloride hydrate) as a local anaesthetic.
Osteoarthritis, Knee: Noninflammatory degenerative disease of the knee joint consisting of three large categories: conditions that block normal synchronous movement, conditions that produce abnormal pathways of motion, and conditions that cause stress concentration resulting in changes to articular cartilage. (Crenshaw, Campbell's Operative Orthopaedics, 8th ed, p2019)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pain is the main symptom of osteoarthritis (OA) with approximately 50% of patients reporting moderate-to-severe pain." | 7.30 | Is there a difference in the analgesic response to intra-articular bupivacaine injection in people with knee osteoarthritis pain with or without central sensitisation? Protocol of a feasibility randomised controlled trial. ( Auer, DP; Cooper, D; Knaggs, R; Kurien, T; Scammell, BE; Walsh, DA; Zedan, Y, 2023) |
| "Significant pain reduction was achieved one hour post-bupivacaine (mean difference as a percentage change 56." | 5.10 | Effect of pain reduction on postural sway, proprioception, and quadriceps strength in subjects with knee osteoarthritis. ( Doherty, M; Doherty, SA; Hassan, BS; Mockett, S, 2002) |
| "Pain is the main symptom of osteoarthritis (OA) with approximately 50% of patients reporting moderate-to-severe pain." | 3.30 | Is there a difference in the analgesic response to intra-articular bupivacaine injection in people with knee osteoarthritis pain with or without central sensitisation? Protocol of a feasibility randomised controlled trial. ( Auer, DP; Cooper, D; Knaggs, R; Kurien, T; Scammell, BE; Walsh, DA; Zedan, Y, 2023) |
| "The outcome parameters were postoperative pain assessed by using a visual analog scale (VAS), the maximal angle of knee flexion, and quadriceps function from day 1 to 6 weeks after surgery." | 2.90 | Timing of periarticular injection has no effect on postoperative pain and functional recovery in simultaneous bilateral total knee arthroplasty: a prospective randomized, double-blinded trial. ( Jarusriwanna, A; Laoruengthana, A; Pongpirul, K; Rasamimongkol, S; Rattanaprichavej, P; Varakornpipat, P, 2019) |
| "Postoperative pain is one of the issues that concern most patients after total knee arthroplasty (TKA)." | 2.87 | Periarticular multimodal drug injection is better than single anesthetic drug in controlling pain after total knee arthroplasty. ( Kanitnate, S; Manuwong, S; Panichkul, P; Tammachote, N, 2018) |
| " The dosage was 0." | 2.78 | Ropivacaine versus bupivacaine for 3-in-1 block during total knee arthroplasty. ( Chalidis, B; Goroszeniuk, T; Grosomanidis, V; Sachinis, N; Theodosiadis, P, 2013) |
| "Bupivacaine treatment led to an increase in Caspase 3 gene expression (P = 0." | 1.56 | Acetaminophen, bupivacaine, Duramorph, and Toradol: A comparison of chondrocyte viability and gene expression changes in osteoarthritic human chondrocytes. ( Chen, C; Cooke, C; Flynn, J; Jackson, N; Keating, P; Lemos, S; Markel, D; Osborne, J, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 7 (28.00) | 29.6817 |
| 2010's | 14 (56.00) | 24.3611 |
| 2020's | 4 (16.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zedan, Y | 1 |
| Knaggs, R | 1 |
| Cooper, D | 1 |
| Kurien, T | 1 |
| Walsh, DA | 1 |
| Auer, DP | 1 |
| Scammell, BE | 1 |
| Liu, M | 1 |
| Zhang, D | 1 |
| Shi, B | 1 |
| Knight, R | 1 |
| Poulton, L | 1 |
| Strickland, LH | 1 |
| Hamilton, TW | 1 |
| Beard, D | 1 |
| Cook, J | 1 |
| Dutton, SJ | 1 |
| Leal, J | 1 |
| Lamb, S | 1 |
| Cooper, C | 1 |
| Barker, KL | 1 |
| Murray, DW | 2 |
| Pandit, HG | 1 |
| Altay, N | 1 |
| Sarıkaya, B | 1 |
| Karahan, MA | 1 |
| Büyükfırat, E | 1 |
| Binici, O | 1 |
| Ertürk, C | 1 |
| Altay, MA | 1 |
| Cooke, C | 1 |
| Osborne, J | 1 |
| Jackson, N | 1 |
| Keating, P | 1 |
| Flynn, J | 1 |
| Markel, D | 1 |
| Chen, C | 1 |
| Lemos, S | 1 |
| Çay, N | 1 |
| Choi, JA | 1 |
| Gonzalez, FM | 1 |
| Markhardt, BK | 1 |
| Sutter, R | 1 |
| Tammachote, N | 1 |
| Kanitnate, S | 1 |
| Manuwong, S | 1 |
| Panichkul, P | 1 |
| Laoruengthana, A | 1 |
| Jarusriwanna, A | 1 |
| Rattanaprichavej, P | 1 |
| Rasamimongkol, S | 1 |
| Varakornpipat, P | 1 |
| Pongpirul, K | 1 |
| Theodosiadis, P | 1 |
| Sachinis, N | 1 |
| Goroszeniuk, T | 1 |
| Grosomanidis, V | 1 |
| Chalidis, B | 1 |
| Jung, WH | 1 |
| Takeuchi, R | 1 |
| Chun, CW | 1 |
| Lee, JS | 1 |
| Ha, JH | 1 |
| Kim, JH | 1 |
| Jeong, JH | 1 |
| Emerson, RH | 1 |
| Barrington, JW | 1 |
| Olugbode, O | 1 |
| Lovald, S | 1 |
| Watson, H | 1 |
| Ong, K | 1 |
| Iwasaki, K | 1 |
| Sudo, H | 1 |
| Kasahara, Y | 1 |
| Yamada, K | 1 |
| Ohnishi, T | 1 |
| Tsujimoto, T | 1 |
| Iwasaki, N | 1 |
| Sarı, S | 1 |
| Aydın, ON | 1 |
| Turan, Y | 1 |
| Özlülerden, P | 1 |
| Efe, U | 1 |
| Kurt Ömürlü, İ | 1 |
| Gazi, MB | 1 |
| Sakata, RK | 1 |
| Issy, AM | 1 |
| Fu, P | 1 |
| Wu, Y | 1 |
| Wu, H | 1 |
| Li, X | 1 |
| Qian, Q | 1 |
| Zhu, Y | 1 |
| Hay, DC | 1 |
| Mayle, RE | 1 |
| Goodman, SB | 1 |
| Mullaji, A | 1 |
| Kanna, R | 1 |
| Shetty, GM | 1 |
| Chavda, V | 1 |
| Singh, DP | 1 |
| Weston-Simons, JS | 1 |
| Pandit, H | 1 |
| Haliker, V | 1 |
| Dodd, CA | 1 |
| Popat, MT | 1 |
| Joo, JH | 1 |
| Park, JW | 1 |
| Kim, JS | 1 |
| Kim, YH | 1 |
| Lareau, JM | 1 |
| Robbins, CE | 1 |
| Talmo, CT | 1 |
| Mehio, AK | 1 |
| Puri, L | 1 |
| Bono, JV | 1 |
| Xie, Z | 1 |
| Hussain, W | 1 |
| Cutter, TW | 1 |
| Apfelbaum, JL | 1 |
| Drum, ML | 1 |
| Manning, DW | 1 |
| Karamanlioğlu, B | 1 |
| Alagöl, A | 1 |
| Turan, FN | 1 |
| Amin, N | 1 |
| Brancaccio, R | 1 |
| Cohen, D | 1 |
| DeWeese, FT | 1 |
| Akbari, Z | 1 |
| Carline, E | 1 |
| Hassan, BS | 1 |
| Doherty, SA | 1 |
| Mockett, S | 1 |
| Doherty, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Ultrasound Guided Sacroiliac Joint Injections With Ketorolac Versus Corticosteroid: A Prospective Non-inferiority Study[NCT06081101] | Early Phase 1 | 80 participants (Anticipated) | Interventional | 2024-01-31 | Not yet recruiting | ||
| Does Liposomal Bupivacaine Improve Postoperative Pain Control After One Level Posterior Spinal Fusion With Instrumentation[NCT03745040] | Phase 4 | 60 participants (Anticipated) | Interventional | 2019-01-26 | Recruiting | ||
| Comparative Feasibility and Efficacy of a Five Compartment Technique Using 0.25% Bupivacaine vs a Mixture of 0.25% Bupivacaine and 1.3 % Liposomal Bupivacaine in Patients Undergoing Tka; a Single Blinded Randomized Controlled Study[NCT03303794] | Phase 3 | 25 participants (Actual) | Interventional | 2017-10-25 | Terminated (stopped due to Interim Analysis showed no significance) | ||
| Comparison of the Effect of Intra-articular Administration of 2% Ropivacaine vs. 7.5% Ropivacaine as an Analgesic in the Immediate Postoperative Period of Knee Arthroscopy in Acute Injuries at the ABC Medical Center[NCT05807945] | Phase 4 | 68 participants (Actual) | Interventional | 2020-04-01 | Completed | ||
| Intra-Articular Morphine Versus Bupivacaine on Knee Motion in Patients With Osteoarthritis: Randomized and Double-Blind Clinical Trial[NCT00636415] | 30 participants (Actual) | Interventional | 2004-06-30 | Completed | |||
| A Double Blind Randomized Control Trial on the Efficacy of Periarticular Levo Bupivicaine Injection Following Primary Hip Arthroplasty[NCT01106001] | Phase 4 | 91 participants (Actual) | Interventional | 2008-09-30 | Completed | ||
| A Double Blind, Randomized Clinical Trial Comparing Postoperative Narcotic Usage in Patients Receiving Periarticular Liposomal Bupivicaine vs. Those Patients Receiving Standard Periarticular Joint Injections[NCT02682498] | Phase 4 | 38 participants (Actual) | Interventional | 2013-10-31 | Completed | ||
| Effects of Pre-emptive Scalp Infiltration With Ropivacaine and Methylprednisolone- Ropivacaine on Pain After Craniotomy in Adults[NCT04078139] | Phase 4 | 188 participants (Anticipated) | Interventional | 2021-03-05 | Not yet recruiting | ||
| Efficacy of Pain Management in Different Concentrations of Bupivacaine in Periarticular Injection and Plasma Concentrations of Bupivacaine in Patients Undergoing Bilateral Knee Arthroplasty[NCT03249662] | 60 participants (Actual) | Interventional | 2017-09-27 | Completed | |||
| Is There a Difference in the Analgesic Response to Intra-articular Bupivacaine Injection in People With Knee Osteoarthritis Pain With or Without Central Sensitisation?: a Feasibility Randomised Controlled Trial[NCT05561010] | 50 participants (Anticipated) | Interventional | 2022-10-31 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
AM-PAC (activity measure for post-acute care) will be used to determine if a patient is fit to discharge based on mobility with 6 being unable to mobilize up to 24 being independent. Patients who scored above 20 were considered fit to discharge. (NCT03303794)
Timeframe: Post-Operation Day 1
| Intervention | score on scale (Mean) |
|---|---|
| Bupivicaine | 23 |
| Bupivicaine + Exparel | 23 |
Monitor how much opioid patient consumes (NCT03303794)
Timeframe: During the first 48 hours after surgery
| Intervention | milligram (Mean) |
|---|---|
| Bupivicaine | 90 |
| Bupivicaine + Exparel | 76 |
Will use Numeric Pain Rating Scale (NPRS) to measure pain with 0 being no pain and 10 being the worst pain. (NCT03303794)
Timeframe: 48 hours postoperatively
| Intervention | score on scale (Mean) |
|---|---|
| Bupivicaine | 4 |
| Bupivicaine + Exparel | 4 |
A comparison of group means between the control group and study group with regards to 48 hour opioid use. (NCT02682498)
Timeframe: 48 hours
| Intervention | morphine equivalents (Mean) |
|---|---|
| EXPAREL® Bupivacaine Liposome Suspension | 5.32 |
| Standard Periarticular Joint Injection | 5.07 |
Opioid use will be monitored daily from the time of admission in comparison of standard knee injection post-operatively. (NCT02682498)
Timeframe: Up to 48 hours
| Intervention | Total Morphine Equivalents (Mean) |
|---|---|
| EXPAREL® Bupivacaine Liposome Suspension | 100 |
| Standard Periarticular Joint Injection | 103 |
Examining the average daily patient pain score in comparison of standard knee injection post-operatively. The measure is the Visual-Analog-Scale (VAS) for subjective pain reporting. The minimum 0 (no pain) and the maximum is 10 (worst pain imagineable). There is only one measure in the scale (i.e. there are no subscales). Lower scores on the VAS scale equate to less pain and are therefore desirable. (NCT02682498)
Timeframe: Up to 48 hours
| Intervention | Visual Analog Scale Rating (Mean) |
|---|---|
| EXPAREL® Bupivacaine Liposome Suspension | 4.75 |
| Standard Periarticular Joint Injection | 5.75 |
Examining the post-operative complication in comparison of standard knee injection post-operatively. (NCT02682498)
Timeframe: Up to 1 month
| Intervention | complications (Number) |
|---|---|
| EXPAREL® Bupivacaine Liposome Suspension | 0 |
| Standard Periarticular Joint Injection | 0 |
Post anesthesia care unit (recovery room) opioid use in total mg morphine IV equivalent in comparison of standard knee injection post-operatively. (NCT02682498)
Timeframe: Up to 48 hours
| Intervention | Total morphine equivalents (Median) |
|---|---|
| EXPAREL® Bupivacaine Liposome Suspension | 5 |
| Standard Periarticular Joint Injection | 5 |
17 trials available for bupivacaine and Osteoarthritis, Knee
| Article | Year |
|---|---|
Is there a difference in the analgesic response to intra-articular bupivacaine injection in people with knee osteoarthritis pain with or without central sensitisation? Protocol of a feasibility randomised controlled trial.
Topics: Analgesics; Bupivacaine; Central Nervous System Sensitization; Feasibility Studies; Humans; Injectio | 2023 |
Comparison of the Post-Total Knee Arthroplasty Analgesic Effect of Intraoperative Periarticular Injection of Different Analgesics.
Topics: Aged; Analgesia, Patient-Controlled; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Arthroplas | 2019 |
Study of Peri-Articular Anaesthetic for Replacement of the Knee (SPAARK): study protocol for a patient-blinded, randomised controlled superiority trial of liposomal bupivacaine.
Topics: Anesthetics, Local; Arthroplasty, Replacement, Knee; Bupivacaine; Cost-Benefit Analysis; Drug Costs; | 2019 |
Comparison of efficacy between combined periarticular and incisional injections versus periarticular injection alone of bupivacaine for pain control after total knee arthroplasty: A prospective randomized controlled trial.
Topics: Aged; Anesthetics, Local; Arthroplasty, Replacement, Knee; Bupivacaine; Double-Blind Method; Female; | 2020 |
Periarticular multimodal drug injection is better than single anesthetic drug in controlling pain after total knee arthroplasty.
Topics: Aged; Aged, 80 and over; Analgesics, Opioid; Anesthetics, Combined; Arthroplasty, Replacement, Knee; | 2018 |
Timing of periarticular injection has no effect on postoperative pain and functional recovery in simultaneous bilateral total knee arthroplasty: a prospective randomized, double-blinded trial.
Topics: Aged; Arthroplasty, Replacement, Knee; Bupivacaine; Double-Blind Method; Drug Administration Schedul | 2019 |
Ropivacaine versus bupivacaine for 3-in-1 block during total knee arthroplasty.
Topics: Aged; Amides; Anesthetics, Local; Arthroplasty, Replacement, Knee; Bupivacaine; Female; Femoral Nerv | 2013 |
Efficacy of periarticular multimodal drug injection after medial opening-wedge high tibial osteotomy: a randomized, controlled study.
Topics: Adult; Aged; Aged, 80 and over; Analgesics; Bupivacaine; Drug Combinations; Epinephrine; Female; Hum | 2014 |
Which one is more effective for the clinical treatment of chronic pain in knee osteoarthritis: radiofrequency neurotomy of the genicular nerves or intra-articular injection?
Topics: Aged; Aged, 80 and over; Analgesics; Analgesics, Opioid; Anesthetics, Local; Arthralgia; Betamethaso | 2018 |
Intra-articular morphine versus bupivacaine for knee motion among patients with osteoarthritis: randomized double-blind clinical trial.
Topics: Aged; Analgesics, Opioid; Analysis of Variance; Anesthetics, Local; Bupivacaine; Double-Blind Method | 2008 |
Efficacy of intra-articular cocktail analgesic injection in total knee arthroplasty - a randomized controlled trial.
Topics: Aged; Analgesia, Patient-Controlled; Analgesics; Arthroplasty, Replacement, Knee; Betamethasone; Bup | 2009 |
Efficacy of intra-articular cocktail analgesic injection in total knee arthroplasty - a randomized controlled trial.
Topics: Aged; Analgesia, Patient-Controlled; Analgesics; Arthroplasty, Replacement, Knee; Betamethasone; Bup | 2009 |
Efficacy of intra-articular cocktail analgesic injection in total knee arthroplasty - a randomized controlled trial.
Topics: Aged; Analgesia, Patient-Controlled; Analgesics; Arthroplasty, Replacement, Knee; Betamethasone; Bup | 2009 |
Efficacy of intra-articular cocktail analgesic injection in total knee arthroplasty - a randomized controlled trial.
Topics: Aged; Analgesia, Patient-Controlled; Analgesics; Arthroplasty, Replacement, Knee; Betamethasone; Bup | 2009 |
Efficacy of periarticular injection of bupivacaine, fentanyl, and methylprednisolone in total knee arthroplasty:a prospective, randomized trial.
Topics: Aged; Aged, 80 and over; Analgesics, Opioid; Anesthetics, Combined; Anesthetics, Local; Arthroplasty | 2010 |
Efficacy of periarticular injection of bupivacaine, fentanyl, and methylprednisolone in total knee arthroplasty:a prospective, randomized trial.
Topics: Aged; Aged, 80 and over; Analgesics, Opioid; Anesthetics, Combined; Anesthetics, Local; Arthroplasty | 2010 |
Efficacy of periarticular injection of bupivacaine, fentanyl, and methylprednisolone in total knee arthroplasty:a prospective, randomized trial.
Topics: Aged; Aged, 80 and over; Analgesics, Opioid; Anesthetics, Combined; Anesthetics, Local; Arthroplasty | 2010 |
Efficacy of periarticular injection of bupivacaine, fentanyl, and methylprednisolone in total knee arthroplasty:a prospective, randomized trial.
Topics: Aged; Aged, 80 and over; Analgesics, Opioid; Anesthetics, Combined; Anesthetics, Local; Arthroplasty | 2010 |
Intra-articular local anaesthetic on the day after surgery improves pain and patient satisfaction after Unicompartmental Knee Replacement: a randomised controlled trial.
Topics: Anesthetics, Local; Arthroplasty, Replacement, Knee; Bupivacaine; Double-Blind Method; Humans; Injec | 2012 |
Is intra-articular multimodal drug injection effective in pain management after total knee arthroplasty? A randomized, double-blinded, prospective study.
Topics: Aged; Aged, 80 and over; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthetics, Local; Anti | 2011 |
Three-in-one nerve block with different concentrations of bupivacaine in total knee arthroplasty: randomized, placebo-controlled, double-blind trial.
Topics: Aged; Aged, 80 and over; Arthralgia; Arthroplasty, Replacement, Knee; Bupivacaine; Dose-Response Rel | 2012 |
Preemptive oral rofecoxib plus postoperative intraarticular bupivacaine for pain relief after arthroscopic knee surgery.
Topics: Administration, Oral; Adult; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Arthroscop | 2005 |
Effect of pain reduction on postural sway, proprioception, and quadriceps strength in subjects with knee osteoarthritis.
Topics: Adult; Aged; Aged, 80 and over; Analgesics; Bupivacaine; Cross-Over Studies; Double-Blind Method; El | 2002 |
8 other studies available for bupivacaine and Osteoarthritis, Knee
| Article | Year |
|---|---|
Acetaminophen, bupivacaine, Duramorph, and Toradol: A comparison of chondrocyte viability and gene expression changes in osteoarthritic human chondrocytes.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthetics, Local; Apoptosis; Bupivaca | 2020 |
The Global Reading Room: Intraarticular Steroid Injection of the Knee.
Topics: Anesthetics, Local; Betamethasone; Bupivacaine; Female; Fluoroscopy; Glucocorticoids; Humans; Inject | 2021 |
Femoral Nerve Block Versus Long-Acting Wound Infiltration in Total Knee Arthroplasty.
Topics: Aged; Analgesia; Anesthetics, Local; Arthroplasty, Replacement, Knee; Bupivacaine; Female; Femoral N | 2016 |
Femoral Nerve Block Versus Long-Acting Wound Infiltration in Total Knee Arthroplasty.
Topics: Aged; Analgesia; Anesthetics, Local; Arthroplasty, Replacement, Knee; Bupivacaine; Female; Femoral N | 2016 |
Femoral Nerve Block Versus Long-Acting Wound Infiltration in Total Knee Arthroplasty.
Topics: Aged; Analgesia; Anesthetics, Local; Arthroplasty, Replacement, Knee; Bupivacaine; Female; Femoral N | 2016 |
Femoral Nerve Block Versus Long-Acting Wound Infiltration in Total Knee Arthroplasty.
Topics: Aged; Analgesia; Anesthetics, Local; Arthroplasty, Replacement, Knee; Bupivacaine; Female; Femoral N | 2016 |
Effects of Multiple Intra-articular Injections of 0.5% Bupivacaine on Normal and Osteoarthritic Joints in Rats.
Topics: Anesthetics, Local; Animals; Bupivacaine; Cartilage, Articular; Cell Count; Cell Survival; Chondrocy | 2016 |
Third-degree heart block associated with bupivacaine infusion following total knee arthroplasty. A case report.
Topics: Aged; Anesthetics, Local; Arthroplasty, Replacement, Knee; Bupivacaine; Female; Heart Block; Humans; | 2009 |
Complications of femoral nerve blockade in total knee arthroplasty and strategies to reduce patient risk.
Topics: Aged; Anesthetics, Local; Arthroplasty, Replacement, Knee; Bupivacaine; Catheters; Compartment Syndr | 2012 |
Cutaneous reactions to injectable corticosteroids.
Topics: Aged; Anti-Inflammatory Agents; Bupivacaine; Diagnosis, Differential; Drug Eruptions; Female; Humans | 2006 |
Pain control after knee arthroplasty: intraarticular versus epidural anesthesia.
Topics: Adult; Aged; Aged, 80 and over; Analgesia, Patient-Controlled; Anesthesia, Epidural; Anesthetics, Lo | 2001 |