Page last updated: 2024-10-24

bupivacaine and Obesity

bupivacaine has been researched along with Obesity in 17 studies

Bupivacaine: A widely used local anesthetic agent.
1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide : A piperidinecarboxamide obtained by formal condensation of the carboxy group of N-butylpipecolic acid with the amino group of 2,6-dimethylaniline.
bupivacaine : A racemate composed of equimolar amounts of dextrobupivacaine and levobupivacaine. Used (in the form of its hydrochloride hydrate) as a local anaesthetic.

Obesity: A status with BODY WEIGHT that is grossly above the recommended standards, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).

Research Excerpts

ExcerptRelevanceReference
"75% bupivacaine must frequently be augmented to provide adequate analgesia for cesarean section in thin parturients (BMI below 28) whereas it is too high a dosage for obese patients."5.26Obesity and the cephalad spread of analgesia following epidural administration of bupivacaine for Cesarean section. ( Hodgkinson, R; Husain, FJ, 1980)
"Obesity has been associated with chronic pain following TJA."1.48The Effects of Body Mass Index on Pain Control With Liposomal Bupivacaine in Hip and Knee Arthroplasty. ( Campbell, AL; Iorio, R; Karia, R; Stuchin, SA; Yu, S, 2018)
" Mean dosage of 0."1.46[Epidural analgesia in 20 parturients at the Sylvanus Olympio University Hospital Center in Lomé (Togo)]. ( Akala-Yoba, G; Assénouwé, S; Egbohou, P; Mouzou, T; Sama, HD; Tchétike, P; Tomta, K, 2017)
"Obesity has a significant effect on the cephalic spread of a spinal block (SB) due to a reduction in cerebrospinal fluid (CSF)."1.42The Levels and Duration of Sensory and Motor Blockades of Spinal Anesthesia in Obese Patients That Underwent Urological Operations in the Lithotomy Position. ( Ciftci, T; Daskaya, H; İnal, V; Kepekci, AB; Yavasca, HP, 2015)
" Further studies are necessary to confirm these findings in order to determine adequate local anaesthetic dosing for thoracic epidural analgesia in obese patients."1.39Postoperative epidural analgesia in obese patients undergoing liver resection surgery. ( Bellamy, M; Biercamp, C; Hudson-Phillips, S; Kocarev, M; Milan, Z; Pane, H; Procter, H; Rajasekar, N; Simpson, R, 2013)
"Local anesthetic inguinal hernia repair in the obese is safe and well tolerated."1.35Local anesthetic hernia repair in overweight and obese patients. ( Reid, TD; Sanjay, P; Woodward, A, 2009)
"1% w/v bupivacaine (20 mg), with a dosing increment of 0."1.33Obese parturients have lower epidural local anaesthetic requirements for analgesia in labour. ( Columb, MO; Panni, MK, 2006)
"75% bupivacaine must frequently be augmented to provide adequate analgesia for cesarean section in thin parturients (BMI below 28) whereas it is too high a dosage for obese patients."1.26Obesity and the cephalad spread of analgesia following epidural administration of bupivacaine for Cesarean section. ( Hodgkinson, R; Husain, FJ, 1980)

Research

Studies (17)

TimeframeStudies, this research(%)All Research%
pre-19903 (17.65)18.7374
1990's2 (11.76)18.2507
2000's4 (23.53)29.6817
2010's8 (47.06)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Egbohou, P1
Mouzou, T1
Sama, HD1
Tchétike, P1
Assénouwé, S1
Akala-Yoba, G1
Tomta, K1
Campbell, AL1
Yu, S1
Karia, R1
Iorio, R1
Stuchin, SA1
Araco, A2
Araco, F2
Gravante, G2
Ciftci, T1
Kepekci, AB1
Yavasca, HP1
Daskaya, H1
İnal, V1
Ngaka, TC1
Coetzee, JF1
Dyer, RA1
Reid, TD1
Sanjay, P1
Woodward, A1
Pooney, J1
Kim, WH1
Lee, JH1
Ko, JS1
Ahn, HJ1
Park, SK1
Gwak, MS1
Kim, GS1
Milan, Z1
Rajasekar, N1
Hudson-Phillips, S1
Pane, H1
Procter, H1
Simpson, R1
Kocarev, M1
Biercamp, C1
Bellamy, M1
Lim, Y1
Loo, CC1
Goh, E1
Panni, MK1
Columb, MO1
Varela, C1
Palacio, F1
Reina, MA1
López, A1
Benito-León, J1
Rucci, FS1
Migliori, P1
Lisi, A1
Cardamone, M1
Hodgkinson, R1
Husain, FJ1
Toyota, K1
Sakura, S1
Fukuda, N1
Saito, Y1
Taivainen, T1
Tuominen, M1
Rosenberg, PH1
McCulloch, WJ1
Littlewood, DG1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Effectiveness of Subarachnoid Hyperbaric Bupivacaine on Mean Arterial Blood Pressure in Pregnant Patients With Obesity Operated by Cesarean Section[NCT04205344]Phase 440 participants (Actual)Interventional2017-02-01Completed
Effect of Subarachnoid Hyperbaric Bupivacaine on Mean Arterial Pressure in Obese Pregnant Patients Undergoing Cesarean Section[NCT06060015]Phase 4106 participants (Anticipated)Interventional2023-08-01Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

2 trials available for bupivacaine and Obesity

ArticleYear
The effect of body mass index on spinal anaesthesia for total knee replacement arthroplasty: a dose-response study.
    Anaesthesia and intensive care, 2012, Volume: 40, Issue:3

    Topics: Aged; Anesthesia, Spinal; Anesthetics, Local; Arthroplasty, Replacement, Knee; Body Mass Index; Bupi

2012
Influence of obesity on the spread of spinal analgesia after injection of plain 0.5% bupivacaine at the L3-4 or L4-5 interspace.
    British journal of anaesthesia, 1990, Volume: 64, Issue:5

    Topics: Adult; Anesthesia, Spinal; Bupivacaine; Female; Humans; Male; Middle Aged; Motor Neurons; Neurons, A

1990

Other Studies

15 other studies available for bupivacaine and Obesity

ArticleYear
[Epidural analgesia in 20 parturients at the Sylvanus Olympio University Hospital Center in Lomé (Togo)].
    The Pan African medical journal, 2017, Volume: 26

    Topics: Adult; Analgesia, Epidural; Anesthesia, Epidural; Anesthesia, Obstetrical; Bupivacaine; Cesarean Sec

2017
The Effects of Body Mass Index on Pain Control With Liposomal Bupivacaine in Hip and Knee Arthroplasty.
    The Journal of arthroplasty, 2018, Volume: 33, Issue:4

    Topics: Adult; Aged; Anesthetics, Local; Arthroplasty, Replacement, Hip; Arthroplasty, Replacement, Knee; Bo

2018
The transversus abdominis plane block after postbariatric abdominoplasty: reasons for pitfalls.
    The American surgeon, 2013, Volume: 79, Issue:12

    Topics: Abdominal Muscles; Abdominoplasty; Adult; Analgesics; Anesthetics, Local; Bariatric Surgery; Bupivac

2013
The Levels and Duration of Sensory and Motor Blockades of Spinal Anesthesia in Obese Patients That Underwent Urological Operations in the Lithotomy Position.
    BioMed research international, 2015, Volume: 2015

    Topics: Aged; Anesthesia, Spinal; Bupivacaine; Hemodynamics; Humans; Male; Middle Aged; Obesity; Supine Posi

2015
The Influence of Body Mass Index on Sensorimotor Block and Vasopressor Requirement During Spinal Anesthesia for Elective Cesarean Delivery.
    Anesthesia and analgesia, 2016, Volume: 123, Issue:6

    Topics: Adult; Analgesics, Opioid; Anesthesia, Obstetrical; Anesthesia, Spinal; Anesthetics, Local; Body Mas

2016
The Influence of Body Mass Index on Sensorimotor Block and Vasopressor Requirement During Spinal Anesthesia for Elective Cesarean Delivery.
    Anesthesia and analgesia, 2016, Volume: 123, Issue:6

    Topics: Adult; Analgesics, Opioid; Anesthesia, Obstetrical; Anesthesia, Spinal; Anesthetics, Local; Body Mas

2016
The Influence of Body Mass Index on Sensorimotor Block and Vasopressor Requirement During Spinal Anesthesia for Elective Cesarean Delivery.
    Anesthesia and analgesia, 2016, Volume: 123, Issue:6

    Topics: Adult; Analgesics, Opioid; Anesthesia, Obstetrical; Anesthesia, Spinal; Anesthetics, Local; Body Mas

2016
The Influence of Body Mass Index on Sensorimotor Block and Vasopressor Requirement During Spinal Anesthesia for Elective Cesarean Delivery.
    Anesthesia and analgesia, 2016, Volume: 123, Issue:6

    Topics: Adult; Analgesics, Opioid; Anesthesia, Obstetrical; Anesthesia, Spinal; Anesthetics, Local; Body Mas

2016
Local anesthetic hernia repair in overweight and obese patients.
    World journal of surgery, 2009, Volume: 33, Issue:1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anesthesia, Local; Anesthetics, Local; Body Mass Index;

2009
Transversus abdominis plane block reduces the analgesic requirements after abdominoplasty with flank liposuction.
    Annals of plastic surgery, 2010, Volume: 65, Issue:4

    Topics: Abdominal Fat; Abdominal Muscles; Adult; Analysis of Variance; Body Mass Index; Bupivacaine; Case-Co

2010
Postoperative epidural analgesia in obese patients undergoing liver resection surgery.
    Medicinski glasnik : official publication of the Medical Association of Zenica-Doboj Canton, Bosnia and Herzegovina, 2013, Volume: 10, Issue:1

    Topics: Aged; Analgesia, Epidural; Anesthesia, General; Anesthetics; Body Mass Index; Bupivacaine; Drug Ther

2013
Ultra low dose combined spinal and epidural anesthesia for cesarean section.
    International journal of obstetric anesthesia, 2004, Volume: 13, Issue:3

    Topics: Adjuvants, Anesthesia; Adult; Anesthesia, Epidural; Anesthesia, Obstetrical; Anesthesia, Spinal; Ane

2004
Obese parturients have lower epidural local anaesthetic requirements for analgesia in labour.
    British journal of anaesthesia, 2006, Volume: 96, Issue:1

    Topics: Adult; Analgesia, Epidural; Analgesia, Obstetrical; Anesthetics, Local; Anthropometry; Body Mass Ind

2006
[Horner's syndrome secondary to epidural anesthesia].
    Neurologia (Barcelona, Spain), 2007, Volume: 22, Issue:3

    Topics: Adult; Anesthesia, Epidural; Anesthesia, Obstetrical; Anesthetics, Local; Arm; Bupivacaine; Cesarean

2007
[Clinico-statistical study on various factors that could influence the area of analgesia in lumbar epidural block].
    Minerva anestesiologica, 1984, Volume: 50, Issue:10

    Topics: Adolescent; Adult; Aged; Anesthesia, Epidural; Anesthetics; Body Height; Body Weight; Bupivacaine; F

1984
Obesity and the cephalad spread of analgesia following epidural administration of bupivacaine for Cesarean section.
    Anesthesia and analgesia, 1980, Volume: 59, Issue:2

    Topics: Adult; Age Factors; Analgesia; Anesthesia, Epidural; Anesthesia, Obstetrical; Body Height; Body Weig

1980
[Epidural anesthesia and general anesthesia using the cuffed oropharyngeal airway for an obese patient with Duchenne's muscular dystrophy].
    Masui. The Japanese journal of anesthesiology, 1999, Volume: 48, Issue:12

    Topics: Analgesia, Epidural; Anesthesia, Epidural; Anesthesia, General; Anesthetics, Local; Breast Neoplasms

1999
Influence of obesity on spinal analgesia with isobaric 0.5% bupivacaine.
    British journal of anaesthesia, 1986, Volume: 58, Issue:6

    Topics: Aged; Anesthesia, Spinal; Bupivacaine; Humans; Male; Middle Aged; Obesity; Specific Gravity

1986