bupivacaine has been researched along with Neuroblastoma in 6 studies
Bupivacaine: A widely used local anesthetic agent.
1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide : A piperidinecarboxamide obtained by formal condensation of the carboxy group of N-butylpipecolic acid with the amino group of 2,6-dimethylaniline.
bupivacaine : A racemate composed of equimolar amounts of dextrobupivacaine and levobupivacaine. Used (in the form of its hydrochloride hydrate) as a local anaesthetic.
Neuroblastoma: A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)
| Excerpt | Relevance | Reference |
|---|---|---|
| " In the current study, we explored the mechanisms by which microRNA-132 (miR-132) regulated the neurotoxicity of human neuroblastoma cells (SH-SY5Y) induced by bupivacaine (BUP)." | 7.91 | Effect of miR-132 on bupivacaine-induced neurotoxicity in human neuroblastoma cell line. ( He, Q; Hu, T; Lin, J; Ren, Z; Wang, W; Zhang, H, 2019) |
| "Cells of the neuroblastoma line N2a (Neuro2a cells) were divided into three experimental groups: control, bupivacaine-treated, and bupivacaine-treated with GM-1 pretreatment." | 7.83 | The Ganglioside GM-1 Inhibits Bupivacaine-Induced Neurotoxicity in Mouse Neuroblastoma Neuro2a Cells. ( He, Y; Ji, J; Liang, Y; Lin, Y; Liu, J, 2016) |
| " In the current study, we explored the mechanisms by which microRNA-132 (miR-132) regulated the neurotoxicity of human neuroblastoma cells (SH-SY5Y) induced by bupivacaine (BUP)." | 3.91 | Effect of miR-132 on bupivacaine-induced neurotoxicity in human neuroblastoma cell line. ( He, Q; Hu, T; Lin, J; Ren, Z; Wang, W; Zhang, H, 2019) |
| "Cells of the neuroblastoma line N2a (Neuro2a cells) were divided into three experimental groups: control, bupivacaine-treated, and bupivacaine-treated with GM-1 pretreatment." | 3.83 | The Ganglioside GM-1 Inhibits Bupivacaine-Induced Neurotoxicity in Mouse Neuroblastoma Neuro2a Cells. ( He, Y; Ji, J; Liang, Y; Lin, Y; Liu, J, 2016) |
| "To evaluate our hypothesis, we treated mouse neuroblastoma N2a cells with LA 30 min before the cells were exposed to bupivacaine." | 3.76 | Alpha-lipoic acid prevents bupivacaine-induced neuron injury in vitro through a PI3K/Akt-dependent mechanism. ( Cheng, Y; Ding, Z; Li, C; Liu, L; Wang, X; Zhang, W; Zhang, X, 2010) |
| "Lidocaine treatment resulted in suppression of the mitochondrial electron transport chain and subsequent attenuation of mitochondrial membrane potential, as well as enhanced ROS production, activation of caspase-3/7 and caspase-9, and induction of apoptosis and necrosis in SH-SY5Y cells in a dose- and time-dependent manner." | 1.43 | The antioxidant N-acetyl cysteine suppresses lidocaine-induced intracellular reactive oxygen species production and cell death in neuronal SH-SY5Y cells. ( Hirota, K; Kusunoki, M; Matsuo, Y; Nishi, K; Okamoto, A; Oku, K; Shingu, K; Sumi, C; Takenaga, K; Tanaka, M, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (66.67) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| de Freitas Domingues, JS | 1 |
| Dos Santos, SMD | 1 |
| das Neves Rodrigues Ferreira, J | 1 |
| Monti, BM | 1 |
| Baggio, DF | 1 |
| Hummig, W | 1 |
| Araya, EI | 1 |
| de Paula, E | 1 |
| Chichorro, JG | 1 |
| Ferreira, LEN | 1 |
| Zhang, H | 1 |
| Lin, J | 1 |
| Hu, T | 1 |
| Ren, Z | 1 |
| Wang, W | 1 |
| He, Q | 1 |
| Liang, Y | 1 |
| Ji, J | 1 |
| Lin, Y | 1 |
| He, Y | 1 |
| Liu, J | 1 |
| Okamoto, A | 1 |
| Tanaka, M | 1 |
| Sumi, C | 1 |
| Oku, K | 1 |
| Kusunoki, M | 1 |
| Nishi, K | 1 |
| Matsuo, Y | 1 |
| Takenaga, K | 1 |
| Shingu, K | 1 |
| Hirota, K | 1 |
| Wang, X | 1 |
| Zhang, X | 1 |
| Cheng, Y | 1 |
| Li, C | 1 |
| Zhang, W | 1 |
| Liu, L | 1 |
| Ding, Z | 1 |
| Hilton, AB | 1 |
| Lockhart, EM | 1 |
| Penning, DH | 1 |
6 other studies available for bupivacaine and Neuroblastoma
| Article | Year |
|---|---|
Antinociceptive effects of bupivacaine and its sulfobutylether-β-cyclodextrin inclusion complex in orofacial pain.
Topics: Analgesics; beta-Cyclodextrins; Biological Products; Bupivacaine; Carrageenan; Cyclodextrins; Facial | 2022 |
Effect of miR-132 on bupivacaine-induced neurotoxicity in human neuroblastoma cell line.
Topics: Anesthetics, Local; Apoptosis; Bupivacaine; Cell Line, Tumor; Cell Survival; Flow Cytometry; Humans; | 2019 |
The Ganglioside GM-1 Inhibits Bupivacaine-Induced Neurotoxicity in Mouse Neuroblastoma Neuro2a Cells.
Topics: Animals; Apoptosis; Bisbenzimidazole; Blotting, Western; Bupivacaine; Cell Line, Tumor; Cell Surviva | 2016 |
The antioxidant N-acetyl cysteine suppresses lidocaine-induced intracellular reactive oxygen species production and cell death in neuronal SH-SY5Y cells.
Topics: Acetylcysteine; Anesthetics, Local; Antioxidants; Apoptosis; Bupivacaine; Cell Death; Cell Line, Tum | 2016 |
Alpha-lipoic acid prevents bupivacaine-induced neuron injury in vitro through a PI3K/Akt-dependent mechanism.
Topics: Anesthetics, Local; Animals; Animals, Newborn; Annexin A5; Apoptosis; Bupivacaine; Cell Line, Tumor; | 2010 |
Epidural analgesia in parturients with previous spinal irradiation.
Topics: Adolescent; Adult; Analgesia, Epidural; Analgesia, Obstetrical; Analgesics, Opioid; Anesthetics, Loc | 1998 |