Page last updated: 2024-10-24

bupivacaine and Neuralgia

bupivacaine has been researched along with Neuralgia in 65 studies

Bupivacaine: A widely used local anesthetic agent.
1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide : A piperidinecarboxamide obtained by formal condensation of the carboxy group of N-butylpipecolic acid with the amino group of 2,6-dimethylaniline.
bupivacaine : A racemate composed of equimolar amounts of dextrobupivacaine and levobupivacaine. Used (in the form of its hydrochloride hydrate) as a local anaesthetic.

Neuralgia: Intense or aching pain that occurs along the course or distribution of a peripheral or cranial nerve.

Research Excerpts

ExcerptRelevanceReference
"Four patients with postherpetic neuralgia had their pain alleviated by epidural administration of ketamine."7.71[Usefulness of epidural administration of ketamine for relief of postherpetic neuralgia]. ( Ikeda, M; Machida, K; Mikawa, Y; Mizuno, J; Sugimoto, S, 2001)
" In the present case report, two patients with reflex sympathetic dystrophy were treated with ketamine, a NMDA antagonist, morphine and bupivacaine."7.70Long-term epidural ketamine, morphine and bupivacaine attenuate reflex sympathetic dystrophy neuralgia. ( Chen, FC; Ho, ST; Lin, SY; Lin, TC; Wong, CS, 1998)
"5% bupivacaine to a patient with post-herpetic neuralgia in the thoracic region."7.67Horner's syndrome after intrapleural anesthesia with bupivacaine for post-herpetic neuralgia. ( Holmblad, BR; Sihota, MK, 1988)
" The result strongly suggests a synergy from this combination that warrants a formal study of the dose-response relationship involved in this treatment and the mechanism by which this effect is achieved."5.29Epidural coadministration of ketamine, morphine and bupivacaine attenuates post-herpetic neuralgia--a case report. ( Cherng, CH; Ho, ST; Liaw, WJ; Shen, TT; Wong, CS, 1996)
" In the second part, eight patients with herpetic neuralgia received epidural analgesia at the fourth to eighth thoracic interspace, using bupivacaine 0."5.06Cerebrospinal norepinephrine concentrations and the duration of epidural analgesia. ( Fujita, N; Fujita, T; Goto, F, 1990)
"In our previous study, we concluded that an epidural blockade combined with intravenous acyclovir is very effective in treating the acute pain in herpes zoster and postherpetic neuralgia."3.71The effects of famciclovir and epidural block in the treatment of herpes zoster. ( Ahn, HJ; Ahn, SK; Choi, EH; Hwang, SM; Lee, WS; Lee, YB; Lim, HK, 2001)
"Four patients with postherpetic neuralgia had their pain alleviated by epidural administration of ketamine."3.71[Usefulness of epidural administration of ketamine for relief of postherpetic neuralgia]. ( Ikeda, M; Machida, K; Mikawa, Y; Mizuno, J; Sugimoto, S, 2001)
" In the present case report, two patients with reflex sympathetic dystrophy were treated with ketamine, a NMDA antagonist, morphine and bupivacaine."3.70Long-term epidural ketamine, morphine and bupivacaine attenuate reflex sympathetic dystrophy neuralgia. ( Chen, FC; Ho, ST; Lin, SY; Lin, TC; Wong, CS, 1998)
"5% bupivacaine to a patient with post-herpetic neuralgia in the thoracic region."3.67Horner's syndrome after intrapleural anesthesia with bupivacaine for post-herpetic neuralgia. ( Holmblad, BR; Sihota, MK, 1988)
"We treated 12 cases of cutaneous herpes zoster (HZ) with epidural bupivacaine and methylprednisolone acetate."3.66Epidural injection of local anesthetic and steroids for relief of pain secondary to herpes zoster. ( Hanlon, PR; Perkins, HM, 1978)
"Peripheral neuropathic pain (PNP) associated with trauma is often refractory to treatment."2.82Study protocol for a pilot, randomised, double-blinded, placebo controlled trial of perineural local anaesthetics and steroids for chronic post-traumatic neuropathic pain in the ankle and foot: the PREPLANS study. ( Alvi, S; Bhatia, A; Bril, V; Brull, RT; Davis, AM; Gandhi, R; Lau, J; Mahomed, N; Perruccio, A; Wijeysundera, D, 2016)
"The frequency of neuropathic pain was assessed using the Douleur Neuropathique 4-question survey (DN4) in the first and second postoperative months."2.78Effect of the addition of clonidine to locally administered bupivacaine on acute and chronic postmastectomy pain. ( Abdel-Ghaffar, HS; Mohamed, SA, 2013)
"Chronic neuropathic pain following traumatic brachial plexus injury could be successfully managed by chemical neurolysis and oral gabapentin."1.51Management of neuropathic pain following traumatic brachial plexus injury with neurolysis and oral gabapentin: A case report. ( Aaron, OI; Adetoye, AO; Orimolade, EA; P Adetifa, KA, 2019)
"Lacrimal neuralgia has been recently described as a pain in the territory supplied by the lacrimal nerve, at the lateral upper eyelid and/or the adjacent area of the temple."1.46Lacrimal Nerve Blocks for Three New Cases of Lacrimal Neuralgia. ( Cuadrado, ML; García-Moreno, H; Gutiérrez-Viedma, Á; Orviz, A; Silva-Hernández, L, 2017)
"Persistent pain after breast cancer surgery (PPBCS) affects 25 - 60% of breast cancer survivors and damage to the intercostobrachial nerve (ICBN) has been implicated as the cause of this predominantly neuropathic pain."1.43Ultrasound Guided Intercostobrachial Nerve Blockade in Patients with Persistent Pain after Breast Cancer Surgery: A Pilot Study. ( Andersen, KG; Anderson, KG; Duriaud, HM; Kehlet, H; Wijayasinghe, N, 2016)
"Patients with neuropathic pain commonly present with spontaneous pain, in addition to allodynia and hyperalgesia."1.42Conditioned place preference and spontaneous dorsal horn neuron activity in chronic constriction injury model in rats. ( Brennan, TJ; Dalm, BD; Howard, MA; Kang, S; Reddy, CG, 2015)
"Antiepileptics used for treating neuropathic pain have various actions including voltage-gated Na(+) and Ca(2+) channels, glutamate-receptor inhibition, and GABA(A)-receptor activation, while local anesthetics are also used to alleviate the pain."1.40Effects of various antiepileptics used to alleviate neuropathic pain on compound action potential in frog sciatic nerves: comparison with those of local anesthetics. ( Fujita, T; Hirakawa, N; Kumamoto, E; Ohtsubo, S; Sakaguchi, Y; Uemura, Y, 2014)
"Levobupivacaine was more potent than lidocaine in all tests employed on diabetic rats."1.39Comparison of actions of systemically and locally administrated local anaesthetics in diabetic rats with painful neuropathy. ( Gunay, I; Gunes, Y; Mert, T, 2013)
"The pathophysiology of many types of chronic headaches is not well understood."1.33Cervicogenic headache in patients with presumed migraine: missed diagnosis or misdiagnosis? ( Cook, AJ; Hamill-Ruth, RJ; Rowlingson, JC; Yi, X, 2005)
"Intercostal neuralgia is one of many possible neurological disorders associated with pregnancy."1.29Long-term epidural analgesia for pregnancy-induced intercostal neuralgia. ( Dews, TE; Samlaska, S, 1995)
" The result strongly suggests a synergy from this combination that warrants a formal study of the dose-response relationship involved in this treatment and the mechanism by which this effect is achieved."1.29Epidural coadministration of ketamine, morphine and bupivacaine attenuates post-herpetic neuralgia--a case report. ( Cherng, CH; Ho, ST; Liaw, WJ; Shen, TT; Wong, CS, 1996)

Research

Studies (65)

TimeframeStudies, this research(%)All Research%
pre-199010 (15.38)18.7374
1990's14 (21.54)18.2507
2000's17 (26.15)29.6817
2010's22 (33.85)24.3611
2020's2 (3.08)2.80

Authors

AuthorsStudies
Wu, CC1
Chang, CY1
Tzeng, CY1
Huang, JH1
Hung, CJ1
Chen, WY1
Liao, SL1
Kuan, YH1
Chen, CJ1
Yalamanchili, SP1
Hertle, RW1
Adetoye, AO1
Aaron, OI1
Orimolade, EA1
P Adetifa, KA1
Benkli, B1
Ansoanuur, G1
Hernandez, N1
Ahiskalioglu, A1
Alici, HA1
Ari, MA1
Ju, Y1
Tian, D1
Tan, Y1
Fu, Z1
Balaban, O1
Aydin, T1
Yaman, M1
Thompson, EN1
Usichenko, T1
Cuadrado, ML4
Aledo-Serrano, A2
Jorquera, M1
Porta-Etessam, J1
Pareja, JA1
Uemura, Y1
Fujita, T2
Ohtsubo, S1
Hirakawa, N1
Sakaguchi, Y1
Kumamoto, E1
Iwanowski, P1
Kozubski, W1
Losy, J1
García-Moreno, H3
Gimeno-Hernández, J1
Cohen, SP1
Peterlin, BL1
Fulton, L1
Neely, ET1
Kurihara, C1
Gupta, A1
Mali, J1
Fu, DC1
Jacobs, MB1
Plunkett, AR1
Verdun, AJ1
Stojanovic, MP1
Hanling, S1
Constantinescu, O1
White, RL1
McLean, BC1
Pasquina, PF1
Zhao, Z1
Dalm, BD1
Reddy, CG1
Howard, MA1
Kang, S1
Brennan, TJ1
Hayek, SM1
Sweet, JA1
Miller, JP1
Sayegh, RR1
Wijayasinghe, N1
Duriaud, HM1
Kehlet, H1
Andersen, KG1
Anderson, KG1
Bhatia, A1
Bril, V1
Brull, RT1
Perruccio, A1
Wijeysundera, D1
Alvi, S1
Lau, J1
Gandhi, R1
Mahomed, N1
Davis, AM1
Gutiérrez-Viedma, Á1
Silva-Hernández, L1
Orviz, A1
Xie, W1
Strong, JA1
Zhang, JM1
Hahn, L1
Mert, T1
Gunes, Y1
Gunay, I1
Guirguis, MN1
Abd-Elsayed, AA1
Girgis, G1
Soliman, LM1
Klessinger, S1
Mohamed, SA1
Abdel-Ghaffar, HS1
Hough, DM1
Wittenberg, KH1
Pawlina, W1
Maus, TP1
King, BF1
Vrtiska, TJ1
Farrell, MA1
Antolak, SJ1
Gruber, H1
Bodner, G1
Mason, JO1
Katz, B1
Greene, HH1
McAllister, RK1
Carpentier, BW1
Malkuch, G1
Hardy, D1
Yi, X1
Cook, AJ1
Hamill-Ruth, RJ1
Rowlingson, JC1
Naja, MZ1
Al-Tannir, MA1
Maaliki, H1
El-Rajab, M1
Ziade, MF1
Zeidan, A1
Wen, YR1
Suter, MR1
Kawasaki, Y1
Huang, J1
Pertin, M1
Kohno, T1
Berde, CB1
Decosterd, I1
Ji, RR1
Ju, H1
Feng, Y1
Yang, BX1
Wang, J1
Laban, MM1
Grant, AJ1
Wood, C1
Miller, I1
Schreuder, M1
Khoury, R1
Kennedy, SF1
Macnamara, TE1
Rifat, SF1
Lombardo, JA1
Cheema, SP1
Ilsley, D1
Richardson, J1
Sabanathan, S1
Samlaska, S1
Dews, TE1
Vanamo, R1
Vähämurto, M1
Siitonen, O1
Wong, CS2
Shen, TT1
Liaw, WJ1
Cherng, CH1
Ho, ST2
Lin, TC1
Chen, FC1
Lin, SY1
Elias, M1
Boezaart, AP1
du Toit, JC1
van Lill, G1
Donald, R1
van der Spuy, G1
Bolus, M1
Hwang, SM2
Kang, YC1
Lee, YB2
Yoon, KB1
Ahn, SK2
Choi, EH2
Bourlon-Figuet, S1
Dubousset, AM1
Benhamou, D1
Mazoit, JX1
Ahn, HJ1
Lim, HK1
Lee, WS1
Yokoyama, M1
Ohashi, I1
Nakatsuka, H1
Mizobuchi, S1
Toda, Y1
Matsumi, M1
Morita, K1
Hirakawa, M1
Mizuno, J1
Sugimoto, S1
Ikeda, M2
Machida, K1
Mikawa, Y1
Bleeker, CP1
Bremer, RC1
Dongelmans, DA1
van Dongen, RT1
Crul, BJ1
Perkins, HM1
Hanlon, PR1
Parris, WC1
Currey, TA1
Dalsania, J1
Klein, DS1
Schmidt, RE1
Goto, F1
Fujita, N1
de Vries, N1
Smelt, WL1
Defalque, RJ1
Bromley, JJ1
Sihota, MK1
Holmblad, BR1
Ackerman, WE1
Zinke, R1
Hannington-Kiff, JG1
Swerdlow, M1

Clinical Trials (13)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Comparison of Heated vs. Pulsed Radiofrequency Treatment of the Genicular Nerves for Osteoarthritis Knee Pain[NCT04379895]60 participants (Anticipated)Interventional2020-06-30Not yet recruiting
A Comparison of Pain Control AND Quality of Life Improvement Between Occipital Nerve Block And Occipital Nerve Radiofrequency Ablation: A Double-Blind Single Center Prospective Study[NCT04124458]70 participants (Anticipated)Interventional2023-01-02Not yet recruiting
Pulsed vs Continuous Radiofrequency Neurotomy for Cervical Facet Joint Mediated Pain: a Single-blind Randomized Controlled Clinical Trial[NCT04124445]88 participants (Anticipated)Interventional2020-02-10Recruiting
Randomized, Double-blind, Comparative-effectiveness Study Comparing Corticosteroid Injections to Pulsed Radiofrequency for Occipital Neuralgia[NCT01670825]81 participants (Actual)Interventional2012-08-31Completed
Greater Occipital Nerve Pulsed Radiofrequency for the Treatment of Combined Migraine and Cervicogenic Headache (New Approach): Randomized Clinical Trial[NCT06121037]60 participants (Actual)Interventional2022-01-01Completed
A Pilot Randomized Controlled Trial of Efficacy of Perineural Local Anesthetics and Steroids for Chronic Post-traumatic Neuropathic Pain in the Ankle and the Foot: The PREPLAN Study[NCT02680548]Early Phase 18 participants (Actual)Interventional2015-11-30Completed
Pain Control After VATS Anatomical Pulmonary Resections: Randomized Comparison Between Cryoanalgesia, Erector Spinae Plane Block and Epidural Catheter[NCT05993273]75 participants (Anticipated)Interventional2023-04-05Recruiting
Cryoanalgesia and Post-thoracotomy Pain in Minimally Invasive Cardiothoracic Surgery[NCT05255146]100 participants (Anticipated)Interventional2023-12-31Not yet recruiting
The Effect of Cryoneurolysis for the Treatment of Acute Postoperative Pain Following Total Knee Arthroplasty in High Pain Responders - A Randomized, Participant- and Observer-masked, Sham-controlled Trial[NCT06088602]44 participants (Anticipated)Interventional2023-11-30Not yet recruiting
Evaluation of the Efficacy of Adding Magnesium Sulfate as an Adjuvant to Bupivacaine in Bilateral Ultrasound Guided Paravertebral Block for Laparoscopic Cholecystectomy[NCT05099250]50 participants (Actual)Interventional2019-07-15Completed
Analgesic and Hemodynamic Effects of Continuous Epidural Analgesia Compared to Paravertebral Block in Liver Resection Patients[NCT02909322]Phase 450 participants (Anticipated)Interventional2016-04-30Recruiting
A Comparison of Ultrasound-assisted Paravertebral Block and General Anesthesia for Outpatient Breast Cancer Surgery, a Prospective Randomized Trial[NCT00645138]Phase 340 participants (Anticipated)Interventional2008-04-30Completed
Comparison of the Effects of Perioperative Anesthesia Consumption of Ultrasound Guided Subcostal Transversus Abdominis Plane and Paravertebral Block in Laparoscopic Cholecystectomy[NCT02379780]50 participants (Actual)Interventional2014-09-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Change in Average Occipital Pain 2 Weeks After the Start of Treatment

This outcome measures the change in the numeric pain scale score from baseline to 2 weeks after treatment. The scale ranges from 0-10. The minimum score is 0 which is defined as no pain and the maximum score is 10, which is defined as the worst pain imaginable. The best possible outcome would be a 0. The worst possible outcome would be a 10. (NCT01670825)
Timeframe: From baseline to 2 weeks after the start of treatment

Interventionunits on a scale (Mean)
Pulsed Radiofrequency + Local Anesthetic Injection2.495
Corticosteroid Injection + Sham Pulsed Radiofrequency3.694

Change in Average Occipital Pain 3 Months After the Start of Treatment

This outcome measures the change in the numeric pain scale score from baseline to 3 months after treatment. The scale ranges from 0-10. The minimum score is 0 which is defined as no pain and the maximum score is 10, which is defined as the worst pain imaginable. The best possible outcome would be a 0. The worst possible outcome would be a 10. (NCT01670825)
Timeframe: From baseline to 3 months after the start of treatment

Interventionunits on a scale (Mean)
Pulsed Radiofrequency + Local Anesthetic Injection3.791
Corticosteroid Injection + Sham Pulsed Radiofrequency4.441

Change in Average Occipital Pain 6 Months After the Start of Treatment

The change in the numeric pain scale score from baseline to 6 months after treatment. The scale ranges from 0-10. The minimum score is 0 which is defined as no pain and the maximum score is 10, which is defined as the worst pain imaginable. The best possible outcome would be a 0. The worst possible outcome would be a 10. (NCT01670825)
Timeframe: From baseline to 6 months after the start of treatment

Interventionunits on a scale (Mean)
Pulsed Radiofrequency + Local Anesthetic Injection4.312
Corticosteroid Injection + Sham Pulsed Radiofrequency4.765

Change in Average Occipital Pain 6 Weeks After the Start of Treatment

The change in the numeric pain scale score from baseline to 6 weeks after treatment. The scale ranges from 0-10. The minimum score is 0 which is defined as no pain and the maximum score is 10, which is defined as the worst pain imaginable. The best possible outcome would be a 0. The worst possible outcome would be a 10. (NCT01670825)
Timeframe: From baseline to 6 weeks after the start of treatment

Interventionunits on a scale (Mean)
Pulsed Radiofrequency + Local Anesthetic Injection3.068
Corticosteroid Injection + Sham Pulsed Radiofrequency3.738

Change in Overall Average Headache Pain 2 Weeks After the Start of Treatment

This outcome measures the change in the numeric pain scale score from baseline to 2 weeks after treatment. The scale ranges from 0-10. The minimum score is 0 which is defined as no pain and the maximum score is 10, which is defined as the worst pain imaginable. The best possible outcome would be a 0. The worst possible outcome would be a 10. (NCT01670825)
Timeframe: From baseline to 2 weeks after the start of treatment

Interventionunits on a scale (Mean)
Pulsed Radiofrequency + Local Anesthetic Injection3.392
Corticosteroid Injection + Sham Pulsed Radiofrequency4.220

Change in Overall Average Headache Pain 3 Months After the Start of Treatment

This outcome measures the change in the numeric pain scale score from baseline to 3 months after treatment. The scale ranges from 0-10. The minimum score is 0 which is defined as no pain and the maximum score is 10, which is defined as the worst pain imaginable. The best possible outcome would be a 0. The worst possible outcome would be a 10. (NCT01670825)
Timeframe: From baseline to 3 months after the start of treatment

Interventionunits on a scale (Mean)
Pulsed Radiofrequency + Local Anesthetic Injection4.000
Corticosteroid Injection + Sham Pulsed Radiofrequency4.694

Change in Overall Average Headache Pain 6 Months After the Start of Treatment

This outcome measures the change in the numeric pain scale score from baseline to 6 months after treatment. The scale ranges from 0-10. The minimum score is 0 which is defined as no pain and the maximum score is 10, which is defined as the worst pain imaginable. The best possible outcome would be a 0. The worst possible outcome would be a 10. (NCT01670825)
Timeframe: From baseline to 6 months after the start of treatment

Interventionunits on a scale (Mean)
Pulsed Radiofrequency + Local Anesthetic Injection6.761
Corticosteroid Injection + Sham Pulsed Radiofrequency7.556

Change in Overall Average Headache Pain 6 Weeks After the Start of Treatment

This outcome measures the change in the numeric pain scale score from baseline to 6 weeks after treatment. The scale ranges from 0-10. The minimum score is 0 which is defined as no pain and the maximum score is 10, which is defined as the worst pain imaginable. The best possible outcome would be a 0. The worst possible outcome would be a 10. (NCT01670825)
Timeframe: From baseline to 6 weeks after the start of treatment

Interventionunits on a scale (Mean)
Pulsed Radiofrequency + Local Anesthetic Injection3.678
Corticosteroid Injection + Sham Pulsed Radiofrequency4.410

Change in Overall Worst Headache Pain 2 Weeks After the Start of Treatment

This outcome measures the change in the numeric pain scale score from baseline to 2 weeks after treatment. The scale ranges from 0-10. The minimum score is 0 which is defined as no pain and the maximum score is 10, which is defined as the worst pain imaginable. The best possible outcome would be a 0. The worst possible outcome would be a 10. (NCT01670825)
Timeframe: From baseline to 2 weeks after the start of treatment

Interventionunits on a scale (Mean)
Pulsed Radiofrequency + Local Anesthetic Injection5.540
Corticosteroid Injection + Sham Pulsed Radiofrequency6.650

Change in Overall Worst Headache Pain 3 Months After the Start of Treatment

This outcome measures the change in the numeric pain scale score from baseline to 3 months after treatment. The scale ranges from 0-10. The minimum score is 0 which is defined as no pain and the maximum score is 10, which is defined as the worst pain imaginable. The best possible outcome would be a 0. The worst possible outcome would be a 10. (NCT01670825)
Timeframe: From baseline to 3 months after the start of treatment

Interventionunits on a scale (Mean)
Pulsed Radiofrequency + Local Anesthetic Injection6.522
Corticosteroid Injection + Sham Pulsed Radiofrequency7.417

Change in Overall Worst Headache Pain 6 Months After the Start of Treatment

This outcome measures the change in the numeric pain scale score from baseline to 6 months after treatment. The scale ranges from 0-10. The minimum score is 0 which is defined as no pain and the maximum score is 10, which is defined as the worst pain imaginable. The best possible outcome would be a 0. The worst possible outcome would be a 10. (NCT01670825)
Timeframe: From baseline to 6 months after the start of treatment

Interventionunits on a scale (Mean)
Pulsed Radiofrequency + Local Anesthetic Injection6.761
Corticosteroid Injection + Sham Pulsed Radiofrequency7.556

Change in Overall Worst Overall Headache Pain 6 Weeks After the Start of Treatment

This outcome measures the change in the numeric pain scale score from baseline to 6 weeks after treatment. The scale ranges from 0-10. The minimum score is 0 which is defined as no pain and the maximum score is 10, which is defined as the worst pain imaginable. The best possible outcome would be a 0. The worst possible outcome would be a 10. (NCT01670825)
Timeframe: From baseline to 6 weeks after the start of treatment

Interventionunits on a scale (Mean)
Pulsed Radiofrequency + Local Anesthetic Injection6.583
Corticosteroid Injection + Sham Pulsed Radiofrequency6.825

Change in the Presence of Insomnia 3 Months After the Start of Treatment Measured Using the Athens Insomnia Scale.

This outcome will measure the participant's perceived improvement in sleep using the Athens Insomnia Scale. Scores in this scale can range from 0 to 24. 0 being the best possible outcome and 24 being the worst possible outcome. A score greater than or equal to 6 indicates a presence of insomnia. (NCT01670825)
Timeframe: From baseline to 3 months after the start of treatment

Interventionunits on a scale (Mean)
Pulsed Radiofrequency + Local Anesthetic Injection9.539
Corticosteroid Injection + Sham Pulsed Radiofrequency9.069

Change in the Presence of Insomnia 6 Months After the Start of Treatment Measured Using the Athens Insomnia Scale.

This outcome will measure the participant's perceived improvement in sleep using the Athens Insomnia Scale. Scores in this scale can range from 0 to 24. 0 being the best possible outcome and 24 being the worst possible outcome. A score greater than or equal to 6 indicates a presence of insomnia. (NCT01670825)
Timeframe: From baseline to 6 months after the start of treatment

Interventionunits on a scale (Mean)
Pulsed Radiofrequency + Local Anesthetic Injection9.256
Corticosteroid Injection + Sham Pulsed Radiofrequency9.431

Change in the Presence of Insomnia 6 Weeks After the Start of Treatment Measured Using the Athens Insomnia Scale.

This outcome will measure the participant's perceived improvement in sleep using the Athens Insomnia Scale. Scores in this scale can range from 0 to 24. 0 being the best possible outcome and 24 being the worst possible outcome. A score greater than or equal to 6 indicates a presence of insomnia. (NCT01670825)
Timeframe: From baseline to 6 weeks after the start of treatment

Interventionunits on a scale (Mean)
Pulsed Radiofrequency + Local Anesthetic Injection10.025
Corticosteroid Injection + Sham Pulsed Radiofrequency8.132

Change in the Severity of Depression 3 Months After the Start of Treatment Measured Using the Beck's Depression Inventory

This outcome will measure the change in severity of depression using the Beck's Depression Inventory. Scores in this inventory can range from 0 to 63. 0 being the best possible outcome and 63 being the worst possible outcome. A score between 14 and 19 indicates mild depression and a score greater than or equal 29 indicates severe depression. (NCT01670825)
Timeframe: From baseline to 3 months after the start of treatment

Interventionunits on a scale (Mean)
Pulsed Radiofrequency + Local Anesthetic Injection11.333
Corticosteroid Injection + Sham Pulsed Radiofrequency11.972

Change in the Severity of Depression 6 Months After the Start of Treatment Measured Using the Beck's Depression Inventory

This outcome will measure the change in severity of depression using the Beck's Depression Inventory. Scores in this inventory can range from 0 to 63. 0 being the best possible outcome and 63 being the worst possible outcome. A score between 14 and 19 indicates mild depression and a score greater than or equal 29 indicates severe depression. (NCT01670825)
Timeframe: From baseline to 6 months after the start of treatment

Interventionunits on a scale (Mean)
Pulsed Radiofrequency + Local Anesthetic Injection12.590
Corticosteroid Injection + Sham Pulsed Radiofrequency12.250

Change in the Severity of Depression 6 Weeks After the Start of Treatment Measured Using the Beck's Depression Inventory

This outcome will measure the change in severity of depression using the Beck's Depression Inventory. Scores in this inventory can range from 0 to 63. 0 being the best possible outcome and 63 being the worst possible outcome. A score between 14 and 19 indicates mild depression and a score greater than or equal 29 indicates severe depression. (NCT01670825)
Timeframe: From baseline to 6 weeks after the start of treatment

Interventionunits on a scale (Mean)
Pulsed Radiofrequency + Local Anesthetic Injection12.775
Corticosteroid Injection + Sham Pulsed Radiofrequency10.842

Change in Worst Occipital Pain 2 Weeks After the Start of Treatment

This outcome measures the change in the numeric pain scale score from baseline to 2 weeks after treatment. The scale ranges from 0-10. The minimum score is 0 which is defined as no pain and the maximum score is 10, which is defined as the worst pain imaginable. The best possible outcome would be a 0. The worst possible outcome would be a 10. (NCT01670825)
Timeframe: From baseline to 2 weeks after the start of treatment

Interventionunits on a scale (Mean)
Pulsed Radiofrequency + Local Anesthetic Injection4.726
Corticosteroid Injection + Sham Pulsed Radiofrequency5.846

Change in Worst Occipital Pain 3 Months After the Start of Treatment

This outcome measures the change in the numeric pain scale score from baseline to 3 months after treatment. The scale ranges from 0-10. The minimum score is 0 which is defined as no pain and the maximum score is 10, which is defined as the worst pain imaginable. The best possible outcome would be a 0. The worst possible outcome would be a 10. (NCT01670825)
Timeframe: From baseline to 3 months after the start of treatment

Interventionunits on a scale (Mean)
Pulsed Radiofrequency + Local Anesthetic Injection5.850
Corticosteroid Injection + Sham Pulsed Radiofrequency7.149

Change in Worst Occipital Pain 6 Months After the Start of Treatment

This outcome measures the change in the numeric pain scale score from baseline to 6 months after treatment. The scale ranges from 0-10. The minimum score is 0 which is defined as no pain and the maximum score is 10, which is defined as the worst pain imaginable. The best possible outcome would be a 0. The worst possible outcome would be a 10. (NCT01670825)
Timeframe: From baseline to 6 months after the start of treatment

Interventionunits on a scale (Mean)
Pulsed Radiofrequency + Local Anesthetic Injection6.705
Corticosteroid Injection + Sham Pulsed Radiofrequency7.541

Change in Worst Occipital Pain 6 Weeks After the Start of Treatment

The change in the numeric pain scale score from baseline to 6 weeks after treatment. The scale ranges from 0-10. The minimum score is 0 which is defined as no pain and the maximum score is 10, which is defined as the worst pain imaginable. The best possible outcome would be a 0. The worst possible outcome would be a 10. (NCT01670825)
Timeframe: From baseline to 6 weeks after the start of treatment

Interventionunits on a scale (Mean)
Pulsed Radiofrequency + Local Anesthetic Injection5.354
Corticosteroid Injection + Sham Pulsed Radiofrequency6.064

Disability Due to Headaches 3 Months After the Start of Treatment Measured Using the Headache Impact Scale

This outcome measures what the patient feels they cannot do because headaches. This outcome is measured using the Headache Impact Test. Scores in this test range from range from 36 to 78, with higher scores indicating greater negative impact. A score of less than 50 indicates minimal impact, while a score greater than or equal to 60 indicates headaches are severely impacting one's life. (NCT01670825)
Timeframe: From baseline to 3 months after the start of treatment

Interventionunits on a scale (Mean)
Pulsed Radiofrequency + Local Anesthetic Injection59.718
Corticosteroid Injection + Sham Pulsed Radiofrequency60.556

Disability Due to Headaches 6 Months After the Start of Treatment Measured Using the Headache Impact Scale

This outcome measures what the patient feels they cannot do because headaches. This outcome is measured using the Headache Impact Test. Scores in this test range from range from 36 to 78, with higher scores indicating greater negative impact. A score of less than 50 indicates minimal impact, while a score greater than or equal to 60 indicates headaches are severely impacting one's life. (NCT01670825)
Timeframe: From baseline to 6 months after the start of treatment

Interventionunits on a scale (Mean)
Pulsed Radiofrequency + Local Anesthetic Injection59.641
Corticosteroid Injection + Sham Pulsed Radiofrequency61.389

Disability Due to Headaches 6 Weeks After the Start of Treatment Measured Using the Headache Impact Scale

This outcome measures what the patient feels they cannot do because headaches. This outcome is measured using the Headache Impact Test. Scores in this test range from range from 36 to 78, with higher scores indicating greater negative impact. A score of less than 50 indicates minimal impact, while a score greater than or equal to 60 indicates headaches are severely impacting one's life. (NCT01670825)
Timeframe: From baseline to 6 weeks after the start of treatment

Interventionunits on a scale (Mean)
Pulsed Radiofrequency + Local Anesthetic Injection60.087
Corticosteroid Injection + Sham Pulsed Radiofrequency59.553

Severe Headache Frequency for Migraine Headaches 3 Months After the Start of Treatment Measured Asking the Number of Severe Headache Days 1 Week Prior to Study Visit

This outcome will measure the number of days the patient has severe migraine headaches in the week (7 days) prior to the 3 month follow-up visit. A severe headache is defined as a headache with a score greater than or equal to 7 on the numeric pain scale. (NCT01670825)
Timeframe: From baseline to 3 months after the start of treatment

Interventiondays (Mean)
Pulsed Radiofrequency + Local Anesthetic Injection2.087
Corticosteroid Injection + Sham Pulsed Radiofrequency2.263

Severe Headache Frequency for Migraine Headaches 6 Months After the Start of Treatment Measured Asking the Number of Severe Headache Days 1 Week Prior to Study Visit

This outcome will measure the number of days the patient has severe migraine headaches in the week (7 days) prior to the 6 month follow-up visit. A severe headache is defined as a headache with a score greater than or equal to 7 on the numeric pain scale. (NCT01670825)
Timeframe: From baseline to 6 months after the start of treatment

Interventiondays (Mean)
Pulsed Radiofrequency + Local Anesthetic Injection2.044
Corticosteroid Injection + Sham Pulsed Radiofrequency2.368

Severe Headache Frequency for Migraine Headaches 6 Weeks After the Start of Treatment Measured Asking the Number of Severe Headaches in the Past Week.

This outcome will measure the number of days the patient has severe migraine headaches in the week (7 days) prior to the 6 week follow-up visit. A severe headache is defined as a headache with a score greater than or equal to 7 on the numeric pain scale. (NCT01670825)
Timeframe: From baseline to 6 weeks after the start of treatment

Interventiondays (Mean)
Pulsed Radiofrequency + Local Anesthetic Injection1.708
Corticosteroid Injection + Sham Pulsed Radiofrequency1.810

Severe Headache Frequency for Occipital Neuralgia Headaches 3 Months After the Start of Treatment Measured Asking the Number of Severe Headache Days 1 Week Prior to Study Visit

This outcome will measure the number of days the patient has severe occipital neuralgia headaches in the week (7 days) prior to the 6 week follow-up visit. A severe headache is defined as a headache with a score greater than or equal to 7 on the numeric pain scale. (NCT01670825)
Timeframe: 3 months

Interventiondays (Mean)
Pulsed Radiofrequency + Local Anesthetic Injection1.846
Corticosteroid Injection + Sham Pulsed Radiofrequency1.919

Severe Headache Frequency for Occipital Neuralgia Headaches 6 Months After the Start of Treatment Measured Asking the Number of Severe Headache Days 1 Week Prior to Study Visit

This outcome will measure the number of days the patient has severe occipital neuralgia headaches in the week (7 days) prior to the 6 week follow-up visit. A severe headache is defined as a headache with a score greater than or equal to 7 on the numeric pain scale. (NCT01670825)
Timeframe: From baseline to 6 months after the start of treatment

Interventiondays (Mean)
Pulsed Radiofrequency + Local Anesthetic Injection2.128
Corticosteroid Injection + Sham Pulsed Radiofrequency2.162

Severe Headache Frequency for Occipital Neuralgia Headaches 6 Weeks After the Start of Treatment Measured Asking the Number of Severe Headache Days 1 Week Prior to Study Visit

This outcome will measure the number of days the patient has severe occipital neuralgia headaches in the week (7 days) prior to the 6 week follow-up visit. A severe headache is defined as a headache with a score greater than or equal to 7 on the numeric pain scale. (NCT01670825)
Timeframe: From baseline to 6 weeks after the start of treatment

Interventiondays (Mean)
Pulsed Radiofrequency + Local Anesthetic Injection1.436
Corticosteroid Injection + Sham Pulsed Radiofrequency1.436

Trials

7 trials available for bupivacaine and Neuralgia

ArticleYear
Randomized, double-blind, comparative-effectiveness study comparing pulsed radiofrequency to steroid injections for occipital neuralgia or migraine with occipital nerve tenderness.
    Pain, 2015, Volume: 156, Issue:12

    Topics: Adult; Anesthetics, Local; Bupivacaine; Delayed-Action Preparations; Double-Blind Method; Drug Thera

2015
Randomized, double-blind, comparative-effectiveness study comparing pulsed radiofrequency to steroid injections for occipital neuralgia or migraine with occipital nerve tenderness.
    Pain, 2015, Volume: 156, Issue:12

    Topics: Adult; Anesthetics, Local; Bupivacaine; Delayed-Action Preparations; Double-Blind Method; Drug Thera

2015
Randomized, double-blind, comparative-effectiveness study comparing pulsed radiofrequency to steroid injections for occipital neuralgia or migraine with occipital nerve tenderness.
    Pain, 2015, Volume: 156, Issue:12

    Topics: Adult; Anesthetics, Local; Bupivacaine; Delayed-Action Preparations; Double-Blind Method; Drug Thera

2015
Randomized, double-blind, comparative-effectiveness study comparing pulsed radiofrequency to steroid injections for occipital neuralgia or migraine with occipital nerve tenderness.
    Pain, 2015, Volume: 156, Issue:12

    Topics: Adult; Anesthetics, Local; Bupivacaine; Delayed-Action Preparations; Double-Blind Method; Drug Thera

2015
Randomized, double-blind, comparative-effectiveness study comparing pulsed radiofrequency to steroid injections for occipital neuralgia or migraine with occipital nerve tenderness.
    Pain, 2015, Volume: 156, Issue:12

    Topics: Adult; Anesthetics, Local; Bupivacaine; Delayed-Action Preparations; Double-Blind Method; Drug Thera

2015
Randomized, double-blind, comparative-effectiveness study comparing pulsed radiofrequency to steroid injections for occipital neuralgia or migraine with occipital nerve tenderness.
    Pain, 2015, Volume: 156, Issue:12

    Topics: Adult; Anesthetics, Local; Bupivacaine; Delayed-Action Preparations; Double-Blind Method; Drug Thera

2015
Randomized, double-blind, comparative-effectiveness study comparing pulsed radiofrequency to steroid injections for occipital neuralgia or migraine with occipital nerve tenderness.
    Pain, 2015, Volume: 156, Issue:12

    Topics: Adult; Anesthetics, Local; Bupivacaine; Delayed-Action Preparations; Double-Blind Method; Drug Thera

2015
Randomized, double-blind, comparative-effectiveness study comparing pulsed radiofrequency to steroid injections for occipital neuralgia or migraine with occipital nerve tenderness.
    Pain, 2015, Volume: 156, Issue:12

    Topics: Adult; Anesthetics, Local; Bupivacaine; Delayed-Action Preparations; Double-Blind Method; Drug Thera

2015
Randomized, double-blind, comparative-effectiveness study comparing pulsed radiofrequency to steroid injections for occipital neuralgia or migraine with occipital nerve tenderness.
    Pain, 2015, Volume: 156, Issue:12

    Topics: Adult; Anesthetics, Local; Bupivacaine; Delayed-Action Preparations; Double-Blind Method; Drug Thera

2015
Randomized, double-blind, comparative-effectiveness study comparing pulsed radiofrequency to steroid injections for occipital neuralgia or migraine with occipital nerve tenderness.
    Pain, 2015, Volume: 156, Issue:12

    Topics: Adult; Anesthetics, Local; Bupivacaine; Delayed-Action Preparations; Double-Blind Method; Drug Thera

2015
Randomized, double-blind, comparative-effectiveness study comparing pulsed radiofrequency to steroid injections for occipital neuralgia or migraine with occipital nerve tenderness.
    Pain, 2015, Volume: 156, Issue:12

    Topics: Adult; Anesthetics, Local; Bupivacaine; Delayed-Action Preparations; Double-Blind Method; Drug Thera

2015
Randomized, double-blind, comparative-effectiveness study comparing pulsed radiofrequency to steroid injections for occipital neuralgia or migraine with occipital nerve tenderness.
    Pain, 2015, Volume: 156, Issue:12

    Topics: Adult; Anesthetics, Local; Bupivacaine; Delayed-Action Preparations; Double-Blind Method; Drug Thera

2015
Randomized, double-blind, comparative-effectiveness study comparing pulsed radiofrequency to steroid injections for occipital neuralgia or migraine with occipital nerve tenderness.
    Pain, 2015, Volume: 156, Issue:12

    Topics: Adult; Anesthetics, Local; Bupivacaine; Delayed-Action Preparations; Double-Blind Method; Drug Thera

2015
Randomized, double-blind, comparative-effectiveness study comparing pulsed radiofrequency to steroid injections for occipital neuralgia or migraine with occipital nerve tenderness.
    Pain, 2015, Volume: 156, Issue:12

    Topics: Adult; Anesthetics, Local; Bupivacaine; Delayed-Action Preparations; Double-Blind Method; Drug Thera

2015
Randomized, double-blind, comparative-effectiveness study comparing pulsed radiofrequency to steroid injections for occipital neuralgia or migraine with occipital nerve tenderness.
    Pain, 2015, Volume: 156, Issue:12

    Topics: Adult; Anesthetics, Local; Bupivacaine; Delayed-Action Preparations; Double-Blind Method; Drug Thera

2015
Randomized, double-blind, comparative-effectiveness study comparing pulsed radiofrequency to steroid injections for occipital neuralgia or migraine with occipital nerve tenderness.
    Pain, 2015, Volume: 156, Issue:12

    Topics: Adult; Anesthetics, Local; Bupivacaine; Delayed-Action Preparations; Double-Blind Method; Drug Thera

2015
Randomized, double-blind, comparative-effectiveness study comparing pulsed radiofrequency to steroid injections for occipital neuralgia or migraine with occipital nerve tenderness.
    Pain, 2015, Volume: 156, Issue:12

    Topics: Adult; Anesthetics, Local; Bupivacaine; Delayed-Action Preparations; Double-Blind Method; Drug Thera

2015
Randomized, double-blind, comparative-effectiveness study comparing pulsed radiofrequency to steroid injections for occipital neuralgia or migraine with occipital nerve tenderness.
    Pain, 2015, Volume: 156, Issue:12

    Topics: Adult; Anesthetics, Local; Bupivacaine; Delayed-Action Preparations; Double-Blind Method; Drug Thera

2015
Randomized, double-blind, comparative-effectiveness study comparing pulsed radiofrequency to steroid injections for occipital neuralgia or migraine with occipital nerve tenderness.
    Pain, 2015, Volume: 156, Issue:12

    Topics: Adult; Anesthetics, Local; Bupivacaine; Delayed-Action Preparations; Double-Blind Method; Drug Thera

2015
Randomized, double-blind, comparative-effectiveness study comparing pulsed radiofrequency to steroid injections for occipital neuralgia or migraine with occipital nerve tenderness.
    Pain, 2015, Volume: 156, Issue:12

    Topics: Adult; Anesthetics, Local; Bupivacaine; Delayed-Action Preparations; Double-Blind Method; Drug Thera

2015
Randomized, double-blind, comparative-effectiveness study comparing pulsed radiofrequency to steroid injections for occipital neuralgia or migraine with occipital nerve tenderness.
    Pain, 2015, Volume: 156, Issue:12

    Topics: Adult; Anesthetics, Local; Bupivacaine; Delayed-Action Preparations; Double-Blind Method; Drug Thera

2015
Randomized, double-blind, comparative-effectiveness study comparing pulsed radiofrequency to steroid injections for occipital neuralgia or migraine with occipital nerve tenderness.
    Pain, 2015, Volume: 156, Issue:12

    Topics: Adult; Anesthetics, Local; Bupivacaine; Delayed-Action Preparations; Double-Blind Method; Drug Thera

2015
Randomized, double-blind, comparative-effectiveness study comparing pulsed radiofrequency to steroid injections for occipital neuralgia or migraine with occipital nerve tenderness.
    Pain, 2015, Volume: 156, Issue:12

    Topics: Adult; Anesthetics, Local; Bupivacaine; Delayed-Action Preparations; Double-Blind Method; Drug Thera

2015
Randomized, double-blind, comparative-effectiveness study comparing pulsed radiofrequency to steroid injections for occipital neuralgia or migraine with occipital nerve tenderness.
    Pain, 2015, Volume: 156, Issue:12

    Topics: Adult; Anesthetics, Local; Bupivacaine; Delayed-Action Preparations; Double-Blind Method; Drug Thera

2015
Randomized, double-blind, comparative-effectiveness study comparing pulsed radiofrequency to steroid injections for occipital neuralgia or migraine with occipital nerve tenderness.
    Pain, 2015, Volume: 156, Issue:12

    Topics: Adult; Anesthetics, Local; Bupivacaine; Delayed-Action Preparations; Double-Blind Method; Drug Thera

2015
Study protocol for a pilot, randomised, double-blinded, placebo controlled trial of perineural local anaesthetics and steroids for chronic post-traumatic neuropathic pain in the ankle and foot: the PREPLANS study.
    BMJ open, 2016, 06-22, Volume: 6, Issue:6

    Topics: Anesthetics, Local; Ankle; Ankle Injuries; Bupivacaine; Chronic Pain; Double-Blind Method; Feasibili

2016
Treatment of ilioinguinal nerve entrapment - a randomized controlled trial.
    Acta obstetricia et gynecologica Scandinavica, 2011, Volume: 90, Issue:9

    Topics: Adult; Anesthetics, Local; Bupivacaine; Cross-Over Studies; Female; Humans; Middle Aged; Nerve Compr

2011
Effect of the addition of clonidine to locally administered bupivacaine on acute and chronic postmastectomy pain.
    Journal of clinical anesthesia, 2013, Volume: 25, Issue:1

    Topics: Acute Pain; Administration, Topical; Adult; Analgesics; Anesthetics, Local; Breast Neoplasms; Bupiva

2013
Comparison of epidural analgesia and intercostal nerve cryoanalgesia for post-thoracotomy pain control.
    European journal of pain (London, England), 2008, Volume: 12, Issue:3

    Topics: Aged; Analgesia; Analgesia, Epidural; Analgesics; Bupivacaine; Chronic Disease; Cryotherapy; Female;

2008
Comparison of epidural analgesia and intercostal nerve cryoanalgesia for post-thoracotomy pain control.
    European journal of pain (London, England), 2008, Volume: 12, Issue:3

    Topics: Aged; Analgesia; Analgesia, Epidural; Analgesics; Bupivacaine; Chronic Disease; Cryotherapy; Female;

2008
Comparison of epidural analgesia and intercostal nerve cryoanalgesia for post-thoracotomy pain control.
    European journal of pain (London, England), 2008, Volume: 12, Issue:3

    Topics: Aged; Analgesia; Analgesia, Epidural; Analgesics; Bupivacaine; Chronic Disease; Cryotherapy; Female;

2008
Comparison of epidural analgesia and intercostal nerve cryoanalgesia for post-thoracotomy pain control.
    European journal of pain (London, England), 2008, Volume: 12, Issue:3

    Topics: Aged; Analgesia; Analgesia, Epidural; Analgesics; Bupivacaine; Chronic Disease; Cryotherapy; Female;

2008
Comparison of epidural analgesia and intercostal nerve cryoanalgesia for post-thoracotomy pain control.
    European journal of pain (London, England), 2008, Volume: 12, Issue:3

    Topics: Aged; Analgesia; Analgesia, Epidural; Analgesics; Bupivacaine; Chronic Disease; Cryotherapy; Female;

2008
Comparison of epidural analgesia and intercostal nerve cryoanalgesia for post-thoracotomy pain control.
    European journal of pain (London, England), 2008, Volume: 12, Issue:3

    Topics: Aged; Analgesia; Analgesia, Epidural; Analgesics; Bupivacaine; Chronic Disease; Cryotherapy; Female;

2008
Comparison of epidural analgesia and intercostal nerve cryoanalgesia for post-thoracotomy pain control.
    European journal of pain (London, England), 2008, Volume: 12, Issue:3

    Topics: Aged; Analgesia; Analgesia, Epidural; Analgesics; Bupivacaine; Chronic Disease; Cryotherapy; Female;

2008
Comparison of epidural analgesia and intercostal nerve cryoanalgesia for post-thoracotomy pain control.
    European journal of pain (London, England), 2008, Volume: 12, Issue:3

    Topics: Aged; Analgesia; Analgesia, Epidural; Analgesics; Bupivacaine; Chronic Disease; Cryotherapy; Female;

2008
Comparison of epidural analgesia and intercostal nerve cryoanalgesia for post-thoracotomy pain control.
    European journal of pain (London, England), 2008, Volume: 12, Issue:3

    Topics: Aged; Analgesia; Analgesia, Epidural; Analgesics; Bupivacaine; Chronic Disease; Cryotherapy; Female;

2008
The effects of epidural blockade on the acute pain in herpes zoster.
    Archives of dermatology, 1999, Volume: 135, Issue:11

    Topics: Acute Disease; Acyclovir; Adult; Aged; Aged, 80 and over; Analgesia, Epidural; Analysis of Variance;

1999
Cerebrospinal norepinephrine concentrations and the duration of epidural analgesia.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1990, Volume: 37, Issue:8

    Topics: Analgesia, Epidural; Analysis of Variance; Anesthesia, Epidural; Bupivacaine; Female; Herniorrhaphy;

1990

Other Studies

58 other studies available for bupivacaine and Neuralgia

ArticleYear
Preventive Intrathecal Injection of Bupivacaine Alleviated Microglia Activation and Neuropathic Pain in a Rat Model of Chronic Constriction Injury.
    International journal of molecular sciences, 2022, Jun-28, Volume: 23, Issue:13

    Topics: Animals; Bupivacaine; Constriction; Crush Injuries; Cytokines; HMGB1 Protein; Hyperalgesia; Injectio

2022
Treatment of Ocular Neuralgia After Refractive Surgery With Bilateral Orbital Steroid and Anesthetic Injections.
    Journal of refractive surgery (Thorofare, N.J. : 1995), 2019, Aug-01, Volume: 35, Issue:8

    Topics: Anesthetics, Local; Bupivacaine; Eye Pain; Glucocorticoids; Humans; Injections, Intraocular; Male; N

2019
Management of neuropathic pain following traumatic brachial plexus injury with neurolysis and oral gabapentin: A case report.
    Nigerian journal of clinical practice, 2019, Volume: 22, Issue:9

    Topics: Adult; Aged; Analgesics; Brachial Plexus; Brachial Plexus Neuropathies; Bupivacaine; Gabapentin; Hum

2019
Case Report: Treatment of Refractory Post-Surgical Neuralgia With Erector Spinae Plane Block.
    Pain practice : the official journal of World Institute of Pain, 2020, Volume: 20, Issue:5

    Topics: Aged; Anesthetics, Local; Anti-Inflammatory Agents; Bupivacaine; Chronic Pain; Dexamethasone; Humans

2020
Ultrasound guided low thoracic erector spinae plane block for management of acute herpes zoster.
    Journal of clinical anesthesia, 2018, Volume: 45

    Topics: Aged; Anesthetics, Local; Bupivacaine; Herpes Zoster; Humans; Male; Nerve Block; Neuralgia; Pain Man

2018
Palliative care with cervical intrathecal infusion and external pump for a late-stage cancer patient with refractory pain: A case report.
    Medicine, 2018, Volume: 97, Issue:4

    Topics: Aged; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthetics, Local; Bupivacaine; Carcinoma,

2018
Atypical distribution of local anesthetic solution in a patient with distal adductor canal catheter.
    Journal of clinical anesthesia, 2018, Volume: 49

    Topics: Aged, 80 and over; Analgesia; Anesthesia, Local; Anesthetics, Local; Bupivacaine; Catheters; Foot; H

2018
Pain in the hand caused by a previously undescribed mechanism with possible relevance for understanding regional pain.
    Scandinavian journal of pain, 2018, 10-25, Volume: 18, Issue:4

    Topics: Acupuncture Points; Adult; Anesthetics, Local; Bupivacaine; Female; Hand; Humans; Injections, Intrav

2018
A new lacrimal neuralgia, a new nerve blockade procedure.
    Cephalalgia : an international journal of headache, 2014, Volume: 34, Issue:12

    Topics: Anesthetics, Local; Bupivacaine; Female; Humans; Lacrimal Apparatus Diseases; Middle Aged; Nerve Blo

2014
Effects of various antiepileptics used to alleviate neuropathic pain on compound action potential in frog sciatic nerves: comparison with those of local anesthetics.
    BioMed research international, 2014, Volume: 2014

    Topics: Action Potentials; Anesthetics, Local; Animals; Anticonvulsants; Bupivacaine; Carbamazepine; Humans;

2014
Nummular headache in a patient with ipsilateral occipital neuralgia--a case report.
    Neurologia i neurochirurgia polska, 2014, Volume: 48, Issue:2

    Topics: Amines; Analgesics; Anesthetics, Local; Bupivacaine; Comorbidity; Cyclohexanecarboxylic Acids; Femal

2014
Infratrochlear nerve block for a new infratrochlear neuralgia.
    Cephalalgia : an international journal of headache, 2016, Volume: 36, Issue:4

    Topics: Anesthetics, Local; Bupivacaine; Female; Humans; Middle Aged; Nerve Block; Neuralgia; Trochlear Nerv

2016
External Nasal Neuralgia: A Neuropathic Pain Within the Territory of the External Nasal Nerve.
    Headache, 2015, Volume: 55, Issue:9

    Topics: Aged; Anesthetics, Local; Bupivacaine; Female; Humans; Nerve Block; Neuralgia; Nose

2015
Conditioned place preference and spontaneous dorsal horn neuron activity in chronic constriction injury model in rats.
    Pain, 2015, Volume: 156, Issue:12

    Topics: Anesthetics, Local; Animals; Behavior, Animal; Bupivacaine; Conditioning, Psychological; Disease Mod

2015
Successful Management of Corneal Neuropathic Pain with Intrathecal Targeted Drug Delivery.
    Pain medicine (Malden, Mass.), 2016, Volume: 17, Issue:7

    Topics: Adult; Analgesics; Bupivacaine; Cervical Vertebrae; Cornea; Female; Fentanyl; Humans; Infusion Pumps

2016
Ultrasound Guided Intercostobrachial Nerve Blockade in Patients with Persistent Pain after Breast Cancer Surgery: A Pilot Study.
    Pain physician, 2016, Volume: 19, Issue:2

    Topics: Adult; Aged; Anesthetics, Local; Breast Neoplasms; Bupivacaine; Denmark; Double-Blind Method; Female

2016
Lacrimal Nerve Blocks for Three New Cases of Lacrimal Neuralgia.
    Headache, 2017, Volume: 57, Issue:3

    Topics: Adult; Anesthetics, Local; Bupivacaine; Female; Humans; Lacrimal Apparatus; Middle Aged; Nerve Block

2017
Early blockade of injured primary sensory afferents reduces glial cell activation in two rat neuropathic pain models.
    Neuroscience, 2009, Jun-02, Volume: 160, Issue:4

    Topics: Animals; Biomarkers; Bupivacaine; CD11b Antigen; Disease Models, Animal; Ganglia, Spinal; Glial Fibr

2009
Comparison of actions of systemically and locally administrated local anaesthetics in diabetic rats with painful neuropathy.
    Fundamental & clinical pharmacology, 2013, Volume: 27, Issue:2

    Topics: Anesthetics, Local; Animals; Bupivacaine; Diabetes Mellitus, Experimental; Disease Models, Animal; F

2013
Ultrasound-guided transversus abdominis plane catheter for chronic abdominal pain.
    Pain practice : the official journal of World Institute of Pain, 2013, Volume: 13, Issue:3

    Topics: Abdominal Muscles; Abdominal Pain; Abdominal Wall; Adolescent; Anesthetics, Local; Bupivacaine; Cath

2013
Radicular pain in post lumbar surgery syndrome: the significance of transforaminal injection of steroids.
    Pain medicine (Malden, Mass.), 2013, Volume: 14, Issue:2

    Topics: Adolescent; Adult; Aged; Anesthetics, Local; Anti-Inflammatory Agents; Bupivacaine; Drug Therapy, Co

2013
Chronic perineal pain caused by pudendal nerve entrapment: anatomy and CT-guided perineural injection technique.
    AJR. American journal of roentgenology, 2003, Volume: 181, Issue:2

    Topics: Adult; Aged; Anesthetics, Local; Bupivacaine; Chronic Disease; Glucocorticoids; Humans; Injections;

2003
Why CT-guided?
    AJR. American journal of roentgenology, 2004, Volume: 182, Issue:3

    Topics: Anesthetics, Local; Bupivacaine; Chronic Disease; Glucocorticoids; Humans; Injections; Methylprednis

2004
Severe ocular pain secondary to occipital neuralgia following vitrectomy surgery.
    Retina (Philadelphia, Pa.), 2004, Volume: 24, Issue:3

    Topics: Aged; Anesthetics, Local; Anti-Inflammatory Agents; Bupivacaine; Cranial Nerves; Female; Humans; Mal

2004
Sacral postherpetic neuralgia and successful treatment using a paramedial approach to the ganglion impar.
    Anesthesiology, 2004, Volume: 101, Issue:6

    Topics: Aged; Anesthetics, Local; Bupivacaine; Female; Ganglia, Sympathetic; Ganglionic Blockers; Herpes Zos

2004
Relief of pain in acute herpes zoster by nerve blocks and possible prevention of post-herpetic neuralgia.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2005, Volume: 52, Issue:2

    Topics: Aged; Anesthetics, Local; Anti-Inflammatory Agents; Bupivacaine; Epinephrine; Female; Herpes Zoster;

2005
Cervicogenic headache in patients with presumed migraine: missed diagnosis or misdiagnosis?
    The journal of pain, 2005, Volume: 6, Issue:10

    Topics: Adult; Aged; Anesthetics, Local; Bupivacaine; Cervical Plexus; Cervical Vertebrae; Chronic Disease;

2005
Nerve-stimulator-guided repeated pudendal nerve block for treatment of pudendal neuralgia.
    European journal of anaesthesiology, 2006, Volume: 23, Issue:5

    Topics: Analgesics; Analgesics, Opioid; Anesthetics, Local; Bupivacaine; Clonidine; Electric Stimulation; Ep

2006
Nerve conduction blockade in the sciatic nerve prevents but does not reverse the activation of p38 mitogen-activated protein kinase in spinal microglia in the rat spared nerve injury model.
    Anesthesiology, 2007, Volume: 107, Issue:2

    Topics: Anesthetics, Local; Animals; Behavior, Animal; Blotting, Western; Bupivacaine; Disease Models, Anima

2007
Re: characteristics and treatment of headache after traumatic brain injury.
    American journal of physical medicine & rehabilitation, 2007, Volume: 86, Issue:12

    Topics: Adrenal Cortex Hormones; Analgesics; Anesthetics, Local; Brain Injuries; Bupivacaine; Humans; Neural

2007
The effect of intra-neural local anaesthetic infusion on pain following major lower limb amputation.
    Scottish medical journal, 2008, Volume: 53, Issue:1

    Topics: Aged; Amputation, Surgical; Anesthesia, Local; Anesthetics, Local; Bupivacaine; Cohort Studies; Fema

2008
Intercostal nerve block.
    Australian family physician, 1984, Volume: 13, Issue:12

    Topics: Anesthesia, Local; Anesthetics; Bupivacaine; Humans; Intercostal Nerves; Nerve Block; Neuralgia; Pal

1984
Pain relief in herpes zoster.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1983, May-21, Volume: 63, Issue:21

    Topics: Adolescent; Adult; Aged; Analgesics; Bupivacaine; Drug Combinations; Female; Herpes Zoster; Humans;

1983
Facial causalgia: report of case.
    Journal of oral surgery (American Dental Association : 1965), 1980, Volume: 38, Issue:10

    Topics: Bupivacaine; Causalgia; Facial Nerve; Ganglia, Sympathetic; Humans; Male; Middle Aged; Nerve Block;

1980
Occipital neuralgia in a football player: a case report.
    Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine, 1995, Volume: 5, Issue:4

    Topics: Adult; Anesthetics, Local; Bupivacaine; Cervical Plexus; Diagnosis, Differential; Football; Headache

1995
A thermographic study of paravertebral analgesia.
    Anaesthesia, 1995, Volume: 50, Issue:2

    Topics: Adult; Aged; Autonomic Nerve Block; Blood Pressure; Body Temperature; Bupivacaine; Chronic Disease;

1995
A thermographic study of paravertebral analgesia.
    Anaesthesia, 1995, Volume: 50, Issue:2

    Topics: Adult; Aged; Autonomic Nerve Block; Blood Pressure; Body Temperature; Bupivacaine; Chronic Disease;

1995
A thermographic study of paravertebral analgesia.
    Anaesthesia, 1995, Volume: 50, Issue:2

    Topics: Adult; Aged; Autonomic Nerve Block; Blood Pressure; Body Temperature; Bupivacaine; Chronic Disease;

1995
A thermographic study of paravertebral analgesia.
    Anaesthesia, 1995, Volume: 50, Issue:2

    Topics: Adult; Aged; Autonomic Nerve Block; Blood Pressure; Body Temperature; Bupivacaine; Chronic Disease;

1995
A thermographic study of paravertebral analgesia.
    Anaesthesia, 1995, Volume: 50, Issue:2

    Topics: Adult; Aged; Autonomic Nerve Block; Blood Pressure; Body Temperature; Bupivacaine; Chronic Disease;

1995
A thermographic study of paravertebral analgesia.
    Anaesthesia, 1995, Volume: 50, Issue:2

    Topics: Adult; Aged; Autonomic Nerve Block; Blood Pressure; Body Temperature; Bupivacaine; Chronic Disease;

1995
A thermographic study of paravertebral analgesia.
    Anaesthesia, 1995, Volume: 50, Issue:2

    Topics: Adult; Aged; Autonomic Nerve Block; Blood Pressure; Body Temperature; Bupivacaine; Chronic Disease;

1995
A thermographic study of paravertebral analgesia.
    Anaesthesia, 1995, Volume: 50, Issue:2

    Topics: Adult; Aged; Autonomic Nerve Block; Blood Pressure; Body Temperature; Bupivacaine; Chronic Disease;

1995
A thermographic study of paravertebral analgesia.
    Anaesthesia, 1995, Volume: 50, Issue:2

    Topics: Adult; Aged; Autonomic Nerve Block; Blood Pressure; Body Temperature; Bupivacaine; Chronic Disease;

1995
A thermographic study of paravertebral analgesia.
    Anaesthesia, 1995, Volume: 50, Issue:2

    Topics: Adult; Aged; Autonomic Nerve Block; Blood Pressure; Body Temperature; Bupivacaine; Chronic Disease;

1995
A thermographic study of paravertebral analgesia.
    Anaesthesia, 1995, Volume: 50, Issue:2

    Topics: Adult; Aged; Autonomic Nerve Block; Blood Pressure; Body Temperature; Bupivacaine; Chronic Disease;

1995
A thermographic study of paravertebral analgesia.
    Anaesthesia, 1995, Volume: 50, Issue:2

    Topics: Adult; Aged; Autonomic Nerve Block; Blood Pressure; Body Temperature; Bupivacaine; Chronic Disease;

1995
A thermographic study of paravertebral analgesia.
    Anaesthesia, 1995, Volume: 50, Issue:2

    Topics: Adult; Aged; Autonomic Nerve Block; Blood Pressure; Body Temperature; Bupivacaine; Chronic Disease;

1995
A thermographic study of paravertebral analgesia.
    Anaesthesia, 1995, Volume: 50, Issue:2

    Topics: Adult; Aged; Autonomic Nerve Block; Blood Pressure; Body Temperature; Bupivacaine; Chronic Disease;

1995
A thermographic study of paravertebral analgesia.
    Anaesthesia, 1995, Volume: 50, Issue:2

    Topics: Adult; Aged; Autonomic Nerve Block; Blood Pressure; Body Temperature; Bupivacaine; Chronic Disease;

1995
A thermographic study of paravertebral analgesia.
    Anaesthesia, 1995, Volume: 50, Issue:2

    Topics: Adult; Aged; Autonomic Nerve Block; Blood Pressure; Body Temperature; Bupivacaine; Chronic Disease;

1995
Long-term epidural analgesia for pregnancy-induced intercostal neuralgia.
    Pain, 1995, Volume: 62, Issue:2

    Topics: Adult; Analgesia, Epidural; Bupivacaine; Female; Gestational Age; Humans; Intercostal Nerves; Neural

1995
[Epidural anesthesia in the treatment of painful diabetic neuropathy].
    Duodecim; laaketieteellinen aikakauskirja, 1995, Volume: 111, Issue:3

    Topics: Aged; Anesthesia, Epidural; Bupivacaine; Diabetic Neuropathies; Female; Humans; Leg; Neuralgia

1995
Epidural coadministration of ketamine, morphine and bupivacaine attenuates post-herpetic neuralgia--a case report.
    Acta anaesthesiologica Sinica, 1996, Volume: 34, Issue:3

    Topics: Adult; Analgesia, Epidural; Bupivacaine; Drug Therapy, Combination; Herpes Zoster; Humans; Ketamine;

1996
Long-term epidural ketamine, morphine and bupivacaine attenuate reflex sympathetic dystrophy neuralgia.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1998, Volume: 45, Issue:2

    Topics: Adult; Analgesia, Epidural; Analgesics, Opioid; Anesthetics, Local; Bupivacaine; Excitatory Amino Ac

1998
Another cause for transient radicular pain.
    Acta anaesthesiologica Scandinavica, 1999, Volume: 43, Issue:1

    Topics: Anesthetics, Local; Back Pain; Bupivacaine; Exanthema; Female; Herpes Genitalis; Humans; Nerve Block

1999
Urgent local anaesthetic drug alarm.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1999, Volume: 89, Issue:6

    Topics: Adolescent; Adult; Anesthetics, Local; Bupivacaine; Fat Necrosis; Female; Humans; Male; Mydriasis; N

1999
Transient neurologic symptoms after epidural analgesia in a five-year-old child.
    Anesthesia and analgesia, 2000, Volume: 91, Issue:4

    Topics: Acetaminophen; Analgesia, Epidural; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthesia, Epidur

2000
The effects of famciclovir and epidural block in the treatment of herpes zoster.
    The Journal of dermatology, 2001, Volume: 28, Issue:4

    Topics: 2-Aminopurine; Acyclovir; Adult; Analgesia, Epidural; Analysis of Variance; Anesthetics, Local; Anti

2001
Drug-induced liver disease during continuous epidural block with bupivacaine.
    Anesthesiology, 2001, Volume: 95, Issue:1

    Topics: Aged; Aged, 80 and over; Analgesia, Epidural; Anesthetics, Local; Bupivacaine; Chemical and Drug Ind

2001
[Usefulness of epidural administration of ketamine for relief of postherpetic neuralgia].
    Masui. The Japanese journal of anesthesiology, 2001, Volume: 50, Issue:8

    Topics: Aged; Analgesia, Epidural; Bupivacaine; Drug Therapy, Combination; Female; Herpes Zoster; Humans; In

2001
Inefficacy of high-dose transdermal fentanyl in a patient with neuropathic pain, a case report.
    European journal of pain (London, England), 2001, Volume: 5, Issue:3

    Topics: Administration, Cutaneous; Analgesia, Epidural; Analgesics, Opioid; Anesthetics, Local; Breast Neopl

2001
Epidural injection of local anesthetic and steroids for relief of pain secondary to herpes zoster.
    Archives of surgery (Chicago, Ill. : 1960), 1978, Volume: 113, Issue:3

    Topics: Adult; Aged; Anesthesia, Epidural; Bupivacaine; Drug Therapy, Combination; Herpes Zoster; Humans; In

1978
Chronic headache resulting from postoperative supraorbital neuralgia.
    Anesthesia and analgesia, 1992, Volume: 74, Issue:6

    Topics: Bupivacaine; Chronic Disease; Headache; Humans; Nerve Block; Neuralgia; Orbit; Postoperative Complic

1992
Treatment for herpes zoster ophthalmicus: stellate ganglion block as a treatment for acute pain and prevention of postherpetic neuralgia.
    Annals of ophthalmology, 1991, Volume: 23, Issue:5

    Topics: Acute Disease; Aged; Aged, 80 and over; Autonomic Nerve Block; Bupivacaine; Female; Herpes Zoster Op

1991
Chronic headache resulting from postoperative supraorbital neuralgia.
    Anesthesia and analgesia, 1991, Volume: 73, Issue:4

    Topics: Bupivacaine; Chronic Disease; Clonazepam; Female; Headache; Humans; Middle Aged; Nerve Block; Neural

1991
Local anaesthetic block therapy of posttraumatic neuralgia of the infraorbital nerve.
    Rhinology, 1990, Volume: 28, Issue:2

    Topics: Adult; Antidepressive Agents, Tricyclic; Bupivacaine; Cranial Nerve Diseases; Female; Humans; Male;

1990
Poststernotomy neuralgia: a new pain syndrome.
    Anesthesia and analgesia, 1989, Volume: 69, Issue:1

    Topics: Adult; Aged; Bupivacaine; Cicatrix; Ethanol; Humans; Intercostal Nerves; Male; Middle Aged; Nerve Bl

1989
Horner's syndrome after intrapleural anesthesia with bupivacaine for post-herpetic neuralgia.
    Acta anaesthesiologica Scandinavica, 1988, Volume: 32, Issue:7

    Topics: Aged; Bupivacaine; Female; Herpes Zoster; Horner Syndrome; Humans; Injections; Neuralgia; Pleura

1988
Nerve blocks utilizing 0.5% bupivacaine in the treatment of post-herpetic neuralgia.
    The Journal of the Kentucky Medical Association, 1987, Volume: 85, Issue:1

    Topics: Adult; Aged; Bupivacaine; Female; Herpes Zoster; Humans; Male; Middle Aged; Nerve Block; Neuralgia

1987
[Perivasal anesthetic infiltration as a simple method for peripheral sympathetic blockade in pain states of the extremities (sympathalgias)].
    Zeitschrift fur arztliche Fortbildung, 1985, Volume: 79, Issue:2

    Topics: Afferent Pathways; Arm; Autonomic Nerve Block; Bupivacaine; Dose-Response Relationship, Drug; Humans

1985
Treatment of intractable pain by bupivacaine nerve-block.
    Lancet (London, England), 1971, Dec-25, Volume: 2, Issue:7739

    Topics: Aged; Analgesia; Anesthesia, Conduction; Anesthetics, Local; Bupivacaine; Female; Humans; Male; Midd

1971
Relieving pain in the terminally ill.
    Geriatrics, 1973, Volume: 28, Issue:7

    Topics: Administration, Oral; Alcohols; Anesthesia, Spinal; Antidepressive Agents; Autonomic Nerve Block; Bu

1973