bupivacaine and Nervous System Diseases studies

Bupivacaine: A widely used local anesthetic agent.
1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide : A piperidinecarboxamide obtained by formal condensation of the carboxy group of N-butylpipecolic acid with the amino group of 2,6-dimethylaniline.
bupivacaine : A racemate composed of equimolar amounts of dextrobupivacaine and levobupivacaine. Used (in the form of its hydrochloride hydrate) as a local anaesthetic.

Nervous System Diseases: Diseases of the central and peripheral nervous system. This includes disorders of the brain, spinal cord, cranial nerves, peripheral nerves, nerve roots, autonomic nervous system, neuromuscular junction, and muscle.

Research Excerpts

Excerpt	Relevance	Reference
"5-year-old child with Cornelia de Lange syndrome presenting for orchidopexy and herniotomy received general anaesthesia which was supplemented by a caudal injection of bupivacaine."	3.67	Respiratory arrest after a caudal injection of bupivacaine. ( Carli, F; Lumb, AB, 1989)
"Monitoring for pain, sedation, postoperative nausea/vomiting, dizziness, and pruritus was performed by anesthesiologists blinded to the study allocation."	2.71	Caudal additives in pediatrics: a comparison among midazolam, ketamine, and neostigmine coadministered with bupivacaine. ( Acharya, A; Kumar, P; Pan, AK; Rudra, A, 2005)
"Prilocaine is an amide local anesthetic with a duration of action similar to that of lidocaine."	2.69	Transient neurologic symptoms after spinal anesthesia: a lower incidence with prilocaine and bupivacaine than with lidocaine. ( Drasner, K; Hampl, KF; Harms, C; Heinzmann-Wiedmer, S; Luginbuehl, I; Schneider, MC; Seeberger, M, 1998)
"Bupivacaine 3."	1.37	Spinal anesthesia in infant rats: development of a model and assessment of neurologic outcomes. ( Athiraman, U; Berde, CB; Carpino, EA; Corfas, G; Soriano, SG; Yahalom, B; Zurakowski, D, 2011)
" Five patients showed symptoms of compression of the cauda equina or spinal cord shortly after the start of combined IT administration of morphine and bupivacaine in a dosage usually not associated with neurologic symptoms."	1.30	Neurological impairment during long-term intrathecal infusion of bupivacaine in cancer patients: a sign of spinal cord compression. ( Crul, BJ; van Dongen, RT; van Ee, R, 1997)
"Thrombocytopenia is considered a relative contraindication to the administration of regional anesthesia."	1.30	Safe epidural analgesia in thirty parturients with platelet counts between 69,000 and 98,000 mm(-3). ( Beilin, Y; Comerford, M; Zahn, J, 1997)

Research

Studies (24)

Authors

Clinical Trials (3)

Trial Overview

Trial Outcomes

Olfactory Dysfunction Outcomes Rating (ODOR)

Timeframe	Studies, this research(%)	All Research%
pre-1990	8 (33.33)	18.7374
1990's	8 (33.33)	18.2507
2000's	6 (25.00)	29.6817
2010's	2 (8.33)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Park, AJ	1
Fisch, JM	1
Fisch, JL	1
Walters, MD	1
Lima, JE	1
Bianchin, MM	1
Marques, W	1
Yahalom, B	1
Athiraman, U	1
Soriano, SG	1
Zurakowski, D	1
Carpino, EA	1
Corfas, G	1
Berde, CB	1
Meyer, MJ	1
Krane, EJ	1
Goldschneider, KR	1
Klein, NJ	1
Treggiari, MM	1
Romand, JA	1
Martin, JB	1
Reverdin, A	1
Rüfenacht, DA	1
de Tribolet, N	1
Hernández-Palazón, J	1
Falcón-Araña, LF	1
García-Martínez, M	1
Kumar, P	1
Rudra, A	1
Pan, AK	1
Acharya, A	1
Neustein, SM	1
Nolte, H	1
Moore, DC	1
Spierdijk, J	1
vanKleef, JD	1
Coleman, RL	1
Love, GF	1
Chester, SC	1
Gutteridge, GA	1
van Dongen, RT	1
van Ee, R	1
Crul, BJ	1
Beilin, Y	1
Zahn, J	1
Comerford, M	1
Burgess, FW	1
Casati, A	1
Fanelli, G	1
Aldegheri, G	1
Berti, M	1
Leoni, A	1
Torri, G	1
Hampl, KF	1
Heinzmann-Wiedmer, S	1
Luginbuehl, I	1
Harms, C	1
Seeberger, M	1
Schneider, MC	1
Drasner, K	1
Simonneau, F	1
Vrillon, M	1
Westhues, M	1
Collier, CB	1
Kleiner, JB	1
Thorne, RP	1
Curd, JG	1
Lumb, AB	1
Carli, F	1
Pitkänen, M	1
Rosenberg, PH	1
Purcell-Jones, G	1
Justins, DM	1
Ashbell, TS	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Cervical Sympathetic Block to Increase Cerebral Blood Flow in Patients With Cerebral Vasospasm Following Aneurysmal Subarachnoid Hemorrhage[NCT05230134]		10 participants (Anticipated)	Interventional	2023-07-27	Enrolling by invitation
Stellate Ganglion Block for the Treatment of COVID-19-Induced Olfactory Dysfunction: A Prospective Pilot Study[NCT05445921]	Phase 1/Phase 2	20 participants (Actual)	Interventional	2022-09-01	Completed
Do Cervical Interlaminar Epidural Steroid Injections With Low-dose Lidocaine Cause Transient Objective Upper Extremity Weakness? A Prospective Randomized[NCT03382925]	Phase 4	16 participants (Actual)	Interventional	2017-12-20	Terminated (stopped due to Not enough cervical interlaminar patients who meet criteria in order to meet recruitment goals.)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

"Participants will be asked to complete the ODOR, which is a patient-reported outcome measure assessing physical problems, functional limitations, and emotional consequences of olfactory dysfunction.~The ODOR has a minimum score of 0 and a maximum score of 112 with higher scores indicating a greater degree of impairment and limitation. The minimal clinically important difference is a change of 15 points." (NCT05445921)
Timeframe: baseline, 5-10 days post SGB #1, and 1 month

University of Pennsylvania Smell Identification Test (UPSIT)

Intervention	score on a scale (Median)
	ODOR at Baseline	ODOR at 1 Week	ODOR at 1 Month
Stellate Ganglion Block	62	57	50.5

"Participants will complete the 40-item scratch and sniff UPSIT and mean change will be assessed.~The UPSIT has a minimum score of 0 and maximum score of 40 with lower scores indicating a greater degree of impairment. An UPSIT score of >33 for men and >34 for women is considered normosmic, and the minimal clinically important difference is a change of 4 points." (NCT05445921)
Timeframe: baseline, 5-10 days, and 1 month

Clinical Global Impression - Improvement (CGI-I) Score

Intervention	units on a scale (Median)
	UPSIT at Baseline	UPSIT at 1 Week	UPSIT at 1 Month
Stellate Ganglion Block	16.5	21	22.5

Participants will be asked about their change in olfactory dysfunction on a 7-point Likert scale from much better to much worse. (NCT05445921)
Timeframe: 5-10 days post SGB #1 and 1 month

Clinical Global Impression - Severity (CGI-S) Score

Intervention	Participants (Count of Participants)
	CGI-I for Smell Loss at 1 Week71922197	CGI-I for Smell Loss at 1 Month71922197	CGI-I for Smell Distortion at 1 Week71922197	CGI-I for Smell Distortion at 1 Month71922197	CGI-I for Taste Loss at 1 Week71922197	CGI-I for Taste Loss at 1 Month71922197	CGI-I for Taste Distortion at 1 Week71922197	CGI-I for Taste Distortion at 1 Month71922197
	About the Same	Slightly Better	Much Better	Moderately Better
Stellate Ganglion Block	8
Stellate Ganglion Block	10
Stellate Ganglion Block	9
Stellate Ganglion Block	11
Stellate Ganglion Block	6
Stellate Ganglion Block	1
Stellate Ganglion Block	15
Stellate Ganglion Block	4
Stellate Ganglion Block	0
Stellate Ganglion Block	14
Stellate Ganglion Block	3
Stellate Ganglion Block	2
Stellate Ganglion Block	13
Stellate Ganglion Block	12
Stellate Ganglion Block	5

Participants will be asked about the severity of their olfactory dysfunction (and gustatory dysfunction) on a 5-point Likert scale from no smell loss to severe smell loss. (NCT05445921)
Timeframe: baseline, 5-10 days, and 1 month

Article	Year
Cervical sympathetic block to reverse delayed ischemic neurological deficits after aneurysmal subarachnoid hemorrhage. Stroke, 2003, Volume: 34, Issue:4 Topics: Adult; Anesthetics, Local; Angiography, Digital Subtraction; Autonomic Nerve Block; Brain Ischemia;	2003
Cervical sympathetic block to reverse delayed ischemic neurological deficits after aneurysmal subarachnoid hemorrhage. Stroke, 2003, Volume: 34, Issue:4 Topics: Adult; Anesthetics, Local; Angiography, Digital Subtraction; Autonomic Nerve Block; Brain Ischemia;	2003
Cervical sympathetic block to reverse delayed ischemic neurological deficits after aneurysmal subarachnoid hemorrhage. Stroke, 2003, Volume: 34, Issue:4 Topics: Adult; Anesthetics, Local; Angiography, Digital Subtraction; Autonomic Nerve Block; Brain Ischemia;	2003
Cervical sympathetic block to reverse delayed ischemic neurological deficits after aneurysmal subarachnoid hemorrhage. Stroke, 2003, Volume: 34, Issue:4 Topics: Adult; Anesthetics, Local; Angiography, Digital Subtraction; Autonomic Nerve Block; Brain Ischemia;	2003
Caudal additives in pediatrics: a comparison among midazolam, ketamine, and neostigmine coadministered with bupivacaine. Anesthesia and analgesia, 2005, Volume: 101, Issue:1 Topics: Anesthesia Recovery Period; Anesthesia, Caudal; Anesthesia, General; Anesthetics, Intravenous; Anest	2005
Transient neurologic symptoms after spinal anesthesia: a lower incidence with prilocaine and bupivacaine than with lidocaine. Anesthesiology, 1998, Volume: 88, Issue:3 Topics: Adult; Anesthesia, Spinal; Anesthetics, Local; Bupivacaine; Female; Humans; Lidocaine; Nervous Syste	1998
Minor complications following anaesthesia in young adults for orthopaedic surgery of the lower extremity. Annales chirurgiae et gynaecologiae, 1987, Volume: 76, Issue:2 Topics: Adolescent; Adult; Anesthesia, General; Anesthesia, Spinal; Back Pain; Bupivacaine; Female; Headache	1987

Article	Year
Transient obturator neuropathy due to local anesthesia during transobturator sling placement. International urogynecology journal and pelvic floor dysfunction, 2009, Volume: 20, Issue:2 Topics: Adult; Anesthetics, Local; Bupivacaine; Female; Humans; Lidocaine; Nervous System Diseases; Obturato	2009
Permanent asymmetric neurologic deficits after spinal anesthesia with bupivacaine. Anesthesia and analgesia, 2009, Volume: 109, Issue:2 Topics: Anesthesia, Spinal; Anesthetics, Local; Bupivacaine; Dyskinesia, Drug-Induced; Humans; Male; Middle	2009
Spinal anesthesia in infant rats: development of a model and assessment of neurologic outcomes. Anesthesiology, 2011, Volume: 114, Issue:6 Topics: Anesthesia, Spinal; Animals; Animals, Newborn; Blood Gas Analysis; Bupivacaine; Disease Models, Anim	2011
Case report: neurological complications associated with epidural analgesia in children: a report of 4 cases of ambiguous etiologies. Anesthesia and analgesia, 2012, Volume: 115, Issue:6 Topics: Analgesia, Epidural; Anesthesia, General; Anesthetics, Local; Bupivacaine; Child; Colitis, Ulcerativ	2012
Transient postoperative neurologic deficit after lumbar laminectomy. Anesthesia and analgesia, 2003, Volume: 97, Issue:5 Topics: Adult; Anesthetics, Local; Bupivacaine; Diffusion; Humans; Intervertebral Disc Displacement; Laminec	2003
The use of lidocaine for spinal anesthesia. Anesthesia and analgesia, 2008, Volume: 106, Issue:5 Topics: Anesthesia, Spinal; Anesthetics, Local; Bupivacaine; Equipment Design; Health Knowledge, Attitudes,	2008
The role of spinal anesthesia today. Annales chirurgiae et gynaecologiae, 1984, Volume: 73, Issue:3 Topics: Anesthesia, Spinal; Bupivacaine; Headache; Humans; Intestinal Diseases; Muscular Diseases; Nerve Blo	1984
Chloroprocaine neurotoxicity: four additional cases. Anesthesia and analgesia, 1982, Volume: 61, Issue:2 Topics: Adult; Anesthesia, Epidural; Anesthesia, Spinal; Anesthetics, Local; Bupivacaine; Female; Humans; Ma	1982
Subtotal spinal anaesthesia as a complication of intrathoracic intercostal nerve blocks. Anaesthesia and intensive care, 1981, Volume: 9, Issue:4 Topics: Bupivacaine; Female; Humans; Intercostal Nerves; Middle Aged; Nerve Block; Nervous System Diseases;	1981
Neurological impairment during long-term intrathecal infusion of bupivacaine in cancer patients: a sign of spinal cord compression. Pain, 1997, Volume: 69, Issue:1-2 Topics: Aged; Analgesics, Opioid; Anesthetics, Local; Bupivacaine; Drug Combinations; Female; Humans; Inject	1997
Safe epidural analgesia in thirty parturients with platelet counts between 69,000 and 98,000 mm(-3). Anesthesia and analgesia, 1997, Volume: 85, Issue:2 Topics: Analgesia, Epidural; Analgesia, Obstetrical; Anesthesia, Epidural; Anesthesia, Obstetrical; Anesthet	1997
Masquerading neuropathies. Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1997, Volume: 44, Issue:10 Topics: Analgesia, Epidural; Anesthetics, Local; Bupivacaine; Humans; Nervous System Diseases; Postoperative	1997
A transient neurological deficit following intrathecal injection of 1% hyperbaric bupivacaine for unilateral spinal anaesthesia. European journal of anaesthesiology, 1998, Volume: 15, Issue:1 Topics: Adult; Anesthesia, Spinal; Anesthetics, Local; Bupivacaine; Humans; Injections, Spinal; Male; Nervou	1998
[Delayed neurological deficiency after spinal anesthesia in a patient with a history of lymphocytic meningitis]. Annales francaises d'anesthesie et de reanimation, 1997, Volume: 16, Issue:3 Topics: Anesthesia, Spinal; Anesthetics, Local; Bupivacaine; Humans; Male; Meningitis, Aseptic; Middle Aged;	1997
[Local anaesthesia--modern outlook, faults and complications (author's transl)]. Laryngologie, Rhinologie, Otologie, 1976, Volume: 55, Issue:4 Topics: Anesthesia, Local; Bupivacaine; Humans; Lidocaine; Mepivacaine; Nervous System Diseases; Procaine	1976
The value of bupivicaine hip injection in the differentiation of coxarthrosis from lower extremity neuropathy. The Journal of rheumatology, 1991, Volume: 18, Issue:3 Topics: Aged; Bupivacaine; Diagnosis, Differential; Female; Hip; Humans; Injections, Intra-Articular; Leg; M	1991
Respiratory arrest after a caudal injection of bupivacaine. Anaesthesia, 1989, Volume: 44, Issue:4 Topics: Anesthesia, Epidural; Bupivacaine; Child, Preschool; Cryptorchidism; De Lange Syndrome; Hernia, Ingu	1989
Delayed contralateral sympathetic blockade following chemical sympathectomy--a case history. Pain, 1988, Volume: 34, Issue:1 Topics: Adolescent; Autonomic Nerve Block; Bupivacaine; Central Nervous System; Extravasation of Diagnostic	1988
Neuropathy after bupivacaine block. The Journal of hand surgery, 1985, Volume: 10, Issue:1 Topics: Bupivacaine; Hand; Humans; Nerve Block; Nervous System Diseases; Time Factors; Tourniquets	1985

bupivacaine and Nervous System Diseases