bupivacaine has been researched along with Nerve Degeneration in 9 studies
Bupivacaine: A widely used local anesthetic agent.
1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide : A piperidinecarboxamide obtained by formal condensation of the carboxy group of N-butylpipecolic acid with the amino group of 2,6-dimethylaniline.
bupivacaine : A racemate composed of equimolar amounts of dextrobupivacaine and levobupivacaine. Used (in the form of its hydrochloride hydrate) as a local anaesthetic.
Nerve Degeneration: Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.
| Excerpt | Relevance | Reference |
|---|---|---|
| "There was "rebound hyperalgesia" to thermal stimulus after the resolution of plain bupivacaine sciatic nerve block." | 1.42 | Dexamethasone as adjuvant to bupivacaine prolongs the duration of thermal antinociception and prevents bupivacaine-induced rebound hyperalgesia via regional mechanism in a mouse sciatic nerve block model. ( An, K; Elkassabany, NM; Liu, J, 2015) |
| "0." | 1.27 | Experimental studies of the effect of bupivacaine on peripheral nerves. ( Helm, RH; Lee, YS; Pho, RW, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (44.44) | 18.7374 |
| 1990's | 1 (11.11) | 18.2507 |
| 2000's | 3 (33.33) | 29.6817 |
| 2010's | 1 (11.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| An, K | 1 |
| Elkassabany, NM | 1 |
| Liu, J | 1 |
| Gözil, R | 2 |
| Kurt, I | 2 |
| Erdoğan, D | 2 |
| Calgüner, E | 2 |
| Keskil, S | 2 |
| Kurt, MN | 1 |
| Elmas, C | 2 |
| Sabuncuoğlu, H | 1 |
| Sakura, S | 2 |
| Kirihara, Y | 1 |
| Muguruma, T | 1 |
| Kishimoto, T | 1 |
| Saito, Y | 1 |
| Bollen, AW | 1 |
| Ciriales, R | 1 |
| Drasner, K | 1 |
| Selander, D | 1 |
| Brattsand, R | 1 |
| Lundborg, G | 1 |
| Nordborg, C | 1 |
| Olsson, Y | 1 |
| Blunt, RJ | 1 |
| Vrbová, G | 1 |
| Tomas i Ferré, J | 1 |
| Fenoll i Brunet, R | 1 |
| Santafé, M | 1 |
| Mayayo, E | 1 |
| Helm, RH | 1 |
| Lee, YS | 1 |
| Pho, RW | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Comparative Study Between Dexamethasone, and Dexmedetomidine as Additives to Bupivacaine in Ultrasound Guided Adductor Canal Block in Knee Arthroscopy[NCT04631822] | 42 participants (Anticipated) | Interventional | 2021-01-01 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
9 other studies available for bupivacaine and Nerve Degeneration
| Article | Year |
|---|---|
Dexamethasone as adjuvant to bupivacaine prolongs the duration of thermal antinociception and prevents bupivacaine-induced rebound hyperalgesia via regional mechanism in a mouse sciatic nerve block model.
Topics: Anesthetics, Local; Animals; Axons; Bupivacaine; Chemotherapy, Adjuvant; Dexamethasone; Disease Mode | 2015 |
Long-term degeneration and regeneration of the rabbit facial nerve blocked with conventional lidocaine and bupivacaine solutions.
Topics: Anesthetics, Local; Animals; Bupivacaine; Facial Nerve; Lidocaine; Microscopy, Electron; Nerve Block | 2002 |
Atrophic and regenerative changes in rabbit mimic muscles after lidocaine and bupivacaine application.
Topics: Anesthetics, Local; Animals; Bupivacaine; Facial Nerve; Female; Lidocaine; Male; Muscle, Skeletal; M | 2003 |
The comparative neurotoxicity of intrathecal lidocaine and bupivacaine in rats.
Topics: Anesthetics, Local; Animals; Bupivacaine; Chemistry, Pharmaceutical; Dose-Response Relationship, Dru | 2005 |
Local anesthetic neurotoxicity does not result from blockade of voltage-gated sodium channels.
Topics: Animals; Bupivacaine; Demyelinating Diseases; Dose-Response Relationship, Drug; Injections, Spinal; | 1995 |
Local anesthetics: importance of mode of application, concentration and adrenaline for the appearance of nerve lesions. An experimental study of axonal degeneration and barrier damage after intrafascicular injection or topical application of bupivacaine (
Topics: Administration, Topical; Animals; Axons; Bupivacaine; Epinephrine; Injections; Microscopy, Fluoresce | 1979 |
The use of local anaesthetics to produce prolonged motor nerve block in the study of denervation hypersensitivity.
Topics: Acetylcholine; Animals; Bupivacaine; Hindlimb; Lidocaine; Muscle Contraction; Muscles; Myelin Sheath | 1975 |
Changes in motor nerve terminals during bupivacaine-induced postsynaptic deprivation.
Topics: Animals; Bupivacaine; Female; Male; Microscopy, Electron; Motor Neurons; Muscles; Nerve Degeneration | 1989 |
Experimental studies of the effect of bupivacaine on peripheral nerves.
Topics: Animals; Axons; Bupivacaine; Catheterization; Demyelinating Diseases; Nerve Degeneration; Rabbits; S | 1987 |