Page last updated: 2024-10-24

bupivacaine and Neoplasms

bupivacaine has been researched along with Neoplasms in 52 studies

Bupivacaine: A widely used local anesthetic agent.
1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide : A piperidinecarboxamide obtained by formal condensation of the carboxy group of N-butylpipecolic acid with the amino group of 2,6-dimethylaniline.
bupivacaine : A racemate composed of equimolar amounts of dextrobupivacaine and levobupivacaine. Used (in the form of its hydrochloride hydrate) as a local anaesthetic.

Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.

Research Excerpts

ExcerptRelevanceReference
" We included 14 patients aged 18 years and above, implanted with an Intrathecal Drug Delivery Systems (IDDS) for cancer pain treatment and followed up at ICO from July 2020 to February 2021 after switching from ropivacaine to bupivacaine."8.02First Evaluation Switching From Ropivacaine to Highly Concentrated Bupivacaine in Intrathecal Mixtures for Cancer Pain. ( Bellanger, M; Bienfait, F; Boré, F; Delorme, T; Dupoiron, D; Jaoul, V; Jubier-Hamon, S; Lebrec, N; Pluchon, YM; Robert, J; Seegers, V; Sorrieul, J, 2021)
"Fifteen patients with pain due to advanced cancer who no longer obtained relief from conventional treatment using oral or parenteral opioids were administered morphine and bupivacaine by continuous intrathecal infusion."7.69Intrathecal morphine and bupivacaine in advanced cancer pain patients implanted at home. ( Mercadante, S, 1994)
"In 53 patients, the clinical efficacy was estimated from: pain relief (visual analog scale scores 0-10); daily dosages (intrathecal and total opioid and intrathecal bupivacaine); scores (0-5) of nonopioid analgesic and sedative consumption, gait and daily activity, and amount of sleep; and rates of adverse effects."7.69Long-term intrathecal morphine and bupivacaine in patients with refractory cancer pain. Results from a morphine:bupivacaine dose regimen of 0.5:4.75 mg/ml. ( Appelgren, L; Curelaru, I; Nitescu, P; Sjöberg, M, 1994)
"Epidural or intrathecal infusions of morphine and bupivacaine mixtures are presently used for the treatment of "refractory" cancer pain even though the neurotoxic potential of such mixtures is unknown."7.68Neuropathologic findings after long-term intrathecal infusion of morphine and bupivacaine for pain treatment in cancer patients. ( Appelgren, L; Curelaru, I; Karlsson, PA; Linder, LE; Nitescu, P; Nordborg, C; Sjöberg, M; Wallgren, A, 1992)
" We included 14 patients aged 18 years and above, implanted with an Intrathecal Drug Delivery Systems (IDDS) for cancer pain treatment and followed up at ICO from July 2020 to February 2021 after switching from ropivacaine to bupivacaine."4.02First Evaluation Switching From Ropivacaine to Highly Concentrated Bupivacaine in Intrathecal Mixtures for Cancer Pain. ( Bellanger, M; Bienfait, F; Boré, F; Delorme, T; Dupoiron, D; Jaoul, V; Jubier-Hamon, S; Lebrec, N; Pluchon, YM; Robert, J; Seegers, V; Sorrieul, J, 2021)
"Fifteen patients with pain due to advanced cancer who no longer obtained relief from conventional treatment using oral or parenteral opioids were administered morphine and bupivacaine by continuous intrathecal infusion."3.69Intrathecal morphine and bupivacaine in advanced cancer pain patients implanted at home. ( Mercadante, S, 1994)
"In 53 patients, the clinical efficacy was estimated from: pain relief (visual analog scale scores 0-10); daily dosages (intrathecal and total opioid and intrathecal bupivacaine); scores (0-5) of nonopioid analgesic and sedative consumption, gait and daily activity, and amount of sleep; and rates of adverse effects."3.69Long-term intrathecal morphine and bupivacaine in patients with refractory cancer pain. Results from a morphine:bupivacaine dose regimen of 0.5:4.75 mg/ml. ( Appelgren, L; Curelaru, I; Nitescu, P; Sjöberg, M, 1994)
"Five children with cancer pain were given continuous intrathecal morphine or fentanyl infusion associated with bupivacaine 0."3.68[Intrathecal morphine therapy in children with cancer]. ( Ganansia, MF; Lejus, C; Meignier, M; Testa, S, 1992)
"Epidural or intrathecal infusions of morphine and bupivacaine mixtures are presently used for the treatment of "refractory" cancer pain even though the neurotoxic potential of such mixtures is unknown."3.68Neuropathologic findings after long-term intrathecal infusion of morphine and bupivacaine for pain treatment in cancer patients. ( Appelgren, L; Curelaru, I; Karlsson, PA; Linder, LE; Nitescu, P; Nordborg, C; Sjöberg, M; Wallgren, A, 1992)
"The role of epidural morphine in chronic cancer pain treatment is unresolved."3.68Epidural opiates and local anesthetics for the management of cancer pain. ( Abram, S; Haddox, DJ; Hogan, Q; Janjan, N; Taylor, ML; Weissman, D, 1991)
"Twenty patients with cancer were selected for intrathecal treatment because of either side effects or inadequate relief during conventional pain treatment."2.69Intrathecal coadministration of bupivacaine diminishes morphine dose progression during long-term intrathecal infusion in cancer patients. ( Crul, BJ; van Dongen, RT; van Egmond, J, 1999)
"Twenty-seven adults with cancer pain were prospectively selected according to their primary lesions and problems, but their allocation to study groups was randomized."2.67Prolongation of epidural bupivacaine analgesia with glycerin. ( King, H; Wooten, DJ; Xiao, CS, 1993)
"Up to 90% of patients with advanced cancer experience intractable pain."2.50Treatment of medically refractory cancer pain with a combination of intrathecal neuromodulation and neurosurgical ablation: case series and literature review. ( Bentley, JN; Patil, PG; Rosenberg, WS; Viswanathan, A, 2014)
" Chronic use of pain medications and older age were predictors of inadequate pain control postoperatively."1.48Factors Associated with Inadequate Pain Control among Postoperative Patients with Cancer. ( Al-Najar, M; Darawad, M; El-Aqoul, A; Obaid, A; Ramadan, M; Yacoub, E, 2018)
"A multidisciplinary interventional cancer pain service was established in the West of Scotland in 2008 with the aim of providing a safe and effective intrathecal drug delivery service for patients with difficult-to-control cancer pain."1.42Audit of intrathecal drug delivery for patients with difficult-to-control cancer pain shows a sustained reduction in pain severity scores over a 6-month period. ( McGhie, J; McGinn, G; Mitchell, A; Owen, M, 2015)
"Pain in terminal cancer patients may be refractory to systemic analgesics or associated with adverse drug reactions to analgesics."1.38Efficacy of epidural analgesia in patients with cancer pain: a retrospective observational study. ( Choi, JW; Jeon, YS; Joo, JD; Jung, HS; Kang, EG; Kim, HK; Lee, JA; Park, JH; Shim, BY, 2012)
"We present two cases of cancer patients with intractable mechanical and visceral pain that was unrelieved with either comprehensive medical management or intrathecal morphine who received intrathecal bupivacaine."1.32Efficacy of intrathecal bupivacaine: how important is the flow rate? ( Buchser, E; Chédel, D; Durrer, A; Mustaki, JP, 2004)
" Five patients showed symptoms of compression of the cauda equina or spinal cord shortly after the start of combined IT administration of morphine and bupivacaine in a dosage usually not associated with neurologic symptoms."1.30Neurological impairment during long-term intrathecal infusion of bupivacaine in cancer patients: a sign of spinal cord compression. ( Crul, BJ; van Dongen, RT; van Ee, R, 1997)
"As the number of terminal cancer patients receiving continuous intrathecal infusion of opioids and local anesthetics for relief of pain increases, we decided to investigate the post-mortem findings of the spinal cord, meninges and nerve roots of patients after continuous intrathecal administration of morphine and combined with bupivacaine."1.30Neurohistopathological findings after continuous intrathecal administration of morphine or a morphine/bupivacaine mixture in cancer pain patients. ( de Lange, JJ; Spoelder, EM; van der Valk, P; Wagemans, MF; Zuurmond, WW, 1997)
"We prospectively studied surgical cancer patients who received epidural bupivacaine-morphine to determine perioperative morphine use, side effects, and complications."1.29Postoperative epidural bupivacaine-morphine therapy. Experience with 4,227 surgical cancer patients. ( de Leon-Casasola, OA; Harrison, P; Lema, MJ; Massey, J; Parker, B, 1994)
" Bupivacaine-induced side effects were absent below a daily dosage of 30 mg by continuous infusion."1.29Long-term intrathecal infusion of morphine and morphine/bupivacaine mixtures in the treatment of cancer pain: a retrospective analysis of 51 cases. ( Crul, BJP; De Bock, M; Van Dongen, RTM, 1993)
"This study evaluated 20 chronic cancer pain patients who underwent abdominal surgery for tumor resection."1.29Epidural bupivacaine/sufentanil therapy for postoperative pain control in patients tolerant to opioid and unresponsive to epidural bupivacaine/morphine. ( de Leon-Casasola, OA; Lema, MJ, 1994)
" Thus, epidural BUP-MS appears to provide adequate postoperative analgesia while preventing withdrawal in opioid-dependent patients, if three times the normal dosage and duration of therapy are employed."1.29A comparison of postoperative epidural analgesia between patients with chronic cancer taking high doses of oral opioids versus opioid-naive patients. ( Bacon, DR; de Leon-Casasola, OA; Donaparthi, S; Lema, MJ; Myers, DP; Peppriell, J; Rempel, J, 1993)
"The treatment of severe cancer pain by intrathecal infusion of morphine and bupivacaine seems to be a promising method."1.29[Treatment of severe cancer pain via spinal catheters]. ( Andersen, JS; Markers, PI; Valentin, N, 1996)
" We conclude that epidural opioid-bupivacaine infusion is an effective and safe technique for long-term administration of analgesics in the refractory cancer patient."1.28Chronic epidural bupivacaine-opioid infusion in intractable cancer pain. ( Du Pen, SL; Hasche-Klunder, H; Kharasch, ED; Krembs, AW; Peterson, DG; Sloan, DC; Williams, A, 1992)
"Fifteen adult patients with cancer pain received 0."1.28[Epidural administration of bupivacaine in glycerine solution can prolong analgesia]. ( King, HK; Wooten, DJ; Xiao, CS, 1992)
" The efficacy of the treatment was estimated from: 1) daily dosage (intraspinal and total opiates, and intraspinal bupivacaine), and 2) scores of non-opiate analgesic and sedative consumption, gait and daily activities, and amount and pattern of sleep."1.28Long-term intrathecal morphine and bupivacaine in "refractory" cancer pain. I. Results from the first series of 52 patients. ( Appelgren, L; Curelaru, I; Einarsson, S; Hultman, E; Linder, LE; Nitescu, P; Sjöberg, M, 1991)

Research

Studies (52)

TimeframeStudies, this research(%)All Research%
pre-19907 (13.46)18.7374
1990's27 (51.92)18.2507
2000's6 (11.54)29.6817
2010's7 (13.46)24.3611
2020's5 (9.62)2.80

Authors

AuthorsStudies
Abdelemam, RM2
Fares, KM2
Kamal, SM1
Abdelghaffar, NA1
Farahat, TE1
Maharani, ND1
Fuadi, A1
Halimi, RA1
Mohamed, SA1
Abd El-Rahman, AM1
Osman, AMM1
Bienfait, F1
Jubier-Hamon, S1
Seegers, V1
Pluchon, YM1
Lebrec, N1
Jaoul, V1
Boré, F1
Delorme, T1
Robert, J1
Bellanger, M1
Sorrieul, J1
Dupoiron, D1
El-Aqoul, A1
Obaid, A1
Yacoub, E1
Al-Najar, M1
Ramadan, M1
Darawad, M1
De Andres, J1
Asensio-Samper, JM1
Fabregat-Cid, G1
Bentley, JN1
Viswanathan, A1
Rosenberg, WS1
Patil, PG1
Mitchell, A1
McGhie, J1
Owen, M1
McGinn, G1
Purdy, M1
Kärkkäinen, J1
Kokki, M1
Anttila, M1
Aspinen, S1
Juvonen, P1
Kokki, H1
Pulkki, K1
Rantanen, T1
Eskelinen, M1
Sato, C1
Okabe, T1
Nakanishi, K1
Sakamoto, A1
Jeon, YS1
Lee, JA1
Choi, JW1
Kang, EG1
Jung, HS1
Kim, HK1
Shim, BY1
Park, JH1
Joo, JD1
Breitfeld, C1
Eikermann, M1
Kienbaum, P1
Peters, J1
Mercadante, S4
Villari, P3
Ferrera, P3
Arcuri, E3
Buchser, E1
Durrer, A1
Chédel, D1
Mustaki, JP1
Baker, L1
Lee, M1
Regnard, C1
Crack, L1
Callin, S1
Mangione, S1
Mocavero, G1
Rinaldi, A1
Lotti, GG1
Bevilacqua, P1
Nitescu, P6
Sjöberg, M6
Appelgren, L6
Curelaru, I6
de Leon-Casasola, OA3
Parker, B1
Lema, MJ3
Harrison, P1
Massey, J1
Van Dongen, RTM1
Crul, BJP1
De Bock, M1
Samuelsson, H1
Ekman, R1
Hedner, T1
Myers, DP1
Donaparthi, S1
Bacon, DR1
Peppriell, J1
Rempel, J1
Jayr, C1
Thomas, H1
Rey, A1
Farhat, F1
Lasser, P1
Bourgain, JL1
King, H1
Xiao, CS2
Wooten, DJ2
Ricci, V1
Dalpane, A1
Lolli, E1
Andersen, JS1
Markers, PI1
Valentin, N1
van Dongen, RT2
van Ee, R1
Crul, BJ2
Wagemans, MF1
van der Valk, P1
Spoelder, EM1
Zuurmond, WW1
de Lange, JJ1
Antila, H1
Kirvelä, O1
Amesbury, B1
O'Riordan, J1
Dolin, S1
van Egmond, J1
Du Pen, SL2
Kharasch, ED1
Williams, A1
Peterson, DG1
Sloan, DC1
Hasche-Klunder, H1
Krembs, AW1
Meignier, M1
Ganansia, MF1
Lejus, C1
Testa, S1
de Jong, PC1
Kansen, PJ1
Williams, AR1
King, HK1
Karlsson, PA1
Nordborg, C1
Wallgren, A1
Linder, LE4
Hogan, Q1
Haddox, DJ1
Abram, S1
Weissman, D1
Taylor, ML1
Janjan, N1
Hultman, E3
Einarsson, S1
Hunt, R1
Massolino, J1
Sjøgren, P1
Gefke, K1
Banning, AM1
Parslov, M1
Overgaard Olsen, LB1
Moulin, DE1
Coyle, N1
Müller, H1
Biscoping, J1
Gips, H1
Tilkes, F1
Strunz, P1
Hempelmann, G1
Hannington-Kiff, JG1
Swerdlow, M1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Oxidative Stress and Inflammation Biomarkers in Correlation to Postoperative Pain Modulation in Surgically Treated Patients With Laryngeal Cancer[NCT05857202]100 participants (Anticipated)Observational2022-09-01Recruiting
Conscious Dying/Conscious Living: Ketamine-Assisted Psychotherapy (KAP) for Patients at End of Life-A Pilot Study for Palliative and Hospice Care[NCT05214417]Phase 2120 participants (Anticipated)Interventional2022-05-01Not yet recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

3 reviews available for bupivacaine and Neoplasms

ArticleYear
Intrathecal delivery of analgesics.
    Methods in molecular biology (Clifton, N.J.), 2014, Volume: 1141

    Topics: Analgesics, Opioid; Baclofen; Bupivacaine; Catheters, Indwelling; Chronic Pain; Clonidine; Drug Deli

2014
Intrathecal delivery of analgesics.
    Methods in molecular biology (Clifton, N.J.), 2014, Volume: 1141

    Topics: Analgesics, Opioid; Baclofen; Bupivacaine; Catheters, Indwelling; Chronic Pain; Clonidine; Drug Deli

2014
Treatment of medically refractory cancer pain with a combination of intrathecal neuromodulation and neurosurgical ablation: case series and literature review.
    Pain medicine (Malden, Mass.), 2014, Volume: 15, Issue:9

    Topics: Adolescent; Aged; Bone Neoplasms; Bupivacaine; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell

2014
Treatment of medically refractory cancer pain with a combination of intrathecal neuromodulation and neurosurgical ablation: case series and literature review.
    Pain medicine (Malden, Mass.), 2014, Volume: 15, Issue:9

    Topics: Adolescent; Aged; Bone Neoplasms; Bupivacaine; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell

2014
[Continuous spinal analgesia in home care of oncologic pain].
    Minerva medica, 1995, Volume: 86, Issue:10

    Topics: Analgesics, Opioid; Bupivacaine; Clonidine; Home Infusion Therapy; Humans; Infusion Pumps, Implantab

1995
[Continuous spinal analgesia in home care of oncologic pain].
    Minerva medica, 1995, Volume: 86, Issue:10

    Topics: Analgesics, Opioid; Bupivacaine; Clonidine; Home Infusion Therapy; Humans; Infusion Pumps, Implantab

1995

Trials

9 trials available for bupivacaine and Neoplasms

ArticleYear
Effect of Combined Epidural Morphine and Midazolam on Postoperative Pain in Patients Undergoing Major Abdominal Cancer Surgery.
    The Clinical journal of pain, 2022, 11-01, Volume: 38, Issue:11

    Topics: Analgesia, Epidural; Analgesics; Analgesics, Opioid; Anesthetics, Local; Bupivacaine; Double-Blind M

2022
Effect of Combined Epidural Morphine and Midazolam on Postoperative Pain in Patients Undergoing Major Abdominal Cancer Surgery.
    The Clinical journal of pain, 2022, 11-01, Volume: 38, Issue:11

    Topics: Analgesia, Epidural; Analgesics; Analgesics, Opioid; Anesthetics, Local; Bupivacaine; Double-Blind M

2022
Fluoroscopic anterior approach versus ultrasound guided superior hypogastric plexus neurolysis in cancer pelvic pain: a randomized controlled study.
    BMC anesthesiology, 2022, 12-27, Volume: 22, Issue:1

    Topics: Bupivacaine; Cancer Pain; Fluoroscopy; Humans; Hypogastric Plexus; Neoplasms; Nerve Block; Pelvic Pa

2022
Fluoroscopic anterior approach versus ultrasound guided superior hypogastric plexus neurolysis in cancer pelvic pain: a randomized controlled study.
    BMC anesthesiology, 2022, 12-27, Volume: 22, Issue:1

    Topics: Bupivacaine; Cancer Pain; Fluoroscopy; Humans; Hypogastric Plexus; Neoplasms; Nerve Block; Pelvic Pa

2022
Comparison of the effect of scalp block analgesia bupivacaine 0.25% and clonidine 2 μg/kg with bupivacaine 0.25% and dexamethasone 8 mg on cortisol levels and Numeric Rating Scale in craniotomy tumour.
    The Medical journal of Malaysia, 2023, Volume: 78, Issue:6

    Topics: Analgesia; Anesthetics, Local; Bupivacaine; Clonidine; Craniotomy; Dexamethasone; Humans; Hydrocorti

2023
Comparison of the effect of scalp block analgesia bupivacaine 0.25% and clonidine 2 μg/kg with bupivacaine 0.25% and dexamethasone 8 mg on cortisol levels and Numeric Rating Scale in craniotomy tumour.
    The Medical journal of Malaysia, 2023, Volume: 78, Issue:6

    Topics: Analgesia; Anesthetics, Local; Bupivacaine; Clonidine; Craniotomy; Dexamethasone; Humans; Hydrocorti

2023
Analgesic Effect of Intrathecal Fentanyl vs Dexmedetomidine as Adjuvants to Bupivacaine Following Abdominal Surgery for Cancer in Children, a Randomized Trial.
    Pain medicine (Malden, Mass.), 2020, 11-01, Volume: 21, Issue:11

    Topics: Analgesics; Anesthetics, Local; Bupivacaine; Child; Dexmedetomidine; Double-Blind Method; Fentanyl;

2020
Analgesic Effect of Intrathecal Fentanyl vs Dexmedetomidine as Adjuvants to Bupivacaine Following Abdominal Surgery for Cancer in Children, a Randomized Trial.
    Pain medicine (Malden, Mass.), 2020, 11-01, Volume: 21, Issue:11

    Topics: Analgesics; Anesthetics, Local; Bupivacaine; Child; Dexmedetomidine; Double-Blind Method; Fentanyl;

2020
Does Rectus Sheath Block Analgesia Alter Levels of the Oxidative Stress Biomarker Glutathione Peroxidase: A Randomised Trial of Patients with Cancer and Benign Disease.
    Anticancer research, 2017, Volume: 37, Issue:2

    Topics: Aged; Analgesia; Anesthetics, Local; Biomarkers; Bupivacaine; Disease; Female; Glutathione Peroxidas

2017
Does Rectus Sheath Block Analgesia Alter Levels of the Oxidative Stress Biomarker Glutathione Peroxidase: A Randomised Trial of Patients with Cancer and Benign Disease.
    Anticancer research, 2017, Volume: 37, Issue:2

    Topics: Aged; Analgesia; Anesthetics, Local; Biomarkers; Bupivacaine; Disease; Female; Glutathione Peroxidas

2017
Complications of intrathecal opioids and bupivacaine in the treatment of "refractory" cancer pain.
    The Clinical journal of pain, 1995, Volume: 11, Issue:1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Bupivacaine; Catheterization; Cohort Studies; Equipment

1995
Complications of intrathecal opioids and bupivacaine in the treatment of "refractory" cancer pain.
    The Clinical journal of pain, 1995, Volume: 11, Issue:1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Bupivacaine; Catheterization; Cohort Studies; Equipment

1995
Postoperative pulmonary complications. Epidural analgesia using bupivacaine and opioids versus parenteral opioids.
    Anesthesiology, 1993, Volume: 78, Issue:4

    Topics: Abdomen; Adult; Aged; Analgesia, Epidural; Anesthesia, Epidural; Anesthesia, General; Bupivacaine; D

1993
Postoperative pulmonary complications. Epidural analgesia using bupivacaine and opioids versus parenteral opioids.
    Anesthesiology, 1993, Volume: 78, Issue:4

    Topics: Abdomen; Adult; Aged; Analgesia, Epidural; Anesthesia, Epidural; Anesthesia, General; Bupivacaine; D

1993
Prolongation of epidural bupivacaine analgesia with glycerin.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1993, Volume: 40, Issue:5 Pt 1

    Topics: Aged; Analgesia, Epidural; Bupivacaine; Chronic Disease; Delayed-Action Preparations; Female; Glycer

1993
Prolongation of epidural bupivacaine analgesia with glycerin.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1993, Volume: 40, Issue:5 Pt 1

    Topics: Aged; Analgesia, Epidural; Bupivacaine; Chronic Disease; Delayed-Action Preparations; Female; Glycer

1993
Intrathecal coadministration of bupivacaine diminishes morphine dose progression during long-term intrathecal infusion in cancer patients.
    The Clinical journal of pain, 1999, Volume: 15, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Anesthetics, Local; Bupivacaine; Dose-Response R

1999
Intrathecal coadministration of bupivacaine diminishes morphine dose progression during long-term intrathecal infusion in cancer patients.
    The Clinical journal of pain, 1999, Volume: 15, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Anesthetics, Local; Bupivacaine; Dose-Response R

1999

Other Studies

40 other studies available for bupivacaine and Neoplasms

ArticleYear
First Evaluation Switching From Ropivacaine to Highly Concentrated Bupivacaine in Intrathecal Mixtures for Cancer Pain.
    Neuromodulation : journal of the International Neuromodulation Society, 2021, Volume: 24, Issue:7

    Topics: Amides; Anesthetics, Local; Bupivacaine; Cancer Pain; Double-Blind Method; Humans; Neoplasms; Retros

2021
First Evaluation Switching From Ropivacaine to Highly Concentrated Bupivacaine in Intrathecal Mixtures for Cancer Pain.
    Neuromodulation : journal of the International Neuromodulation Society, 2021, Volume: 24, Issue:7

    Topics: Amides; Anesthetics, Local; Bupivacaine; Cancer Pain; Double-Blind Method; Humans; Neoplasms; Retros

2021
Factors Associated with Inadequate Pain Control among Postoperative Patients with Cancer.
    Pain management nursing : official journal of the American Society of Pain Management Nurses, 2018, Volume: 19, Issue:2

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Analgesia, Epidural; Bupivacaine; Cross-Sectional Studie

2018
Factors Associated with Inadequate Pain Control among Postoperative Patients with Cancer.
    Pain management nursing : official journal of the American Society of Pain Management Nurses, 2018, Volume: 19, Issue:2

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Analgesia, Epidural; Bupivacaine; Cross-Sectional Studie

2018
Audit of intrathecal drug delivery for patients with difficult-to-control cancer pain shows a sustained reduction in pain severity scores over a 6-month period.
    Palliative medicine, 2015, Volume: 29, Issue:6

    Topics: Adult; Aged; Analgesics, Opioid; Bupivacaine; Female; Humans; Infusion Pumps, Implantable; Injection

2015
Audit of intrathecal drug delivery for patients with difficult-to-control cancer pain shows a sustained reduction in pain severity scores over a 6-month period.
    Palliative medicine, 2015, Volume: 29, Issue:6

    Topics: Adult; Aged; Analgesics, Opioid; Bupivacaine; Female; Humans; Infusion Pumps, Implantable; Injection

2015
A case of cancer pain management by long-term intrathecal PCA.
    Journal of Nippon Medical School = Nippon Ika Daigaku zasshi, 2010, Volume: 77, Issue:6

    Topics: Adult; Analgesia, Patient-Controlled; Bupivacaine; Female; Humans; Injections, Spinal; Ketamine; Mor

2010
A case of cancer pain management by long-term intrathecal PCA.
    Journal of Nippon Medical School = Nippon Ika Daigaku zasshi, 2010, Volume: 77, Issue:6

    Topics: Adult; Analgesia, Patient-Controlled; Bupivacaine; Female; Humans; Injections, Spinal; Ketamine; Mor

2010
Efficacy of epidural analgesia in patients with cancer pain: a retrospective observational study.
    Yonsei medical journal, 2012, Volume: 53, Issue:3

    Topics: Adult; Analgesia, Epidural; Bupivacaine; Female; Humans; Male; Middle Aged; Morphine; Neoplasms; Pai

2012
Efficacy of epidural analgesia in patients with cancer pain: a retrospective observational study.
    Yonsei medical journal, 2012, Volume: 53, Issue:3

    Topics: Adult; Analgesia, Epidural; Bupivacaine; Female; Humans; Male; Middle Aged; Morphine; Neoplasms; Pai

2012
Opioid "holiday" following antagonist supported detoxification during general anesthesia improves opioid agonist response in a cancer patient with opioid addiction.
    Anesthesiology, 2003, Volume: 98, Issue:2

    Topics: Analgesia, Epidural; Analgesics, Opioid; Anesthesia, General; Anesthetics, Local; Bone Neoplasms; Bu

2003
Opioid "holiday" following antagonist supported detoxification during general anesthesia improves opioid agonist response in a cancer patient with opioid addiction.
    Anesthesiology, 2003, Volume: 98, Issue:2

    Topics: Analgesia, Epidural; Analgesics, Opioid; Anesthesia, General; Anesthetics, Local; Bone Neoplasms; Bu

2003
Local anesthetic switching for intrathecal tachyphylaxis in cancer patients with pain.
    Anesthesia and analgesia, 2003, Volume: 97, Issue:1

    Topics: Adult; Anesthetics, Local; Bupivacaine; Carcinoma, Small Cell; Endometrial Neoplasms; Female; Humans

2003
Local anesthetic switching for intrathecal tachyphylaxis in cancer patients with pain.
    Anesthesia and analgesia, 2003, Volume: 97, Issue:1

    Topics: Adult; Anesthetics, Local; Bupivacaine; Carcinoma, Small Cell; Endometrial Neoplasms; Female; Humans

2003
Local anesthetic switching for intrathecal tachyphylaxis in cancer patients with pain.
    Anesthesia and analgesia, 2004, Volume: 98, Issue:2

    Topics: Analgesics, Opioid; Anesthetics, Dissociative; Anesthetics, Local; Bupivacaine; Humans; Injections,

2004
Local anesthetic switching for intrathecal tachyphylaxis in cancer patients with pain.
    Anesthesia and analgesia, 2004, Volume: 98, Issue:2

    Topics: Analgesics, Opioid; Anesthetics, Dissociative; Anesthetics, Local; Bupivacaine; Humans; Injections,

2004
Efficacy of intrathecal bupivacaine: how important is the flow rate?
    Pain medicine (Malden, Mass.), 2004, Volume: 5, Issue:3

    Topics: Aged; Anesthetics, Local; Bupivacaine; Dose-Response Relationship, Drug; Female; Humans; Infusion Pu

2004
Efficacy of intrathecal bupivacaine: how important is the flow rate?
    Pain medicine (Malden, Mass.), 2004, Volume: 5, Issue:3

    Topics: Aged; Anesthetics, Local; Bupivacaine; Dose-Response Relationship, Drug; Female; Humans; Infusion Pu

2004
Evolving spinal analgesia practice in palliative care.
    Palliative medicine, 2004, Volume: 18, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Analgesia; Analgesia, Epidural; Analgesics, Opioid; Anesthetics, Loc

2004
Evolving spinal analgesia practice in palliative care.
    Palliative medicine, 2004, Volume: 18, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Analgesia; Analgesia, Epidural; Analgesics, Opioid; Anesthetics, Loc

2004
Alternative treatments of breakthrough pain in patients receiving spinal analgesics for cancer pain.
    Journal of pain and symptom management, 2005, Volume: 30, Issue:5

    Topics: Administration, Sublingual; Adult; Aged; Analgesics; Anesthetics, Local; Bupivacaine; Female; Humans

2005
Alternative treatments of breakthrough pain in patients receiving spinal analgesics for cancer pain.
    Journal of pain and symptom management, 2005, Volume: 30, Issue:5

    Topics: Administration, Sublingual; Adult; Aged; Analgesics; Anesthetics, Local; Bupivacaine; Female; Humans

2005
[Possibilities and limitations of morphine analgesia in 377 cases].
    Minerva anestesiologica, 1983, Volume: 49, Issue:9

    Topics: Anesthesia, Epidural; Anesthesia, Spinal; Back Pain; Bupivacaine; Dexamethasone; Humans; Injections,

1983
[Possibilities and limitations of morphine analgesia in 377 cases].
    Minerva anestesiologica, 1983, Volume: 49, Issue:9

    Topics: Anesthesia, Epidural; Anesthesia, Spinal; Back Pain; Bupivacaine; Dexamethasone; Humans; Injections,

1983
Intrathecal morphine and bupivacaine in advanced cancer pain patients implanted at home.
    Journal of pain and symptom management, 1994, Volume: 9, Issue:3

    Topics: Aged; Bupivacaine; Catheterization; Home Care Services; Humans; Injections, Spinal; Male; Middle Age

1994
Intrathecal morphine and bupivacaine in advanced cancer pain patients implanted at home.
    Journal of pain and symptom management, 1994, Volume: 9, Issue:3

    Topics: Aged; Bupivacaine; Catheterization; Home Care Services; Humans; Injections, Spinal; Male; Middle Age

1994
Postoperative epidural bupivacaine-morphine therapy. Experience with 4,227 surgical cancer patients.
    Anesthesiology, 1994, Volume: 81, Issue:2

    Topics: Adult; Aged; Analgesia, Epidural; Bupivacaine; Catheters, Indwelling; Drug Combinations; Female; Hum

1994
Postoperative epidural bupivacaine-morphine therapy. Experience with 4,227 surgical cancer patients.
    Anesthesiology, 1994, Volume: 81, Issue:2

    Topics: Adult; Aged; Analgesia, Epidural; Bupivacaine; Catheters, Indwelling; Drug Combinations; Female; Hum

1994
Long-term intrathecal infusion of morphine and morphine/bupivacaine mixtures in the treatment of cancer pain: a retrospective analysis of 51 cases.
    Pain, 1993, Volume: 55, Issue:1

    Topics: Adult; Aged; Bupivacaine; Catheterization; Drug Combinations; Female; Humans; Injections, Spinal; Ma

1993
Long-term intrathecal infusion of morphine and morphine/bupivacaine mixtures in the treatment of cancer pain: a retrospective analysis of 51 cases.
    Pain, 1993, Volume: 55, Issue:1

    Topics: Adult; Aged; Bupivacaine; Catheterization; Drug Combinations; Female; Humans; Injections, Spinal; Ma

1993
Long-term intrathecal morphine and bupivacaine in patients with refractory cancer pain. Results from a morphine:bupivacaine dose regimen of 0.5:4.75 mg/ml.
    Anesthesiology, 1994, Volume: 80, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Bupivacaine; Female; Humans; Injections, Spinal; Male; Middle Aged;

1994
Long-term intrathecal morphine and bupivacaine in patients with refractory cancer pain. Results from a morphine:bupivacaine dose regimen of 0.5:4.75 mg/ml.
    Anesthesiology, 1994, Volume: 80, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Bupivacaine; Female; Humans; Injections, Spinal; Male; Middle Aged;

1994
Epidural bupivacaine/sufentanil therapy for postoperative pain control in patients tolerant to opioid and unresponsive to epidural bupivacaine/morphine.
    Anesthesiology, 1994, Volume: 80, Issue:2

    Topics: Abdomen; Adult; Analgesia, Epidural; Bupivacaine; Chronic Disease; Drug Tolerance; Female; Humans; M

1994
Epidural bupivacaine/sufentanil therapy for postoperative pain control in patients tolerant to opioid and unresponsive to epidural bupivacaine/morphine.
    Anesthesiology, 1994, Volume: 80, Issue:2

    Topics: Abdomen; Adult; Analgesia, Epidural; Bupivacaine; Chronic Disease; Drug Tolerance; Female; Humans; M

1994
CSF neuropeptides in cancer pain: effects of spinal opioid therapy.
    Acta anaesthesiologica Scandinavica, 1993, Volume: 37, Issue:5

    Topics: Aged; Bupivacaine; Female; Humans; Injections, Epidural; Injections, Spinal; Male; Methadone; Middle

1993
CSF neuropeptides in cancer pain: effects of spinal opioid therapy.
    Acta anaesthesiologica Scandinavica, 1993, Volume: 37, Issue:5

    Topics: Aged; Bupivacaine; Female; Humans; Injections, Epidural; Injections, Spinal; Male; Methadone; Middle

1993
A comparison of postoperative epidural analgesia between patients with chronic cancer taking high doses of oral opioids versus opioid-naive patients.
    Anesthesia and analgesia, 1993, Volume: 76, Issue:2

    Topics: Administration, Oral; Adult; Aged; Analgesia, Epidural; Bupivacaine; Chronic Disease; Female; Humans

1993
A comparison of postoperative epidural analgesia between patients with chronic cancer taking high doses of oral opioids versus opioid-naive patients.
    Anesthesia and analgesia, 1993, Volume: 76, Issue:2

    Topics: Administration, Oral; Adult; Aged; Analgesia, Epidural; Bupivacaine; Chronic Disease; Female; Humans

1993
[Treatment of severe cancer pain via spinal catheters].
    Ugeskrift for laeger, 1996, Nov-11, Volume: 158, Issue:46

    Topics: Adult; Aged; Analgesics, Opioid; Anesthetics, Local; Bupivacaine; Female; Humans; Infusion Pumps, Im

1996
[Treatment of severe cancer pain via spinal catheters].
    Ugeskrift for laeger, 1996, Nov-11, Volume: 158, Issue:46

    Topics: Adult; Aged; Analgesics, Opioid; Anesthetics, Local; Bupivacaine; Female; Humans; Infusion Pumps, Im

1996
Neurological impairment during long-term intrathecal infusion of bupivacaine in cancer patients: a sign of spinal cord compression.
    Pain, 1997, Volume: 69, Issue:1-2

    Topics: Aged; Analgesics, Opioid; Anesthetics, Local; Bupivacaine; Drug Combinations; Female; Humans; Inject

1997
Neurological impairment during long-term intrathecal infusion of bupivacaine in cancer patients: a sign of spinal cord compression.
    Pain, 1997, Volume: 69, Issue:1-2

    Topics: Aged; Analgesics, Opioid; Anesthetics, Local; Bupivacaine; Drug Combinations; Female; Humans; Inject

1997
Neurohistopathological findings after continuous intrathecal administration of morphine or a morphine/bupivacaine mixture in cancer pain patients.
    Acta anaesthesiologica Scandinavica, 1997, Volume: 41, Issue:8

    Topics: Adult; Aged; Analgesics, Opioid; Anesthetics, Local; Bupivacaine; Dura Mater; Female; Humans; Infusi

1997
Neurohistopathological findings after continuous intrathecal administration of morphine or a morphine/bupivacaine mixture in cancer pain patients.
    Acta anaesthesiologica Scandinavica, 1997, Volume: 41, Issue:8

    Topics: Adult; Aged; Analgesics, Opioid; Anesthetics, Local; Bupivacaine; Dura Mater; Female; Humans; Infusi

1997
Neurolytic thoracic paravertebral block in cancer pain. A clinical report.
    Acta anaesthesiologica Scandinavica, 1998, Volume: 42, Issue:5

    Topics: Acute Disease; Adult; Aged; Analgesics; Anesthetics, Local; Bupivacaine; Chronic Disease; Female; Fo

1998
Neurolytic thoracic paravertebral block in cancer pain. A clinical report.
    Acta anaesthesiologica Scandinavica, 1998, Volume: 42, Issue:5

    Topics: Acute Disease; Adult; Aged; Analgesics; Anesthetics, Local; Bupivacaine; Chronic Disease; Female; Fo

1998
The use of interpleural analgesia using bupivacaine for pain relief in advanced cancer.
    Palliative medicine, 1999, Volume: 13, Issue:2

    Topics: Adult; Aged; Analgesia; Anesthetics, Local; Bupivacaine; Catheterization; Female; Home Nursing; Huma

1999
The use of interpleural analgesia using bupivacaine for pain relief in advanced cancer.
    Palliative medicine, 1999, Volume: 13, Issue:2

    Topics: Adult; Aged; Analgesia; Anesthetics, Local; Bupivacaine; Catheterization; Female; Home Nursing; Huma

1999
Chronic epidural bupivacaine-opioid infusion in intractable cancer pain.
    Pain, 1992, Volume: 49, Issue:3

    Topics: Analgesia, Epidural; Blood Pressure; Bupivacaine; Drug Therapy, Combination; Humans; Narcotics; Neop

1992
Chronic epidural bupivacaine-opioid infusion in intractable cancer pain.
    Pain, 1992, Volume: 49, Issue:3

    Topics: Analgesia, Epidural; Blood Pressure; Bupivacaine; Drug Therapy, Combination; Humans; Narcotics; Neop

1992
[Intrathecal morphine therapy in children with cancer].
    Cahiers d'anesthesiologie, 1992, Volume: 40, Issue:7

    Topics: Bupivacaine; Child; Child, Preschool; Female; Fentanyl; Humans; Infant; Injections, Spinal; Male; Mo

1992
[Intrathecal morphine therapy in children with cancer].
    Cahiers d'anesthesiologie, 1992, Volume: 40, Issue:7

    Topics: Bupivacaine; Child; Child, Preschool; Female; Fentanyl; Humans; Infant; Injections, Spinal; Male; Mo

1992
Comments on PAIN, 49 (1992) 293-300.
    Pain, 1992, Volume: 51, Issue:2

    Topics: Analgesia, Epidural; Bupivacaine; Humans; Neoplasms; Pain

1992
Comments on PAIN, 49 (1992) 293-300.
    Pain, 1992, Volume: 51, Issue:2

    Topics: Analgesia, Epidural; Bupivacaine; Humans; Neoplasms; Pain

1992
Management of patients receiving combined epidural morphine and bupivacaine for the treatment of cancer pain.
    Journal of pain and symptom management, 1992, Volume: 7, Issue:2

    Topics: Adult; Analgesia, Epidural; Bupivacaine; Drug Therapy, Combination; Female; Humans; Morphine; Neopla

1992
Management of patients receiving combined epidural morphine and bupivacaine for the treatment of cancer pain.
    Journal of pain and symptom management, 1992, Volume: 7, Issue:2

    Topics: Adult; Analgesia, Epidural; Bupivacaine; Drug Therapy, Combination; Female; Humans; Morphine; Neopla

1992
[Epidural administration of bupivacaine in glycerine solution can prolong analgesia].
    Ma zui xue za zhi = Anaesthesiologica Sinica, 1992, Volume: 30, Issue:1

    Topics: Adult; Analgesia, Epidural; Bupivacaine; Female; Glycerol; Humans; Injections, Epidural; Male; Middl

1992
[Epidural administration of bupivacaine in glycerine solution can prolong analgesia].
    Ma zui xue za zhi = Anaesthesiologica Sinica, 1992, Volume: 30, Issue:1

    Topics: Adult; Analgesia, Epidural; Bupivacaine; Female; Glycerol; Humans; Injections, Epidural; Male; Middl

1992
Neuropathologic findings after long-term intrathecal infusion of morphine and bupivacaine for pain treatment in cancer patients.
    Anesthesiology, 1992, Volume: 76, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Bupivacaine; Female; Humans; Injections, Spinal; Male; Meninges; Mid

1992
Neuropathologic findings after long-term intrathecal infusion of morphine and bupivacaine for pain treatment in cancer patients.
    Anesthesiology, 1992, Volume: 76, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Bupivacaine; Female; Humans; Injections, Spinal; Male; Meninges; Mid

1992
Epidural opiates and local anesthetics for the management of cancer pain.
    Pain, 1991, Volume: 46, Issue:3

    Topics: Adult; Aged; Analgesia, Epidural; Bupivacaine; Drug Therapy, Combination; Female; Humans; Male; Midd

1991
Epidural opiates and local anesthetics for the management of cancer pain.
    Pain, 1991, Volume: 46, Issue:3

    Topics: Adult; Aged; Analgesia, Epidural; Bupivacaine; Drug Therapy, Combination; Female; Humans; Male; Midd

1991
Long-term, open catheterization of the spinal subarachnoid space for continuous infusion of narcotic and bupivacaine in patients with "refractory" cancer pain. A technique of catheterization and its problems and complications.
    The Clinical journal of pain, 1991, Volume: 7, Issue:2

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anesthesia; Anesthesia, Local; Anti-Bacterial Agents; Bu

1991
Long-term, open catheterization of the spinal subarachnoid space for continuous infusion of narcotic and bupivacaine in patients with "refractory" cancer pain. A technique of catheterization and its problems and complications.
    The Clinical journal of pain, 1991, Volume: 7, Issue:2

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anesthesia; Anesthesia, Local; Anti-Bacterial Agents; Bu

1991
Long-term intrathecal morphine and bupivacaine in "refractory" cancer pain. I. Results from the first series of 52 patients.
    Acta anaesthesiologica Scandinavica, 1991, Volume: 35, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Bupivacaine; Female; Humans; Injections, Spinal; Male; Middle Aged;

1991
Long-term intrathecal morphine and bupivacaine in "refractory" cancer pain. I. Results from the first series of 52 patients.
    Acta anaesthesiologica Scandinavica, 1991, Volume: 35, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Bupivacaine; Female; Humans; Injections, Spinal; Male; Middle Aged;

1991
Epidural versus intrathecal morphine-bupivacaine: assessment of consecutive treatments in advanced cancer pain.
    Journal of pain and symptom management, 1990, Volume: 5, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Analgesia, Epidural; Bupivacaine; Dose-Response Relationship, Drug;

1990
Epidural versus intrathecal morphine-bupivacaine: assessment of consecutive treatments in advanced cancer pain.
    Journal of pain and symptom management, 1990, Volume: 5, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Analgesia, Epidural; Bupivacaine; Dose-Response Relationship, Drug;

1990
Spinal bupivacaine for the pain of cancer.
    The Medical journal of Australia, 1989, Mar-20, Volume: 150, Issue:6

    Topics: Adult; Aged; Anesthesia, Spinal; Bupivacaine; Humans; Middle Aged; Neoplasms; Pain, Intractable; Pal

1989
Spinal bupivacaine for the pain of cancer.
    The Medical journal of Australia, 1989, Mar-20, Volume: 150, Issue:6

    Topics: Adult; Aged; Anesthesia, Spinal; Bupivacaine; Humans; Middle Aged; Neoplasms; Pain, Intractable; Pal

1989
Lumbar epidurography and epidural analgesia in cancer patients.
    Pain, 1989, Volume: 36, Issue:3

    Topics: Adult; Analgesia, Epidural; Bupivacaine; Epidural Space; Female; Humans; Iohexol; Lumbosacral Region

1989
Lumbar epidurography and epidural analgesia in cancer patients.
    Pain, 1989, Volume: 36, Issue:3

    Topics: Adult; Analgesia, Epidural; Bupivacaine; Epidural Space; Female; Humans; Iohexol; Lumbosacral Region

1989
Spinal relief of cancer pain.
    The American journal of nursing, 1986, Volume: 86, Issue:9

    Topics: Anesthesia, Epidural; Anesthesia, Spinal; Bupivacaine; Catheterization; Drug Tolerance; Humans; Inje

1986
Spinal relief of cancer pain.
    The American journal of nursing, 1986, Volume: 86, Issue:9

    Topics: Anesthesia, Epidural; Anesthesia, Spinal; Bupivacaine; Catheterization; Drug Tolerance; Humans; Inje

1986
[Hygienic relations and stability of drugs in peridural long-term infusion with implanted or external pumps].
    Der Anaesthesist, 1985, Volume: 34, Issue:5

    Topics: Abscess; Anesthesia, Epidural; Bacterial Infections; Bacteriological Techniques; Bupivacaine; Drug C

1985
[Hygienic relations and stability of drugs in peridural long-term infusion with implanted or external pumps].
    Der Anaesthesist, 1985, Volume: 34, Issue:5

    Topics: Abscess; Anesthesia, Epidural; Bacterial Infections; Bacteriological Techniques; Bupivacaine; Drug C

1985
Treatment of intractable pain by bupivacaine nerve-block.
    Lancet (London, England), 1971, Dec-25, Volume: 2, Issue:7739

    Topics: Aged; Analgesia; Anesthesia, Conduction; Anesthetics, Local; Bupivacaine; Female; Humans; Male; Midd

1971
Treatment of intractable pain by bupivacaine nerve-block.
    Lancet (London, England), 1971, Dec-25, Volume: 2, Issue:7739

    Topics: Aged; Analgesia; Anesthesia, Conduction; Anesthetics, Local; Bupivacaine; Female; Humans; Male; Midd

1971
Relieving pain in the terminally ill.
    Geriatrics, 1973, Volume: 28, Issue:7

    Topics: Administration, Oral; Alcohols; Anesthesia, Spinal; Antidepressive Agents; Autonomic Nerve Block; Bu

1973
Relieving pain in the terminally ill.
    Geriatrics, 1973, Volume: 28, Issue:7

    Topics: Administration, Oral; Alcohols; Anesthesia, Spinal; Antidepressive Agents; Autonomic Nerve Block; Bu

1973