bupivacaine has been researched along with Myocardial Ischemia in 21 studies
Bupivacaine: A widely used local anesthetic agent.
1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide : A piperidinecarboxamide obtained by formal condensation of the carboxy group of N-butylpipecolic acid with the amino group of 2,6-dimethylaniline.
bupivacaine : A racemate composed of equimolar amounts of dextrobupivacaine and levobupivacaine. Used (in the form of its hydrochloride hydrate) as a local anaesthetic.
Myocardial Ischemia: A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).
| Excerpt | Relevance | Reference |
|---|---|---|
| " The study's objectives were threefold: (i) evaluate the myocardial toxicity of levobupivacaine when administered intravenously; (ii) investigate levobupivacaine toxicity on cardiomyocytes mitochondrial functions and cellular structure; (iii) assess the protective effects of a lipid emulsion in the presence or absence of myocardial ischemia." | 7.81 | Electrophysiological, haemodynamic, and mitochondrial alterations induced by levobupivacaine during myocardial ischemia in a pig model: protection by lipid emulsions? ( Bui-Xuan, B; Chevalier, P; Descotes, J; Mamou, Z; Romestaing, C; Timour, Q, 2015) |
| "Myocardial ischemia sensitizes the cardiotoxic effects of bupivacaine, especially the propensity to ventricular fibrillation." | 7.69 | Bupivacaine hastens the ischemia-induced decrease of the electrical ventricular fibrillation threshold. ( Aupetit, JF; Bertrix, L; Faucon, G; Freysz, M; Loufoua, J; Timour, Q, 1995) |
| "The incidence of spontaneous arrhythmias was reduced by 5 and 10 microM bupivacaine during ischemia and reperfusion and was enhanced by 1 microM bupivacaine during the ischemic phase." | 5.30 | Proarrhythmic and antiarrhythmic effects of bupivacaine in an in vitro model of myocardial ischemia and reperfusion. ( Babatasi, G; Bricard, H; Ducouret, P; Flais, F; Gérard, JL; Khayat, A; Picard, S; Potier, JC; Rouet, R, 1998) |
| "We report a patient with chronic renal failure and ischemic heart disease who developed clinically significant methemoglobinemia after an axillary block with bupivacaine and additional injection of lidocaine in the operative field." | 5.30 | Methemoglobinemia after axillary block with bupivacaine and additional injection of lidocaine in the operative field. ( Dieterich, HJ; Mühlbauer, B; Schroeder, TH, 1999) |
| "To determine if epinephrine (EPI) added to a solution of bupivacaine (BUP) injected for use in superficial cervical plexus blockade (SCPB) lowers plasma BUP concentrations after injection and whether this addition of EPI resulted in tachycardia, cardiac arrhythmias, or both." | 5.09 | Plasma bupivacaine concentrations and effects of epinephrine after superficial cervical plexus blockade in patients undergoing carotid endarterectomy. ( Butterworth, JF; Colonna, DM; Harwood, TN; Samuel, M, 1999) |
| " Forty-three patients with coronary artery disease were allocated to receive either incremental spinal anaesthesia (bupivacaine 0." | 5.08 | Perioperative myocardial ischaemia in patients undergoing surgery for fractured hip randomized to incremental spinal, single-dose spinal or general anaesthesia. ( Brink, O; Carlsson, PS; Dalsgaard, J; Felsby, S; Jakobsen, KB; Juelsgaard, P; Sand, NP; Thygesen, K, 1998) |
| " The study's objectives were threefold: (i) evaluate the myocardial toxicity of levobupivacaine when administered intravenously; (ii) investigate levobupivacaine toxicity on cardiomyocytes mitochondrial functions and cellular structure; (iii) assess the protective effects of a lipid emulsion in the presence or absence of myocardial ischemia." | 3.81 | Electrophysiological, haemodynamic, and mitochondrial alterations induced by levobupivacaine during myocardial ischemia in a pig model: protection by lipid emulsions? ( Bui-Xuan, B; Chevalier, P; Descotes, J; Mamou, Z; Romestaing, C; Timour, Q, 2015) |
| "Myocardial ischemia sensitizes the cardiotoxic effects of bupivacaine, especially the propensity to ventricular fibrillation." | 3.69 | Bupivacaine hastens the ischemia-induced decrease of the electrical ventricular fibrillation threshold. ( Aupetit, JF; Bertrix, L; Faucon, G; Freysz, M; Loufoua, J; Timour, Q, 1995) |
| "The impairment of intraventricular conduction by bupivacaine may result in reentrant arrhythmias including ventricular fibrillation." | 3.68 | Enhancement by ischemia of the risk of cardiac disorders, especially fibrillation, in regional anesthesia with bupivacaine. ( Bertrix, L; Faucon, G; Freysz, M; Loufoua-Moundanga, J; Omar, S; Timour, Q, 1993) |
| "Study endpoints included assessment of postoperative pain at rest and with coughing, rescue analgesic need, and postoperative course." | 2.78 | Effects of epidural anesthesia on acute and chronic pain after coronary artery bypass grafting. ( Kilickan, L; Onan, B; Onan, IS; Sanisoglu, I, 2013) |
| "In patients with ischemic heart disease, high thoracic epidural analgesia (TEA) has been proposed to improve abnormalities of coronary function by inhibiting cardiac sympathetic tone." | 2.71 | Effects of high thoracic epidural analgesia on myocardial blood flow in patients with ischemic heart disease. ( Aldershvile, J; Eliasen, K; Freiberg, J; Holm, S; Kelbaek, H; Kofoed, KF; Nygård, E, 2005) |
| "Postoperative myocardial ischemia is associated with adverse cardiac outcome." | 2.68 | Epidural analgesia and intravenous patient-controlled analgesia result in similar rates of postoperative myocardial ischemia after aortic surgery. ( Bois, S; Boudreault, D; Couture, P; Fugère, F; Girard, D; Lacombe, P; Nadeau, N, 1997) |
| "The incidence of spontaneous arrhythmias was reduced by 5 and 10 microM bupivacaine during ischemia and reperfusion and was enhanced by 1 microM bupivacaine during the ischemic phase." | 1.30 | Proarrhythmic and antiarrhythmic effects of bupivacaine in an in vitro model of myocardial ischemia and reperfusion. ( Babatasi, G; Bricard, H; Ducouret, P; Flais, F; Gérard, JL; Khayat, A; Picard, S; Potier, JC; Rouet, R, 1998) |
| "We report a patient with chronic renal failure and ischemic heart disease who developed clinically significant methemoglobinemia after an axillary block with bupivacaine and additional injection of lidocaine in the operative field." | 1.30 | Methemoglobinemia after axillary block with bupivacaine and additional injection of lidocaine in the operative field. ( Dieterich, HJ; Mühlbauer, B; Schroeder, TH, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 13 (61.90) | 18.2507 |
| 2000's | 3 (14.29) | 29.6817 |
| 2010's | 5 (23.81) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gonon, A | 1 |
| Richter, A | 1 |
| Cederholm, I | 1 |
| Khan, J | 1 |
| Novak, J | 1 |
| Milovanovic, M | 1 |
| Janerot-Sjoberg, B | 1 |
| Onan, B | 1 |
| Onan, IS | 1 |
| Kilickan, L | 1 |
| Sanisoglu, I | 1 |
| Mamou, Z | 1 |
| Descotes, J | 1 |
| Chevalier, P | 1 |
| Bui-Xuan, B | 1 |
| Romestaing, C | 1 |
| Timour, Q | 3 |
| Garneau, SY | 1 |
| Deschamps, A | 1 |
| Couture, P | 2 |
| Levesque, S | 1 |
| Babin, D | 1 |
| Lambert, J | 1 |
| Tardif, JC | 1 |
| Perrault, LP | 1 |
| Denault, AY | 1 |
| Tsuchiya, H | 1 |
| Mizogami, M | 1 |
| Shigemi, K | 1 |
| Nygård, E | 1 |
| Kofoed, KF | 1 |
| Freiberg, J | 1 |
| Holm, S | 1 |
| Aldershvile, J | 1 |
| Eliasen, K | 1 |
| Kelbaek, H | 1 |
| Shupak, RC | 1 |
| Mizuyama, K | 1 |
| Sato, S | 1 |
| Okubo, N | 1 |
| Naito, H | 1 |
| Gannedahl, P | 1 |
| Edner, M | 1 |
| Lindahl, SG | 1 |
| Ljungqvist, O | 1 |
| Freysz, M | 2 |
| Bertrix, L | 2 |
| Loufoua, J | 1 |
| Aupetit, JF | 1 |
| Faucon, G | 2 |
| Mergner, GW | 1 |
| Stolte, AL | 1 |
| Frame, WB | 1 |
| Lim, HJ | 1 |
| Loufoua-Moundanga, J | 1 |
| Omar, S | 1 |
| Alessandri, C | 1 |
| Bergeron, P | 1 |
| Olausson, K | 1 |
| Magnusdottir, H | 1 |
| Lurje, L | 1 |
| Wennerblom, B | 1 |
| Emanuelsson, H | 1 |
| Ricksten, SE | 1 |
| Bois, S | 1 |
| Boudreault, D | 1 |
| Lacombe, P | 1 |
| Fugère, F | 1 |
| Girard, D | 1 |
| Nadeau, N | 1 |
| Picard, S | 1 |
| Rouet, R | 1 |
| Flais, F | 1 |
| Ducouret, P | 1 |
| Babatasi, G | 1 |
| Khayat, A | 1 |
| Potier, JC | 1 |
| Bricard, H | 1 |
| Gérard, JL | 1 |
| Juelsgaard, P | 1 |
| Sand, NP | 1 |
| Felsby, S | 1 |
| Dalsgaard, J | 1 |
| Jakobsen, KB | 1 |
| Brink, O | 1 |
| Carlsson, PS | 1 |
| Thygesen, K | 1 |
| Schroeder, TH | 1 |
| Dieterich, HJ | 1 |
| Mühlbauer, B | 1 |
| Sbarigia, E | 1 |
| DarioVizza, C | 1 |
| Antonini, M | 1 |
| Speziale, F | 1 |
| Maritti, M | 1 |
| Fiorani, B | 1 |
| Fedele, F | 1 |
| Fiorani, P | 1 |
| Harwood, TN | 1 |
| Butterworth, JF | 1 |
| Colonna, DM | 1 |
| Samuel, M | 1 |
| Scheinin, H | 1 |
| Virtanen, T | 1 |
| Kentala, E | 1 |
| Uotila, P | 1 |
| Laitio, T | 1 |
| Hartiala, J | 1 |
| Heikkilä, H | 1 |
| Sariola-Heinonen, K | 1 |
| Pullisaar, O | 1 |
| Yli-Mäyry, S | 1 |
| Jalonen, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Study for the Evaluation of the Effectiveness of Stellate Ganglion Blockade in Preventing Postoperative Atrial Fibrillation[NCT03269383] | Phase 4 | 0 participants (Actual) | Interventional | 2019-12-31 | Withdrawn (stopped due to Lack of funding and other logistical issues) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
9 trials available for bupivacaine and Myocardial Ischemia
| Article | Year |
|---|---|
Effects of thoracic epidural analgesia on exercise-induced myocardial ischaemia in refractory angina pectoris.
Topics: Aged; Aged, 80 and over; Analgesia, Epidural; Anesthetics, Local; Angina Pectoris; Bupivacaine; Doub | 2019 |
Effects of epidural anesthesia on acute and chronic pain after coronary artery bypass grafting.
Topics: Aged; Anesthesia, Epidural; Anesthesia, General; Bupivacaine; Coronary Artery Bypass; Female; Humans | 2013 |
Effects of high thoracic epidural analgesia on myocardial blood flow in patients with ischemic heart disease.
Topics: Aged; Analgesia, Epidural; Blood Flow Velocity; Bupivacaine; Coronary Circulation; Heart; Humans; Ma | 2005 |
Anti-ischemic and anti-anginal effects of thoracic epidural anesthesia versus those of conventional medical therapy in the treatment of severe refractory unstable angina pectoris.
Topics: Aged; Anesthesia, Epidural; Angina, Unstable; Antihypertensive Agents; Bupivacaine; Electrocardiogra | 1997 |
Epidural analgesia and intravenous patient-controlled analgesia result in similar rates of postoperative myocardial ischemia after aortic surgery.
Topics: Aged; Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthetics, Local; Ao | 1997 |
Perioperative myocardial ischaemia in patients undergoing surgery for fractured hip randomized to incremental spinal, single-dose spinal or general anaesthesia.
Topics: Aged; Aged, 80 and over; Anesthesia, General; Anesthesia, Spinal; Anesthetics, Local; Bupivacaine; C | 1998 |
Locoregional versus general anesthesia in carotid surgery: is there an impact on perioperative myocardial ischemia? Results of a prospective monocentric randomized trial.
Topics: Aged; Alfentanil; Anesthesia, General; Anesthesia, Local; Anesthetics, Intravenous; Anesthetics, Loc | 1999 |
Plasma bupivacaine concentrations and effects of epinephrine after superficial cervical plexus blockade in patients undergoing carotid endarterectomy.
Topics: Aged; Aged, 80 and over; Anesthetics, Local; Arrhythmias, Cardiac; Arteries; Bupivacaine; Cervical P | 1999 |
Epidural infusion of bupivacaine and fentanyl reduces perioperative myocardial ischaemia in elderly patients with hip fracture--a randomized controlled trial.
Topics: Aged; Aged, 80 and over; Anesthesia, Epidural; Anesthetics, Intravenous; Anesthetics, Local; Area Un | 2000 |
12 other studies available for bupivacaine and Myocardial Ischemia
| Article | Year |
|---|---|
Electrophysiological, haemodynamic, and mitochondrial alterations induced by levobupivacaine during myocardial ischemia in a pig model: protection by lipid emulsions?
Topics: Action Potentials; Anesthetics, Local; Animals; Arterial Pressure; Bradycardia; Bupivacaine; Calcium | 2015 |
Preliminary experience in the use of preoperative echo-guided left stellate ganglion block in patients undergoing cardiac surgery.
Topics: Aged; Anesthesia, General; Anesthetics, Local; Arrhythmias, Cardiac; Autonomic Nerve Block; Blood Pr | 2011 |
Increasing membrane interactions of local anaesthetics as hypothetic mechanism for their cardiotoxicity enhanced by myocardial ischaemia.
Topics: 1,2-Dipalmitoylphosphatidylcholine; Anesthetics, Local; Animals; Bupivacaine; Cardiolipins; Chemical | 2012 |
Lipid emulsion for bupivacaine toxicity: too soon to celebrate?
Topics: Anesthetics, Local; Bupivacaine; Fat Emulsions, Intravenous; Heart Arrest; Humans; Male; Middle Aged | 2007 |
Spinal anesthesia attenuates myocardial ischemia during coronary artery spasm induced by intraaortic methacholine in rats.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthesia, Sp | 1995 |
Minimal influence of anaesthesia and abdominal surgery on computerized vectorcardiography recordings.
Topics: Adult; Aged; Anesthesia, Intravenous; Anesthesia, Spinal; Bupivacaine; Cholecystectomy; Female; Fent | 1995 |
Bupivacaine hastens the ischemia-induced decrease of the electrical ventricular fibrillation threshold.
Topics: Action Potentials; Animals; Blood Pressure; Bupivacaine; Cardiac Pacing, Artificial; Female; Heart; | 1995 |
Combined epidural analgesia and general anesthesia induce ischemia distal to a severe coronary artery stenosis in swine.
Topics: Anesthesia, Epidural; Anesthesia, General; Animals; Blood Pressure; Bupivacaine; Coronary Circulatio | 1994 |
Enhancement by ischemia of the risk of cardiac disorders, especially fibrillation, in regional anesthesia with bupivacaine.
Topics: Action Potentials; Anesthesia, Conduction; Animals; Blood Pressure; Bupivacaine; Electrocardiography | 1993 |
Local anesthesia in carotid angioplasty.
Topics: Age Factors; Aged; Anesthesia, General; Anesthetics, Local; Angina, Unstable; Angioplasty, Balloon; | 1996 |
Proarrhythmic and antiarrhythmic effects of bupivacaine in an in vitro model of myocardial ischemia and reperfusion.
Topics: Action Potentials; Anesthetics, Local; Animals; Arrhythmias, Cardiac; Bupivacaine; Dose-Response Rel | 1998 |
Methemoglobinemia after axillary block with bupivacaine and additional injection of lidocaine in the operative field.
Topics: Acidosis; Alkalies; Anesthetics, Local; Antidotes; Axilla; Bupivacaine; Drug Interactions; Female; H | 1999 |