bupivacaine has been researched along with Methemoglobinemia in 9 studies
Bupivacaine: A widely used local anesthetic agent.
1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide : A piperidinecarboxamide obtained by formal condensation of the carboxy group of N-butylpipecolic acid with the amino group of 2,6-dimethylaniline.
bupivacaine : A racemate composed of equimolar amounts of dextrobupivacaine and levobupivacaine. Used (in the form of its hydrochloride hydrate) as a local anaesthetic.
Methemoglobinemia: The presence of methemoglobin in the blood, resulting in cyanosis. A small amount of methemoglobin is present in the blood normally, but injury or toxic agents convert a larger proportion of hemoglobin into methemoglobin, which does not function reversibly as an oxygen carrier. Methemoglobinemia may be due to a defect in the enzyme NADH methemoglobin reductase (an autosomal recessive trait) or to an abnormality in hemoglobin M (an autosomal dominant trait). (Dorland, 27th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "We report a patient with chronic renal failure and ischemic heart disease who developed clinically significant methemoglobinemia after an axillary block with bupivacaine and additional injection of lidocaine in the operative field." | 5.30 | Methemoglobinemia after axillary block with bupivacaine and additional injection of lidocaine in the operative field. ( Dieterich, HJ; Mühlbauer, B; Schroeder, TH, 1999) |
| "Methemoglobinemia (MetHb) after exposure to benzocaine (BZC) has been reported for more than 50 years, however the pathophysiologic mechanism has not been previously established." | 3.80 | Identification of N-Hydroxy-para-aminobenzoic acid in a cyanotic child after benzocaine exposure. ( Casavant, MJ; Gerona, RR; Ho, RY; Russell, JL; Spiller, HA, 2014) |
| "We report the case of a full-term neonate who presented with cyanosis from birth secondary to methemoglobinemia precipitated by the obstetric use of bupivacaine in a spinal anaesthetic for caesarean delivery." | 3.79 | Thinking outside of the blue box: a case presentation of neonatal methemoglobinemia. ( Aladangady, N; Parish, E; van de Vijver, M, 2013) |
| " Methemoglobinemia was suspected and treated with ascorbine acid and methylene blue." | 3.77 | [Toxic methemoglobinemia]. ( Bender, P; Neuhaus, H, 2011) |
| "Phenazopyridine has been associated with methemoglobinemia in patients who have received an overdose, have decreased renal function, or are discovered to be unusually susceptible to the drug (ie, they may have an undetected NADH methemoglobin reductase deficiency)." | 3.68 | Acquired methemoglobinemia from multiple oxidants. ( Bailey, MK; Baker, JD; Conroy, JM; Dorman, BH; Martin, WJ, 1993) |
| "Prilocaine was chosen as the medium-long acting LA because it has the lowest toxicity of this group and for pharmacological reasons." | 2.66 | [Clinical effectiveness and systemic toxicity of various mixtures of prilocaine and bupivacaine in axillary plexus block]. ( Börner, P; Tryba, M, 1988) |
| "We report a patient with chronic renal failure and ischemic heart disease who developed clinically significant methemoglobinemia after an axillary block with bupivacaine and additional injection of lidocaine in the operative field." | 1.30 | Methemoglobinemia after axillary block with bupivacaine and additional injection of lidocaine in the operative field. ( Dieterich, HJ; Mühlbauer, B; Schroeder, TH, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (22.22) | 18.7374 |
| 1990's | 2 (22.22) | 18.2507 |
| 2000's | 1 (11.11) | 29.6817 |
| 2010's | 4 (44.44) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| van de Vijver, M | 1 |
| Parish, E | 1 |
| Aladangady, N | 1 |
| Spiller, HA | 1 |
| Russell, JL | 1 |
| Casavant, MJ | 1 |
| Ho, RY | 1 |
| Gerona, RR | 1 |
| Berksun, H | 1 |
| Akpek, EA | 1 |
| Arslan, G | 1 |
| Bender, P | 1 |
| Neuhaus, H | 1 |
| Sambrook, PJ | 1 |
| Smith, W | 1 |
| Elijah, J | 1 |
| Goss, AN | 1 |
| Rupieper, N | 1 |
| Stöcker, L | 1 |
| Conroy, JM | 1 |
| Baker, JD | 1 |
| Martin, WJ | 1 |
| Bailey, MK | 1 |
| Dorman, BH | 1 |
| Schroeder, TH | 1 |
| Dieterich, HJ | 1 |
| Mühlbauer, B | 1 |
| Tryba, M | 1 |
| Börner, P | 1 |
2 trials available for bupivacaine and Methemoglobinemia
| Article | Year |
|---|---|
Methemoglobin levels during epidural anesthesia for renal transplantation--comparison of prilocaine with bupivacaine.
Topics: Adult; Anesthesia, Epidural; Anesthetics, Local; Blood Gas Analysis; Bupivacaine; Female; Hemodynami | 2008 |
[Clinical effectiveness and systemic toxicity of various mixtures of prilocaine and bupivacaine in axillary plexus block].
Topics: Adolescent; Adult; Aged; Axilla; Bupivacaine; Clinical Trials as Topic; Dose-Response Relationship, | 1988 |
7 other studies available for bupivacaine and Methemoglobinemia
| Article | Year |
|---|---|
Thinking outside of the blue box: a case presentation of neonatal methemoglobinemia.
Topics: Anesthesia, Spinal; Anesthetics, Local; Bupivacaine; Cesarean Section; Female; Humans; Infant, Newbo | 2013 |
Identification of N-Hydroxy-para-aminobenzoic acid in a cyanotic child after benzocaine exposure.
Topics: 4-Aminobenzoic Acid; Acetaminophen; Administration, Topical; Benzocaine; Bupivacaine; Child; Cyanosi | 2014 |
[Toxic methemoglobinemia].
Topics: Ambulatory Surgical Procedures; Anesthetics, Local; Bupivacaine; Critical Care; Diagnosis, Different | 2011 |
Severe adverse reactions to dental local anaesthetics: systemic reactions.
Topics: Adolescent; Adult; Adverse Drug Reaction Reporting Systems; Aged; Aged, 80 and over; Anesthesia, Den | 2011 |
[Met-Hb formation and local anesthesia using bupivacaine, carticaine and etidocaine (author's transl)].
Topics: Anesthesia, Local; Bupivacaine; Carticaine; Etidocaine; Humans; Methemoglobinemia | 1981 |
Acquired methemoglobinemia from multiple oxidants.
Topics: Administration, Topical; Adult; Analgesia, Epidural; Blood Gas Analysis; Bupivacaine; Cytochrome-B(5 | 1993 |
Methemoglobinemia after axillary block with bupivacaine and additional injection of lidocaine in the operative field.
Topics: Acidosis; Alkalies; Anesthetics, Local; Antidotes; Axilla; Bupivacaine; Drug Interactions; Female; H | 1999 |