bupivacaine has been researched along with Melanoma in 9 studies
Bupivacaine: A widely used local anesthetic agent.
1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide : A piperidinecarboxamide obtained by formal condensation of the carboxy group of N-butylpipecolic acid with the amino group of 2,6-dimethylaniline.
bupivacaine : A racemate composed of equimolar amounts of dextrobupivacaine and levobupivacaine. Used (in the form of its hydrochloride hydrate) as a local anaesthetic.
Melanoma: A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Human colon cancer cells and human melanoma cells were cultured and then treated with 1 mM bupivacaine or levobupivacaine for up to 24 or 48 h." | 7.91 | Both Bupivacaine and Levobupivacaine inhibit colon cancer cell growth but not melanoma cells in vitro. ( Chen, L; Han, C; Hirota, K; Li, T; Ma, D; Masters, J; Wu, L; Zhao, H, 2019) |
| "The effect of hyperthermia and bupivacaine, alone and in combination, on the clonogenic activity of a human melanoma cell line was investigated." | 7.70 | Thermal behavior of human melanoma cell line in vitro and enhancement of hyperthermic response by bupivacaine. ( Antonucci, E; Bruno, T; Di Padova, M; Dolo, V; Floridi, A; Gentile, FP; Pavan, A; Rubiu, O, 1998) |
| "To test whether prophylactic neural blockade of noziceptive afferents or antiemetics diminutes postoperative nausea and vomiting (PONV) we studied in a randomised, prospective, and ouble-blind fashion 102 patients receiving implantation of an episcleral radioactive applicator for treatment of ocular malignant melanoma during remifentanil-propofol-anaesthesia." | 5.10 | [Blocking nociceptive afferents by retrobulbar bupivacaine does not decrease nausea and vomiting after propofol-remifentanil anaesthesia]. ( Apfel, CC; Armbruster, W; Bornfeld, N; Müller, D; Peters, J; Unkel, W, 2003) |
| "Ropivacaine and lidocaine but not bupivacaine inhibited migration and proliferation, and induced apoptosis in melanoma cells." | 3.96 | Cytotoxicity of amide-linked local anesthetics on melanoma cells via inhibition of Ras and RhoA signaling independent of sodium channel blockade. ( Peng, X; Zhang, Y; Zheng, Q, 2020) |
| "Human colon cancer cells and human melanoma cells were cultured and then treated with 1 mM bupivacaine or levobupivacaine for up to 24 or 48 h." | 3.91 | Both Bupivacaine and Levobupivacaine inhibit colon cancer cell growth but not melanoma cells in vitro. ( Chen, L; Han, C; Hirota, K; Li, T; Ma, D; Masters, J; Wu, L; Zhao, H, 2019) |
| "The effect of hyperthermia and bupivacaine, alone and in combination, on the clonogenic activity of a human melanoma cell line was investigated." | 3.70 | Thermal behavior of human melanoma cell line in vitro and enhancement of hyperthermic response by bupivacaine. ( Antonucci, E; Bruno, T; Di Padova, M; Dolo, V; Floridi, A; Gentile, FP; Pavan, A; Rubiu, O, 1998) |
| "Up to 90% of patients with advanced cancer experience intractable pain." | 2.50 | Treatment of medically refractory cancer pain with a combination of intrathecal neuromodulation and neurosurgical ablation: case series and literature review. ( Bentley, JN; Patil, PG; Rosenberg, WS; Viswanathan, A, 2014) |
| "Bupivacaine was more potent than lidocaine both on the glycolytic enzymes and on cell viability." | 1.31 | Detachment of the glycolytic enzymes, phosphofructokinase and aldolase, from cytoskeleton of melanoma cells, induced by local anesthetics. ( Beitner, R; Schwartz, D, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (11.11) | 18.2507 |
| 2000's | 5 (55.56) | 29.6817 |
| 2010's | 2 (22.22) | 24.3611 |
| 2020's | 1 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Zheng, Q | 1 |
| Peng, X | 1 |
| Zhang, Y | 1 |
| Li, T | 1 |
| Chen, L | 1 |
| Zhao, H | 1 |
| Wu, L | 1 |
| Masters, J | 1 |
| Han, C | 1 |
| Hirota, K | 1 |
| Ma, D | 1 |
| Bentley, JN | 1 |
| Viswanathan, A | 1 |
| Rosenberg, WS | 1 |
| Patil, PG | 1 |
| Müller, D | 1 |
| Armbruster, W | 1 |
| Unkel, W | 1 |
| Apfel, CC | 1 |
| Bornfeld, N | 1 |
| Peters, J | 1 |
| Bowyer, J | 1 |
| Jones, A | 1 |
| Damato, B | 1 |
| Leach, A | 1 |
| Shankar, J | 1 |
| Tripathi, A | 1 |
| Holmfred, A | 1 |
| Jastrzebski, T | 1 |
| Sommer, A | 1 |
| Swierblewski, M | 1 |
| Lass, P | 1 |
| Rogowski, J | 1 |
| Drucis, K | 1 |
| Kopacz, A | 1 |
| Bruno, T | 1 |
| Gentile, FP | 1 |
| Di Padova, M | 1 |
| Antonucci, E | 1 |
| Rubiu, O | 1 |
| Dolo, V | 1 |
| Pavan, A | 1 |
| Floridi, A | 1 |
| Schwartz, D | 1 |
| Beitner, R | 1 |
1 review available for bupivacaine and Melanoma
| Article | Year |
|---|---|
Treatment of medically refractory cancer pain with a combination of intrathecal neuromodulation and neurosurgical ablation: case series and literature review.
Topics: Adolescent; Aged; Bone Neoplasms; Bupivacaine; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell | 2014 |
1 trial available for bupivacaine and Melanoma
| Article | Year |
|---|---|
[Blocking nociceptive afferents by retrobulbar bupivacaine does not decrease nausea and vomiting after propofol-remifentanil anaesthesia].
Topics: Aged; Anesthesia, Intravenous; Anesthetics, Intravenous; Anesthetics, Local; Bupivacaine; Double-Bli | 2003 |
7 other studies available for bupivacaine and Melanoma
| Article | Year |
|---|---|
Cytotoxicity of amide-linked local anesthetics on melanoma cells via inhibition of Ras and RhoA signaling independent of sodium channel blockade.
Topics: Anesthetics, Local; Bupivacaine; Cell Death; Cell Line, Tumor; Humans; In Vitro Techniques; Lidocain | 2020 |
Both Bupivacaine and Levobupivacaine inhibit colon cancer cell growth but not melanoma cells in vitro.
Topics: Anesthetics, Local; Apoptosis; Bupivacaine; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; | 2019 |
The subjective experience of early postoperative pain following retrobulbar anaesthesia for enucleation and primary orbital implant.
Topics: Adult; Aged; Aged, 80 and over; Bupivacaine; Female; Humans; Male; Melanoma; Middle Aged; Nerve Bloc | 2003 |
Failed intrathecal analgesia following severe, terminal cancer pain.
Topics: Amines; Analgesics; Anesthetics, Local; Back Pain; Bupivacaine; Catheterization; Clonidine; Cyclohex | 2004 |
Possibilities of improving the parameters of hyperthermia in regional isolated limb perfusion using epidural bupivacaine and accurate temperature measurement of the three layers of limb tissue.
Topics: Adult; Aged; Bupivacaine; Chemotherapy, Cancer, Regional Perfusion; Combined Modality Therapy; Femal | 2006 |
Thermal behavior of human melanoma cell line in vitro and enhancement of hyperthermic response by bupivacaine.
Topics: Bupivacaine; Cell Survival; Hot Temperature; Humans; Hyperthermia, Induced; Melanoma; Thermodynamics | 1998 |
Detachment of the glycolytic enzymes, phosphofructokinase and aldolase, from cytoskeleton of melanoma cells, induced by local anesthetics.
Topics: Anesthetics, Local; Animals; Antineoplastic Agents; Bupivacaine; Cell Death; Cell Survival; Cytoskel | 2000 |