bupivacaine has been researched along with Lung Neoplasms in 30 studies
Bupivacaine: A widely used local anesthetic agent.
1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide : A piperidinecarboxamide obtained by formal condensation of the carboxy group of N-butylpipecolic acid with the amino group of 2,6-dimethylaniline.
bupivacaine : A racemate composed of equimolar amounts of dextrobupivacaine and levobupivacaine. Used (in the form of its hydrochloride hydrate) as a local anaesthetic.
Lung Neoplasms: Tumors or cancer of the LUNG.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Bupivacaine treatment also decreased colony formation, migration, and invasion of HepG2 and SNU-449 cells." | 5.62 | Local anesthetic bupivacaine inhibits proliferation and metastasis of hepatocellular carcinoma cells via suppressing PI3K/Akt and MAPK signaling. ( Cai, X; Guan, H; Guo, W; Wang, L; Yan, N; Zhu, L, 2021) |
| "At POD1, median postoperative pain at rest was 2." | 2.79 | Prospective, comparative study of the On-Q® PainBuster® postoperative pain relief system and thoracic epidural analgesia after thoracic surgery. ( Diez, C; Hofmann, HS; Ittner, KP; Potzger, T; Ried, M; Rupp, A; Schilling, C; Szöke, T, 2014) |
| "The degree of postoperative pain was assessed on the total dose of additional analgesics administered, a visual analog scale (VAS), a verbal pain score at rest (VPS-R) and on movement (VPS-M), from the day of surgery to the 2nd postoperative day (2 POD)." | 2.72 | The efficacy of epidural analgesia after video-assisted thoracoscopic surgery: a randomized control study. ( Iwatani, K; Kobayashi, H; Mori, T; Nomori, H; Terasaki, H; Yoshimoto, K; Yoshioka, M, 2006) |
| "The patients' own estimate of the postoperative pain was not significantly different between the groups, but the epidurally treated patients required fewer doses of supplementary analgesic than those given just a single dose of intercostal bupivacaine." | 2.66 | Sympatho-adrenal and pituitary hormone responses during and immediately after thoracic surgery--modulation by four different pain treatments. ( Asantila, R; Lindberg, R; Scheinin, B; Scheinin, M; Viinamäki, O, 1987) |
| "Up to 90% of patients with advanced cancer experience intractable pain." | 2.50 | Treatment of medically refractory cancer pain with a combination of intrathecal neuromodulation and neurosurgical ablation: case series and literature review. ( Bentley, JN; Patil, PG; Rosenberg, WS; Viswanathan, A, 2014) |
| " After adjusting for important clinical and pathological covariates, a significant dose-response relationship was observed between epidural bupivacaine dose and all-cause mortality (adjusted hazard ratio: 1." | 1.72 | Dose-response relationship between epidural bupivacaine dose and mortality risk after surgical resection of nonsmall-cell lung cancer. ( Cata, JP; Chang, KY; Li, CC; Lin, SP; Tai, YH; Tsou, MY; Wang, CW; Wu, HL, 2022) |
| "Bupivacaine treatment also decreased colony formation, migration, and invasion of HepG2 and SNU-449 cells." | 1.62 | Local anesthetic bupivacaine inhibits proliferation and metastasis of hepatocellular carcinoma cells via suppressing PI3K/Akt and MAPK signaling. ( Cai, X; Guan, H; Guo, W; Wang, L; Yan, N; Zhu, L, 2021) |
| "We present a case of persistent cortical blindness after a test dose of bupivacaine was administered into an uneventfully placed thoracic epidural catheter." | 1.36 | Persistent cortical blindness after a thoracic epidural test dose of bupivacaine. ( Groen, GJ; Kolling, JB; Rosseel, PM; Tetteroo, E; van der Meer, NJ; van Dijl, R; Visser, WA, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (16.67) | 18.7374 |
| 1990's | 3 (10.00) | 18.2507 |
| 2000's | 8 (26.67) | 29.6817 |
| 2010's | 8 (26.67) | 24.3611 |
| 2020's | 6 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Thuppal, S | 1 |
| Sleiman, A | 1 |
| Chawla, K | 1 |
| Dynda, D | 1 |
| Evans, Q | 1 |
| Markwell, S | 1 |
| Hazelrigg, S | 1 |
| Crabtree, T | 1 |
| Wu, HL | 1 |
| Tai, YH | 1 |
| Li, CC | 1 |
| Cata, JP | 2 |
| Wang, CW | 1 |
| Chang, KY | 1 |
| Tsou, MY | 1 |
| Lin, SP | 1 |
| NeMoyer, RE | 1 |
| Pantin, E | 1 |
| Aisner, J | 1 |
| Jongco, R | 1 |
| Mellender, S | 1 |
| Chiricolo, A | 1 |
| Moore, DF | 1 |
| Langenfeld, J | 1 |
| Weksler, B | 1 |
| Sullivan, JL | 1 |
| Schumacher, LY | 1 |
| Corsini, EM | 1 |
| Mitchell, KG | 1 |
| Zhou, N | 1 |
| Antonoff, MB | 1 |
| Mehran, RJ | 1 |
| Mena, GE | 1 |
| Rajaram, R | 1 |
| Roth, JA | 1 |
| Sepesi, B | 1 |
| Swisher, SG | 1 |
| Vaporciyan, AA | 1 |
| Walsh, GL | 1 |
| Rice, DC | 1 |
| Hofstetter, WL | 1 |
| Wang, L | 1 |
| Guo, W | 1 |
| Guan, H | 1 |
| Yan, N | 1 |
| Cai, X | 1 |
| Zhu, L | 1 |
| Chan, SM | 1 |
| Lin, BF | 1 |
| Wong, CS | 1 |
| Chuang, WT | 1 |
| Chou, YT | 1 |
| Wu, ZF | 1 |
| Gottumukkala, V | 1 |
| Thakar, D | 1 |
| Keerty, D | 1 |
| Gebhardt, R | 1 |
| Liu, DD | 1 |
| Nakanishi, M | 1 |
| Okura, N | 1 |
| Kashii, T | 1 |
| Matsushita, M | 1 |
| Mori, M | 1 |
| Yoshida, M | 1 |
| Tsujimura, S | 1 |
| Bentley, JN | 1 |
| Viswanathan, A | 1 |
| Rosenberg, WS | 1 |
| Patil, PG | 1 |
| Ried, M | 1 |
| Schilling, C | 1 |
| Potzger, T | 1 |
| Ittner, KP | 1 |
| Rupp, A | 1 |
| Szöke, T | 1 |
| Hofmann, HS | 1 |
| Diez, C | 1 |
| Fiorelli, A | 1 |
| Izzo, AC | 1 |
| Frongillo, EM | 1 |
| Del Prete, A | 1 |
| Liguori, G | 1 |
| Di Costanzo, E | 1 |
| Vicidomini, G | 1 |
| Santini, M | 1 |
| Blechman, KM | 1 |
| Zervos, M | 1 |
| Chaudhri, BB | 1 |
| Macfie, A | 1 |
| Kirk, AJ | 1 |
| Visser, WA | 1 |
| Kolling, JB | 1 |
| Groen, GJ | 1 |
| Tetteroo, E | 1 |
| van Dijl, R | 1 |
| Rosseel, PM | 1 |
| van der Meer, NJ | 1 |
| Tyrrell, JR | 1 |
| Trumpelmann, P | 1 |
| Chamberlain, MH | 1 |
| Mercadante, S | 1 |
| Villari, P | 1 |
| Ferrera, P | 1 |
| Arcuri, E | 1 |
| Tikuisis, R | 1 |
| Miliauskas, P | 1 |
| Zurauskas, A | 1 |
| Cicenas, S | 1 |
| Eidukevicius, R | 1 |
| Jackevicius, A | 1 |
| Luketich, JD | 1 |
| Land, SR | 1 |
| Sullivan, EA | 1 |
| Alvelo-Rivera, M | 1 |
| Ward, J | 1 |
| Buenaventura, PO | 1 |
| Landreneau, RJ | 1 |
| Hart, LA | 1 |
| Fernando, HC | 1 |
| Yoshioka, M | 1 |
| Mori, T | 1 |
| Kobayashi, H | 1 |
| Iwatani, K | 1 |
| Yoshimoto, K | 1 |
| Terasaki, H | 1 |
| Nomori, H | 1 |
| Ivani, G | 1 |
| Mossetti, V | 1 |
| Andreacchio, A | 1 |
| Lafont, ND | 1 |
| Legros, FJ | 1 |
| Boogaerts, JG | 1 |
| Page, GG | 1 |
| Blakely, WP | 1 |
| Ben-Eliyahu, S | 1 |
| Shuman, RL | 1 |
| Peters, RM | 1 |
| Aguilar, JL | 1 |
| Montes, A | 1 |
| Samper, D | 1 |
| Roca, G | 1 |
| Vidal, F | 1 |
| Klein, DS | 1 |
| Klein, PW | 1 |
| Fineman, SP | 1 |
| Cremonte, LG | 1 |
| Mantellini, E | 1 |
| Scheinin, B | 1 |
| Scheinin, M | 1 |
| Asantila, R | 1 |
| Lindberg, R | 1 |
| Viinamäki, O | 1 |
| Oxorn, DC | 1 |
| Landrigan, P | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Liposomal Bupivacaine Versus Bupivacaine for Postoperative Analgesia Following Video-assisted Thoracoscopic Surgery.[NCT03036085] | Phase 2/Phase 3 | 200 participants (Anticipated) | Interventional | 2017-02-28 | Not yet recruiting | ||
| Randomized Prospective Study Comparing Paravertebral Catheters, Single Shot Paravertebral Block, Thoracic Epidural, for Postoperative Analgesia Following Video-assisted Thoracoscopic Surgery[NCT03151434] | Phase 3 | 147 participants (Actual) | Interventional | 2017-02-07 | Completed | ||
| Supplementary Epidural Analgesia in Video-Assisted Thoracic Surgery (VATS) - The SEAVATS Study[NCT02359175] | Phase 4 | 161 participants (Actual) | Interventional | 2015-02-28 | Completed | ||
| Effects of Epidural Anesthesia-analgesia on Long-term Survival in Patients After Lung Cancer Surgery: A Randomized Controlled Trial[NCT02801409] | 400 participants (Actual) | Interventional | 2015-05-25 | Completed | |||
| Impact of Perioperative Dexmedetomidine on Long-term Survival in Older Patients After Cancer Surgery: a Multicenter Randomized Trial[NCT06030804] | 4,532 participants (Anticipated) | Interventional | 2023-09-12 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Nausea scores will be collected by a study team member post operatively up to 3 days per protocol. Nausea will be recorded as 0=none, 1=mild, 2=moderate, or 3=severe (NCT03151434)
Timeframe: Nausea scores will be documented at 1 hour post op, 24,48,and 72 hours after the surgery.The scores will then be averaged.
| Intervention | units on a scale (Mean) |
|---|---|
| Group #1 | 0.27 |
| Group #2 | 0.27 |
| Group #3 | 0.29 |
Sedation scores will be documented by a study team member post operatively up to 3 days per protocol requirements. Determining if patient is 0=awake and alert, 1=quietly awake, 2=asleep and arousable, or 3=deep sleep. (NCT03151434)
Timeframe: Sedation scores will be documented at 1 hour post op, 24,48,and 72 hours after the sugery. The scores will then be averaged.
| Intervention | units on a scale (Mean) |
|---|---|
| Group #1 | 0.38 |
| Group #2 | 0.32 |
| Group #3 | 0.22 |
Opioid consumption will be collected by a study team member post operatively up to 3 days per protocol time requirements (NCT03151434)
Timeframe: Opioid consumption will be measured at 1 hour post op, 24,48, and 72 hours post op. The total amount will be recorded.
| Intervention | miligram morphine equivalent (Median) |
|---|---|
| Group #1 | 57 |
| Group #2 | 35 |
| Group #3 | 21.3 |
Subjects will be followed up at 24 hours post operatively by a study team member to document patient overall satisfaction scores. Score was recorded as 0=dissatisfied, 1=satisfied, 2=very satisfied. (NCT03151434)
Timeframe: post operatively at hour 24
| Intervention | units on a scale (Mean) |
|---|---|
| Group #1 | 0.89 |
| Group #2 | 0.95 |
| Group #3 | 1.33 |
Subjects will be followed up at 48 hours post operatively by a study team member to document patient overall satisfaction scores. Scores will be recorded as 0=dissatisfied, 1=satisfied, 2=very satisfied. (NCT03151434)
Timeframe: post operatively at hour 48
| Intervention | units on a scale (Mean) |
|---|---|
| Group #1 | 1.19 |
| Group #2 | 1.05 |
| Group #3 | 1.32 |
"The VAS score will be taken with both rest and movement (knee flexion) and will be measured by a study team investigator using Visual Analog Scale (VAS). Using units on a scale of 1-10 for documentation with 10 being the worst pain and 0 being no pain" (NCT03151434)
Timeframe: Pain scores will be measured 24 hours after surgery.
| Intervention | units on a scale (Median) |
|---|---|
| US Guided Single Shot Paravertebral Block | 4.0 |
| US Guided Paravertebral Catheter | 4.5 |
| Thoracic Epidural | 3.0 |
"The VAS scores will be taken with both rest and movement (knee flexion) and will be measured by a study team investigator using Visual Analog Scale (VAS). Usingunits on a scale scale of 1-10 for documentation with 10 being the worst pain and 0 being no pain" (NCT03151434)
Timeframe: Pain scores will be measured 48 hours after surgery.
| Intervention | units on a scale (Median) |
|---|---|
| US Guided Single Shot Paravertebral Block | 3.0 |
| US Guided Paravertebral Catheter | 4.0 |
| Thoracic Epidural | 2.0 |
1 review available for bupivacaine and Lung Neoplasms
| Article | Year |
|---|---|
Treatment of medically refractory cancer pain with a combination of intrathecal neuromodulation and neurosurgical ablation: case series and literature review.
Topics: Adolescent; Aged; Bone Neoplasms; Bupivacaine; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell | 2014 |
7 trials available for bupivacaine and Lung Neoplasms
| Article | Year |
|---|---|
Randomized Trial of Bupivacaine Versus Liposomal Bupivacaine in Minimally Invasive Lobectomy.
Topics: Adult; Aged; Anesthetics, Local; Bupivacaine; Epinephrine; Female; Humans; Liposomes; Lung Neoplasms | 2022 |
Randomized trial of bupivacaine with epinephrine versus bupivacaine liposome suspension in patients undergoing minimally invasive lung resection.
Topics: Aged; Anesthetics, Local; Bronchodilator Agents; Bupivacaine; Epinephrine; Female; Humans; Length of | 2021 |
Prospective, comparative study of the On-Q® PainBuster® postoperative pain relief system and thoracic epidural analgesia after thoracic surgery.
Topics: Amides; Analgesia, Epidural; Analgesia, Patient-Controlled; Anesthetics, Local; Bupivacaine; Dose-Re | 2014 |
Efficacy of wound analgesia for controlling post-thoracotomy pain: a randomized double-blind study†.
Topics: Aged; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthetics, Local; Bupivacaine; Carcinoma, | 2016 |
Thoracic epidural versus intercostal nerve catheter plus patient-controlled analgesia: a randomized study.
Topics: Adult; Aged; Aged, 80 and over; Analgesia, Patient-Controlled; Anesthesia, Epidural; Anesthetics, Lo | 2005 |
The efficacy of epidural analgesia after video-assisted thoracoscopic surgery: a randomized control study.
Topics: Analgesia, Epidural; Analgesics, Opioid; Anesthetics, Local; Bupivacaine; Catheterization; Fentanyl; | 2006 |
The efficacy of epidural analgesia after video-assisted thoracoscopic surgery: a randomized control study.
Topics: Analgesia, Epidural; Analgesics, Opioid; Anesthetics, Local; Bupivacaine; Catheterization; Fentanyl; | 2006 |
The efficacy of epidural analgesia after video-assisted thoracoscopic surgery: a randomized control study.
Topics: Analgesia, Epidural; Analgesics, Opioid; Anesthetics, Local; Bupivacaine; Catheterization; Fentanyl; | 2006 |
The efficacy of epidural analgesia after video-assisted thoracoscopic surgery: a randomized control study.
Topics: Analgesia, Epidural; Analgesics, Opioid; Anesthetics, Local; Bupivacaine; Catheterization; Fentanyl; | 2006 |
Sympatho-adrenal and pituitary hormone responses during and immediately after thoracic surgery--modulation by four different pain treatments.
Topics: Aged; Anesthesia, Conduction; Anesthesia, Epidural; Bupivacaine; Catecholamines; Female; Growth Horm | 1987 |
22 other studies available for bupivacaine and Lung Neoplasms
| Article | Year |
|---|---|
Dose-response relationship between epidural bupivacaine dose and mortality risk after surgical resection of nonsmall-cell lung cancer.
Topics: Analgesia, Epidural; Anesthetics, Local; Bupivacaine; Carcinoma, Non-Small-Cell Lung; Cohort Studies | 2022 |
Paravertebral Nerve Block With Liposomal Bupivacaine for Pain Control Following Video-Assisted Thoracoscopic Surgery and Thoracotomy.
Topics: Aged; Anesthetics, Local; Bupivacaine; Epinephrine; Female; Humans; Lung Neoplasms; Male; Middle Age | 2020 |
Liposomal Bupivacaine Intercostal Block Is Important for Reduction of Pulmonary Complications.
Topics: Aged; Anesthetics, Local; Bupivacaine; Female; Follow-Up Studies; Humans; Incidence; Intercostal Ner | 2021 |
Local anesthetic bupivacaine inhibits proliferation and metastasis of hepatocellular carcinoma cells via suppressing PI3K/Akt and MAPK signaling.
Topics: Anesthetics, Local; Animals; Apoptosis; Bupivacaine; Carcinoma, Hepatocellular; Cell Movement; Cell | 2021 |
Levobuipivacaine-Induced Dissemination of A549 Lung Cancer Cells.
Topics: A549 Cells; Anesthetics, Local; Animals; Basic Helix-Loop-Helix Transcription Factors; Bupivacaine; | 2017 |
Effects of postoperative epidural analgesia on recurrence-free and overall survival in patients with nonsmall cell lung cancer.
Topics: Age Factors; Aged; Amides; Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesics, Opioid; A | 2014 |
[Case of lymphangioleiomyomatosis (LAM) discovered during cesarean section under spinal anesthesia].
Topics: Adult; Anesthesia, Obstetrical; Anesthesia, Spinal; Bupivacaine; Cesarean Section; Female; Humans; H | 2014 |
Post-thoracotomy Horner syndrome associated with extrapleural infusion of local anesthetic.
Topics: Adenocarcinoma; Anesthetics, Local; Bupivacaine; Carcinoma, Non-Small-Cell Lung; Female; Horner Synd | 2009 |
Inadvertent total spinal anesthesia after intercostal nerve block placement during lung resection.
Topics: Aged; Anesthesia, Spinal; Bupivacaine; Carcinoma, Non-Small-Cell Lung; Follow-Up Studies; Humans; In | 2009 |
Persistent cortical blindness after a thoracic epidural test dose of bupivacaine.
Topics: Anesthesia, Epidural; Anesthetics, Local; Blindness, Cortical; Bupivacaine; Carcinoma, Large Cell; C | 2010 |
Harlequin syndrome after extrapleural bupivacaine infusion.
Topics: Adenocarcinoma; Aged; Anesthetics, Local; Autonomic Nervous System Diseases; Bupivacaine; Flushing; | 2012 |
Local anesthetic switching for intrathecal tachyphylaxis in cancer patients with pain.
Topics: Adult; Anesthetics, Local; Bupivacaine; Carcinoma, Small Cell; Endometrial Neoplasms; Female; Humans | 2003 |
[Hypotensive epidural anesthesia in thoracic surgery].
Topics: Adult; Aged; Analgesics, Opioid; Anesthesia, Epidural; Anesthesia, General; Anesthetics, Local; Bloo | 2004 |
Ultrasound-guided peripheral catheter placement for upper limb amputation in a 12-year-old boy: possible phantom limb pain prevention?
Topics: Amputation, Surgical; Anesthetics, Inhalation; Anesthetics, Intravenous; Anesthetics, Local; Bone Ne | 2008 |
Use of liposome-associated bupivacaine in a cancer pain syndrome.
Topics: Aged; Analgesia, Epidural; Anesthetics, Local; Bupivacaine; Drug Carriers; Humans; Liposomes; Lung N | 1996 |
Evidence that postoperative pain is a mediator of the tumor-promoting effects of surgery in rats.
Topics: Adenocarcinoma; Analgesics, Opioid; Anesthetics, Local; Animals; Antiviral Agents; Bupivacaine; Expl | 2001 |
Evidence that postoperative pain is a mediator of the tumor-promoting effects of surgery in rats.
Topics: Adenocarcinoma; Analgesics, Opioid; Anesthetics, Local; Animals; Antiviral Agents; Bupivacaine; Expl | 2001 |
Evidence that postoperative pain is a mediator of the tumor-promoting effects of surgery in rats.
Topics: Adenocarcinoma; Analgesics, Opioid; Anesthetics, Local; Animals; Antiviral Agents; Bupivacaine; Expl | 2001 |
Evidence that postoperative pain is a mediator of the tumor-promoting effects of surgery in rats.
Topics: Adenocarcinoma; Analgesics, Opioid; Anesthetics, Local; Animals; Antiviral Agents; Bupivacaine; Expl | 2001 |
Epidural anesthesia following thoracotomy in patients with chronic obstructive airway disease.
Topics: Aged; Anesthesia, Epidural; Bupivacaine; Chronic Disease; Epinephrine; Humans; Lung Diseases, Obstru | 1976 |
Interpleural analgesia through a DuPen catheter for lung cancer pain.
Topics: Bupivacaine; Catheterization; Humans; Lung Neoplasms; Male; Middle Aged; Pain, Intractable; Pleura | 1992 |
Intermittent interpleural injection of bupivacaine and methylprednisolone for analgesia in metastatic thoracic neoplasm.
Topics: Breast Neoplasms; Bupivacaine; Carcinoma, Small Cell; Chronic Disease; Female; Humans; Lung Neoplasm | 1991 |
Long-term post-thoracotomy cancer pain management with interpleural bupivacaine.
Topics: Bupivacaine; Female; Humans; Lung Neoplasms; Middle Aged; Neoplasm Metastasis; Pain, Intractable; Pa | 1989 |
[Morphine combined with marcaine in long-term epidural analgesia in patients with Pancoast's syndrome caused by bronchogenic carcinoma of the apex of the lung].
Topics: Aged; Analgesia, Epidural; Bupivacaine; Carcinoma, Bronchogenic; Evaluation Studies as Topic; Female | 1989 |
Anaesthetic management for oophorectomy in pulmonary lymphangiomyomatosis.
Topics: Adult; Anesthesia, Epidural; Bupivacaine; Female; Glucocorticoids; Humans; Lung Diseases, Obstructiv | 1987 |