Page last updated: 2024-10-24

bupivacaine and Leiomyoma

bupivacaine has been researched along with Leiomyoma in 5 studies

Bupivacaine: A widely used local anesthetic agent.
1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide : A piperidinecarboxamide obtained by formal condensation of the carboxy group of N-butylpipecolic acid with the amino group of 2,6-dimethylaniline.
bupivacaine : A racemate composed of equimolar amounts of dextrobupivacaine and levobupivacaine. Used (in the form of its hydrochloride hydrate) as a local anaesthetic.

Leiomyoma: A benign tumor derived from smooth muscle tissue, also known as a fibroid tumor. They rarely occur outside of the UTERUS and the GASTROINTESTINAL TRACT but can occur in the SKIN and SUBCUTANEOUS TISSUE, probably arising from the smooth muscle of small blood vessels in these tissues.

Research Excerpts

Excerpt	Relevance	Reference
"Sixty premenopausal women with uterine leiomyomata were enrolled in a randomized controlled design and intraoperatively treated with injection of bupivacaine plus epinephrine (group A) or saline solution (group B) during laparoscopic myomectomy."	5.11	Bupivacaine plus epinephrine for laparoscopic myomectomy: a randomized placebo-controlled trial. ( Barletta, E; Corea, D; Doldo, P; Falbo, A; Palomba, S; Pellicano, M; Russo, T; Saraco, P; Zullo, F; Zupi, E, 2004)

Research

Studies (5)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	2 (40.00)	29.6817
2010's	3 (60.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Selvi, O	1
Tulgar, S	1
Powell, MF	1
Sakawi, Y	1
El Hachem, L	1
Small, E	1
Chung, P	1
Moshier, EL	1
Friedman, K	1
Fenske, SS	1
Gretz, HF	1
Seki, H	1
Takizawa, Y	1
Sodemoto, T	1
Zullo, F	1
Palomba, S	1
Corea, D	1
Pellicano, M	1
Russo, T	1
Falbo, A	1
Barletta, E	1
Saraco, P	1
Doldo, P	1
Zupi, E	1

Clinical Trials (1)

Trial Overview

Trial			Phase	Enrollment	Study Type	Start Date	Status
Analgesic Efficacy of Transversus Abdominis Plane Block Versus Local Injection in Postoperative Pain Management Following Minimally Invasive Gynecological Surgery[NCT02314104]				220 participants (Actual)	Interventional	2011-05-31	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Postoperative Pain on a Visual Analogue Pain Scale at One Hour Postoperatively

A Visual Analogue Scale was used. The scale range was 0 to 10 in increments of one. 0 was no pain and 10 was worst pain possible. (NCT02314104)
Timeframe: one hour postoperatively

Intervention	units on a scale (Mean)
Treatment TAP, Placebo Local Injection	4.04
Placebo TAP, Treatment Local Injection	5.09
Treatment TAP, Treatment Local Injection	4.4

Postoperative Pain on a Visual Analogue Pain Scale at Six Hours Postoperatively

A Visual Analogue Scale was used. The scale range was 0 to 10 in increments of one. 0 was no pain and 10 was worst pain possible. (NCT02314104)
Timeframe: six hours postoperatively

Intervention	units on a scale (Mean)
Treatment TAP, Placebo Local Injection	3.53
Placebo TAP, Treatment Local Injection	3.5
Treatment TAP, Treatment Local Injection	3.33

Postoperative Pain on a Visual Analogue Pain Scale at Twenty-four Hours Postoperatively

A Visual Analogue Scale was used. The scale range was 0 to 10 in increments of one. 0 was no pain and 10 was worst pain possible. (NCT02314104)
Timeframe: twenty-four hours postoperatively

Intervention	units on a scale (Mean)
Treatment TAP, Placebo Local Injection	3.36
Placebo TAP, Treatment Local Injection	3.56
Treatment TAP, Treatment Local Injection	3.51

Time Until First Request for Pain Medication

(NCT02314104)
Timeframe: up to twenty-four hours postoperatively

Intervention	minutes (Median)
Treatment TAP, Placebo Local Injection	46
Placebo TAP, Treatment Local Injection	31
Treatment TAP, Treatment Local Injection	28

Total Narcotic Usage in Morphine Equivalents

(NCT02314104)
Timeframe: up to twenty-four hours postoperatively

Intervention	mg (Mean)
Treatment TAP, Placebo Local Injection	20.09
Placebo TAP, Treatment Local Injection	23.14
Treatment TAP, Treatment Local Injection	20.68

Trials

2 trials available for bupivacaine and Leiomyoma

Article	Year
Randomized controlled double-blind trial of transversus abdominis plane block versus trocar site infiltration in gynecologic laparoscopy. American journal of obstetrics and gynecology, 2015, Volume: 212, Issue:2 Topics: Abdominal Muscles; Adult; Aged; Anesthesia, Local; Anesthetics, Local; Bupivacaine; Cohort Studies;	2015
Bupivacaine plus epinephrine for laparoscopic myomectomy: a randomized placebo-controlled trial. Obstetrics and gynecology, 2004, Volume: 104, Issue:2 Topics: Adult; Anesthetics, Local; Bupivacaine; Double-Blind Method; Epinephrine; Female; Humans; Injections	2004

Other Studies

3 other studies available for bupivacaine and Leiomyoma

Article	Year
Ultrasound guided erector spinae plane block as a cause of unintended motor block. Revista espanola de anestesiologia y reanimacion, 2018, Volume: 65, Issue:10 Topics: Adult; Analgesia, Obstetrical; Bupivacaine; Cesarean Section; Diffusion; Female; Gait Disorders, Neu	2018
Aortocaval compression during early pregnancy: are there other causes? International journal of obstetric anesthesia, 2013, Volume: 22, Issue:2 Topics: Adult; Analgesia, Epidural; Analgesics, Opioid; Anesthetics, Local; Aorta, Thoracic; Bupivacaine; Fe	2013
Epidural analgesia for painful myomas refractory to medical therapy during pregnancy. International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 2003, Volume: 83, Issue:3 Topics: Adult; Analgesia, Epidural; Biological Availability; Bupivacaine; Female; Humans; Leiomyoma; Materna	2003