bupivacaine has been researched along with Injuries, Knee in 24 studies
Bupivacaine: A widely used local anesthetic agent.
1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide : A piperidinecarboxamide obtained by formal condensation of the carboxy group of N-butylpipecolic acid with the amino group of 2,6-dimethylaniline.
bupivacaine : A racemate composed of equimolar amounts of dextrobupivacaine and levobupivacaine. Used (in the form of its hydrochloride hydrate) as a local anaesthetic.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Postoperative knee chondrolysis caused by continuous intra-articular pain pumps infusing bupivacaine with epinephrine is a rare but serious complication." | 7.81 | Knee chondrolysis by infusion of bupivacaine with epinephrine through an intra-articular pain pump catheter after arthroscopic ACL reconstruction. ( Buchko, JZ; Gurney-Dunlop, T; Shin, JJ, 2015) |
| "Postoperative knee chondrolysis caused by continuous intra-articular pain pumps infusing bupivacaine with epinephrine is a rare but serious complication." | 3.81 | Knee chondrolysis by infusion of bupivacaine with epinephrine through an intra-articular pain pump catheter after arthroscopic ACL reconstruction. ( Buchko, JZ; Gurney-Dunlop, T; Shin, JJ, 2015) |
| "This requires a patient friendly postoperative pain management." | 2.73 | Pre- versus postoperative intraarticular application of local anesthetics and opioids versus femoral nerve block in anterior cruciate ligament repair. ( Entholzner, E; Hein, W; Hube, R; Mayr, HO; Weig, TG, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (8.33) | 18.7374 |
| 1990's | 7 (29.17) | 18.2507 |
| 2000's | 7 (29.17) | 29.6817 |
| 2010's | 8 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Astur, DC | 1 |
| Aleluia, V | 1 |
| Veronese, C | 1 |
| Astur, N | 1 |
| Oliveira, SG | 1 |
| Arliani, GG | 1 |
| Badra, R | 1 |
| Kaleka, CC | 1 |
| Amaro, JT | 1 |
| Cohen, M | 1 |
| Buchko, JZ | 1 |
| Gurney-Dunlop, T | 1 |
| Shin, JJ | 1 |
| Van Le, B | 1 |
| Harish, S | 1 |
| Schuster, M | 1 |
| Engelhardt, L | 1 |
| Erler, W | 1 |
| Dienert, B | 1 |
| Wagner, M | 1 |
| Birnbaum, J | 1 |
| Volk, T | 1 |
| Mitra, S | 1 |
| Kaushal, H | 1 |
| Gupta, RK | 1 |
| Gądek, A | 1 |
| Wordliczek, J | 1 |
| Zajaczkowska, R | 1 |
| Noyes, FR | 1 |
| Fleckenstein, CM | 1 |
| Barber-Westin, SD | 1 |
| Burks, RT | 1 |
| Yari, M | 1 |
| Saeb, M | 1 |
| Golfam, P | 1 |
| Makhloogh, Z | 1 |
| Mayr, HO | 1 |
| Entholzner, E | 1 |
| Hube, R | 1 |
| Hein, W | 1 |
| Weig, TG | 1 |
| Sibanda, S | 1 |
| Hughes, JM | 1 |
| Pawson, PE | 1 |
| Kelly, G | 1 |
| Bellenger, CR | 1 |
| Charalambous, CP | 1 |
| Tryfonidis, M | 1 |
| Alvi, F | 1 |
| Kumar, R | 1 |
| Hirst, P | 1 |
| Sekhon, JS | 1 |
| Anderson, K | 1 |
| Schär, B | 1 |
| Boden, BP | 1 |
| Fassler, S | 1 |
| Cooper, S | 1 |
| Marchetto, PA | 1 |
| Moyer, RA | 1 |
| Ateş, Y | 2 |
| Kinik, H | 1 |
| Bínnet, MS | 1 |
| Canakçi, N | 1 |
| Keçik, Y | 1 |
| Cappellino, A | 1 |
| Jokl, P | 1 |
| Ruwe, PA | 1 |
| Iaquinto, JM | 1 |
| Pienkowski, D | 1 |
| Thornsberry, R | 1 |
| Grant, S | 1 |
| Stevens, DB | 1 |
| Lundin, O | 1 |
| Rydgren, B | 1 |
| Swärd, L | 1 |
| Karlsson, J | 1 |
| Follak, N | 1 |
| Ganzer, D | 1 |
| Liguori, GA | 1 |
| Chimento, GF | 1 |
| Borow, L | 1 |
| Figgie, M | 1 |
| Broadman, L | 1 |
| Hannallah, R | 1 |
| DeLeon, E | 1 |
| Reff, R | 1 |
| Johnson, PW | 1 |
| Carpenter, RL | 1 |
| Ulrich, C | 1 |
| Burri, C | 1 |
| Wörsdörfer, O | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Comparison of the Effect of Intra-articular Administration of 2% Ropivacaine vs. 7.5% Ropivacaine as an Analgesic in the Immediate Postoperative Period of Knee Arthroscopy in Acute Injuries at the ABC Medical Center[NCT05807945] | Phase 4 | 68 participants (Actual) | Interventional | 2020-04-01 | Completed | ||
| Prospective Assessment of Intraoperative Intra-articular Morphine and Clonidine Injection in Hip Arthroscopy on Postoperative Pain Management[NCT02530151] | Phase 4 | 70 participants (Actual) | Interventional | 2015-11-30 | Completed | ||
| Effect of Volume of Local Anesthetic for Adductor Canal Block on Quadriceps Muscle Function: A Dose Finding Study[NCT02541552] | Phase 3 | 26 participants (Actual) | Interventional | 2015-04-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The total usage of opioid medication (mEq) for pain relief in the intraoperative period and again through the postoperative recovery period from arrival in the PACU through 7 days post op (NCT02530151)
Timeframe: Recorded intraoperatively, during PACU stay, 6 hours post discharge, 18 hours post discharge, 24 hours post discharge, 48 hours post discharge, and at 7 days post discharge
| Intervention | milligram morphine equivalents (mEq) (Mean) | ||||||
|---|---|---|---|---|---|---|---|
| Intraoperative | PACU | 6 hours Post Discharge | 18 hours Post Discharge | 24 hours Post Discharge | 48 hours Post Discharge | 7 days Post Discharge | |
| Morphine With Clonidine | 57.3 | 37.0 | 5.5 | 14.5 | 19.5 | 27.7 | 50.7 |
| Normal Saline | 56.0 | 40.1 | 5.3 | 13.8 | 20.0 | 35.6 | 73.8 |
The Quality of Recovery questionnaire (QoR-15) is a 15 question patient reported outcome measure used to evaluate the quality of recovery following surgical anesthesia concerning pain, physical function, and psychological factors; reported as a summative score with each question graded between 0-10 (Range:0-150) with higher scores indicating improved physical/psychological recovery or infrequent symptoms (NCT02530151)
Timeframe: Preoperative to 24 hrs. post operatively
| Intervention | score on a scale (Mean) | |
|---|---|---|
| Preoperative QoR-15 Score | Change in QoR-15 Score at 24 hrs. Post Op | |
| Morphine With Clonidine | 123 | -22 |
| Normal Saline | 131 | -20 |
Patients will rate their pain (0-10) on the Visual Analog Scale with higher scores for the VAS indicated elevated pain intensity reported by the patient for the indicated time point (NCT02530151)
Timeframe: Immediately preoperative (5-10 minutes before surgery), immediately postoperative (5-10 minutes after surgery), 1 hr post operatively
| Intervention | score on a scale (Mean) | ||
|---|---|---|---|
| Preoperative VAS Pain Score | Immediate Post Op VAS Pain Score | 1 hr. Post Op VAS Pain Score | |
| Morphine With Clonidine | 2 | 3 | 4 |
| Normal Saline | 2 | 4 | 5 |
12 trials available for bupivacaine and Injuries, Knee
| Article | Year |
|---|---|
A prospective double blinded randomized study of anterior cruciate ligament reconstruction with hamstrings tendon and spinal anesthesia with or without femoral nerve block.
Topics: Adolescent; Adult; Amides; Anesthesia, Spinal; Anesthetics, Local; Anterior Cruciate Ligament; Anter | 2014 |
[Levobupivacaine vs. ropivacaine for continuous femoral analgesia after anterior cruciate ligament reconstruction].
Topics: Adult; Amides; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthetics, Local; Anterior Cruci | 2011 |
Evaluation of analgesic efficacy of intra-articular bupivacaine, bupivacaine plus fentanyl, and bupivacaine plus tramadol after arthroscopic knee surgery.
Topics: Adult; Analgesia; Analgesics, Opioid; Anesthetics, Local; Arthroscopy; Bupivacaine; Double-Blind Met | 2011 |
Analgesic efficacy of intra-articular morphine after arthroscopic knee surgery in sport injury patients.
Topics: Adult; Analgesics, Opioid; Anesthetics, Local; Anterior Cruciate Ligament; Anterior Cruciate Ligamen | 2013 |
Pre- versus postoperative intraarticular application of local anesthetics and opioids versus femoral nerve block in anterior cruciate ligament repair.
Topics: Administration, Oral; Adult; Ambulatory Surgical Procedures; Analgesia; Analgesics, Opioid; Anesthes | 2007 |
The effects of preoperative extradural bupivacaine and morphine on the stress response in dogs undergoing femoro-tibial joint surgery.
Topics: Analgesics, Opioid; Anesthesia, Spinal; Anesthetics, Local; Animals; Anterior Cruciate Ligament; Ant | 2006 |
Purely intra-articular versus general anesthesia for proposed arthroscopic partial meniscectomy of the knee: a randomized controlled trial.
Topics: Adult; Alfentanil; Anesthesia, General; Anesthetics, Local; Arthroscopy; Bupivacaine; Epinephrine; F | 2006 |
Analgesic effect of intraarticular morphine, bupivacaine, and morphine/bupivacaine after arthroscopic knee surgery.
Topics: Adult; Arthroscopy; Bupivacaine; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Inj | 1994 |
Comparison of prilocaine and bupivacaine for post-arthroscopy analgesia: a placebo-controlled double-blind trial.
Topics: Adult; Arthroscopy; Bupivacaine; Double-Blind Method; Female; Humans; Injections, Intra-Articular; K | 1994 |
Analgesic effects of intra-articular morphine during and after knee arthroscopy: a comparison of two methods.
Topics: Adult; Analgesics, Opioid; Anesthetics, Local; Arthroscopy; Bupivacaine; Endoscopy; Female; Humans; | 1998 |
Postoperative analgesic value of the intra-articular instillation of bupivacaine and morphine after arthroscopic knee surgery.
Topics: Analgesics, Opioid; Anesthetics, Local; Anterior Cruciate Ligament; Anterior Cruciate Ligament Injur | 2001 |
Intra-articular bupivacaine does not decrease narcotic requirements after arthroscopic surgery in adolescents.
Topics: Adolescent; Anesthesia, Inhalation; Anesthesia, Local; Arthroscopy; Bupivacaine; Double-Blind Method | 1990 |
12 other studies available for bupivacaine and Injuries, Knee
| Article | Year |
|---|---|
Knee chondrolysis by infusion of bupivacaine with epinephrine through an intra-articular pain pump catheter after arthroscopic ACL reconstruction.
Topics: Adolescent; Adult; Anesthetics, Local; Anterior Cruciate Ligament Reconstruction; Arthralgia; Arthro | 2015 |
Quadriceps fat pad edema: sonographic depiction and sonographically guided steroid injection.
Topics: Adipose Tissue; Anesthetics, Local; Anti-Inflammatory Agents; Bupivacaine; Edema; Humans; Injections | 2009 |
Evaluation of analgesic efficacy of intra-articular opioids (morphine, fentanyl) after arthroscopic knee surgery.
Topics: Analgesia; Arthroscopy; Bupivacaine; Female; Fentanyl; Humans; Knee Injuries; Male; Pain, Postoperat | 2012 |
The development of postoperative knee chondrolysis after intra-articular pain pump infusion of an anesthetic medication: a series of twenty-one cases.
Topics: Adolescent; Adult; Arthralgia; Bupivacaine; Cartilage Diseases; Cartilage, Articular; Drug Combinati | 2012 |
Chondrolysis is not just a shoulder problem anymore: commentary on an article by Frank R. Noyes, MD, et al.: “The development of postoperative knee chondrolysis after intra-articular pain pump infusion of an anesthetic medication. A series of twenty-one c
Topics: Bupivacaine; Cartilage Diseases; Female; Humans; Injections, Intra-Articular; Knee Injuries; Male; P | 2012 |
Rupture of the distal semitendinosus tendon: a report of two cases in professional athletes.
Topics: Adult; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Baseball; Bupivacaine; Cryothera | 2007 |
[Anesthesia in a patient with hereditary angioedema].
Topics: Adult; Anesthesia, Epidural; Anesthesia, Inhalation; Angioedema; Bupivacaine; Halothane; Humans; Kne | 1984 |
Regional anesthesia in knee arthroscopy: a new technique involving femoral and sciatic nerve blocks in knee arthroscopy.
Topics: Adult; Anesthesia, Conduction; Anesthetics, Local; Anterior Cruciate Ligament; Anterior Cruciate Lig | 1996 |
Increased neurologic complications associated with postoperative epidural analgesia after tibial fracture fixation.
Topics: Adult; Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthetics, Local; B | 1997 |
Possible bupivacaine toxicity after intraarticular injection for postarthroscopic analgesia of the knee: implications of the surgical procedure.
Topics: Adult; Anesthetics, Local; Arthroscopy; Bupivacaine; Humans; Injections, Intra-Articular; Knee Injur | 2002 |
Temporary increase in leg pain resulting from lumbar sympathetic blockade.
Topics: Adult; Bupivacaine; Female; Humans; Knee Injuries; Leg; Lumbosacral Region; Nerve Block; Pain; Recur | 1990 |
[Postoperative knee joint mobilization in catheter peridural anesthesia following arthrolyses of the knee joint].
Topics: Adolescent; Adult; Aged; Anesthesia, Epidural; Arthritis, Infectious; Bupivacaine; Catheterization; | 1985 |