bupivacaine has been researched along with Inguinal Hernia in 248 studies
Bupivacaine: A widely used local anesthetic agent.
1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide : A piperidinecarboxamide obtained by formal condensation of the carboxy group of N-butylpipecolic acid with the amino group of 2,6-dimethylaniline.
bupivacaine : A racemate composed of equimolar amounts of dextrobupivacaine and levobupivacaine. Used (in the form of its hydrochloride hydrate) as a local anaesthetic.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study compared the transversus abdominis plane (TAP) block with bupivacaine and dexmedetomidine to the same mixture in the caudal block in delivering postoperative analgesia in children after unilateral inguinal hernia surgery." | 9.69 | Transversus abdominis plane block versus caudal block with bupivacaine and dexmedetomidine for unilateral inguinal hernia repair in pediatric patients: a randomized clinical trial. ( Abdelrady, MM; Abo El Fadl, GM; Anwar, M; Ismael, WA; Osman, HM; Sabra, T, 2023) |
| " The purpose of this study is to compare the efficacy of US-guided TAPB at two different concentrations of bupivacaine in pediatrics undergoing unilateral inguinal hernia repair." | 9.51 | Transversus abdominis plane block with different bupivacaine concentrations in children undergoing unilateral inguinal hernia repair: a single-blind randomized clinical trial. ( Atasever, AG; Bingül, ES; Çiftçi, HŞ; Dinçer, MB; Karadeniz, MS; Salviz, EA; Sungur, MO, 2022) |
| "25% levobupivacaine caudally administered on the effect of intra- and postoperative analgesia in children undergoing orchidopexy and inguinal hernia repair." | 9.24 | A Comparison of Three Different Volumes of Levobupivacaine for Caudal Block in Children Undergoing Orchidopexy and Inguinal Hernia Repair. ( Budic, I; Marjanovic, V; Simic, D; Stevic, M, 2017) |
| "To determine the difference in analgesic requirement in terms of mean postoperative narcotic consumption and mean postoperative pain score in patients undergoing unilateral inguinal hernia repair with or without bupivacaine infiltration as day-care patients." | 9.22 | Effects of bupivacaine infiltration on postoperative tramadol consumption in elective day care unilateral inguinal hernia repair. ( Khan, FA; Qureshi, RM, 2016) |
| "The study evaluated the clinical intraoperative effects of intrathecal administration of fentanyl on shoulder tip pain in patients undergoing laparoscopic total extraperitoneal inguinal hernia repair (TEP) under spinal anaesthesia." | 9.17 | Clinical effects of intrathecal fentanyl on shoulder tip pain in laparoscopic total extraperitoneal inguinal hernia repair under spinal anaesthesia: a double-blind, prospective, randomized controlled trial. ( Cho, CK; Kang, PS; Kim, MS; Kim, SH; Kwon, WK; Lee, SE; Park, DH; Sung, TY; Woo, NS, 2013) |
| "In the absence of any study on the use of bupivacaine as a long acting local anesthetic for the purpose of inducing preemptive analgesia in patients undergoing inguinal hernia repair under spinal anesthesia, this study was conducted to provide some evidence for possible benefits of such practice." | 9.17 | The effect of preemptive analgesia with bupivacaine on postoperative pain of inguinal hernia repair under spinal anesthesia: a randomized clinical trial. ( Akhondzadeh, R; Nazaree, E; Nesioonpour, Sh; Pipelzadeh, MR; Rezaee, S; Soleymani, M, 2013) |
| "Caudal bupivacaine is widely used for inguinal hernia repair in children, but often cannot totally eliminate responses to hernial sac traction." | 9.17 | Caudal dexmedetomidine combined with bupivacaine inhibit the response to hernial sac traction in children undergoing inguinal hernia repair. ( Huang, DY; Liu, YX; Luo, T; Wang, GH; Xiang, Q; Zhao, YL; Zhong, L, 2013) |
| "The present study compared the postoperative analgesic effects of preincisional and postincisional wound infiltration with levobupivacaine and postoperative cortisol and prolactin levels in children following inguinal hernia repair." | 9.14 | Effects of levobupivacaine infiltration on postoperative analgesia and stress response in children following inguinal hernia repair. ( Cevizci, N; Cnar, SO; Kayaoglu, S; Kum, U; Oba, S, 2009) |
| " However, there was a significant reduction of postoperative pain in the bupivacaine group as well at rest as coughing." | 9.14 | [Efficiency of bupivacaine wound subfasciale infiltration in reduction of postoperative pain after inguinal hernia surgery]. ( Atmani, M; Azendour, H; Belyamani, L; Bensghir, M; Drissi Kamili, N; Elmoqaddem, A; Massou, S; Mounir, K, 2010) |
| "kg(-1) added to bupivacaine significantly improves the quality of intraoperative analgesia and prolongs postoperative analgesia in children undergoing inguinal hernia repair with spinal anesthesia." | 9.14 | Effects of intrathecal fentanyl on quality of spinal anesthesia in children undergoing inguinal hernia repair. ( Apiliogullari, S; Duman, A; Duman, I, 2010) |
| "The aim of the study is to evaluate the efficacy of post-incisional wound infiltration with levobupivacaine in preventing the postoperative pain associated with inguinal hernia repair in children." | 9.12 | Wound infiltration with levobupivacaine: an alternative method of postoperative pain relief after inguinal hernia repair in children. ( Kostopanagiotou, G; Matsota, P; Papageorgiou-Brousta, M, 2007) |
| "We have compared ropivacaine with bupivacaine and lidocaine for ilioinguinal block in thirty children undergoing ambulatory inguinal hernia repair." | 9.11 | Comparison of ropivacaine with bupivacaine and lidocaine for ilioinguinal block after ambulatory inguinal hernia repair in children. ( Ichizawa, M; Shinomura, T; Tsuchiya, N; Yoshikawa, Y, 2004) |
| "Preperitoneal Bupivacaine attenuates pain following laparoscopic inguinal hernia repair and should be considered in these cases." | 9.11 | Preperitoneal bupivacaine attenuates pain following laparoscopic inguinal hernia repair. ( Ayalon, A; Bar-Dayan, A; Bar-Zakai, B; Kuriansky, J; Natour, M; Shabtai, M; Zmora, O, 2004) |
| "5% bupivacaine at 2 mL/h through the ONQ pump is a safe and effective adjunct in postoperative pain management for open inguinal hernia repair." | 9.11 | Evaluation of continuous infusion of 0.5% bupivacaine by elastomeric pump for postoperative pain management after open inguinal hernia repair. ( Bellanger, D; Hausmann, M; LeBlanc, KA; Rhynes, VK, 2005) |
| "To assess the use of infiltration with local anaesthetics levobupivacaine and bupivacaine, during inguinal hernia repair." | 9.10 | Local anaesthesia in elective inguinal hernia repair: a randomised, double-blind study comparing the efficacy of levobupivacaine with racemic bupivacaine. ( Bennett, DH; Cummings, CG; Kingsnorth, AN, 2002) |
| " We conducted a systematic review of randomized controlled trials (RCTs) to evaluate the efficacy of extraperitoneal bupivacaine treatment during laparoscopic inguinal hernia repair for the reduction of postoperative pain." | 8.90 | Effect of extraperitoneal bupivacaine analgesia in laparoscopic inguinal hernia repair: a meta-analysis of randomized controlled trials. ( Bai, CH; Kuo, LJ; Lee, HC; Liang, HH; Tam, KW; Tong, YS; Wei, PL; Wu, CC, 2014) |
| "gov identifier, NCT02525133)], patients undergoing open tension-free mesh inguinal hernia repair were randomized to receive 300-mg bupivacaine (three INL-001 100-mg bupivacaine HCl collagen-matrix implants) (MATRIX-1 n = 204; MATRIX-2 n = 213) or three placebo collagen-matrix implants (MATRIX-1 n = 101; MATRIX-2 n = 106) during surgery." | 7.91 | Safety and Efficacy of Bupivacaine HCl Collagen-Matrix Implant (INL-001) in Open Inguinal Hernia Repair: Results from Two Randomized Controlled Trials. ( Deck, K; Jones, N; Leiman, D; Minkowitz, HS; Niebler, G; Rider, P; Velanovich, V, 2019) |
| " We report a case of prolonged femoral nerve palsy secondary to liposomal bupivacaine use during wound infiltration after inguinal herniorrhaphy." | 7.83 | Inadvertent Prolonged Femoral Nerve Palsy After Field Block with Liposomal Bupivacaine for Inguinal Herniorrhaphy. ( Amundson, A; Kopp, S; Olsen, D, 2016) |
| "We compared retrospectively postoperative analgesia of two concentrations of levobupivacaine by local spraying in radical repair of inguinal hernia." | 7.81 | [Comparison of Postoperative Analgesic Effects between 0.25% Levobupivacaine and 0.5% Levobupivacaine Local Instillation in Inguinal Hernia Repair]. ( Kato, T; Sasaki, H, 2015) |
| "The present study has been designed to compare the postoperative pain relief for inguinal hernia repair in children through wound infiltration with levobupivacaine with that provided by paracetamol administration per rectaly." | 7.77 | Postoperative pain relief following inguinal hernia repair in children by wound infiltration with levobupivacaine. ( Alam, MM; Alam, MN; Ali, MS; Bari, MS; Chowdhury, LH; Haque, N; Hasina, K; Hassanuzzaman, SM; Huq, MA; Khan, N; Mahmud, AA; Talukder, SA; Zahid, MK, 2011) |
| "Patients who presented with an inguinal hernia at a university teaching hospital were evaluated prospectively and randomized to either (1) percutaneous ilioinguinal nerve block or (2) percutaneous ilioinguinal nerve block with additional perineural infiltration of the ilioinguinal, iliohypogastric, genitofemoral nerves." | 6.82 | Perineural bupivacaine injection reduces inguinodynia after inguinal hernia repair. ( Chandler, CF; Crompton, JG; Dawes, AJ; Donald, GW; Livhits, MJ, 2016) |
| "Postoperative pain was scored by means of a 100 mm visual analogue scale." | 6.72 | Combined subfascial and subcutaneous bupivacaine instillation for inguinal hernia wounds. ( Al-Ghazo, MA; Bani-Hani, KE; El-Radaideh, KM, 2006) |
| "Levobupivacaine is a promising new local anaesthetic agent for pain management in paediatric patients and appears to offer similar anaesthetic efficacy to racemic bupivacaine with a potentially improved tolerability profile." | 6.71 | Efficacy and safety of caudal injection of levobupivacaine, 0.25%, in children under 2 years of age undergoing inguinal hernia repair, circumcision or orchidopexy. ( Austin, S; Chalkiadis, GA; Eyres, R; Taylor, R, 2003) |
| "We conclude that for elective inguinal hernia repair, postoperative analgesia obtained by bupivacaine wound infiltration was not improved by the addition of clonidine 150 micrograms." | 6.68 | Does the addition of clonidine affect duration of analgesia of bupivacaine wound infiltration in inguinal hernia surgery? ( Eckersall, S; Elliott, S; Fligelstone, L; Jothilingam, S, 1997) |
| "This study compared the transversus abdominis plane (TAP) block with bupivacaine and dexmedetomidine to the same mixture in the caudal block in delivering postoperative analgesia in children after unilateral inguinal hernia surgery." | 5.69 | Transversus abdominis plane block versus caudal block with bupivacaine and dexmedetomidine for unilateral inguinal hernia repair in pediatric patients: a randomized clinical trial. ( Abdelrady, MM; Abo El Fadl, GM; Anwar, M; Ismael, WA; Osman, HM; Sabra, T, 2023) |
| " The purpose of this study is to compare the efficacy of US-guided TAPB at two different concentrations of bupivacaine in pediatrics undergoing unilateral inguinal hernia repair." | 5.51 | Transversus abdominis plane block with different bupivacaine concentrations in children undergoing unilateral inguinal hernia repair: a single-blind randomized clinical trial. ( Atasever, AG; Bingül, ES; Çiftçi, HŞ; Dinçer, MB; Karadeniz, MS; Salviz, EA; Sungur, MO, 2022) |
| "25% bupivacaine produces more postoperative analgesic effect and less postoperative opioid consumption when compared to posterior QLB approach (QLB-2) in patients underwent unilateral inguinal hernia repair under general anesthesia." | 5.30 | Ultrasound-guided quadratus lumborum block for postoperative pain control in patients undergoing unilateral inguinal hernia repair, a comparative study between two approaches. ( Aboeldahb, H; Ahmed, A; Fahmy, RS; Farid, M; Fawzy, M; Fouad, E; Hussam, AM; Nasr, MAR; Osman, S; Saad, D; Waheb, MM, 2019) |
| "25% levobupivacaine caudally administered on the effect of intra- and postoperative analgesia in children undergoing orchidopexy and inguinal hernia repair." | 5.24 | A Comparison of Three Different Volumes of Levobupivacaine for Caudal Block in Children Undergoing Orchidopexy and Inguinal Hernia Repair. ( Budic, I; Marjanovic, V; Simic, D; Stevic, M, 2017) |
| "The addition of 2μg/kg of dexmedetomidine reduced the minimum local anesthetic concentration of bupivacaine used for a TAP block and improved postoperative analgesia in children undergoing surgery for inguinal hernia repair or hydrocelectomy." | 5.24 | Dexmedetomidine decreases the required amount of bupivacaine for ultrasound-guided transversus abdominis plane block in pediatrics patients: a randomized study. ( Alia, DA; El Metainy, SA; Raof, RA; Wahab, MA, 2017) |
| "To determine the difference in analgesic requirement in terms of mean postoperative narcotic consumption and mean postoperative pain score in patients undergoing unilateral inguinal hernia repair with or without bupivacaine infiltration as day-care patients." | 5.22 | Effects of bupivacaine infiltration on postoperative tramadol consumption in elective day care unilateral inguinal hernia repair. ( Khan, FA; Qureshi, RM, 2016) |
| "The study evaluated the clinical intraoperative effects of intrathecal administration of fentanyl on shoulder tip pain in patients undergoing laparoscopic total extraperitoneal inguinal hernia repair (TEP) under spinal anaesthesia." | 5.17 | Clinical effects of intrathecal fentanyl on shoulder tip pain in laparoscopic total extraperitoneal inguinal hernia repair under spinal anaesthesia: a double-blind, prospective, randomized controlled trial. ( Cho, CK; Kang, PS; Kim, MS; Kim, SH; Kwon, WK; Lee, SE; Park, DH; Sung, TY; Woo, NS, 2013) |
| "In the absence of any study on the use of bupivacaine as a long acting local anesthetic for the purpose of inducing preemptive analgesia in patients undergoing inguinal hernia repair under spinal anesthesia, this study was conducted to provide some evidence for possible benefits of such practice." | 5.17 | The effect of preemptive analgesia with bupivacaine on postoperative pain of inguinal hernia repair under spinal anesthesia: a randomized clinical trial. ( Akhondzadeh, R; Nazaree, E; Nesioonpour, Sh; Pipelzadeh, MR; Rezaee, S; Soleymani, M, 2013) |
| "Caudal bupivacaine is widely used for inguinal hernia repair in children, but often cannot totally eliminate responses to hernial sac traction." | 5.17 | Caudal dexmedetomidine combined with bupivacaine inhibit the response to hernial sac traction in children undergoing inguinal hernia repair. ( Huang, DY; Liu, YX; Luo, T; Wang, GH; Xiang, Q; Zhao, YL; Zhong, L, 2013) |
| "After open inguinal hernia repair, SABER-Bupivacaine administered at the surgical site was safe and provided pain relief, reduced the need for supplemental (oral and parenteral) analgesia and did not impair wound healing." | 5.16 | Safety and efficacy of extended-release bupivacaine local anaesthetic in open hernia repair: a randomized controlled trial. ( Abrouk, N; Fletcher, I; Hadj, A; Lissin, D; Moodie, J; Nicholson, D; Rosenfeldt, F; Turner, R; Watts, R, 2012) |
| "Two hundred and seventy-three patients undergoing day-case open inguinal hernia repair with a mesh were randomly allocated to receive either ultrasound-guided TAP block or blind IHN block with levobupivacaine 0." | 5.15 | Comparison between ultrasound-guided transversus abdominis plane and conventional ilioinguinal/iliohypogastric nerve blocks for day-case open inguinal hernia repair. ( Aveline, C; Bonnet, F; Cognet, F; Le Hetet, H; Le Roux, A; Tison, C; Vautier, P; Vinet, E, 2011) |
| "The present study compared the postoperative analgesic effects of preincisional and postincisional wound infiltration with levobupivacaine and postoperative cortisol and prolactin levels in children following inguinal hernia repair." | 5.14 | Effects of levobupivacaine infiltration on postoperative analgesia and stress response in children following inguinal hernia repair. ( Cevizci, N; Cnar, SO; Kayaoglu, S; Kum, U; Oba, S, 2009) |
| "To compare the postoperative analgesia of three different concentrations of levobupivacaine for ilioinguinal/iliohypogastric (II/IH) block in children undergoing inguinal hernia repair." | 5.14 | Three concentrations of levobupivacaine for ilioinguinal/iliohypogastric nerve block in ambulatory pediatric surgery. ( Astuto, M; Disma, N; Pellegrino, S; Tuo, P, 2009) |
| " However, there was a significant reduction of postoperative pain in the bupivacaine group as well at rest as coughing." | 5.14 | [Efficiency of bupivacaine wound subfasciale infiltration in reduction of postoperative pain after inguinal hernia surgery]. ( Atmani, M; Azendour, H; Belyamani, L; Bensghir, M; Drissi Kamili, N; Elmoqaddem, A; Massou, S; Mounir, K, 2010) |
| "Sixty-three American Society of Anesthesiologists (ASA) I or II children between 1 and 7 years old scheduled for inguinal hernia repair under sevoflurane anesthesia were randomized to receive caudal levobupivacaine 0." | 5.14 | Levobupivacaine-tramadol combination for caudal block in children: a randomized, double-blinded, prospective study. ( Bagus, F; Ozdamar, D; Solak, M; Toker, K; Yildiz, TS, 2010) |
| "kg(-1) added to bupivacaine significantly improves the quality of intraoperative analgesia and prolongs postoperative analgesia in children undergoing inguinal hernia repair with spinal anesthesia." | 5.14 | Effects of intrathecal fentanyl on quality of spinal anesthesia in children undergoing inguinal hernia repair. ( Apiliogullari, S; Duman, A; Duman, I, 2010) |
| "Infiltration of abdominal wounds and extraperitoneal space with bupivacaine in patients undergoing laparoscopic TEP repair of unilateral inguinal hernias does not appear to offer analgesic benefits." | 5.14 | Infiltration of wounds and extraperitoneal space with local anesthetic in patients undergoing laparoscopic totally extraperitoneal repair of unilateral inguinal hernias: a randomized double-blind placebo-controlled trial. ( Abbas, MH; Ammori, BJ; Choudhry, MN; Hamade, A; Hamza, N; Nadeem, R, 2010) |
| "This study compared the effect of single-dose caudal epidural bupivacaine, bupivacaine plus ketamine and bupivacaine plus tramadol for postoperative pain management in children having surgery for inguinal hernia." | 5.13 | Comparison of caudal epidural bupivacaine with bupivacaine plus tramadol and bupivacaine plus ketamine for postoperative analgesia in children. ( Choudhuri, AH; Dharmani, P; Kumarl, N; Prakash, A, 2008) |
| "We conducted a controlled, prospective study of clonidine in caudal anaesthesia in 60 children, aged 1-10 years, undergoing elective inguinal hernia repair." | 5.12 | Clonidine addition prolongs the duration of caudal analgesia. ( Korkmaz, F; Solak, M; Toker, K; Yildiz, TS, 2006) |
| "The aim of the study is to evaluate the efficacy of post-incisional wound infiltration with levobupivacaine in preventing the postoperative pain associated with inguinal hernia repair in children." | 5.12 | Wound infiltration with levobupivacaine: an alternative method of postoperative pain relief after inguinal hernia repair in children. ( Kostopanagiotou, G; Matsota, P; Papageorgiou-Brousta, M, 2007) |
| "We have compared ropivacaine with bupivacaine and lidocaine for ilioinguinal block in thirty children undergoing ambulatory inguinal hernia repair." | 5.11 | Comparison of ropivacaine with bupivacaine and lidocaine for ilioinguinal block after ambulatory inguinal hernia repair in children. ( Ichizawa, M; Shinomura, T; Tsuchiya, N; Yoshikawa, Y, 2004) |
| "Preperitoneal Bupivacaine attenuates pain following laparoscopic inguinal hernia repair and should be considered in these cases." | 5.11 | Preperitoneal bupivacaine attenuates pain following laparoscopic inguinal hernia repair. ( Ayalon, A; Bar-Dayan, A; Bar-Zakai, B; Kuriansky, J; Natour, M; Shabtai, M; Zmora, O, 2004) |
| "In 60 patients undergoing inguinal hernia repair, we compared the clinical profile of unilateral spinal anesthesia produced with either 8 mg of hyperbaric bupivacaine 0." | 5.11 | A prospective, randomized, double-blind comparison of unilateral spinal anesthesia with hyperbaric bupivacaine, ropivacaine, or levobupivacaine for inguinal herniorrhaphy. ( Casati, A; Marchetti, C; Moizo, E; Vinciguerra, F, 2004) |
| "5% bupivacaine at 2 mL/h through the ONQ pump is a safe and effective adjunct in postoperative pain management for open inguinal hernia repair." | 5.11 | Evaluation of continuous infusion of 0.5% bupivacaine by elastomeric pump for postoperative pain management after open inguinal hernia repair. ( Bellanger, D; Hausmann, M; LeBlanc, KA; Rhynes, VK, 2005) |
| "To assess the use of infiltration with local anaesthetics levobupivacaine and bupivacaine, during inguinal hernia repair." | 5.10 | Local anaesthesia in elective inguinal hernia repair: a randomised, double-blind study comparing the efficacy of levobupivacaine with racemic bupivacaine. ( Bennett, DH; Cummings, CG; Kingsnorth, AN, 2002) |
| "In a study of 30 men undergoing elective inguinal hernia repair under general anaesthesia no difference in postoperative pain, patient rating score or morphine consumption was found between patients who had pre-operative ilioinguinal nerve block with bupivacaine 0." | 5.07 | The addition of triamcinolone acetonide to bupivacaine has no effect on the quality of analgesia produced by ilioinguinal nerve block. ( Mackle, E; McCleane, G; Stirling, I, 1994) |
| " We conducted a systematic review of randomized controlled trials (RCTs) to evaluate the efficacy of extraperitoneal bupivacaine treatment during laparoscopic inguinal hernia repair for the reduction of postoperative pain." | 4.90 | Effect of extraperitoneal bupivacaine analgesia in laparoscopic inguinal hernia repair: a meta-analysis of randomized controlled trials. ( Bai, CH; Kuo, LJ; Lee, HC; Liang, HH; Tam, KW; Tong, YS; Wei, PL; Wu, CC, 2014) |
| " We assess the impact of bupivacaine liposome used along with a standard analgesia protocol following robotic inguinal hernia repair." | 4.12 | Bupivacaine liposome use reduces length of post-anesthesia care unit stay and postoperative narcotic use following robotic inguinal herniorrhaphy. ( Afaneh, C; Bellorin, O; Dakin, G; Senturk, J; Vigiola Cruz, M, 2022) |
| "The aim of this article is to investigate the effects of bupivacaine and its S (-)-enantiomer, levobupivacaine, on cardiac arrhythmias in patients." | 4.02 | Comparison Between the Effects of Bupivacaine and Levobupivacaine for Spinal Anesthesia on QT Dispersion. ( Akçay, M; Göğüş, N; İkeda, ÖC; Pehlivan, VF, 2021) |
| "gov identifier, NCT02525133)], patients undergoing open tension-free mesh inguinal hernia repair were randomized to receive 300-mg bupivacaine (three INL-001 100-mg bupivacaine HCl collagen-matrix implants) (MATRIX-1 n = 204; MATRIX-2 n = 213) or three placebo collagen-matrix implants (MATRIX-1 n = 101; MATRIX-2 n = 106) during surgery." | 3.91 | Safety and Efficacy of Bupivacaine HCl Collagen-Matrix Implant (INL-001) in Open Inguinal Hernia Repair: Results from Two Randomized Controlled Trials. ( Deck, K; Jones, N; Leiman, D; Minkowitz, HS; Niebler, G; Rider, P; Velanovich, V, 2019) |
| "Intradural anaesthesia with hyperbaric bupivacaine was the technique most chosen by anaesthesiologists for the management of inguinal hernia surgery." | 3.88 | Survey on the practice of anaesthesiologists in inguinal hernia surgery in Galicia. ( Álvarez Escudero, J; Diéguez García, P; López Álvarez, S; Montero Picallo, AJ; Pensado Castiñeiras, A, 2018) |
| " We report a case of prolonged femoral nerve palsy secondary to liposomal bupivacaine use during wound infiltration after inguinal herniorrhaphy." | 3.83 | Inadvertent Prolonged Femoral Nerve Palsy After Field Block with Liposomal Bupivacaine for Inguinal Herniorrhaphy. ( Amundson, A; Kopp, S; Olsen, D, 2016) |
| "We compared retrospectively postoperative analgesia of two concentrations of levobupivacaine by local spraying in radical repair of inguinal hernia." | 3.81 | [Comparison of Postoperative Analgesic Effects between 0.25% Levobupivacaine and 0.5% Levobupivacaine Local Instillation in Inguinal Hernia Repair]. ( Kato, T; Sasaki, H, 2015) |
| "The data suggest that SA with 1 mg·kg(-1) of either hyperbaric tetracaine or bupivacaine can be used safely as the sole anesthetic for inguinal hernia repair in infants with noncyanotic CHD even when fluid restricted and apparently causes minimal respiratory complications in these infants." | 3.78 | Hemodynamic changes during spinal anesthesia in premature infants with congenital heart disease undergoing inguinal hernia correction. ( Arnon, S; Johnson, VM; Sethna, NF; Shenkman, Z; Zurakowski, D, 2012) |
| "The present study has been designed to compare the postoperative pain relief for inguinal hernia repair in children through wound infiltration with levobupivacaine with that provided by paracetamol administration per rectaly." | 3.77 | Postoperative pain relief following inguinal hernia repair in children by wound infiltration with levobupivacaine. ( Alam, MM; Alam, MN; Ali, MS; Bari, MS; Chowdhury, LH; Haque, N; Hasina, K; Hassanuzzaman, SM; Huq, MA; Khan, N; Mahmud, AA; Talukder, SA; Zahid, MK, 2011) |
| "A 50-year-old man had an inguinal hernia repair under spinal anaesthesia with bupivacaine." | 3.69 | [Delayed low back pain after spinal anesthesia]. ( Abderrazak, M; Boncoeur, MP; Desport, JC; Guillaume, A; Sardin, B, 1995) |
| "5-year-old child with Cornelia de Lange syndrome presenting for orchidopexy and herniotomy received general anaesthesia which was supplemented by a caudal injection of bupivacaine." | 3.67 | Respiratory arrest after a caudal injection of bupivacaine. ( Carli, F; Lumb, AB, 1989) |
| "Postoperative pain was assessed using a visual analog scale (VAS) during postoperative 24 h." | 3.11 | Posterior quadratus lumborum block versus posterior transversus abdominis plane block for unilateral inguinal hernia surgery. ( Akelma, FK; Altinsoy, S; Caparlar, CO; Ergil, J; Ozhan, MO, 2022) |
| "Laparoscopic inguinal hernia repair has facilitated early mobilization." | 2.87 | Laparoscopic-assisted transversus abdominis plane block as an effective analgesic in total extraperitoneal inguinal hernia repair: a double-blind, randomized controlled trial. ( Barry, K; Duggan, M; Khan, A; Khan, IZ; Khan, W; Mughal, A; Naseem, H; Rehman, J; Waldron, R, 2018) |
| "Sixty adult patients undergoing open inguinal hernia repair participated in a single-center, randomized, double-blinded, placebo-controlled trial in a general academic medical center." | 2.84 | Protective multimodal analgesia with etoricoxib and spinal anesthesia in inguinal hernia repair: a randomized controlled trial. ( Ghantous-Toukan, M; Hadjittofi, C; Hawash, N; Matter, I; Somri, M; Tome, R; Yodashkin, M, 2017) |
| " This study evaluated the quality of caudal analgesia achieved with a dosing scheme of 0." | 2.84 | Caudal analgesia for herniotomy: Comparative evaluation of two dose schemes of bupivacaine. ( Akpoduado, DD; Edomwonyi, NP; Imarengiaye, CO, 2017) |
| "BACKGROUND Cardiac arrhythmia is a significant cause of morbidity and mortality." | 2.84 | Effects on QTc Interval of 2 Different Doses of Spinal Anesthesia in Inguinal Hernia Operations. ( Hanbeyoglu, O; Ozcan, S; Urfalioglu, A; Yazar, FM, 2017) |
| "Patients who presented with an inguinal hernia at a university teaching hospital were evaluated prospectively and randomized to either (1) percutaneous ilioinguinal nerve block or (2) percutaneous ilioinguinal nerve block with additional perineural infiltration of the ilioinguinal, iliohypogastric, genitofemoral nerves." | 2.82 | Perineural bupivacaine injection reduces inguinodynia after inguinal hernia repair. ( Chandler, CF; Crompton, JG; Dawes, AJ; Donald, GW; Livhits, MJ, 2016) |
| "Urinary retention was absent." | 2.82 | Randomized comparison of the feasibility of three anesthetic techniques for day-case open inguinal hernia repair. ( Harju, J; Kairaluoma, P; Pere, P; Remes, V; Rosenberg, PH; Turunen, P, 2016) |
| "Levobupivacaine is an enantiomer of racemic bupivacaine with less cardiotoxicity and neurotoxicity." | 2.78 | Local anesthesia for treatment of hernia in elder patients: Levobupicavaine or Bupivacaine? ( Accurso, A; Amato, B; Amato, M; Aprea, G; Bianco, T; Compagna, R; Danzi, M; Fappiano, F; Rossi, R; Vigliotti, G, 2013) |
| "Hypotension is more common with articaine." | 2.77 | Randomised comparison of hyperbaric articaine and hyperbaric low-dose bupivacaine along with fentanyl in spinal anaesthesia for day-case inguinal herniorrhaphy. ( Bachmann, M; Kairaluoma, P; Kallio, H; Pere, P; Rosenberg, PH, 2012) |
| "Levobupivacaine is an enantiomer of racemic bupivacaine with less cardiotoxicity and neurotoxicity." | 2.77 | Comparative study between Levobupivacaine and Bupivacaine for hernia surgery in the elderly. ( Amato, B; Amato, M; Aprea, G; Compagna, R; Coretti, G; Iacono, F; Militello, C; Prezioso, D; Puzziello, A; Vigliotti, G, 2012) |
| "Clonidine has the potential to significantly prolong the duration of caudal epidural anesthesia." | 2.76 | Effect of epidural clonidine on minimum local anesthetic concentration (ED50) of levobupivacaine for caudal block in children. ( Alberighi, OD; Disma, N; Frawley, G; Mameli, L; Montobbio, G; Pistorio, A; Tuo, P, 2011) |
| "Sevoflurane concentration was evaluated after induction and recorded during incision, sac traction and closure." | 2.76 | Single level paravertebral versus caudal block in paediatric inguinal surgery. ( Güneş, Y; Ozcengiz, D; Tug, R, 2011) |
| "Postoperative pain was assessed at 4, 8, 12, 24, 36, and 48 h postoperatively." | 2.75 | A randomized control trial of levobupivacaine, bupivacaine versus placebo extraperitoneal infusion in totally extraperitoneal laparoscopic inguinal hernioplasty. ( Subwongcharoen, S; Udompornmongkol, V, 2010) |
| "Postoperative pain was recorded at 2, 6, and 24 h by an independent assessor using a 0-10 verbal rating scale." | 2.74 | Pre-emptive infiltration of Bupivacaine in laparoscopic total extraperitoneal hernioplasty: a randomized controlled trial. ( Hon, SF; Leong, HT; Poon, CM; Tang, YC, 2009) |
| " Therefore, we performed a prospective, randomized, double-blind study to determine the minimum local analgesic concentrations of a caudal single shot of ropivacaine and levobupivacaine in children and to describe the upper dose-response curve." | 2.74 | Relative analgesic potencies of levobupivacaine and ropivacaine for caudal anesthesia in children. ( Astuto, M; Disma, N; Donath, S; Duffy, C; Frawley, G; Fumagalli, R; Gullo, A; Ingelmo, P; Rosano, G, 2009) |
| "The 40 patients, who had an inguinal hernia with no complication, unilateral or bilateral and recurrence or no recurrence after previous hernia repair, were randomly assigned to receive bupivacaine (n = 19) and normal saline (n = 21)." | 2.74 | A randomized controlled trial of preperitoneal bupivacaine instillation for reducing pain following laparoscopic inguinal herniorrhaphy. ( Noiwan, P; Phansukphon, T; Suvikapakornkul, R; Valaivarangkul, P, 2009) |
| " In phase 2, a further 70 patients were randomly allocated to receive spinal anaesthesia with doses in the upper dose-response range to define the ED95." | 2.74 | Relative potencies of bupivacaine, levobupivacaine, and ropivacaine for neonatal spinal anaesthesia. ( Frawley, G; Ingelmo, P; Smith, KR, 2009) |
| "The presence of postoperative nausea and vomiting (PONV), pruritus and respiratory depression were recorded." | 2.73 | The effect of intravenous administration of dexamethasone on postoperative pain, nausea, and vomiting after intrathecal injection of meperidine. ( Akbarian-Tefaghi, N; Esfehani, F; Movafegh, A; Navi, A; Sadeghi, M; Soroush, AR, 2007) |
| "264 patients scheduled for an inguinal hernia repair using one of three procedures (Lichtenstein, Barwell and TEP = total extraperitoneal hernioplasty) are being randomly allocated intra-operatively into two groups." | 2.73 | Investigating the effect of intra-operative infiltration with local anaesthesia on the development of chronic postoperative pain after inguinal hernia repair. A randomized placebo controlled triple blinded and group sequential study design [NCT00484731]. ( Audigé, L; Fischer, H; Honigmann, P; Kurmann, A; Metzger, J; Schüpfer, G, 2007) |
| "Postoperative pain was assessed at regular intervals for 24 h using All India Institute of Medical Sciences pain score." | 2.72 | Efficacy of three doses of tramadol with bupivacaine for caudal analgesia in paediatric inguinal herniotomy. ( Gogia, AR; Prakash, S; Singh, R; Tyagi, R, 2006) |
| "Postoperative pain was scored by means of a 100 mm visual analogue scale." | 2.72 | Combined subfascial and subcutaneous bupivacaine instillation for inguinal hernia wounds. ( Al-Ghazo, MA; Bani-Hani, KE; El-Radaideh, KM, 2006) |
| "Levobupivacaine is a promising new local anaesthetic agent for pain management in paediatric patients and appears to offer similar anaesthetic efficacy to racemic bupivacaine with a potentially improved tolerability profile." | 2.71 | Efficacy and safety of caudal injection of levobupivacaine, 0.25%, in children under 2 years of age undergoing inguinal hernia repair, circumcision or orchidopexy. ( Austin, S; Chalkiadis, GA; Eyres, R; Taylor, R, 2003) |
| " We randomized 45 patients to 3 groups receiving intrathecal hyperbaric bupivacaine 6 mg combined with saline (Group B), clonidine 15 micro g (Group BC15), or clonidine 30 micro g (Group BC30); all solutions were diluted with saline to 3 mL." | 2.71 | Clonidine combined with small-dose bupivacaine during spinal anesthesia for inguinal herniorrhaphy: a randomized double-blinded study. ( Axelsson, K; Dobrydnjov, I; Gupta, A; Holmström, B; Klockhoff, H; Matthiesen, P; Thörn, SE, 2003) |
| "Haemodynamic, Toddler, Preschooler, Postoperative Pain Scale (TPPPS) pain score and sedation score values were recorded 30 min after extubation and at hours 2, 4, 6, 12 and 24." | 2.71 | Caudal neostigmine for postoperative analgesia in paediatric surgery. ( Karamanlioğlu, B; Kaya, G; Memiş, D; Pamukçu, Z; Süt, N; Turan, A, 2003) |
| "In this study we compare the postoperative pain relief for inguinal herniotomy in children provided by instillation of bupivacaine into the wound with that provided by a caudal block." | 2.71 | Comparison between instillation of bupivacaine versus caudal analgesia for postoperative analgesia following inguinal herniotomy in children. ( Bercker, S; Machotta, A; Pappert, D; Risse, A; Streich, R, 2003) |
| " A dose-response relationship was observed both with regard to median duration of postoperative analgesia (0." | 2.71 | A comparison of three different concentrations of levobupivacaine for caudal block in children. ( Codipietro, L; De Negri, P; Eksborg, S; Grossetti, R; Italiano, S; Ivani, G; Lonnqvist, PA; Mossetti, V; Rosso, F; Tonetti, F, 2003) |
| "Only a relatively short immediate analgesic benefit could be demonstrated by a combination of IINB with spinal anaesthesia compared with IINB combined with general anaesthesia." | 2.71 | Analgesia and discharge following preincisional ilioinguinal and iliohypogastric nerve block combined with general or spinal anaesthesia for inguinal herniorrhaphy. ( Permi, J; Rosenberg, PH; Toivonen, J, 2004) |
| " Both groups were prescribed hydrocodone to use in the postoperative period at the prescribed dosage as needed for pain." | 2.71 | Local anesthetic infusion pumps improve postoperative pain after inguinal hernia repair: a randomized trial. ( Gamberdella, M; Read, B; Sanchez, B; Tatevossian, R; Waxman, K, 2004) |
| "Local infiltration anaesthesia for inguinal hernia repair is cost-effective, but fear of intra-operative pain may hinder its widespread use." | 2.71 | Combined ilioinguinal blockade and local infiltration anaesthesia for groin hernia repair--a double-blind randomized study. ( Andersen, FH; Kehlet, H; Nielsen, K, 2005) |
| "Daily postoperative pain was assessed by visual analogue pain score on a scale from 0 to 10 at rest and upon coughing." | 2.70 | A prospective trial of analgesia following endoscopic totally extraperitoneal (TEP) inguinal hernioplasty. ( Lau, H; Lee, F; Patil, NG; Yuen, WK, 2002) |
| "Postoperative pain was assessed over 5 days using a visual analogue scale." | 2.69 | Randomized placebo-controlled trial of local anaesthetic infusion in day-case inguinal hernia repair. ( Anderson, JR; Fenton-Lee, D; Oakley, MJ; Smith, JS, 1998) |
| "Postoperative pain was assessed 1, 4, 8, 24, and 72 h postoperatively." | 2.69 | Analgesic effect of bupivacaine on extraperitoneal laparoscopic hernia repair. ( Hertz, R; Kuroda, M; Marks, RA; Rozan, JP; Saff, GN, 1998) |
| "Of bupivacaine patients 100% were completely satisfied with the procedure compared with 81% of controls (P = 0." | 2.69 | A randomized controlled trial of extraperitoneal bupivacaine analgesia in laparoscopic hernia repair. ( Horgan, PG; Keane, FB; Kelly, P; O'Riordain, DS; Tanner, WA, 1998) |
| "Time averaged postoperative pain scores (48 h) were 8 (levobupivacaine) and 10 (bupivacaine) in the supine position, 13 (levobupivacaine) and 12 (bupivacaine) while rising from the supine position to sitting, and 9 (levobupivacaine) and 13 (bupivacaine) while walking (VAS; 100 mm = worst pain imaginable) (ns)." | 2.69 | Levobupivacaine vs bupivacaine as infiltration anaesthesia in inguinal herniorrhaphy. ( Andersen, J; Bay-Nielsen, M; Bech, K; Kehlet, H; Klarskov, B, 1999) |
| "125% to 0." | 2.69 | A comparison of two concentrations of bupivacaine and adrenaline with and without fentanyl in paediatric inguinal herniorrhaphy. ( Connelly, NR; Dwyer, M; Joshi, W; Kilaru, PR; Reuben, SS; Schwartz, D, 1999) |
| "Postoperative pain was assessed with mCHEOPS in the anaesthesia recovery room, with postoperative usage of opioid and acetaminophen in the hospital, and with parental assessment of pain with a VAS." | 2.68 | Regional anaesthesia for hernia repair in children: local vs caudal anaesthesia. ( Bass, J; Komocar, L; Splinter, WM, 1995) |
| "We conclude that for elective inguinal hernia repair, postoperative analgesia obtained by bupivacaine wound infiltration was not improved by the addition of clonidine 150 micrograms." | 2.68 | Does the addition of clonidine affect duration of analgesia of bupivacaine wound infiltration in inguinal hernia surgery? ( Eckersall, S; Elliott, S; Fligelstone, L; Jothilingam, S, 1997) |
| "Postoperative pain was assessed by ward nurses who were blinded to the group allocation." | 2.67 | Postoperative pain relief in children. A comparison between caudal bupivacaine and intramuscular diclofenac sodium. ( Adamski, J; Leppäluoto, J; Puhakka, K; Ryhänen, J; Ryhänen, P; Vuolteenaho, O, 1994) |
| "In Germany approximately 150,000 inguinal hernias are surgically corrected every year." | 2.67 | [A concept for decreasing postoperative pain after inguinal hernia operation]. ( Isemer, FE; Röder, W; Weigel, TF, 1994) |
| "Bupivacaine instillation was found to be simple, safe and effective." | 2.67 | A comparison of bupivacaine instillation and inguinal field block for control of pain after herniorrhaphy. ( Hunter, SJ; Spittal, MJ, 1992) |
| "Sixty children undergoing inguinal hernia repair under general anesthesia were randomized to receive 0." | 2.67 | A comparison between bupivacaine instillation versus ilioinguinal/iliohypogastric nerve block for postoperative analgesia following inguinal herniorrhaphy in children. ( Broadman, L; Casey, WF; Guzzetta, P; Hannallah, RS; Norden, JM; Rice, LJ, 1990) |
| "01); total codeine dosage was lower in group 1 (4." | 2.66 | Intraoperative bupivacaine during outpatient hernia repair in children: a randomized double blind trial. ( Langer, JC; Rosenberg, M; Shandling, B, 1987) |
| "Simple oral analgesics are adequate for postoperative pain relief in 87." | 2.65 | Evaluation of dextran with local anaesthesia for short-stay inguinal herniorraphy. ( Grixti, CJ; Kingsnorth, AN; Wijesinha, SS, 1979) |
| "Open inguinal hernia repair is one of the most painful procedures in day surgery." | 2.50 | Local anesthetic infusion pump for pain management following open inguinal hernia repair: a meta-analysis. ( Bai, CH; Huang, MT; Tam, KW; Wu, CC; Wu, CH, 2014) |
| "Postoperative pain was compared in the recovery room and outpatient suite." | 2.41 | Extraperitoneal laparoscopic hernia repair with local anesthesia. ( Edelman, DS; Misiakos, EP; Moses, K, 2001) |
| "5% (5 mg/ml) was used for and dosage was calculated based on the patient's weight with no more than 2 mg/kg." | 1.72 | Surgeon-administered ilio-inguinal and pudendal nerve blocks for major vulval surgery: An observational study with visual analogue pain scoring. ( Gleeson, N; Maguire, PJ; Shahabuddin, Y, 2022) |
| " The most common adverse events (AEs) in both groups were associated with general anesthesia and the postsurgical setting." | 1.62 | Pharmacokinetics and Safety of INL-001 (Bupivacaine HCl) Implants Compared with Bupivacaine HCl Infiltration After Open Unilateral Inguinal Hernioplasty. ( Leiman, D; Minkowitz, HS; Niebler, G, 2021) |
| "Neonates with inguinal hernia face a relatively high risk of incarcerated hernia and bowel obstruction and this therefore requires surgical treatment." | 1.37 | Awake caudal anesthesia for inguinal hernia operations: successful use in low birth weight neonates. ( Cekic, B; Geze, S; Imamoğlu, M, 2011) |
| "There was no adverse effect in either species." | 1.37 | The safety and tolerability evaluation of DepoFoam bupivacaine (bupivacaine extended-release liposome injection) administered by incision wound infiltration in rabbits and dogs. ( Brubaker, AN; Cole, PI; Haan, D; Nelson, KG; Newton, PE; Ott, LR; Rebelatto, MC; Richard, BM; Ross, PE, 2011) |
| "Local anesthetic inguinal hernia repair in the obese is safe and well tolerated." | 1.35 | Local anesthetic hernia repair in overweight and obese patients. ( Reid, TD; Sanjay, P; Woodward, A, 2009) |
| "Local anaesthetic inguinal hernia repair may be technically demanding." | 1.35 | Local anaesthetic inguinal hernia repair performed under supervision: early and long-term outcomes. ( Sanjay, P; Woodward, A, 2009) |
| "Incarcerated inguinal hernias in infants are commonly encountered." | 1.33 | Reduction of incarcerated inguinal hernia in infants using caudal epidural anaesthesia. ( Brindley, N; Brown, S; Taylor, R, 2005) |
| "Choice of anesthesia for inguinal hernia repair remains a controversial topic." | 1.32 | Paravertebral block anesthesia for inguinal hernia repair. ( Arbo, JE; Greengrass, RA; Klein, SM; Weltz, CR, 2003) |
| "Twelve FPI scheduled for inguinal hernia repair were operated under spinal anesthesia using 1 mg/kg isobaric 0." | 1.32 | Spinal anesthesia with bupivacaine decreases cerebral blood flow in former preterm infants. ( Asehnoune, K; Benhamou, D; Bonnet, MP; Larousse, E, 2004) |
| "Awake regional anaesthesia for inguinal hernia repair in former preterm infants is suggested to avoid life-threatening respiratory complications known to occur after general anaesthesia." | 1.31 | Apnoea in a former preterm infant after caudal bupivacaine with clonidine for inguinal herniorrhaphy. ( Fellmann, C; Gerber, AC; Weiss, M, 2002) |
| "We conclude that open inguinal hernia repair can be conducted under ULA, regardless of comorbidity, with a small rate of deviation from day-case setup and minimal morbidity." | 1.31 | One-thousand consecutive inguinal hernia repairs under unmonitored local anesthesia. ( Bech, K; Callesen, T; Kehlet, H, 2001) |
| "Intraoperative pain is the main topic that requires improvement." | 1.31 | Feasibility of local infiltration anaesthesia for recurrent groin hernia repair. ( Bech, K; Callesen, T; Kehlet, H, 2001) |
| "Bupivacaine was found to be superior to lidocaine in decreasing the need for postoperative narcotic analgesia." | 1.30 | The effects of local anesthetics on postoperative pain. ( McEwen, M; Roberge, CW, 1998) |
| "There were 4 recurrences due to technical errors which are described." | 1.29 | [Lichtenstein's "tension-free" operation for inguinal hernia under local anesthesia]. ( Amid, PK; Bocchi, P; Lichtenstein, IL; Shulman, AG, 1995) |
| "Per- and postoperative pain treatment were pre- and postoperative oral tenoxicam and methadone plus infiltration of the surgical field with up to 60 ml of 0." | 1.29 | [Pain and convalescence after ambulatory inguinal herniotomy during local anesthesia]. ( Bardram, L; Hesselfeldt, P; Kehlet, H; Møiniche, S, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 31 (12.50) | 18.7374 |
| 1990's | 62 (25.00) | 18.2507 |
| 2000's | 85 (34.27) | 29.6817 |
| 2010's | 59 (23.79) | 24.3611 |
| 2020's | 11 (4.44) | 2.80 |
| Authors | Studies |
|---|---|
| Vigiola Cruz, M | 1 |
| Senturk, J | 1 |
| Dakin, G | 1 |
| Afaneh, C | 1 |
| Bellorin, O | 1 |
| Shahabuddin, Y | 1 |
| Gleeson, N | 1 |
| Maguire, PJ | 1 |
| Caparlar, CO | 1 |
| Altinsoy, S | 1 |
| Akelma, FK | 1 |
| Ozhan, MO | 1 |
| Ergil, J | 1 |
| Karadeniz, MS | 3 |
| Atasever, AG | 3 |
| Salviz, EA | 3 |
| Bingül, ES | 3 |
| Çiftçi, HŞ | 3 |
| Dinçer, MB | 3 |
| Sungur, MO | 3 |
| Abo El Fadl, GM | 1 |
| Osman, HM | 1 |
| Anwar, M | 1 |
| Sabra, T | 1 |
| Ismael, WA | 1 |
| Abdelrady, MM | 1 |
| Viscusi, E | 1 |
| Minkowitz, H | 1 |
| Winkle, P | 2 |
| Ramamoorthy, S | 1 |
| Hu, J | 2 |
| Singla, N | 2 |
| Ahmed, A | 1 |
| Fawzy, M | 1 |
| Nasr, MAR | 1 |
| Hussam, AM | 1 |
| Fouad, E | 1 |
| Aboeldahb, H | 1 |
| Saad, D | 1 |
| Osman, S | 1 |
| Fahmy, RS | 1 |
| Farid, M | 1 |
| Waheb, MM | 1 |
| Samerchua, A | 1 |
| Leurcharusmee, P | 1 |
| Panichpichate, K | 1 |
| Bunchungmongkol, N | 1 |
| Wanvoharn, M | 1 |
| Tepmalai, K | 1 |
| Khorana, J | 1 |
| Chantakhow, S | 1 |
| Bertoch, T | 1 |
| Beaton, A | 1 |
| Redan, J | 1 |
| Oham, A | 1 |
| Ekwere, I | 1 |
| Tobi, K | 1 |
| Leiman, D | 2 |
| Niebler, G | 2 |
| Minkowitz, HS | 2 |
| Samy, AM | 1 |
| Anandhi, A | 1 |
| Sreenath, GS | 1 |
| Sureshkumar, S | 1 |
| Swaminathan, S | 1 |
| Pehlivan, VF | 1 |
| Akçay, M | 1 |
| İkeda, ÖC | 1 |
| Göğüş, N | 1 |
| Marjanovic, V | 1 |
| Budic, I | 1 |
| Stevic, M | 1 |
| Simic, D | 1 |
| Somri, M | 3 |
| Hawash, N | 1 |
| Hadjittofi, C | 1 |
| Ghantous-Toukan, M | 1 |
| Tome, R | 1 |
| Yodashkin, M | 1 |
| Matter, I | 1 |
| Cybułka, B | 1 |
| Kulasegaran, S | 1 |
| Rohan, M | 1 |
| Pearless, L | 1 |
| Hulme-Moir, M | 1 |
| Bhatia, N | 1 |
| Sen, IM | 1 |
| Mandal, B | 1 |
| Batra, A | 1 |
| López Álvarez, S | 1 |
| Montero Picallo, AJ | 1 |
| Diéguez García, P | 1 |
| Pensado Castiñeiras, A | 1 |
| Álvarez Escudero, J | 1 |
| Mughal, A | 1 |
| Khan, A | 1 |
| Rehman, J | 1 |
| Naseem, H | 1 |
| Waldron, R | 1 |
| Duggan, M | 1 |
| Khan, W | 1 |
| Barry, K | 1 |
| Khan, IZ | 1 |
| Velanovich, V | 1 |
| Rider, P | 1 |
| Deck, K | 1 |
| Jones, N | 1 |
| Tong, YS | 1 |
| Wu, CC | 2 |
| Bai, CH | 2 |
| Lee, HC | 1 |
| Liang, HH | 1 |
| Kuo, LJ | 1 |
| Wei, PL | 1 |
| Tam, KW | 2 |
| Sung, TY | 1 |
| Kim, MS | 1 |
| Cho, CK | 1 |
| Park, DH | 1 |
| Kang, PS | 1 |
| Lee, SE | 1 |
| Kwon, WK | 1 |
| Woo, NS | 1 |
| Kim, SH | 1 |
| Gürkan, I | 1 |
| Utebey, G | 1 |
| Özlü, O | 1 |
| Compagna, R | 2 |
| Vigliotti, G | 2 |
| Bianco, T | 1 |
| Amato, M | 2 |
| Rossi, R | 1 |
| Fappiano, F | 1 |
| Accurso, A | 1 |
| Danzi, M | 1 |
| Aprea, G | 2 |
| Amato, B | 2 |
| Huang, MT | 1 |
| Wu, CH | 1 |
| Erdoğan Arı, D | 1 |
| Yıldırım Ar, A | 1 |
| Karadoğan, F | 1 |
| Özcabı, Y | 1 |
| Koçoğlu, A | 1 |
| Kılıç, F | 1 |
| Akgün, FN | 1 |
| Kato, T | 1 |
| Sasaki, H | 1 |
| Tomak, Y | 1 |
| Erdivanli, B | 1 |
| Sen, A | 1 |
| Bostan, H | 1 |
| Budak, ET | 1 |
| Pergel, A | 1 |
| Fusco, P | 1 |
| Cofini, V | 1 |
| Petrucci, E | 1 |
| Scimia, P | 1 |
| Paladini, G | 1 |
| Behr, AU | 1 |
| Gobbi, F | 1 |
| Pozone, T | 1 |
| Danelli, G | 1 |
| Di Marco, M | 1 |
| Vicentini, R | 1 |
| Necozione, S | 1 |
| Marinangeli, F | 1 |
| Qureshi, RM | 1 |
| Khan, FA | 2 |
| Olsen, D | 1 |
| Amundson, A | 1 |
| Kopp, S | 1 |
| Wijayasinghe, N | 1 |
| Ringsted, TK | 1 |
| Bischoff, JM | 1 |
| Kehlet, H | 8 |
| Werner, MU | 1 |
| Crompton, JG | 1 |
| Dawes, AJ | 1 |
| Donald, GW | 1 |
| Livhits, MJ | 1 |
| Chandler, CF | 1 |
| Pere, P | 3 |
| Harju, J | 1 |
| Kairaluoma, P | 3 |
| Remes, V | 1 |
| Turunen, P | 1 |
| Rosenberg, PH | 4 |
| Eppstein, AC | 1 |
| Sakamoto, B | 1 |
| Akpoduado, DD | 1 |
| Imarengiaye, CO | 1 |
| Edomwonyi, NP | 1 |
| Raof, RA | 1 |
| El Metainy, SA | 1 |
| Alia, DA | 1 |
| Wahab, MA | 1 |
| Hanbeyoglu, O | 1 |
| Urfalioglu, A | 1 |
| Yazar, FM | 1 |
| Ozcan, S | 1 |
| Hon, SF | 1 |
| Poon, CM | 1 |
| Leong, HT | 1 |
| Tang, YC | 1 |
| Reid, TD | 1 |
| Sanjay, P | 2 |
| Woodward, A | 2 |
| Saadawy, I | 1 |
| Boker, A | 1 |
| Elshahawy, MA | 1 |
| Almazrooa, A | 1 |
| Melibary, S | 1 |
| Abdellatif, AA | 1 |
| Afifi, W | 1 |
| Yao, YS | 1 |
| Qian, B | 1 |
| Chen, BZ | 1 |
| Wang, R | 1 |
| Tan, L | 1 |
| Ingelmo, P | 2 |
| Frawley, G | 3 |
| Astuto, M | 3 |
| Duffy, C | 1 |
| Donath, S | 1 |
| Disma, N | 4 |
| Rosano, G | 1 |
| Fumagalli, R | 1 |
| Gullo, A | 1 |
| Cnar, SO | 1 |
| Kum, U | 1 |
| Cevizci, N | 1 |
| Kayaoglu, S | 1 |
| Oba, S | 1 |
| Subwongcharoen, S | 1 |
| Udompornmongkol, V | 1 |
| Suvikapakornkul, R | 1 |
| Valaivarangkul, P | 1 |
| Noiwan, P | 1 |
| Phansukphon, T | 1 |
| Kulacoglu, H | 2 |
| Ozyaylali, I | 2 |
| Yazicioglu, D | 2 |
| Narita, M | 1 |
| Sakano, S | 1 |
| Okamoto, S | 1 |
| Uemoto, S | 1 |
| Yamamoto, M | 1 |
| Kumar, S | 1 |
| Joshi, M | 1 |
| Chaudhary, S | 1 |
| Smith, KR | 1 |
| Tuo, P | 2 |
| Pellegrino, S | 1 |
| Bhattacharya, P | 1 |
| Mandal, MC | 1 |
| Mukhopadhyay, S | 1 |
| Das, S | 1 |
| Pal, PP | 1 |
| Basu, SR | 1 |
| Pala, Y | 2 |
| Ozcan, M | 2 |
| Dikmeer, G | 1 |
| Taspinar, V | 2 |
| Ornek, D | 1 |
| Ozdogan, L | 1 |
| Selcuk, A | 2 |
| Dikmen, B | 2 |
| Russ, AJ | 1 |
| Faucher, LD | 1 |
| Gordon, DB | 2 |
| Pellino, TA | 2 |
| Schurr, MJ | 2 |
| Mounir, K | 1 |
| Bensghir, M | 1 |
| Elmoqaddem, A | 1 |
| Massou, S | 1 |
| Belyamani, L | 1 |
| Atmani, M | 1 |
| Azendour, H | 1 |
| Drissi Kamili, N | 1 |
| Yildiz, TS | 2 |
| Ozdamar, D | 1 |
| Bagus, F | 1 |
| Solak, M | 2 |
| Toker, K | 2 |
| Duman, A | 1 |
| Apiliogullari, S | 1 |
| Duman, I | 1 |
| Abbas, MH | 1 |
| Hamade, A | 1 |
| Choudhry, MN | 1 |
| Hamza, N | 1 |
| Nadeem, R | 1 |
| Ammori, BJ | 1 |
| Taheri, R | 1 |
| Shayeghi, S | 1 |
| Razavi, SS | 1 |
| Sadeghi, A | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Quadratus Lumborum Block for Postoperative Pain Control in Patients Undergoing Unilateral Inguinal Hernia Repair, a Comparative Study Between Two Approaches[NCT03526731] | 40 participants (Actual) | Interventional | 2018-06-01 | Completed | |||
| Comparison of The Postoperative Analgesic Effectiveness of Ultrasound-Guided Quadratus Lumborum Block and Ilioinguinal Iliohypogastric Nerve Block in Pediatric Inguinal Hernia Operation, Prospective Randomized Controlled Study[NCT05610943] | 60 participants (Actual) | Interventional | 2022-11-01 | Completed | |||
| A Randomized, Single Blind Study to Investigate the PK, Relative Bioavailability and Safety of INL-001 Bupivacaine HCl Collagen-Matrix Implant 300 mg Compared to Marcaine™ 0.25% (Bupivacaine HCl) 175 mg Infiltration After Open Hernioplasty[NCT03234374] | Phase 1 | 52 participants (Actual) | Interventional | 2017-06-02 | Completed | ||
| Pre-incision Versus Lapaorscopic-assisted Transversus Abdominis Plane (TAP) and Rectus Sheath Block for Post-Cholecystectomy Pain Management: A Randomized Controlled Trial[NCT05856682] | 224 participants (Anticipated) | Interventional | 2022-07-01 | Enrolling by invitation | |||
| A Phase 3, Randomized, Double-blind, Placebo-controlled Study to Investigate the Efficacy and Safety of the XaraColl® Bupivacaine Implant (300 mg Bupivacaine Hydrochloride) After Open Laparotomy Hernioplasty[NCT02525133] | Phase 3 | 319 participants (Actual) | Interventional | 2015-09-05 | Completed | ||
| A Phase 3, Randomized, Double-blind, Placebo-controlled Study to Investigate the Efficacy and Safety of the XaraColl® Bupivacaine Implant (300 mg Bupivacaine Hydrochloride) After Open Laparotomy Hernioplasty[NCT02523599] | Phase 3 | 305 participants (Actual) | Interventional | 2015-08-31 | Completed | ||
| Trigger-point Blockade in Persistent Pain After Open Groin Hernia Repair[NCT02065219] | Phase 3 | 20 participants (Actual) | Interventional | 2013-11-30 | Completed | ||
| The Significance of Peripheral Input in Patients With Post Surgery Neuropathic Pain: Evaluation of Trigger Point Anesthesia. A Double-blind, Randomized, Controlled Exploratory Study[NCT04764045] | 12 participants (Anticipated) | Interventional | 2019-11-20 | Recruiting | |||
| Efficacy of Adding Dexmedetomidine Versus Ibuprofen as an Adjuvant to Intraperitoneal Bupivacaine for Pain Control After Laparoscopic Gynecological Procedures: a Double-blind Randomized Comparative Study[NCT06046105] | Phase 2/Phase 3 | 180 participants (Anticipated) | Interventional | 2023-09-15 | Not yet recruiting | ||
| Comparison of Caudal Bupivacaine Alone With Bupivacaine Plus Two Doses of Dexmedetomidine for Postoperative Analgesia in Pediatric Patients Undergoing Infra-umbilical Surgery: A Randomized Controlled Double Blinded Study[NCT02385435] | Phase 2/Phase 3 | 91 participants (Actual) | Interventional | 2014-01-31 | Completed | ||
| Addition of Magnesium Sulfate to Caudal for Prevention of Emergence Agitation in Children[NCT02164773] | Phase 4 | 70 participants (Anticipated) | Interventional | 2013-10-31 | Recruiting | ||
| "Comparison of Analgesic Effects of USG-Guided Caudal Versus Ilioinguinal/Iliohypogastric Nerve Block Techniques for Inguinal Surgeries in Children, a Randomized Controlled Trial."[NCT05558748] | 128 participants (Anticipated) | Interventional | 2022-12-06 | Recruiting | |||
| The Assessment of Bupivacaine-tramadol and Levobupivacaine-tramadol Combinations for Preemptive Caudal Anaesthesia in Children: a Randomized, Double-blind, Prospective Study[NCT01974843] | 68 participants (Actual) | Observational [Patient Registry] | 2011-01-31 | Completed | |||
| Fentanyl Versus Midazolam as an Adjunct to Intrathecal Bupivacaine for Postoperative Analgesia in Children Undergoing Infraumbilical Surgery[NCT03592537] | Phase 2/Phase 3 | 90 participants (Actual) | Interventional | 2018-08-15 | Completed | ||
| Effect of Medial vs Traditional Approach to US-guided Transverse Abdominis Plane (TAP) Blocks on Analgesia After Open Inguinal Hernia Repair[NCT01589796] | 100 participants (Anticipated) | Interventional | 2012-04-30 | Recruiting | |||
| Comparison of the Effects of Perioperative Anesthesia Consumption of Ultrasound Guided Subcostal Transversus Abdominis Plane and Paravertebral Block in Laparoscopic Cholecystectomy[NCT02379780] | 50 participants (Actual) | Interventional | 2014-09-30 | Completed | |||
| Randomized Prospective Comparison of Analgesic Efficacy of Surgeon Performed IIlioinguinal/Iliohypogastric Blockade With Ultrasound-Guided TAP Blockade in Pediatric Patients Undergoing Unilateral Herniorrhaphy on an Outpatient Basis[NCT01740193] | 59 participants (Actual) | Interventional | 2012-08-31 | Completed | |||
| Comparison of Two Different Spinal Anesthesia Techniques in Outpatient Anorectal Surgery[NCT05409820] | 68 participants (Anticipated) | Observational | 2022-06-15 | Not yet recruiting | |||
| Liposomal Bupivacaine in Implant Based Breast Reconstruction[NCT02659501] | 24 participants (Actual) | Interventional | 2015-07-31 | Terminated | |||
| Prospective Randomized Trial of Penile Nerve Block With Liposomal Bupivacaine for Hypospadias Repair vs Standard Penile Block With Bupivacaine[NCT04479371] | Phase 1 | 0 participants (Actual) | Interventional | 2021-07-31 | Withdrawn (stopped due to Limited funding and resources to complete FDA requirements for enrollment) | ||
| A Double-Blind, Multi-Center, Placebo-Controlled Trial of SABER-Bupivacaine for Post-Operative Pain Control and Opioid Sparing/Opioid-Related Adverse Event Reduction Following Arthroscopic Shoulder Surgery[NCT00818363] | Phase 2 | 60 participants (Actual) | Interventional | 2008-12-31 | Completed | ||
| A Double-Blind, Placebo-Controlled, Pharmacodynamic and Pharmacokinetic Dose Response Study of SABER-Bupivacaine Instilled Into the Wound in Patients Undergoing Open Inguinal Hernia Repair[NCT00974350] | Phase 2 | 124 participants (Actual) | Interventional | 2007-01-31 | Completed | ||
| Hypotension in Spinal Anesthesia for Total Knee Joint Arthroplasty: a Comparison of Taylor's Approach With Paramedian Lumbar Approach[NCT02302378] | 30 participants (Actual) | Interventional | 2015-01-31 | Completed | |||
| Addition of Dexmedetomidine to Levobupivacaine for Transversus Abdominis Plane Block in Elderly Patients Undergoing Inguinal Hernia Repair Surgery: Could it Make a Difference?[NCT04971759] | Phase 2/Phase 3 | 90 participants (Actual) | Interventional | 2019-12-01 | Completed | ||
| The Analgesic Efficacy of the Ultrasound Guided Transversus Abdominis Plane Block After Inguinal Hernia Repair With a Mesh.[NCT02030223] | 59 participants (Actual) | Interventional | 2014-01-31 | Completed | |||
| Effects Of Adjuvants (Dexamethasone and Dexmedetomidine) to Caudal Anesthesia on Cardiac Output and Hemodynamics Measured By Electrical Cardiometry In Children: A Randomized Double Blind Study[NCT03101137] | Phase 4 | 48 participants (Actual) | Interventional | 2016-02-29 | Completed | ||
| Analgesic and Hemodynamic Effects of Continuous Epidural Analgesia Compared to Paravertebral Block in Liver Resection Patients[NCT02909322] | Phase 4 | 50 participants (Anticipated) | Interventional | 2016-04-30 | Recruiting | ||
| Ultrasound Guided Caudal Block Versus Quadratus Lumborum Block for Inguinal Hernioraphy in Preschool Children.[NCT03811392] | 60 participants (Actual) | Interventional | 2019-10-01 | Completed | |||
| Neonatal Spinal Anesthesia: Effects of the Addition of Clonidine[NCT01075490] | Phase 4 | 120 participants (Anticipated) | Interventional | 2006-11-30 | Recruiting | ||
| Ilioinguinal/Iliohypogastric vs. Quadratus Lumborum Nerve Blockade for Elective Open Inguinal Herniorrhaphy[NCT03007966] | Phase 2 | 60 participants (Actual) | Interventional | 2017-01-30 | Completed | ||
| A Comparison of Tumescence in Breast Reduction Surgery[NCT01602692] | Phase 4 | 40 participants (Actual) | Interventional | 2012-08-31 | Completed | ||
| The Short and Long-term Effects of Ultrasound-guided Ilioinguinal and Iliohypogastric Nerve Block on Postoperative Pain Control Following Open Inguinal Hernia Repair[NCT01871181] | 20 participants (Actual) | Interventional | 2013-05-31 | Terminated (stopped due to PI no longer at institution) | |||
| A Comparison Of Ultrasound and Predetermined Distance Techniques For Paravertebral Space Localization In Breast Surgery: A Randomized Prospective Trial[NCT01217593] | 60 participants (Anticipated) | Interventional | 2010-10-31 | Recruiting | |||
| Study of Analgesic Efficacy of Different Kinds of Nerve Blocks on Otoplastic Surgery[NCT04192708] | Phase 4 | 144 participants (Anticipated) | Interventional | 2020-02-17 | Recruiting | ||
| A New Approach to Ilio-inguinal Nerve Blocks: 3-layer Injection vs Conventional Ultrasound-guided Single-shot Approach[NCT01625780] | 32 participants (Actual) | Interventional | 2012-04-30 | Terminated (stopped due to Not a significant difference in outcomes between groups) | |||
| ROPIVACAINE WITH CLONIDINE FOR PEDIATRIC RECTUS SHEATH BLOCKS- THE MAGIC COMBINATION? - A Double Blinded Prospective Study[NCT02439281] | 50 participants (Actual) | Interventional | 2015-05-31 | Terminated (stopped due to The patients were discharged on the day of the surgery.) | |||
| Evaluation of the Analgesic Effect of Tramadol Wound Infiltration in Children Under Inguinal Hernioplasty. A Double-blind, Randomized Study.[NCT01943760] | Phase 4 | 40 participants (Actual) | Interventional | 2012-09-30 | Completed | ||
| Randomized Double Blind Clinical Trial on the Effect of Levobupivacaine Infiltration Versus Placebo on the Post Partum Perineal Pain in Episiotomy in Primiparous Women After Instrumental Delivery[NCT02796547] | Phase 2 | 0 participants (Actual) | Interventional | 2016-07-14 | Withdrawn (stopped due to Lack of human ressources) | ||
| Effect of Intravenous Paracetamol in Combination With Caudal Ropivacaine on Quality of Postoperative Recovery in Paediatric Patients Undergoing Hypospadias Repair[NCT03781505] | Phase 4 | 64 participants (Anticipated) | Interventional | 2019-01-31 | Recruiting | ||
| Intraoperative Wound Instillation of Levobupivacaine is Effective in Postoperative Pain Management for Hernia Repair in Children: a Randomized Controlled Clinical Trial[NCT04869046] | Phase 4 | 100 participants (Actual) | Interventional | 2013-03-31 | Completed | ||
| Investigating the Effect of Intra-operative Infiltration With Local Anaesthesia on the Development of Chronic Postoperative Pain After Inguinal Hernia Repair. A Randomized Placebo Controlled Triple Blinded and Group Sequential Study Design[NCT00484731] | 404 participants (Actual) | Interventional | 2006-07-31 | Completed | |||
| A Comparison of Ultrasound-assisted Paravertebral Block and General Anesthesia for Outpatient Breast Cancer Surgery, a Prospective Randomized Trial[NCT00645138] | Phase 3 | 40 participants (Anticipated) | Interventional | 2008-04-30 | Completed | ||
| Comparison Of Ultrasound-Assisted Paravertebral Block And Traditional Paravertebral Block For Pain Control After Thoracic Surgery, A Prospective Randomized Trial[NCT01949480] | 45 participants (Actual) | Interventional | 2013-07-01 | Completed | |||
| The Effects of Single-dose Rectal Midazolam Application on Post-operative Recovery, Sedation, and Analgesia in Children Given Caudal Anesthesia Plus Bupivacaine[NCT02127489] | Phase 4 | 40 participants (Actual) | Interventional | 2005-06-30 | Completed | ||
| A Comparison of the Effect of Intravenous Sedation Versus General Anesthesia in Patients Undergoing Minor Gynecologic Surgery[NCT01890707] | 19 participants (Actual) | Interventional | 2012-10-19 | Terminated (stopped due to Change in procedure.) | |||
| Ultrasonography Guided Ilioinguinal /Iliohypogastric Block Versus Transversus Abdominis Plane Block in Intraoperative Anesthesia in Children - Randomized Controlled Study[NCT02991053] | 100 participants (Anticipated) | Interventional | 2016-12-31 | Active, not recruiting | |||
| The Effect of Local Wound Infiltration Versus Caudal Block on Wound Infection and Healing After Inguinal Herniotomy Paediatrics[NCT03563625] | 50 participants (Actual) | Interventional | 2017-11-04 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Area under the plasma concentration-time curve from Time 0 to last time of last quantifiable plasma concentration (AUC0-last) (NCT03234374)
Timeframe: 0.5, 1, 1.5, 2, 3, 4, 5, 6, 9, 12, 18, 24, 36, 48 and 72 hours
| Intervention | h*ng/[mL*mg] (Geometric Mean) |
|---|---|
| INL-001 | 18,186.9 |
| Marcaine 0.25% Infiltration | 8836.9 |
AUC = area under the plasma concentration-time curve; (NCT03234374)
Timeframe: 0.5, 1, 1.5, 2, 3, 4, 5, 6, 9, 12, 18, 24, 36, 48 and 72 hours
| Intervention | (h*ng/mL) (Geometric Mean) |
|---|---|
| INL-001 | 2.96 |
| Marcaine 0.25% Infiltration | 0.65 |
AUC from Time 0 to infinity (NCT03234374)
Timeframe: 0.5, 1, 1.5, 2, 3, 4, 5, 6, 9, 12, 18, 24, 36, 48 and 72 hours
| Intervention | h*ng/[mL*mg] (Geometric Mean) |
|---|---|
| INL-001 | 19,012.5 |
| Marcaine 0.25% Infiltration | 8920.1 |
Maximum (peak) plasma concentration (NCT03234374)
Timeframe: 0.5, 1, 1.5, 2, 3, 4, 5, 6, 9, 12, 18, 24, 36, 48 and 72 hours.
| Intervention | ng/ml (Mean) |
|---|---|
| INL-001 | 663.412 |
| Marcaine 0.25% Infiltration | 641.000 |
Terminal half-life (NCT03234374)
Timeframe: 0.5, 1, 1.5, 2, 3, 4, 5, 6, 9, 12, 18, 24, 36, 48 and 72 hours
| Intervention | hours (Mean) |
|---|---|
| INL-001 | 0.04 |
| Marcaine 0.25% Infiltration | 0.09 |
Lag-time (NCT03234374)
Timeframe: 0.5, 1, 1.5, 2, 3, 4, 5, 6, 9, 12, 18, 24, 36, 48 and 72 hours
| Intervention | hours (Mean) |
|---|---|
| INL-001 | 0.51 |
| Marcaine 0.25% Infiltration | 0.47 |
Time to maximum (peak) plasma concentration (NCT03234374)
Timeframe: 0.5, 1, 1.5, 2, 3, 4, 5, 6, 9, 12, 18, 24, 36, 48 and 72 hours
| Intervention | hours (Median) |
|---|---|
| INL-001 | 3.03 |
| Marcaine 0.25% Infiltration | 1.01 |
Terminal phase rate constant (NCT03234374)
Timeframe: 0.5, 1, 1.5, 2, 3, 4, 5, 6, 9, 12, 18, 24, 36, 48 and 72 hours
| Intervention | 1/hour (Mean) |
|---|---|
| INL-001 | 18.95 |
| Marcaine 0.25% Infiltration | 9.08 |
"The primary efficacy variable (time-weighted sum of pain intensity from Time 0 through 24 hours [SPI24]) was compared once at a 2-sided 0.05 level. Therefore, no multiplicity adjustment was necessary for the primary efficacy analysis. Pain Intensity was assessed by the subject using the 11-point NRS, where 0 indicated no pain and 10 indicated worst pain possible. Minimum value would be 0 and Maximum value would be 240. Time-weighted SPI is calculated as the sum of the pain intensities between successive time points (i.e., if SPI24 = ∑[PI x (time t - time t-1)], where t represents a given time point,t-1 represents the previous time point, and time is expressed in hours). This represents the AUC (Area Under the Curve) of the pain intensities when calculated with the trapezoidal rule." (NCT02525133)
Timeframe: 0 to 24 hours
| Intervention | units on a scale (Mean) |
|---|---|
| XaraColl | 88.3 |
| Placebo | 116.2 |
"Time-weighted sum of pain intensity from Time 0 through 48 hours (SPI48). Lower score has a better outcome. Pain Intensity was assessed by the subject using the 11-point NRS, where 0 indicated no pain and 10 indicated worst pain possible. Minimum value would be 0 and Maximum value would be 480. Time-weighted SPI is calculated as the sum of the pain intensities between successive time points (i.e., if SPI48 = ∑[PI x (time t - time t-1)], where t represents a given time point,t-1 represents the previous time point, and time is expressed in hours). This represents the AUC (Area Under the Curve) of the pain intensities when calculated with the trapezoidal rule." (NCT02525133)
Timeframe: 0 to 48 hours
| Intervention | units on a scale (Median) |
|---|---|
| XaraColl | 188.1 |
| Placebo | 214.9 |
"Time-weighted sum of pain intensity from Time 0 through 72 hours (SPI72) A lower score is a better outcome. Pain Intensity was assessed by the subject using the 11-point NRS, where 0 indicated no pain and 10 indicated worst pain possible Minimum value would be 0 and Maximum value would be 720. Time-weighted SPI is calculated as the sum of the pain intensities between successive time points (i.e., if SPI72 = ∑[PI x (time t - time t-1)], where t represents a given time point,t-1 represents the previous time point, and time is expressed in hours). This represents the AUC (Area Under the Curve) of the pain intensities when calculated with the trapezoidal rule." (NCT02525133)
Timeframe: 0 to 72 hours
| Intervention | units on a scale (Median) |
|---|---|
| XaraColl | 264.5 |
| Placebo | 299.7 |
"Total use of opioid analgesia (TOpA) from Time 0 through 24 hours (TOpA24) This is a basic measurement of counting in total the number of morphine tablets (15 mg) patients had to use within a 24-hour period (typically called rescue to help manage pain. Zero (0) is the lowest score. The lower the number of tablets the better outcome." (NCT02525133)
Timeframe: Time 0 through 24 hours
| Intervention | morphine equivalents (Median) |
|---|---|
| XaraColl | 5.0 |
| Placebo | 14 |
"Total use of opioid analgesia (TOpA) from Time 0 through 48 hours (TOpA48) This is a basic measurement of counting in total the number of morphine tablets (15 mg) patients had use within a 48-hour period (typically called rescue to help manage pain. Zero (0) is the lowest score. The lower the number of tablets the better outcome." (NCT02525133)
Timeframe: Time 0 through 48 hours
| Intervention | morphine equivalent (Median) |
|---|---|
| XaraColl | 5 |
| Placebo | 14 |
"Total use of opioid analgesia (TOpA) from Time 0 through 72 hours (TOpA72) This is a basic measurement of counting in total the number of morphine tablets (15 mg) patients had use within a 72-hour period (typically called rescue to help manage pain. Zero (0) is the lowest score. The lower the number of tablets the better outcome." (NCT02525133)
Timeframe: Time 0 through 72 hours
| Intervention | morphine tablets (Median) |
|---|---|
| XaraColl | 10 |
| Placebo | 20 |
"Sum of Pain Intensity (SPI24). The time weighted sum of pain intensity from 0 to 24 hours (ie, the area under the NRS PI curve from 0 to 24 hours). Where 0 indicated no pain and 10 indicated worst pain possible. This type of measurement scale is called NRS or Numerical Rating Scale For the purpose of (SPI) computation, PI at Time 0 (Baseline PI) is set to zero for all patients who have test article implantation. SPI will not be calculated for randomized but not treated patients. A lower score is a better outcome. Minimum value would be 0 and Maximum value would be 240. Time-weighted SPI is calculated as the sum of the pain intensities between successive time points (i.e., if SPI24 = ∑[PI x (time t - time t-1)], where t represents a given time point,t-1 represents the previous time point, and time is expressed in hours). This represents the AUC (Area Under the Curve) of the pain intensities when calculated with the trapezoidal rule." (NCT02523599)
Timeframe: 0 to 24 hours
| Intervention | units on a scale (Mean) |
|---|---|
| XaraColl | 85.0 |
| Placebo | 106.8 |
"Sum of pain intensity (SPI).The time weighted sum of pain intensity from 0 to 48 hours (ie, the area under the NRS PI curve from 0 to 48 hours). For the purpose of SPI computation, Pain Intensity at Time 0 (Baseline PI) is set to zero for all patients who have test article implantation. Minimum value would be 0 and Maximum value would be 480. Time-weighted SPI is calculated as the sum of the pain intensities between successive time points (i.e., if SPI24 = ∑[PI x (time t - time t-1)], where t represents a given time point,t-1 represents the previous time point, and time is expressed in hours). This represents the AUC (Area Under the Curve) of the pain intensities when calculated with the trapezoidal rule." (NCT02523599)
Timeframe: 0 to 48 hours
| Intervention | units on a scale (Median) |
|---|---|
| XaraColl | 165.7 |
| Placebo | 190.1 |
"Sum of pain intensity (SPI). The time weighted sum of pain intensity from 0 to 72 hours (ie, the area under the NRS PI curve from 0 to 72 hours). For the purpose of SPI computation, PI at Time 0 (Baseline PI) is set to zero for all patients who have test article implantation. Where 0 indicates no pain and 10 indicated worst pain possible. A lower score is a better outcome. Minimum value would be 0 and Maximum value would be 720. Time-weighted SPI is calculated as the sum of the pain intensities between successive time points (i.e., if SPI72 = ∑[PI x (time t - time t-1)], where t represents a given time point,t-1 represents the previous time point, and time is expressed in hours). This represents the AUC (Area Under the Curve) of the pain intensities when calculated with the trapezoidal rule." (NCT02523599)
Timeframe: 0 to 72 hours
| Intervention | units on a scale (Median) |
|---|---|
| XaraColl | 245.2 |
| Placebo | 263.3 |
"Total use of opioid analgesia (TOpA) from Time 0 through 24 hours (TOpA24). This is a basic measurement of counting in total the number of morphine tablets (15 mg) patients had use within a 24 hour period (typically called rescue to help manage pain. Zero (0) is the lowest score. The lower the number of tablets the better outcome." (NCT02523599)
Timeframe: Time 0 through 24 hours
| Intervention | morphine mg equivalent (Median) |
|---|---|
| XaraColl | 5 |
| Placebo | 10 |
"Total use of Opioid Analgesia from Time 0 through 48 hours (TOpA48) This is a basic measurement of counting in total the number of morphine tablets (15 mg) patients had use within a 48-hour period (typically called rescue to help manage pain. Zero (0) is the lowest score. The lower the number of tablets the better outcome." (NCT02523599)
Timeframe: Time 0 through 48 hours
| Intervention | morphine mg equivalent (Median) |
|---|---|
| XaraColl | 5.0 |
| Placebo | 14.0 |
"Total use of Opioid Analgesia (TOpA) from Time 0 through 72 hours. This is a basic measurement of counting in total the number of morphine tablets patients had use within a 72-hour period (typically called rescue to help manage pain. Zero (0) is the lowest score. The lower the number of tablets the better outcome." (NCT02523599)
Timeframe: Time 0 through 72 hours
| Intervention | morphine mg equivalent (Median) |
|---|---|
| XaraColl | 5.0 |
| Placebo | 14.0 |
The effect of liposomal bupivacaine on antiemetic consumption was assessed in mg of ondansetron consumed over first 24 hours post-operatively. (NCT02659501)
Timeframe: 24 hours
| Intervention | mg of ondansetron (Mean) |
|---|---|
| Bupivacaine With Epinephrine Injections | 7.33 |
| Liposomal Bupivacaine | 5.75 |
Postoperative pain levels were determined with a numeric rating scale (NRS), rating pain from 0 - 10, where 0 = no pain, 10 = worst possible pain. Higher scores indicate a worse outcome. Pain levels were determined during routine vital signs every 4 hours post-operatively. (NCT02659501)
Timeframe: Average Pain Scores 24 hours Post-Operatively
| Intervention | score on a scale (Mean) |
|---|---|
| Bupivacaine With Epinephrine Injections | 3.66 |
| Liposomal Bupivacaine | 3.68 |
Length of hospital stay will be determined for patients in each group, in total hours. (NCT02659501)
Timeframe: 24-60 hours
| Intervention | hrs (Mean) |
|---|---|
| Bupivacaine With Epinephrine Injections | 46.7 |
| Liposomal Bupivacaine | 29.8 |
Benzodiazepine consumption, in mg of diazepam, was recorded for all patients and compared over the first 24 hours post-operatively. (NCT02659501)
Timeframe: 24 hours
| Intervention | mg of diazepam/hr (Mean) |
|---|---|
| Bupivacaine With Epinephrine Injections | 0.35 |
| Liposomal Bupivacaine | 0.18 |
Postoperative opioid consumption will be determined in each group. Opioid consumption post-operatively will be determined for patients in each group in standardized units of morphine milligram dosing equivalents per hour. (NCT02659501)
Timeframe: 24 hours
| Intervention | Morphine equivalent dosage per hour (Mean) |
|---|---|
| Bupivacaine With Epinephrine Injections | 1.31 |
| Liposomal Bupivacaine | .76 |
Mean pain intensity on movement AUC (time normalized area under the curve) during the period 0 to 72 hours post-dose. Subjects assessed their pain intensity using an 11-point Pain Intensity Numeric Rating Scale (PI-NRS) with NRS scores ranging from 0 (no pain) to 10 (worst pain possible). The pain intensity AUC on movement was computed for each subject using the standard trapezoidal rule. For the purpose of better clinical interpretability of the pain AUC, a normalized AUC was computed by dividing it using the time-interval length over which it was computed. (NCT00818363)
Timeframe: 0 to 72 hours post-dose
| Intervention | score on a scale (Mean) |
|---|---|
| Group 1: SABER-Bupivacaine | 5.35 |
| Group 2: SABER-Placebo | 5.81 |
Mean pain intensity on movement AUC (time-normalized AUC) during the period 0 to 48 hours post-dose (0 to 2 days post-dose). Subjects assessed their pain intensity using an 11-point Pain Intensity Numeric Rating Scale (PI-NRS) with NRS scores ranging from 0 (no pain) to 10 (worst pain possible). The pain intensity AUC on movement was computed for each subject using the standard trapezoidal rule. For the purpose of better clinical interpretability of the pain AUC, a normalized AUC was computed by dividing it using the time-interval length over which it was computed. (NCT00818363)
Timeframe: 0 to 48 hours post-dose
| Intervention | score on a scale (Mean) |
|---|---|
| Group 1: SABER-Bupivacaine | 5.65 |
| Group 2: SABER-Placebo | 6.14 |
Mean total morphine-equivalent dose during the period 0 to 48 hours post-dose (0 to 2 days post-dose) (NCT00818363)
Timeframe: 0 to 48 hours post-dose
| Intervention | mg (Mean) |
|---|---|
| Group 1: SABER-Bupivacaine | 37.13 |
| Group 2: SABER-Placebo | 43.70 |
Mean total morphine-equivalent dose during the period 0 to 72 hours post-dose (NCT00818363)
Timeframe: 0 to 72 hours post-dose
| Intervention | mg (Mean) |
|---|---|
| Group 1: SABER-Bupivacaine | 44.54 |
| Group 2: SABER-Placebo | 49.94 |
(NCT00818363)
Timeframe: 0 to 14 days post-dose
| Intervention | hours (Median) |
|---|---|
| Group 1: SABER-Bupivacaine | 0.43 |
| Group 2: SABER-Placebo | 0.48 |
Frequency of subject-reported opioid-related AEs during 0 to 72 hours (0 to 3 days) post-dose and during the trial: constipation, drowsiness, dizziness, nausea, vomiting, respiratory depression, and urinary retention. (NCT00818363)
Timeframe: 0 to 72 hours post-dose
| Intervention | Participants (Count of Participants) | |||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Day 0 : Constipation | Day 0 : Dizziness | Day 0 : Drowsiness | Day 0 : Nausea | Day 0 : Respiratory Depression | Day 0 : Urinary Retention | Day 0 : Vomiting | Day 1 : Constipation | Day 1 : Dizziness | Day 1 : Drowsiness | Day 1 : Nausea | Day 1 : Respiratory Depression | Day 1 : Urinary Retention | Day 1 : Vomiting | Day 2 : Constipation | Day 2 : Dizziness | Day 2 : Drowsiness | Day 2 : Nausea | Day 2 : Respiratory Depression | Day 2 : Urinary Retention | Day 2 : Vomiting | Day 3 : Constipation | Day 3 : Dizziness | Day 3 : Drowsiness | Day 3 : Nausea | Day 3 : Respiratory Depression | Day 3 : Urinary Retention | Day 3 : Vomiting | |
| Group 1: SABER-Bupivacaine | 0 | 14 | 20 | 17 | 3 | 6 | 12 | 5 | 7 | 18 | 10 | 0 | 3 | 3 | 10 | 4 | 13 | 8 | 0 | 1 | 1 | 9 | 1 | 10 | 4 | 0 | 1 | 0 |
| Group 2: SABER-Placebo | 0 | 6 | 12 | 11 | 0 | 1 | 4 | 1 | 4 | 7 | 5 | 0 | 2 | 2 | 5 | 3 | 8 | 2 | 0 | 1 | 0 | 4 | 0 | 2 | 1 | 0 | 0 | 0 |
Pain intensity AUC over the time period of 1 to 48 hours. Data on pain intensity were collected using a 0 to 10 NRS with scores ranging from 0 (no pain) to 10 (worst pain possible). The AUC is computed for each patient using the standard trapezoidal rule and normalised by dividing by the time interval over which it is computed. This normalisation converts the AUC to the natural pain scale (NRS 0-10) to allow for better translation of the clinical treatment effect magnitude. (NCT00974350)
Timeframe: 1 to 48 hours post-dose
| Intervention | score on a scale (Least Squares Mean) |
|---|---|
| Group 1: SABER-Bupivacaine | 3.4 |
| Group 2: SABER-Bupivacaine | 2.8 |
| Group 3: SABER-Placebo | 4.1 |
Pain intensity on movement normalized AUC over the time period 1 to 72 hours post-surgery. Data on pain intensity were collected using a 0 to 10 NRS with scores ranging from 0 (no pain) to 10 (worst pain possible). The AUC is computed for each patient using the standard trapezoidal rule and normalised by dividing by the time interval over which it is computed. This normalisation converts the AUC to the natural pain scale (NRS 0-10) to allow for better translation of the clinical treatment effect magnitude. (NCT00974350)
Timeframe: 1 to 72 hours post-dose
| Intervention | score on a scale (Least Squares Mean) |
|---|---|
| Group 1: SABER-Bupivacaine | 3.4 |
| Group 2: SABER-Bupivacaine | 2.7 |
| Group 3: SABER-Placebo | 3.9 |
(NCT00974350)
Timeframe: 0 to 14 days post-dose
| Intervention | Participants (Count of Participants) |
|---|---|
| Group 1: SABER-Bupivacaine | 31 |
| Group 2: SABER-Bupivacaine | 25 |
| Group 3: SABER-Placebo | 23 |
(NCT00974350)
Timeframe: 0 to 14 days post-dose
| Intervention | Total morphine equivalent dose (mg) (Mean) |
|---|---|
| Group 1: SABER-Bupivacaine | 17.7 |
| Group 2: SABER-Bupivacaine | 12.5 |
| Group 3: SABER-Placebo | 38.4 |
In past 24 hours, pain interfered with ability to function or perform activity (0-10 numeric scale, 0=no interference) (NCT00974350)
Timeframe: 1 to 5 days post-dose
| Intervention | score on a scale (Mean) | |||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| get out of bed (Day 1) | get out of bed (Day 2) | get out of bed (Day 3) | get out of bed (Day 4) | get out of bed (Day 5) | Ability to walk (Day 1) | Ability to walk (Day 2) | Ability to walk (Day 3) | Ability to walk (Day 4) | Ability to walk (Day 5) | Ability To Interact With Visitors (Day 1) | Ability To Interact With Visitors (Day 2) | Ability To Interact With Visitors (Day 3) | Ability To Interact With Visitors (Day 4) | Ability To Interact With Visitors (Day 5) | Ability To Fall Asleep (Day 1) | Ability To Fall Asleep (Day 2) | Ability To Fall Asleep (Day 3) | Ability To Fall Asleep (Day 4) | Ability To Fall Asleep (Day 5) | Ability To Stay Asleep (Day 1) | Ability To Stay Asleep (Day 2) | Ability To Stay Asleep (Day 3) | Ability To Stay Asleep (Day 4) | Ability To Stay Asleep (Day 5) | Ability To Eat (Day 1) | Ability To Eat (Day 2) | Ability To Eat (Day 3) | Ability To Eat (Day 4) | Ability To Eat (Day 5) | Ability To Deep Breath (Day 1) | Ability To Deep Breath (Day 2) | Ability To Deep Breath (Day 3) | Ability To Deep Breath (Day 4) | Ability To Deep Breath (Day 5) | Ability To Cough (Day 1) | Ability To Cough (Day 2) | Ability To Cough (Day 3) | Ability To Cough (Day 4) | Ability To Cough (Day 5) | |
| Group 1: SABER-Bupivacaine | 3.2 | 3.0 | 2.5 | 1.7 | 1.7 | 3.5 | 2.8 | 2.5 | 2.0 | 1.8 | 1.1 | 1.0 | 0.7 | 0.7 | 0.5 | 2.7 | 2.0 | 1.5 | 1.4 | 1.1 | 2.6 | 2.0 | 1.4 | 1.2 | 1.1 | 1.2 | 0.9 | 0.5 | 0.4 | 0.3 | 1.5 | 1.2 | 1.4 | 1.1 | 0.8 | 4.4 | 4.4 | 3.9 | 3.2 | 3.0 |
| Group 2: SABER-Bupivacaine | 2.7 | 2.4 | 1.5 | 1.1 | 1.1 | 2.7 | 2.3 | 1.4 | 1.0 | 1.3 | 0.7 | 1.0 | 0.4 | 0.4 | 0.4 | 2.0 | 1.3 | 0.9 | 0.6 | 0.5 | 2.2 | 1.4 | 0.7 | 0.5 | 0.7 | 0.4 | 0.3 | 0.2 | 0.2 | 0.1 | 0.7 | 0.8 | 0.5 | 0.5 | 0.4 | 3.8 | 3.4 | 2.9 | 2.3 | 2.2 |
| Group 3: SABER-Placebo | 4.6 | 3.0 | 2.1 | 1.9 | 1.4 | 3.9 | 2.3 | 1.5 | 1.7 | 1.3 | 1.4 | 1.1 | 0.6 | 0.5 | 0.3 | 2.6 | 1.8 | 1.2 | 1.3 | 0.8 | 2.1 | 1.8 | 1.2 | 1.3 | 0.7 | 0.9 | 0.5 | 0.4 | 0.3 | 0.3 | 1.5 | 1.1 | 0.7 | 0.7 | 0.4 | 5.7 | 5.0 | 4.5 | 3.5 | 3.1 |
Modified Brief Pain Inventory -An overall assessment of treatment satisfaction was made using 6 point verbal rating scale (very dissatisfied, dissatisfied, slightly dissatisfied, slightly satisfied, satisfied, very satisfied). (NCT00974350)
Timeframe: 1 to 5 days post-dose
| Intervention | Participants (Count of Participants) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Day 172016917 | Day 172016918 | Day 172016916 | Day 272016916 | Day 272016918 | Day 272016917 | Day 372016916 | Day 372016917 | Day 372016918 | Day 472016916 | Day 472016917 | Day 472016918 | Day 572016916 | Day 572016917 | Day 572016918 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Slightly Dissatisfied | Slightly Satisfied | Satisfied | Very Satisfied | Very Dissatisfied | Dissatisfied | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Group 1: SABER-Bupivacaine | 2 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Group 2: SABER-Bupivacaine | 2 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Group 1: SABER-Bupivacaine | 1 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Group 3: SABER-Placebo | 2 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Group 2: SABER-Bupivacaine | 4 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Group 3: SABER-Placebo | 4 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Group 1: SABER-Bupivacaine | 15 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Group 2: SABER-Bupivacaine | 16 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Group 1: SABER-Bupivacaine | 21 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Group 1: SABER-Bupivacaine | 4 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Group 2: SABER-Bupivacaine | 3 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Group 2: SABER-Bupivacaine | 19 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Group 1: SABER-Bupivacaine | 3 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Group 1: SABER-Bupivacaine | 13 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Group 2: SABER-Bupivacaine | 23 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Group 1: SABER-Bupivacaine | 26 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Group 2: SABER-Bupivacaine | 20 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Group 2: SABER-Bupivacaine | 0 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Group 2: SABER-Bupivacaine | 1 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Group 3: SABER-Placebo | 3 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Group 1: SABER-Bupivacaine | 18 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Group 2: SABER-Bupivacaine | 21 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Group 3: SABER-Placebo | 12 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Group 2: SABER-Bupivacaine | 22 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Group 3: SABER-Placebo | 13 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Group 1: SABER-Bupivacaine | 0 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Group 3: SABER-Placebo | 0 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Group 3: SABER-Placebo | 1 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Group 1: SABER-Bupivacaine | 16 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Group 2: SABER-Bupivacaine | 17 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Group 3: SABER-Placebo | 11 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Group 2: SABER-Bupivacaine | 24 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Group 3: SABER-Placebo | 14 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
(NCT03007966)
Timeframe: 24 hrs Post Nerve Block
| Intervention | Participants (Count of Participants) |
|---|---|
| Ilioinguinal / Iliohypogastric Block | 2 |
| Quadratus Lumborum Block | 3 |
(NCT03007966)
Timeframe: 8 hrs Post Nerve Block
| Intervention | Participants (Count of Participants) |
|---|---|
| Ilioinguinal / Iliohypogastric Block | 0 |
| Quadratus Lumborum Block | 4 |
(NCT03007966)
Timeframe: 24 hrs Post Nerve Block
| Intervention | Participants (Count of Participants) |
|---|---|
| Ilioinguinal / Iliohypogastric Block | 6 |
| Quadratus Lumborum Block | 3 |
(NCT03007966)
Timeframe: 8 hrs Post Nerve Block
| Intervention | Participants (Count of Participants) |
|---|---|
| Ilioinguinal / Iliohypogastric Block | 9 |
| Quadratus Lumborum Block | 5 |
(NCT03007966)
Timeframe: 24 hrs Post Nerve Block
| Intervention | Participants (Count of Participants) |
|---|---|
| Ilioinguinal / Iliohypogastric Block | 3 |
| Quadratus Lumborum Block | 2 |
(NCT03007966)
Timeframe: 8 hrs Post Nerve Block
| Intervention | Participants (Count of Participants) |
|---|---|
| Ilioinguinal / Iliohypogastric Block | 3 |
| Quadratus Lumborum Block | 3 |
Assessed on an 11 point (0-10) numeric analog scale with a higher score denoting a worse outcome (NCT03007966)
Timeframe: 24 hrs Post Nerve Block
| Intervention | score on a scale (Mean) |
|---|---|
| Ilioinguinal / Iliohypogastric Block | 3 |
| Quadratus Lumborum Block | 2.7 |
Assessed on an 11-point (0-10) numeric analog scale with a higher score denoting a worse outcome (NCT03007966)
Timeframe: 8 hrs Post Nerve Block
| Intervention | score on a scale (Mean) |
|---|---|
| Ilioinguinal / Iliohypogastric Block | 3.6 |
| Quadratus Lumborum Block | 3.3 |
Assessed on an 11 point (0-10) numeric analog scale with a higher score denoting a worse outcome (NCT03007966)
Timeframe: 24hrs Post Nerve Block
| Intervention | score on a scale (Mean) |
|---|---|
| Ilioinguinal / Iliohypogastric Block | 4.9 |
| Quadratus Lumborum Block | 5.3 |
Assessed on an 11-point (0-10) numeric analog scale with a higher score denoting a worse outcome. (NCT03007966)
Timeframe: 8 hrs Post Nerve Block
| Intervention | score on a scale (Mean) |
|---|---|
| Ilioinguinal / Iliohypogastric Block | 5.10 |
| Quadratus Lumborum Block | 5.03 |
When does the patient require their first post operative analgesic dose? (NCT03007966)
Timeframe: 24hrs Post Nerve Block
| Intervention | minutes (Median) |
|---|---|
| Ilioinguinal / Iliohypogastric Block | 141 |
| Quadratus Lumborum Block | 91 |
Total opioids consumed during the first 24hrs post operatively. Measured as 24hr Oxycodone Equivalent (NCT03007966)
Timeframe: 24 hrs Post Nerve Block
| Intervention | milligrams (Mean) |
|---|---|
| Ilioinguinal / Iliohypogastric Block | 19.7 |
| Quadratus Lumborum Block | 25.2 |
The secondary outcomes that will be measured in this study include the amount of anti-emetic medication used in the first 24 hours post-op. This data will be attained by reviewing the medical record and through the validated survey questions. (NCT01602692)
Timeframe: Up to 24 hours following surgery
| Intervention | micrograms (Mean) |
|---|---|
| Tumescent Solution With Dilute Epinephrine | 131.30 |
| Tumescent Solution With Dilute Lidocaine and Epinephrine | 120.00 |
The patient's medical record will be reviewed to determine the time it took for the patient to be transitioned from the PACU (post anesthesia care unit) till discharge. This includes the time spent in the PACU, time spent in phase 2 and the total time to discharge. (NCT01602692)
Timeframe: Up to 24 hours following surgery
| Intervention | minutes (Mean) |
|---|---|
| Tumescent Solution With Dilute Epinephrine | 158 |
| Tumescent Solution With Dilute Lidocaine and Epinephrine | 153 |
The patient's medical record will be reviewed to see if the patient was readmitted to the hospital (unplanned) due to complications related to this surgery. (NCT01602692)
Timeframe: Up to 1 week following surgery
| Intervention | Participants (Count of Participants) |
|---|---|
| Tumescent Solution With Dilute Epinephrine | 0 |
| Tumescent Solution With Dilute Lidocaine and Epinephrine | 0 |
Aim 1 is to determine the effect of dilute lidocaine in tumescent solution on post-operative pain following breast reduction surgery. The amount of narcotic medication administered (in Postanesthesia Care Unit (PACU), phase 2 and up to 24 hours post-op) determined by reviewing the medical record. (NCT01602692)
Timeframe: Up to 24 hours following surgery
| Intervention | mg (Mean) | |
|---|---|---|
| PACU IV hydromorphone | First 24 hr Post-op oxycodone | |
| Tumescent Solution With Dilute Epinephrine | 0.89 | 32.19 |
| Tumescent Solution With Dilute Lidocaine and Epinephrine | 0.55 | 29.47 |
The secondary outcomes that will be measured in this study include the amount of anti-emetic medication used in the first 24 hours post-op. This data will be attained by reviewing the medical record and through the validated survey questions. (NCT01602692)
Timeframe: Up to 24 hours following surgery
| Intervention | mg (Mean) | ||||
|---|---|---|---|---|---|
| Mean Intraoperative hydromorphone | Mean Intraoperative midazolam | Mean Intraoperative ketorolac | Mean Intraoperative dexamethasone | Mean Intraoperative ondansetron | |
| Tumescent Solution With Dilute Epinephrine | 0.98 | 2.00 | 11.25 | 6.40 | 3.60 |
| Tumescent Solution With Dilute Lidocaine and Epinephrine | 1.06 | 1.90 | 16.50 | 6.00 | 4.05 |
The secondary outcomes that will be measured in this study include number of episodes of post-operative nausea (subjective feeling vs. emesis). This data will be attained by reviewing the medical record and through the validated survey questions. (NCT01602692)
Timeframe: Up to 24 hours following surgery
| Intervention | episodes (Number) | |
|---|---|---|
| Nausea | Vomiting | |
| Tumescent Solution With Dilute Epinephrine | 8 | 2 |
| Tumescent Solution With Dilute Lidocaine and Epinephrine | 10 | 4 |
Aim 1 is to determine the effect of dilute lidocaine in tumescent solution on post-operative pain following breast reduction surgery. The data points that will be statistically compared will be pain scores determined via a validated pain survey (pain levels on a scale of 0-10 where 10 is the worst pain) and the amount of narcotic medication administered (in Postanesthesia Care Unit (PACU), phase 2 and up to 24 hours post-op) determined from responses to survey questions and by reviewing the medical record. (NCT01602692)
Timeframe: Up to 24 hours following surgery
| Intervention | score on a scale (Mean) | |||
|---|---|---|---|---|
| End of PACU Mean Pain Level | First 24 hrs Post-op Mean Current Pain | First 24 hrs Post-op Mean Worst Pain | First 24 hrs Post-op Mean Least Pain | |
| Tumescent Solution With Dilute Epinephrine | 5.47 | 4.00 | 6.44 | 2.00 |
| Tumescent Solution With Dilute Lidocaine and Epinephrine | 4.47 | 4.28 | 6.68 | 2.53 |
Numeric Rating Pain Scores ( 0-10), will be obtained every 2 hours after PACU discharge up to 18 hours or until hospital discharge, whichever occurs first. The pain score of 0, means no pain, is a good outcome , and a pain score of 10 is excruciating pain, a very bad outcome. The average of these scores will be evaluated.The pain scores will not longer be documented after the numbness went away. (NCT02439281)
Timeframe: Logistic regression of the 4 th pain score assessment
| Intervention | units on a scale (Median) |
|---|---|
| Ropivacaine Group | 2 |
| Ropivacaine/ Clonidine Group | 1.5 |
The investigators hypothesize that patient postoperative anxiety scores are lower in the Ropivacaine/Clonidine group and postoperative anxiety scores decrease more in Ropivacaine /Clonidine Group, than in Ropivacaine Group. (NCT02439281)
Timeframe: 6 hours after block placement
| Intervention | units on a scale (Median) |
|---|---|
| Ropivacaine Group | 30 |
| Ropivacaine/ Clonidine Group | 29 |
The investigators expect no difference in incidence of complications (e.g. oversedation, hypotension, bradycardia episodes, etc.). (NCT02439281)
Timeframe: until study completion
| Intervention | Participants (Count of Participants) |
|---|---|
| Ropivacaine/ Clonidine Group | 1 |
| Ropivacaine Group | 1 |
The investigators hypothesize that rectus sheath injections with ropivacaine/ clonidine would result in longer duration of analgesia and decreased pain scores compared to ropivacaine alone. (NCT02439281)
Timeframe: indicated by the first request for pain medication at umbilicus site
| Intervention | minutes (Median) |
|---|---|
| Ropivacaine/ Clonidine Group | 230 |
| Ropivacaine Group | 240 |
The investigators hypothesize that rectus sheath injections with ropivacaine and clonidine result in longer duration of sensory block (paresthesia) compared to ropivacaine alone. (NCT02439281)
Timeframe: Indicated by return of normal sensation (expected average of 12 hours after block placement).
| Intervention | minutes (Median) |
|---|---|
| Ropivacaine/ Clonidine Group | 823.5 |
| Ropivacaine Group | 540 |
Total intravenous morphine equivalents mg/kg (NCT02439281)
Timeframe: 18 hours after surgery
| Intervention | mg/kg (Median) |
|---|---|
| Ropivacaine/ Clonidine Group | 0.20 |
| Ropivacaine Group | 0.22 |
The investigators hypothesize that rectus sheath injections with ropivacaine/ clonidine would result in better satisfaction with pain control. (NCT02439281)
Timeframe: Prior to hospital discharge (up to 24 hours after surgery)
| Intervention | units on a scale (Median) |
|---|---|
| Ropivacaine/ Clonidine Group | 9 |
| Ropivacaine Group | 9 |
Forced expiratory volume in 1 sec (FEV1) preoperatively and at 24 - hour interval. Then the values were analyzed as percentage in change from per-surgery measurement (post-surgery/pre-surgery). (NCT01949480)
Timeframe: Preoperatively and postoperatively
| Intervention | percentage in change from per-surgery (Mean) |
|---|---|
| Traditional Approach Paravertebral Nerve Block | 0.561 |
| Ultrasound Assisted Paravertebral Nerve Block | 0.571 |
Forced vital capacity (FVC) measured preoperatively and at 24 - hour interval. Then values were analyzed as percentage in change from per-surgery measurement (post-surgery/pre-surgery). (NCT01949480)
Timeframe: Preoperatively and postoperatively
| Intervention | percentage in change from per-surgery (Mean) |
|---|---|
| Traditional Approach Paravertebral Nerve Block | 0.551 |
| Ultrasound Assisted Paravertebral Nerve Block | 0.504 |
Inspiratory Volume as measured by incentive spirometer preoperatively and at 24 hours post PCA initiation. The data is reported as a percentage in change from per-surgery measurements (post-surgery/pre-surgery). (NCT01949480)
Timeframe: Preoperatively and Postoperatively
| Intervention | percentage in change from per-surgery (Mean) |
|---|---|
| Traditional Approach Paravertebral Nerve Block | 0.658 |
| Ultrasound Assisted Paravertebral Nerve Block | 0.716 |
Inspired oxygen concentration and SpO2 preoperatively and at 24 - hour interval. Value reported is an average of the preoperative and the 24-hour postoperative SpO2 measurements. (NCT01949480)
Timeframe: Pre-operatively and at 24 hour post-operative
| Intervention | Percentage of SpO2 (Mean) |
|---|---|
| Traditional Approach Paravertebral Nerve Block | 95 |
| Ultrasound Assisted Paravertebral Nerve Block | 94 |
The number of local anesthetic boluses over 24- hour period post PCA initiation will also be recorded. (NCT01949480)
Timeframe: 24 hours postoperatively
| Intervention | Number of boluses requested (Mean) |
|---|---|
| Traditional Approach Paravertebral Nerve Block | 27.5 |
| Ultrasound Assisted Paravertebral Nerve Block | 48 |
Hydromorphone (Dilaudid) consumption or opiate equivalent at 24-hour interval post PCA initiation at the post-anesthesia care unit (PACU). (NCT01949480)
Timeframe: 24 hours after patient-controlled analgesia (PCA) was initiated
| Intervention | mg (Mean) |
|---|---|
| Traditional Approach Paravertebral Nerve Block | 5.75 |
| Ultrasound Assisted Paravertebral Nerve Block | 6.38 |
Peak expiratory flow rate preoperatively (PEF) and at 24 - hour interval. Then values were analyzed as percentage in change from per-surgery measurement (post-surgery/pre-surgery). (NCT01949480)
Timeframe: Preoperatively and postoperatively
| Intervention | percentage in change from per-surgery (Mean) |
|---|---|
| Traditional Approach Paravertebral Nerve Block | 0.568 |
| Ultrasound Assisted Paravertebral Nerve Block | 0.542 |
Respiratory rate (RR) per minute after surgery. (NCT01949480)
Timeframe: 24 hours postoperatively
| Intervention | breaths per one minute (Mean) |
|---|---|
| Traditional Approach Paravertebral Nerve Block | 17 |
| Ultrasound Assisted Paravertebral Nerve Block | 17.7 |
Sensory level as assessed by temperature and pin prick test assessed every 5 min for 30 min after nerve block as defined as the patient returning to their bed. Data below are in number of patients who didn't have any change during the ice and pin prik test. (NCT01949480)
Timeframe: 6 assessments starting 5 minutes after nerve block and ending 30 minutes after nerve block.
| Intervention | Participants (Count of Participants) |
|---|---|
| Traditional Approach Paravertebral Nerve Block | 3 |
| Ultrasound Assisted Paravertebral Nerve Block | 1 |
The total local anesthetic infusions over 24- hour period. (NCT01949480)
Timeframe: 24 hours postoperatively
| Intervention | mL (Mean) |
|---|---|
| Traditional Approach Paravertebral Nerve Block | 173 |
| Ultrasound Assisted Paravertebral Nerve Block | 186 |
Total Number of Local Anesthetic bolus doses given within the 24-hours post-operatively. (NCT01949480)
Timeframe: postoperatively, up to 24 hours
| Intervention | number of boluses (Mean) |
|---|---|
| Traditional Approach Paravertebral Nerve Block | 1 |
| Ultrasound Assisted Paravertebral Nerve Block | 2 |
The pain level assessed using an 11-point numerical rating scale (NRS) with 0 indicating no pain and 10 indicating the worst pain possible with deep breathing and rest at 24 hours post PCA initiation. (NCT01949480)
Timeframe: 24 hours post PCA initiation
| Intervention | units on a scale (Mean) | |
|---|---|---|
| NRS at rest after 24 hrs | NRS during deep inspiration at 24 hrs | |
| Traditional Approach Paravertebral Nerve Block | 1.73 | 4 |
| Ultrasound Assisted Paravertebral Nerve Block | 2.92 | 4.77 |
"The patients self reported quality of recovery - 40 scores as completed 24 hours after the surgical procedure.~40 questions regarding the recovery of patients on a 1 poor-5 excellent scale. Total score on scale 40 (poor recovery)-200 (excellent recovery)" (NCT01890707)
Timeframe: 24 hours
| Intervention | Units on a scale (Mean) |
|---|---|
| Deep Sedation | 183.4 |
| General Anesthesia | 177.2 |
5 reviews available for bupivacaine and Inguinal Hernia
| Article | Year |
|---|---|
Effect of extraperitoneal bupivacaine analgesia in laparoscopic inguinal hernia repair: a meta-analysis of randomized controlled trials.
Topics: Anesthetics, Local; Bupivacaine; Hernia, Inguinal; Herniorrhaphy; Humans; Laparoscopy; Pain Manageme | 2014 |
Local anesthetic infusion pump for pain management following open inguinal hernia repair: a meta-analysis.
Topics: Adult; Amides; Anesthetics, Local; Bupivacaine; Female; Hernia, Inguinal; Humans; Infusion Pumps; Ma | 2014 |
The use of a pain pump for optimal postoperative pain management.
Topics: Analgesics; Anesthetics, Local; Anterior Cruciate Ligament; Bupivacaine; Double-Blind Method; Hernia | 2006 |
[Inguinal hernia: contribution of randomized studies over the last 10 years].
Topics: Anesthetics, Local; Antibiotic Prophylaxis; Bacteremia; Bupivacaine; Hernia, Inguinal; Humans; Lapar | 1996 |
Extraperitoneal laparoscopic hernia repair with local anesthesia.
Topics: Analgesics, Opioid; Anesthetics, Inhalation; Anesthetics, Local; Bupivacaine; Hernia, Inguinal; Huma | 2001 |
151 trials available for bupivacaine and Inguinal Hernia
| Article | Year |
|---|---|
Posterior quadratus lumborum block versus posterior transversus abdominis plane block for unilateral inguinal hernia surgery.
Topics: Abdominal Muscles; Acetaminophen; Adult; Analgesics, Opioid; Anesthetics, Local; Bupivacaine; Hernia | 2022 |
Transversus abdominis plane block with different bupivacaine concentrations in children undergoing unilateral inguinal hernia repair: a single-blind randomized clinical trial.
Topics: Abdominal Muscles; Bupivacaine; Child; Hernia, Inguinal; Humans; Pain, Postoperative; Single-Blind M | 2022 |
Transversus abdominis plane block with different bupivacaine concentrations in children undergoing unilateral inguinal hernia repair: a single-blind randomized clinical trial.
Topics: Abdominal Muscles; Bupivacaine; Child; Hernia, Inguinal; Humans; Pain, Postoperative; Single-Blind M | 2022 |
Transversus abdominis plane block with different bupivacaine concentrations in children undergoing unilateral inguinal hernia repair: a single-blind randomized clinical trial.
Topics: Abdominal Muscles; Bupivacaine; Child; Hernia, Inguinal; Humans; Pain, Postoperative; Single-Blind M | 2022 |
Transversus abdominis plane block with different bupivacaine concentrations in children undergoing unilateral inguinal hernia repair: a single-blind randomized clinical trial.
Topics: Abdominal Muscles; Bupivacaine; Child; Hernia, Inguinal; Humans; Pain, Postoperative; Single-Blind M | 2022 |
Transversus abdominis plane block with different bupivacaine concentrations in children undergoing unilateral inguinal hernia repair: a single-blind randomized clinical trial.
Topics: Abdominal Muscles; Bupivacaine; Child; Hernia, Inguinal; Humans; Pain, Postoperative; Single-Blind M | 2022 |
Transversus abdominis plane block with different bupivacaine concentrations in children undergoing unilateral inguinal hernia repair: a single-blind randomized clinical trial.
Topics: Abdominal Muscles; Bupivacaine; Child; Hernia, Inguinal; Humans; Pain, Postoperative; Single-Blind M | 2022 |
Transversus abdominis plane block with different bupivacaine concentrations in children undergoing unilateral inguinal hernia repair: a single-blind randomized clinical trial.
Topics: Abdominal Muscles; Bupivacaine; Child; Hernia, Inguinal; Humans; Pain, Postoperative; Single-Blind M | 2022 |
Transversus abdominis plane block with different bupivacaine concentrations in children undergoing unilateral inguinal hernia repair: a single-blind randomized clinical trial.
Topics: Abdominal Muscles; Bupivacaine; Child; Hernia, Inguinal; Humans; Pain, Postoperative; Single-Blind M | 2022 |
Transversus abdominis plane block with different bupivacaine concentrations in children undergoing unilateral inguinal hernia repair: a single-blind randomized clinical trial.
Topics: Abdominal Muscles; Bupivacaine; Child; Hernia, Inguinal; Humans; Pain, Postoperative; Single-Blind M | 2022 |
Transversus abdominis plane block versus caudal block with bupivacaine and dexmedetomidine for unilateral inguinal hernia repair in pediatric patients: a randomized clinical trial.
Topics: Abdominal Muscles; Bupivacaine; Child; Dexmedetomidine; Hernia, Inguinal; Humans; Nerve Block | 2023 |
HTX-011 reduced pain intensity and opioid consumption versus bupivacaine HCl in herniorrhaphy: results from the phase 3 EPOCH 2 study.
Topics: Adult; Analgesics, Opioid; Anesthetics, Local; Bupivacaine; Double-Blind Method; Female; Hernia, Ing | 2019 |
Ultrasound-guided quadratus lumborum block for postoperative pain control in patients undergoing unilateral inguinal hernia repair, a comparative study between two approaches.
Topics: Adolescent; Adult; Analgesics, Opioid; Anesthesia, General; Anesthetics, Local; Bupivacaine; Female; | 2019 |
A Prospective, randomized comparative study between ultrasound-guided posterior quadratus lumborum block and ultrasound-guided ilioinguinal/iliohypogastric nerve block for pediatric inguinal herniotomy.
Topics: Anesthetics, Local; Bupivacaine; Child, Preschool; Female; Hernia, Inguinal; Herniorrhaphy; Humans; | 2020 |
Effect of perineural bupivacaine infiltration on reducing inguinodynia in patients undergoing inguinal meshplasty - a randomized controlled trial.
Topics: Anesthetics, Local; Bupivacaine; Double-Blind Method; Hernia, Inguinal; Humans; Pain, Postoperative | 2022 |
A Comparison of Three Different Volumes of Levobupivacaine for Caudal Block in Children Undergoing Orchidopexy and Inguinal Hernia Repair.
Topics: Adjuvants, Anesthesia; Analysis of Variance; Anesthesia, Caudal; Anesthetics, Local; Bupivacaine; Ch | 2017 |
Protective multimodal analgesia with etoricoxib and spinal anesthesia in inguinal hernia repair: a randomized controlled trial.
Topics: Adult; Analgesia; Analgesics; Anesthesia, Spinal; Anesthetics, Local; Bupivacaine; Double-Blind Meth | 2017 |
Pre-peritoneal local anaesthetic does not reduce post-operative pain in laparoscopic total extra-peritoneal inguinal hernia repair: double-blinded randomized controlled trial.
Topics: Adult; Aged; Anesthetics, Local; Bupivacaine; Double-Blind Method; Female; Hernia, Inguinal; Hernior | 2017 |
Postoperative analgesic efficacy of ultrasound-guided ilioinguinal-iliohypogastric nerve block compared with medial transverse abdominis plane block in inguinal hernia repair: A prospective, randomised trial.
Topics: Abdominal Muscles; Adult; Anesthetics, Local; Bupivacaine; Hernia, Inguinal; Herniorrhaphy; Humans; | 2019 |
Laparoscopic-assisted transversus abdominis plane block as an effective analgesic in total extraperitoneal inguinal hernia repair: a double-blind, randomized controlled trial.
Topics: Abdominal Muscles; Anesthetics, Local; Bupivacaine; Double-Blind Method; Elective Surgical Procedure | 2018 |
Clinical effects of intrathecal fentanyl on shoulder tip pain in laparoscopic total extraperitoneal inguinal hernia repair under spinal anaesthesia: a double-blind, prospective, randomized controlled trial.
Topics: Abdomen; Adult; Aged; Analgesics, Opioid; Anesthesia, Spinal; Bupivacaine; Double-Blind Method; Fema | 2013 |
[Comparison of ilioinguinal-iliohypogastric nerve block versus spinal anesthesia techniques for single sided inguinal herniorrhaphy].
Topics: Anesthesia, Spinal; Anesthetics, Local; Bupivacaine; Female; Hernia, Inguinal; Herniorrhaphy; Humans | 2013 |
Local anesthesia for treatment of hernia in elder patients: Levobupicavaine or Bupivacaine?
Topics: Aged; Aged, 80 and over; Anesthesia, Local; Anesthetics, Local; Bupivacaine; Double-Blind Method; Fe | 2013 |
Ultrasound-guided transversus abdominis plane block in patients undergoing open inguinal hernia repair: 0.125% bupivacaine provides similar analgesic effect compared to 0.25% bupivacaine.
Topics: Abdominal Muscles; Adult; Aged; Analgesics, Opioid; Anesthesia, Spinal; Anesthetics, Local; Bupivaca | 2016 |
Effect of cooled hyperbaric bupivacaine on unilateral spinal anesthesia success rate and hemodynamic complications in inguinal hernia surgery.
Topics: Adolescent; Adult; Anesthesia, Spinal; Anesthetics, Local; Bradycardia; Bupivacaine; Elective Surgic | 2016 |
Unilateral paravertebral block compared with subarachnoid anesthesia for the management of postoperative pain syndrome after inguinal herniorrhaphy: a randomized controlled clinical trial.
Topics: Adolescent; Adult; Aged; Analysis of Variance; Anesthesia, Spinal; Anesthetics, Local; Bupivacaine; | 2016 |
Effects of bupivacaine infiltration on postoperative tramadol consumption in elective day care unilateral inguinal hernia repair.
Topics: Adult; Aged; Ambulatory Surgical Procedures; Analgesics, Opioid; Anesthesia, Local; Anesthetics, Loc | 2016 |
The role of peripheral afferents in persistent inguinal postherniorrhaphy pain: a randomized, double-blind, placebo-controlled, crossover trial of ultrasound-guided tender point blockade.
Topics: Adult; Aged; Aged, 80 and over; Anesthetics, Local; Bupivacaine; Cross-Over Studies; Double-Blind Me | 2016 |
The role of peripheral afferents in persistent inguinal postherniorrhaphy pain: a randomized, double-blind, placebo-controlled, crossover trial of ultrasound-guided tender point blockade.
Topics: Adult; Aged; Aged, 80 and over; Anesthetics, Local; Bupivacaine; Cross-Over Studies; Double-Blind Me | 2016 |
The role of peripheral afferents in persistent inguinal postherniorrhaphy pain: a randomized, double-blind, placebo-controlled, crossover trial of ultrasound-guided tender point blockade.
Topics: Adult; Aged; Aged, 80 and over; Anesthetics, Local; Bupivacaine; Cross-Over Studies; Double-Blind Me | 2016 |
The role of peripheral afferents in persistent inguinal postherniorrhaphy pain: a randomized, double-blind, placebo-controlled, crossover trial of ultrasound-guided tender point blockade.
Topics: Adult; Aged; Aged, 80 and over; Anesthetics, Local; Bupivacaine; Cross-Over Studies; Double-Blind Me | 2016 |
Perineural bupivacaine injection reduces inguinodynia after inguinal hernia repair.
Topics: Anesthetics, Local; Bupivacaine; Female; Hernia, Inguinal; Herniorrhaphy; Humans; Length of Stay; Ma | 2016 |
Randomized comparison of the feasibility of three anesthetic techniques for day-case open inguinal hernia repair.
Topics: Adult; Aged; Ambulatory Surgical Procedures; Amides; Anesthesia; Anesthesia Recovery Period; Anesthe | 2016 |
Caudal analgesia for herniotomy: Comparative evaluation of two dose schemes of bupivacaine.
Topics: Analgesia; Anesthesia, Caudal; Anesthetics, Local; Bupivacaine; Child; Child, Preschool; Dose-Respon | 2017 |
Dexmedetomidine decreases the required amount of bupivacaine for ultrasound-guided transversus abdominis plane block in pediatrics patients: a randomized study.
Topics: Abdominal Muscles; Adrenergic alpha-2 Receptor Agonists; Anesthetics, Local; Blood Pressure; Bupivac | 2017 |
Effects on QTc Interval of 2 Different Doses of Spinal Anesthesia in Inguinal Hernia Operations.
Topics: Adult; Anesthesia, Spinal; Anesthetics, Local; Arrhythmias, Cardiac; Arterial Pressure; Bupivacaine; | 2017 |
Pre-emptive infiltration of Bupivacaine in laparoscopic total extraperitoneal hernioplasty: a randomized controlled trial.
Topics: Adolescent; Adult; Aged; Anesthesia, Local; Anesthetics, Local; Bupivacaine; Female; Follow-Up Studi | 2009 |
Effect of dexmedetomidine on the characteristics of bupivacaine in a caudal block in pediatrics.
Topics: Adjuvants, Anesthesia; Adrenergic alpha-Agonists; Analgesics, Non-Narcotic; Anesthesia, Caudal; Anes | 2009 |
Effect of dexmedetomidine on the characteristics of bupivacaine in a caudal block in pediatrics.
Topics: Adjuvants, Anesthesia; Adrenergic alpha-Agonists; Analgesics, Non-Narcotic; Anesthesia, Caudal; Anes | 2009 |
Effect of dexmedetomidine on the characteristics of bupivacaine in a caudal block in pediatrics.
Topics: Adjuvants, Anesthesia; Adrenergic alpha-Agonists; Analgesics, Non-Narcotic; Anesthesia, Caudal; Anes | 2009 |
Effect of dexmedetomidine on the characteristics of bupivacaine in a caudal block in pediatrics.
Topics: Adjuvants, Anesthesia; Adrenergic alpha-Agonists; Analgesics, Non-Narcotic; Anesthesia, Caudal; Anes | 2009 |
The optimum concentration of levobupivacaine for intra-operative caudal analgesia in children undergoing inguinal hernia repair at equal volumes of injectate.
Topics: Anesthesia, Caudal; Anesthesia, Inhalation; Anesthetics, Combined; Anesthetics, Local; Bupivacaine; | 2009 |
Relative analgesic potencies of levobupivacaine and ropivacaine for caudal anesthesia in children.
Topics: Amides; Anesthesia, Caudal; Anesthetics, Local; Bupivacaine; Child; Child, Preschool; Dose-Response | 2009 |
Effects of levobupivacaine infiltration on postoperative analgesia and stress response in children following inguinal hernia repair.
Topics: Anesthetics, Local; Blood Pressure; Bupivacaine; Child; Child, Preschool; Drug Administration Schedu | 2009 |
A randomized control trial of levobupivacaine, bupivacaine versus placebo extraperitoneal infusion in totally extraperitoneal laparoscopic inguinal hernioplasty.
Topics: Adult; Aged; Analgesics, Opioid; Bupivacaine; Double-Blind Method; Female; Fentanyl; Hernia, Inguina | 2010 |
A randomized controlled trial of preperitoneal bupivacaine instillation for reducing pain following laparoscopic inguinal herniorrhaphy.
Topics: Adult; Aged; Aged, 80 and over; Anesthetics, Local; Bupivacaine; Female; Follow-Up Studies; Hernia, | 2009 |
Factors determining the doses of local anesthetic agents in unilateral inguinal hernia repair.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anesthetics, Local; Bupivacaine; Feasibility Studies; Fe | 2009 |
'Dissectalgia' following TEP, a new entity: its recognition and treatment. Results of a prospective randomized controlled trial.
Topics: Adult; Analgesics, Opioid; Anesthesia, Local; Anesthetics, Local; Bupivacaine; Convalescence; Dissec | 2009 |
Relative potencies of bupivacaine, levobupivacaine, and ropivacaine for neonatal spinal anaesthesia.
Topics: Amides; Anesthesia, Spinal; Anesthetics, Local; Bupivacaine; Dose-Response Relationship, Drug; Herni | 2009 |
Three concentrations of levobupivacaine for ilioinguinal/iliohypogastric nerve block in ambulatory pediatric surgery.
Topics: Ambulatory Surgical Procedures; Anesthetics, Inhalation; Anesthetics, Local; Bupivacaine; Child; Chi | 2009 |
Unilateral paravertebral block: an alternative to conventional spinal anaesthesia for inguinal hernia repair.
Topics: Adolescent; Adult; Aged; Analgesics; Anesthesia Recovery Period; Anesthesia, Spinal; Anesthetics, In | 2010 |
Selective spinal anesthesia for inguinal herniorrhaphy.
Topics: Adolescent; Adult; Aged; Ambulatory Surgical Procedures; Amides; Anesthesia, Spinal; Bupivacaine; Do | 2009 |
Functional implications of long-term pain following outpatient inguinal herniorrhaphy--a prospective evaluation.
Topics: Activities of Daily Living; Adult; Anesthetics, Local; Bupivacaine; Double-Blind Method; Female; Fol | 2011 |
[Efficiency of bupivacaine wound subfasciale infiltration in reduction of postoperative pain after inguinal hernia surgery].
Topics: Adult; Analgesics, Opioid; Anesthetics, Local; Body Temperature; Bupivacaine; Chronic Disease; Cough | 2010 |
Levobupivacaine-tramadol combination for caudal block in children: a randomized, double-blinded, prospective study.
Topics: Ambulatory Surgical Procedures; Analgesics, Opioid; Anesthesia, Caudal; Anesthetics, Local; Blood Pr | 2010 |
Effects of intrathecal fentanyl on quality of spinal anesthesia in children undergoing inguinal hernia repair.
Topics: Abdominal Pain; Adolescent; Anesthesia, Spinal; Anesthetics, Intravenous; Anesthetics, Local; Bupiva | 2010 |
Infiltration of wounds and extraperitoneal space with local anesthetic in patients undergoing laparoscopic totally extraperitoneal repair of unilateral inguinal hernias: a randomized double-blind placebo-controlled trial.
Topics: Adult; Aged; Anesthesia, Local; Anesthetics, Local; Bupivacaine; Cohort Studies; Double-Blind Method | 2010 |
Efficacy of bupivacaine-neostigmine and bupivacaine-tramadol in caudal block in pediatric inguinal herniorrhaphy.
Topics: Anesthesia, Caudal; Anesthetics, Local; Bupivacaine; Child; Child, Preschool; Conscious Sedation; Do | 2010 |
Effect of epidural clonidine on minimum local anesthetic concentration (ED50) of levobupivacaine for caudal block in children.
Topics: Adjuvants, Anesthesia; Adrenergic alpha-Agonists; Analgesia, Epidural; Anesthesia, Caudal; Anestheti | 2011 |
Comparison between ultrasound-guided transversus abdominis plane and conventional ilioinguinal/iliohypogastric nerve blocks for day-case open inguinal hernia repair.
Topics: Abdominal Muscles; Adult; Aged; Aged, 80 and over; Ambulatory Surgical Procedures; Anesthesia, Gener | 2011 |
Comparison between ultrasound-guided transversus abdominis plane and conventional ilioinguinal/iliohypogastric nerve blocks for day-case open inguinal hernia repair.
Topics: Abdominal Muscles; Adult; Aged; Aged, 80 and over; Ambulatory Surgical Procedures; Anesthesia, Gener | 2011 |
Comparison between ultrasound-guided transversus abdominis plane and conventional ilioinguinal/iliohypogastric nerve blocks for day-case open inguinal hernia repair.
Topics: Abdominal Muscles; Adult; Aged; Aged, 80 and over; Ambulatory Surgical Procedures; Anesthesia, Gener | 2011 |
Comparison between ultrasound-guided transversus abdominis plane and conventional ilioinguinal/iliohypogastric nerve blocks for day-case open inguinal hernia repair.
Topics: Abdominal Muscles; Adult; Aged; Aged, 80 and over; Ambulatory Surgical Procedures; Anesthesia, Gener | 2011 |
Comparison between ultrasound-guided transversus abdominis plane and conventional ilioinguinal/iliohypogastric nerve blocks for day-case open inguinal hernia repair.
Topics: Abdominal Muscles; Adult; Aged; Aged, 80 and over; Ambulatory Surgical Procedures; Anesthesia, Gener | 2011 |
Comparison between ultrasound-guided transversus abdominis plane and conventional ilioinguinal/iliohypogastric nerve blocks for day-case open inguinal hernia repair.
Topics: Abdominal Muscles; Adult; Aged; Aged, 80 and over; Ambulatory Surgical Procedures; Anesthesia, Gener | 2011 |
Comparison between ultrasound-guided transversus abdominis plane and conventional ilioinguinal/iliohypogastric nerve blocks for day-case open inguinal hernia repair.
Topics: Abdominal Muscles; Adult; Aged; Aged, 80 and over; Ambulatory Surgical Procedures; Anesthesia, Gener | 2011 |
Comparison between ultrasound-guided transversus abdominis plane and conventional ilioinguinal/iliohypogastric nerve blocks for day-case open inguinal hernia repair.
Topics: Abdominal Muscles; Adult; Aged; Aged, 80 and over; Ambulatory Surgical Procedures; Anesthesia, Gener | 2011 |
Comparison between ultrasound-guided transversus abdominis plane and conventional ilioinguinal/iliohypogastric nerve blocks for day-case open inguinal hernia repair.
Topics: Abdominal Muscles; Adult; Aged; Aged, 80 and over; Ambulatory Surgical Procedures; Anesthesia, Gener | 2011 |
Low-dose ropivacaine or levobupivacaine walking spinal anesthesia in ambulatory inguinal herniorrhaphy.
Topics: Adult; Aged; Ambulatory Surgical Procedures; Amides; Anesthesia, Epidural; Anesthesia, Spinal; Anest | 2011 |
Randomised comparison of hyperbaric articaine and hyperbaric low-dose bupivacaine along with fentanyl in spinal anaesthesia for day-case inguinal herniorrhaphy.
Topics: Adolescent; Adult; Aged; Ambulatory Surgical Procedures; Analgesics, Opioid; Analysis of Variance; A | 2012 |
Single level paravertebral versus caudal block in paediatric inguinal surgery.
Topics: Analgesics, Opioid; Anesthesia, Caudal; Anesthetics, Inhalation; Anesthetics, Local; Blood Pressure; | 2011 |
Safety and efficacy of extended-release bupivacaine local anaesthetic in open hernia repair: a randomized controlled trial.
Topics: Adolescent; Adult; Aged; Anesthesia, General; Anesthetics, Local; Bupivacaine; Delayed-Action Prepar | 2012 |
Safety and efficacy of extended-release bupivacaine local anaesthetic in open hernia repair: a randomized controlled trial.
Topics: Adolescent; Adult; Aged; Anesthesia, General; Anesthetics, Local; Bupivacaine; Delayed-Action Prepar | 2012 |
Safety and efficacy of extended-release bupivacaine local anaesthetic in open hernia repair: a randomized controlled trial.
Topics: Adolescent; Adult; Aged; Anesthesia, General; Anesthetics, Local; Bupivacaine; Delayed-Action Prepar | 2012 |
Safety and efficacy of extended-release bupivacaine local anaesthetic in open hernia repair: a randomized controlled trial.
Topics: Adolescent; Adult; Aged; Anesthesia, General; Anesthetics, Local; Bupivacaine; Delayed-Action Prepar | 2012 |
Spinal anesthesia at the L2-3 and L3-4 levels: comparison of analgesia and hemodynamic response.
Topics: Adult; Aged; Anesthesia, Spinal; Anesthetics, Local; Bradycardia; Bupivacaine; Hemodynamics; Hernia, | 2012 |
Comparison of post operative pain relief between paracetamol and wound infiltration with levobupivacaine in inguinal hernia repair.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anesthetics, Local; Bupivacaine; Child; Child, Preschool; F | 2012 |
The effect of preemptive analgesia with bupivacaine on postoperative pain of inguinal hernia repair under spinal anesthesia: a randomized clinical trial.
Topics: Adult; Analgesics, Opioid; Anesthesia, Spinal; Anesthetics, Local; Bupivacaine; Double-Blind Method; | 2013 |
Outpatient inguinal hernia repair under local anaesthesia: feasibility and efficacy of ultrasound-guided transversus abdominis plane block.
Topics: Abdominal Muscles; Adult; Aged; Ambulatory Surgical Procedures; Anesthesia, Local; Anesthetics, Loca | 2013 |
Outpatient inguinal hernia repair under local anaesthesia: feasibility and efficacy of ultrasound-guided transversus abdominis plane block.
Topics: Abdominal Muscles; Adult; Aged; Ambulatory Surgical Procedures; Anesthesia, Local; Anesthetics, Loca | 2013 |
Outpatient inguinal hernia repair under local anaesthesia: feasibility and efficacy of ultrasound-guided transversus abdominis plane block.
Topics: Abdominal Muscles; Adult; Aged; Ambulatory Surgical Procedures; Anesthesia, Local; Anesthetics, Loca | 2013 |
Outpatient inguinal hernia repair under local anaesthesia: feasibility and efficacy of ultrasound-guided transversus abdominis plane block.
Topics: Abdominal Muscles; Adult; Aged; Ambulatory Surgical Procedures; Anesthesia, Local; Anesthetics, Loca | 2013 |
Caudal dexmedetomidine combined with bupivacaine inhibit the response to hernial sac traction in children undergoing inguinal hernia repair.
Topics: Adjuvants, Anesthesia; Adrenergic alpha-Agonists; Analgesics, Opioid; Anesthesia, Caudal; Anesthesia | 2013 |
Caudal dexmedetomidine combined with bupivacaine inhibit the response to hernial sac traction in children undergoing inguinal hernia repair.
Topics: Adjuvants, Anesthesia; Adrenergic alpha-Agonists; Analgesics, Opioid; Anesthesia, Caudal; Anesthesia | 2013 |
Caudal dexmedetomidine combined with bupivacaine inhibit the response to hernial sac traction in children undergoing inguinal hernia repair.
Topics: Adjuvants, Anesthesia; Adrenergic alpha-Agonists; Analgesics, Opioid; Anesthesia, Caudal; Anesthesia | 2013 |
Caudal dexmedetomidine combined with bupivacaine inhibit the response to hernial sac traction in children undergoing inguinal hernia repair.
Topics: Adjuvants, Anesthesia; Adrenergic alpha-Agonists; Analgesics, Opioid; Anesthesia, Caudal; Anesthesia | 2013 |
Comparative study between Levobupivacaine and Bupivacaine for hernia surgery in the elderly.
Topics: Aged; Aged, 80 and over; Analgesics; Analysis of Variance; Anesthesia, Local; Anesthetics, Local; Bu | 2012 |
Spinal anaesthesia for inguinal herniotomy in preterm infants sedated with nitrous oxide: a comparison of lumbar puncture in the lateral or sitting position.
Topics: Anesthesia, Spinal; Anesthetics, Local; Blood Pressure; Bupivacaine; Conscious Sedation; Female; Hea | 2002 |
Local anaesthesia in elective inguinal hernia repair: a randomised, double-blind study comparing the efficacy of levobupivacaine with racemic bupivacaine.
Topics: Adolescent; Adult; Analysis of Variance; Anesthesia, Local; Anesthetics, Local; Bupivacaine; Double- | 2002 |
Low-dose bupivacaine plus fentanyl for spinal anesthesia during ambulatory inguinal herniorrhaphy: a comparison between 6 mg and 7. 5 mg of bupivacaine.
Topics: Adult; Aged; Ambulatory Surgical Procedures; Anesthesia, Spinal; Anesthetics, Intravenous; Anestheti | 2003 |
Effect of route of buprenorphine on recovery and postoperative analgesic requirement in paediatric patients.
Topics: Adolescent; Analgesics, Opioid; Anesthesia Recovery Period; Anesthetics, Local; Bupivacaine; Bupreno | 2002 |
Efficacy and safety of caudal injection of levobupivacaine, 0.25%, in children under 2 years of age undergoing inguinal hernia repair, circumcision or orchidopexy.
Topics: Anesthesia, Caudal; Anesthetics, Local; Bupivacaine; Circumcision, Male; Female; Hernia, Inguinal; H | 2003 |
Comparison of fentanyl-bupivacaine or midazolam-bupivacaine mixtures with plain bupivacaine for caudal anaesthesia in children.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Anesthesia Recovery Period; Anesthesia, Caudal; Anestheti | 2003 |
Clonidine combined with small-dose bupivacaine during spinal anesthesia for inguinal herniorrhaphy: a randomized double-blinded study.
Topics: Adrenergic alpha-Agonists; Adult; Anesthesia, General; Anesthesia, Spinal; Anesthetics, Local; Bupiv | 2003 |
Randomized clinical trial of postoperative subfascial infusion with bupivacaine following ambulatory open mesh repair of inguinal hernia.
Topics: Adult; Aged; Ambulatory Surgical Procedures; Anesthetics, Local; Bupivacaine; Female; Hernia, Inguin | 2003 |
Caudal neostigmine for postoperative analgesia in paediatric surgery.
Topics: Anesthesia, Caudal; Anesthetics, Combined; Anesthetics, Local; Bupivacaine; Child, Preschool; Double | 2003 |
The dose of caudal epidural analgesia and duration of postoperative analgesia.
Topics: Analgesia, Epidural; Anesthetics, Local; Bupivacaine; Child; Child, Preschool; Dose-Response Relatio | 2003 |
Comparison between instillation of bupivacaine versus caudal analgesia for postoperative analgesia following inguinal herniotomy in children.
Topics: Analgesics, Opioid; Anesthesia, Caudal; Anesthetics, Local; Bupivacaine; Child, Preschool; Digestive | 2003 |
A comparison of three different concentrations of levobupivacaine for caudal block in children.
Topics: Anesthesia, Caudal; Anesthetics, Local; Bupivacaine; Child; Child, Preschool; Dose-Response Relation | 2003 |
Clonidine prolongs spinal anesthesia in newborns: a prospective dose-ranging study.
Topics: Adrenergic alpha-Agonists; Anesthesia, Spinal; Anesthetics, Local; Bupivacaine; Clonidine; Dose-Resp | 2004 |
Analgesia and discharge following preincisional ilioinguinal and iliohypogastric nerve block combined with general or spinal anaesthesia for inguinal herniorrhaphy.
Topics: Adult; Aged; Ambulatory Surgical Procedures; Analgesia; Analgesics, Opioid; Anesthesia, General; Ane | 2004 |
Analgesia and discharge following preincisional ilioinguinal and iliohypogastric nerve block combined with general or spinal anaesthesia for inguinal herniorrhaphy.
Topics: Adult; Aged; Ambulatory Surgical Procedures; Analgesia; Analgesics, Opioid; Anesthesia, General; Ane | 2004 |
Analgesia and discharge following preincisional ilioinguinal and iliohypogastric nerve block combined with general or spinal anaesthesia for inguinal herniorrhaphy.
Topics: Adult; Aged; Ambulatory Surgical Procedures; Analgesia; Analgesics, Opioid; Anesthesia, General; Ane | 2004 |
Analgesia and discharge following preincisional ilioinguinal and iliohypogastric nerve block combined with general or spinal anaesthesia for inguinal herniorrhaphy.
Topics: Adult; Aged; Ambulatory Surgical Procedures; Analgesia; Analgesics, Opioid; Anesthesia, General; Ane | 2004 |
Comparison of ropivacaine with bupivacaine and lidocaine for ilioinguinal block after ambulatory inguinal hernia repair in children.
Topics: Ambulatory Surgical Procedures; Amides; Analgesics; Anesthetics, Local; Bupivacaine; Child; Child, P | 2004 |
Analgesic effect of clonidine added to bupivacaine 0.125% in paediatric caudal blockade.
Topics: Adrenergic alpha-Agonists; Analgesics; Anesthesia, Caudal; Anesthetics, Local; Bupivacaine; Child, P | 2004 |
Preperitoneal bupivacaine attenuates pain following laparoscopic inguinal hernia repair.
Topics: Analgesics, Opioid; Anesthetics, Local; Bupivacaine; Double-Blind Method; Drug Therapy, Combination; | 2004 |
Comparison of caudal bupivacaine and bupivacaine-midazolam for peri and postoperative analgesia in children.
Topics: Adjuvants, Anesthesia; Analgesia; Anesthetics, Local; Bupivacaine; Child; Drug Combinations; Female; | 2004 |
Continuous local anesthetic infusion for pain management after outpatient inguinal herniorrhaphy.
Topics: Adult; Ambulatory Surgical Procedures; Anesthetics, Local; Biocompatible Materials; Bupivacaine; Dou | 2004 |
A prospective, randomized, double-blind comparison of unilateral spinal anesthesia with hyperbaric bupivacaine, ropivacaine, or levobupivacaine for inguinal herniorrhaphy.
Topics: Aged; Air Pressure; Amides; Anesthesia, Spinal; Anesthetics, Local; Bupivacaine; Digestive System Su | 2004 |
Local anesthetic infusion pumps improve postoperative pain after inguinal hernia repair: a randomized trial.
Topics: Adolescent; Adult; Anesthetics, Local; Bupivacaine; Double-Blind Method; Female; Hernia, Inguinal; H | 2004 |
Evaluation of continuous infusion of 0.5% bupivacaine by elastomeric pump for postoperative pain management after open inguinal hernia repair.
Topics: Adult; Analgesics, Opioid; Anesthesia, Local; Anesthetics, Local; Bupivacaine; Double-Blind Method; | 2005 |
Combined ilioinguinal blockade and local infiltration anaesthesia for groin hernia repair--a double-blind randomized study.
Topics: Adult; Aged; Aged, 80 and over; Anesthesia, Local; Anesthetics, Local; Bupivacaine; Double-Blind Met | 2005 |
A prospective study comparing the analgesic efficacy of levobupivacaine, ropivacaine and bupivacaine in pediatric patients undergoing caudal blockade.
Topics: Amides; Anesthesia, Caudal; Anesthetics, Local; Bupivacaine; Child; Child, Preschool; Digestive Syst | 2005 |
Ultrasonography for ilioinguinal/iliohypogastric nerve blocks in children.
Topics: Ambulatory Surgical Procedures; Anesthetics, Combined; Anesthetics, Local; Bupivacaine; Child; Crypt | 2005 |
Ultrasonography for ilioinguinal/iliohypogastric nerve blocks in children.
Topics: Ambulatory Surgical Procedures; Anesthetics, Combined; Anesthetics, Local; Bupivacaine; Child; Crypt | 2005 |
Ultrasonography for ilioinguinal/iliohypogastric nerve blocks in children.
Topics: Ambulatory Surgical Procedures; Anesthetics, Combined; Anesthetics, Local; Bupivacaine; Child; Crypt | 2005 |
Ultrasonography for ilioinguinal/iliohypogastric nerve blocks in children.
Topics: Ambulatory Surgical Procedures; Anesthetics, Combined; Anesthetics, Local; Bupivacaine; Child; Crypt | 2005 |
Ultrasonography for ilioinguinal/iliohypogastric nerve blocks in children.
Topics: Ambulatory Surgical Procedures; Anesthetics, Combined; Anesthetics, Local; Bupivacaine; Child; Crypt | 2005 |
Ultrasonography for ilioinguinal/iliohypogastric nerve blocks in children.
Topics: Ambulatory Surgical Procedures; Anesthetics, Combined; Anesthetics, Local; Bupivacaine; Child; Crypt | 2005 |
Ultrasonography for ilioinguinal/iliohypogastric nerve blocks in children.
Topics: Ambulatory Surgical Procedures; Anesthetics, Combined; Anesthetics, Local; Bupivacaine; Child; Crypt | 2005 |
Ultrasonography for ilioinguinal/iliohypogastric nerve blocks in children.
Topics: Ambulatory Surgical Procedures; Anesthetics, Combined; Anesthetics, Local; Bupivacaine; Child; Crypt | 2005 |
Ultrasonography for ilioinguinal/iliohypogastric nerve blocks in children.
Topics: Ambulatory Surgical Procedures; Anesthetics, Combined; Anesthetics, Local; Bupivacaine; Child; Crypt | 2005 |
Ultrasonography for ilioinguinal/iliohypogastric nerve blocks in children.
Topics: Ambulatory Surgical Procedures; Anesthetics, Combined; Anesthetics, Local; Bupivacaine; Child; Crypt | 2005 |
Ultrasonography for ilioinguinal/iliohypogastric nerve blocks in children.
Topics: Ambulatory Surgical Procedures; Anesthetics, Combined; Anesthetics, Local; Bupivacaine; Child; Crypt | 2005 |
Ultrasonography for ilioinguinal/iliohypogastric nerve blocks in children.
Topics: Ambulatory Surgical Procedures; Anesthetics, Combined; Anesthetics, Local; Bupivacaine; Child; Crypt | 2005 |
Ultrasonography for ilioinguinal/iliohypogastric nerve blocks in children.
Topics: Ambulatory Surgical Procedures; Anesthetics, Combined; Anesthetics, Local; Bupivacaine; Child; Crypt | 2005 |
Ultrasonography for ilioinguinal/iliohypogastric nerve blocks in children.
Topics: Ambulatory Surgical Procedures; Anesthetics, Combined; Anesthetics, Local; Bupivacaine; Child; Crypt | 2005 |
Ultrasonography for ilioinguinal/iliohypogastric nerve blocks in children.
Topics: Ambulatory Surgical Procedures; Anesthetics, Combined; Anesthetics, Local; Bupivacaine; Child; Crypt | 2005 |
Ultrasonography for ilioinguinal/iliohypogastric nerve blocks in children.
Topics: Ambulatory Surgical Procedures; Anesthetics, Combined; Anesthetics, Local; Bupivacaine; Child; Crypt | 2005 |
Clonidine added to bupivacaine in neonatal spinal anesthesia: a prospective comparison in 124 preterm and term infants.
Topics: Adjuvants, Anesthesia; Analgesics; Anesthesia, Spinal; Anesthetics, Local; Bupivacaine; Clonidine; H | 2005 |
Clonidine added to bupivacaine in neonatal spinal anesthesia: a prospective comparison in 124 preterm and term infants.
Topics: Adjuvants, Anesthesia; Analgesics; Anesthesia, Spinal; Anesthetics, Local; Bupivacaine; Clonidine; H | 2005 |
Clonidine added to bupivacaine in neonatal spinal anesthesia: a prospective comparison in 124 preterm and term infants.
Topics: Adjuvants, Anesthesia; Analgesics; Anesthesia, Spinal; Anesthetics, Local; Bupivacaine; Clonidine; H | 2005 |
Clonidine added to bupivacaine in neonatal spinal anesthesia: a prospective comparison in 124 preterm and term infants.
Topics: Adjuvants, Anesthesia; Analgesics; Anesthesia, Spinal; Anesthetics, Local; Bupivacaine; Clonidine; H | 2005 |
Clonidine addition prolongs the duration of caudal analgesia.
Topics: Adjuvants, Anesthesia; Anesthesia, Caudal; Anesthetics, Local; Bupivacaine; Child; Child, Preschool; | 2006 |
Efficacy of three doses of tramadol with bupivacaine for caudal analgesia in paediatric inguinal herniotomy.
Topics: Acetaminophen; Analgesia, Epidural; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthesia Recover | 2006 |
Skin temperature during sympathetic block: a clinical comparison of bupivacaine 0.5% and ropivacaine 0.5% or 0.75%.
Topics: Amides; Anesthesia, Epidural; Anesthetics, Local; Autonomic Nerve Block; Bupivacaine; Double-Blind M | 2006 |
Does tramadol wound infiltration offer an advantage over bupivacaine for postoperative analgesia in children following herniotomy?
Topics: Administration, Topical; Analgesics, Opioid; Anesthetics, Local; Bupivacaine; Child, Preschool; Fema | 2006 |
Combined subfascial and subcutaneous bupivacaine instillation for inguinal hernia wounds.
Topics: Adult; Aged; Anesthetics, Local; Bupivacaine; Hernia, Inguinal; Humans; Injections, Subcutaneous; In | 2006 |
The effect of intravenous administration of dexamethasone on postoperative pain, nausea, and vomiting after intrathecal injection of meperidine.
Topics: Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthesia, Spinal; Anesthetics, Local; Anti-In | 2007 |
Postoperative analgesia requirements at home after inguinal hernia repair: effects of wound infiltration on postoperative pain.
Topics: Aged; Ambulatory Surgical Procedures; Analgesia, Patient-Controlled; Analgesics; Anesthetics, Local; | 2007 |
When to add supplemental rectal paracetamol for postoperative analgesia with caudal bupivacaine in children? A prospective, double-blind, randomized study.
Topics: Acetaminophen; Administration, Rectal; Analgesia; Analgesics, Non-Narcotic; Anesthesia, Caudal; Anes | 2007 |
Wound infiltration with levobupivacaine: an alternative method of postoperative pain relief after inguinal hernia repair in children.
Topics: Acetaminophen; Administration, Rectal; Analgesics, Non-Narcotic; Anesthetics, Local; Bupivacaine; Ch | 2007 |
Investigating the effect of intra-operative infiltration with local anaesthesia on the development of chronic postoperative pain after inguinal hernia repair. A randomized placebo controlled triple blinded and group sequential study design [NCT00484731].
Topics: Adolescent; Adult; Anesthetics, Local; Bupivacaine; Chronic Disease; Cross-Over Studies; Double-Blin | 2007 |
Comparison of caudal epidural bupivacaine with bupivacaine plus tramadol and bupivacaine plus ketamine for postoperative analgesia in children.
Topics: Acetaminophen; Analgesia, Epidural; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthetics, Disso | 2008 |
Caudal block for postoperative analgesia in children.
Topics: Anesthesia, Caudal; Anesthesia, Epidural; Arousal; Bupivacaine; Child; Child, Preschool; Circumcisio | 1982 |
Prolonged local analgesia for inguinal herniorrhaphy with bupivacaine and dextran.
Topics: Anesthesia, Local; Bupivacaine; Clinical Trials as Topic; Dextrans; Double-Blind Method; Epinephrine | 1982 |
Outpatient inguinal herniorrhaphy with both regional and local anesthesia.
Topics: Adolescent; Adult; Aged; Ambulatory Surgical Procedures; Anesthesia, Conduction; Anesthesia, Epidura | 1984 |
Analgesia after herniotomy in a paediatric day unit.
Topics: Bupivacaine; Child; Child, Preschool; Hernia, Inguinal; Humans; Nerve Block; Pain, Postoperative | 1982 |
Subcutaneous bupivacaine for postoperative analgesia after herniorrhaphy.
Topics: Adolescent; Adult; Aged; Analgesia; Bupivacaine; Female; Hernia, Inguinal; Humans; Injections, Subcu | 1983 |
Comparison of i.m. and local infiltration of ketorolac with and without local anaesthetic.
Topics: Administration, Topical; Adult; Aged; Ambulatory Surgical Procedures; Analgesics; Anesthetics, Local | 1995 |
Midazolam for caudal analgesia in children: comparison with caudal bupivacaine.
Topics: Analgesia, Epidural; Analgesics; Bupivacaine; Child; Child, Preschool; Double-Blind Method; Hernia, | 1995 |
Pain relief after inguinal hernia repair: a randomized double-blind study.
Topics: Administration, Oral; Adolescent; Adult; Aged; Ambulatory Surgical Procedures; Analgesics; Aspirin; | 1995 |
The effect of a combination of rectal diclofenac and caudal bupivacaine on postoperative analgesia in children.
Topics: Administration, Rectal; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Autonomic Nerve | 1995 |
Wound infiltration with ropivacaine and bupivacaine for pain after inguinal herniotomy.
Topics: Adolescent; Adult; Aged; Amides; Analgesics; Anesthetics, Local; Bupivacaine; Cough; Double-Blind Me | 1995 |
Regional anaesthesia for hernia repair in children: local vs caudal anaesthesia.
Topics: Acetaminophen; Adolescent; Anesthesia Recovery Period; Anesthesia, Caudal; Anesthesia, Local; Bupiva | 1995 |
Post-herniorrhaphy pain in outpatients after pre-incision ilioinguinal-hypogastric nerve block during monitored anaesthesia care.
Topics: Ambulatory Surgical Procedures; Analgesics; Anesthesia Recovery Period; Anesthesia, Intravenous; Bup | 1995 |
Postoperative pain relief in children. A comparison between caudal bupivacaine and intramuscular diclofenac sodium.
Topics: Analgesia, Epidural; Bupivacaine; Child; Child, Preschool; Cryptorchidism; Diclofenac; Drug Administ | 1994 |
The addition of triamcinolone acetonide to bupivacaine has no effect on the quality of analgesia produced by ilioinguinal nerve block.
Topics: Analgesia, Patient-Controlled; Bupivacaine; Hernia, Inguinal; Humans; Male; Middle Aged; Morphine; N | 1994 |
The effects of wound infiltration with bupivacaine versus saline on postoperative pain and opioid requirements after herniorrhaphy.
Topics: Adult; Aged; Analgesia; Anesthesia, Intravenous; Bupivacaine; Cough; Double-Blind Method; Hernia, In | 1994 |
Effect of ilioinguinal and iliohypogastric nerve block and wound infiltration with 0.5% bupivacaine on postoperative pain after hernia repair.
Topics: Adult; Anesthesia, Local; Bupivacaine; Double-Blind Method; Hernia, Inguinal; Humans; Male; Morphine | 1994 |
General versus regional anaesthesia and platelet aggregation in minor surgery.
Topics: Adenosine Diphosphate; Adolescent; Adult; Aged; Anesthesia, Epidural; Anesthesia, Intravenous; Bupiv | 1994 |
[A concept for decreasing postoperative pain after inguinal hernia operation].
Topics: Adult; Aged; Bupivacaine; Double-Blind Method; Hernia, Inguinal; Humans; Inguinal Canal; Male; Middl | 1994 |
A comparison of wound instillation and caudal block for analgesia following pediatric inguinal herniorrhaphy.
Topics: Anesthesia, Local; Bupivacaine; Cauda Equina; Child; Child, Preschool; Hernia, Inguinal; Humans; Inf | 1993 |
A comparison between ilioinguinal-iliohypogastric nerve block performed by anaesthetist or surgeon for postoperative analgesia following groin surgery in children.
Topics: Analgesia; Anesthesia, General; Anesthetics, Local; Bupivacaine; Child; Child, Preschool; Cryptorchi | 1995 |
Preoperative application of piroxicam gel compared to a local anaesthetic field block for postoperative analgesia.
Topics: Administration, Topical; Analgesics, Opioid; Anesthetics, Local; Anti-Inflammatory Agents, Non-Stero | 1996 |
[Treatment of inguinal hernias by classical approach and under local anesthesia].
Topics: Anesthesia, Local; Anesthetics, Local; Bupivacaine; Drug Therapy, Combination; Hernia, Inguinal; Hum | 1996 |
[Inguinal hernia: contribution of randomized studies over the last 10 years].
Topics: Anesthetics, Local; Antibiotic Prophylaxis; Bacteremia; Bupivacaine; Hernia, Inguinal; Humans; Lapar | 1996 |
Does the addition of clonidine affect duration of analgesia of bupivacaine wound infiltration in inguinal hernia surgery?
Topics: Adrenergic alpha-Agonists; Aged; Analgesia; Anesthetics, Local; Bupivacaine; Clonidine; Double-Blind | 1997 |
The effect of different anaesthetic agents in hearing loss following spinal anaesthesia.
Topics: Adult; Anesthesia, Spinal; Anesthetics, Local; Bupivacaine; Female; Hearing Loss, Sensorineural; Hea | 1998 |
Randomized placebo-controlled trial of local anaesthetic infusion in day-case inguinal hernia repair.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anesthetics, Local; Bupivacaine; Double-Blind Method; Fe | 1998 |
Analgesic effect of bupivacaine on extraperitoneal laparoscopic hernia repair.
Topics: Anesthetics, Local; Bupivacaine; Double-Blind Method; Hernia, Inguinal; Humans; Injections, Intraper | 1998 |
A randomized controlled trial of extraperitoneal bupivacaine analgesia in laparoscopic hernia repair.
Topics: Adolescent; Adult; Aged; Analgesia; Anesthesia, General; Anesthetics, Local; Bupivacaine; Day Care, | 1998 |
The proportion of high risk preterm infants with postoperative apnea and bradycardia is the same after general and spinal anesthesia.
Topics: Anesthesia, General; Anesthesia, Spinal; Anesthetics, Inhalation; Anesthetics, Local; Apnea; Bradyca | 1999 |
Effect of caudal block on the plasma adrenaline and noradrenaline concentrations in paediatric patients undergoing ilioinguinal herniorrhaphy.
Topics: Anesthesia, Caudal; Anesthesia, General; Anesthetics, Intravenous; Anesthetics, Local; Bupivacaine; | 1999 |
Levobupivacaine vs bupivacaine as infiltration anaesthesia in inguinal herniorrhaphy.
Topics: Adult; Aged; Aged, 80 and over; Ambulatory Surgical Procedures; Analgesics; Anesthesia, Local; Anest | 1999 |
A comparison of two concentrations of bupivacaine and adrenaline with and without fentanyl in paediatric inguinal herniorrhaphy.
Topics: Administration, Oral; Ambulatory Surgical Procedures; Analgesics; Analgesics, Opioid; Analysis of Va | 1999 |
Does the addition of fentanyl to bupivacaine in caudal epidural block have an effect on the plasma level of catecholamines in children?
Topics: Adjuvants, Anesthesia; Analgesia, Epidural; Analgesics, Opioid; Anesthetics, Combined; Anesthetics, | 2000 |
Prospective double-blind randomised study of a new regimen of pre-emptive analgesia for inguinal hernia repair: evaluation of postoperative pain course.
Topics: Adult; Aged; Analgesia; Analgesics, Non-Narcotic; Anesthetics, Local; Bupivacaine; Double-Blind Meth | 2000 |
Recovery profiles and costs of anesthesia for outpatient unilateral inguinal herniorrhaphy.
Topics: Adolescent; Adult; Aged; Ambulatory Surgical Procedures; Anesthesia Recovery Period; Anesthesia, Gen | 2000 |
Pediatric caudal block with mepivacaine, bupivacaine or a mixture of both drugs: requirement for postoperative analgesia and plasma concentration of local anesthetics.
Topics: Age Factors; Anesthesia, Caudal; Anesthetics, Local; Blood Pressure; Bupivacaine; Child, Preschool; | 2001 |
Pre-emptive analgesia with local anaesthetic for herniorrhaphy.
Topics: Adolescent; Adult; Aged; Analysis of Variance; Anesthesia, General; Anesthetics, Local; Bupivacaine; | 2001 |
A comparison between topical and infiltrative bupivacaine and intravenous meperidine for postoperative analgesia after inguinal herniorrhaphy.
Topics: Administration, Topical; Analgesics, Opioid; Anesthetics, Local; Bupivacaine; Female; Hernia, Inguin | 2001 |
Post-operative recovery after inguinal herniotomy in ex-premature infants: comparison between sevoflurane and spinal anaesthesia.
Topics: Anesthesia, Spinal; Anesthetics, Inhalation; Anesthetics, Local; Apnea; Bradycardia; Bupivacaine; He | 2001 |
Ilioinguinal and iliohypogastric nerve block revisited: single shot versus double shot technique for hernia repair in children.
Topics: Anesthetics, Local; Bupivacaine; Child; Child, Preschool; Hernia, Inguinal; Humans; Nerve Block; Sin | 2002 |
A prospective trial of analgesia following endoscopic totally extraperitoneal (TEP) inguinal hernioplasty.
Topics: Adult; Aged; Aged, 80 and over; Analgesia; Anesthetics, Local; Bupivacaine; Drug Administration Rout | 2002 |
Incisional self-administration of bupivacaine or ropivacaine provides effective analgesia after inguinal hernia repair.
Topics: Adolescent; Adult; Aged; Amides; Anesthetics, Local; Bupivacaine; Catheterization; Digestive System | 2002 |
Evaluation of dextran with local anaesthesia for short-stay inguinal herniorraphy.
Topics: Adult; Aged; Anesthesia, Local; Bupivacaine; Dextrans; Hernia, Inguinal; Humans; Length of Stay; Mid | 1979 |
A comparison of bupivacaine instillation and inguinal field block for control of pain after herniorrhaphy.
Topics: Adolescent; Adult; Aged; Bupivacaine; Female; Hernia, Inguinal; Humans; Instillation, Drug; Intraope | 1992 |
Adequacy of caudal analgesia in children after penoscrotal and inguinal surgery using 0.5 or 1.0 ml.kg-1 bupivacaine 0.125%.
Topics: Analgesia, Epidural; Bupivacaine; Child; Child, Preschool; Circumcision, Male; Double-Blind Method; | 1992 |
Ketamine for caudal analgesia in children: comparison with caudal bupivacaine.
Topics: Analgesia, Epidural; Bupivacaine; Cauda Equina; Child; Child Behavior; Child, Preschool; Double-Blin | 1991 |
The use of bupivacaine in elective inguinal herniorrhaphy as a fast and safe technique for relief of postoperative pain.
Topics: Adult; Aged; Bupivacaine; Drug Combinations; Epinephrine; Female; Hernia, Inguinal; Humans; Male; Mi | 1991 |
A comparison of postoperative analgesia provided by wound infiltration or caudal analgesia.
Topics: Analgesia, Epidural; Bupivacaine; Child; Child, Preschool; Hernia, Inguinal; Humans; Infant; Male; P | 1991 |
Paediatric postoperative analgesia. A comparison of rectal diclofenac with caudal bupivacaine after inguinal herniotomy.
Topics: Administration, Rectal; Ambulatory Surgical Procedures; Anesthesia, Caudal; Anesthesia, Epidural; Bu | 1990 |
A comparison between bupivacaine instillation versus ilioinguinal/iliohypogastric nerve block for postoperative analgesia following inguinal herniorrhaphy in children.
Topics: Anesthesia, Local; Bupivacaine; Child; Child, Preschool; Hernia, Inguinal; Humans; Hypogastric Plexu | 1990 |
Local anaesthesia in inguinal herniorrhaphy: influence of dextran and saline solutions on duration of action of bupivacaine.
Topics: Adult; Aged; Anesthesia, Local; Bupivacaine; Clinical Trials as Topic; Dextrans; Double-Blind Method | 1986 |
The prolongation of local anaesthetic action with dextran. The effect of molecular weight.
Topics: Adjuvants, Anesthesia; Adult; Anesthesia, Conduction; Bupivacaine; Dextrans; Double-Blind Method; Ep | 1985 |
Study of the effectiveness of bupivicaine infiltration of the ilioinguinal nerve at the time of hernia repair for post-operative pain relief.
Topics: Analgesics; Bupivacaine; Hernia, Inguinal; Humans; Nerve Block; Pain, Postoperative; Peripheral Nerv | 1989 |
Analgesia following inguinal herniotomy or orchidopexy in children: a comparison of caudal and regional blockade.
Topics: Analgesia; Anesthesia, Caudal; Anesthesia, Conduction; Anesthesia, Epidural; Bupivacaine; Child; Chi | 1989 |
Percutaneous inguinal block for the outpatient management of post-herniorrhaphy pain in children.
Topics: Ambulatory Surgical Procedures; Bupivacaine; Child; Child, Preschool; Clinical Trials as Topic; Hern | 1987 |
Paediatric postoperative analgesia. A comparison between caudal block and wound infiltration of local anaesthetic.
Topics: Analgesics; Anesthesia, Caudal; Anesthesia, Epidural; Anesthesia, Local; Bupivacaine; Child Behavior | 1988 |
Intraoperative bupivacaine during outpatient hernia repair in children: a randomized double blind trial.
Topics: Ambulatory Surgical Procedures; Anesthesia, General; Anesthesia, Local; Bupivacaine; Child; Child, P | 1987 |
Comparative effects of intrathecal bupivacaine and tetracaine on analgesia, cardiovascular function and plasma catecholamines.
Topics: Adult; Aged; Anesthesia, Spinal; Blood Pressure; Bupivacaine; Cardiovascular System; Catecholamines; | 1986 |
93 other studies available for bupivacaine and Inguinal Hernia
| Article | Year |
|---|---|
Bupivacaine liposome use reduces length of post-anesthesia care unit stay and postoperative narcotic use following robotic inguinal herniorrhaphy.
Topics: Analgesics; Analgesics, Opioid; Anesthesia, Local; Anesthetics, Local; Bupivacaine; Hernia, Inguinal | 2022 |
Surgeon-administered ilio-inguinal and pudendal nerve blocks for major vulval surgery: An observational study with visual analogue pain scoring.
Topics: Adult; Aged; Aged, 80 and over; Anesthetics, Local; Bupivacaine; Female; Groin; Hernia, Inguinal; Hu | 2022 |
Opioid-free recovery after herniorrhaphy with HTX-011 as the foundation of a multimodal analgesic regimen.
Topics: Adult; Aged; Analgesics, Opioid; Anesthetics, Local; Bupivacaine; Female; Hernia, Inguinal; Herniorr | 2020 |
Subcutaneous ketamine prolongs the analgesic effect of local infiltration of plain Bupivacaine in children undergoing inguinal herniotomy.
Topics: Analgesics, Opioid; Anesthesia Recovery Period; Anesthetics, Dissociative; Anesthetics, Local; Bupiv | 2020 |
Pharmacokinetics and Safety of INL-001 (Bupivacaine HCl) Implants Compared with Bupivacaine HCl Infiltration After Open Unilateral Inguinal Hernioplasty.
Topics: Anesthetics, Local; Bupivacaine; Hernia, Inguinal; Herniorrhaphy; Humans; Pain, Postoperative; Singl | 2021 |
Comparison Between the Effects of Bupivacaine and Levobupivacaine for Spinal Anesthesia on QT Dispersion.
Topics: Adult; Anesthesia, Spinal; Anesthetics, Local; Arrhythmias, Cardiac; Bupivacaine; Female; Heart Rate | 2021 |
Inguinal pain syndrome. The influence of intraoperative local administration of 0.5% bupivacaine on postoperative pain control following Lichtenstein hernioplasty. A prospective case-control study.
Topics: Ambulatory Surgical Procedures; Anesthetics, Local; Bupivacaine; Case-Control Studies; Hernia, Ingui | 2017 |
Survey on the practice of anaesthesiologists in inguinal hernia surgery in Galicia.
Topics: Ambulatory Surgical Procedures; Analgesia; Anesthesia, General; Anesthesia, Spinal; Anesthesiologist | 2018 |
Safety and Efficacy of Bupivacaine HCl Collagen-Matrix Implant (INL-001) in Open Inguinal Hernia Repair: Results from Two Randomized Controlled Trials.
Topics: Anesthetics, Local; Bupivacaine; Collagen; Double-Blind Method; Female; Hernia, Inguinal; Humans; Ma | 2019 |
Safety and Efficacy of Bupivacaine HCl Collagen-Matrix Implant (INL-001) in Open Inguinal Hernia Repair: Results from Two Randomized Controlled Trials.
Topics: Anesthetics, Local; Bupivacaine; Collagen; Double-Blind Method; Female; Hernia, Inguinal; Humans; Ma | 2019 |
Safety and Efficacy of Bupivacaine HCl Collagen-Matrix Implant (INL-001) in Open Inguinal Hernia Repair: Results from Two Randomized Controlled Trials.
Topics: Anesthetics, Local; Bupivacaine; Collagen; Double-Blind Method; Female; Hernia, Inguinal; Humans; Ma | 2019 |
Safety and Efficacy of Bupivacaine HCl Collagen-Matrix Implant (INL-001) in Open Inguinal Hernia Repair: Results from Two Randomized Controlled Trials.
Topics: Anesthetics, Local; Bupivacaine; Collagen; Double-Blind Method; Female; Hernia, Inguinal; Humans; Ma | 2019 |
[Comparison of Postoperative Analgesic Effects between 0.25% Levobupivacaine and 0.5% Levobupivacaine Local Instillation in Inguinal Hernia Repair].
Topics: Anesthetics, Local; Bupivacaine; Female; Hernia, Inguinal; Humans; Levobupivacaine; Male; Middle Age | 2015 |
Inadvertent Prolonged Femoral Nerve Palsy After Field Block with Liposomal Bupivacaine for Inguinal Herniorrhaphy.
Topics: Anesthetics, Local; Bupivacaine; Femoral Neuropathy; Hernia, Inguinal; Herniorrhaphy; Humans; Liposo | 2016 |
The novel use of different bupivacaine preparations with combined regional techniques for postoperative pain management in non-opioid-based laparoscopic inguinal herniorrhaphy.
Topics: Analgesics, Non-Narcotic; Anesthesia, General; Anesthesia, Local; Anesthesia, Spinal; Anesthetics, L | 2016 |
Local anesthetic hernia repair in overweight and obese patients.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anesthesia, Local; Anesthetics, Local; Body Mass Index; | 2009 |
Tumescent local anesthesia in inguinal herniorrhaphy with a PROLENE hernia system: original technique and results.
Topics: Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Bupivacaine; Hernia, Inguinal; Humans; | 2009 |
Local anaesthetic inguinal hernia repair performed under supervision: early and long-term outcomes.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anesthesia, Local; Anesthetics, Local; Bupivacaine; Fema | 2009 |
Temporary obturator nerve paresis after spray of local anesthetic during laparoscopic extraperitoneal inguinal hernia repair.
Topics: Anesthetics, Local; Bupivacaine; Hernia, Inguinal; Humans; Laparoscopy; Male; Middle Aged; Obturator | 2010 |
[Anaesthetic effect of acupuncture during an inguinal hernia repair – a self-experiment].
Topics: Acupuncture Analgesia; Anesthesia; Anesthetics, Local; Bupivacaine; Electroacupuncture; Hernia, Ingu | 2011 |
Awake caudal anesthesia for inguinal hernia operations: successful use in low birth weight neonates.
Topics: Anesthesia, Caudal; Anesthetics, Local; Bupivacaine; Electrocardiography; Female; Gestational Age; H | 2011 |
The safety and tolerability evaluation of DepoFoam bupivacaine (bupivacaine extended-release liposome injection) administered by incision wound infiltration in rabbits and dogs.
Topics: Anesthetics, Local; Animals; Bupivacaine; Delayed-Action Preparations; Disease Models, Animal; Dogs; | 2011 |
The safety and tolerability evaluation of DepoFoam bupivacaine (bupivacaine extended-release liposome injection) administered by incision wound infiltration in rabbits and dogs.
Topics: Anesthetics, Local; Animals; Bupivacaine; Delayed-Action Preparations; Disease Models, Animal; Dogs; | 2011 |
The safety and tolerability evaluation of DepoFoam bupivacaine (bupivacaine extended-release liposome injection) administered by incision wound infiltration in rabbits and dogs.
Topics: Anesthetics, Local; Animals; Bupivacaine; Delayed-Action Preparations; Disease Models, Animal; Dogs; | 2011 |
The safety and tolerability evaluation of DepoFoam bupivacaine (bupivacaine extended-release liposome injection) administered by incision wound infiltration in rabbits and dogs.
Topics: Anesthetics, Local; Animals; Bupivacaine; Delayed-Action Preparations; Disease Models, Animal; Dogs; | 2011 |
Postoperative pain relief following inguinal hernia repair in children by wound infiltration with levobupivacaine.
Topics: Anesthetics, Local; Bupivacaine; Child; Child, Preschool; Female; Hernia, Inguinal; Humans; Levobupi | 2011 |
Is 4% articaine suitable for spinal anaesthesia?
Topics: Ambulatory Surgical Procedures; Analgesics, Opioid; Anesthesia, Spinal; Anesthetics, Local; Bupivaca | 2012 |
Safety of articaine in spinal anaesthesia.
Topics: Ambulatory Surgical Procedures; Analgesics, Opioid; Anesthesia, Spinal; Anesthetics, Local; Bupivaca | 2012 |
Hemodynamic changes during spinal anesthesia in premature infants with congenital heart disease undergoing inguinal hernia correction.
Topics: Anesthesia, Spinal; Anesthetics, Local; Arterial Pressure; Blood Pressure; Bupivacaine; Female; Hear | 2012 |
Outpatient simultaneous repair of ventral and groin hernias in local anesthesia: case report.
Topics: Adult; Aged; Ambulatory Surgical Procedures; Anesthesia, Local; Anesthetics, Local; Bupivacaine; Fem | 2012 |
Ultrasound-guided ilioinguinal/iliohypogastric nerve blocks for chronic pain after inguinal hernia repair.
Topics: Adult; Aged; Aged, 80 and over; Analgesics; Anti-Inflammatory Agents; Bupivacaine; Chronic Pain; Ele | 2013 |
Spigelian hernia repair as a day-case procedure.
Topics: Adult; Aged; Aged, 80 and over; Ambulatory Care; Anesthesia, Local; Bupivacaine; Female; Follow-Up S | 2013 |
Apnoea in a former preterm infant after caudal bupivacaine with clonidine for inguinal herniorrhaphy.
Topics: Anesthesia, Caudal; Anesthetics, Combined; Apnea; Bupivacaine; Clonidine; Hernia, Inguinal; Humans; | 2002 |
Paravertebral block anesthesia for inguinal hernia repair.
Topics: Adult; Aged; Anesthetics, Local; Bupivacaine; Female; Hernia, Inguinal; Humans; Male; Middle Aged; N | 2003 |
Central neuraxial blockade in ambulatory surgery.
Topics: Ambulatory Surgical Procedures; Anesthesia, Epidural; Anesthesia, Spinal; Anesthetics, Local; Bupiva | 2003 |
Postoperative apnoea in an ex-premature infant: is it only related to clonidine?
Topics: Analgesics; Anesthesia, Caudal; Anesthesia, General; Anesthetics, Local; Apnea; Bupivacaine; Clonidi | 2003 |
Spinal anesthesia with bupivacaine decreases cerebral blood flow in former preterm infants.
Topics: Anesthesia, Spinal; Anesthetics, Local; Blood Pressure; Bupivacaine; Cerebrovascular Circulation; Co | 2004 |
Re: "Inguinal hernia repair" by I.M.C. MacIntyre J R Coll Surg Edinb 2001; 46: 349-53.
Topics: Anesthetics, Local; Bupivacaine; Digestive System Surgical Procedures; Hernia, Inguinal; Humans; Lid | 2003 |
Spinal anaesthesia in full-term infants of 0-6 months: are there any differences regarding age?
Topics: Aging; Anesthesia Recovery Period; Anesthesia, Spinal; Anesthetics, Local; Bupivacaine; Digestive Sy | 2005 |
Pain management after hernia repair.
Topics: Analgesics, Non-Narcotic; Anesthetics, Local; Bupivacaine; Hernia, Inguinal; Humans; Ibuprofen; Infu | 2005 |
Reduction of incarcerated inguinal hernia in infants using caudal epidural anaesthesia.
Topics: Anesthesia, Caudal; Anesthetics, Local; Bupivacaine; Hernia, Inguinal; Humans; Infant; Infant, Newbo | 2005 |
[Ilioinguinal nerve block during general anesthesia for inguinal herniorrhaphy in adult anticoagulated patients].
Topics: Aged; Anesthesia, General; Anesthesia, Spinal; Anticoagulants; Bupivacaine; Contraindications; Herni | 2006 |
Anesthetic management of a patient with stiff person syndrome.
Topics: Adjuvants, Anesthesia; Aged; Anesthetics, Intravenous; Anesthetics, Local; Bupivacaine; Fentanyl; He | 2006 |
Iliac compartment block following ilioinguinal iliohypogastric nerve block.
Topics: Anesthetics, Local; Bupivacaine; Child; Femoral Neuropathy; Hernia, Inguinal; Humans; Male; Nerve Bl | 2006 |
Spinal anesthesia for inguinal hernia repair in an infant with Williams syndrome: case report.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anesthesia, Spinal; Anesthetics, Inhalation; Anesthetics, L | 2007 |
Spinal myoclonus associated with intrathecal bupivacaine and fentanyl in an infant.
Topics: Anesthetics, Intravenous; Anesthetics, Local; Bupivacaine; Electroencephalography; Fentanyl; Hernia, | 2007 |
Local anesthesia for inguinal hernia repair in adolescents.
Topics: Adolescent; Anesthesia, Local; Anesthetics, Local; Bupivacaine; Child; Conscious Sedation; Drug Ther | 2007 |
Ultrasonography and pediatric caudals.
Topics: Anesthetics, Local; Bupivacaine; Circumcision, Male; Hernia, Inguinal; Humans; Infant; Injections; M | 2008 |
[Use of ilio-inguinal iliohypogastric nerve block for herniorraphy: a prospective study in a 35-case series at the Lome University Hospital Center in Togo].
Topics: Adult; Anesthetics, Local; Bupivacaine; Female; Guanethidine; Hernia, Inguinal; Hospitals, Universit | 2008 |
Evaluation of dextran with local anaesthesia for herniorraphy.
Topics: Anesthetics, Local; Bupivacaine; Dextrans; Hernia, Inguinal; Humans; Lidocaine | 1980 |
Accidental intrathecal injection of bupivacaine and dextran.
Topics: Adult; Anesthesia, Epidural; Bupivacaine; Dextrans; Hernia, Inguinal; Humans; Hypotension; Injection | 1981 |
Accidental intrathecal injection of bupivacaine and dextran.
Topics: Adult; Anesthesia, Epidural; Bupivacaine; Dextrans; Hernia, Inguinal; Humans; Hypotension; Injection | 1981 |
Accidental intrathecal injection of bupivacaine and dextran.
Topics: Adult; Anesthesia, Epidural; Bupivacaine; Dextrans; Hernia, Inguinal; Humans; Hypotension; Injection | 1981 |
Accidental intrathecal injection of bupivacaine and dextran.
Topics: Adult; Anesthesia, Epidural; Bupivacaine; Dextrans; Hernia, Inguinal; Humans; Hypotension; Injection | 1981 |
The effects of three differing anaesthetics on the immune response.
Topics: Adult; Anesthesia, Epidural; Anesthesia, Inhalation; Bupivacaine; Cell Migration Inhibition; Halotha | 1984 |
Subarachnoid blockade with bupivacaine. A comparison with cinchocaine.
Topics: Adolescent; Adult; Aged; Anesthesia, Spinal; Bupivacaine; Dibucaine; Female; Glucose; Hemodynamics; | 1984 |
Esophageal rupture and spinal anesthesia.
Topics: Aged; Anesthesia, Epidural; Anesthesia, Spinal; Bupivacaine; Esophageal Diseases; Hernia, Inguinal; | 1983 |
Delayed respiratory arrest after bupivacaine.
Topics: Anesthesia, Epidural; Bupivacaine; Hernia, Inguinal; Humans; Male; Middle Aged; Muscular Diseases; P | 1982 |
Postoperative analgesia for day-case herniorrhaphy patients. A comparison of cryoanalgesia, paravertebral blockade and oral analgesia.
Topics: Acetaminophen; Activities of Daily Living; Ambulatory Surgical Procedures; Analgesia; Anesthesia, Ep | 1981 |
[Delayed low back pain after spinal anesthesia].
Topics: Anesthesia, Spinal; Anesthetics, Local; Bupivacaine; Hernia, Inguinal; Humans; Low Back Pain; Magnet | 1995 |
Caudal block in a child with osteogenesis imperfecta, type II.
Topics: Anesthesia, Epidural; Anesthesia, Inhalation; Anesthetics, Local; Bupivacaine; Coccyx; Hernia, Ingui | 1995 |
Unilateral spinal analgesia in a neonate.
Topics: Anesthesia, Spinal; Bupivacaine; Hernia, Inguinal; Humans; Infant; Infant, Newborn; Infant, Prematur | 1995 |
Minimal influence of anaesthesia and abdominal surgery on computerized vectorcardiography recordings.
Topics: Adult; Aged; Anesthesia, Intravenous; Anesthesia, Spinal; Bupivacaine; Cholecystectomy; Female; Fent | 1995 |
[Lichtenstein's "tension-free" operation for inguinal hernia under local anesthesia].
Topics: Anesthesia, Local; Bupivacaine; Drug Therapy, Combination; Follow-Up Studies; Hernia, Inguinal; Huma | 1995 |
[Pain and convalescence after ambulatory inguinal herniotomy during local anesthesia].
Topics: Adult; Aged; Ambulatory Surgical Procedures; Anesthesia, Local; Bupivacaine; Convalescence; Female; | 1995 |
Caudal epidural block for analgesia following herniorrhaphy with laparoscopy in children.
Topics: Analgesia, Epidural; Bupivacaine; Child, Preschool; Female; Hernia, Inguinal; Humans; Intraoperative | 1994 |
Local anesthesia and inguinal hernia repair; a cautionary tale.
Topics: Anesthesia, Local; Bupivacaine; Child, Preschool; Femoral Nerve; Hernia, Inguinal; Humans; Male; Par | 1994 |
[Trans-sacral caudal anesthesia in ambulatory practice in infants. Our experience].
Topics: Ambulatory Surgical Procedures; Anesthesia, Caudal; Bupivacaine; Child; Child, Preschool; Cryptorchi | 1993 |
[Spinal anesthesia in infancy using bupivacaine 0.5%. The effect of an adrenaline addition on duration and hemodynamics].
Topics: Anesthesia, Spinal; Bupivacaine; Epinephrine; Hemodynamics; Hernia, Inguinal; Humans; Infant, Newbor | 1994 |
Continuous regional anaesthesia in infants.
Topics: Anesthesia, Caudal; Anesthesia, Spinal; Anesthetics, Local; Bronchopulmonary Dysplasia; Bupivacaine; | 1993 |
Electrocardiographic and hemodynamic changes associated with unintentional intravascular injection of bupivacaine with epinephrine in infants.
Topics: Anesthesia, Caudal; Bradycardia; Bupivacaine; Electrocardiography; Epinephrine; Hemodynamics; Hernia | 1993 |
[Local anesthesia and ambulatory surgery for inguinal hernia. Apropos of 737 patients].
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Ambulatory Surgical Procedures; Anesthesia, Local; Bupiv | 1993 |
Lumbar epidural anaesthesia for inguinal hernia repair in low birth weight infants.
Topics: Analgesia, Epidural; Anesthesia, Epidural; Anesthesia, Inhalation; Bupivacaine; Hernia, Inguinal; Hu | 1993 |
Plasma concentrations of bupivacaine after wound infiltration of an 0.5% solution after inguinal herniorrhaphy: a preliminary study.
Topics: Adult; Aged; Bupivacaine; Hernia, Inguinal; Humans; Male; Middle Aged; Pain, Postoperative | 1993 |
Epidural anaesthesia through caudal catheters for inguinal herniotomies in awake ex-premature babies.
Topics: Anesthesia, Caudal; Bupivacaine; Catheterization; Hernia, Inguinal; Humans; Infant; Infant, Newborn; | 1993 |
[Loco-regional anesthesia in the surgery of inguinal and crural hernias. The authors' own experience with 1730 treated cases].
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anesthesia, Conduction; Anesthesia, Local; Bupivacaine; | 1993 |
Pain relief after inguinal hernia repair: a randomized controlled trial.
Topics: Anesthetics, Local; Bupivacaine; Double-Blind Method; Hernia, Inguinal; Humans; Pain, Postoperative; | 1996 |
[Pencil-point needles: possible disadvantages to the shape of the needle].
Topics: Anesthesia, Epidural; Anesthetics, Local; Bupivacaine; Equipment Design; Female; Hernia, Inguinal; H | 1995 |
[Anesthetic management of a pediatric patient with Cornelia de Lange syndrome].
Topics: Analgesia; Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Local; Bupivacaine; Child; De | 1996 |
Experience with caudal blocks in children over a period of 3.5 years.
Topics: Abdomen; Adolescent; Analgesia; Anesthesia Recovery Period; Anesthesia, Caudal; Anesthetics, Local; | 1996 |
Simultaneous repair of bilateral inguinal hernias under local anesthesia.
Topics: Anesthesia, Local; Anesthetics, Local; Bupivacaine; Hernia, Inguinal; Humans; Lidocaine | 1997 |
[Local anesthesia in the surgery of inguinal hernia. Technical notes].
Topics: Anesthesia, Local; Anesthetics, Combined; Anesthetics, Local; Bupivacaine; Hernia, Inguinal; Humans; | 1997 |
The effects of local anesthetics on postoperative pain.
Topics: Adult; Anesthetics, Local; Bupivacaine; Hernia, Inguinal; Humans; Intraoperative Period; Lidocaine; | 1998 |
Recovery after paediatric daycase herniotomy performed under spinal anaesthesia.
Topics: Activities of Daily Living; Ambulatory Surgical Procedures; Analgesics; Anesthesia Recovery Period; | 2000 |
Increased T-wave amplitude after accidental intravascular injection of lidocaine plus bupivacaine without epinephrine in sevoflurane-anesthetized child.
Topics: Anesthesia, Caudal; Anesthetics, Inhalation; Anesthetics, Local; Bupivacaine; Electrocardiography; E | 2001 |
One-thousand consecutive inguinal hernia repairs under unmonitored local anesthesia.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Ambulatory Surgical Procedures; Anesthesia, Local; Anest | 2001 |
Feasibility of local infiltration anaesthesia for recurrent groin hernia repair.
Topics: Aged; Ambulatory Surgical Procedures; Anesthesia, Local; Anesthetics, Local; Bupivacaine; Feasibilit | 2001 |
Local anaesthesia toxicity is additive: a concern for neonatal caudal anaesthesia?
Topics: Anesthesia, Caudal; Bupivacaine; Hernia, Inguinal; Humans; Infant, Newborn; Lidocaine | 2002 |
Change in the management of adult groin hernia.
Topics: Adolescent; Adult; Aged; Anesthesia, Inhalation; Anesthesia, Spinal; Anesthetics, Local; Bupivacaine | 1978 |
Local anesthetic used in repairing inguinal hernia.
Topics: Adjuvants, Anesthesia; Adolescent; Adult; Aged; Anesthesia, Local; Bupivacaine; Female; Hernia, Ingu | 1977 |
Local anaesthesia for reduction of neonatal inguinal hernia.
Topics: Anesthesia, Local; Bupivacaine; Hernia, Inguinal; Humans; Infant, Newborn; Male | 1992 |
Elimination of urinary retention following inguinal herniorrhaphy.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anesthesia, General; Anesthesia, Local; Anesthesia, Spin | 1991 |
Serum bupivacaine concentrations following wound infiltration in children undergoing inguinal herniotomy.
Topics: Analgesia; Anesthesia, Inhalation; Anesthesia, Intravenous; Bupivacaine; Child; Child, Preschool; He | 1991 |
Femoral nerve block after intra-operative subcutaneous bupivacaine injection.
Topics: Aged; Anesthesia, Local; Bupivacaine; Femoral Nerve; Hernia, Inguinal; Humans; Male; Nerve Block; Pa | 1990 |
Respiratory arrest after a caudal injection of bupivacaine.
Topics: Anesthesia, Epidural; Bupivacaine; Child, Preschool; Cryptorchidism; De Lange Syndrome; Hernia, Ingu | 1989 |
Spinal anaesthesia in infants born prematurely.
Topics: Anesthesia, Spinal; Bupivacaine; Gestational Age; Hernia, Inguinal; Humans; Infant, Newborn; Infant, | 1989 |
Caudal block for analgesia after paediatric inguinal surgery.
Topics: Anesthesia, Caudal; Anesthesia, Epidural; Bupivacaine; Child, Preschool; Cryptorchidism; Hernia, Ing | 1987 |
Plasma bupivacaine concentrations following ilioinguinal-iliohypogastric nerve blockade in children.
Topics: Bupivacaine; Child; Child, Preschool; Groin; Hernia, Inguinal; Humans; Infant; Nerve Block | 1988 |
[Analgesia for inguinal herniorrhaphy in children: a comparison of caudal block and regional nerve block with bupivacaine].
Topics: Anesthesia, Caudal; Anesthesia, Epidural; Bupivacaine; Child; Child, Preschool; Hernia, Inguinal; Hu | 1986 |
[Comparison of hyperbaric and isobaric bupivacaine for spinal anesthesia].
Topics: Anesthesia, Spinal; Bupivacaine; Hernia, Inguinal; Humans; Tetracaine | 1985 |
Pain and mobility after inguinal herniorrhaphy: ineffectiveness of subcutaneous bupivacaine.
Topics: Bupivacaine; Hernia, Inguinal; Humans; Locomotion; Male; Pain, Postoperative; Postoperative Period | 1985 |
Transient quadriceps paresis following local inguinal block for postoperative pain control.
Topics: Bupivacaine; Child; Child, Preschool; Femoral Nerve; Hernia, Inguinal; Humans; Male; Muscular Diseas | 1985 |