Page last updated: 2024-10-24

bupivacaine and Hemorrhage, Uterine

bupivacaine has been researched along with Hemorrhage, Uterine in 3 studies

Bupivacaine: A widely used local anesthetic agent.
1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide : A piperidinecarboxamide obtained by formal condensation of the carboxy group of N-butylpipecolic acid with the amino group of 2,6-dimethylaniline.
bupivacaine : A racemate composed of equimolar amounts of dextrobupivacaine and levobupivacaine. Used (in the form of its hydrochloride hydrate) as a local anaesthetic.

Research Excerpts

Excerpt	Relevance	Reference
"However, studies of hemorrhagic shock in nonpregnant animals may not be applicable to less severe hemorrhage in pregnant animals."	1.28	Epidural anesthesia worsens uterine blood flow and fetal oxygenation during hemorrhage in gravid ewes. ( Chatterjee, P; Chestnut, DH; DeBruyn, CS; Sipes, SL; Thompson, CS; Vincent, RD, 1992)

Research

Studies (3)

Timeframe	Studies, this research(%)	All Research%
pre-1990	1 (33.33)	18.7374
1990's	1 (33.33)	18.2507
2000's	0 (0.00)	29.6817
2010's	1 (33.33)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
El Hachem, L	1
Small, E	1
Chung, P	1
Moshier, EL	1
Friedman, K	1
Fenske, SS	1
Gretz, HF	1
Vincent, RD	1
Chestnut, DH	1
Sipes, SL	1
DeBruyn, CS	1
Chatterjee, P	1
Thompson, CS	1
Mercer, WH	1
Simons, EG	1
Philpott, RH	1

Clinical Trials (1)

Trial Overview

Trial			Phase	Enrollment	Study Type	Start Date	Status
Analgesic Efficacy of Transversus Abdominis Plane Block Versus Local Injection in Postoperative Pain Management Following Minimally Invasive Gynecological Surgery[NCT02314104]				220 participants (Actual)	Interventional	2011-05-31	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Postoperative Pain on a Visual Analogue Pain Scale at One Hour Postoperatively

A Visual Analogue Scale was used. The scale range was 0 to 10 in increments of one. 0 was no pain and 10 was worst pain possible. (NCT02314104)
Timeframe: one hour postoperatively

Intervention	units on a scale (Mean)
Treatment TAP, Placebo Local Injection	4.04
Placebo TAP, Treatment Local Injection	5.09
Treatment TAP, Treatment Local Injection	4.4

Postoperative Pain on a Visual Analogue Pain Scale at Six Hours Postoperatively

A Visual Analogue Scale was used. The scale range was 0 to 10 in increments of one. 0 was no pain and 10 was worst pain possible. (NCT02314104)
Timeframe: six hours postoperatively

Intervention	units on a scale (Mean)
Treatment TAP, Placebo Local Injection	3.53
Placebo TAP, Treatment Local Injection	3.5
Treatment TAP, Treatment Local Injection	3.33

Postoperative Pain on a Visual Analogue Pain Scale at Twenty-four Hours Postoperatively

A Visual Analogue Scale was used. The scale range was 0 to 10 in increments of one. 0 was no pain and 10 was worst pain possible. (NCT02314104)
Timeframe: twenty-four hours postoperatively

Intervention	units on a scale (Mean)
Treatment TAP, Placebo Local Injection	3.36
Placebo TAP, Treatment Local Injection	3.56
Treatment TAP, Treatment Local Injection	3.51

Time Until First Request for Pain Medication

(NCT02314104)
Timeframe: up to twenty-four hours postoperatively

Intervention	minutes (Median)
Treatment TAP, Placebo Local Injection	46
Placebo TAP, Treatment Local Injection	31
Treatment TAP, Treatment Local Injection	28

Total Narcotic Usage in Morphine Equivalents

(NCT02314104)
Timeframe: up to twenty-four hours postoperatively

Intervention	mg (Mean)
Treatment TAP, Placebo Local Injection	20.09
Placebo TAP, Treatment Local Injection	23.14
Treatment TAP, Treatment Local Injection	20.68

Trials

1 trial available for bupivacaine and Hemorrhage, Uterine

Article	Year
Randomized controlled double-blind trial of transversus abdominis plane block versus trocar site infiltration in gynecologic laparoscopy. American journal of obstetrics and gynecology, 2015, Volume: 212, Issue:2 Topics: Abdominal Muscles; Adult; Aged; Anesthesia, Local; Anesthetics, Local; Bupivacaine; Cohort Studies;	2015

Other Studies

2 other studies available for bupivacaine and Hemorrhage, Uterine

Article	Year
Epidural anesthesia worsens uterine blood flow and fetal oxygenation during hemorrhage in gravid ewes. Anesthesiology, 1992, Volume: 76, Issue:5 Topics: Anesthesia, Epidural; Anesthesia, Obstetrical; Animals; Bupivacaine; Carbon Dioxide; Epinephrine; Fe	1992
The use of lumbar epidural analgesia during the first stage of labour in high-risk pregnancies. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1974, Apr-17, Volume: 48, Issue:18 Topics: Adolescent; Anesthesia, Epidural; Anesthesia, Obstetrical; Apgar Score; Bupivacaine; Delivery, Obste	1974