bupivacaine has been researched along with Heart Diseases in 32 studies
Bupivacaine: A widely used local anesthetic agent.
1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide : A piperidinecarboxamide obtained by formal condensation of the carboxy group of N-butylpipecolic acid with the amino group of 2,6-dimethylaniline.
bupivacaine : A racemate composed of equimolar amounts of dextrobupivacaine and levobupivacaine. Used (in the form of its hydrochloride hydrate) as a local anaesthetic.
Heart Diseases: Pathological conditions involving the HEART including its structural and functional abnormalities.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Cardiotoxicity can be induced by the commonly used amide local anesthetic, bupivacaine." | 8.02 | Apelin-13 Reverses Bupivacaine-Induced Cardiotoxicity via the Adenosine Monophosphate-Activated Protein Kinase Pathway. ( Cai, Y; Chen, H; Jin, Z; Liu, L; Papadimos, TJ; Shi, K; Wang, Q; Xia, E; Xia, F; Xia, Y; Xu, X; Ye, Y, 2021) |
| "Cardiotoxicity can be induced by the commonly used amide local anesthetic, bupivacaine." | 4.02 | Apelin-13 Reverses Bupivacaine-Induced Cardiotoxicity via the Adenosine Monophosphate-Activated Protein Kinase Pathway. ( Cai, Y; Chen, H; Jin, Z; Liu, L; Papadimos, TJ; Shi, K; Wang, Q; Xia, E; Xia, F; Xia, Y; Xu, X; Ye, Y, 2021) |
| " However, patients might have a better outcome with a reduction of morphine dosage and administration of a muscle relaxant of shorter duration of action than pancuronium." | 2.71 | A randomized trial of caudal block with bupivacaine 4 mg x kg-1 (1.8 ml x kg-1) plus morphine (150 microg x kg-1) vs general anaesthesia with fentanyl for cardiac surgery. ( Castillo-Zamora, C; Nava-Ocampo, AA; Rojas-Pérez, E, 2003) |
| "Hexamethonium pretreatment induced significantly less QRS widening and QTc lengthening than was seen in group 1 but worsened the bupivacaine effects on bradycardia, atria-His and PR intervals, mean aortic pressure, and first derivative of left ventricular pressure." | 1.29 | Mechanisms of the putative cardioprotective effect of hexamethonium in anesthetized dogs given a large dose of bupivacaine. ( Bassoul, B; Bruelle, P; de La Coussaye, JE; Desch, G; Eledjam, JJ; Lefrant, JY; Peray, PA; Sassine, A, 1994) |
| "The risk of toxic effects on the heart of bupivacaine following several kinds of locoregional anaesthesia has been investigated in the dog in situ heart by determining conduction time and effective refractory period in the various parts of the conduction system and the ventricular muscle, as well as the discharge rate of the sinus node." | 1.27 | Electrophysiological study in the dog of the risk of cardiac toxicity of bupivacaine. ( Béal, JL; Bertrix, L; Faucon, G; Freysz, M; Lakhal, M; Lang, J; Timour, Q, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (28.13) | 18.7374 |
| 1990's | 3 (9.38) | 18.2507 |
| 2000's | 8 (25.00) | 29.6817 |
| 2010's | 10 (31.25) | 24.3611 |
| 2020's | 2 (6.25) | 2.80 |
| Authors | Studies |
|---|---|
| Ye, Y | 1 |
| Cai, Y | 1 |
| Xia, E | 1 |
| Shi, K | 1 |
| Jin, Z | 2 |
| Chen, H | 2 |
| Xia, F | 2 |
| Xia, Y | 1 |
| Papadimos, TJ | 1 |
| Xu, X | 1 |
| Liu, L | 1 |
| Wang, Q | 1 |
| Fu, Z | 1 |
| Fettiplace, MR | 1 |
| Ripper, R | 1 |
| Lis, K | 1 |
| Feinstein, DL | 1 |
| Rubinstein, I | 1 |
| Weinberg, G | 2 |
| Bhakta, P | 1 |
| Sharma, PK | 1 |
| Date, RR | 1 |
| Mohammad, AK | 1 |
| Liao, Z | 1 |
| Xiong, Y | 1 |
| Luo, L | 1 |
| Kocabas, S | 1 |
| Yedicocuklu, D | 1 |
| Yuksel, E | 1 |
| Uysallar, E | 1 |
| Askar, F | 1 |
| Bouwman, RA | 1 |
| Vreden, MJ | 1 |
| Hamdani, N | 1 |
| Wassenaar, LE | 1 |
| Smeding, L | 1 |
| Loer, SA | 1 |
| Stienen, GJ | 1 |
| Lamberts, RR | 1 |
| Lin, EP | 1 |
| Aronson, LA | 1 |
| Fuzaylov, G | 1 |
| Ying, B | 1 |
| Tang, Y | 1 |
| Sethna, NF | 1 |
| Schwartz, DA | 1 |
| Raghunathan, K | 1 |
| Connelly, NR | 1 |
| Kiuchi, MG | 1 |
| Zapata-Sudo, G | 1 |
| Trachez, MM | 1 |
| Ririe, D | 1 |
| Sudo, RT | 1 |
| Arendt, KW | 1 |
| Fernandes, SM | 1 |
| Khairy, P | 1 |
| Warnes, CA | 1 |
| Rose, CH | 1 |
| Landzberg, MJ | 1 |
| Craigo, PA | 1 |
| Hebl, JR | 1 |
| Tsuchiya, H | 1 |
| Mizogami, M | 1 |
| Rojas-Pérez, E | 1 |
| Castillo-Zamora, C | 1 |
| Nava-Ocampo, AA | 1 |
| Kühne, J | 1 |
| Zimmer, C | 1 |
| Piepenbrink, K | 1 |
| Riest, G | 1 |
| Peters, J | 1 |
| de Jong, RH | 1 |
| de La Coussaye, JE | 2 |
| Eledjam, JJ | 2 |
| Bruelle, P | 1 |
| Lefrant, JY | 1 |
| Bassoul, B | 2 |
| Peray, PA | 1 |
| Desch, G | 1 |
| Sassine, A | 2 |
| Maxwell, LG | 1 |
| Martin, LD | 1 |
| Yaster, M | 1 |
| Morrison, SG | 1 |
| Dominguez, JJ | 1 |
| Frascarolo, P | 1 |
| Reiz, S | 1 |
| Fernández Garijo, MP | 1 |
| Velasco Andrés, D | 1 |
| Aldecoa Alvarez-Santullano, C | 1 |
| Gómez Herreras, JI | 1 |
| Kajikawa, S | 1 |
| Suzuki, M | 1 |
| Yokoi, M | 1 |
| VadeBoncouer, T | 1 |
| Widman, B | 1 |
| Fabregat, J | 1 |
| D'Athis, F | 1 |
| Timour, Q | 1 |
| Freysz, M | 1 |
| Lang, J | 1 |
| Béal, JL | 1 |
| Lakhal, M | 1 |
| Bertrix, L | 1 |
| Faucon, G | 1 |
| Nolte, H | 3 |
| Bischoff, U | 1 |
| Exler, U | 1 |
| Milatz, W | 1 |
| Morishima, HO | 1 |
| Pedersen, H | 1 |
| Finster, M | 1 |
| Hiraoka, H | 1 |
| Tsuji, A | 1 |
| Feldman, HS | 1 |
| Arthur, GR | 1 |
| Covino, BG | 1 |
| Mayat, MG | 1 |
| Motala, SA | 1 |
| Pillay, TS | 1 |
| Mercer, WH | 1 |
| Simons, EG | 1 |
| Philpott, RH | 1 |
1 review available for bupivacaine and Heart Diseases
| Article | Year |
|---|---|
Plasma concentration of local anaesthetic agents in regard to absorption, distribution and elimination, with special reference to bupivacaine.
Topics: Absorption; Anesthetics, Local; Animals; Brain; Bupivacaine; Cardiac Output; Erythrocyte Count; Eryt | 1975 |
2 trials available for bupivacaine and Heart Diseases
| Article | Year |
|---|---|
Infiltration of the sternotomy wound and the mediastinal tube sites with 0.25% levobupivacaine as adjunctive treatment for postoperative pain after cardiac surgery.
Topics: Adolescent; Adult; Aged; Anesthesia, Local; Bupivacaine; Female; Heart Diseases; Humans; Levobupivac | 2008 |
A randomized trial of caudal block with bupivacaine 4 mg x kg-1 (1.8 ml x kg-1) plus morphine (150 microg x kg-1) vs general anaesthesia with fentanyl for cardiac surgery.
Topics: Analgesics, Opioid; Anesthesia, Caudal; Anesthesia, General; Anesthetics, Combined; Anesthetics, Loc | 2003 |
29 other studies available for bupivacaine and Heart Diseases
| Article | Year |
|---|---|
Apelin-13 Reverses Bupivacaine-Induced Cardiotoxicity via the Adenosine Monophosphate-Activated Protein Kinase Pathway.
Topics: AMP-Activated Protein Kinases; Animals; Bupivacaine; Cardiotoxicity; Cell Line; Disease Models, Anim | 2021 |
SK2 channel deletion reduces susceptibility to bupivacaine-induced cardiotoxicity in mouse.
Topics: Animals; Bupivacaine; Gene Expression Regulation; Heart Diseases; Mice; Mice, Knockout; Random Alloc | 2021 |
Intraosseous lipid emulsion: an effective alternative to IV delivery in emergency situations.
Topics: Anesthetics, Local; Animals; Bupivacaine; Emergency Treatment; Emulsions; Heart Diseases; Infusions, | 2014 |
Can low dose spinal anesthesia combined with ultrasound guided bilateral ilioinguinal-iliohypogastric nerve blocks avoid use of additional epidural catheter in high risk obstetric cases? Our experience from two cases.
Topics: Adult; Anesthesia, Epidural; Anesthesia, Obstetrical; Anesthesia, Spinal; Anesthetics, Local; Bupiva | 2013 |
Low-dose spinal-epidural anesthesia for Cesarean section in a parturient with uncontrolled hyperthyroidism and thyrotoxic heart disease.
Topics: Adult; Analgesics, Opioid; Anesthesia, Epidural; Anesthesia, Obstetrical; Anesthesia, Spinal; Bupiva | 2016 |
Effect of bupivacaine on sevoflurane-induced preconditioning in isolated rat hearts.
Topics: Anesthetics, Inhalation; Anesthetics, Local; Animals; Bupivacaine; Heart; Heart Diseases; In Vitro T | 2010 |
Successful resuscitation of bupivacaine-induced cardiotoxicity in a neonate.
Topics: Anesthesia, Epidural; Anesthesia, General; Anesthetics, Local; Bupivacaine; Cardiopulmonary Resuscit | 2010 |
Successful resuscitation after inadvertent intravenous injection of bupivacaine in an adolescent.
Topics: Adolescent; Anesthetics, Local; Bupivacaine; Cardiopulmonary Resuscitation; Cleft Lip; Cleft Palate; | 2010 |
Reply to 'Successful resuscitation of bupivacaine-induced cardiotoxicity in a neonate'.
Topics: Anesthesia, Caudal; Anesthetics, Local; Bupivacaine; Cardiopulmonary Resuscitation; Circumcision, Ma | 2010 |
The influence of age on bupivacaine cardiotoxicity.
Topics: Age Factors; Animals; Animals, Newborn; Bupivacaine; Calcium; Cardiotoxins; Dose-Response Relationsh | 2011 |
A case series of the anesthetic management of parturients with surgically repaired tetralogy of Fallot.
Topics: Adult; Age Factors; Analgesia, Obstetrical; Anesthesia, Epidural; Anesthesia, Obstetrical; Anestheti | 2011 |
R(+)-, Rac-, and S(-)-bupivacaine stereostructure-specifically interact with membrane lipids at cardiotoxically relevant concentrations.
Topics: Anesthetics, Local; Bupivacaine; Cardiolipins; Cholesterol; Dose-Response Relationship, Drug; Heart | 2012 |
Loco-regional anaesthesia for a total knee arthroplasty in a high-risk cardiac patient.
Topics: Aged; Anesthesia, Conduction; Anesthesia, Local; Anesthetics, Local; Anti-Inflammatory Agents, Non-S | 2004 |
[Cardiotoxic and neurotoxic effects after accidental intravascular bupivacaine administration. Therapy with lidocaine propofol and lipid emulsion].
Topics: Aged, 80 and over; Anesthesia, Epidural; Anesthetics, Intravenous; Anesthetics, Local; Blood Pressur | 2007 |
Cardiac glycoside and beta-adrenergic blocker facilitate resuscitation from bupivacaine cardiotoxicity.
Topics: Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Bupivacaine; Digoxin | 1994 |
Mechanisms of the putative cardioprotective effect of hexamethonium in anesthetized dogs given a large dose of bupivacaine.
Topics: Anesthesia; Animals; Antihypertensive Agents; Atrial Function; Atropine; Bupivacaine; Cardiac Pacing | 1994 |
Bupivacaine-induced cardiac toxicity in neonates: successful treatment with intravenous phenytoin.
Topics: Bupivacaine; Heart Diseases; Heart Rate; Humans; Infant, Newborn; Injections, Intravenous; Male; Phe | 1994 |
A comparison of the electrocardiographic cardiotoxic effects of racemic bupivacaine, levobupivacaine, and ropivacaine in anesthetized swine.
Topics: Amides; Anesthesia; Anesthetics, Local; Animals; Blood Gas Analysis; Body Temperature; Bupivacaine; | 2000 |
[Enantiomers and local anesthetics].
Topics: Amides; Anesthetics, Local; Bupivacaine; Chemical Phenomena; Chemistry, Physical; Drug Design; Heart | 2000 |
[Preoperative complications and intraoperative hemodynamic changes in very old patients with femoral neck fractures].
Topics: Aged; Aged, 80 and over; Anemia; Anesthesia, General; Anesthesia, Spinal; Bupivacaine; Femoral Neck | 2000 |
Improved energetics may explain the favorable effect of insulin infusion on bupivacaine cardiotoxicity.
Topics: Anesthetics, Local; Animals; Bupivacaine; Dogs; Energy Metabolism; Glucose; Heart Diseases; Hypoglyc | 2001 |
[Resuscitation in a toxic cardiac accident involving bupivacaine. Experimental study].
Topics: Animals; Bupivacaine; Dogs; Heart Diseases; Resuscitation | 1989 |
Electrophysiological study in the dog of the risk of cardiac toxicity of bupivacaine.
Topics: Action Potentials; Anesthesia, Local; Animals; Blood Pressure; Bundle of His; Bupivacaine; Dogs; Ele | 1987 |
[The problem of the cardiotoxicity of bupivacaine 0.75%].
Topics: Anesthesia, Epidural; Bupivacaine; Electrocardiography; Heart Diseases; Humans | 1986 |
[Bupivacaine 0.5% and 0.75% for peridural anesthesia in operations on the extremities].
Topics: Adult; Aged; Anesthesia, Epidural; Bupivacaine; Female; Heart Diseases; Hemodynamics; Humans; Male; | 1986 |
[Monitoring of cardiac output during use of bupivacaine 0.75% by ventriculography (99mTC)].
Topics: Adult; Anesthesia, Epidural; Bupivacaine; Cardiac Output; Electrocardiography; Heart Diseases; Heart | 1986 |
Bupivacaine toxicity in pregnant and nonpregnant ewes.
Topics: Animals; Blood Pressure; Bupivacaine; Dose-Response Relationship, Drug; Etidocaine; Female; Fetus; H | 1985 |
The use of marcaine for epidural anaesthesia.
Topics: Abdomen; Aged; Anesthesia, Epidural; Anesthesia, Obstetrical; Anesthesia, Spinal; Bupivacaine; Cesar | 1973 |
The use of lumbar epidural analgesia during the first stage of labour in high-risk pregnancies.
Topics: Adolescent; Anesthesia, Epidural; Anesthesia, Obstetrical; Apgar Score; Bupivacaine; Delivery, Obste | 1974 |