bupivacaine has been researched along with Heart Arrest in 120 studies
Bupivacaine: A widely used local anesthetic agent.
1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide : A piperidinecarboxamide obtained by formal condensation of the carboxy group of N-butylpipecolic acid with the amino group of 2,6-dimethylaniline.
bupivacaine : A racemate composed of equimolar amounts of dextrobupivacaine and levobupivacaine. Used (in the form of its hydrochloride hydrate) as a local anaesthetic.
Heart Arrest: Cessation of heart beat or MYOCARDIAL CONTRACTION. If it is treated within a few minutes, heart arrest can be reversed in most cases to normal cardiac rhythm and effective circulation.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The relative efficacies of a long- and medium-chain triglyceride (LCT/MCT) emulsion and an LCT emulsion for treatment of bupivacaine (BPV)-induced cardiac toxicity are poorly defined." | 7.96 | Lipid Emulsion Restoration of Myocardial Contractions After Bupivacaine-Induced Asystole In Vitro: A Benefit of Long- and Medium-Chain Triglyceride Over Long-Chain Triglyceride. ( Jung, JR; Kim, HJ; Kim, HS; Kim, HY; Lynch, C; Park, WK, 2020) |
| "It is currently unknown whether bupivacaine-induced asystole is better resuscitated with lipid emulsion (LE) administered peripherally or centrally, and whether different LE regimens administered peripherally demonstrated similar effects." | 7.91 | Comparative Regimens of Lipid Rescue From Bupivacaine-Induced Asystole in a Rat Model. ( Cai, X; Jin, Z; Liu, L; Papadimos, TJ; Shi, K; Xia, Y; Xu, X; Zhang, M, 2019) |
| "Levosimendan is superior to epinephrine in producing higher CFs and faster recovery when reversing bupivacaine-induced asystole in the isolated rat hearts." | 7.88 | Levosimendan is superior to epinephrine on coronary flow for lipid-base resuscitation of bupivacaine-induced asystole in the isolated rat heart. ( Chen, H; Chen, L; Jin, Z; Liu, L; Papadimos, TJ; Shi, K; Xia, F; Xia, Y; Xu, X, 2018) |
| "The concentration- and time-response relationships of lipid emulsion (LE; Intralipid) on the recovery of myocardial contractility following bupivacaine (BPV)-induced asystole are poorly defined." | 7.85 | Intralipid Restoration of Myocardial Contractions Following Bupivacaine-Induced Asystole: Concentration- and Time-Dependence In Vitro. ( Jung, JR; Kim, HS; Kim, SH; Lynch, C; Min, NH; Park, WK, 2017) |
| " However, to our knowledge, it remains unknown whether EA could alleviate bupivacaine-induced cardiotoxicity." | 7.83 | Electroacupuncture pretreatment induces rapid tolerance to bupivacaine cardiotoxicity in rats. ( Gao, JL; Han, FF; Li, XX; Li, YL; Wang, XM; Zhang, DH; Zhang, HJ; Zhao, QL, 2016) |
| "The reversal efficacy of 2% lipid emulsion in cardiac asystole induced by different concentrations of bupivacaine is poorly defined and needs to be determined." | 7.80 | Measurement of the efficacy of 2% lipid in reversing bupivacaine- induced asystole in isolated rat hearts. ( Chen, H; Chen, L; Hu, X; Papadimos, TJ; Wang, Q; Wang, W; Xia, Y; Xu, S; Xu, X; Zhu, B, 2014) |
| " Bupivacaine 100 μmol/L was perfused until 3 minutes after asystole." | 7.78 | The comparative effects of lipid, epinephrine, and their combination in the reversal of bupivacaine-induced asystole in the isolated rat heart. ( Chen, Y; Liu, L; Shi, T; Small, RH; Wang, F; Wang, Q; Xia, Y; Xu, X, 2012) |
| "The concentration-response and time-response relationships of lipid emulsions used to reverse bupivacaine-induced asystole are poorly defined." | 7.76 | Lipid emulsion reverses bupivacaine-induced asystole in isolated rat hearts: concentration-response and time-response relationships. ( Chen, L; Chen, Y; Liu, L; Papadimos, TJ; Shi, K; Shi, T; Wang, Q; Xia, Y; Xu, X, 2010) |
| "75% bupivacaine hydrochloride at a rate of 10 ml x kg x min(-1) to asystole." | 7.70 | Pretreatment or resuscitation with a lipid infusion shifts the dose-response to bupivacaine-induced asystole in rats. ( Cwik, MJ; Garcia-Amaro, MF; Ramaraju, GA; VadeBoncouer, T; Weinberg, GL, 1998) |
| "The objective of this study was to compare the success of resuscitation attempts with different cardioactive drugs after bupivacaine-induced asystole." | 7.69 | Resuscitation from bupivacaine-induced asystole in rats: comparison of different cardioactive drugs. ( Heavner, JE; Pitkänen, MT; Rosenberg, PH; Shi, B, 1995) |
| "Toxic systemic reactions to bupivacaine usually involve a number of factors, including hypoxia and acidosis." | 7.68 | Severe hypoxia enhances central nervous system and cardiovascular toxicity of bupivacaine in lightly anesthetized pigs. ( Badgwell, JM; Bessire, A; Dryden, CF; Heavner, JE; Huemer, G; Sanghani, V, 1992) |
| "Time of arrhythmia, 50% mean arterial pressure- and 50% heart rate-reduction, and asystole were recorded, and ropivacaine doses were calculated." | 5.72 | Effects of nalbuphine on the cardiotoxicity of ropivacaine in rats. ( Huang, S; Jiao, J; Sun, S; Wang, C; Yu, X, 2022) |
| "Remifentanil is a selective, ultra-short-acting, µ-opioid receptor agonist opioid." | 5.48 | Effects of Remifentanil Pretreatment on Bupivacaine Cardiotoxicity in Rats. ( Ayoğlu, H; Pişkin, Ö, 2018) |
| "In this model of a bupivacaine-induced cardiac arrest, the vasopressor combination of vasopressin and epinephrine compared with lipid emulsion resulted in higher coronary perfusion pressure during CPR and survival rates." | 5.35 | A comparison of the combination of epinephrine and vasopressin with lipid emulsion in a porcine model of asphyxial cardiac arrest after intravenous injection of bupivacaine. ( Gritsch, C; Lindner, KH; Luckner, G; Mayr, VD; Mitterschiffthaler, L; Müller, T; Neurauter, A; Strohmenger, HU; Wenzel, V, 2008) |
| "The relative efficacies of a long- and medium-chain triglyceride (LCT/MCT) emulsion and an LCT emulsion for treatment of bupivacaine (BPV)-induced cardiac toxicity are poorly defined." | 3.96 | Lipid Emulsion Restoration of Myocardial Contractions After Bupivacaine-Induced Asystole In Vitro: A Benefit of Long- and Medium-Chain Triglyceride Over Long-Chain Triglyceride. ( Jung, JR; Kim, HJ; Kim, HS; Kim, HY; Lynch, C; Park, WK, 2020) |
| "It is currently unknown whether bupivacaine-induced asystole is better resuscitated with lipid emulsion (LE) administered peripherally or centrally, and whether different LE regimens administered peripherally demonstrated similar effects." | 3.91 | Comparative Regimens of Lipid Rescue From Bupivacaine-Induced Asystole in a Rat Model. ( Cai, X; Jin, Z; Liu, L; Papadimos, TJ; Shi, K; Xia, Y; Xu, X; Zhang, M, 2019) |
| "Levosimendan is superior to epinephrine in producing higher CFs and faster recovery when reversing bupivacaine-induced asystole in the isolated rat hearts." | 3.88 | Levosimendan is superior to epinephrine on coronary flow for lipid-base resuscitation of bupivacaine-induced asystole in the isolated rat heart. ( Chen, H; Chen, L; Jin, Z; Liu, L; Papadimos, TJ; Shi, K; Xia, F; Xia, Y; Xu, X, 2018) |
| "The concentration- and time-response relationships of lipid emulsion (LE; Intralipid) on the recovery of myocardial contractility following bupivacaine (BPV)-induced asystole are poorly defined." | 3.85 | Intralipid Restoration of Myocardial Contractions Following Bupivacaine-Induced Asystole: Concentration- and Time-Dependence In Vitro. ( Jung, JR; Kim, HS; Kim, SH; Lynch, C; Min, NH; Park, WK, 2017) |
| " However, to our knowledge, it remains unknown whether EA could alleviate bupivacaine-induced cardiotoxicity." | 3.83 | Electroacupuncture pretreatment induces rapid tolerance to bupivacaine cardiotoxicity in rats. ( Gao, JL; Han, FF; Li, XX; Li, YL; Wang, XM; Zhang, DH; Zhang, HJ; Zhao, QL, 2016) |
| "To observe the effects of electroacupuncture (EA) pretreatment at different times for heart arrest induced by bupivacaine poisoning in rats." | 3.83 | [Effects of pretreatment of electroacupuncture on bupivacaine poisoning in rats]. ( Gao, J; Li, Y; Liu, Y; Wang, X; Yang, F; Zhao, Q, 2016) |
| "Asystole was induced by bupivacaine (10 mg/kg over 20 seconds, IV) in young male Sprague-Dawley rats, and resuscitation with LE (intralipid 20%; 5 mL/kg bolus and 0." | 3.81 | Involvement of Opioid Receptors in the Lipid Rescue of Bupivacaine-Induced Cardiotoxicity. ( Eghbali, M; Li, J; Partownavid, P; Rahman, S; Sharma, S; Umar, S, 2015) |
| " Asystole was induced with intravenous levobupivacaine injection." | 3.80 | Efficacy of resuscitation with Intralipid in a levobupivacaine-induced cardiac arrest model. ( Aydin, S; Aydoğan, A; Davarci, I; Karcioğlu, M; Özden, R; Sari, A; Sefil, F; Tuzcu, K, 2014) |
| "The reversal efficacy of 2% lipid emulsion in cardiac asystole induced by different concentrations of bupivacaine is poorly defined and needs to be determined." | 3.80 | Measurement of the efficacy of 2% lipid in reversing bupivacaine- induced asystole in isolated rat hearts. ( Chen, H; Chen, L; Hu, X; Papadimos, TJ; Wang, Q; Wang, W; Xia, Y; Xu, S; Xu, X; Zhu, B, 2014) |
| " The group 3 received fluid resuscitation plus levosimendan (3 µg/kg/min) 1 min after asystole and the group 4 received both levosimendan and lipid emulsion treatment." | 3.80 | The effect of levosimendan combined with 20% lipid emulsion treatment on survival from bupivacaine induced toxicity in experiment. ( Aksu, R; Bicer, C; Darcin, K; Gokahmetoglu, G; Ugur, F, 2014) |
| "Pretreatment with lipid emulsion extended the time until occurrence of asystole and decreased times to recovery in bupivacaine-induced cardiac toxicity but not in mepivacaine-induced cardiac toxicity compared with control." | 3.80 | Lipid emulsion pretreatment has different effects on mepivacaine and bupivacaine cardiac toxicity in an isolated rat heart model. ( Aumeier, C; Busse, H; Graf, BM; Gruber, M; Kasdorf, B; Wiese, CH; Zausig, YA; Zink, W, 2014) |
| "Asystole was achieved with a single dose of bupivacaine (10 mg/kg over 20 secs, intravenously) and 20% lipid emulsion infusion (5 mL/kg bolus, and 0." | 3.78 | Fatty-acid oxidation and calcium homeostasis are involved in the rescue of bupivacaine-induced cardiotoxicity by lipid emulsion in rats. ( Eghbali, M; Li, J; Partownavid, P; Rahman, S; Umar, S, 2012) |
| "Thirty-two rats were subjected to bupivacaine to induce asystole." | 3.78 | Association of sustained cardiovascular recovery with epinephrine in the delayed lipid-based resuscitation from cardiac arrest induced by bupivacaine overdose in rats. ( Hu, Z; Li, B; Ma, Z; Shen, Y; Yan, J, 2012) |
| " Bupivacaine 100 μmol/L was perfused until 3 minutes after asystole." | 3.78 | The comparative effects of lipid, epinephrine, and their combination in the reversal of bupivacaine-induced asystole in the isolated rat heart. ( Chen, Y; Liu, L; Shi, T; Small, RH; Wang, F; Wang, Q; Xia, Y; Xu, X, 2012) |
| "LCT emulsion may be superior to LCT/MCT emulsion in treating bupivacaine-related cardiotoxicity as it was associated with fewer recurrences of asystole after resuscitation and lower myocardial bupivacaine concentrations." | 3.77 | Lipid resuscitation of bupivacaine toxicity: long-chain triglyceride emulsion provides benefits over long- and medium-chain triglyceride emulsion. ( Chen, H; Ding, X; Dong, H; Dong, X; Jin, Z; Li, Z; Papadimos, TJ; Wang, X; Xia, F; Xia, Y; Xu, X, 2011) |
| " Next, during continuous intravenous infusion of equipotent doses of bupivacaine, dextromethorphan, and dextrorphan (n = 8 in each group), we observed the time to seizure, apnea, and complete cardiac arrest." | 3.77 | Systemic dextromethorphan and dextrorphan are less toxic in rats than bupivacaine at equianesthetic doses. ( Chen, YC; Chen, YW; Hung, CH; Liu, TY; Wang, JJ, 2011) |
| "The concentration-response and time-response relationships of lipid emulsions used to reverse bupivacaine-induced asystole are poorly defined." | 3.76 | Lipid emulsion reverses bupivacaine-induced asystole in isolated rat hearts: concentration-response and time-response relationships. ( Chen, L; Chen, Y; Liu, L; Papadimos, TJ; Shi, K; Shi, T; Wang, Q; Xia, Y; Xu, X, 2010) |
| "A child with cerebral palsy and carnitine deficiency developed ventricular arrhythmias with loss of cardiac output during elective surgery under general anaesthesia with concomitant epidural analgesia." | 3.76 | Lipid resuscitation in a carnitine deficient child following intravascular migration of an epidural catheter. ( Joo, DT; McDonnell, C; Wong, GK, 2010) |
| "Twenty sedated, instrumented New Zealand White rabbits received 10 mg/kg IV bupivacaine producing asystole." | 3.76 | Epinephrine injection in lipid-based resuscitation from bupivacaine-induced cardiac arrest: transient circulatory return in rabbits. ( Cave, G; Harvey, M; Lahner, D; Prince, G, 2010) |
| "Instrumented rats were given an intravenous bolus of 20 mg/kg bupivacaine to induce asystole (zero time)." | 3.75 | Lipid emulsion is superior to vasopressin in a rodent model of resuscitation from toxin-induced cardiac arrest. ( Di Gregorio, G; Feinstein, DL; Kelly, K; Massad, M; Minshall, RD; Ori, C; Ripper, R; Schwartz, D; Weinberg, GL, 2009) |
| "Accidental intravascular administration of bupivacaine during performance of a brachial block precipitated convulsions followed by asystole." | 3.75 | Recurrence of cardiotoxicity after lipid rescue from bupivacaine-induced cardiac arrest. ( Coetzee, AR; Levin, AI; Marwick, PC, 2009) |
| " In 20 sedated, mechanically ventilated, and invasively monitored New Zealand White rabbits, asystole was induced via bolus bupivacaine injection." | 3.75 | Evaluation of the Association of Anaesthetists of Great Britain and Ireland lipid infusion protocol in bupivacaine induced cardiac arrest in rabbits. ( Cave, G; Harvey, MG; Winterbottom, T, 2009) |
| "We describe the case of a 9-yr-old child with undiagnosed long QT syndrome who experienced an intraoperative cardiac arrest after accidental intravascular injection of bupivacaine with epinephrine via a misplaced epidural catheter." | 3.72 | Unusual presentation of long QT syndrome. ( Cucchiaro, G; Rhodes, LA, 2003) |
| " Fifteen minutes later, each group was randomly subdivided into two equal groups and an infusion of bupivacaine or ropivacaine, 3 mg kg(-1) min(-1), was given until cardiac arrest (asystole) occurred." | 3.72 | Effects of clonidine pre-treatment on bupivacaine and ropivacaine cardiotoxicity in rats. ( Aydin, Y; Gulec, S; Senturk, Y; Uzuner, K; Yelken, B, 2004) |
| "75% bupivacaine hydrochloride at a rate of 10 ml x kg x min(-1) to asystole." | 3.70 | Pretreatment or resuscitation with a lipid infusion shifts the dose-response to bupivacaine-induced asystole in rats. ( Cwik, MJ; Garcia-Amaro, MF; Ramaraju, GA; VadeBoncouer, T; Weinberg, GL, 1998) |
| "The objective of this study was to compare the success of resuscitation attempts with different cardioactive drugs after bupivacaine-induced asystole." | 3.69 | Resuscitation from bupivacaine-induced asystole in rats: comparison of different cardioactive drugs. ( Heavner, JE; Pitkänen, MT; Rosenberg, PH; Shi, B, 1995) |
| "Toxic systemic reactions to bupivacaine usually involve a number of factors, including hypoxia and acidosis." | 3.68 | Severe hypoxia enhances central nervous system and cardiovascular toxicity of bupivacaine in lightly anesthetized pigs. ( Badgwell, JM; Bessire, A; Dryden, CF; Heavner, JE; Huemer, G; Sanghani, V, 1992) |
| " Future areas of investigation will focus on improved treatment regimes and better understanding of the mechanism of lipid rescue, which might allow superior alternative therapies, or treatment of other toxic events." | 2.43 | Lipid rescue resuscitation from local anaesthetic cardiac toxicity. ( Weinberg, G, 2006) |
| "Time of arrhythmia, 50% mean arterial pressure- and 50% heart rate-reduction, and asystole were recorded, and ropivacaine doses were calculated." | 1.72 | Effects of nalbuphine on the cardiotoxicity of ropivacaine in rats. ( Huang, S; Jiao, J; Sun, S; Wang, C; Yu, X, 2022) |
| "Remifentanil is a selective, ultra-short-acting, µ-opioid receptor agonist opioid." | 1.48 | Effects of Remifentanil Pretreatment on Bupivacaine Cardiotoxicity in Rats. ( Ayoğlu, H; Pişkin, Ö, 2018) |
| "In levobupivacaine-induced cardiac arrest, heart rate and MAP values were higher in the lipid group than in the control group after starting resuscitation (P < ." | 1.46 | Recovery From Ropivacaine-Induced or Levobupivacaine-Induced Cardiac Arrest in Rats: Comparison of Lipid Emulsion Effects. ( Horiguchi, T; Kimura, T; Nishikawa, T; Yoshimoto, M, 2017) |
| "Levosimendan combined with epinephrine may be superior to either drug alone for lipid-based resuscitation in a rat model of bupivacaine-induced cardiac arrest." | 1.46 | Levosimendan combined with epinephrine improves rescue outcomes in a rat model of lipid-based resuscitation from bupivacaine-induced cardiac arrest. ( Cai, X; Chen, L; Li, M; Li, Z; Nan, F; Xu, X; Ye, Y, 2017) |
| "We believe cardiac arrest may have been precipitated by local anesthetic systemic toxicity (LAST), and administration of i." | 1.43 | [A Case of Cardiac Arrest following Intra-articular Administration of Levobupivacaine during Total Knee Arthroplasty]. ( Kaji, A; Satani, M; Suzuki, K; Tomita, A; Urushitani, S, 2016) |
| "The optimal dosing regimens of lipid emulsion, epinephrine, or both are not yet determined in neonates in cases of local anaesthetic systemic toxicity (LAST)." | 1.40 | Resuscitation with lipid, epinephrine, or both in levobupivacaine-induced cardiac toxicity in newborn piglets. ( Allaouchiche, B; Cejka, JC; Chassard, D; de Queiroz Siqueira, M; Heilporn, A; Leveneur, O; Musard, H; Rhondali, O, 2014) |
| "Incident rates of cardiac arrest are reported as being from 0." | 1.38 | [Four cases of cardiac arrest during spinal anesthesia]. ( Imai, K; Kayashima, K; Kinoshita, Y; Yoshino, H, 2012) |
| "Bupivacaine was infused with a syringe driver via central venous catheter at a rate of 1 mg·kg(-1)·min(-1) until circulatory arrest." | 1.38 | Resuscitation strategies from bupivacaine-induced cardiac arrest. ( Bettschart-Wolfensberger, R; Jurado, OM; Mauch, J; Spielmann, N; Weiss, M, 2012) |
| "Bupivacaine was intravenously infused at a rate of 1, 4, or 16 mg/kg/min (groups A, B, and C, respectively) until mean arterial pressure (MAP) dropped to 50% of initial value." | 1.37 | Influence of bupivacaine injection dose rate on cardiovascular depression, subsequent hemodynamic course, and related bupivacaine plasma levels in piglets. ( Bettschart-Wolfensberger, R; Dave, MH; Kutter, AP; Martin Jurado, O; Mauch, J; Spielmann, N; Weiss, M, 2011) |
| " In this experiment, sedated rabbits were resuscitated from bupivacaine-induced asystole with intravenous lipid according to the Association of Anaesthetists of Great Britain and Ireland's guideline, or by identical lipid dosing with hypertonic saline: 6 mEq x kg(-1) 21% sodium chloride." | 1.36 | Effect of hypertonic saline on electrocardiography QRS duration in rabbit model of bupivacaine toxicity resuscitated by intravenous lipid. ( Cave, G; Desmet, J; Harvey, M; Lahner, D; Prince, G, 2010) |
| "In the isolated rat heart, cardiac arrest was induced by administration of equipotent doses of bupivacaine, ropivacaine, and mepivacaine, respectively, followed by cardiac perfusion with or without lipid emulsion (0." | 1.35 | Lipid emulsion improves recovery from bupivacaine-induced cardiac arrest, but not from ropivacaine- or mepivacaine-induced cardiac arrest. ( Barwing, J; Graf, BM; Keil, M; Sinner, B; Wiese, CH; Zausig, YA; Zink, W, 2009) |
| "We report a case of cardiac arrest after lumbar plexus block using a combination of 0." | 1.35 | Successful but prolonged resuscitation after local anesthetic-induced cardiac arrest: is clonidine effective? ( Bernard-Bertrand, F; Braque, S; Canciani, JP; Gentili, ME; Guezennec, D; Guillou, N, 2008) |
| "In this model of a bupivacaine-induced cardiac arrest, the vasopressor combination of vasopressin and epinephrine compared with lipid emulsion resulted in higher coronary perfusion pressure during CPR and survival rates." | 1.35 | A comparison of the combination of epinephrine and vasopressin with lipid emulsion in a porcine model of asphyxial cardiac arrest after intravenous injection of bupivacaine. ( Gritsch, C; Lindner, KH; Luckner, G; Mayr, VD; Mitterschiffthaler, L; Müller, T; Neurauter, A; Strohmenger, HU; Wenzel, V, 2008) |
| "Bupivacaine is a long-acting local anesthetic agent that is very widely used for cutaneous infiltration, peripheral nerve blocks, epidural anesthesia, and spinal anesthesia." | 1.33 | Cardiovascular collapse from low dose bupivacaine. ( Levsky, ME; Miller, MA, 2005) |
| "Women with severe postpartum hemorrhage, with or without DIC, should be considered for uterine artery embolization." | 1.32 | Two cases of hemorrhage secondary to amniotic fluid embolus managed with uterine artery embolization. ( Davies, S; Goldszmidt, E, 2003) |
| "In this model of bupivacaine-induced cardiac arrest, CPR with a combination of vasopressin and epinephrine resulted in significantly better survival rates than in the placebo group." | 1.32 | A comparison of epinephrine and vasopressin in a porcine model of cardiac arrest after rapid intravenous injection of bupivacaine. ( Lindner, KH; Mayr, VD; Raedler, C; Strohmenger, HU; Wenzel, V, 2004) |
| "The case of cardiopulmonary arrest we report is rare in the literature." | 1.31 | [Cardiorespiratory arrest: a rare complication of subdural block]. ( Bermejo, S; Escolano, F; Montes, A; Sánchez, JC; Silva Costa-Gomes, T, 2002) |
| "The doses of bupivacaine inducing seizure and ventricular tachycardia were significantly higher for liposomal bupivacaine than for the two plain solutions." | 1.29 | Toxicity of bupivacaine encapsulated into liposomes and injected intravenously: comparison with plain solutions. ( Akodad, EM; Benameur, H; Boogaerts, J; Declercq, A; Dupont, JC; Lafont, N; Legros, FJ, 1993) |
| " This work suggests that the lethal cardiorespiratory toxicity of lidocaine and bupivacaine associated with intravenous infusion is additively toxic in rats." | 1.28 | Lidocaine and bupivacaine cardiorespiratory toxicity is additive: a study in rats. ( Erskine, R; James, MF; Janicki, PK; Mets, B; Sasman, B, 1992) |
| "Bupivacaine was infused at a constant rate while the pigs' ECGs and EEGs were recorded." | 1.28 | Bupivacaine toxicity in young pigs is age-dependent and is affected by volatile anesthetics. ( Badgwell, JM; Heavner, JE; Kytta, J, 1990) |
| "To determine what effect the addition of epinephrine has on bupivacaine toxicity, toxic doses of bupivacaine were administered to awake spontaneously breathing pigs." | 1.28 | Effect of epinephrine on central nervous system and cardiovascular system toxicity of bupivacaine in pigs. ( Bernards, CM; Brown, DL; Carpenter, RL; Kenter, ME; Rupp, SM; Thompson, GE, 1989) |
| " Onset of electrical seizure activity occurred at about the same time in both groups and was defined as the central nervous system (CNS) toxic end point." | 1.27 | Toxicity and resuscitation in lidocaine- or bupivacaine-infused cats. ( Chadwick, HS, 1985) |
| "A 61-year-old woman experienced a cardiopulmonary arrest immediately after the retrobulbar injection of a mixture of 2 ml of 0." | 1.26 | Cardiopulmonary arrest after retrobular block. ( Barsoumian, K; May, DR; Rosenblatt, RM, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (11.67) | 18.7374 |
| 1990's | 21 (17.50) | 18.2507 |
| 2000's | 33 (27.50) | 29.6817 |
| 2010's | 49 (40.83) | 24.3611 |
| 2020's | 3 (2.50) | 2.80 |
| Authors | Studies |
|---|---|
| Viderman, D | 1 |
| Ben-David, B | 1 |
| Sarria-Santamera, A | 1 |
| Wang, C | 1 |
| Sun, S | 1 |
| Jiao, J | 1 |
| Yu, X | 1 |
| Huang, S | 1 |
| Kim, HJ | 1 |
| Kim, HS | 2 |
| Jung, JR | 2 |
| Kim, HY | 1 |
| Lynch, C | 2 |
| Park, WK | 2 |
| Kim, SH | 1 |
| Min, NH | 1 |
| Pişkin, Ö | 1 |
| Ayoğlu, H | 1 |
| Yoshimoto, M | 1 |
| Horiguchi, T | 1 |
| Kimura, T | 1 |
| Nishikawa, T | 1 |
| Nan, F | 1 |
| Cai, X | 2 |
| Ye, Y | 1 |
| Xu, X | 7 |
| Li, Z | 2 |
| Li, M | 1 |
| Chen, L | 4 |
| Gao, J | 1 |
| Li, Y | 1 |
| Wang, X | 2 |
| Zhao, Q | 1 |
| Liu, Y | 1 |
| Yang, F | 1 |
| Liu, L | 4 |
| Jin, Z | 3 |
| Xia, Y | 6 |
| Zhang, M | 1 |
| Papadimos, TJ | 5 |
| Shi, K | 3 |
| Chen, H | 3 |
| Xia, F | 2 |
| Zeballos, JL | 1 |
| Strichartz, GR | 1 |
| Oda, Y | 1 |
| Ikeda, Y | 1 |
| de Queiroz Siqueira, M | 1 |
| Chassard, D | 1 |
| Musard, H | 1 |
| Heilporn, A | 1 |
| Cejka, JC | 1 |
| Leveneur, O | 1 |
| Allaouchiche, B | 1 |
| Rhondali, O | 1 |
| Adachi, YU | 1 |
| Numaguchi, A | 1 |
| Matsuda, N | 1 |
| Aumeier, C | 1 |
| Kasdorf, B | 1 |
| Gruber, M | 1 |
| Busse, H | 1 |
| Wiese, CH | 2 |
| Zink, W | 3 |
| Graf, BM | 3 |
| Zausig, YA | 3 |
| Tucker, GT | 1 |
| Fettiplace, MR | 1 |
| Akpa, BS | 2 |
| Ripper, R | 2 |
| Zider, B | 1 |
| Lang, J | 1 |
| Rubinstein, I | 1 |
| Weinberg, G | 7 |
| Harvey, M | 5 |
| Cave, G | 6 |
| Whiteman, DM | 1 |
| Kushins, SI | 1 |
| Gokahmetoglu, G | 1 |
| Aksu, R | 1 |
| Bicer, C | 1 |
| Darcin, K | 1 |
| Ugur, F | 1 |
| Zhu, B | 1 |
| Hu, X | 1 |
| Xu, S | 1 |
| Wang, W | 1 |
| Wang, Q | 3 |
| Karcioğlu, M | 1 |
| Tuzcu, K | 1 |
| Sefil, F | 1 |
| Davarci, I | 1 |
| Aydin, S | 1 |
| Sari, A | 1 |
| Aydoğan, A | 1 |
| Özden, R | 1 |
| Partownavid, P | 2 |
| Sharma, S | 1 |
| Li, J | 2 |
| Umar, S | 2 |
| Rahman, S | 2 |
| Eghbali, M | 2 |
| Busardò, FP | 1 |
| Tritapepe, L | 1 |
| Montana, A | 1 |
| Indorato, F | 1 |
| Zaami, S | 1 |
| Romano, G | 1 |
| Katowitz, WR | 1 |
| O'Brien, M | 1 |
| Kiskis, E | 1 |
| Elliott, EM | 1 |
| Tomita, A | 1 |
| Satani, M | 1 |
| Suzuki, K | 1 |
| Kaji, A | 1 |
| Urushitani, S | 1 |
| Gao, JL | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| U.S Guided Erector Spinae Block for Postoperative Pain Control in Patients Undergoing Para Umblical Hernial Repair. (Comparative Study ).[NCT06120088] | 300 participants (Anticipated) | Observational | 2023-12-01 | Not yet recruiting | |||
| An Investigation Into the Effects of Intravenous Lipid Emulsion (ILE) on the Pharmacokinetic and Pharmacodynamic Properties of Metoprolol.[NCT02924454] | Phase 4 | 10 participants (Actual) | Interventional | 2016-09-30 | Completed | ||
| The Immune Response of Breast Cancer Patients Treated With Levobupivacaine Using Paravertebral or Superficial Chest Blocks[NCT05816538] | 100 participants (Anticipated) | Interventional | 2023-04-30 | Not yet recruiting | |||
| Postoperative Management of Obstructive Sleep Apnea With CPAP vs. an Autoadjusting CPAP Device: a Randomized Controlled Single Center Trial[NCT00588848] | 11 participants (Actual) | Interventional | 2008-01-31 | Terminated (stopped due to Difficulty with enrollment) | |||
| The Effect of Acute Intravenous Morphine Administration on Sleep Disordered Breathing (SDB) in Patients With Moderate Obstructive Sleep Apnoea (OSA): A Paired Design Trial[NCT03127800] | Phase 3 | 6 participants (Actual) | Interventional | 2016-05-20 | Terminated (stopped due to Difficulties with recruitment) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Events are defined as apneas and hypopneas. AHI values are typically categorized as 5-14.9 events/hr = mild; 15-29.9 events/hr = moderate; and >= 30 events/hr = severe (NCT00588848)
Timeframe: On postoperative night number 1 from 2200 to 0600. Study participation will end within 72 hours of admission.
| Intervention | events per hour (Mean) |
|---|---|
| AUTOCPAP | 2.1 |
| CPAP | 1.2 |
Predefined cardiopulmonary complications: Myocardial Infarction, Arrhythmia, new onset Heart Failure, Stroke (NCT00588848)
Timeframe: 72 hours
| Intervention | Participants (Count of Participants) |
|---|---|
| Autoadjusting CPAP (VPAP Auto) | 0 |
| CPAP Arm (Usual Care) | 0 |
(NCT00588848)
Timeframe: On postoperative night number 1 from 2200 to 0600. Study participation will end within 72 hours of admission.
| Intervention | Percentage of time < 90% saturation (Mean) |
|---|---|
| AUTOCPAP | 10.5 |
| CPAP | 7.1 |
7 reviews available for bupivacaine and Heart Arrest
| Article | Year |
|---|---|
Analysis of bupivacaine and ropivacaine-related cardiac arrests in regional anesthesia: A systematic review of case reports.
Topics: Anesthesia, Conduction; Anesthetics, Local; Bupivacaine; Heart Arrest; Humans; Ropivacaine | 2021 |
Lipid infusion rescue for bupivacaine-induced cardiac arrest after axillary block.
Topics: Adolescent; Anesthetics, Local; Axilla; Bupivacaine; Fat Emulsions, Intravenous; Female; Heart Arres | 2010 |
Lipid resuscitation: a life-saving antidote for local anesthetic toxicity.
Topics: Anesthesia, Conduction; Anesthetics, Local; Animals; Bupivacaine; Disease Models, Animal; Fat Emulsi | 2011 |
[Systemic toxicity of local anesthetics and its clinical management].
Topics: Anesthetics, Local; Animals; Bupivacaine; Delayed-Action Preparations; Drug Design; Emulsions; Heart | 2008 |
Emergent cardiopulmonary bypass for bupivacaine cardiotoxicity.
Topics: Adult; Anesthetics, Local; Ankle; Arthroplasty; Bupivacaine; Cardiopulmonary Bypass; Emergency Treat | 2003 |
Lipid rescue resuscitation from local anaesthetic cardiac toxicity.
Topics: Anesthetics, Local; Animals; Bupivacaine; Disease Models, Animal; Etidocaine; Fat Emulsions, Intrave | 2006 |
Three sudden postoperative respiratory arrests associated with epidural opioids in patients with sleep apnea.
Topics: Adult; Aged; Analgesia, Epidural; Analgesics, Opioid; Apnea; Blood Pressure; Bupivacaine; Female; Fe | 1997 |
Three sudden postoperative respiratory arrests associated with epidural opioids in patients with sleep apnea.
Topics: Adult; Aged; Analgesia, Epidural; Analgesics, Opioid; Apnea; Blood Pressure; Bupivacaine; Female; Fe | 1997 |
Three sudden postoperative respiratory arrests associated with epidural opioids in patients with sleep apnea.
Topics: Adult; Aged; Analgesia, Epidural; Analgesics, Opioid; Apnea; Blood Pressure; Bupivacaine; Female; Fe | 1997 |
Three sudden postoperative respiratory arrests associated with epidural opioids in patients with sleep apnea.
Topics: Adult; Aged; Analgesia, Epidural; Analgesics, Opioid; Apnea; Blood Pressure; Bupivacaine; Female; Fe | 1997 |
113 other studies available for bupivacaine and Heart Arrest
| Article | Year |
|---|---|
Effects of nalbuphine on the cardiotoxicity of ropivacaine in rats.
Topics: Amides; Anesthetics, Local; Animals; Arrhythmias, Cardiac; Bupivacaine; Cardiotoxicity; Heart Arrest | 2022 |
Lipid Emulsion Restoration of Myocardial Contractions After Bupivacaine-Induced Asystole In Vitro: A Benefit of Long- and Medium-Chain Triglyceride Over Long-Chain Triglyceride.
Topics: Anesthetics, Local; Animals; Bupivacaine; Cardiotoxicity; Drug Compounding; Energy Metabolism; Fat E | 2020 |
Intralipid Restoration of Myocardial Contractions Following Bupivacaine-Induced Asystole: Concentration- and Time-Dependence In Vitro.
Topics: Anesthetics, Local; Animals; Blood Pressure; Bupivacaine; Emulsions; Fat Emulsions, Intravenous; Gly | 2017 |
Effects of Remifentanil Pretreatment on Bupivacaine Cardiotoxicity in Rats.
Topics: Anesthetics, Local; Animals; Antidotes; Arrhythmias, Cardiac; Arterial Pressure; Bupivacaine; Cardio | 2018 |
Recovery From Ropivacaine-Induced or Levobupivacaine-Induced Cardiac Arrest in Rats: Comparison of Lipid Emulsion Effects.
Topics: Amides; Anesthetics, Local; Animals; Arterial Pressure; Biomarkers; Bupivacaine; Carbon Dioxide; Car | 2017 |
Levosimendan combined with epinephrine improves rescue outcomes in a rat model of lipid-based resuscitation from bupivacaine-induced cardiac arrest.
Topics: Anesthetics, Local; Animals; Anti-Arrhythmia Agents; Bupivacaine; Cardiopulmonary Resuscitation; Dru | 2017 |
[Effects of pretreatment of electroacupuncture on bupivacaine poisoning in rats].
Topics: Acupuncture Points; Anesthetics, Local; Animals; Arterial Pressure; Bupivacaine; Electroacupuncture; | 2016 |
Comparative Regimens of Lipid Rescue From Bupivacaine-Induced Asystole in a Rat Model.
Topics: Anesthetics, Local; Animals; Bupivacaine; Disease Models, Animal; Fat Emulsions, Intravenous; Heart | 2019 |
Levosimendan is superior to epinephrine on coronary flow for lipid-base resuscitation of bupivacaine-induced asystole in the isolated rat heart.
Topics: Anesthetics, Local; Animals; Blood Flow Velocity; Bupivacaine; Coronary Circulation; Drug Therapy, C | 2018 |
Tuning Up the Life Saver: An Experimental Approach to Optimizing the Delivery of Intravenous Lipid Emulsions.
Topics: Animals; Bupivacaine; Emulsions; Fat Emulsions, Intravenous; Heart Arrest; Lipids; Rats | 2019 |
Effect of lipid emulsion on the central nervous system and cardiac toxicity of bupivacaine and levobupivacaine in awake rats.
Topics: Anesthetics, Local; Animals; Bupivacaine; Central Nervous System; Fat Emulsions, Intravenous; Heart | 2013 |
Resuscitation with lipid, epinephrine, or both in levobupivacaine-induced cardiac toxicity in newborn piglets.
Topics: Anesthetics, Local; Animals; Animals, Newborn; Bupivacaine; Cardiopulmonary Resuscitation; Dose-Resp | 2014 |
Not only bupivacaine but also propofol is sinking in lipid?
Topics: Animals; Bupivacaine; Central Nervous System; Fat Emulsions, Intravenous; Heart Arrest; Male; Wakefu | 2014 |
Lipid emulsion pretreatment has different effects on mepivacaine and bupivacaine cardiac toxicity in an isolated rat heart model.
Topics: Anesthetics, Local; Animals; Bupivacaine; Drug Administration Schedule; Fat Emulsions, Intravenous; | 2014 |
Physiologically based pharmacokinetic-pharmacodynamic modeling to the rescue: understanding how resuscitation from local anesthetic overdose with lipid emulsions works.
Topics: Animals; Bupivacaine; Cardiotonic Agents; Fat Emulsions, Intravenous; Heart Arrest; Male; Resuscitat | 2014 |
Resuscitation with lipid emulsion: dose-dependent recovery from cardiac pharmacotoxicity requires a cardiotonic effect.
Topics: Anesthetics, Local; Animals; Bupivacaine; Cardiotonic Agents; Disease Models, Animal; Dose-Response | 2014 |
Lipid rescue: does the sink hold water? And other controversies.
Topics: Anesthetics, Local; Animals; Bupivacaine; Emulsions; Epinephrine; Fat Emulsions, Intravenous; Female | 2014 |
Successful Resuscitation With Intralipid After Marcaine Overdose.
Topics: Adult; Anesthetics, Local; Bupivacaine; Drug Overdose; Emulsions; Female; Heart Arrest; Humans; Infu | 2014 |
The effect of levosimendan combined with 20% lipid emulsion treatment on survival from bupivacaine induced toxicity in experiment.
Topics: Animals; Bupivacaine; Cardiopulmonary Resuscitation; Electrocardiography; Fat Emulsions, Intravenous | 2014 |
Measurement of the efficacy of 2% lipid in reversing bupivacaine- induced asystole in isolated rat hearts.
Topics: Anesthetics, Local; Animals; Bupivacaine; Dose-Response Relationship, Drug; Fat Emulsions, Intraveno | 2014 |
Efficacy of resuscitation with Intralipid in a levobupivacaine-induced cardiac arrest model.
Topics: Anesthetics, Local; Animals; Bupivacaine; Coronary Circulation; Disease Models, Animal; Drug Therapy | 2014 |
Involvement of Opioid Receptors in the Lipid Rescue of Bupivacaine-Induced Cardiotoxicity.
Topics: Anesthetics, Local; Animals; Bupivacaine; Disease Models, Animal; Dose-Response Relationship, Drug; | 2015 |
A fatal accidental subarachnoid injection of lidocaine and levobupivacaine during a lumbar paravertebral block.
Topics: Anesthetics, Local; Bupivacaine; Fatal Outcome; Female; Heart Arrest; Humans; Injections; Levobupiva | 2015 |
An asystolic event after eyelid skin bupivicaine injection during chalazion surgery.
Topics: Anesthesia, General; Anesthetics, Local; Bupivacaine; Chalazion; Child; Electrocardiography; Eyelids | 2016 |
[A Case of Cardiac Arrest following Intra-articular Administration of Levobupivacaine during Total Knee Arthroplasty].
Topics: Aged; Anesthetics, Local; Arthroplasty, Replacement, Knee; Bupivacaine; Epinephrine; Female; Heart A | 2016 |
Electroacupuncture pretreatment induces rapid tolerance to bupivacaine cardiotoxicity in rats.
Topics: Anesthetics, Local; Animals; Arrhythmias, Cardiac; Arterial Pressure; Blood Pressure; Bupivacaine; C | 2016 |
Successful but prolonged resuscitation after local anesthetic-induced cardiac arrest: is clonidine effective?
Topics: Adrenergic alpha-Agonists; Aged; Anesthetics, Local; Bupivacaine; Cardiopulmonary Resuscitation; Clo | 2008 |
Bupivacaine cardiotoxicity--hypercarbia is bad but hypocapnia may be worse.
Topics: Amides; Anesthesia, Conduction; Anesthetics, Local; Animals; Bupivacaine; Carbon Dioxide; Cardiotoxi | 2008 |
Lipid emulsion is superior to vasopressin in a rodent model of resuscitation from toxin-induced cardiac arrest.
Topics: Animals; Bupivacaine; Disease Models, Animal; Epinephrine; Fat Emulsions, Intravenous; Heart Arrest; | 2009 |
Recurrence of cardiotoxicity after lipid rescue from bupivacaine-induced cardiac arrest.
Topics: Adult; Amiodarone; Anesthetics, Local; Anti-Arrhythmia Agents; Brachial Plexus; Bupivacaine; Cardiop | 2009 |
Lipid emulsion combined with epinephrine and vasopressin does not improve survival in a swine model of bupivacaine-induced cardiac arrest.
Topics: Animals; Bupivacaine; Disease Models, Animal; Drug Therapy, Combination; Epinephrine; Fat Emulsions, | 2009 |
Evaluation of the Association of Anaesthetists of Great Britain and Ireland lipid infusion protocol in bupivacaine induced cardiac arrest in rabbits.
Topics: Anesthetics, Local; Animals; Bupivacaine; Clinical Protocols; Disease Models, Animal; Electrocardiog | 2009 |
Bupivacaine-induced cardiac arrest: fat is good-is epinephrine really bad?
Topics: Anesthetics, Local; Bupivacaine; Epinephrine; Fat Emulsions, Intravenous; Heart Arrest; Hemodynamics | 2009 |
Lipid emulsion improves recovery from bupivacaine-induced cardiac arrest, but not from ropivacaine- or mepivacaine-induced cardiac arrest.
Topics: Amides; Anesthetics, Local; Animals; Antidotes; Bupivacaine; Fat Emulsions, Intravenous; Heart Arres | 2009 |
Lipid resuscitation in a carnitine deficient child following intravascular migration of an epidural catheter.
Topics: Analgesia, Epidural; Anesthetics, Local; Bupivacaine; Carnitine; Cerebral Palsy; Child; Fat Emulsion | 2010 |
Is it "lipid sink," hemodilution, or both?
Topics: Anesthetics, Local; Animals; Bupivacaine; Combined Modality Therapy; Dose-Response Relationship, Dru | 2009 |
Anesthetic effects and lipid resuscitation protocols.
Topics: Anesthetics; Anesthetics, Local; Animals; Bupivacaine; Disease Models, Animal; Dogs; Epinephrine; Fa | 2010 |
Thirty years after the bupivacaine controversy: what have we learned?
Topics: Anesthetics, Local; Bupivacaine; Heart Arrest; Humans | 2010 |
Lipid emulsion and recovery from local anesthetic-induced "cardiac arrest": misleading interpretations.
Topics: Anesthesia Recovery Period; Anesthetics, Local; Animals; Bupivacaine; Coronary Circulation; Data Int | 2010 |
Effect of hypertonic saline on electrocardiography QRS duration in rabbit model of bupivacaine toxicity resuscitated by intravenous lipid.
Topics: Anesthetics, Local; Animals; Blood Pressure; Bupivacaine; Coronary Circulation; Disease Models, Anim | 2010 |
Epinephrine injection in lipid-based resuscitation from bupivacaine-induced cardiac arrest: transient circulatory return in rabbits.
Topics: Anesthetics, Local; Animals; Blood Gas Analysis; Blood Pressure; Bupivacaine; Coronary Circulation; | 2010 |
Successful resuscitation after inadvertent intravenous injection of bupivacaine in an adolescent.
Topics: Adolescent; Anesthetics, Local; Bupivacaine; Cardiopulmonary Resuscitation; Cleft Lip; Cleft Palate; | 2010 |
Systemic dextromethorphan and dextrorphan are less toxic in rats than bupivacaine at equianesthetic doses.
Topics: Anesthetics, Local; Animals; Apnea; Bupivacaine; Dextromethorphan; Dextrorphan; Dose-Response Relati | 2011 |
Lipid emulsion reverses bupivacaine-induced asystole in isolated rat hearts: concentration-response and time-response relationships.
Topics: Algorithms; Anesthetics, Local; Animals; Blood Pressure; Bupivacaine; Dose-Response Relationship, Dr | 2010 |
Successful resuscitation from bupivacaine-induced cardiovascular collapse with intravenous lipid emulsion following femoral nerve block in an emergency department.
Topics: Aged; Anesthetics, Local; Bupivacaine; Emergency Service, Hospital; Fat Emulsions, Intravenous; Fema | 2011 |
The comparative effects of lipid, epinephrine, and their combination in the reversal of bupivacaine-induced asystole in the isolated rat heart.
Topics: Anesthetics, Local; Animals; Bupivacaine; Coronary Circulation; Electrocardiography; Epinephrine; Fa | 2012 |
Influence of bupivacaine injection dose rate on cardiovascular depression, subsequent hemodynamic course, and related bupivacaine plasma levels in piglets.
Topics: Anesthetics, Local; Animals; Blood Pressure; Bupivacaine; Cardiovascular System; Depression, Chemica | 2011 |
Fatality involving complications of bupivacaine toxicity and hypersensitivity reaction.
Topics: Adult; Anesthetics, Local; Atrial Septum; Bradycardia; Bupivacaine; Cardiomegaly; Drug Hypersensitiv | 2011 |
Resuscitation strategies from bupivacaine-induced cardiac arrest.
Topics: Anesthetics, Local; Animals; Blood Gas Analysis; Blood Pressure; Bupivacaine; Cardiopulmonary Resusc | 2012 |
Lipid resuscitation of bupivacaine toxicity: long-chain triglyceride emulsion provides benefits over long- and medium-chain triglyceride emulsion.
Topics: Analysis of Variance; Anesthetics, Local; Animals; Bronchodilator Agents; Bupivacaine; Disease Model | 2011 |
Association of sustained cardiovascular recovery with epinephrine in the delayed lipid-based resuscitation from cardiac arrest induced by bupivacaine overdose in rats.
Topics: Anesthetics, Local; Animals; Bupivacaine; Combined Modality Therapy; Disease Models, Animal; Drug Ad | 2012 |
Lipid resuscitation: listening to our patients and learning from our models.
Topics: Amides; Anesthetics, Local; Animals; Antipsychotic Agents; Benzodiazepines; Bupivacaine; Epinephrine | 2012 |
Commentary on: Dudley MH, Fleming SW, Garg U, Edwards JM. Fatality involving complications of bupivacaine toxicity and hypersensitivity reaction. J Forensic Sci 2011;56(5):1376-9.
Topics: Anesthetics, Local; Bupivacaine; Drug Hypersensitivity; Heart Arrest; Humans; Male | 2012 |
Commentary on: Dudley MH, Fleming SW, Garg U, Edwards JM. Fatality involving complications of bupivacaine toxicity and hypersensitivity reaction. J Forensic Sci 2011;56(5):1376-9.
Topics: Anesthetics, Local; Bupivacaine; Drug Hypersensitivity; Heart Arrest; Humans; Male | 2012 |
Fatty-acid oxidation and calcium homeostasis are involved in the rescue of bupivacaine-induced cardiotoxicity by lipid emulsion in rats.
Topics: Animals; Bupivacaine; Calcium; Fat Emulsions, Intravenous; Fatty Acids; Heart Arrest; Heart Massage; | 2012 |
Lipid resuscitation: more than a sink.
Topics: Animals; Bupivacaine; Calcium; Fat Emulsions, Intravenous; Fatty Acids; Heart Arrest; Homeostasis; M | 2012 |
Hyperamylasemia following lipid resuscitation: pancreas or parotid?
Topics: Anesthetics, Local; Bupivacaine; Cardiopulmonary Resuscitation; Fat Emulsions, Intravenous; Heart Ar | 2012 |
[Four cases of cardiac arrest during spinal anesthesia].
Topics: Adult; Anesthesia, Epidural; Anesthesia, Spinal; Atropine; Blood Volume; Bupivacaine; Heart Arrest; | 2012 |
Was case report a case of unrecognized local anesthetic toxicity?
Topics: Adrenergic beta-Antagonists; Adult; Anesthetics, Local; Bupivacaine; Female; Heart Arrest; Humans; L | 2003 |
Unusual presentation of long QT syndrome.
Topics: Anesthetics, Local; Bupivacaine; Child; Epinephrine; Heart Arrest; Humans; Intraoperative Complicati | 2003 |
The relative toxicity of amitriptyline, bupivacaine, and levobupivacaine administered as rapid infusions in rats.
Topics: Amitriptyline; Anesthetics, Local; Animals; Antidepressive Agents, Tricyclic; Blood Pressure; Bupiva | 2003 |
Two cases of hemorrhage secondary to amniotic fluid embolus managed with uterine artery embolization.
Topics: Adult; Amides; Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthetics, | 2003 |
Effects of clonidine pre-treatment on bupivacaine and ropivacaine cardiotoxicity in rats.
Topics: Adrenergic alpha-Agonists; Amides; Anesthetics, Local; Animals; Arrhythmias, Cardiac; Blood Pressure | 2004 |
A comparison of epinephrine and vasopressin in a porcine model of cardiac arrest after rapid intravenous injection of bupivacaine.
Topics: Anesthetics, Local; Animals; Bupivacaine; Cardiac Output; Drug Combinations; Epilepsy, Tonic-Clonic; | 2004 |
Lipid emulsion to treat bupivacaine toxicity.
Topics: Anesthetics, Local; Animals; Bupivacaine; Dogs; Fat Emulsions, Intravenous; Heart Arrest; Humans | 2005 |
Cardiovascular collapse from low dose bupivacaine.
Topics: Aged; Anesthetics, Local; Bupivacaine; Catheter Ablation; Dose-Response Relationship, Drug; Electroc | 2005 |
Successful use of a 20% lipid emulsion to resuscitate a patient after a presumed bupivacaine-related cardiac arrest.
Topics: Bupivacaine; Fat Emulsions, Intravenous; Heart Arrest; Humans; Male; Middle Aged; Resuscitation | 2006 |
In defence of lipid resuscitation.
Topics: Anesthetics, Local; Animals; Bupivacaine; Dogs; Fat Emulsions, Intravenous; Heart Arrest; Humans | 2006 |
Lipid emulsion for bupivacaine toxicity: too soon to celebrate?
Topics: Anesthetics, Local; Bupivacaine; Fat Emulsions, Intravenous; Heart Arrest; Humans; Male; Middle Aged | 2007 |
Lipid infusion for cardiotoxicity: promise? Yes-panacea? Not.
Topics: Anesthesia, Local; Bupivacaine; Fat Emulsions, Intravenous; Heart Arrest; Humans; Resuscitation | 2007 |
Advanced cardiac life support for presumed bupivacaine-related cardiac arrest.
Topics: Advanced Cardiac Life Support; Anesthetics, Local; Brachial Plexus; Bupivacaine; Heart Arrest; Human | 2007 |
Lipid rescue from bupivacaine cardiac arrest: a result of failure to ventilate and maintain cardiac perfusion?
Topics: Aged, 80 and over; Amides; Anesthetics, Local; Bupivacaine; Coronary Circulation; Fat Emulsions, Int | 2007 |
Levobupivacaine-induced seizures and cardiovascular collapse treated with Intralipid.
Topics: Aged; Anesthetics, Local; Bupivacaine; Fat Emulsions, Intravenous; Female; Heart Arrest; Humans; Int | 2007 |
The hemodynamic effects of insulin following overdosage with levobupivacaine or racemic bupivacaine in dogs.
Topics: Anesthetics, Local; Animals; Blood Flow Velocity; Blood Pressure; Bupivacaine; Cardiac Output; Cardi | 2007 |
Ventricular standstill: a complication of intrapleural anesthesia using bupivacaine in a patient with free transverse rectus abdominus myocutaneous flap breast reconstruction.
Topics: Anesthesia, Local; Anesthetics, Local; Bradycardia; Breast Neoplasms; Bupivacaine; Carcinoma, Intrad | 2007 |
A comparison of the combination of epinephrine and vasopressin with lipid emulsion in a porcine model of asphyxial cardiac arrest after intravenous injection of bupivacaine.
Topics: Anesthetics, Local; Animals; Asphyxia; Bupivacaine; Cardiopulmonary Resuscitation; Coronary Circulat | 2008 |
Intravenous lipid infusion in the successful resuscitation of local anesthetic-induced cardiovascular collapse after supraclavicular brachial plexus block.
Topics: Anesthetics, Local; Brachial Plexus; Bupivacaine; Cardiopulmonary Resuscitation; Electrocardiography | 2008 |
Simulation education in anesthesia training: a case report of successful resuscitation of bupivacaine-induced cardiac arrest linked to recent simulation training.
Topics: Advanced Cardiac Life Support; Aged, 80 and over; Anesthesiology; Anesthetics, Local; Bupivacaine; C | 2008 |
[Wrong dosage caused drop in blood pressure and circulatory failure].
Topics: Aged; Bupivacaine; Heart Arrest; Humans; Male; Medication Errors; Nursing Staff, Hospital; Sweden | 1983 |
Adverse reactions with bupivacaine.
Topics: Bupivacaine; Heart Arrest; Humans | 1983 |
Cardiotoxicity of local anesthetics--the plot thickens.
Topics: Anesthesia, Obstetrical; Anesthetics, Local; Animals; Bupivacaine; Etidocaine; Female; Heart Arrest; | 1984 |
Possible role of epinephrine in prevention or correction of myocardial depression associated with bupivacaine.
Topics: Adult; Aged; Anesthesia, Local; Anesthesia, Obstetrical; Bupivacaine; Epinephrine; Female; Heart; He | 1983 |
Cardiopulmonary resuscitation of late-pregnant women.
Topics: Anesthesia, Epidural; Bupivacaine; Delivery, Obstetric; Female; Heart Arrest; Humans; Infant, Newbor | 1982 |
Intravenous bupivacaine anesthesia.
Topics: Anesthesia, Intravenous; Bupivacaine; Heart Arrest; Humans | 1982 |
Cardiopulmonary arrest after retrobular block.
Topics: Anesthetics, Local; Bupivacaine; Drug Combinations; Female; Heart Arrest; Humans; Hyaluronoglucosami | 1980 |
Cardiopulmonary arrest after retrobulbar anesthesia in a patient with an orbital roof defect.
Topics: Aged; Anesthesia, Local; Anesthetics, Local; Bupivacaine; Cardiopulmonary Resuscitation; Female; Hea | 1995 |
Regional anesthesia and local anesthetic-induced systemic toxicity: seizure frequency and accompanying cardiovascular changes.
Topics: Adult; Anesthesia, Caudal; Anesthesia, Epidural; Anesthetics; Anesthetics, Local; Blood Pressure; Br | 1995 |
Resuscitation from bupivacaine-induced asystole in rats: comparison of different cardioactive drugs.
Topics: Amrinone; Animals; Blood Pressure; Bupivacaine; Cardiotonic Agents; Dopamine; Electrocardiography; E | 1995 |
Cardiorespiratory arrest following combined spinal epidural anaesthesia for caesarean section.
Topics: Adult; Anesthesia, Epidural; Anesthesia, Obstetrical; Anesthesia, Spinal; Bupivacaine; Cardiopulmona | 1993 |
Ventricular tachycardia and brief cardiovascular collapse in two infants after caudal anesthesia using a bupivacaine-epinephrine solution.
Topics: Anesthesia, Caudal; Bupivacaine; Epinephrine; Female; Heart Arrest; Humans; Infant; Male; Tachycardi | 1993 |
Delayed asystole during spinal anaesthesia for transurethral resection of the prostate.
Topics: Aged; Aged, 80 and over; Anesthesia, Spinal; Bupivacaine; Heart Arrest; Humans; Male; Prostatectomy; | 1993 |
Toxicity of bupivacaine encapsulated into liposomes and injected intravenously: comparison with plain solutions.
Topics: Animals; Bupivacaine; Drug Carriers; Heart Arrest; Infusions, Intravenous; Liposomes; Rabbits; Seizu | 1993 |
Cardiac arrest following epidural overdose.
Topics: Analgesia, Epidural; Analgesics, Opioid; Anesthetics, Local; Bupivacaine; Female; Fentanyl; Heart Ar | 1995 |
Epidural anesthesia.
Topics: Aged; Anesthesia, Epidural; Anesthetics, Local; Bupivacaine; Coma; Embolism, Air; Female; Heart Arre | 1997 |
Cardiac arrest after caesarean section under subarachnoid block.
Topics: Anesthesia, Obstetrical; Anesthesia, Spinal; Anesthetics, Local; Bupivacaine; Cesarean Section; Fema | 1997 |
Pretreatment or resuscitation with a lipid infusion shifts the dose-response to bupivacaine-induced asystole in rats.
Topics: Anesthetics, Local; Animals; Bupivacaine; Chromatography, High Pressure Liquid; Dose-Response Relati | 1998 |
Third degree heart block and asystole associated with spinal anesthesia.
Topics: Aged; Anesthetics, Local; Arthroplasty, Replacement, Hip; Bupivacaine; Heart Arrest; Heart Block; Hu | 1998 |
[Cardiorespiratory arrest: a rare complication of subdural block].
Topics: Aged; Anesthesia, Epidural; Anesthetics, Local; Apnea; Arthroplasty, Replacement, Hip; Bradycardia; | 2002 |
Cardiac arrest following regional anesthesia with etidocaine or bupivacaine.
Topics: Acetanilides; Anesthesia, Conduction; Bupivacaine; Dose-Response Relationship, Drug; Etidocaine; Hea | 1979 |
Propranolol protection from bupivacaine toxicity.
Topics: Animals; Apnea; Bupivacaine; Calcium Channels; Heart Arrest; Propranolol; Rats; Rats, Inbred Strains | 1992 |
Lidocaine and bupivacaine cardiorespiratory toxicity is additive: a study in rats.
Topics: Animals; Bupivacaine; Drug Synergism; Heart Arrest; Infusions, Intravenous; Lidocaine; Male; Rats; R | 1992 |
Morbidity and mortality with outpatient anesthesia: the Massachusetts experience.
Topics: Aged; Ambulatory Surgical Procedures; Anesthesia, Dental; Anesthesia, General; Anesthesia, Intraveno | 1992 |
Severe hypoxia enhances central nervous system and cardiovascular toxicity of bupivacaine in lightly anesthetized pigs.
Topics: Anesthesia, Inhalation; Animals; Arrhythmias, Cardiac; Blood Pressure; Bupivacaine; Electroencephalo | 1992 |
[The association of continuous peridural anesthesia with general anesthesia. Apropos of 2 accidents].
Topics: Aged; Anesthesia, Epidural; Anesthesia, General; Blood Vessels; Bupivacaine; Female; Heart Arrest; H | 1991 |
Bupivacaine-induced cardiac arrest.
Topics: Brachial Plexus; Bupivacaine; Heart Arrest; Humans; Nerve Block | 1990 |
Bupivacaine-induced cardiac arrest.
Topics: Anesthetics, Local; Bupivacaine; Female; Heart Arrest; Humans | 1990 |
Bupivacaine toxicity in young pigs is age-dependent and is affected by volatile anesthetics.
Topics: Aging; Animals; Arrhythmias, Cardiac; Blood Pressure; Bupivacaine; Cardiac Output; Drug Interactions | 1990 |
Successful resuscitation of bupivacaine-induced cardiac arrest using cardiopulmonary bypass.
Topics: Adult; Bupivacaine; Cardiopulmonary Bypass; Female; Hand Injuries; Heart Arrest; Humans; Intraoperat | 1989 |
The use of continuous spinal anesthesia in severe tetanus with autonomic disturbance.
Topics: Adult; Anesthesia, Spinal; Autonomic Nerve Block; Blood Pressure; Bupivacaine; Female; Heart Arrest; | 1989 |
Effect of epinephrine on central nervous system and cardiovascular system toxicity of bupivacaine in pigs.
Topics: Animals; Arrhythmias, Cardiac; Bupivacaine; Cardiovascular System; Central Nervous System; Dose-Resp | 1989 |
Successful resuscitation of a bupivacaine-induced cardiac arrest using cardiopulmonary bypass and mitral valve replacement.
Topics: Adult; Anesthesia, Epidural; Bupivacaine; Cardiopulmonary Bypass; Female; Heart Arrest; Heart Valve | 1987 |
Toxicity and resuscitation in lidocaine- or bupivacaine-infused cats.
Topics: Anesthesia, Inhalation; Animals; Blood Pressure; Bupivacaine; Cats; Electrocardiography; Electroence | 1985 |
Thoracic epidural in the management of chest trauma. A study of 161 cases.
Topics: Adolescent; Adult; Aged; Anesthesia, Epidural; Bupivacaine; Epinephrine; Female; Heart Arrest; Human | 1985 |