bupivacaine has been researched along with Genital Neoplasms, Female in 10 studies
Bupivacaine: A widely used local anesthetic agent.
1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide : A piperidinecarboxamide obtained by formal condensation of the carboxy group of N-butylpipecolic acid with the amino group of 2,6-dimethylaniline.
bupivacaine : A racemate composed of equimolar amounts of dextrobupivacaine and levobupivacaine. Used (in the form of its hydrochloride hydrate) as a local anaesthetic.
Genital Neoplasms, Female: Tumor or cancer of the female reproductive tract (GENITALIA, FEMALE).
Excerpt | Relevance | Reference |
---|---|---|
"To investigate opioid use and pain scores associated with incisional injection of liposomal bupivacaine compared with bupivacaine hydrochloride after laparotomy for gynecologic malignancies." | 3.83 | Abdominal Incision Injection of Liposomal Bupivacaine and Opioid Use After Laparotomy for Gynecologic Malignancies. ( Bakkum-Gamez, JN; Borah, BJ; Cliby, WA; Dowdy, SC; Jankowski, CJ; Kalogera, E; Langstraat, CL; Lovely, JK; Moriarty, JP; Weaver, AL, 2016) |
"Secondary outcomes were postoperative pain satisfaction and oral narcotic requirements." | 3.11 | Laparoscopic guided liposomal bupivacaine injection compared to transversus abdominus plane block for postoperative pain after robotic gynecologic oncology surgery. ( Betcher, R; Black, D; Fontenot, AC; McDonald, V; Patel, A; Scoggin, S; Wang, Y, 2022) |
"Fentanyl utilisation was significantly lower in group FB (median 41 versus 53 micrograms/hr, P < 0." | 2.67 | Postoperative epidural fentanyl infusion--is the addition of 0.1% bupivacaine of benefit? ( Paech, MJ; Westmore, MD, 1994) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 1 (10.00) | 18.7374 |
1990's | 1 (10.00) | 18.2507 |
2000's | 2 (20.00) | 29.6817 |
2010's | 4 (40.00) | 24.3611 |
2020's | 2 (20.00) | 2.80 |
Authors | Studies |
---|---|
McDonald, V | 1 |
Wang, Y | 1 |
Patel, A | 1 |
Betcher, R | 1 |
Fontenot, AC | 1 |
Scoggin, S | 1 |
Black, D | 1 |
Bernard, L | 1 |
Lavecchia, M | 1 |
Trepanier, G | 1 |
Mah, S | 1 |
Pokoradi, A | 1 |
McGinnis, JM | 1 |
Alyafi, M | 1 |
Glezerson, B | 1 |
Nguyen, J | 1 |
Carlson, V | 1 |
Helpman, L | 1 |
Elit, L | 1 |
Jimenez, W | 1 |
Eiriksson, L | 1 |
Reade, CJ | 1 |
Finch, L | 1 |
Phillips, A | 1 |
Acheson, N | 1 |
Dix, P | 1 |
Berry, C | 1 |
El Hachem, L | 1 |
Small, E | 1 |
Chung, P | 1 |
Moshier, EL | 1 |
Friedman, K | 1 |
Fenske, SS | 1 |
Gretz, HF | 1 |
Hotujec, BT | 1 |
Spencer, RJ | 1 |
Donnelly, MJ | 1 |
Bruggink, SM | 1 |
Rose, SL | 1 |
Al-Niaimi, A | 1 |
Chappell, R | 1 |
Stewart, SL | 1 |
Kushner, DM | 1 |
Kalogera, E | 1 |
Bakkum-Gamez, JN | 1 |
Weaver, AL | 1 |
Moriarty, JP | 1 |
Borah, BJ | 1 |
Langstraat, CL | 1 |
Jankowski, CJ | 1 |
Lovely, JK | 1 |
Cliby, WA | 1 |
Dowdy, SC | 1 |
Shen-Gunther, J | 1 |
Vincenti, E | 1 |
Chiaranda, M | 1 |
Ambrosini, A | 1 |
Becagli, L | 1 |
De Salvia, D | 1 |
Maggino, T | 1 |
Marchesoni, D | 1 |
Paech, MJ | 1 |
Westmore, MD | 1 |
Vallejo, MC | 1 |
Edwards, RP | 1 |
Shannon, KT | 1 |
Kaul, B | 1 |
Finegold, H | 1 |
Morrison, HL | 1 |
Ramanathan, S | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Analgesic Efficacy of Transversus Abdominis Plane Block Versus Local Injection in Postoperative Pain Management Following Minimally Invasive Gynecological Surgery[NCT02314104] | 220 participants (Actual) | Interventional | 2011-05-31 | Completed | |||
A Randomized, Controlled, Observer-blinded Pilot Trial of Laparoscopic Large Volume, Multisite Transversus Abdominal Plane (TAP) Block With Liposomal Bupivacaine in Patients Undergoing Minimally Invasive Hysterectomy for Endometrial Cancer[NCT05763667] | Phase 3 | 15 participants (Anticipated) | Interventional | 2023-12-01 | Not yet recruiting | ||
Postoperative Analgesia After Cardiac Surgery - A Double-Blind, Prospective and Randomized Comparison of Wound Infiltration With Liposomal Bupivacaine and Bupivacaine Hydrochloride[NCT03270514] | Phase 3 | 60 participants (Actual) | Interventional | 2018-11-15 | Completed | ||
The Effect of Local Infiltration of Liposomal Bupivacaine on Opioid Consumption at Time of Cesarean Delivery: A Randomized Controlled Trial[NCT03907813] | Phase 4 | 0 participants (Actual) | Interventional | 2019-05-01 | Withdrawn (stopped due to change in design) | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
A Visual Analogue Scale was used. The scale range was 0 to 10 in increments of one. 0 was no pain and 10 was worst pain possible. (NCT02314104)
Timeframe: one hour postoperatively
Intervention | units on a scale (Mean) |
---|---|
Treatment TAP, Placebo Local Injection | 4.04 |
Placebo TAP, Treatment Local Injection | 5.09 |
Treatment TAP, Treatment Local Injection | 4.4 |
A Visual Analogue Scale was used. The scale range was 0 to 10 in increments of one. 0 was no pain and 10 was worst pain possible. (NCT02314104)
Timeframe: six hours postoperatively
Intervention | units on a scale (Mean) |
---|---|
Treatment TAP, Placebo Local Injection | 3.53 |
Placebo TAP, Treatment Local Injection | 3.5 |
Treatment TAP, Treatment Local Injection | 3.33 |
A Visual Analogue Scale was used. The scale range was 0 to 10 in increments of one. 0 was no pain and 10 was worst pain possible. (NCT02314104)
Timeframe: twenty-four hours postoperatively
Intervention | units on a scale (Mean) |
---|---|
Treatment TAP, Placebo Local Injection | 3.36 |
Placebo TAP, Treatment Local Injection | 3.56 |
Treatment TAP, Treatment Local Injection | 3.51 |
(NCT02314104)
Timeframe: up to twenty-four hours postoperatively
Intervention | minutes (Median) |
---|---|
Treatment TAP, Placebo Local Injection | 46 |
Placebo TAP, Treatment Local Injection | 31 |
Treatment TAP, Treatment Local Injection | 28 |
(NCT02314104)
Timeframe: up to twenty-four hours postoperatively
Intervention | mg (Mean) |
---|---|
Treatment TAP, Placebo Local Injection | 20.09 |
Placebo TAP, Treatment Local Injection | 23.14 |
Treatment TAP, Treatment Local Injection | 20.68 |
Readmission to hospital will be noted (NCT03270514)
Timeframe: From end of surgery assessed up to 30 days post-operatively
Intervention | Participants (Count of Participants) |
---|---|
Exparel Injectable Product | 3 |
Bupivacaine Hydrochloride | 3 |
Mortality will be noted at specific timepoints (NCT03270514)
Timeframe: From end of surgery assessed up to 30 days post-operatively
Intervention | Participants (Count of Participants) |
---|---|
Exparel Injectable Product | 0 |
Bupivacaine Hydrochloride | 1 |
Episodes of NIV such as upper airway masks or similar devices will be quantified (NCT03270514)
Timeframe: From time of end of surgery to 72 hours post-operatively or until hospital discharge
Intervention | Participants (Count of Participants) |
---|---|
Exparel Injectable Product | 6 |
Bupivacaine Hydrochloride | 5 |
Patient will give an assessment regarding pain management on a scale of 0 - 10 with 0 indicating the lowest satisfaction with pain management and 10 indicating the highest satisfaction with pain management (NCT03270514)
Timeframe: Given at the time of discharge up to 30 days post-operatively
Intervention | score on a scale (Median) |
---|---|
Exparel Injectable Product | 10 |
Bupivacaine Hydrochloride | 10 |
The time it takes until patient ambulates will be measured (NCT03270514)
Timeframe: From time of end of surgery to time of mobilization up to 72 hours or discharge, *assessed up to 120 hours*
Intervention | hours (Median) |
---|---|
Exparel Injectable Product | 42 |
Bupivacaine Hydrochloride | 45 |
The time it takes until the patient is able to/medically cleared to consume food or liquid will be measured (NCT03270514)
Timeframe: From time of end of surgery to time of oral intake up to 72 hours post-operatively or until hospital discharge
Intervention | hours (Median) |
---|---|
Exparel Injectable Product | 7 |
Bupivacaine Hydrochloride | 5.6 |
The time it takes until the patient advances from bedrest to out of bed (OOB) to chair will be measured (NCT03270514)
Timeframe: From time of end of surgery to time of mobilization up to 72 hours post-operatively
Intervention | hours (Median) |
---|---|
Exparel Injectable Product | 16 |
Bupivacaine Hydrochloride | 16 |
Whether a patient experiences at least one episode of nausea and emesis will be measured (NCT03270514)
Timeframe: From time of end of surgery to 72 hours post-operatively
Intervention | Participants (Count of Participants) |
---|---|
Exparel Injectable Product | 3 |
Bupivacaine Hydrochloride | 9 |
Instances of re-intubation will be recorded (NCT03270514)
Timeframe: From time of end of surgery to patient discharge up to one week
Intervention | Participants (Count of Participants) |
---|---|
Exparel Injectable Product | 3 |
Bupivacaine Hydrochloride | 3 |
The time it takes until the patient is extubated post-operatively will be measured (NCT03270514)
Timeframe: From the end of surgery until the patient is extubated up to 72 hours post-operatively
Intervention | hours (Median) |
---|---|
Exparel Injectable Product | 3.85 |
Bupivacaine Hydrochloride | 3.47 |
Frequency of incentive spirometry will be measured (NCT03270514)
Timeframe: From time of end of surgery to 72 hours post-operatively
Intervention | Participants (Count of Participants) |
---|---|
Exparel Injectable Product | 29 |
Bupivacaine Hydrochloride | 31 |
Length of both hospital and ICU stay will be measured (NCT03270514)
Timeframe: From date of surgery assessed up to 30 day post-operatively
Intervention | days (Median) | |
---|---|---|
Length of ICU stay | Length of postoperative hospital stay | |
Bupivacaine Hydrochloride | 1.71 | 6 |
Exparel Injectable Product | 1.51 | 7 |
Postoperative pain scores evaluated by numeric rating scale or (NRS) where 0- no pain and 10- worst pain, at rest and at movement (NCT03270514)
Timeframe: NRS scores will be evaluated every 4 hours until 24 hours post-operatively, every 8 hours until 48 hours post-operatively, and every 12 hours for 72 hours post-operatively
Intervention | score on a scale (Mean) | |||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
4hrs. at rest | 4hrs. with movement | 8hrs. at rest | 8hrs. with movement | 12hrs. at rest | 12hrs. with movement | 16hrs. at rest | 16hrs. with movement | 20hrs. at rest | 20hrs. with movement | 24hrs. at rest | 24hrs. with movement | 32hrs. at rest | 32hrs. with movement | 40hrs. at rest | 40hrs. with movement | 48hrs. at rest | 48hrs. with movement | 60hrs. at rest | 60hrs. with movement | 72hrs. at rest | 72hrs. with movement | |
Bupivacaine Hydrochloride | 5.03 | 6.64 | 4.996 | 6.6 | 4.962 | 6.56 | 4.928 | 6.52 | 4.894 | 6.48 | 4.86 | 6.44 | 4.792 | 6.32 | 4.724 | 6.24 | 4.656 | 6.16 | 4.554 | 6.04 | 4.452 | 5.92 |
Exparel Injectable Product | 4.7482 | 5.75 | 4.7262 | 5.74 | 4.7042 | 5.73 | 4.6822 | 5.72 | 4.6602 | 5.71 | 4.6382 | 5.7 | 4.5942 | 5.68 | 4.5282 | 5.66 | 4.4622 | 5.64 | 4.3742 | 5.61 | 4.2862 | 5.58 |
Stress response suppression as a result of treatment will be evaluated by comparing hormone levels between the groups. Serum cortisol levels will be taken to measure this. (NCT03270514)
Timeframe: Measured 8, 48, and 72 hours post-operatively
Intervention | µg/dL (Median) | ||
---|---|---|---|
8 hours postoperatively | 48 hours postoperatively | 72 hours postoperatively | |
Bupivacaine Hydrochloride | 36.5 | 19 | 17 |
Exparel Injectable Product | 30 | 15 | 16 |
All narcotics administered in the first 0-8, 8-24, 24-48, and 48-72 hours and the total narcotics administered in the 0-72 hours postoperative period(PCA narcotics, nurse-administered IV narcotics, and oral narcotics). All narcotics will be converted to total IV morphine equivalent for comparison between two groups. (NCT03270514)
Timeframe: 0-72 hours post-operative period
Intervention | oral morphine equivalents in mg (Median) | ||||
---|---|---|---|---|---|
0-8 hours | 8-24 hours | 24-48 hours | 48-72 hours | 0-72 hours | |
Bupivacaine Hydrochloride | 10 | 34.5 | 45 | 26.5 | 105 |
Exparel Injectable Product | 15 | 45 | 45 | 15 | 139 |
6 trials available for bupivacaine and Genital Neoplasms, Female
Article | Year |
---|---|
Laparoscopic guided liposomal bupivacaine injection compared to transversus abdominus plane block for postoperative pain after robotic gynecologic oncology surgery.
Topics: Abdominal Muscles; Analgesics, Opioid; Anesthetics, Local; Bupivacaine; Female; Genital Neoplasms, F | 2022 |
A double-blinded, randomized trial comparing surgeon-administered transversus abdominis plane block with placebo after midline laparotomy in gynecologic oncology surgery.
Topics: Abdominal Muscles; Analgesics, Opioid; Anesthetics, Local; Bupivacaine; Canada; Double-Blind Method; | 2023 |
Randomized controlled double-blind trial of transversus abdominis plane block versus trocar site infiltration in gynecologic laparoscopy.
Topics: Abdominal Muscles; Adult; Aged; Anesthesia, Local; Anesthetics, Local; Bupivacaine; Cohort Studies; | 2015 |
Transversus abdominis plane block in robotic gynecologic oncology: a randomized, placebo-controlled trial.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Anesthetics, Local; Bupivacaine; Dou | 2015 |
Postoperative epidural fentanyl infusion--is the addition of 0.1% bupivacaine of benefit?
Topics: Abdominal Neoplasms; Adult; Aged; Analgesia, Epidural; Bupivacaine; Dizziness; Double-Blind Method; | 1994 |
Improved bowel function after gynecological surgery with epidural bupivacaine-fentanyl than bupivacaine-morphine infusion.
Topics: Adult; Aged; Analgesia, Epidural; Bupivacaine; Digestive System; Female; Fentanyl; Genital Neoplasms | 2000 |
4 other studies available for bupivacaine and Genital Neoplasms, Female
Article | Year |
---|---|
An evaluation of the effects of a service change from epidurals to rectus sheath catheters on postoperative pain.
Topics: Anesthesia, Conduction; Anesthetics, Local; Bupivacaine; Catheterization; Catheters; Female; Genital | 2013 |
Abdominal Incision Injection of Liposomal Bupivacaine and Opioid Use After Laparotomy for Gynecologic Malignancies.
Topics: Administration, Oral; Analgesia, Patient-Controlled; Analgesics, Opioid; Bupivacaine; Cohort Studies | 2016 |
Abdominal Incision Injection of Liposomal Bupivacaine and Opioid Use After Laparotomy for Gynecologic Malignancies.
Topics: Administration, Oral; Analgesia, Patient-Controlled; Analgesics, Opioid; Bupivacaine; Cohort Studies | 2016 |
Abdominal Incision Injection of Liposomal Bupivacaine and Opioid Use After Laparotomy for Gynecologic Malignancies.
Topics: Administration, Oral; Analgesia, Patient-Controlled; Analgesics, Opioid; Bupivacaine; Cohort Studies | 2016 |
Abdominal Incision Injection of Liposomal Bupivacaine and Opioid Use After Laparotomy for Gynecologic Malignancies.
Topics: Administration, Oral; Analgesia, Patient-Controlled; Analgesics, Opioid; Bupivacaine; Cohort Studies | 2016 |
ON-Q anesthetic pump in gynecologic oncology: feasibility study of a novel placement technique at an army hospital.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anesthetics, Local; Bupivacaine; Feasibility Studies; Fe | 2008 |
New trends for pain relief in gynaecologic oncology.
Topics: Autonomic Nerve Block; Bupivacaine; Celiac Plexus; Epidural Space; Female; Genital Neoplasms, Female | 1983 |