Page last updated: 2024-10-24

bupivacaine and Genital Neoplasms, Female

bupivacaine has been researched along with Genital Neoplasms, Female in 10 studies

Bupivacaine: A widely used local anesthetic agent.
1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide : A piperidinecarboxamide obtained by formal condensation of the carboxy group of N-butylpipecolic acid with the amino group of 2,6-dimethylaniline.
bupivacaine : A racemate composed of equimolar amounts of dextrobupivacaine and levobupivacaine. Used (in the form of its hydrochloride hydrate) as a local anaesthetic.

Genital Neoplasms, Female: Tumor or cancer of the female reproductive tract (GENITALIA, FEMALE).

Research Excerpts

ExcerptRelevanceReference
"To investigate opioid use and pain scores associated with incisional injection of liposomal bupivacaine compared with bupivacaine hydrochloride after laparotomy for gynecologic malignancies."3.83Abdominal Incision Injection of Liposomal Bupivacaine and Opioid Use After Laparotomy for Gynecologic Malignancies. ( Bakkum-Gamez, JN; Borah, BJ; Cliby, WA; Dowdy, SC; Jankowski, CJ; Kalogera, E; Langstraat, CL; Lovely, JK; Moriarty, JP; Weaver, AL, 2016)
"Secondary outcomes were postoperative pain satisfaction and oral narcotic requirements."3.11Laparoscopic guided liposomal bupivacaine injection compared to transversus abdominus plane block for postoperative pain after robotic gynecologic oncology surgery. ( Betcher, R; Black, D; Fontenot, AC; McDonald, V; Patel, A; Scoggin, S; Wang, Y, 2022)
"Fentanyl utilisation was significantly lower in group FB (median 41 versus 53 micrograms/hr, P < 0."2.67Postoperative epidural fentanyl infusion--is the addition of 0.1% bupivacaine of benefit? ( Paech, MJ; Westmore, MD, 1994)

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19901 (10.00)18.7374
1990's1 (10.00)18.2507
2000's2 (20.00)29.6817
2010's4 (40.00)24.3611
2020's2 (20.00)2.80

Authors

AuthorsStudies
McDonald, V1
Wang, Y1
Patel, A1
Betcher, R1
Fontenot, AC1
Scoggin, S1
Black, D1
Bernard, L1
Lavecchia, M1
Trepanier, G1
Mah, S1
Pokoradi, A1
McGinnis, JM1
Alyafi, M1
Glezerson, B1
Nguyen, J1
Carlson, V1
Helpman, L1
Elit, L1
Jimenez, W1
Eiriksson, L1
Reade, CJ1
Finch, L1
Phillips, A1
Acheson, N1
Dix, P1
Berry, C1
El Hachem, L1
Small, E1
Chung, P1
Moshier, EL1
Friedman, K1
Fenske, SS1
Gretz, HF1
Hotujec, BT1
Spencer, RJ1
Donnelly, MJ1
Bruggink, SM1
Rose, SL1
Al-Niaimi, A1
Chappell, R1
Stewart, SL1
Kushner, DM1
Kalogera, E1
Bakkum-Gamez, JN1
Weaver, AL1
Moriarty, JP1
Borah, BJ1
Langstraat, CL1
Jankowski, CJ1
Lovely, JK1
Cliby, WA1
Dowdy, SC1
Shen-Gunther, J1
Vincenti, E1
Chiaranda, M1
Ambrosini, A1
Becagli, L1
De Salvia, D1
Maggino, T1
Marchesoni, D1
Paech, MJ1
Westmore, MD1
Vallejo, MC1
Edwards, RP1
Shannon, KT1
Kaul, B1
Finegold, H1
Morrison, HL1
Ramanathan, S1

Clinical Trials (4)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Analgesic Efficacy of Transversus Abdominis Plane Block Versus Local Injection in Postoperative Pain Management Following Minimally Invasive Gynecological Surgery[NCT02314104]220 participants (Actual)Interventional2011-05-31Completed
A Randomized, Controlled, Observer-blinded Pilot Trial of Laparoscopic Large Volume, Multisite Transversus Abdominal Plane (TAP) Block With Liposomal Bupivacaine in Patients Undergoing Minimally Invasive Hysterectomy for Endometrial Cancer[NCT05763667]Phase 315 participants (Anticipated)Interventional2023-12-01Not yet recruiting
Postoperative Analgesia After Cardiac Surgery - A Double-Blind, Prospective and Randomized Comparison of Wound Infiltration With Liposomal Bupivacaine and Bupivacaine Hydrochloride[NCT03270514]Phase 360 participants (Actual)Interventional2018-11-15Completed
The Effect of Local Infiltration of Liposomal Bupivacaine on Opioid Consumption at Time of Cesarean Delivery: A Randomized Controlled Trial[NCT03907813]Phase 40 participants (Actual)Interventional2019-05-01Withdrawn (stopped due to change in design)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Postoperative Pain on a Visual Analogue Pain Scale at One Hour Postoperatively

A Visual Analogue Scale was used. The scale range was 0 to 10 in increments of one. 0 was no pain and 10 was worst pain possible. (NCT02314104)
Timeframe: one hour postoperatively

Interventionunits on a scale (Mean)
Treatment TAP, Placebo Local Injection4.04
Placebo TAP, Treatment Local Injection5.09
Treatment TAP, Treatment Local Injection4.4

Postoperative Pain on a Visual Analogue Pain Scale at Six Hours Postoperatively

A Visual Analogue Scale was used. The scale range was 0 to 10 in increments of one. 0 was no pain and 10 was worst pain possible. (NCT02314104)
Timeframe: six hours postoperatively

Interventionunits on a scale (Mean)
Treatment TAP, Placebo Local Injection3.53
Placebo TAP, Treatment Local Injection3.5
Treatment TAP, Treatment Local Injection3.33

Postoperative Pain on a Visual Analogue Pain Scale at Twenty-four Hours Postoperatively

A Visual Analogue Scale was used. The scale range was 0 to 10 in increments of one. 0 was no pain and 10 was worst pain possible. (NCT02314104)
Timeframe: twenty-four hours postoperatively

Interventionunits on a scale (Mean)
Treatment TAP, Placebo Local Injection3.36
Placebo TAP, Treatment Local Injection3.56
Treatment TAP, Treatment Local Injection3.51

Time Until First Request for Pain Medication

(NCT02314104)
Timeframe: up to twenty-four hours postoperatively

Interventionminutes (Median)
Treatment TAP, Placebo Local Injection46
Placebo TAP, Treatment Local Injection31
Treatment TAP, Treatment Local Injection28

Total Narcotic Usage in Morphine Equivalents

(NCT02314104)
Timeframe: up to twenty-four hours postoperatively

Interventionmg (Mean)
Treatment TAP, Placebo Local Injection20.09
Placebo TAP, Treatment Local Injection23.14
Treatment TAP, Treatment Local Injection20.68

Hospital Readmission

Readmission to hospital will be noted (NCT03270514)
Timeframe: From end of surgery assessed up to 30 days post-operatively

InterventionParticipants (Count of Participants)
Exparel Injectable Product3
Bupivacaine Hydrochloride3

Mortality

Mortality will be noted at specific timepoints (NCT03270514)
Timeframe: From end of surgery assessed up to 30 days post-operatively

InterventionParticipants (Count of Participants)
Exparel Injectable Product0
Bupivacaine Hydrochloride1

Non-invasive Ventilation (NIV) Requirement

Episodes of NIV such as upper airway masks or similar devices will be quantified (NCT03270514)
Timeframe: From time of end of surgery to 72 hours post-operatively or until hospital discharge

InterventionParticipants (Count of Participants)
Exparel Injectable Product6
Bupivacaine Hydrochloride5

Patient Satisfaction

Patient will give an assessment regarding pain management on a scale of 0 - 10 with 0 indicating the lowest satisfaction with pain management and 10 indicating the highest satisfaction with pain management (NCT03270514)
Timeframe: Given at the time of discharge up to 30 days post-operatively

Interventionscore on a scale (Median)
Exparel Injectable Product10
Bupivacaine Hydrochloride10

Patient Time to Mobilization

The time it takes until patient ambulates will be measured (NCT03270514)
Timeframe: From time of end of surgery to time of mobilization up to 72 hours or discharge, *assessed up to 120 hours*

Interventionhours (Median)
Exparel Injectable Product42
Bupivacaine Hydrochloride45

Patient Time to Oral Intake

The time it takes until the patient is able to/medically cleared to consume food or liquid will be measured (NCT03270514)
Timeframe: From time of end of surgery to time of oral intake up to 72 hours post-operatively or until hospital discharge

Interventionhours (Median)
Exparel Injectable Product7
Bupivacaine Hydrochloride5.6

Patient Time to Out of Bed to Chair

The time it takes until the patient advances from bedrest to out of bed (OOB) to chair will be measured (NCT03270514)
Timeframe: From time of end of surgery to time of mobilization up to 72 hours post-operatively

Interventionhours (Median)
Exparel Injectable Product16
Bupivacaine Hydrochloride16

Post-operative Nausea and Vomiting

Whether a patient experiences at least one episode of nausea and emesis will be measured (NCT03270514)
Timeframe: From time of end of surgery to 72 hours post-operatively

InterventionParticipants (Count of Participants)
Exparel Injectable Product3
Bupivacaine Hydrochloride9

Re-intubation

Instances of re-intubation will be recorded (NCT03270514)
Timeframe: From time of end of surgery to patient discharge up to one week

InterventionParticipants (Count of Participants)
Exparel Injectable Product3
Bupivacaine Hydrochloride3

Time to Extubation

The time it takes until the patient is extubated post-operatively will be measured (NCT03270514)
Timeframe: From the end of surgery until the patient is extubated up to 72 hours post-operatively

Interventionhours (Median)
Exparel Injectable Product3.85
Bupivacaine Hydrochloride3.47

Use of Incentive Spirometry

Frequency of incentive spirometry will be measured (NCT03270514)
Timeframe: From time of end of surgery to 72 hours post-operatively

InterventionParticipants (Count of Participants)
Exparel Injectable Product29
Bupivacaine Hydrochloride31

Length of Hospital and ICU Stay

Length of both hospital and ICU stay will be measured (NCT03270514)
Timeframe: From date of surgery assessed up to 30 day post-operatively

,
Interventiondays (Median)
Length of ICU stayLength of postoperative hospital stay
Bupivacaine Hydrochloride1.716
Exparel Injectable Product1.517

Post-operative Pain Intensity

Postoperative pain scores evaluated by numeric rating scale or (NRS) where 0- no pain and 10- worst pain, at rest and at movement (NCT03270514)
Timeframe: NRS scores will be evaluated every 4 hours until 24 hours post-operatively, every 8 hours until 48 hours post-operatively, and every 12 hours for 72 hours post-operatively

,
Interventionscore on a scale (Mean)
4hrs. at rest4hrs. with movement8hrs. at rest8hrs. with movement12hrs. at rest12hrs. with movement16hrs. at rest16hrs. with movement20hrs. at rest20hrs. with movement24hrs. at rest24hrs. with movement32hrs. at rest32hrs. with movement40hrs. at rest40hrs. with movement48hrs. at rest48hrs. with movement60hrs. at rest60hrs. with movement72hrs. at rest72hrs. with movement
Bupivacaine Hydrochloride5.036.644.9966.64.9626.564.9286.524.8946.484.866.444.7926.324.7246.244.6566.164.5546.044.4525.92
Exparel Injectable Product4.74825.754.72625.744.70425.734.68225.724.66025.714.63825.74.59425.684.52825.664.46225.644.37425.614.28625.58

Serum Cortisol Levels

Stress response suppression as a result of treatment will be evaluated by comparing hormone levels between the groups. Serum cortisol levels will be taken to measure this. (NCT03270514)
Timeframe: Measured 8, 48, and 72 hours post-operatively

,
Interventionµg/dL (Median)
8 hours postoperatively48 hours postoperatively72 hours postoperatively
Bupivacaine Hydrochloride36.51917
Exparel Injectable Product301516

Total Narcotic Consumption

All narcotics administered in the first 0-8, 8-24, 24-48, and 48-72 hours and the total narcotics administered in the 0-72 hours postoperative period(PCA narcotics, nurse-administered IV narcotics, and oral narcotics). All narcotics will be converted to total IV morphine equivalent for comparison between two groups. (NCT03270514)
Timeframe: 0-72 hours post-operative period

,
Interventionoral morphine equivalents in mg (Median)
0-8 hours8-24 hours24-48 hours48-72 hours0-72 hours
Bupivacaine Hydrochloride1034.54526.5105
Exparel Injectable Product15454515139

Trials

6 trials available for bupivacaine and Genital Neoplasms, Female

ArticleYear
Laparoscopic guided liposomal bupivacaine injection compared to transversus abdominus plane block for postoperative pain after robotic gynecologic oncology surgery.
    Gynecologic oncology, 2022, Volume: 166, Issue:3

    Topics: Abdominal Muscles; Analgesics, Opioid; Anesthetics, Local; Bupivacaine; Female; Genital Neoplasms, F

2022
A double-blinded, randomized trial comparing surgeon-administered transversus abdominis plane block with placebo after midline laparotomy in gynecologic oncology surgery.
    American journal of obstetrics and gynecology, 2023, Volume: 228, Issue:5

    Topics: Abdominal Muscles; Analgesics, Opioid; Anesthetics, Local; Bupivacaine; Canada; Double-Blind Method;

2023
Randomized controlled double-blind trial of transversus abdominis plane block versus trocar site infiltration in gynecologic laparoscopy.
    American journal of obstetrics and gynecology, 2015, Volume: 212, Issue:2

    Topics: Abdominal Muscles; Adult; Aged; Anesthesia, Local; Anesthetics, Local; Bupivacaine; Cohort Studies;

2015
Transversus abdominis plane block in robotic gynecologic oncology: a randomized, placebo-controlled trial.
    Gynecologic oncology, 2015, Volume: 136, Issue:3

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Anesthetics, Local; Bupivacaine; Dou

2015
Postoperative epidural fentanyl infusion--is the addition of 0.1% bupivacaine of benefit?
    Anaesthesia and intensive care, 1994, Volume: 22, Issue:1

    Topics: Abdominal Neoplasms; Adult; Aged; Analgesia, Epidural; Bupivacaine; Dizziness; Double-Blind Method;

1994
Improved bowel function after gynecological surgery with epidural bupivacaine-fentanyl than bupivacaine-morphine infusion.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2000, Volume: 47, Issue:5

    Topics: Adult; Aged; Analgesia, Epidural; Bupivacaine; Digestive System; Female; Fentanyl; Genital Neoplasms

2000

Other Studies

4 other studies available for bupivacaine and Genital Neoplasms, Female

ArticleYear
An evaluation of the effects of a service change from epidurals to rectus sheath catheters on postoperative pain.
    Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology, 2013, Volume: 33, Issue:5

    Topics: Anesthesia, Conduction; Anesthetics, Local; Bupivacaine; Catheterization; Catheters; Female; Genital

2013
Abdominal Incision Injection of Liposomal Bupivacaine and Opioid Use After Laparotomy for Gynecologic Malignancies.
    Obstetrics and gynecology, 2016, Volume: 128, Issue:5

    Topics: Administration, Oral; Analgesia, Patient-Controlled; Analgesics, Opioid; Bupivacaine; Cohort Studies

2016
Abdominal Incision Injection of Liposomal Bupivacaine and Opioid Use After Laparotomy for Gynecologic Malignancies.
    Obstetrics and gynecology, 2016, Volume: 128, Issue:5

    Topics: Administration, Oral; Analgesia, Patient-Controlled; Analgesics, Opioid; Bupivacaine; Cohort Studies

2016
Abdominal Incision Injection of Liposomal Bupivacaine and Opioid Use After Laparotomy for Gynecologic Malignancies.
    Obstetrics and gynecology, 2016, Volume: 128, Issue:5

    Topics: Administration, Oral; Analgesia, Patient-Controlled; Analgesics, Opioid; Bupivacaine; Cohort Studies

2016
Abdominal Incision Injection of Liposomal Bupivacaine and Opioid Use After Laparotomy for Gynecologic Malignancies.
    Obstetrics and gynecology, 2016, Volume: 128, Issue:5

    Topics: Administration, Oral; Analgesia, Patient-Controlled; Analgesics, Opioid; Bupivacaine; Cohort Studies

2016
ON-Q anesthetic pump in gynecologic oncology: feasibility study of a novel placement technique at an army hospital.
    Military medicine, 2008, Volume: 173, Issue:9

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anesthetics, Local; Bupivacaine; Feasibility Studies; Fe

2008
New trends for pain relief in gynaecologic oncology.
    European journal of gynaecological oncology, 1983, Volume: 4, Issue:2

    Topics: Autonomic Nerve Block; Bupivacaine; Celiac Plexus; Epidural Space; Female; Genital Neoplasms, Female

1983