Page last updated: 2024-10-24

bupivacaine and Epicondylitis, Lateral Humeral

bupivacaine has been researched along with Epicondylitis, Lateral Humeral in 4 studies

Bupivacaine: A widely used local anesthetic agent.
1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide : A piperidinecarboxamide obtained by formal condensation of the carboxy group of N-butylpipecolic acid with the amino group of 2,6-dimethylaniline.
bupivacaine : A racemate composed of equimolar amounts of dextrobupivacaine and levobupivacaine. Used (in the form of its hydrochloride hydrate) as a local anaesthetic.

Research Excerpts

ExcerptRelevanceReference
"In a prospective, randomized, double-blind study of radial epicondylalgia (tennis elbow), 109 patients with an average symptom duration of 8 months were considered for treatment with a single 1-mL injection of the steroid triamcinolone combined with either lidocaine or bupivacaine."5.08Cortisone injection with anesthetic additives for radial epicondylalgia (tennis elbow). ( Adalberth, G; Buch, F; Mallmin, H; Sölveborn, SA, 1995)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (25.00)18.2507
2000's2 (50.00)29.6817
2010's1 (25.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Behera, P1
Dhillon, M1
Aggarwal, S1
Marwaha, N1
Prakash, M1
Sölveborn, SA1
Buch, F1
Mallmin, H1
Adalberth, G1
Madan, S1
Jowett, RL1
Newcomer, KL1
Laskowski, ER1
Idank, DM1
McLean, TJ1
Egan, KS1

Clinical Trials (5)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Tennis Elbow, Randomized Study: Needling With and Without Platelet-rich Plasma After Failure of Up-to-date Rehabilitation[NCT03987256]58 participants (Anticipated)Interventional2020-01-01Recruiting
Safety and Effects of PDRN(Polydeoxyribonucleotide) Injection in Patient With Elbow Epicondylitis in Randomized Double-blind Active-control Comparative Study[NCT02492945]Phase 440 participants (Actual)Interventional2015-06-30Completed
Treatment of Tendon Injury Using Allogenic Adipose-derived Mesenchymal Stem Cells: Phase II Double-Blind Placebo-Controlled Randomized Clinical Trials.[NCT02298023]Phase 224 participants (Actual)Interventional2014-09-30Completed
Treatment of Tendon Injury Using Allogenic Adipose-derived Mesenchymal Stem Cells(ALLO-ASC):A Pilot Study[NCT01856140]Early Phase 112 participants (Actual)Interventional2013-05-31Completed
Treatment of Epicondylitis by Ultrasound-guided Local Injections of Autologous Conditioned Plasma (ACP®): a Double-blind Placebo-controlled Randomized Clinical Trial With One-year Follow-up[NCT02378285]50 participants (Actual)Interventional2010-10-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Change of Pain During Activity From Baseline to 3 Months After Intervention

Pain during activity will be evaluated by visual analog scale (active pain VAS). The active pain visual analog scale change from baseline to 3 months after intervention is the primary outcome. Visual analog scale is scored 0 to 10, higher scored meaning worse outcome. Negative values in change of pain during activity indicate improvement in pain. (NCT02298023)
Timeframe: Baseline and 3 months after intervention

Interventionunits on a scale (Mean)
Mesenchymal Stem Cell Group-1.4
Active Control (Fibrin Glue) Group-1.5
Control (Normal Saline )Group-3.0

American Shoulder and Elbow Surgeons (ASES) Shoulder Score

Functional score of the shoulder was assessed by American Shoulder and Elbow Surgeons shoulder score which is a questionnaire dedicated to the functional evaluation of the shoulder. It is scored from 0 to 100, higher scores meaning better outcome. (NCT02298023)
Timeframe: Baseline, 6 weeks, 12 weeks, 6, 12, 24 months after intervention

,,
Interventionscore on a scale (Mean)
baselineweek 6month 3month 6month 12year 2
Active Control (Fibrin Glue) Group64.770.673.776.776.080.0
Control (Normal Saline )Group54.765.963.663.974.489.3
Mesenchymal Stem Cell Group58.952.467.963.470.671.6

Disability of Arm, Shoulder and Hand (DASH) Score

Shoulder function is assessed by DASH score which is questionnaire dedicated to evaluate the function of the upper extremity. It is scored from 0 (no disability) to 100 (most severe disability). (NCT02298023)
Timeframe: Baseline, 6 weeks, 12 weeks, 6, 12, 24 months after intervention

,,
Interventionscore on a scale (Mean)
baselineweek 6month 3month 6month 12year 2
Active Control (Fibrin Glue) Group35.225.819.219.820.522.8
Control (Normal Saline )Group37.628.128.327.120.320.1
Mesenchymal Stem Cell Group32.336.724.025.031.120.3

Pain During Activity

Pain during activity assessed by visual analog scale (VAS), scored 0 to 10, higher scores meaning worse outcome (NCT02298023)
Timeframe: Baseline, 6 weeks, 12 weeks, 6, 12, 24 months after intervention

,,
Interventionunits on a scale (Mean)
baselineweek 6month 3month 6month 12year 2
Active Control (Fibrin Glue) Group4.73.23.22.83.23.2
Control (Normal Saline )Group6.64.63.64.33.11.1
Mesenchymal Stem Cell Group5.76.04.44.33.74.4

Pain During Rest

Pain during rest assessed by visual analog scale (VAS), scored 0 to 10, higher scores meaning worse outcome. (NCT02298023)
Timeframe: Baseline, 6 weeks, 12 weeks, 6, 12, 24 months after intervention

,,
Interventionunits on a scale (Mean)
baselineweek 6month 3month 6month 12year 2
Active Control (Fibrin Glue) Group2.42.21.91.41.80.8
Control (Normal Saline )Group3.63.02.72.41.30.5
Mesenchymal Stem Cell Group3.94.02.82.92.92.0

University of California, Los Angeles(UCLA) Shoulder Score

Shoulder function is assessed by UCLA shoulder score which is a composite of range of motion examination and questionnaire dedicated to evaluate the function of the shoulder. It is scored from 0 to 35, higher scores meaning better shoulder function. (NCT02298023)
Timeframe: Baseline, 6 weeks, 12 weeks, 6, 12, 24 months after intervention

,,
Interventionscore on a scale (Mean)
baselineweek 6month 3month 6month 12year 2
Active Control (Fibrin Glue) Group19.022.323.623.624.524.6
Control (Normal Saline )Group17.522.921.422.828.031.3
Mesenchymal Stem Cell Group20.320.026.422.723.624.4

Change From Baseline in Visual Analog Scale (VAS) at 6 and 12 Weeks

Self reported pain intensity during activity will be evaluated by visual analogue scale (0 = no pain, 10 = pain as bad as can be), higher scores meaning worse outcome. (NCT01856140)
Timeframe: Baseline, 6 weeks, 12 weeks after intervention

,
Interventionscore on a scale (Mean)
BaselinePost-injection 6 weeksPost-injection 12 weeks
1 Million Cells/ml of ALLO-ASC3.572.931.68
10 Million Cells/ml of ALLO-ASC3.021.600.87

Defect Area of Tendon by Ultrasonography in Long Axis

"Defect areas were measured as the largest defect of the common extensor tendon. Higher value means larger defect area.~With the patient supine position with the elbow in 30' flexion and full pronation, the cephalic end of the ultrasound transducer was placed on the lateral epicondyle and the long axis of the transducer was aligned with the long axis of radius. The alignment of the transducer and radius was achieved by visualizing contours of the bony structures. Multiple cross-sectional images were saved by shifting the transducer medio-laterally by 2mm at a time. Acquiring images were repeated three times.~Among the saved images, one image showing the largest defect were selected for every patients at every time points. Manual measurements of the defect area were conducted by tracking the perimeter using ImageJ 1.48 software (National Institutes of Health, http://imagej.nih.gov/ij/) and were repeated three times by two examiners in random orders and then, averaged." (NCT01856140)
Timeframe: Baseline, 6 weeks, and 12 weeks after the intervention

,
Interventionmm^2 (Mean)
BaselinePost-injection 6weeksPost-injection 12 weeks
1 Million Cells/ml of ALLO-ASC419741632381
10 Million Cells/ml of ALLO-ASC524643832516

Defect Area of Tendon by Ultrasonography in Short Axis

"Defect areas were measured as the largest defect of the common extensor tendon. Higher value means larger defect area.~With the patient supine position with the elbow in 30' flexion and full pronation, the transducer was placed on the proximal forearm just distal to the radial head, aligning the long axis of the transducer perpendicular to the long axis of the forearm. Viewing the round radius at the horizontal center, the transducer was shifted proximally by 2mm and multiple images were saved after the transducer passed the radial head until it slid over the prominence. Acquiring images were repeated three times.~Among the saved images, one image showing the largest defect were selected for every patients at every time points. Manual measurements of the defect area were conducted by tracking the perimeter using ImageJ 1.48 software (National Institutes of Health, http://imagej.nih.gov/ij/) and were repeated three times by two examiners in random orders and then, averaged." (NCT01856140)
Timeframe: Baseline, 6 weeks, and 12 weeks after the intervention

,
Interventionmm^2 (Mean)
BaselinePost-injection 6 weeksPost-injection 12 weeks
1 Million Cells/ml of ALLO-ASC372637972703
10 Million Cells/ml of ALLO-ASC501828492223

Modified Mayo Clinic Performance Index for the Elbow

The Modified Mayo clinic performance index for the elbow measures pain, motion, stability, and daily functions. (0 to 100) Higher score means better function. (NCT01856140)
Timeframe: Baseline, 6 weeks, 12 weeks after the intervention

,
Interventionscore on a scale (Median)
BaselinePost-injection 6 weeksPost-injection 12 weeks
1 Million Cells/ml of ALLO-ASC57.9283.7587.92
10 Million Cells/ml of ALLO-ASC70.0090.4191.67

Trials

3 trials available for bupivacaine and Epicondylitis, Lateral Humeral

ArticleYear
Leukocyte-poor platelet-rich plasma versus bupivacaine for recalcitrant lateral epicondylar tendinopathy.
    Journal of orthopaedic surgery (Hong Kong), 2015, Volume: 23, Issue:1

    Topics: Adult; Anesthetics, Local; Bupivacaine; Female; Glucocorticoids; Humans; Injections; Male; Middle Ag

2015
Cortisone injection with anesthetic additives for radial epicondylalgia (tennis elbow).
    Clinical orthopaedics and related research, 1995, Issue:316

    Topics: Adolescent; Adult; Aged; Bupivacaine; Double-Blind Method; Drug Combinations; Female; Humans; Lidoca

1995
Cortisone injection with anesthetic additives for radial epicondylalgia (tennis elbow).
    Clinical orthopaedics and related research, 1995, Issue:316

    Topics: Adolescent; Adult; Aged; Bupivacaine; Double-Blind Method; Drug Combinations; Female; Humans; Lidoca

1995
Cortisone injection with anesthetic additives for radial epicondylalgia (tennis elbow).
    Clinical orthopaedics and related research, 1995, Issue:316

    Topics: Adolescent; Adult; Aged; Bupivacaine; Double-Blind Method; Drug Combinations; Female; Humans; Lidoca

1995
Cortisone injection with anesthetic additives for radial epicondylalgia (tennis elbow).
    Clinical orthopaedics and related research, 1995, Issue:316

    Topics: Adolescent; Adult; Aged; Bupivacaine; Double-Blind Method; Drug Combinations; Female; Humans; Lidoca

1995
Cortisone injection with anesthetic additives for radial epicondylalgia (tennis elbow).
    Clinical orthopaedics and related research, 1995, Issue:316

    Topics: Adolescent; Adult; Aged; Bupivacaine; Double-Blind Method; Drug Combinations; Female; Humans; Lidoca

1995
Cortisone injection with anesthetic additives for radial epicondylalgia (tennis elbow).
    Clinical orthopaedics and related research, 1995, Issue:316

    Topics: Adolescent; Adult; Aged; Bupivacaine; Double-Blind Method; Drug Combinations; Female; Humans; Lidoca

1995
Cortisone injection with anesthetic additives for radial epicondylalgia (tennis elbow).
    Clinical orthopaedics and related research, 1995, Issue:316

    Topics: Adolescent; Adult; Aged; Bupivacaine; Double-Blind Method; Drug Combinations; Female; Humans; Lidoca

1995
Cortisone injection with anesthetic additives for radial epicondylalgia (tennis elbow).
    Clinical orthopaedics and related research, 1995, Issue:316

    Topics: Adolescent; Adult; Aged; Bupivacaine; Double-Blind Method; Drug Combinations; Female; Humans; Lidoca

1995
Cortisone injection with anesthetic additives for radial epicondylalgia (tennis elbow).
    Clinical orthopaedics and related research, 1995, Issue:316

    Topics: Adolescent; Adult; Aged; Bupivacaine; Double-Blind Method; Drug Combinations; Female; Humans; Lidoca

1995
Corticosteroid injection in early treatment of lateral epicondylitis.
    Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine, 2001, Volume: 11, Issue:4

    Topics: Adolescent; Adult; Aged; Anesthetics, Local; Anti-Inflammatory Agents; Athletic Injuries; Betamethas

2001

Other Studies

1 other study available for bupivacaine and Epicondylitis, Lateral Humeral

ArticleYear
Lateral epicondylalgia: treatment by manipulation under anaesthetic and steroid injection and operative release.
    Acta orthopaedica Belgica, 2000, Volume: 66, Issue:5

    Topics: Adult; Anesthetics, Local; Anti-Inflammatory Agents; Bupivacaine; Combined Modality Therapy; Female;

2000