bupivacaine has been researched along with Embryopathies in 14 studies
Bupivacaine: A widely used local anesthetic agent.
1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide : A piperidinecarboxamide obtained by formal condensation of the carboxy group of N-butylpipecolic acid with the amino group of 2,6-dimethylaniline.
bupivacaine : A racemate composed of equimolar amounts of dextrobupivacaine and levobupivacaine. Used (in the form of its hydrochloride hydrate) as a local anaesthetic.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Therefore, tissue acidosis may result in ionization and "trapping" of the basic local anaesthetics The following study was done in the pregnant ewe to determine if the highly protein-bound local anaesthetic bupivacaine demonstrates ion-trapping in the acidotic foetus." | 7.66 | The effect of foetal acidosis on bupivacaine levels in utero. ( Biehl, D; Meatherall, R; Pickering, B, 1981) |
| "To report the use of regional anesthesia and iv nitroglycerin to provide anesthesia and uterine relaxation for three Cesarean deliveries (CD) involving ex utero intrapartum treatment (EXIT) of potentially life-threatening airway obstruction in the newborn." | 3.74 | Case series: Combined spinal epidural anesthesia for Cesarean delivery and ex utero intrapartum treatment procedure. ( George, RB; Habib, AS; Melnick, AH; Rose, EC, 2007) |
| " Therefore, tissue acidosis may result in ionization and "trapping" of the basic local anaesthetics The following study was done in the pregnant ewe to determine if the highly protein-bound local anaesthetic bupivacaine demonstrates ion-trapping in the acidotic foetus." | 3.66 | The effect of foetal acidosis on bupivacaine levels in utero. ( Biehl, D; Meatherall, R; Pickering, B, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (57.14) | 18.7374 |
| 1990's | 3 (21.43) | 18.2507 |
| 2000's | 2 (14.29) | 29.6817 |
| 2010's | 1 (7.14) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Clivatti, J | 1 |
| Siddiqui, N | 1 |
| Goel, A | 1 |
| Shaw, M | 1 |
| Crisan, I | 1 |
| Carvalho, JC | 1 |
| Kuczkowski, KM | 1 |
| George, RB | 1 |
| Melnick, AH | 1 |
| Rose, EC | 1 |
| Habib, AS | 1 |
| Pickering, B | 1 |
| Biehl, D | 1 |
| Meatherall, R | 1 |
| Vincenti, E | 1 |
| Tambuscio, B | 1 |
| Mega, M | 1 |
| Fais, GF | 1 |
| Polato, D | 1 |
| Pitton, MA | 1 |
| Di Lenardo, L | 1 |
| Ambrosini, A | 1 |
| Räsänen, J | 1 |
| Jouppila, P | 1 |
| Nielsen, PE | 1 |
| Erickson, JR | 1 |
| Abouleish, EI | 1 |
| Perriatt, S | 1 |
| Sheppard, C | 1 |
| D'Angelo, R | 1 |
| Eisenach, JC | 1 |
| Rüther, K | 1 |
| Stockhausen, H | 1 |
| Abouleish, E | 1 |
| Diesbecq, W | 2 |
| Rolly, G | 2 |
| Thiery, M | 2 |
| De Clercq, A | 1 |
| Derom, R | 1 |
| Vroman, S | 1 |
| Moore, J | 1 |
| Murnaghan, GA | 1 |
| Lewis, MA | 1 |
| Boileau, PA | 1 |
| Turcot, MJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Pulse Pressure-guided IV Fluid Preload to Prevent Post-epidural Fetal Heart Rate (FHR) Changes: a Randomized Controlled Trial[NCT02565485] | 276 participants (Actual) | Interventional | 2015-09-01 | Completed | |||
| Plasmatic Catecholamines After Neuraxial Labor Analgesia: a Randomized Controlled Trial Comparing Epidural Versus Combined Spinal-epidural[NCT02666794] | 50 participants (Actual) | Interventional | 2017-07-12 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Pulmonary edema occurring after preload bolus through delivery was considered an adverse event. (NCT02565485)
Timeframe: Duration of intrapartum course
| Intervention | Participants (Count of Participants) |
|---|---|
| Standard IV Preload | 0 |
| Volume Replacement IV Preload | 0 |
Each fetal heart rate tracing was evaluated in 15 min increments from the completion of epidural placement and initial dose administration. ACOG Category I, II, and III was assigned to each 15 min increment. (NCT02565485)
Timeframe: First 60 minutes following epidural placement
| Intervention | Participants (Count of Participants) |
|---|---|
| Standard IV Preload | 72 |
| Volume Replacement IV Preload | 52 |
(NCT02565485)
Timeframe: First 60 minutes following epidural placement
| Intervention | Participants (Count of Participants) |
|---|---|
| Standard IV Preload | 61 |
| Volume Replacement IV Preload | 25 |
(NCT02565485)
Timeframe: First 60 minutes following epidural placement
| Intervention | Participants (Count of Participants) |
|---|---|
| Standard IV Preload | 48 |
| Volume Replacement IV Preload | 14 |
1 trial available for bupivacaine and Embryopathies
| Article | Year |
|---|---|
Fetal heart rate changes after intrathecal sufentanil or epidural bupivacaine for labor analgesia: incidence and clinical significance.
Topics: Adult; Analgesia, Epidural; Analgesia, Obstetrical; Analgesics, Opioid; Anesthetics, Local; Bradycar | 1996 |
Fetal heart rate changes after intrathecal sufentanil or epidural bupivacaine for labor analgesia: incidence and clinical significance.
Topics: Adult; Analgesia, Epidural; Analgesia, Obstetrical; Analgesics, Opioid; Anesthetics, Local; Bradycar | 1996 |
Fetal heart rate changes after intrathecal sufentanil or epidural bupivacaine for labor analgesia: incidence and clinical significance.
Topics: Adult; Analgesia, Epidural; Analgesia, Obstetrical; Analgesics, Opioid; Anesthetics, Local; Bradycar | 1996 |
Fetal heart rate changes after intrathecal sufentanil or epidural bupivacaine for labor analgesia: incidence and clinical significance.
Topics: Adult; Analgesia, Epidural; Analgesia, Obstetrical; Analgesics, Opioid; Anesthetics, Local; Bradycar | 1996 |
13 other studies available for bupivacaine and Embryopathies
| Article | Year |
|---|---|
Quality of labour neuraxial analgesia and maternal satisfaction at a tertiary care teaching hospital: a prospective observational study.
Topics: Adjuvants, Anesthesia; Adult; Analgesia, Epidural; Analgesia, Obstetrical; Analgesia, Patient-Contro | 2013 |
Severe persistent fetal bradycardia following subarachnoid administration of fentanyl and bupivacaine for induction of a combined spinal-epidural analgesia for labor pain.
Topics: Adult; Analgesia, Epidural; Analgesia, Obstetrical; Analgesics, Opioid; Anesthesia, Spinal; Anesthet | 2004 |
Case series: Combined spinal epidural anesthesia for Cesarean delivery and ex utero intrapartum treatment procedure.
Topics: Adult; Airway Obstruction; Anesthesia, Epidural; Anesthesia, Obstetrical; Anesthesia, Spinal; Bupiva | 2007 |
The effect of foetal acidosis on bupivacaine levels in utero.
Topics: Acidosis; Animals; Bupivacaine; Female; Fetal Diseases; Hemodynamics; Humans; Hydrogen-Ion Concentra | 1981 |
Cardiotocographic modifications during continuous epidural anaesthesia in labour.
Topics: Adult; Anesthesia, Epidural; Anesthesia, Obstetrical; Bradycardia; Bupivacaine; Female; Fetal Diseas | 1981 |
Does a paracervical block with bupivacaine change vascular resistance in uterine and umbilical arteries?
Topics: Analgesia, Obstetrical; Blood Flow Velocity; Bradycardia; Bupivacaine; Cervix Uteri; Evaluation Stud | 1994 |
Severe maternal hypotension and fetal bradycardia after a combined spinal epidural anesthetic.
Topics: Adult; Anesthesia, Epidural; Anesthesia, Obstetrical; Anesthetics, Combined; Bradycardia; Bupivacain | 1997 |
[Critical evaluation of paracervical anaesthesia in obstetrics (personal observations in 8038 cases) (author's transl)].
Topics: Anesthesia, Obstetrical; Anesthesia, Spinal; Bradycardia; Bupivacaine; Cervix Uteri; Cesarean Sectio | 1975 |
Foetal bradycardia during caudal analgesia: A discussion of possible causative factors.
Topics: Adult; Anesthesia, Caudal; Anesthesia, Epidural; Bradycardia; Bupivacaine; Female; Fetal Diseases; F | 1976 |
Continuous lumbar epidural analgesia during labor and delivery.
Topics: Adult; Anesthesia, Epidural; Anesthesia, Obstetrical; Back Pain; Bradycardia; Bupivacaine; Female; F | 1974 |
The fetal influence of continuous lumbar epidural analgesia in labor.
Topics: Adolescent; Adult; Anesthesia, Epidural; Anesthesia, Obstetrical; Bupivacaine; Female; Fetal Disease | 1974 |
A clinical evaluation of the maternal effects of lumbar extradural analgesia for labour.
Topics: Anesthesia, Epidural; Anesthesia, Obstetrical; Bupivacaine; Cesarean Section; Epinephrine; Extractio | 1974 |
[Para-cervical block in obstetrics. Preliminary studies on bupivacaine and the use of magnesium sulfate in the control of fetal bradycardia].
Topics: Adolescent; Adult; Anesthesia, Conduction; Anesthesia, Obstetrical; Blood Pressure; Bradycardia; Bup | 1972 |