bupivacaine has been researched along with Drug Overdose in 23 studies
Bupivacaine: A widely used local anesthetic agent.
1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide : A piperidinecarboxamide obtained by formal condensation of the carboxy group of N-butylpipecolic acid with the amino group of 2,6-dimethylaniline.
bupivacaine : A racemate composed of equimolar amounts of dextrobupivacaine and levobupivacaine. Used (in the form of its hydrochloride hydrate) as a local anaesthetic.
Drug Overdose: Accidental or deliberate use of a medication or street drug in excess of normal dosage.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Thirty-two rats were subjected to bupivacaine to induce asystole." | 3.78 | Association of sustained cardiovascular recovery with epinephrine in the delayed lipid-based resuscitation from cardiac arrest induced by bupivacaine overdose in rats. ( Hu, Z; Li, B; Ma, Z; Shen, Y; Yan, J, 2012) |
| " Fifteen minutes later, each group was randomly subdivided into two equal groups and an infusion of bupivacaine or ropivacaine, 3 mg kg(-1) min(-1), was given until cardiac arrest (asystole) occurred." | 3.72 | Effects of clonidine pre-treatment on bupivacaine and ropivacaine cardiotoxicity in rats. ( Aydin, Y; Gulec, S; Senturk, Y; Uzuner, K; Yelken, B, 2004) |
| "The development of safe and effective local anesthetic agents has possibly been the most important advancement in dental science to occur in the last century." | 2.46 | Local anesthetics: pharmacology and toxicity. ( Hersh, EV; Moore, PA, 2010) |
| " IFE therapy is being recommended by US PCCs; protocols and dosing regimens are nearly uniform." | 1.39 | Lipid rescue 911: Are poison centers recommending intravenous fat emulsion therapy for severe poisoning? ( Christian, MR; Mycyk, MB; Pallasch, EM; Wahl, M, 2013) |
| "Physiologically based pharmacokinetic (PBPK) models were developed for design and optimization of liposome therapy for treatment of overdoses of tricyclic antidepressants and local anesthetics." | 1.36 | A physiologically based pharmacokinetic (PBPK) model for predicting the efficacy of drug overdose treatment with liposomes in man. ( Chauhan, A; Howell, BA, 2010) |
| "Bupivacaine, 20 mg/kg, was infused in rats anesthetized with isoflurane, producing asystole in all subjects." | 1.35 | Resuscitation with lipid versus epinephrine in a rat model of bupivacaine overdose. ( Di Gregorio, G; Edelman, L; Feinstein, DL; Kelly, K; Massad, M; Ripper, R; Schwartz, D; Shah, N; Weinberg, GL; Zheng, S, 2008) |
| "Pregnancy in a patient in a persistent vegetative state presents challenging therapeutic questions about the level of supportive management required, the assessment of fetal well-being, the timing and mode of delivery and the anaesthetic management of labour and delivery." | 1.31 | Anaesthetic management of a pregnant patient in a persistent vegetative state. ( Ayorinde, BT; Buggy, DJ; Scudamore, I, 2000) |
| "Bupivacaine (3." | 1.30 | Blood pressure is maintained despite profound myocardial depression during acute bupivacaine overdose in pigs. ( Buffington, CW; Heavner, JE; Nyström, EU, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (17.39) | 18.2507 |
| 2000's | 13 (56.52) | 29.6817 |
| 2010's | 6 (26.09) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Christian, MR | 1 |
| Pallasch, EM | 1 |
| Wahl, M | 1 |
| Mycyk, MB | 1 |
| Whiteman, DM | 1 |
| Kushins, SI | 1 |
| Buck, D | 1 |
| Kreeger, R | 1 |
| Spaeth, J | 1 |
| Hiller, DB | 1 |
| Gregorio, GD | 1 |
| Ripper, R | 2 |
| Kelly, K | 2 |
| Massad, M | 2 |
| Edelman, L | 2 |
| Edelman, G | 1 |
| Feinstein, DL | 2 |
| Weinberg, GL | 2 |
| Howell, BA | 1 |
| Chauhan, A | 1 |
| Moore, PA | 1 |
| Hersh, EV | 1 |
| Li, B | 2 |
| Yan, J | 1 |
| Shen, Y | 1 |
| Hu, Z | 1 |
| Ma, Z | 1 |
| Wildsmith, JA | 2 |
| Gulec, S | 1 |
| Aydin, Y | 1 |
| Uzuner, K | 1 |
| Yelken, B | 1 |
| Senturk, Y | 1 |
| Mayr, VD | 1 |
| Raedler, C | 1 |
| Wenzel, V | 1 |
| Lindner, KH | 1 |
| Strohmenger, HU | 1 |
| Picard, J | 1 |
| Meek, T | 1 |
| Weaver, JM | 1 |
| Jung, CW | 1 |
| Kim, JT | 1 |
| Lee, KH | 1 |
| Powell, E | 1 |
| Lee, YH | 1 |
| Partch, R | 1 |
| Dennis, D | 1 |
| Morey, T | 1 |
| Varshney, M | 1 |
| Di Gregorio, G | 1 |
| Schwartz, D | 1 |
| Shah, N | 1 |
| Zheng, S | 1 |
| Kemble, J | 1 |
| Holz, P | 1 |
| Russell, AW | 1 |
| Butterworth, J | 2 |
| James, RL | 2 |
| Grimes, J | 1 |
| Nyström, EU | 1 |
| Heavner, JE | 1 |
| Buffington, CW | 1 |
| Nitecki, SS | 1 |
| Kleiser, A | 1 |
| Ofer, A | 1 |
| Karram, T | 1 |
| Engel, A | 1 |
| Eisenberg, E | 1 |
| Hoffman, A | 1 |
| Groban, L | 1 |
| Deal, DD | 1 |
| Vernon, JC | 1 |
| Ayorinde, BT | 1 |
| Scudamore, I | 1 |
| Buggy, DJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Intravenous Lidocaine for Postoperative Recovery in Liver Surgery, a Randomized Double Blinded Placebo-controlled Study[NCT05153785] | Phase 2/Phase 3 | 80 participants (Anticipated) | Interventional | 2021-11-15 | Recruiting | ||
| Methemoglobin Levels in Generally Anesthetized Pediatric Dental Patients Receiving Prilocaine Versus Lidocaine[NCT01402869] | 91 participants (Actual) | Interventional | 2011-08-31 | Completed | |||
| An Investigation Into the Effects of Intravenous Lipid Emulsion (ILE) on the Pharmacokinetic and Pharmacodynamic Properties of Metoprolol.[NCT02924454] | Phase 4 | 10 participants (Actual) | Interventional | 2016-09-30 | Completed | ||
| Safety of Local Dental Anesthesia in Patients With Cardiac Channelopathies[NCT03182777] | 31 participants (Actual) | Interventional | 2015-05-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Change in percentage of methemoglobin in blood from baseline level to peak level (NCT01402869)
Timeframe: From administration of local anesthetic or start of restorative procedures to time at which maximum methemoglobin blood level was documented during dental treatment for an average of 2 hours
| Intervention | percentage of methemoglobin in blood (Mean) |
|---|---|
| Prilocaine | 2.73 |
| Lidocaine | 0.78 |
| No Local Anesthetic | 0.76 |
The maximum percentage of methemoglobin in blood (NCT01402869)
Timeframe: Measured at 10 second intervals during dental treatment for an average of 2 hours
| Intervention | percentage of methemoglobin in blood (Mean) |
|---|---|
| Prilocaine | 3.55 |
| Lidocaine | 1.63 |
| No Local Anesthetic | 1.60 |
The length of time between the administration of local anesthetic (Prilocaine and Lidocaine Groups) or start of restorative dental procedures (No local anesthetic Group) and the time at which the maximum methemoglobin blood level is observed. (NCT01402869)
Timeframe: Measured at 10 second intervals during dental treatment for an average of 2 hours
| Intervention | minutes (Mean) |
|---|---|
| Prilocaine | 62.73 |
| Lidocaine | 57.50 |
| No Local Anesthetic | 29.50 |
1 review available for bupivacaine and Drug Overdose
| Article | Year |
|---|---|
Local anesthetics: pharmacology and toxicity.
Topics: Anesthesia, Dental; Anesthetics, Local; Bupivacaine; Carticaine; Drug Overdose; Humans; Hydrogen-Ion | 2010 |
Local anesthetics: pharmacology and toxicity.
Topics: Anesthesia, Dental; Anesthetics, Local; Bupivacaine; Carticaine; Drug Overdose; Humans; Hydrogen-Ion | 2010 |
Local anesthetics: pharmacology and toxicity.
Topics: Anesthesia, Dental; Anesthetics, Local; Bupivacaine; Carticaine; Drug Overdose; Humans; Hydrogen-Ion | 2010 |
Local anesthetics: pharmacology and toxicity.
Topics: Anesthesia, Dental; Anesthetics, Local; Bupivacaine; Carticaine; Drug Overdose; Humans; Hydrogen-Ion | 2010 |
22 other studies available for bupivacaine and Drug Overdose
| Article | Year |
|---|---|
Lipid rescue 911: Are poison centers recommending intravenous fat emulsion therapy for severe poisoning?
Topics: Acute Disease; Adult; Amitriptyline; Bupivacaine; Drug Overdose; Fat Emulsions, Intravenous; Guideli | 2013 |
Successful Resuscitation With Intralipid After Marcaine Overdose.
Topics: Adult; Anesthetics, Local; Bupivacaine; Drug Overdose; Emulsions; Female; Heart Arrest; Humans; Infu | 2014 |
Case discussion and root cause analysis: bupivacaine overdose in an infant leading to ventricular tachycardia.
Topics: Anesthetics, Local; Bupivacaine; Drug Overdose; Humans; Infant; Male; Root Cause Analysis; Tachycard | 2014 |
Epinephrine impairs lipid resuscitation from bupivacaine overdose: a threshold effect.
Topics: Anesthetics, Local; Animals; Blood Gas Analysis; Blood Pressure; Bupivacaine; Drug Overdose; Electro | 2009 |
A physiologically based pharmacokinetic (PBPK) model for predicting the efficacy of drug overdose treatment with liposomes in man.
Topics: Algorithms; Amitriptyline; Anesthetics, Local; Antidepressive Agents, Tricyclic; Area Under Curve; B | 2010 |
Association of sustained cardiovascular recovery with epinephrine in the delayed lipid-based resuscitation from cardiac arrest induced by bupivacaine overdose in rats.
Topics: Anesthetics, Local; Animals; Bupivacaine; Combined Modality Therapy; Disease Models, Animal; Drug Ad | 2012 |
Confidential enquiries into maternal deaths, 1997-1999.
Topics: Anesthesia, Obstetrical; Anesthetics, Local; Bupivacaine; Cause of Death; Drug Overdose; Female; Hum | 2003 |
Effects of clonidine pre-treatment on bupivacaine and ropivacaine cardiotoxicity in rats.
Topics: Adrenergic alpha-Agonists; Amides; Anesthetics, Local; Animals; Arrhythmias, Cardiac; Blood Pressure | 2004 |
Lipid, not propofol, treats bupivacaine overdose.
Topics: Anesthetics, Intravenous; Anesthetics, Local; Animals; Bupivacaine; Dogs; Drug Overdose; Fat Emulsio | 2004 |
A response to 'lipid emulsion to treat bupivacaine toxicity'.
Topics: Anesthetics, Local; Animals; Bupivacaine; Dogs; Drug Overdose; Fat Emulsions, Intravenous | 2005 |
Local anaesthetic toxicity: prevention or cure?
Topics: Anesthetics, Local; Bupivacaine; Drug Overdose; Fat Emulsions, Intravenous; Humans | 2006 |
Calculating the maximum recommended dose of local anesthetic.
Topics: Adult; Anesthesia, Dental; Anesthetics, Local; Body Weight; Bupivacaine; Child; Drug Interactions; D | 2007 |
The hemodynamic effects of insulin following overdosage with levobupivacaine or racemic bupivacaine in dogs.
Topics: Anesthetics, Local; Animals; Blood Flow Velocity; Blood Pressure; Bupivacaine; Cardiac Output; Cardi | 2007 |
Pi-Pi complexation of bupivacaine and analogues with aromatic receptors: implications for overdose remediation.
Topics: Animals; Bupivacaine; Chelating Agents; Chemistry, Pharmaceutical; Cocaine; Drug Carriers; Drug Over | 2007 |
Resuscitation with lipid versus epinephrine in a rat model of bupivacaine overdose.
Topics: Anesthetics, Local; Animals; Bupivacaine; Disease Models, Animal; Drug Overdose; Epinephrine; Heart; | 2008 |
Preventing epidural overdose.
Topics: Analgesia, Epidural; Bupivacaine; Drug Overdose; Equipment Design; Fentanyl; Humans; Infusion Pumps | 1995 |
Inadvertent epidural overdose.
Topics: Aged; Analgesia, Epidural; Bupivacaine; Drug Overdose; Equipment Design; Equipment Failure; Female; | 1994 |
Structure-affinity relationships and stereospecificity of several homologous series of local anesthetics for the beta2-adrenergic receptor.
Topics: Adrenergic beta-2 Receptor Antagonists; Adrenergic beta-Antagonists; Adult; Alkanes; Amides; Anesthe | 1997 |
Blood pressure is maintained despite profound myocardial depression during acute bupivacaine overdose in pigs.
Topics: Anesthetics, Local; Animals; Blood Pressure; Bupivacaine; Depression, Chemical; Drug Overdose; Elect | 1999 |
Severe ergot-induced lower limb ischaemia treated by epidural local anaesthetic.
Topics: Analgesia, Epidural; Anesthetics, Local; Bupivacaine; Drug Overdose; Ergotamine; Female; Humans; Isc | 2000 |
Ventricular arrhythmias with or without programmed electrical stimulation after incremental overdosage with lidocaine, bupivacaine, levobupivacaine, and ropivacaine.
Topics: Amides; Anesthetics, Local; Animals; Bupivacaine; Cardiac Pacing, Artificial; Dogs; Drug Overdose; L | 2000 |
Anaesthetic management of a pregnant patient in a persistent vegetative state.
Topics: Adult; Amnion; Anesthesia, Epidural; Anesthesia, Obstetrical; Anesthetics, Local; Bupivacaine; Decis | 2000 |