Page last updated: 2024-10-24

bupivacaine and Colonic Diseases

bupivacaine has been researched along with Colonic Diseases in 6 studies

Bupivacaine: A widely used local anesthetic agent.
1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide : A piperidinecarboxamide obtained by formal condensation of the carboxy group of N-butylpipecolic acid with the amino group of 2,6-dimethylaniline.
bupivacaine : A racemate composed of equimolar amounts of dextrobupivacaine and levobupivacaine. Used (in the form of its hydrochloride hydrate) as a local anaesthetic.

Colonic Diseases: Pathological processes in the COLON region of the large intestine (INTESTINE, LARGE).

Research Excerpts

ExcerptRelevanceReference
"The study measured postoperative pain scores and opioid requirements."1.46Liposomal Bupivacaine Use in Transversus Abdominis Plane Blocks Reduces Pain and Postoperative Intravenous Opioid Requirement After Colorectal Surgery. ( Adhikary, SD; Choi, CS; Hollenbeak, CS; Messaris, E; Puleo, FJ; Quintili, A; Stokes, AL, 2017)

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (16.67)18.2507
2000's1 (16.67)29.6817
2010's4 (66.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Keller, DS2
Stulberg, JJ1
Lawrence, JK1
Delaney, CP2
Tahilramani, RN1
Flores-Gonzalez, JR1
Ibarra, S1
Haas, EM1
Stokes, AL1
Adhikary, SD1
Quintili, A1
Puleo, FJ1
Choi, CS1
Hollenbeak, CS1
Messaris, E1
Stuhldreher, JM1
Adamina, M1
Konopacka, A1
Brady, K1
Errando, CL1
Peiró, C1
Schulze, S1
Sommer, P1
Bigler, D1
Honnens, M1
Shenkin, A1
Cruickshank, AM1
Bukhave, K1
Kehlet, H1

Clinical Trials (4)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Bilateral Mid-Abdominal Transverse Abdominis Plane and Rectus Sheath Blocks Comparing The Use of Liposomal Bupivacaine/Bupivacaine vs. Regular Bupivacaine in Laparoscopic Colectomy Procedures.[NCT05224089]Phase 4114 participants (Anticipated)Interventional2022-04-27Recruiting
TAP Blocks Performed With Bupivacaine Versus Liposomal Bupivacaine in Colorectal Surgery Patients: A Prospective, Cluster Randomized Trial[NCT03638635]Phase 463 participants (Actual)Interventional2018-05-14Terminated (stopped due to Lack of personnel available to complete study.)
"Analgesic Efficacy of Combined Transversus Abdominis Plane Block and Posterior Rectus Sheath Block in Patients Undergoing Laparoscopic Appendectomy"[NCT06088082]Phase 3100 participants (Anticipated)Interventional2023-10-01Active, not recruiting
Increased Postoperative Opioid Use is a Risk Factor for an Ileus After Laparoscopic Colorectal Surgery---A Case Control Study[NCT05262569]596 participants (Actual)Observational2022-04-01Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

In-hospital Antiemetic Use

Amount of ondansetron patient required postoperatively during hospital stay, in milligrams (NCT03638635)
Timeframe: Time of transfer to post operative suite to time of discharge (usually up to 4 days after surgery).

Interventionmg (Mean)
Standard Bupivacaine2.9
Bupivacaine Liposome5.6

Length of Stay

Total postoperative hospital stay in days (NCT03638635)
Timeframe: Date of surgery to date of discharge (usually up to 4 days after surgery).

Interventiondays (Median)
Standard Bupivacaine3
Bupivacaine Liposome3.5

Pain Score

Recorded on a scale of 0 (No pain) to 10 (Worst possible pain) (NCT03638635)
Timeframe: Approximately every 6 hours through postoperative day 3 by 1 pm

Interventionunits on a scale (Median)
Standard Bupivacaine3
Bupivacaine Liposome3

Time to Clear Liquid Diet

Number of days from time of surgery until patient tolerates clear liquid diet (NCT03638635)
Timeframe: From time of surgery until first time patient tolerates clear liquids without nausea or vomiting. Assessed until date of discharge (usually up to 4 days after surgery).

Interventiondays (Median)
Standard Bupivacaine0
Bupivacaine Liposome0

Time to Low Fiber Diet

Number of days from day of surgery until patient tolerates low fiber diet (NCT03638635)
Timeframe: From time of surgery until first time patient tolerates a low fiber diet without nausea or vomiting. Assessed until date of discharge (usually up to 4 days after surgery).

Interventiondays (Median)
Standard Bupivacaine1.5
Bupivacaine Liposome1

Time to Patient Mobilization

Number of days from day of surgery until patient mobilization (NCT03638635)
Timeframe: From time of surgery until time of first patient ambulation post op. Assessed until date of discharge (usually up to 4 days after surgery).

Interventiondays (Median)
Standard Bupivacaine1
Bupivacaine Liposome0.5

Time to Return of Bowel Function

Number of days from time of surgery until return of bowel function (NCT03638635)
Timeframe: From time of surgery until first time patient passes gas or stool per rectum or into ostomy bag. Assessed until date of discharge (usually up to 4 days after surgery).

Interventiondays (Median)
Standard Bupivacaine2
Bupivacaine Liposome2

Trials

2 trials available for bupivacaine and Colonic Diseases

ArticleYear
Pilot study of a novel pain management strategy: evaluating the impact on patient outcomes.
    Surgical endoscopy, 2016, Volume: 30, Issue:6

    Topics: Analgesics, Opioid; Bupivacaine; Colonic Diseases; Colorectal Surgery; Elective Surgical Procedures;

2016
Effect of combined prednisolone, epidural analgesia, and indomethacin on the systemic response after colonic surgery.
    Archives of surgery (Chicago, Ill. : 1960), 1992, Volume: 127, Issue:3

    Topics: Acetaminophen; Activities of Daily Living; Aged; Analgesia, Epidural; Body Temperature; Bupivacaine;

1992

Other Studies

4 other studies available for bupivacaine and Colonic Diseases

ArticleYear
Process control to measure process improvement in colorectal surgery: modifications to an established enhanced recovery pathway.
    Diseases of the colon and rectum, 2014, Volume: 57, Issue:2

    Topics: Abdominal Muscles; Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Anesthetics, Local; Bupivac

2014
Liposomal Bupivacaine Use in Transversus Abdominis Plane Blocks Reduces Pain and Postoperative Intravenous Opioid Requirement After Colorectal Surgery.
    Diseases of the colon and rectum, 2017, Volume: 60, Issue:2

    Topics: Abdominal Muscles; Administration, Intravenous; Analgesics, Opioid; Anesthetics, Local; Bupivacaine;

2017
Liposomal Bupivacaine Use in Transversus Abdominis Plane Blocks Reduces Pain and Postoperative Intravenous Opioid Requirement After Colorectal Surgery.
    Diseases of the colon and rectum, 2017, Volume: 60, Issue:2

    Topics: Abdominal Muscles; Administration, Intravenous; Analgesics, Opioid; Anesthetics, Local; Bupivacaine;

2017
Liposomal Bupivacaine Use in Transversus Abdominis Plane Blocks Reduces Pain and Postoperative Intravenous Opioid Requirement After Colorectal Surgery.
    Diseases of the colon and rectum, 2017, Volume: 60, Issue:2

    Topics: Abdominal Muscles; Administration, Intravenous; Analgesics, Opioid; Anesthetics, Local; Bupivacaine;

2017
Liposomal Bupivacaine Use in Transversus Abdominis Plane Blocks Reduces Pain and Postoperative Intravenous Opioid Requirement After Colorectal Surgery.
    Diseases of the colon and rectum, 2017, Volume: 60, Issue:2

    Topics: Abdominal Muscles; Administration, Intravenous; Analgesics, Opioid; Anesthetics, Local; Bupivacaine;

2017
Liposomal Bupivacaine Use in Transversus Abdominis Plane Blocks Reduces Pain and Postoperative Intravenous Opioid Requirement After Colorectal Surgery.
    Diseases of the colon and rectum, 2017, Volume: 60, Issue:2

    Topics: Abdominal Muscles; Administration, Intravenous; Analgesics, Opioid; Anesthetics, Local; Bupivacaine;

2017
Liposomal Bupivacaine Use in Transversus Abdominis Plane Blocks Reduces Pain and Postoperative Intravenous Opioid Requirement After Colorectal Surgery.
    Diseases of the colon and rectum, 2017, Volume: 60, Issue:2

    Topics: Abdominal Muscles; Administration, Intravenous; Analgesics, Opioid; Anesthetics, Local; Bupivacaine;

2017
Liposomal Bupivacaine Use in Transversus Abdominis Plane Blocks Reduces Pain and Postoperative Intravenous Opioid Requirement After Colorectal Surgery.
    Diseases of the colon and rectum, 2017, Volume: 60, Issue:2

    Topics: Abdominal Muscles; Administration, Intravenous; Analgesics, Opioid; Anesthetics, Local; Bupivacaine;

2017
Liposomal Bupivacaine Use in Transversus Abdominis Plane Blocks Reduces Pain and Postoperative Intravenous Opioid Requirement After Colorectal Surgery.
    Diseases of the colon and rectum, 2017, Volume: 60, Issue:2

    Topics: Abdominal Muscles; Administration, Intravenous; Analgesics, Opioid; Anesthetics, Local; Bupivacaine;

2017
Liposomal Bupivacaine Use in Transversus Abdominis Plane Blocks Reduces Pain and Postoperative Intravenous Opioid Requirement After Colorectal Surgery.
    Diseases of the colon and rectum, 2017, Volume: 60, Issue:2

    Topics: Abdominal Muscles; Administration, Intravenous; Analgesics, Opioid; Anesthetics, Local; Bupivacaine;

2017
Liposomal Bupivacaine Use in Transversus Abdominis Plane Blocks Reduces Pain and Postoperative Intravenous Opioid Requirement After Colorectal Surgery.
    Diseases of the colon and rectum, 2017, Volume: 60, Issue:2

    Topics: Abdominal Muscles; Administration, Intravenous; Analgesics, Opioid; Anesthetics, Local; Bupivacaine;

2017
Liposomal Bupivacaine Use in Transversus Abdominis Plane Blocks Reduces Pain and Postoperative Intravenous Opioid Requirement After Colorectal Surgery.
    Diseases of the colon and rectum, 2017, Volume: 60, Issue:2

    Topics: Abdominal Muscles; Administration, Intravenous; Analgesics, Opioid; Anesthetics, Local; Bupivacaine;

2017
Liposomal Bupivacaine Use in Transversus Abdominis Plane Blocks Reduces Pain and Postoperative Intravenous Opioid Requirement After Colorectal Surgery.
    Diseases of the colon and rectum, 2017, Volume: 60, Issue:2

    Topics: Abdominal Muscles; Administration, Intravenous; Analgesics, Opioid; Anesthetics, Local; Bupivacaine;

2017
Liposomal Bupivacaine Use in Transversus Abdominis Plane Blocks Reduces Pain and Postoperative Intravenous Opioid Requirement After Colorectal Surgery.
    Diseases of the colon and rectum, 2017, Volume: 60, Issue:2

    Topics: Abdominal Muscles; Administration, Intravenous; Analgesics, Opioid; Anesthetics, Local; Bupivacaine;

2017
Liposomal Bupivacaine Use in Transversus Abdominis Plane Blocks Reduces Pain and Postoperative Intravenous Opioid Requirement After Colorectal Surgery.
    Diseases of the colon and rectum, 2017, Volume: 60, Issue:2

    Topics: Abdominal Muscles; Administration, Intravenous; Analgesics, Opioid; Anesthetics, Local; Bupivacaine;

2017
Liposomal Bupivacaine Use in Transversus Abdominis Plane Blocks Reduces Pain and Postoperative Intravenous Opioid Requirement After Colorectal Surgery.
    Diseases of the colon and rectum, 2017, Volume: 60, Issue:2

    Topics: Abdominal Muscles; Administration, Intravenous; Analgesics, Opioid; Anesthetics, Local; Bupivacaine;

2017
Liposomal Bupivacaine Use in Transversus Abdominis Plane Blocks Reduces Pain and Postoperative Intravenous Opioid Requirement After Colorectal Surgery.
    Diseases of the colon and rectum, 2017, Volume: 60, Issue:2

    Topics: Abdominal Muscles; Administration, Intravenous; Analgesics, Opioid; Anesthetics, Local; Bupivacaine;

2017
Effect of local anesthetics on postoperative pain and opioid consumption in laparoscopic colorectal surgery.
    Surgical endoscopy, 2012, Volume: 26, Issue:6

    Topics: Administration, Cutaneous; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Analysis of Variance;

2012
Another explanation for bowel and bladder dysfunction after spinal bupivacaine.
    Anesthesiology, 2002, Volume: 97, Issue:2

    Topics: Anesthesia, Spinal; Bupivacaine; Colonic Diseases; Humans; Supine Position; Urinary Bladder Diseases

2002