Page last updated: 2024-10-24

bupivacaine and Circulatory Collapse

bupivacaine has been researched along with Circulatory Collapse in 16 studies

Bupivacaine: A widely used local anesthetic agent.
1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide : A piperidinecarboxamide obtained by formal condensation of the carboxy group of N-butylpipecolic acid with the amino group of 2,6-dimethylaniline.
bupivacaine : A racemate composed of equimolar amounts of dextrobupivacaine and levobupivacaine. Used (in the form of its hydrochloride hydrate) as a local anaesthetic.

Research Excerpts

ExcerptRelevanceReference
"Insulin effectively reversed the sudden-onset circulatory collapse in dogs caused by an intravenous bolus injection of bupivacaine."7.79Insulin/glucose infusion successfully resuscitates bupivacaine-induced sudden-onset circulatory collapse in dogs. ( Kang, BC; Kim, CM; Kim, CS; Kim, MH; Lee, KH; Uugangerel, T; Yang, S, 2013)
"This study examined whether combining lipid emulsion and advanced cardiac life support (ACLS) improves survival in an unanesthetized swine model of bupivacaine- and hypoxia-induced cardiovascular collapse."7.77Combined lipid emulsion and ACLS resuscitation following bupivacaine- and hypoxia-induced cardiovascular collapse in unanesthetized swine. ( Auld, VH; Bushey, BA; Vacchiano, CA; Volk, JE, 2011)
" In contrast, ovine pregnancy does not enhance the toxicity of mepivacaine, a drug with properties similar to lidocaine."7.68Pregnancy does not alter lidocaine toxicity. ( Arthur, GR; Covino, BG; Finster, M; Morishima, HO, 1990)
"Insulin effectively reversed the sudden-onset circulatory collapse in dogs caused by an intravenous bolus injection of bupivacaine."3.79Insulin/glucose infusion successfully resuscitates bupivacaine-induced sudden-onset circulatory collapse in dogs. ( Kang, BC; Kim, CM; Kim, CS; Kim, MH; Lee, KH; Uugangerel, T; Yang, S, 2013)
"This study examined whether combining lipid emulsion and advanced cardiac life support (ACLS) improves survival in an unanesthetized swine model of bupivacaine- and hypoxia-induced cardiovascular collapse."3.77Combined lipid emulsion and ACLS resuscitation following bupivacaine- and hypoxia-induced cardiovascular collapse in unanesthetized swine. ( Auld, VH; Bushey, BA; Vacchiano, CA; Volk, JE, 2011)
" This patient developed severe perioperative hypotension after administration of 10 mg of bupivacaine through an epidural catheter, which was corrected only after potent vasopressor therapy."3.69Cardiovascular collapse during anesthesia in a patient with preoperatively discontinued chronic MAO inhibitor therapy. ( Bloomfield, EL; Distel, D; Grass, J; Lavery, IC; Sprung, J, 1996)
" In contrast, ovine pregnancy does not enhance the toxicity of mepivacaine, a drug with properties similar to lidocaine."3.68Pregnancy does not alter lidocaine toxicity. ( Arthur, GR; Covino, BG; Finster, M; Morishima, HO, 1990)
" Resuscitation was performed using open-chest heart massage, bretylium for ventricular tachycardia, and epinephrine with atropine for electromechanical dissociation and bradycardia."3.67Successful cardiovascular resuscitation after massive intravenous bupivacaine overdosage in anesthetized dogs. ( Kasten, GW; Martin, ST, 1985)
" IFE therapy is being recommended by US PCCs; protocols and dosing regimens are nearly uniform."1.39Lipid rescue 911: Are poison centers recommending intravenous fat emulsion therapy for severe poisoning? ( Christian, MR; Mycyk, MB; Pallasch, EM; Wahl, M, 2013)

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19906 (37.50)18.7374
1990's4 (25.00)18.2507
2000's1 (6.25)29.6817
2010's5 (31.25)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Kim, MH1
Lee, KH1
Kim, CS1
Yang, S1
Uugangerel, T1
Kim, CM1
Kang, BC1
Christian, MR1
Pallasch, EM1
Wahl, M1
Mycyk, MB1
Bushey, BA1
Auld, VH1
Volk, JE1
Vacchiano, CA1
Sambrook, PJ1
Smith, W1
Elijah, J1
Goss, AN1
Zider, B1
Salomäki, TE1
Laurila, PA1
Ville, J1
Marx, GF1
von Bormann, B1
Weidler, B1
Scheld, H1
Hempelmann, G1
Brown, DL1
Ransom, DM1
Hall, JA1
Leicht, CH1
Schroeder, DR1
Offord, KP1
Ngan-Kee, WD1
Lee, BB1
Sprung, J1
Distel, D1
Grass, J1
Bloomfield, EL1
Lavery, IC1
Morishima, HO2
Finster, M2
Arthur, GR2
Covino, BG2
Kasten, GW3
Martin, ST3
Pedersen, H1
Hiraoka, H1
Tsuji, A1
Feldman, HS1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
The Immune Response of Breast Cancer Patients Treated With Levobupivacaine Using Paravertebral or Superficial Chest Blocks[NCT05816538]100 participants (Anticipated)Interventional2023-04-30Not yet recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Other Studies

16 other studies available for bupivacaine and Circulatory Collapse

ArticleYear
Insulin/glucose infusion successfully resuscitates bupivacaine-induced sudden-onset circulatory collapse in dogs.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2013, Volume: 60, Issue:5

    Topics: Anesthetics, Local; Animals; Arterial Pressure; Bupivacaine; Cardiac Output; Disease Models, Animal;

2013
Lipid rescue 911: Are poison centers recommending intravenous fat emulsion therapy for severe poisoning?
    Journal of medical toxicology : official journal of the American College of Medical Toxicology, 2013, Volume: 9, Issue:3

    Topics: Acute Disease; Adult; Amitriptyline; Bupivacaine; Drug Overdose; Fat Emulsions, Intravenous; Guideli

2013
Combined lipid emulsion and ACLS resuscitation following bupivacaine- and hypoxia-induced cardiovascular collapse in unanesthetized swine.
    AANA journal, 2011, Volume: 79, Issue:2

    Topics: Advanced Cardiac Life Support; Anesthetics, Local; Animals; Bupivacaine; Combined Modality Therapy;

2011
Severe adverse reactions to dental local anaesthetics: systemic reactions.
    Australian dental journal, 2011, Volume: 56, Issue:2

    Topics: Adolescent; Adult; Adverse Drug Reaction Reporting Systems; Aged; Aged, 80 and over; Anesthesia, Den

2011
Are pigs the right model for lipid resuscitation?
    AANA journal, 2011, Volume: 79, Issue:6

    Topics: Advanced Cardiac Life Support; Animals; Bupivacaine; Fat Emulsions, Intravenous; Hypoxia; Male; Shoc

2011
Successful resuscitation after cardiovascular collapse following accidental intravenous infusion of levobupivacaine during general anesthesia.
    Anesthesiology, 2005, Volume: 103, Issue:5

    Topics: Anesthesia, General; Anesthetics, Local; Brachytherapy; Bupivacaine; Cardiopulmonary Resuscitation;

2005
Cardiotoxicity of local anesthetics--the plot thickens.
    Anesthesiology, 1984, Volume: 60, Issue:1

    Topics: Anesthesia, Obstetrical; Anesthetics, Local; Animals; Bupivacaine; Etidocaine; Female; Heart Arrest;

1984
[Antidiuretic hormone in peridural anesthesia with 0.5% bupivacaine. The effect of severe blood loss on ADH release].
    Anasthesie, Intensivtherapie, Notfallmedizin, 1982, Volume: 17, Issue:3

    Topics: Anesthesia, Epidural; Arginine Vasopressin; Blood Pressure; Bupivacaine; Carbon Dioxide; Electrolyte

1982
Regional anesthesia and local anesthetic-induced systemic toxicity: seizure frequency and accompanying cardiovascular changes.
    Anesthesia and analgesia, 1995, Volume: 81, Issue:2

    Topics: Adult; Anesthesia, Caudal; Anesthesia, Epidural; Anesthetics; Anesthetics, Local; Blood Pressure; Br

1995
Cardiovascular collapse after combined spinal anaesthesia and interscalene brachial plexus block.
    Anaesthesia and intensive care, 1995, Volume: 23, Issue:2

    Topics: Aged; Anesthesia, Spinal; Brachial Plexus; Bupivacaine; Femoral Neck Fractures; Fracture Fixation, I

1995
Cardiovascular collapse during anesthesia in a patient with preoperatively discontinued chronic MAO inhibitor therapy.
    Journal of clinical anesthesia, 1996, Volume: 8, Issue:8

    Topics: Aged; Analgesia, Epidural; Anesthesia, General; Anesthetics, Local; Bupivacaine; Colectomy; Down-Reg

1996
Pregnancy does not alter lidocaine toxicity.
    American journal of obstetrics and gynecology, 1990, Volume: 162, Issue:5

    Topics: Animals; Blood Pressure; Bupivacaine; Female; Heart Rate; Hypotension; Lidocaine; Mepivacaine; Pregn

1990
Comparison of resuscitation of sheep and dogs after bupivacaine-induced cardiovascular collapse.
    Anesthesia and analgesia, 1986, Volume: 65, Issue:10

    Topics: Animals; Bupivacaine; Cardiovascular System; Dogs; Female; Male; Resuscitation; Sheep; Shock; Specie

1986
Resuscitation from bupivacaine-induced cardiovascular toxicity during partial inferior vena cava occlusion.
    Anesthesia and analgesia, 1986, Volume: 65, Issue:4

    Topics: Animals; Bupivacaine; Constriction, Pathologic; Dogs; Female; Hemodynamics; Posture; Pregnancy; Resu

1986
Successful cardiovascular resuscitation after massive intravenous bupivacaine overdosage in anesthetized dogs.
    Anesthesia and analgesia, 1985, Volume: 64, Issue:5

    Topics: Animals; Apnea; Atropine; Bradycardia; Bupivacaine; Dogs; Electrocardiography; Epinephrine; Female;

1985
Bupivacaine toxicity in pregnant and nonpregnant ewes.
    Anesthesiology, 1985, Volume: 63, Issue:2

    Topics: Animals; Blood Pressure; Bupivacaine; Dose-Response Relationship, Drug; Etidocaine; Female; Fetus; H

1985