bupivacaine has been researched along with Central Nervous System Diseases in 14 studies
Bupivacaine: A widely used local anesthetic agent.
1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide : A piperidinecarboxamide obtained by formal condensation of the carboxy group of N-butylpipecolic acid with the amino group of 2,6-dimethylaniline.
bupivacaine : A racemate composed of equimolar amounts of dextrobupivacaine and levobupivacaine. Used (in the form of its hydrochloride hydrate) as a local anaesthetic.
Central Nervous System Diseases: Diseases of any component of the brain (including the cerebral hemispheres, diencephalon, brain stem, and cerebellum) or the spinal cord.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In various chronic painful states, the sympathetic nerve supply was blocked either by injecting the sympathetic chain and ganglia with local anaesthesia or by the injection of guanethidine during occlusion of the circulation." | 3.66 | Painful peripheral states and sympathetic blocks. ( Loh, L; Nathan, PW, 1978) |
| " Local anaesthesia is however associated with potential risks and adverse reactions including toxicity." | 2.44 | Local anaesthetic toxicity. ( Maher, AJ; Metcalfe, SA; Parr, S, 2008) |
| "Central and regional block procedures have a well-defined role as safe and effective methods in modern anesthesia and analgesia with long-acting local anesthetics." | 2.41 | The cardiotoxicity of local anesthetics: the place of ropivacaine. ( Graf, BM, 2001) |
| "Bupivacaine was the local anesthetic most commonly used in all techniques." | 1.33 | Neuraxial anesthesia and analgesia in patients with preexisting central nervous system disorders. ( Hebl, JR; Horlocker, TT; Schroeder, DR, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (28.57) | 18.7374 |
| 1990's | 1 (7.14) | 18.2507 |
| 2000's | 6 (42.86) | 29.6817 |
| 2010's | 3 (21.43) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ngeow, WC | 1 |
| Maher, AJ | 1 |
| Metcalfe, SA | 1 |
| Parr, S | 1 |
| Mather, LE | 1 |
| Sambrook, PJ | 1 |
| Smith, W | 1 |
| Elijah, J | 1 |
| Goss, AN | 1 |
| French, LK | 1 |
| Cedar, A | 1 |
| Hendrickson, RG | 1 |
| Owen, MD | 1 |
| Gautier, P | 1 |
| Hood, DD | 1 |
| Hebl, JR | 1 |
| Horlocker, TT | 1 |
| Schroeder, DR | 1 |
| Kalso, E | 1 |
| Rosenberg, PH | 1 |
| Loh, L | 2 |
| Nathan, PW | 2 |
| Schott, GD | 1 |
| Knudsen, K | 1 |
| Beckman Suurküla, M | 1 |
| Blomberg, S | 1 |
| Sjövall, J | 1 |
| Edvardsson, N | 1 |
| Ohmura, S | 1 |
| Kawada, M | 1 |
| Ohta, T | 1 |
| Yamamoto, K | 1 |
| Kobayashi, T | 1 |
| Graf, BM | 1 |
| Covino, BG | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Comparison of Plasma Concentration And Efficacy Of Liposomal Bupivacaine And Plain Bupivacaine After Intercostal Injections For Pain Management After Thoracoscopy[NCT03737292] | Phase 4 | 40 participants (Anticipated) | Interventional | 2019-04-09 | Recruiting | ||
| A Safety Study of Ropivacaine Concentrations During Continuous Erector Spinae Plane Block for Thoracic Surgery[NCT04807504] | 20 participants (Actual) | Observational | 2021-03-26 | Active, not recruiting | |||
| Ropivacaine Plasma Concentrations and Pharmacokinetics Following Erector Spinae Plane Block in the Pediatric Population[NCT04298099] | Phase 4 | 24 participants (Anticipated) | Interventional | 2020-12-17 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for bupivacaine and Central Nervous System Diseases
| Article | Year |
|---|---|
Local anaesthetic toxicity.
Topics: Amides; Anesthetics, Local; Bupivacaine; Cardiovascular Diseases; Central Nervous System Diseases; H | 2008 |
The acute toxicity of local anesthetics.
Topics: Amides; Anesthetics, Local; Animals; Bupivacaine; Cardiovascular Diseases; Central Nervous System Di | 2010 |
Bupivacaine and intravenous regional anaesthesia--a matter of controversy.
Topics: Anesthesia, Conduction; Anesthesia, Intravenous; Bupivacaine; Central Nervous System Diseases; Human | 1984 |
The cardiotoxicity of local anesthetics: the place of ropivacaine.
Topics: Action Potentials; Amides; Anesthetics, Local; Animals; Bupivacaine; Cardiovascular Diseases; Centra | 2001 |
Recent advances in local anaesthesia.
Topics: Acidosis; Anesthesia, Local; Anesthetics, Local; Animals; Arrhythmias, Cardiac; Bupivacaine; Cardiov | 1986 |
2 trials available for bupivacaine and Central Nervous System Diseases
| Article | Year |
|---|---|
Can ropivacaine and levobupivacaine be used as test doses during regional anesthesia?
Topics: Adult; Amides; Anesthesia, Conduction; Anesthetics, Local; Bupivacaine; Central Nervous System Disea | 2004 |
Central nervous and cardiovascular effects of i.v. infusions of ropivacaine, bupivacaine and placebo in volunteers.
Topics: Adult; Amides; Anesthetics, Local; Bupivacaine; Central Nervous System Diseases; Cross-Over Studies; | 1997 |
Central nervous and cardiovascular effects of i.v. infusions of ropivacaine, bupivacaine and placebo in volunteers.
Topics: Adult; Amides; Anesthetics, Local; Bupivacaine; Central Nervous System Diseases; Cross-Over Studies; | 1997 |
Central nervous and cardiovascular effects of i.v. infusions of ropivacaine, bupivacaine and placebo in volunteers.
Topics: Adult; Amides; Anesthetics, Local; Bupivacaine; Central Nervous System Diseases; Cross-Over Studies; | 1997 |
Central nervous and cardiovascular effects of i.v. infusions of ropivacaine, bupivacaine and placebo in volunteers.
Topics: Adult; Amides; Anesthetics, Local; Bupivacaine; Central Nervous System Diseases; Cross-Over Studies; | 1997 |
Central nervous and cardiovascular effects of i.v. infusions of ropivacaine, bupivacaine and placebo in volunteers.
Topics: Adult; Amides; Anesthetics, Local; Bupivacaine; Central Nervous System Diseases; Cross-Over Studies; | 1997 |
Central nervous and cardiovascular effects of i.v. infusions of ropivacaine, bupivacaine and placebo in volunteers.
Topics: Adult; Amides; Anesthetics, Local; Bupivacaine; Central Nervous System Diseases; Cross-Over Studies; | 1997 |
Central nervous and cardiovascular effects of i.v. infusions of ropivacaine, bupivacaine and placebo in volunteers.
Topics: Adult; Amides; Anesthetics, Local; Bupivacaine; Central Nervous System Diseases; Cross-Over Studies; | 1997 |
Central nervous and cardiovascular effects of i.v. infusions of ropivacaine, bupivacaine and placebo in volunteers.
Topics: Adult; Amides; Anesthetics, Local; Bupivacaine; Central Nervous System Diseases; Cross-Over Studies; | 1997 |
Central nervous and cardiovascular effects of i.v. infusions of ropivacaine, bupivacaine and placebo in volunteers.
Topics: Adult; Amides; Anesthetics, Local; Bupivacaine; Central Nervous System Diseases; Cross-Over Studies; | 1997 |
7 other studies available for bupivacaine and Central Nervous System Diseases
| Article | Year |
|---|---|
Contemporary periodontal surgery.
Topics: Anesthesia, Dental; Anesthesia, Local; Anesthetics, Local; Arrhythmias, Cardiac; Bupivacaine; Centra | 2008 |
Severe adverse reactions to dental local anaesthetics: systemic reactions.
Topics: Adolescent; Adult; Adverse Drug Reaction Reporting Systems; Aged; Aged, 80 and over; Anesthesia, Den | 2011 |
Case report: bupivacaine toxicity with dorsal penile block for circumcision.
Topics: Anesthetics, Local; Bupivacaine; Central Nervous System Diseases; Circumcision, Male; Humans; Infant | 2012 |
Neuraxial anesthesia and analgesia in patients with preexisting central nervous system disorders.
Topics: Analgesia, Epidural; Anesthesia, Epidural; Anesthesia, Spinal; Anesthetics, Local; Bupivacaine; Cent | 2006 |
Pain due to lesions of central nervous system removed by sympathetic block.
Topics: Adult; Aged; Autonomic Nerve Block; Bupivacaine; Central Nervous System Diseases; Female; Guanethidi | 1981 |
Systemic toxicity and resuscitation in bupivacaine-, levobupivacaine-, or ropivacaine-infused rats.
Topics: Adrenergic alpha-Agonists; Amides; Anesthesia; Anesthetics, Local; Animals; Arrhythmias, Cardiac; Bl | 2001 |
Painful peripheral states and sympathetic blocks.
Topics: Anesthesia, Local; Bupivacaine; Central Nervous System Diseases; Differential Threshold; Female; Gua | 1978 |