Page last updated: 2024-10-23

bupivacaine and Cardiovascular Diseases

bupivacaine has been researched along with Cardiovascular Diseases in 13 studies

Bupivacaine: A widely used local anesthetic agent.
1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide : A piperidinecarboxamide obtained by formal condensation of the carboxy group of N-butylpipecolic acid with the amino group of 2,6-dimethylaniline.
bupivacaine : A racemate composed of equimolar amounts of dextrobupivacaine and levobupivacaine. Used (in the form of its hydrochloride hydrate) as a local anaesthetic.

Cardiovascular Diseases: Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM.

Research Excerpts

Excerpt	Relevance	Reference
" Local anaesthesia is however associated with potential risks and adverse reactions including toxicity."	2.44	Local anaesthetic toxicity. ( Maher, AJ; Metcalfe, SA; Parr, S, 2008)
"Central and regional block procedures have a well-defined role as safe and effective methods in modern anesthesia and analgesia with long-acting local anesthetics."	2.41	The cardiotoxicity of local anesthetics: the place of ropivacaine. ( Graf, BM, 2001)
"We report on a patient with acute pancreatitis whose pain was resistant to simultaneous administration of morphine, procaine and Buscopan."	1.28	[The value of epidural analgesia in acute pancreatitis]. ( Borgeat, A; Chanson, C; Nicolet, A; Schwander, D, 1990)

Research

Studies (13)

Timeframe	Studies, this research(%)	All Research%
pre-1990	3 (23.08)	18.7374
1990's	2 (15.38)	18.2507
2000's	4 (30.77)	29.6817
2010's	4 (30.77)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Ueshima, H	1
Otake, H	1
Yilmaz, M	1
Celebi, H	1
Akcali, D	1
Gurel, N	1
Maher, AJ	1
Metcalfe, SA	1
Parr, S	1
Mather, LE	1
Wolfe, JW	1
Butterworth, JF	2
Baraka, A	1
Srouji, N	1
Haroun, S	1
Brownlow, RC	1
Leith, JP	1
Prielipp, RC	1
Cole, LR	1
Pham-Dang, C	1
Beaumont, S	1
Floch, H	1
Bodin, J	1
Winer, A	1
Pinaud, M	1
Ohmura, S	1
Kawada, M	1
Ohta, T	1
Yamamoto, K	1
Kobayashi, T	1
Graf, BM	1
Borgeat, A	1
Nicolet, A	1
Chanson, C	1
Schwander, D	1
Covino, BG	1
Nolte, H	1
Meyer, J	1

Clinical Trials (6)

Trial Overview

Trial	Phase	Enrollment	Study Type	Start Date	Status
Fractional Carbon Dioxide Laser Assisted Delivery of Topical Anesthetics: a Randomized Controlled Pilot Study[NCT02246179]	Phase 4	10 participants (Actual)	Interventional	2014-09-30	Completed
Parameters in Fractional Laser Assisted Delivery of Topical Anesthetics: Role of Anesthetic and Application Time[NCT03279757]	Phase 4	15 participants (Actual)	Interventional	2016-10-01	Completed
Parameters in Fractional Laser Assisted Delivery of Topical Anesthetics: Role of Laser Type and Laser Settings[NCT02938286]	Phase 4	15 participants (Actual)	Interventional	2016-03-31	Completed
Fractional CO2 Laser Assisted Topical Articaine Anesthesia vs. Topical EMLA Administration: a Randomized Controlled Study[NCT02548533]	Phase 4	3 participants (Actual)	Interventional	2015-06-30	Terminated (stopped due to Not enough patients eligible for recruitment.)
Prospective Randomized Trial of Penile Nerve Block With Liposomal Bupivacaine for Hypospadias Repair vs Standard Penile Block With Bupivacaine[NCT04479371]	Phase 1	0 participants (Actual)	Interventional	2021-07-31	Withdrawn (stopped due to Limited funding and resources to complete FDA requirements for enrollment)
Use of Preemptive Pudendal Nerve Block Prior to Hydrodistension for the Treatment of Interstitial Cystitis/Painful Bladder Syndrome (IC/PBS): a Prospective, Double-blinded, Randomized Control Trial[NCT02517996]		18 participants (Actual)	Interventional	2015-02-28	Terminated (stopped due to Preliminary results were promising when interim analysis performed but terminated due to primary investigators left recruitment site.)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Change in IC Symptom Index Questionnaire With Preemptive Pudendal Nerve Block Compared to Saline

"To determine the change in interstitial cystitis symptom index at baseline, 2 hours, 2 weeks, 6 weeks and 3 months after hydrodistention with preemptive pudendal nerve block (1% Lidocaine) compared to hydrodistention with placebo (saline).~The IC symptom index questionnaire consists of 4 questions on IC symptoms. 2 of the questions have 6 answer choices ranging from 0-never, to 5-almost always. 1 question has 6 answer choices ranging from 0-never to 5-usually. 1 question has 7 answer choices ranging from 0-never to 6-5 or more times. The numerical score for each question are added together, with a minimum score of 0 and a maximum score of 21. A higher score indicates greater severity of IC symptoms." (NCT02517996)
Timeframe: Baseline, 2 weeks, 6 weeks, 3 months (Up to 3 months)

Intervention	score on a scale (Mean)
	Baseline	2 weeks	6 weeks	12 weeks
1% Lidocaine	12.5	11.43	11.8	10
Normal Saline	10	9	8.67	5

Change in Pain Level as Assessed by the Visual Analog Scale (VAS)

"To determine the change in pain at 2 hours, 2 weeks, 6 weeks, and 3 months postoperatively in patients undergoing hydrodistention with preemptive pudendal nerve block (1% Lidocaine) compared to hydrodistention with placebo (saline) using the visual analog scale (VAS).~VAS consists of a 10cm horizontal line with the minimum endpoint labeled no pain (0) and maximum labeled worst pain ever (10). Patients placed a mark on the point that corresponds to the level of pain severity they felt. The cm distance from the low end of the VAS to the patient's mark is used as the numerical index of the intensity of pain. Pain scores of 3.0-5.4 cm are moderate, over 5.4 indicates severe pain." (NCT02517996)
Timeframe: Baseline, 2 hours, 2 weeks, 6 weeks, 3 months (Up to 3 months)

Intervention	score on a scale (Mean)
	Pre operative VAS score	Post operative VAS score	2 week post operative VAS scores	6 week post operative VAS score	12 weeks post operative VAS score
1% Lidocaine	3.125	3.75	2.7	3	2.6
Normal Saline	4.5	5	4.8	4.33	2

Change in Pelvic Urgency, Pain, and Frequency (PUF) Questionnaire With Preemptive Pudendal Nerve Block Compared to Saline

"To determine the change in pelvic urgency, pain and frequency (PUF) questionnaire at baseline, 2 hours, 2 weeks, 6 weeks and 3 months after hydrodistention with preemptive pudendal nerve block (1% Lidocaine) compared to hydrodistention with placebo (saline).~The Pelvic Urgency, Pain, and Frequency Patient Symptom Scale asks 11 questions, 7 on PUF symptoms, 4 on how bothersome PUF symptoms are. Symptom questions include 3, 4, or 5 ranked answers, with higher answers indicating more voids, or greater frequency of pain. The bother questions each of 4 ranked answers from 0-never, to 3-always. The symptom score is added, the bother score is added, and then the total score is added. The total PUF score is then reported. The minimum score is 0 and the maximum score is 35, and a higher score indicates greater symptoms and higher bother from pelvic pain and frequency." (NCT02517996)
Timeframe: Baseline, 2 hours, 2 weeks, 6 weeks, 3 months (Up to 3 months)

Intervention	score on a scale (Mean)
	Baseline	2 weeks	6 weeks	12 weeks
1% Lidocaine	22.63	18.83	18.2	17.2
Normal Saline	19	17.4	16.7	14

Change in Problem Index (O'Leary Sant) With Preemptive Pudendal Nerve Block Compared to Saline

"To determine the change in problem index (O'Leary Sant) at baseline, 2 hours, 2 weeks, 6 weeks and 3 months after hydrodistention with preemptive pudendal nerve block (1% Lidocaine) compared to hydrodistention with placebo (saline).~The IC problem index questionnaire consists of 4 questions on how much of a problem a patient's IC symptoms cause them. Each question has 5 answer choices ranging from 0-no problem, to 4-big problem. The numerical score for each question are added together, with a minimum score of 0 and a maximum score of 16. A higher score indicates that IC symptoms cause more problems for the patient." (NCT02517996)
Timeframe: Baseline, 2 hours, 2 weeks, 6 weeks, 3 months (Up to 3 months)

Intervention	score on a scale (Mean)
	Baseline	2 weeks	6 weeks	12 weeks
1% Lidocaine	11.75	9.71	10	9.6
Normal Saline	9.43	8.6	7.33	6

Reviews

5 reviews available for bupivacaine and Cardiovascular Diseases

Article	Year
Local anaesthetic toxicity. Foot (Edinburgh, Scotland), 2008, Volume: 18, Issue:4 Topics: Amides; Anesthetics, Local; Bupivacaine; Cardiovascular Diseases; Central Nervous System Diseases; H	2008
The acute toxicity of local anesthetics. Expert opinion on drug metabolism & toxicology, 2010, Volume: 6, Issue:11 Topics: Amides; Anesthetics, Local; Animals; Bupivacaine; Cardiovascular Diseases; Central Nervous System Di	2010
Local anesthetic systemic toxicity: update on mechanisms and treatment. Current opinion in anaesthesiology, 2011, Volume: 24, Issue:5 Topics: Anesthesia, Local; Anesthetics, Local; Animals; Bupivacaine; Cardiovascular Diseases; Disease Models	2011
Local anesthetic systemic toxicity: update on mechanisms and treatment. Current opinion in anaesthesiology, 2011, Volume: 24, Issue:5 Topics: Anesthesia, Local; Anesthetics, Local; Animals; Bupivacaine; Cardiovascular Diseases; Disease Models	2011
Local anesthetic systemic toxicity: update on mechanisms and treatment. Current opinion in anaesthesiology, 2011, Volume: 24, Issue:5 Topics: Anesthesia, Local; Anesthetics, Local; Animals; Bupivacaine; Cardiovascular Diseases; Disease Models	2011
Local anesthetic systemic toxicity: update on mechanisms and treatment. Current opinion in anaesthesiology, 2011, Volume: 24, Issue:5 Topics: Anesthesia, Local; Anesthetics, Local; Animals; Bupivacaine; Cardiovascular Diseases; Disease Models	2011
Local anesthetic systemic toxicity: update on mechanisms and treatment. Current opinion in anaesthesiology, 2011, Volume: 24, Issue:5 Topics: Anesthesia, Local; Anesthetics, Local; Animals; Bupivacaine; Cardiovascular Diseases; Disease Models	2011
Local anesthetic systemic toxicity: update on mechanisms and treatment. Current opinion in anaesthesiology, 2011, Volume: 24, Issue:5 Topics: Anesthesia, Local; Anesthetics, Local; Animals; Bupivacaine; Cardiovascular Diseases; Disease Models	2011
Local anesthetic systemic toxicity: update on mechanisms and treatment. Current opinion in anaesthesiology, 2011, Volume: 24, Issue:5 Topics: Anesthesia, Local; Anesthetics, Local; Animals; Bupivacaine; Cardiovascular Diseases; Disease Models	2011
Local anesthetic systemic toxicity: update on mechanisms and treatment. Current opinion in anaesthesiology, 2011, Volume: 24, Issue:5 Topics: Anesthesia, Local; Anesthetics, Local; Animals; Bupivacaine; Cardiovascular Diseases; Disease Models	2011
Local anesthetic systemic toxicity: update on mechanisms and treatment. Current opinion in anaesthesiology, 2011, Volume: 24, Issue:5 Topics: Anesthesia, Local; Anesthetics, Local; Animals; Bupivacaine; Cardiovascular Diseases; Disease Models	2011
Local anesthetic systemic toxicity: update on mechanisms and treatment. Current opinion in anaesthesiology, 2011, Volume: 24, Issue:5 Topics: Anesthesia, Local; Anesthetics, Local; Animals; Bupivacaine; Cardiovascular Diseases; Disease Models	2011
Local anesthetic systemic toxicity: update on mechanisms and treatment. Current opinion in anaesthesiology, 2011, Volume: 24, Issue:5 Topics: Anesthesia, Local; Anesthetics, Local; Animals; Bupivacaine; Cardiovascular Diseases; Disease Models	2011
Local anesthetic systemic toxicity: update on mechanisms and treatment. Current opinion in anaesthesiology, 2011, Volume: 24, Issue:5 Topics: Anesthesia, Local; Anesthetics, Local; Animals; Bupivacaine; Cardiovascular Diseases; Disease Models	2011
Local anesthetic systemic toxicity: update on mechanisms and treatment. Current opinion in anaesthesiology, 2011, Volume: 24, Issue:5 Topics: Anesthesia, Local; Anesthetics, Local; Animals; Bupivacaine; Cardiovascular Diseases; Disease Models	2011
Local anesthetic systemic toxicity: update on mechanisms and treatment. Current opinion in anaesthesiology, 2011, Volume: 24, Issue:5 Topics: Anesthesia, Local; Anesthetics, Local; Animals; Bupivacaine; Cardiovascular Diseases; Disease Models	2011
Local anesthetic systemic toxicity: update on mechanisms and treatment. Current opinion in anaesthesiology, 2011, Volume: 24, Issue:5 Topics: Anesthesia, Local; Anesthetics, Local; Animals; Bupivacaine; Cardiovascular Diseases; Disease Models	2011
Local anesthetic systemic toxicity: update on mechanisms and treatment. Current opinion in anaesthesiology, 2011, Volume: 24, Issue:5 Topics: Anesthesia, Local; Anesthetics, Local; Animals; Bupivacaine; Cardiovascular Diseases; Disease Models	2011
Local anesthetic systemic toxicity: update on mechanisms and treatment. Current opinion in anaesthesiology, 2011, Volume: 24, Issue:5 Topics: Anesthesia, Local; Anesthetics, Local; Animals; Bupivacaine; Cardiovascular Diseases; Disease Models	2011
Local anesthetic systemic toxicity: update on mechanisms and treatment. Current opinion in anaesthesiology, 2011, Volume: 24, Issue:5 Topics: Anesthesia, Local; Anesthetics, Local; Animals; Bupivacaine; Cardiovascular Diseases; Disease Models	2011
Local anesthetic systemic toxicity: update on mechanisms and treatment. Current opinion in anaesthesiology, 2011, Volume: 24, Issue:5 Topics: Anesthesia, Local; Anesthetics, Local; Animals; Bupivacaine; Cardiovascular Diseases; Disease Models	2011
Local anesthetic systemic toxicity: update on mechanisms and treatment. Current opinion in anaesthesiology, 2011, Volume: 24, Issue:5 Topics: Anesthesia, Local; Anesthetics, Local; Animals; Bupivacaine; Cardiovascular Diseases; Disease Models	2011
Local anesthetic systemic toxicity: update on mechanisms and treatment. Current opinion in anaesthesiology, 2011, Volume: 24, Issue:5 Topics: Anesthesia, Local; Anesthetics, Local; Animals; Bupivacaine; Cardiovascular Diseases; Disease Models	2011
Local anesthetic systemic toxicity: update on mechanisms and treatment. Current opinion in anaesthesiology, 2011, Volume: 24, Issue:5 Topics: Anesthesia, Local; Anesthetics, Local; Animals; Bupivacaine; Cardiovascular Diseases; Disease Models	2011
Local anesthetic systemic toxicity: update on mechanisms and treatment. Current opinion in anaesthesiology, 2011, Volume: 24, Issue:5 Topics: Anesthesia, Local; Anesthetics, Local; Animals; Bupivacaine; Cardiovascular Diseases; Disease Models	2011
Local anesthetic systemic toxicity: update on mechanisms and treatment. Current opinion in anaesthesiology, 2011, Volume: 24, Issue:5 Topics: Anesthesia, Local; Anesthetics, Local; Animals; Bupivacaine; Cardiovascular Diseases; Disease Models	2011
Local anesthetic systemic toxicity: update on mechanisms and treatment. Current opinion in anaesthesiology, 2011, Volume: 24, Issue:5 Topics: Anesthesia, Local; Anesthetics, Local; Animals; Bupivacaine; Cardiovascular Diseases; Disease Models	2011
Local anesthetic systemic toxicity: update on mechanisms and treatment. Current opinion in anaesthesiology, 2011, Volume: 24, Issue:5 Topics: Anesthesia, Local; Anesthetics, Local; Animals; Bupivacaine; Cardiovascular Diseases; Disease Models	2011
Local anesthetic systemic toxicity: update on mechanisms and treatment. Current opinion in anaesthesiology, 2011, Volume: 24, Issue:5 Topics: Anesthesia, Local; Anesthetics, Local; Animals; Bupivacaine; Cardiovascular Diseases; Disease Models	2011
Local anesthetic systemic toxicity: update on mechanisms and treatment. Current opinion in anaesthesiology, 2011, Volume: 24, Issue:5 Topics: Anesthesia, Local; Anesthetics, Local; Animals; Bupivacaine; Cardiovascular Diseases; Disease Models	2011
Local anesthetic systemic toxicity: update on mechanisms and treatment. Current opinion in anaesthesiology, 2011, Volume: 24, Issue:5 Topics: Anesthesia, Local; Anesthetics, Local; Animals; Bupivacaine; Cardiovascular Diseases; Disease Models	2011
Local anesthetic systemic toxicity: update on mechanisms and treatment. Current opinion in anaesthesiology, 2011, Volume: 24, Issue:5 Topics: Anesthesia, Local; Anesthetics, Local; Animals; Bupivacaine; Cardiovascular Diseases; Disease Models	2011
Local anesthetic systemic toxicity: update on mechanisms and treatment. Current opinion in anaesthesiology, 2011, Volume: 24, Issue:5 Topics: Anesthesia, Local; Anesthetics, Local; Animals; Bupivacaine; Cardiovascular Diseases; Disease Models	2011
Local anesthetic systemic toxicity: update on mechanisms and treatment. Current opinion in anaesthesiology, 2011, Volume: 24, Issue:5 Topics: Anesthesia, Local; Anesthetics, Local; Animals; Bupivacaine; Cardiovascular Diseases; Disease Models	2011
Local anesthetic systemic toxicity: update on mechanisms and treatment. Current opinion in anaesthesiology, 2011, Volume: 24, Issue:5 Topics: Anesthesia, Local; Anesthetics, Local; Animals; Bupivacaine; Cardiovascular Diseases; Disease Models	2011
Local anesthetic systemic toxicity: update on mechanisms and treatment. Current opinion in anaesthesiology, 2011, Volume: 24, Issue:5 Topics: Anesthesia, Local; Anesthetics, Local; Animals; Bupivacaine; Cardiovascular Diseases; Disease Models	2011
Local anesthetic systemic toxicity: update on mechanisms and treatment. Current opinion in anaesthesiology, 2011, Volume: 24, Issue:5 Topics: Anesthesia, Local; Anesthetics, Local; Animals; Bupivacaine; Cardiovascular Diseases; Disease Models	2011
Local anesthetic systemic toxicity: update on mechanisms and treatment. Current opinion in anaesthesiology, 2011, Volume: 24, Issue:5 Topics: Anesthesia, Local; Anesthetics, Local; Animals; Bupivacaine; Cardiovascular Diseases; Disease Models	2011
The cardiotoxicity of local anesthetics: the place of ropivacaine. Current topics in medicinal chemistry, 2001, Volume: 1, Issue:3 Topics: Action Potentials; Amides; Anesthetics, Local; Animals; Bupivacaine; Cardiovascular Diseases; Centra	2001
Recent advances in local anaesthesia. Canadian Anaesthetists' Society journal, 1986, Volume: 33, Issue:3 Pt 2 Topics: Acidosis; Anesthesia, Local; Anesthetics, Local; Animals; Arrhythmias, Cardiac; Bupivacaine; Cardiov	1986

Other Studies

8 other studies available for bupivacaine and Cardiovascular Diseases

Article	Year
Supra-inguinal fascia iliaca block under ultrasound guidance for perioperative analgesia during bipolar hip arthroplasty in a patient with severe cardiovascular compromise: A case report. Medicine, 2018, Volume: 97, Issue:40 Topics: Aged; Analgesia; Anesthetics, Local; Arthroplasty, Replacement, Hip; Bupivacaine; Cardiovascular Dis	2018
Pre-treatment of bupivacaine-induced cardiovascular depression using different lipid formulations of propofol. Acta anaesthesiologica Scandinavica, 2014, Volume: 58, Issue:3 Topics: Anesthetics, Intravenous; Anesthetics, Local; Animals; Blood Pressure; Bupivacaine; Cardiovascular D	2014
Cardiovascular collapse following intercostal block with bupivacaine in a patient under general anesthesia. Middle East journal of anaesthesiology, 1983, Volume: 7, Issue:3 Topics: Anesthesia, General; Bupivacaine; Cardiovascular Diseases; Female; Humans; Intercostal Nerves; Middl	1983
Bupivacaine inhibits cyclic-3',5'-adenosine monophosphate production. A possible contributing factor to cardiovascular toxicity. Anesthesiology, 1993, Volume: 79, Issue:1 Topics: Adenylyl Cyclases; Adult; Amides; Bupivacaine; Cardiovascular Diseases; Colforsin; Cyclic AMP; Drug	1993
[Acute toxic accident following lumbar plexus block with bupivacaine]. Annales francaises d'anesthesie et de reanimation, 2000, Volume: 19, Issue:5 Topics: Anesthesia, Spinal; Anesthetics, Local; Arthroplasty, Replacement, Hip; Bupivacaine; Cardiopulmonary	2000
Systemic toxicity and resuscitation in bupivacaine-, levobupivacaine-, or ropivacaine-infused rats. Anesthesia and analgesia, 2001, Volume: 93, Issue:3 Topics: Adrenergic alpha-Agonists; Amides; Anesthesia; Anesthetics, Local; Animals; Arrhythmias, Cardiac; Bl	2001
[The value of epidural analgesia in acute pancreatitis]. Schweizerische medizinische Wochenschrift, 1990, Feb-03, Volume: 120, Issue:5 Topics: Analgesia, Epidural; Bupivacaine; Cardiovascular Diseases; Drug Therapy, Combination; Fentanyl; Huma	1990
[The possibilities of indications for regional anaesthesia]. Der Anaesthesist, 1972, Volume: 21, Issue:3 Topics: Ambulatory Care; Anesthesia, Conduction; Anesthesia, Obstetrical; Anesthetics, Local; Angiography; B	1972