bupivacaine has been researched along with Cardiotoxicity in 27 studies
Bupivacaine: A widely used local anesthetic agent.
1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide : A piperidinecarboxamide obtained by formal condensation of the carboxy group of N-butylpipecolic acid with the amino group of 2,6-dimethylaniline.
bupivacaine : A racemate composed of equimolar amounts of dextrobupivacaine and levobupivacaine. Used (in the form of its hydrochloride hydrate) as a local anaesthetic.
Cardiotoxicity: Damage to the HEART or its function secondary to exposure to toxic substances such as drugs used in CHEMOTHERAPY; IMMUNOTHERAPY; or RADIATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Efforts to develop a treatment for bupivacaine cardiotoxicity led to the discovery that Intralipid, a popular brand of intravenous lipid emulsion, could be used not only as an effective treatment for anesthetic-induced cardiac arrest, but also as a means of reversing many other toxicities." | 8.95 | Lipid Emulsion, More Than Reversing Bupivacaine Cardiotoxicity: Potential Organ Protection. ( Atala, A; Motayagheni, N; Nozari, A; Phan, S, 2017) |
| "Cardiotoxicity can be induced by the commonly used amide local anesthetic, bupivacaine." | 8.02 | Apelin-13 Reverses Bupivacaine-Induced Cardiotoxicity via the Adenosine Monophosphate-Activated Protein Kinase Pathway. ( Cai, Y; Chen, H; Jin, Z; Liu, L; Papadimos, TJ; Shi, K; Wang, Q; Xia, E; Xia, F; Xia, Y; Xu, X; Ye, Y, 2021) |
| " On that basis, we constructed a large virtual population of rats (N = 10,000) undergoing lipid therapy following bupivacaine cardiotoxicity." | 8.02 | Predicting Inter-individual Variability During Lipid Resuscitation of Bupivacaine Cardiotoxicity in Rats: A Virtual Population Modeling Study. ( Akpa, BS; Flores, KB; McDaniel, M, 2021) |
| "The relative efficacies of a long- and medium-chain triglyceride (LCT/MCT) emulsion and an LCT emulsion for treatment of bupivacaine (BPV)-induced cardiac toxicity are poorly defined." | 7.96 | Lipid Emulsion Restoration of Myocardial Contractions After Bupivacaine-Induced Asystole In Vitro: A Benefit of Long- and Medium-Chain Triglyceride Over Long-Chain Triglyceride. ( Jung, JR; Kim, HJ; Kim, HS; Kim, HY; Lynch, C; Park, WK, 2020) |
| "Dexmedetomidine was proved to mitigate bupivacaine-induced cardiotoxicity but mechanism of this ability is still unclear." | 7.91 | Dexmedetomidine enhances tolerance to bupivacaine cardiotoxicity in the isolated rat hearts: alpha 2 adrenoceptors were not involved. ( Cai, X; Cai, Y; Chen, H; Jin, Z; Lin, T; Pan, L; Wang, S; Xia, F, 2019) |
| "Bupivacaine cardiotoxicity rapidly dephosphorylated Akt at S473 to 63 ± 5% of baseline and phosphorylated AMPK to 151 ± 19%." | 7.83 | Insulin Signaling in Bupivacaine-induced Cardiac Toxicity: Sensitization during Recovery and Potentiation by Lipid Emulsion. ( Bonini, M; Fettiplace, MR; Kowal, K; Lis, K; Minshall, R; Ripper, R; Rubinstein, I; Weinberg, G; Young, A, 2016) |
| " However, to our knowledge, it remains unknown whether EA could alleviate bupivacaine-induced cardiotoxicity." | 7.83 | Electroacupuncture pretreatment induces rapid tolerance to bupivacaine cardiotoxicity in rats. ( Gao, JL; Han, FF; Li, XX; Li, YL; Wang, XM; Zhang, DH; Zhang, HJ; Zhao, QL, 2016) |
| "Time of arrhythmia, 50% mean arterial pressure- and 50% heart rate-reduction, and asystole were recorded, and ropivacaine doses were calculated." | 5.72 | Effects of nalbuphine on the cardiotoxicity of ropivacaine in rats. ( Huang, S; Jiao, J; Sun, S; Wang, C; Yu, X, 2022) |
| "Bupivacaine is an amide local anesthetic with possible side effects that include an irregular heart rate." | 5.56 | The anesthetic bupivacaine induces cardiotoxicity by targeting L-type voltage-dependent calcium channels. ( Chen, B; Gao, Y; Hua, Q; Li, B; Yang, R; Zhang, X, 2020) |
| "Remifentanil is a selective, ultra-short-acting, µ-opioid receptor agonist opioid." | 5.48 | Effects of Remifentanil Pretreatment on Bupivacaine Cardiotoxicity in Rats. ( Ayoğlu, H; Pişkin, Ö, 2018) |
| "Efforts to develop a treatment for bupivacaine cardiotoxicity led to the discovery that Intralipid, a popular brand of intravenous lipid emulsion, could be used not only as an effective treatment for anesthetic-induced cardiac arrest, but also as a means of reversing many other toxicities." | 4.95 | Lipid Emulsion, More Than Reversing Bupivacaine Cardiotoxicity: Potential Organ Protection. ( Atala, A; Motayagheni, N; Nozari, A; Phan, S, 2017) |
| " Albright, MD (1931-2020) published a controversial editorial in Anesthesiology that raised the question of bupivacaine cardiotoxicity." | 4.12 | The Bupivacaine Story: A Tribute to George A. Albright, MD (1931-2020). ( Larson, CP; Moon, JS; Youssefzadeh, K, 2022) |
| "Our data illustrate differences in calcium dynamics between anesthetics and how calcium may mitigate bupivacaine cardiotoxicity." | 4.12 | Local Anesthetic Cardiac Toxicity Is Mediated by Cardiomyocyte Calcium Dynamics. ( Coles, JG; Estrada, M; Lonnqvist, PA; Maynes, JT; Plakhotnik, J; Zhang, L, 2022) |
| "Cardiotoxicity can be induced by the commonly used amide local anesthetic, bupivacaine." | 4.02 | Apelin-13 Reverses Bupivacaine-Induced Cardiotoxicity via the Adenosine Monophosphate-Activated Protein Kinase Pathway. ( Cai, Y; Chen, H; Jin, Z; Liu, L; Papadimos, TJ; Shi, K; Wang, Q; Xia, E; Xia, F; Xia, Y; Xu, X; Ye, Y, 2021) |
| " On that basis, we constructed a large virtual population of rats (N = 10,000) undergoing lipid therapy following bupivacaine cardiotoxicity." | 4.02 | Predicting Inter-individual Variability During Lipid Resuscitation of Bupivacaine Cardiotoxicity in Rats: A Virtual Population Modeling Study. ( Akpa, BS; Flores, KB; McDaniel, M, 2021) |
| "The relative efficacies of a long- and medium-chain triglyceride (LCT/MCT) emulsion and an LCT emulsion for treatment of bupivacaine (BPV)-induced cardiac toxicity are poorly defined." | 3.96 | Lipid Emulsion Restoration of Myocardial Contractions After Bupivacaine-Induced Asystole In Vitro: A Benefit of Long- and Medium-Chain Triglyceride Over Long-Chain Triglyceride. ( Jung, JR; Kim, HJ; Kim, HS; Kim, HY; Lynch, C; Park, WK, 2020) |
| "Dexmedetomidine was proved to mitigate bupivacaine-induced cardiotoxicity but mechanism of this ability is still unclear." | 3.91 | Dexmedetomidine enhances tolerance to bupivacaine cardiotoxicity in the isolated rat hearts: alpha 2 adrenoceptors were not involved. ( Cai, X; Cai, Y; Chen, H; Jin, Z; Lin, T; Pan, L; Wang, S; Xia, F, 2019) |
| "Lipid emulsion (LE) therapy has been used to reduce overdose of bupivacaine (BPV)-induced cardiotoxicity." | 3.91 | Involvement of TREK-1 Channel in Cell Viability of H9c2 Rat Cardiomyoblasts Affected by Bupivacaine and Lipid Emulsion. ( Han, J; Kang, D; Kim, EJ; Kim, JW; Nyiramana, MM; Shin, EJ; Siregar, AS; Sohn, JT; Yang, JH, 2019) |
| "Bupivacaine cardiotoxicity mainly manifests as inhibition of the cardiac sodium channel, which slows conduction, particularly at the ventricular level." | 3.91 | Comparative Effects of Sodium Bicarbonate and Intravenous Lipid Emulsions on Reversing Bupivacaine-Induced Electrophysiological Toxicity in a Porcine Experimental Model. ( Almendral, J; Anadón Baselga, MJ; Callejo, D; López-Menchaca, R; Melone, A; Quintela, O; Sevilla, R; Varela, O; Zaballos, M, 2019) |
| "In order to determine the role of the adrenergic system in bupivacaine-induced cardiotoxicity, a series of experiments were performed." | 3.88 | Beta-adrenergic activation induces cardiac collapse by aggravating cardiomyocyte contractile dysfunction in bupivacaine intoxication. ( Chen, Y; Cheng, Y; Chu, L; Duan, R; Li, H; Li, J; Xia, D; Yuan, J; Zhang, J; Zhang, Y; Zhao, S; Zhao, X, 2018) |
| "Bupivacaine cardiotoxicity rapidly dephosphorylated Akt at S473 to 63 ± 5% of baseline and phosphorylated AMPK to 151 ± 19%." | 3.83 | Insulin Signaling in Bupivacaine-induced Cardiac Toxicity: Sensitization during Recovery and Potentiation by Lipid Emulsion. ( Bonini, M; Fettiplace, MR; Kowal, K; Lis, K; Minshall, R; Ripper, R; Rubinstein, I; Weinberg, G; Young, A, 2016) |
| " However, to our knowledge, it remains unknown whether EA could alleviate bupivacaine-induced cardiotoxicity." | 3.83 | Electroacupuncture pretreatment induces rapid tolerance to bupivacaine cardiotoxicity in rats. ( Gao, JL; Han, FF; Li, XX; Li, YL; Wang, XM; Zhang, DH; Zhang, HJ; Zhao, QL, 2016) |
| "A commercially available lipid emulsion was able to delay progression of cocaine cardiac toxicity in vivo." | 3.81 | Cardiac depression induced by cocaine or cocaethylene is alleviated by lipid emulsion more effectively than by sulfobutylether-β-cyclodextrin. ( Feinstein, DL; Fettiplace, MR; Kowal, K; Lin, B; Lis, K; Pichurko, A; Ripper, R; Rubinstein, I; Schwartz, D; Weinberg, G, 2015) |
| "Time of arrhythmia, 50% mean arterial pressure- and 50% heart rate-reduction, and asystole were recorded, and ropivacaine doses were calculated." | 1.72 | Effects of nalbuphine on the cardiotoxicity of ropivacaine in rats. ( Huang, S; Jiao, J; Sun, S; Wang, C; Yu, X, 2022) |
| "Bupivacaine is an amide local anesthetic with possible side effects that include an irregular heart rate." | 1.56 | The anesthetic bupivacaine induces cardiotoxicity by targeting L-type voltage-dependent calcium channels. ( Chen, B; Gao, Y; Hua, Q; Li, B; Yang, R; Zhang, X, 2020) |
| "Remifentanil is a selective, ultra-short-acting, µ-opioid receptor agonist opioid." | 1.48 | Effects of Remifentanil Pretreatment on Bupivacaine Cardiotoxicity in Rats. ( Ayoğlu, H; Pişkin, Ö, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 19 (70.37) | 24.3611 |
| 2020's | 8 (29.63) | 2.80 |
| Authors | Studies |
|---|---|
| Ye, Y | 1 |
| Cai, Y | 3 |
| Xia, E | 1 |
| Shi, K | 1 |
| Jin, Z | 3 |
| Chen, H | 3 |
| Xia, F | 3 |
| Xia, Y | 1 |
| Papadimos, TJ | 1 |
| Xu, X | 1 |
| Liu, L | 1 |
| Wang, Q | 1 |
| Wang, C | 1 |
| Sun, S | 1 |
| Jiao, J | 1 |
| Yu, X | 1 |
| Huang, S | 1 |
| Larson, CP | 1 |
| Youssefzadeh, K | 1 |
| Moon, JS | 1 |
| Plakhotnik, J | 1 |
| Zhang, L | 1 |
| Estrada, M | 1 |
| Coles, JG | 1 |
| Lonnqvist, PA | 1 |
| Maynes, JT | 1 |
| Lin, T | 1 |
| Cai, X | 1 |
| Pan, L | 1 |
| Wang, S | 1 |
| Kim, HJ | 1 |
| Kim, HS | 1 |
| Jung, JR | 1 |
| Kim, HY | 1 |
| Lynch, C | 1 |
| Park, WK | 1 |
| Gao, Y | 1 |
| Chen, B | 1 |
| Zhang, X | 1 |
| Yang, R | 1 |
| Hua, Q | 1 |
| Li, B | 1 |
| Chen, X | 2 |
| McDaniel, M | 1 |
| Flores, KB | 1 |
| Akpa, BS | 2 |
| Pişkin, Ö | 2 |
| Ayoğlu, H | 1 |
| Aydın, BG | 1 |
| Motayagheni, N | 1 |
| Phan, S | 1 |
| Nozari, A | 1 |
| Atala, A | 1 |
| Li, J | 1 |
| Duan, R | 1 |
| Zhang, Y | 1 |
| Zhao, X | 1 |
| Cheng, Y | 1 |
| Chen, Y | 1 |
| Yuan, J | 1 |
| Li, H | 1 |
| Zhang, J | 1 |
| Chu, L | 1 |
| Xia, D | 1 |
| Zhao, S | 1 |
| Lim, DH | 1 |
| Sohn, JT | 3 |
| Yang, JH | 1 |
| Siregar, AS | 1 |
| Kim, EJ | 1 |
| Nyiramana, MM | 1 |
| Shin, EJ | 1 |
| Han, J | 1 |
| Kim, JW | 1 |
| Kang, D | 1 |
| Zaballos, M | 1 |
| Callejo, D | 1 |
| Sevilla, R | 1 |
| Quintela, O | 1 |
| López-Menchaca, R | 1 |
| Melone, A | 1 |
| Varela, O | 1 |
| Anadón Baselga, MJ | 1 |
| Almendral, J | 1 |
| Lemoine, S | 1 |
| Rouet, R | 1 |
| Manrique, A | 1 |
| Hanouz, JL | 1 |
| Fettiplace, MR | 3 |
| Lis, K | 3 |
| Ripper, R | 3 |
| Kowal, K | 3 |
| Pichurko, A | 2 |
| Vitello, D | 1 |
| Rubinstein, I | 3 |
| Schwartz, D | 2 |
| Weinberg, G | 3 |
| Park, K | 1 |
| Lin, B | 1 |
| Feinstein, DL | 1 |
| Yang, L | 1 |
| Bai, Z | 1 |
| Lv, D | 1 |
| Liu, H | 1 |
| Li, X | 1 |
| Ok, SH | 1 |
| Yu, J | 1 |
| Lee, Y | 1 |
| Cho, H | 1 |
| Shin, IW | 1 |
| Hori, K | 1 |
| Matsuura, T | 1 |
| Tsujikawa, S | 1 |
| Mori, T | 1 |
| Kuno, M | 1 |
| Nishikawa, K | 1 |
| Young, A | 1 |
| Bonini, M | 1 |
| Minshall, R | 1 |
| Yu, RN | 1 |
| Houck, CS | 1 |
| Casta, A | 1 |
| Blum, RH | 1 |
| Gao, JL | 1 |
| Li, YL | 1 |
| Wang, XM | 1 |
| Zhao, QL | 1 |
| Zhang, HJ | 1 |
| Han, FF | 1 |
| Li, XX | 1 |
| Zhang, DH | 1 |
| Wong, GK | 1 |
| Pehora, C | 1 |
| Crawford, MW | 1 |
1 review available for bupivacaine and Cardiotoxicity
| Article | Year |
|---|---|
Lipid Emulsion, More Than Reversing Bupivacaine Cardiotoxicity: Potential Organ Protection.
Topics: Animals; Bupivacaine; Cardiotoxicity; Emulsions; Fat Emulsions, Intravenous; Heart; Hemodynamics; Hu | 2017 |
26 other studies available for bupivacaine and Cardiotoxicity
| Article | Year |
|---|---|
Apelin-13 Reverses Bupivacaine-Induced Cardiotoxicity via the Adenosine Monophosphate-Activated Protein Kinase Pathway.
Topics: AMP-Activated Protein Kinases; Animals; Bupivacaine; Cardiotoxicity; Cell Line; Disease Models, Anim | 2021 |
Effects of nalbuphine on the cardiotoxicity of ropivacaine in rats.
Topics: Amides; Anesthetics, Local; Animals; Arrhythmias, Cardiac; Bupivacaine; Cardiotoxicity; Heart Arrest | 2022 |
The Bupivacaine Story: A Tribute to George A. Albright, MD (1931-2020).
Topics: Amides; Anesthetics, Local; Bupivacaine; Cardiotoxicity; Emulsions; Female; Humans; Lipids; Male; Pr | 2022 |
Local Anesthetic Cardiac Toxicity Is Mediated by Cardiomyocyte Calcium Dynamics.
Topics: Amides; Anesthetics, Local; Animals; Arrhythmias, Cardiac; Bupivacaine; Calcium; Cardiotoxicity; Fem | 2022 |
Dexmedetomidine enhances tolerance to bupivacaine cardiotoxicity in the isolated rat hearts: alpha 2 adrenoceptors were not involved.
Topics: Adrenergic alpha-2 Receptor Agonists; Analgesics, Non-Narcotic; Anesthetics, Local; Animals; Bupivac | 2019 |
Lipid Emulsion Restoration of Myocardial Contractions After Bupivacaine-Induced Asystole In Vitro: A Benefit of Long- and Medium-Chain Triglyceride Over Long-Chain Triglyceride.
Topics: Anesthetics, Local; Animals; Bupivacaine; Cardiotoxicity; Drug Compounding; Energy Metabolism; Fat E | 2020 |
The anesthetic bupivacaine induces cardiotoxicity by targeting L-type voltage-dependent calcium channels.
Topics: Action Potentials; Animals; Bupivacaine; Calcium; Calcium Channels, L-Type; Cardiotoxicity; Rats; Ra | 2020 |
Ablation of small conductance calcium-activated potassium type-2 channel (SK
Topics: Animals; Bupivacaine; Cardiotoxicity; Female; Heart; HEK293 Cells; Humans; Male; Mice, Inbred C57BL; | 2021 |
Predicting Inter-individual Variability During Lipid Resuscitation of Bupivacaine Cardiotoxicity in Rats: A Virtual Population Modeling Study.
Topics: Anesthetics, Local; Animals; Bupivacaine; Cardiotoxicity; Lipids; Rats; Rats, Sprague-Dawley | 2021 |
Effects of Remifentanil Pretreatment on Bupivacaine Cardiotoxicity in Rats.
Topics: Anesthetics, Local; Animals; Antidotes; Arrhythmias, Cardiac; Arterial Pressure; Bupivacaine; Cardio | 2018 |
Effects of insulin+glucose pretreatment on bupivacaine cardiotoxicity in rats.
Topics: Animals; Arterial Pressure; Bupivacaine; Cardiotoxicity; Fat Emulsions, Intravenous; Glucose; Heart | 2018 |
Beta-adrenergic activation induces cardiac collapse by aggravating cardiomyocyte contractile dysfunction in bupivacaine intoxication.
Topics: Anesthesia; Animals; Blood Pressure; Bupivacaine; Cardiotoxicity; Chloral Hydrate; Disease Models, A | 2018 |
Bupivacaine-induced cardiotoxicity and lipid emulsion.
Topics: Anesthetics, Local; Animals; Bupivacaine; Cardiotoxicity; Fat Emulsions, Intravenous; Glucose; Insul | 2019 |
Involvement of TREK-1 Channel in Cell Viability of H9c2 Rat Cardiomyoblasts Affected by Bupivacaine and Lipid Emulsion.
Topics: Animals; Bupivacaine; Cardiotoxicity; Cell Line; Cell Survival; Humans; Lipids; Membrane Potential, | 2019 |
Comparative Effects of Sodium Bicarbonate and Intravenous Lipid Emulsions on Reversing Bupivacaine-Induced Electrophysiological Toxicity in a Porcine Experimental Model.
Topics: Action Potentials; Anesthetics, Local; Animals; Antidotes; Arrhythmias, Cardiac; Bupivacaine; Cardio | 2019 |
Effect of long-chain triglyceride lipid emulsion on bupivacaine-induced changes in electrophysiological parameters of rabbit Purkinje cells.
Topics: Action Potentials; Anesthetics, Local; Animals; Bupivacaine; Cardiotoxicity; Disease Models, Animal; | 2014 |
Multi-modal contributions to detoxification of acute pharmacotoxicity by a triglyceride micro-emulsion.
Topics: Animals; Bupivacaine; Cardiac Output; Cardiotonic Agents; Cardiotoxicity; Cardiotoxins; Emulsions; L | 2015 |
Triglyceride micro-emulsion for detoxification of acute pharmacotoxicity.
Topics: Bupivacaine; Cardiac Output; Cardiotonic Agents; Cardiotoxicity; Cardiotoxins; Emulsions; Phospholip | 2015 |
Cardiac depression induced by cocaine or cocaethylene is alleviated by lipid emulsion more effectively than by sulfobutylether-β-cyclodextrin.
Topics: Animals; Arrhythmias, Cardiac; beta-Cyclodextrins; Bupivacaine; Cardiotoxicity; Cocaine; Coronary Ci | 2015 |
Rescue effect of lipid emulsion on bupivacaine-induced cardiac toxicity in cardiomyocytes.
Topics: Apoptosis; Bupivacaine; Cardiotoxicity; Caspases; Cell Line; Cell Proliferation; Emulsions; Humans; | 2015 |
Lipid emulsion attenuates apoptosis induced by a toxic dose of bupivacaine in H9c2 rat cardiomyoblast cells.
Topics: Anesthetics, Local; Animals; Apoptosis; Bupivacaine; Cardiotoxicity; Cell Line; Cell Survival; Dose- | 2016 |
The significant contribution of the partitioning effect in lipid resuscitation for bupivacaine-induced cardiotoxicity: evaluation using centrifuged solution in vivo and in isolated hearts.
Topics: Anesthetics, Local; Animals; Bupivacaine; Cardiotoxicity; Fat Emulsions, Intravenous; Guinea Pigs; H | 2015 |
Insulin Signaling in Bupivacaine-induced Cardiac Toxicity: Sensitization during Recovery and Potentiation by Lipid Emulsion.
Topics: AMP-Activated Protein Kinases; Anesthesia Recovery Period; Anesthetics, Local; Animals; Blotting, We | 2016 |
Institutional Policy Changes to Prevent Cardiac Toxicity Associated With Bupivacaine Penile Blockade in Infants.
Topics: Anesthetics, Local; Bupivacaine; Cardiotoxicity; Humans; Infant; Male; Nerve Block; Pain, Postoperat | 2016 |
Electroacupuncture pretreatment induces rapid tolerance to bupivacaine cardiotoxicity in rats.
Topics: Anesthetics, Local; Animals; Arrhythmias, Cardiac; Arterial Pressure; Blood Pressure; Bupivacaine; C | 2016 |
L-carnitine reduces susceptibility to bupivacaine-induced cardiotoxicity: an experimental study in rats.
Topics: Animals; Bupivacaine; Cardiotoxicity; Carnitine; Humans; Male; Rats; Rats, Sprague-Dawley | 2017 |