bupivacaine has been researched along with Carcinoma in 4 studies
Bupivacaine: A widely used local anesthetic agent.
1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide : A piperidinecarboxamide obtained by formal condensation of the carboxy group of N-butylpipecolic acid with the amino group of 2,6-dimethylaniline.
bupivacaine : A racemate composed of equimolar amounts of dextrobupivacaine and levobupivacaine. Used (in the form of its hydrochloride hydrate) as a local anaesthetic.
Carcinoma: A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm and not a synonym for cancer.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In this prospective, randomized, placebo-controlled, double-blinded clinical trial we tested the hypothesis that preemptive analgesia with bupivacaine applied in the area of the surgical incision in patients undergoing mastectomy for breast cancer would reduce post-operative acute pain and would reduce the amount of analgesics used during surgery and in the post-operative period." | 9.15 | A randomized, double-blind, placebo-controlled trial of preemptive analgesia with bupivacaine in patients undergoing mastectomy for carcinoma of the breast. ( Irga, N; Jaskiewicz, J; Jaworski, R; Smietanska, I; Wujtewicz, M; Zielinski, J, 2011) |
| "In this prospective, randomized, placebo-controlled, double-blinded clinical trial we tested the hypothesis that preemptive analgesia with bupivacaine applied in the area of the surgical incision in patients undergoing mastectomy for breast cancer would reduce post-operative acute pain and would reduce the amount of analgesics used during surgery and in the post-operative period." | 5.15 | A randomized, double-blind, placebo-controlled trial of preemptive analgesia with bupivacaine in patients undergoing mastectomy for carcinoma of the breast. ( Irga, N; Jaskiewicz, J; Jaworski, R; Smietanska, I; Wujtewicz, M; Zielinski, J, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zielinski, J | 1 |
| Jaworski, R | 1 |
| Smietanska, I | 1 |
| Irga, N | 1 |
| Wujtewicz, M | 1 |
| Jaskiewicz, J | 1 |
| Fikkers, BG | 1 |
| Damen, J | 1 |
| Scheffer, GJ | 1 |
| Kruithof, HC | 1 |
| Bovianska, N | 1 |
| Bleeker, CP | 1 |
| Bremer, RC | 1 |
| Dongelmans, DA | 1 |
| van Dongen, RT | 1 |
| Crul, BJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Pre-Emptive Analgesia in Ano-Rectal Surgery[NCT02402543] | 90 participants (Actual) | Interventional | 2014-06-30 | Completed | |||
| The Use of Liposomal Bupivacaine for Pain Control Following Mastectomy and Breast Reconstruction[NCT03722927] | Phase 4 | 3 participants (Actual) | Interventional | 2018-06-14 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Frequency of postoperative opioid related adverse effects within the first week of surgery will be recorded. This includes nausea, vomiting, pruritus, allergy, respiratory depression. (NCT03722927)
Timeframe: Postoperatively, 1 week
| Intervention | Participants (Count of Participants) |
|---|---|
| Bupivacaine Group | 0 |
| Liposomal Bupivacaine Group | 0 |
The length of stay for hospitalization after mastectomy and breast reconstruction will be recorded. (NCT03722927)
Timeframe: up to 47 Hours
| Intervention | days (Mean) |
|---|---|
| Bupivacaine Group | 1 |
| Liposomal Bupivacaine Group | 1 |
This will be measured by the number of doses within the first month postoperatively and recorded on pain medication daily diary kept by subject. (NCT03722927)
Timeframe: 1 Month
| Intervention | Number of morphine doses (Number) |
|---|---|
| Bupivacaine Group | 0 |
| Liposomal Bupivacaine Group | 20 |
Readmission rates to the hospital within 2 months after mastectomy and breast reconstruction will be recorded (NCT03722927)
Timeframe: Month 2
| Intervention | Participants (Count of Participants) |
|---|---|
| Bupivacaine Group | 0 |
| Liposomal Bupivacaine Group | 0 |
This will be measured every 12 hours for the first 48 hours postoperatively by the level of breast pain associated with arm movements while eating on a scale of 0-10 with higher scores denoting worse outcomes. (NCT03722927)
Timeframe: 48 hours
| Intervention | score on a scale (Mean) |
|---|---|
| 12 hours | |
| Bupivacaine Group | 4 |
This will be measured every 12 hours for the first 48 hours postoperatively by the level of breast pain associated with arm movements while eating on a scale of 0-10 with higher scores denoting worse outcomes. (NCT03722927)
Timeframe: 48 hours
| Intervention | score on a scale (Mean) | |||
|---|---|---|---|---|
| 12 hours | 24 hours | 36 hours | 48 hours | |
| Liposomal Bupivacaine Group | 3.5 | 4 | 3.5 | 2 |
1 trial available for bupivacaine and Carcinoma
| Article | Year |
|---|---|
A randomized, double-blind, placebo-controlled trial of preemptive analgesia with bupivacaine in patients undergoing mastectomy for carcinoma of the breast.
Topics: Analgesia, Patient-Controlled; Anesthetics, Local; Breast Neoplasms; Bupivacaine; Carcinoma; Double- | 2011 |
A randomized, double-blind, placebo-controlled trial of preemptive analgesia with bupivacaine in patients undergoing mastectomy for carcinoma of the breast.
Topics: Analgesia, Patient-Controlled; Anesthetics, Local; Breast Neoplasms; Bupivacaine; Carcinoma; Double- | 2011 |
A randomized, double-blind, placebo-controlled trial of preemptive analgesia with bupivacaine in patients undergoing mastectomy for carcinoma of the breast.
Topics: Analgesia, Patient-Controlled; Anesthetics, Local; Breast Neoplasms; Bupivacaine; Carcinoma; Double- | 2011 |
A randomized, double-blind, placebo-controlled trial of preemptive analgesia with bupivacaine in patients undergoing mastectomy for carcinoma of the breast.
Topics: Analgesia, Patient-Controlled; Anesthetics, Local; Breast Neoplasms; Bupivacaine; Carcinoma; Double- | 2011 |
3 other studies available for bupivacaine and Carcinoma
| Article | Year |
|---|---|
Thoracic epidural analgesia and antihypertensive therapy: a matter of timing?
Topics: Aged; Analgesia, Epidural; Analgesics, Opioid; Anesthetics, Local; Antihypertensive Agents; Bupivaca | 2006 |
[Combined spinal and epidural analgesia in urology].
Topics: Adult; Aged; Analgesia, Epidural; Anesthesia, Spinal; Anesthetics, Local; Bupivacaine; Carcinoma; Fe | 1995 |
Inefficacy of high-dose transdermal fentanyl in a patient with neuropathic pain, a case report.
Topics: Administration, Cutaneous; Analgesia, Epidural; Analgesics, Opioid; Anesthetics, Local; Breast Neopl | 2001 |