Page last updated: 2024-10-24

bupivacaine and Bradyarrhythmia

bupivacaine has been researched along with Bradyarrhythmia in 72 studies

Bupivacaine: A widely used local anesthetic agent.
1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide : A piperidinecarboxamide obtained by formal condensation of the carboxy group of N-butylpipecolic acid with the amino group of 2,6-dimethylaniline.
bupivacaine : A racemate composed of equimolar amounts of dextrobupivacaine and levobupivacaine. Used (in the form of its hydrochloride hydrate) as a local anaesthetic.

Research Excerpts

ExcerptRelevanceReference
"Prophylactic phenylephrine infusion is an effective method of reducing SA-induced hypotension in the elderly."9.22Prophylactic phenylephrine infusion for the prevention of hypotension after spinal anesthesia in the elderly: a randomized controlled clinical trial. ( Bataille, B; Bruneteau, L; Ferré, F; Ferrier, A; Fourcade, O; Gris, C; Kurrek, M; Marty, P; Merlet, V; Minville, V; Sommet, A, 2016)
"To determine if prophylactic glycopyrrolate prevents bradycardia after spinal anesthesia."9.15Prophylactic glycopyrrolate prevents bradycardia after spinal anesthesia for Cesarean section: a randomized, double-blinded, placebo-controlled prospective trial with heart rate variability correlation. ( Aronzon, B; Chamchad, D; Gerson, A; Horrow, JC; Medved, M; Nakhamchik, L; Roberts, N; Sauter, J, 2011)
" The study's objectives were threefold: (i) evaluate the myocardial toxicity of levobupivacaine when administered intravenously; (ii) investigate levobupivacaine toxicity on cardiomyocytes mitochondrial functions and cellular structure; (iii) assess the protective effects of a lipid emulsion in the presence or absence of myocardial ischemia."7.81Electrophysiological, haemodynamic, and mitochondrial alterations induced by levobupivacaine during myocardial ischemia in a pig model: protection by lipid emulsions? ( Bui-Xuan, B; Chevalier, P; Descotes, J; Mamou, Z; Romestaing, C; Timour, Q, 2015)
"The purpose of this study was to determine, by continual reassessment, the 90% effective dose (ED90) of phenylephrine for hypotension after combined spinal-epidural anesthesia."7.81Determination of the 90% effective dose (ED90) of phenylephrine for hypotension during elective cesarean delivery using a continual reassessment method. ( Diao, M; Huang, Y; Li, H; Lin, X; Liu, H; Ma, Y; Zhou, J, 2015)
"Severe hypocapnic alkalosis prolonged the recovery time from 273 +/- 122 sec, at the 1 microg x mL(-1) bupivacaine concentration with normal pH washout, to 1203 +/- 540 sec, in the bupivacaine with hypocapnic alkalosis washout (p = 0."7.74Hypocapnia prolongs bradycardia induced by bupivacaine or levobupivacaine in isolated rat hearts. ( Mochizuki, T; Sato, S, 2008)
"Usage of high dose of heavy bupivacaine and level of blockage higher than T5 were two modifiable risk factors associated with hypotension during spinal anesthesia."7.74Prospective study of hypotension and bradycardia during spinal anesthesia with bupivacaine: incidence and risk factors, part two. ( Chinachoti, T; Tritrakarn, T, 2007)
"His bradycardia was refractory to atropine."5.48Profound Prolonged Bradycardia and Hypotension after Interscalene Brachial Plexus Block with Bupivacaine. ( Lee, D; Nelson, M; Reda, L; Reens, A, 2018)
"Prophylactic phenylephrine infusion is an effective method of reducing SA-induced hypotension in the elderly."5.22Prophylactic phenylephrine infusion for the prevention of hypotension after spinal anesthesia in the elderly: a randomized controlled clinical trial. ( Bataille, B; Bruneteau, L; Ferré, F; Ferrier, A; Fourcade, O; Gris, C; Kurrek, M; Marty, P; Merlet, V; Minville, V; Sommet, A, 2016)
"To determine if prophylactic glycopyrrolate prevents bradycardia after spinal anesthesia."5.15Prophylactic glycopyrrolate prevents bradycardia after spinal anesthesia for Cesarean section: a randomized, double-blinded, placebo-controlled prospective trial with heart rate variability correlation. ( Aronzon, B; Chamchad, D; Gerson, A; Horrow, JC; Medved, M; Nakhamchik, L; Roberts, N; Sauter, J, 2011)
"The use of intrathecal neostigmine as an analgesic drug in perianal surgery is unsatisfactory because of prolonged motor blockade and nausea."5.10Analgesic effects of intrathecal neostigmine in perianal surgery. ( Erman, M; Karsli, B; Yegin, A; Yilmaz, M, 2003)
"In the sub-Tenon's bupivacaine group, there was a significant reduction in the perioperative opioid use and a reduction in the frequency of bradycardia and hypertensive episodes, defined as a rise > 25% of baseline for a duration of > 3 min."5.10Sub-Tenon's block reduces both intraoperative and postoperative analgesia requirement in vitreo-retinal surgery under general anaesthesia. ( Farmery, AD; Rahman, R; Rosen, P; Shlugman, D, 2003)
" The study's objectives were threefold: (i) evaluate the myocardial toxicity of levobupivacaine when administered intravenously; (ii) investigate levobupivacaine toxicity on cardiomyocytes mitochondrial functions and cellular structure; (iii) assess the protective effects of a lipid emulsion in the presence or absence of myocardial ischemia."3.81Electrophysiological, haemodynamic, and mitochondrial alterations induced by levobupivacaine during myocardial ischemia in a pig model: protection by lipid emulsions? ( Bui-Xuan, B; Chevalier, P; Descotes, J; Mamou, Z; Romestaing, C; Timour, Q, 2015)
"The purpose of this study was to determine, by continual reassessment, the 90% effective dose (ED90) of phenylephrine for hypotension after combined spinal-epidural anesthesia."3.81Determination of the 90% effective dose (ED90) of phenylephrine for hypotension during elective cesarean delivery using a continual reassessment method. ( Diao, M; Huang, Y; Li, H; Lin, X; Liu, H; Ma, Y; Zhou, J, 2015)
"Severe hypocapnic alkalosis prolonged the recovery time from 273 +/- 122 sec, at the 1 microg x mL(-1) bupivacaine concentration with normal pH washout, to 1203 +/- 540 sec, in the bupivacaine with hypocapnic alkalosis washout (p = 0."3.74Hypocapnia prolongs bradycardia induced by bupivacaine or levobupivacaine in isolated rat hearts. ( Mochizuki, T; Sato, S, 2008)
"Usage of high dose of heavy bupivacaine and level of blockage higher than T5 were two modifiable risk factors associated with hypotension during spinal anesthesia."3.74Prospective study of hypotension and bradycardia during spinal anesthesia with bupivacaine: incidence and risk factors, part two. ( Chinachoti, T; Tritrakarn, T, 2007)
" Resuscitation was performed using open-chest heart massage, bretylium for ventricular tachycardia, and epinephrine with atropine for electromechanical dissociation and bradycardia."3.67Successful cardiovascular resuscitation after massive intravenous bupivacaine overdosage in anesthetized dogs. ( Kasten, GW; Martin, ST, 1985)
"Bradycardia and hypotension were the first major signs of toxicity from a 250 mg bupivacaine axillary brachial plexus block experienced by a patient with chronic renal failure, who had an anion gap acidosis and hyperkalaemia."3.66Bupivacaine cardiotoxicity in a patient with renal failure. ( Aldrete, JA; Gould, DB, 1983)
"This is the first dose-finding study specifically designed to estimate the ED95 of intrathecal bupivacaine combined with a fixed amount of fentanyl for analgesia in active labor."2.73Determination of the ED95 for intrathecal plain bupivacaine combined with fentanyl in active labor. ( Carvalho, JC; Goldszmidt, E; Parkes, RK; Whitty, R, 2007)
"Fetal bradycardia is multifactorial, and predicting it poses a significant challenge to clinicians."1.91Fetal heart rate changes and labor neuraxial analgesia: a machine learning approach. ( Avella-Molano, B; Polania-Gutierrez, JJ; Riveros-Perez, E, 2023)
"His bradycardia was refractory to atropine."1.48Profound Prolonged Bradycardia and Hypotension after Interscalene Brachial Plexus Block with Bupivacaine. ( Lee, D; Nelson, M; Reda, L; Reens, A, 2018)
"The case of cardiopulmonary arrest we report is rare in the literature."1.31[Cardiorespiratory arrest: a rare complication of subdural block]. ( Bermejo, S; Escolano, F; Montes, A; Sánchez, JC; Silva Costa-Gomes, T, 2002)
"Sensitivity and specificity were 50% and 97%, respectively."1.29Factors associated with hypotension and bradycardia after epidural blockade. ( Curatolo, M; Orlando, A; Scaramozzino, P; Venuti, FS; Zbinden, AM, 1996)
"Bupivacaine was demonstrated in the systemic venous circulation in every case prior to surgery, whilst the tourniquet remained deflated."1.27Intravenous regional anaesthesia for foot surgery. ( Davies, JA; Walford, AJ, 1986)
"In all animals in whom ventricular arrhythmias were associated with lidocaine, the arrhythmias spontaneously reverted to normal sinus rhythm."1.27Cardiovascular toxicity of local anesthetics: an alternative hypothesis. ( Behbehani, MM; Coyle, DE; Denson, DD; Thomas, RD, 1986)

Research

Studies (72)

TimeframeStudies, this research(%)All Research%
pre-199020 (27.78)18.7374
1990's14 (19.44)18.2507
2000's18 (25.00)29.6817
2010's19 (26.39)24.3611
2020's1 (1.39)2.80

Authors

AuthorsStudies
Riveros-Perez, E1
Polania-Gutierrez, JJ1
Avella-Molano, B1
Nelson, M2
Reens, A1
Reda, L1
Lee, D1
Slagt, C1
Ketelaars, R1
Swenne, M1
Jan van Geffen, G1
Clivatti, J1
Siddiqui, N1
Goel, A1
Shaw, M1
Crisan, I1
Carvalho, JC2
Vadi, MG1
Patel, N1
Stiegler, MP1
Khaw, KS1
Lee, SW1
Ngan Kee, WD1
Law, LW1
Lau, TK1
Ng, FF1
Leung, TY1
Mamou, Z1
Descotes, J1
Chevalier, P1
Bui-Xuan, B1
Romestaing, C1
Timour, Q1
Liu, H1
Huang, Y1
Diao, M1
Li, H1
Ma, Y1
Lin, X1
Zhou, J1
Tomak, Y1
Erdivanli, B1
Sen, A1
Bostan, H1
Budak, ET1
Pergel, A1
Ferré, F1
Marty, P1
Bruneteau, L1
Merlet, V1
Bataille, B1
Ferrier, A1
Gris, C1
Kurrek, M1
Fourcade, O1
Minville, V1
Sommet, A1
Bhosale, G1
Shah, V1
Mochizuki, T1
Sato, S1
Burns, SM1
Malvasi, A1
Tinelli, A1
Stark, M1
Pontrelli, G1
Brizzi, A1
Wetzl, RG1
Benhamou, D1
Esmaoglu, A1
Yegenoglu, F1
Akin, A1
Turk, CY1
Chamchad, D1
Horrow, JC1
Nakhamchik, L1
Sauter, J1
Roberts, N1
Aronzon, B1
Gerson, A1
Medved, M1
Shih, YH1
Chen, CH1
Wang, YM1
Liu, K1
Dudley, MH1
Fleming, SW1
Garg, U1
Edwards, JM1
Rafaniello, C1
Ianniello, B1
De Vizia, M1
Mercogliano, A1
Lettieri, B1
Rinaldi, B1
Rossi, F1
Capuano, A1
Jain, K1
Makkar, JK1
Yadanappudi, S1
Anbarasan, I1
Gander, S1
Sarić, JP1
Mikulandra, S1
Gustin, D1
Matasić, H1
Tomulić, K1
Dokoza, KP1
Jaime, F1
Degani, J1
Lam, N1
Allen, G1
Yegin, A1
Yilmaz, M1
Karsli, B1
Erman, M1
Farmery, AD1
Shlugman, D1
Rahman, R1
Rosen, P1
Kuczkowski, KM1
Pippa, P1
Cuomo, P1
Panchetti, A1
Scarchini, M1
Poggi, G1
D'Arienzo, M1
Adekanye, O1
Srinivas, K1
Collis, RE1
Chinachoti, T1
Tritrakarn, T1
Kachko, L1
Simhi, E1
Tzeitlin, E1
Efrat, R1
Tarabikin, E1
Peled, E1
Metzner, I1
Katz, J1
Whitty, R1
Goldszmidt, E1
Parkes, RK1
Jagadeesan, J1
Kannan, R1
Dujon, D1
Errando, CL1
Murcia, M1
Gimeno, A1
Herrera, R1
Iff, I1
Moens, Y1
Gould, DB1
Aldrete, JA1
Vincenti, E1
Tambuscio, B1
Mega, M1
Fais, GF1
Polato, D1
Pitton, MA1
Di Lenardo, L1
Ambrosini, A1
Räsänen, J1
Jouppila, P1
Park, GR1
Slapak, G1
Freid, EB1
Bailey, AG1
Valley, RD1
Bruelle, P1
LeFrant, JY1
de La Coussaye, JE2
Peray, PA2
Desch, G1
Sassine, A2
Eledjam, JJ2
Nielsen, PE1
Erickson, JR1
Abouleish, EI1
Perriatt, S1
Sheppard, C1
Curatolo, M1
Scaramozzino, P1
Venuti, FS1
Orlando, A1
Zbinden, AM1
D'Angelo, R1
Eisenach, JC1
Kimura, I1
Takada, M1
Nojima, H1
Joos, S1
Van Steenberge, A1
Kunst, G1
Linderkamp, O1
Holle, R1
Motsch, J1
Martin, E1
Ponhold, H1
Vicenzi, MN1
Wong, CA1
Scavone, BM1
Loffredi, M1
Wang, WY1
Peaceman, AM1
Ganchiff, JN1
William, JM1
Stoddart, PA1
Williams, SA1
Wolf, AR2
Ehikhametalor, KO1
Silva Costa-Gomes, T1
Montes, A1
Sánchez, JC1
Bermejo, S1
Escolano, F1
López-Soriano, F1
Lajarín, B1
Rivas, F1
Verdú, JM1
López-Robles, J1
Engberg, G1
Wiklund, L1
Stratmann, D1
Götte, A1
Meyer-Hamme, K1
Watermann, WF1
Nolte, H1
Rüther, K1
Stockhausen, H2
Abouleish, E1
Matta, BF1
Magee, P1
Bassoul, BP1
Albat, B1
Gagnol, JP1
Walker, SM1
Kao, YJ1
Zavisca, F1
Enty, D1
Melloni, C1
Begliomini, B1
Liverani, L1
Gaspari, A1
Davies, JA1
Walford, AJ1
Thomas, RD1
Behbehani, MM1
Coyle, DE1
Denson, DD1
Kasten, GW1
Martin, ST1
Sehhati, G1
Frey, R1
Mildner, R1
Diesbecq, W1
Rolly, G1
Thiery, M1
Ramaioli, F1
Pagani, I1
Boileau, PA1
Turcot, MJ1
Thalme, B1
Belfrage, P1
Raabe, N1
Hickl, EJ1
Gennser, G1

Clinical Trials (14)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Effect of Sevoflurane on the Success of External Cephalic Version for Breech Presentation[NCT04346823]Phase 440 participants (Anticipated)Interventional2020-05-25Not yet recruiting
Spinal Anesthesia for External Cephalic Version in Nulliparous Women, A Controlled Randomized Study[NCT03797833]200 participants (Anticipated)Interventional2019-01-07Suspended (stopped due to Slow inclusion rate. Central contact person quit for another job.)
Comparison Between Quadratus Lumborum Block and Epidural on Stress Response and Perioperative Cellular Immunological Function of Laparoscopic Nephrectomy Kidney Donor[NCT03520205]62 participants (Actual)Interventional2018-05-01Completed
Analgesic Effect of Three-point Transversus Abdominis Plane Block Compared With Continuous Epidural Infusion for Post-laparoscopic Nephrectomy[NCT03154463]50 participants (Actual)Interventional2017-09-01Completed
Is the Application of Scopolamine Patch With or Without Intra-operative Acupressure Point P6 Stimulation More Effective Than Intra-operative Acupressure Point P6 Stimulation Alone?[NCT02960113]Phase 4240 participants (Actual)Interventional2016-05-31Completed
The Effect of Dexamedetomidine for Interscalene Brachial Plexus Block on Plasma Cortisol and IL-6 After Rotator Cuff Repair: a Prospective Randomized Study[NCT02766556]50 participants (Actual)Interventional2014-08-31Completed
Double Blinded Randomized Controlled Study Evaluating the Analgesic Duration of Dexmedetomidine Compared to Dexamethasone as Adjuncts to Single Shot Interscalene Block in Patients Undergoing Ambulatory Shoulder Surgery[NCT02653144]Phase 4105 participants (Actual)Interventional2016-03-31Completed
Addition of Dexmedetomidine to Ropivacaine-induced Supraclavicular Plexus Block, a Randomized Controlled Study[NCT02630290]Phase 460 participants (Actual)Interventional2015-12-31Completed
Effect of Glycopyrrolate on Vasopressors Requirement for Non-elective Caesarean Section Under Spinal Anaesthesia[NCT04401345]Phase 4258 participants (Actual)Interventional2020-06-01Completed
Hypotension in Spinal Anesthesia for Total Knee Joint Arthroplasty: a Comparison of Taylor's Approach With Paramedian Lumbar Approach[NCT02302378]30 participants (Actual)Interventional2015-01-31Completed
Can Vena Cava Ultrasound Guided Volume Repletion Prevent Spinal Induced Significant Hypotension in Elective Surgical Patients? A Randomized, Case Control, Prospective Trial.[NCT02271477]160 participants (Actual)Interventional2014-05-31Completed
Inferior Venacava Ultrasound to Guide Fluid Management for Prevention of Hypotension After Spinal Anesthesia.[NCT04736498]92 participants (Actual)Interventional2018-12-12Completed
Pulse Pressure-guided IV Fluid Preload to Prevent Post-epidural Fetal Heart Rate (FHR) Changes: a Randomized Controlled Trial[NCT02565485]276 participants (Actual)Interventional2015-09-01Completed
Plasmatic Catecholamines After Neuraxial Labor Analgesia: a Randomized Controlled Trial Comparing Epidural Versus Combined Spinal-epidural[NCT02666794]50 participants (Actual)Interventional2017-07-12Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Level of Nausea After Eversion of the Uterus

Patients offer their subjective assessments of the level of nausea on a scale of 0-10 (0 = no nausea, 10 = worst nausea ever experienced) after eversion of the uterus. The investigators will analyze if there is a statistically significant difference between the number of patients that experience nausea in each group at this point. Patients that report nausea (1 or more on our scale) will be recorded as that they have experienced nausea. (NCT02960113)
Timeframe: After eversion of the uterus until replacement of the uterus

Interventionunits on a scale (Mean)
Scopolamine Patch1.28
Acupressure Point P61.09
Scopolamine Patch + Acupressure Point P61.40

Level of Nausea After Replacement of the Uterus

Patients offer their subjective assessments of the level of nausea on a scale of 0-10 (0 = no nausea, 10 = worst nausea ever experienced) after replacement of the uterus. The investigators will analyze if there is a statistically significant difference between the number of patients that experience nausea in each group at this point. Patients that report nausea (1 or more on our scale) will be recorded as that they have experienced nausea. (NCT02960113)
Timeframe: After replacement of the uterus and to the next 15 minutes

Interventionunits on a scale (Mean)
Scopolamine Patch2.19
Acupressure Point P62.19
Scopolamine Patch + Acupressure Point P62.51

Level of Nausea After the Administration of the Regional Anesthesia Medications

Patients offer their subjective assessments of the level of nausea on a scale of 0-10 (0 = no nausea, 10 = worst nausea ever experienced) after the administration of the regional anesthesia medications. The investigators will analyze if there is a statistically significant difference between the number of patients that experience nausea in each group at this point. Patients that report nausea (1 or more on our scale) will be recorded as that they have experienced nausea. (NCT02960113)
Timeframe: From administration of anaesthesia until eversion of uterus

Interventionunits on a scale (Mean)
Scopolamine Patch2.71
Acupressure Point P62.57
Scopolamine Patch + Acupressure Point P62.84

Level of Nausea Upon Arrival to the Post-operative Recovery Room

Patients offer their subjective assessments of the level of nausea on a scale of 0-10 (0 = no nausea, 10 = worst nausea ever experienced) upon arrival to the post-operative recovery room. The investigators will analyze if there is a statistically significant difference between the number of patients that experience nausea in each group at this point. Patients that report nausea (1 or more on our scale) will be recorded as that they have experienced nausea. (NCT02960113)
Timeframe: 15 minutes after replacement of the uterus to arrival at post-anaesthesia care unit

Interventionunits on a scale (Mean)
Scopolamine Patch0.18
Acupressure Point P60.25
Scopolamine Patch + Acupressure Point P60.23

Number of Patients With Nausea

The investigators will analyze if there is a statistically significant difference between the number of patients that experience nausea at any point during the surgical procedure in each group. (NCT02960113)
Timeframe: Throughout the entire surgical procedure

InterventionParticipants (Count of Participants)
Scopolamine Patch40
Acupressure Point P639
Scopolamine Patch + Acupressure Point P646

Number of Patients With Vomiting

The investigators will perform objective assessments of whether or not the patients have vomited during the procedure. The investigators will then analyze if there is a statistically significant difference between the number of patients that vomit in each group. (NCT02960113)
Timeframe: Throughout the surgical procedure

InterventionParticipants (Count of Participants)
Scopolamine Patch24
Acupressure Point P625
Scopolamine Patch + Acupressure Point P631

Number of Patients With Vomiting After Eversion of the Uterus

Objective assessments of whether or not the patients have vomited at this point in the surgical procedure will be done. The investigators will analyze if there is a statistically significant difference between the number of patients that vomit in each group. (NCT02960113)
Timeframe: After eversion of to replacement of the uterus

InterventionParticipants (Count of Participants)
Scopolamine Patch8
Acupressure Point P66
Scopolamine Patch + Acupressure Point P69

Number of Patients With Vomiting After Replacement of the Uterus

Objective assessments of whether or not the patients have vomited at this point in the surgical procedure will be done. The investigators will analyze if there is a statistically significant difference between the number of patients that vomit in each group. (NCT02960113)
Timeframe: After replacement of the uterus and for next 15 minutes

InterventionParticipants (Count of Participants)
Scopolamine Patch10
Acupressure Point P615
Scopolamine Patch + Acupressure Point P612

Number of Patients With Vomiting After the Administration of the Regional Anesthesia Medications

Objective assessments of whether or not the patients have vomited at this point in the surgical procedure will be done. The investigators will analyze if there is a statistically significant difference between the number of patients that vomit in each group. (NCT02960113)
Timeframe: After the administration of the regional anesthesia medications until eversion of the uterus

InterventionParticipants (Count of Participants)
Scopolamine Patch20
Acupressure Point P615
Scopolamine Patch + Acupressure Point P620

Number of Patients With Vomiting Upon Arrival to the Post-operative Recovery Room

Objective assessments of whether or not the patients have vomited at this point in the surgical procedure will be done. The investigators will analyze if there is a statistically significant difference between the number of patients that vomit in each group. (NCT02960113)
Timeframe: From 15 minutes after replacement of the uterus until arrival at the post-anaesthesia care unit

InterventionParticipants (Count of Participants)
Scopolamine Patch1
Acupressure Point P61
Scopolamine Patch + Acupressure Point P64

Satisfaction With Intraoperative Antiemetic Treatment

Patients are asked their nausea and vomiting treatment satisfaction (0 = Not Satisfied, 10 = Extremely Satisfied). Patients are also asked their overall satisfaction with the procedure (0 = Not Satisfied, 10 = Extremely Satisfied). (NCT02960113)
Timeframe: Throughout the surgical procedure

Interventionunits on a scale (Mean)
Scopolamine Patch9.29
Acupressure Point P68.96
Scopolamine Patch + Acupressure Point P69.59

Opioid Requirements (Morphine Equivalents)

How much opioid did patient ask for within 24 hours post op (NCT02653144)
Timeframe: 24 hours

Interventionmorphine milligram equivalent (Mean)
Dexmedetomidine and Ropivacaine Group15
Dexamethasone and Ropivacaine Group15
Ropivacaine Only Group22.5

Opioid Requirements (Morphine Equivalents)

How much opioid did patient ask for within 48 hours post op (NCT02653144)
Timeframe: 48 hours

Interventionmorphine milligram equivalent (Mean)
Dexmedetomidine and Ropivacaine Group52.5
Dexamethasone and Ropivacaine Group30
Ropivacaine Only Group40

Return of Motor and Sensory Function

Between 24 to 48 hours after surgery, questionnaire will be used to determine if motor and sensory function have returned. (NCT02653144)
Timeframe: 24-48 hours after surgery

Interventionminutes (Median)
Dexmedetomidine and Ropivacaine Group1280
Dexamethasone and Ropivacaine Group1130
Ropivacaine Only Group900

Time to Discharge From PACU to First Opioid Consumption

How long after surgery does patient take to ask for opioid to manage pain (NCT02653144)
Timeframe: 24-48 hours after surgery

Interventionminutes (Mean)
Dexmedetomidine and Ropivacaine Group1280
Dexamethasone and Ropivacaine Group1130
Ropivacaine Only Group900

Percentage of Participants Administered Vasoactive Drug

"Total amount of vasoactive drug administered for each group; for vasoactive drug we intended the use both of atropine than vascular amine" (NCT02271477)
Timeframe: 30 minutes after spinal anesthesia

Interventionpercentage of participants (Number)
Wild-Type13.51
Echocardiography6.49

Rate of Arterial Hypotension

To compare rates of arterial hypotension (previously define by international standard) after spinal anesthesia in patients who have undergone volemic optimization according to Trans-thoracic Echocardiography with patients who have been treated according to the current standard on the intention to treat population. (NCT02271477)
Timeframe: 30 minute after spinal anesthesia

Interventionpercentage of participants (Number)
Wild-Type42.5
Echocardiography27.5

Time of Procedures

Time employed to execute all procedure from the start of the study till 30 minutes after the end of the procedure (NCT02271477)
Timeframe: From time 0 to 30 minutes after spinal anesthesia

Interventionminutes (Mean)
Wild-Type22
Echocardiography24

Total Amount of IV Fluid at the End of the Procedure

To assess if there is a difference between all treatments in the total quantity of fluids amount (NCT02271477)
Timeframe: 30 minutes after spinal anesthesia

Interventionmilliliters (mL) (Median)
Wild-Type350
Echocardiography665

Adverse Events (Pulmonary Edema)

Pulmonary edema occurring after preload bolus through delivery was considered an adverse event. (NCT02565485)
Timeframe: Duration of intrapartum course

InterventionParticipants (Count of Participants)
Standard IV Preload0
Volume Replacement IV Preload0

Incidence of New-onset Category II or III Fetal Heart Rate Tracings

Each fetal heart rate tracing was evaluated in 15 min increments from the completion of epidural placement and initial dose administration. ACOG Category I, II, and III was assigned to each 15 min increment. (NCT02565485)
Timeframe: First 60 minutes following epidural placement

InterventionParticipants (Count of Participants)
Standard IV Preload72
Volume Replacement IV Preload52

Interventions to Correct Maternal Hypotension or Fetal Heart Rate Abnormalities (Position Change, Supplemental Oxygen, Vasopressor Support, Emergent Operative Delivery)

(NCT02565485)
Timeframe: First 60 minutes following epidural placement

InterventionParticipants (Count of Participants)
Standard IV Preload61
Volume Replacement IV Preload25

New Onset Hypotension (>20% Decrease in Systolic and/or Diastolic Blood Pressure)

(NCT02565485)
Timeframe: First 60 minutes following epidural placement

InterventionParticipants (Count of Participants)
Standard IV Preload48
Volume Replacement IV Preload14

Trials

19 trials available for bupivacaine and Bradyarrhythmia

ArticleYear
Randomized trial of anaesthetic interventions in external cephalic version for breech presentation.
    British journal of anaesthesia, 2015, Volume: 114, Issue:6

    Topics: Adult; Anesthesia, Obstetrical; Anesthesia, Spinal; Anesthetics, Intravenous; Anesthetics, Local; Br

2015
Randomized trial of anaesthetic interventions in external cephalic version for breech presentation.
    British journal of anaesthesia, 2015, Volume: 114, Issue:6

    Topics: Adult; Anesthesia, Obstetrical; Anesthesia, Spinal; Anesthetics, Intravenous; Anesthetics, Local; Br

2015
Randomized trial of anaesthetic interventions in external cephalic version for breech presentation.
    British journal of anaesthesia, 2015, Volume: 114, Issue:6

    Topics: Adult; Anesthesia, Obstetrical; Anesthesia, Spinal; Anesthetics, Intravenous; Anesthetics, Local; Br

2015
Randomized trial of anaesthetic interventions in external cephalic version for breech presentation.
    British journal of anaesthesia, 2015, Volume: 114, Issue:6

    Topics: Adult; Anesthesia, Obstetrical; Anesthesia, Spinal; Anesthetics, Intravenous; Anesthetics, Local; Br

2015
Effect of cooled hyperbaric bupivacaine on unilateral spinal anesthesia success rate and hemodynamic complications in inguinal hernia surgery.
    Journal of anesthesia, 2016, Volume: 30, Issue:1

    Topics: Adolescent; Adult; Anesthesia, Spinal; Anesthetics, Local; Bradycardia; Bupivacaine; Elective Surgic

2016
Prophylactic phenylephrine infusion for the prevention of hypotension after spinal anesthesia in the elderly: a randomized controlled clinical trial.
    Journal of clinical anesthesia, 2016, Volume: 35

    Topics: Adjuvants, Anesthesia; Adrenergic alpha-1 Receptor Agonists; Aged; Aged, 80 and over; Anesthesia, Sp

2016
Dexmedetomidine added to levobupivacaine prolongs axillary brachial plexus block.
    Anesthesia and analgesia, 2010, Volume: 111, Issue:6

    Topics: Adult; Analgesia; Analgesics, Non-Narcotic; Anesthetics, Local; Blood Pressure; Brachial Plexus; Bra

2010
Dexmedetomidine added to levobupivacaine prolongs axillary brachial plexus block.
    Anesthesia and analgesia, 2010, Volume: 111, Issue:6

    Topics: Adult; Analgesia; Analgesics, Non-Narcotic; Anesthetics, Local; Blood Pressure; Brachial Plexus; Bra

2010
Dexmedetomidine added to levobupivacaine prolongs axillary brachial plexus block.
    Anesthesia and analgesia, 2010, Volume: 111, Issue:6

    Topics: Adult; Analgesia; Analgesics, Non-Narcotic; Anesthetics, Local; Blood Pressure; Brachial Plexus; Bra

2010
Dexmedetomidine added to levobupivacaine prolongs axillary brachial plexus block.
    Anesthesia and analgesia, 2010, Volume: 111, Issue:6

    Topics: Adult; Analgesia; Analgesics, Non-Narcotic; Anesthetics, Local; Blood Pressure; Brachial Plexus; Bra

2010
Dexmedetomidine added to levobupivacaine prolongs axillary brachial plexus block.
    Anesthesia and analgesia, 2010, Volume: 111, Issue:6

    Topics: Adult; Analgesia; Analgesics, Non-Narcotic; Anesthetics, Local; Blood Pressure; Brachial Plexus; Bra

2010
Dexmedetomidine added to levobupivacaine prolongs axillary brachial plexus block.
    Anesthesia and analgesia, 2010, Volume: 111, Issue:6

    Topics: Adult; Analgesia; Analgesics, Non-Narcotic; Anesthetics, Local; Blood Pressure; Brachial Plexus; Bra

2010
Dexmedetomidine added to levobupivacaine prolongs axillary brachial plexus block.
    Anesthesia and analgesia, 2010, Volume: 111, Issue:6

    Topics: Adult; Analgesia; Analgesics, Non-Narcotic; Anesthetics, Local; Blood Pressure; Brachial Plexus; Bra

2010
Dexmedetomidine added to levobupivacaine prolongs axillary brachial plexus block.
    Anesthesia and analgesia, 2010, Volume: 111, Issue:6

    Topics: Adult; Analgesia; Analgesics, Non-Narcotic; Anesthetics, Local; Blood Pressure; Brachial Plexus; Bra

2010
Dexmedetomidine added to levobupivacaine prolongs axillary brachial plexus block.
    Anesthesia and analgesia, 2010, Volume: 111, Issue:6

    Topics: Adult; Analgesia; Analgesics, Non-Narcotic; Anesthetics, Local; Blood Pressure; Brachial Plexus; Bra

2010
Prophylactic glycopyrrolate prevents bradycardia after spinal anesthesia for Cesarean section: a randomized, double-blinded, placebo-controlled prospective trial with heart rate variability correlation.
    Journal of clinical anesthesia, 2011, Volume: 23, Issue:5

    Topics: Adjuvants, Anesthesia; Adult; Anesthesia, Spinal; Anesthetics, Local; Bradycardia; Bupivacaine; Cesa

2011
Two doses of spinal bupivacaine for caesarean delivery in severe preeclampsia: a pilot study.
    International journal of obstetric anesthesia, 2012, Volume: 21, Issue:2

    Topics: Adrenergic Agents; Adrenergic alpha-1 Receptor Agonists; Adult; Anesthesia, Spinal; Anesthetics, Int

2012
Spinal anesthesia at the L2-3 and L3-4 levels: comparison of analgesia and hemodynamic response.
    Collegium antropologicum, 2012, Volume: 36, Issue:1

    Topics: Adult; Aged; Anesthesia, Spinal; Anesthetics, Local; Bradycardia; Bupivacaine; Hemodynamics; Hernia,

2012
Analgesic effects of intrathecal neostigmine in perianal surgery.
    European journal of anaesthesiology, 2003, Volume: 20, Issue:5

    Topics: Anal Canal; Anesthesia, Local; Anesthetics, Combined; Anesthetics, Local; Bradycardia; Bupivacaine;

2003
Sub-Tenon's block reduces both intraoperative and postoperative analgesia requirement in vitreo-retinal surgery under general anaesthesia.
    European journal of anaesthesiology, 2003, Volume: 20, Issue:12

    Topics: Acetaminophen; Aged; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthesia, General;

2003
High volume and low concentration of anaesthetic solution in the perivascular interscalene sheath determines quality of block and incidence of complications.
    European journal of anaesthesiology, 2006, Volume: 23, Issue:10

    Topics: Adrenergic Agonists; Adult; Aged; Anesthetics, Local; Brachial Plexus; Bradycardia; Bupivacaine; Epi

2006
Determination of the ED95 for intrathecal plain bupivacaine combined with fentanyl in active labor.
    International journal of obstetric anesthesia, 2007, Volume: 16, Issue:4

    Topics: Adult; Anesthesia, Epidural; Anesthesia, Obstetrical; Anesthesia, Spinal; Anesthetics, Combined; Ane

2007
Fetal heart rate changes after intrathecal sufentanil or epidural bupivacaine for labor analgesia: incidence and clinical significance.
    Anesthesia and analgesia, 1996, Volume: 83, Issue:4

    Topics: Adult; Analgesia, Epidural; Analgesia, Obstetrical; Analgesics, Opioid; Anesthetics, Local; Bradycar

1996
Fetal heart rate changes after intrathecal sufentanil or epidural bupivacaine for labor analgesia: incidence and clinical significance.
    Anesthesia and analgesia, 1996, Volume: 83, Issue:4

    Topics: Adult; Analgesia, Epidural; Analgesia, Obstetrical; Analgesics, Opioid; Anesthetics, Local; Bradycar

1996
Fetal heart rate changes after intrathecal sufentanil or epidural bupivacaine for labor analgesia: incidence and clinical significance.
    Anesthesia and analgesia, 1996, Volume: 83, Issue:4

    Topics: Adult; Analgesia, Epidural; Analgesia, Obstetrical; Analgesics, Opioid; Anesthetics, Local; Bradycar

1996
Fetal heart rate changes after intrathecal sufentanil or epidural bupivacaine for labor analgesia: incidence and clinical significance.
    Anesthesia and analgesia, 1996, Volume: 83, Issue:4

    Topics: Adult; Analgesia, Epidural; Analgesia, Obstetrical; Analgesics, Opioid; Anesthetics, Local; Bradycar

1996
The proportion of high risk preterm infants with postoperative apnea and bradycardia is the same after general and spinal anesthesia.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1999, Volume: 46, Issue:1

    Topics: Anesthesia, General; Anesthesia, Spinal; Anesthetics, Inhalation; Anesthetics, Local; Apnea; Bradyca

1999
Incidence of bradycardia during recovery from spinal anaesthesia: influence of patient position.
    British journal of anaesthesia, 1998, Volume: 81, Issue:5

    Topics: Adolescent; Adult; Anesthesia Recovery Period; Anesthesia, Spinal; Anesthetics, Local; Bradycardia;

1998
The dose-response of intrathecal sufentanil added to bupivacaine for labor analgesia.
    Anesthesiology, 2000, Volume: 92, Issue:6

    Topics: Adult; Analgesia, Obstetrical; Analgesics, Opioid; Anesthetics, Local; Bradycardia; Bupivacaine; Dos

2000
Post-operative recovery after inguinal herniotomy in ex-premature infants: comparison between sevoflurane and spinal anaesthesia.
    British journal of anaesthesia, 2001, Volume: 86, Issue:3

    Topics: Anesthesia, Spinal; Anesthetics, Inhalation; Anesthetics, Local; Apnea; Bradycardia; Bupivacaine; He

2001
Intrathecal pethidine as sole anaesthetic agent for operative procedures of the lower limb, inguinal area and perineum.
    The West Indian medical journal, 2001, Volume: 50, Issue:4

    Topics: Adult; Aged; Ambulatory Surgical Procedures; Analgesics, Opioid; Anesthesia, Spinal; Anesthetics, Lo

2001
[Hyperbaric subarachnoid ropivacaine in ambulatory surgery: comparative study with hyperbaric bupivacaine].
    Revista espanola de anestesiologia y reanimacion, 2002, Volume: 49, Issue:2

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Ambulatory Surgical Procedures; Amides; Anesthesia Recov

2002
[Our experience in the use of hyperbaric 1 percent bupivacaine in 321 cases of spinal anesthesia in orthopedic and traumatologic surgery].
    Minerva anestesiologica, 1972, Volume: 38, Issue:1

    Topics: Adult; Aged; Anesthesia, Spinal; Blood Pressure; Bradycardia; Bupivacaine; Clinical Trials as Topic;

1972

Other Studies

53 other studies available for bupivacaine and Bradyarrhythmia

ArticleYear
Fetal heart rate changes and labor neuraxial analgesia: a machine learning approach.
    BMC pregnancy and childbirth, 2023, May-22, Volume: 23, Issue:1

    Topics: Analgesia, Epidural; Analgesia, Obstetrical; Bradycardia; Bupivacaine; Female; Heart Rate, Fetal; Hu

2023
Profound Prolonged Bradycardia and Hypotension after Interscalene Brachial Plexus Block with Bupivacaine.
    The Journal of emergency medicine, 2018, Volume: 54, Issue:3

    Topics: Aged; Anesthetics, Local; Atropine; Brachial Plexus Block; Bradycardia; Bupivacaine; Emergency Servi

2018
Local Anesthetic Systemic Toxicity (LAST), Needs Treatment.
    The Journal of emergency medicine, 2019, Volume: 56, Issue:1

    Topics: Anesthetics, Local; Brachial Plexus Block; Bradycardia; Bupivacaine; Humans; Hypotension

2019
Quality of labour neuraxial analgesia and maternal satisfaction at a tertiary care teaching hospital: a prospective observational study.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2013, Volume: 60, Issue:8

    Topics: Adjuvants, Anesthesia; Adult; Analgesia, Epidural; Analgesia, Obstetrical; Analgesia, Patient-Contro

2013
Local anesthetic systemic toxicity after combined psoas compartment-sciatic nerve block: analysis of decision factors and diagnostic delay.
    Anesthesiology, 2014, Volume: 120, Issue:4

    Topics: Aged, 80 and over; Anesthetics, Local; Bradycardia; Bupivacaine; Delayed Diagnosis; Epilepsy, Tonic-

2014
Electrophysiological, haemodynamic, and mitochondrial alterations induced by levobupivacaine during myocardial ischemia in a pig model: protection by lipid emulsions?
    Fundamental & clinical pharmacology, 2015, Volume: 29, Issue:5

    Topics: Action Potentials; Anesthetics, Local; Animals; Arterial Pressure; Bradycardia; Bupivacaine; Calcium

2015
Determination of the 90% effective dose (ED90) of phenylephrine for hypotension during elective cesarean delivery using a continual reassessment method.
    European journal of obstetrics, gynecology, and reproductive biology, 2015, Volume: 194

    Topics: Adult; Anesthesia, Epidural; Anesthesia, Obstetrical; Anesthesia, Spinal; Anesthetics, Local; Apgar

2015
Combined spinal-epidural anesthesia for renal transplantation.
    Transplantation proceedings, 2008, Volume: 40, Issue:4

    Topics: Adult; Analgesics; Anesthesia, Epidural; Anesthesia, Spinal; Anesthetics, Local; Blood Pressure; Bra

2008
Combined spinal-epidural anesthesia for renal transplantation.
    Transplantation proceedings, 2008, Volume: 40, Issue:4

    Topics: Adult; Analgesics; Anesthesia, Epidural; Anesthesia, Spinal; Anesthetics, Local; Blood Pressure; Bra

2008
Combined spinal-epidural anesthesia for renal transplantation.
    Transplantation proceedings, 2008, Volume: 40, Issue:4

    Topics: Adult; Analgesics; Anesthesia, Epidural; Anesthesia, Spinal; Anesthetics, Local; Blood Pressure; Bra

2008
Combined spinal-epidural anesthesia for renal transplantation.
    Transplantation proceedings, 2008, Volume: 40, Issue:4

    Topics: Adult; Analgesics; Anesthesia, Epidural; Anesthesia, Spinal; Anesthetics, Local; Blood Pressure; Bra

2008
Hypocapnia prolongs bradycardia induced by bupivacaine or levobupivacaine in isolated rat hearts.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2008, Volume: 55, Issue:12

    Topics: Alkalosis; Anesthesia Recovery Period; Anesthetics, Local; Animals; Bradycardia; Bupivacaine; Heart

2008
Local anesthetic toxicity.
    Nursing, 2010, Volume: 40, Issue:2

    Topics: Aged; Anesthetics, Local; Bradycardia; Bupivacaine; Confusion; Emergencies; Humans; Hypotension; Mal

2010
Low-dose sequential combined spinal-epidural anaesthesia in elective Stark caesarean section: a preliminary cohort study.
    European review for medical and pharmacological sciences, 2010, Volume: 14, Issue:3

    Topics: Adult; Analgesics, Opioid; Anesthesia, Epidural; Anesthesia, Spinal; Anesthetics, Local; Bradycardia

2010
Successful reversal of bupivacaine and lidocaine-induced severe junctional bradycardia by lipid emulsion following infraclavicular brachial plexus block in a uremic patient.
    Acta anaesthesiologica Taiwanica : official journal of the Taiwan Society of Anesthesiologists, 2011, Volume: 49, Issue:2

    Topics: Aged; Anesthetics, Local; Brachial Plexus; Bradycardia; Bupivacaine; Fat Emulsions, Intravenous; Fem

2011
Fatality involving complications of bupivacaine toxicity and hypersensitivity reaction.
    Journal of forensic sciences, 2011, Volume: 56, Issue:5

    Topics: Adult; Anesthetics, Local; Atrial Septum; Bradycardia; Bupivacaine; Cardiomegaly; Drug Hypersensitiv

2011
Cardiorespiratory effects of change in posture after spinal anesthesia with hyperbaric bupivacaine.
    Minerva medica, 2011, Volume: 102, Issue:6

    Topics: Anesthesia Recovery Period; Anesthesia, Spinal; Anesthetics, Local; Bradycardia; Bupivacaine; Dyspne

2011
Placental abruption occurring soon after labor combined spinal-epidural analgesia.
    International journal of obstetric anesthesia, 2012, Volume: 21, Issue:4

    Topics: Abruptio Placentae; Adult; Analgesia, Epidural; Analgesia, Obstetrical; Anesthesia, Spinal; Anesthet

2012
Severe persistent fetal bradycardia following subarachnoid administration of fentanyl and bupivacaine for induction of a combined spinal-epidural analgesia for labor pain.
    Journal of clinical anesthesia, 2004, Volume: 16, Issue:1

    Topics: Adult; Analgesia, Epidural; Analgesia, Obstetrical; Analgesics, Opioid; Anesthesia, Spinal; Anesthet

2004
Bradyarrhythmias in pregnancy: a case report and review of management.
    International journal of obstetric anesthesia, 2007, Volume: 16, Issue:2

    Topics: Adult; Anesthesia, Obstetrical; Anesthetics, Intravenous; Anesthetics, Local; Blood Pressure; Bradyc

2007
Prospective study of hypotension and bradycardia during spinal anesthesia with bupivacaine: incidence and risk factors, part two.
    Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 2007, Volume: 90, Issue:3

    Topics: Adult; Aged; Anesthesia, Spinal; Anesthetics, Local; Bradycardia; Bupivacaine; Female; Humans; Hypot

2007
Prospective study of hypotension and bradycardia during spinal anesthesia with bupivacaine: incidence and risk factors, part two.
    Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 2007, Volume: 90, Issue:3

    Topics: Adult; Aged; Anesthesia, Spinal; Anesthetics, Local; Bradycardia; Bupivacaine; Female; Humans; Hypot

2007
Prospective study of hypotension and bradycardia during spinal anesthesia with bupivacaine: incidence and risk factors, part two.
    Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 2007, Volume: 90, Issue:3

    Topics: Adult; Aged; Anesthesia, Spinal; Anesthetics, Local; Bradycardia; Bupivacaine; Female; Humans; Hypot

2007
Prospective study of hypotension and bradycardia during spinal anesthesia with bupivacaine: incidence and risk factors, part two.
    Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 2007, Volume: 90, Issue:3

    Topics: Adult; Aged; Anesthesia, Spinal; Anesthetics, Local; Bradycardia; Bupivacaine; Female; Humans; Hypot

2007
Spinal anesthesia in neonates and infants - a single-center experience of 505 cases.
    Paediatric anaesthesia, 2007, Volume: 17, Issue:7

    Topics: Anesthesia, Spinal; Anesthetics, Local; Apnea; Body Weight; Bradycardia; Bupivacaine; Female; Gestat

2007
Ventricular standstill: a complication of intrapleural anesthesia using bupivacaine in a patient with free transverse rectus abdominus myocutaneous flap breast reconstruction.
    Annals of plastic surgery, 2007, Volume: 59, Issue:4

    Topics: Anesthesia, Local; Anesthetics, Local; Bradycardia; Breast Neoplasms; Bupivacaine; Carcinoma, Intrad

2007
[Anesthesia in a patient with Angelman syndrome].
    Revista espanola de anestesiologia y reanimacion, 2007, Volume: 54, Issue:9

    Topics: Adolescent; Androstanols; Anesthesia, Inhalation; Anesthesia, Intravenous; Angelman Syndrome; Bradyc

2007
Two cases of bradyarrhythmia and hypotension after extradural injections in dogs.
    Veterinary anaesthesia and analgesia, 2008, Volume: 35, Issue:3

    Topics: Analgesics; Animals; Bradycardia; Bupivacaine; Dog Diseases; Dogs; Female; Hypotension; Injections,

2008
Bupivacaine cardiotoxicity in a patient with renal failure.
    Acta anaesthesiologica Scandinavica, 1983, Volume: 27, Issue:1

    Topics: Acidosis; Brachial Plexus; Bradycardia; Bupivacaine; Heart; Humans; Hyperkalemia; Hypotension; Kidne

1983
Cardiotocographic modifications during continuous epidural anaesthesia in labour.
    Clinical and experimental obstetrics & gynecology, 1981, Volume: 8, Issue:3

    Topics: Adult; Anesthesia, Epidural; Anesthesia, Obstetrical; Bradycardia; Bupivacaine; Female; Fetal Diseas

1981
Does a paracervical block with bupivacaine change vascular resistance in uterine and umbilical arteries?
    Journal of perinatal medicine, 1994, Volume: 22, Issue:4

    Topics: Analgesia, Obstetrical; Blood Flow Velocity; Bradycardia; Bupivacaine; Cervix Uteri; Evaluation Stud

1994
Bupivacaine protects against vagal bradycardia during tracheal suction.
    Anaesthesia, 1993, Volume: 48, Issue:5

    Topics: Bradycardia; Bupivacaine; Female; Humans; Middle Aged; Suction; Trachea

1993
Electrocardiographic and hemodynamic changes associated with unintentional intravascular injection of bupivacaine with epinephrine in infants.
    Anesthesiology, 1993, Volume: 79, Issue:2

    Topics: Anesthesia, Caudal; Bradycardia; Bupivacaine; Electrocardiography; Epinephrine; Hemodynamics; Hernia

1993
Comparative electrophysiologic and hemodynamic effects of several amide local anesthetic drugs in anesthetized dogs.
    Anesthesia and analgesia, 1996, Volume: 82, Issue:3

    Topics: Amides; Anesthetics, Local; Animals; Aorta; Atrial Function; Atrioventricular Node; Blood Pressure;

1996
Factors associated with hypotension and bradycardia after epidural blockade.
    Anesthesia and analgesia, 1996, Volume: 83, Issue:5

    Topics: Adjuvants, Anesthesia; Adult; Aged; Analgesia, Epidural; Anesthesia, Epidural; Anesthetics, Local; B

1996
Severe maternal hypotension and fetal bradycardia after a combined spinal epidural anesthetic.
    Anesthesiology, 1997, Volume: 87, Issue:1

    Topics: Adult; Anesthesia, Epidural; Anesthesia, Obstetrical; Anesthetics, Combined; Bradycardia; Bupivacain

1997
Aconitine induces bradycardia through a transmission pathway including the anterior hypothalamus in conscious mice.
    Biological & pharmaceutical bulletin, 1997, Volume: 20, Issue:8

    Topics: Aconitine; Anesthetics, Local; Animals; Atropine; Blood Pressure; Bradycardia; Bupivacaine; Cerebral

1997
Does anesthesiology, like history, repeat itself?
    Anesthesiology, 1998, Volume: 89, Issue:2

    Topics: Adult; Anesthesia, Obstetrical; Anesthetics, Local; Bradycardia; Bupivacaine; Female; Heart Rate, Fe

1998
[Cardiorespiratory arrest: a rare complication of subdural block].
    Revista espanola de anestesiologia y reanimacion, 2002, Volume: 49, Issue:2

    Topics: Aged; Anesthesia, Epidural; Anesthetics, Local; Apnea; Arthroplasty, Replacement, Hip; Bradycardia;

2002
The use of ephedrine for prevention of arterial hypotension during epidural blockade. A study of the central circulation after subcutaneous premedication.
    Acta anaesthesiologica Scandinavica. Supplementum, 1978, Volume: 66, Issue:66

    Topics: Adult; Aged; Anesthesia, Epidural; Blood Pressure; Bradycardia; Bupivacaine; Cardiac Output; Ephedri

1978
[Spinal anaesthesia using bupivacain--clinical experience of more than 6000 cases (author's transl)].
    Der Anaesthesist, 1979, Volume: 28, Issue:8

    Topics: Aged; Anesthesia, Spinal; Arrhythmias, Cardiac; Bradycardia; Bupivacaine; Dyspnea; Epinephrine; Fema

1979
[Notes on the paper by J. Owusu-afram and R. Schiffter: Bulbar brain syndrome during epidrual anesthesia with bupivaccaine].
    Der Anaesthesist, 1978, Volume: 27, Issue:7

    Topics: Anesthesia, Epidural; Bradycardia; Bupivacaine; Dyspnea; Humans; Hypotension

1978
[Critical evaluation of paracervical anaesthesia in obstetrics (personal observations in 8038 cases) (author's transl)].
    Geburtshilfe und Frauenheilkunde, 1975, Volume: 35, Issue:10

    Topics: Anesthesia, Obstetrical; Anesthesia, Spinal; Bradycardia; Bupivacaine; Cervix Uteri; Cesarean Sectio

1975
[Perinatal deaths associated with paracervical anesthesia (author's transl)].
    Zeitschrift fur Geburtshilfe und Perinatologie, 1975, Volume: 179, Issue:5

    Topics: Adult; Anesthesia, Obstetrical; Anesthetics; Anesthetics, Local; Apgar Score; Bradycardia; Bupivacai

1975
Foetal bradycardia during caudal analgesia: A discussion of possible causative factors.
    British journal of anaesthesia, 1976, Volume: 48, Issue:5

    Topics: Adult; Anesthesia, Caudal; Anesthesia, Epidural; Bradycardia; Bupivacaine; Female; Fetal Diseases; F

1976
Wenckebach type heart block following spinal anaesthesia for caesarean section.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1992, Volume: 39, Issue:10

    Topics: Adult; Anesthesia, Obstetrical; Anesthesia, Spinal; Arrhythmia, Sinus; Bradycardia; Bupivacaine; Ces

1992
Succinylcholine does not worsen bupivacaine-induced cardiotoxicity in pentobarbital-anaesthetized dogs.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1992, Volume: 39, Issue:2

    Topics: Anesthesia, Intravenous; Animals; Aorta; Blood Pressure; Bradycardia; Bundle of His; Bupivacaine; Do

1992
Development of a high block in an infant during an epidural bupivacaine infusion.
    Anaesthesia and intensive care, 1991, Volume: 19, Issue:4

    Topics: Analgesia, Epidural; Anesthesia, Epidural; Bradycardia; Bupivacaine; Humans; Infant; Kidney; Male; R

1991
Haemodynamic decompensation during caesarean section.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1989, Volume: 36, Issue:3 Pt 1

    Topics: Adult; Anesthesia, Epidural; Anesthesia, Obstetrical; Apnea; Bradycardia; Bupivacaine; Cesarean Sect

1989
[Complications of spinal anesthesia with 1% hyperbaric bupivacaine].
    Minerva anestesiologica, 1987, Volume: 53, Issue:9

    Topics: Adolescent; Adult; Anesthesia, Spinal; Bradycardia; Bupivacaine; Child; Female; Glucose Solution, Hy

1987
Intravenous regional anaesthesia for foot surgery.
    Acta anaesthesiologica Scandinavica, 1986, Volume: 30, Issue:2

    Topics: Adult; Aged; Anesthesia, Conduction; Anesthesia, Intravenous; Ankle; Bradycardia; Bupivacaine; Dizzi

1986
Cardiovascular toxicity of local anesthetics: an alternative hypothesis.
    Anesthesia and analgesia, 1986, Volume: 65, Issue:5

    Topics: Animals; Arrhythmias, Cardiac; Blood Pressure; Bradycardia; Brain; Bupivacaine; Electric Stimulation

1986
Successful cardiovascular resuscitation after massive intravenous bupivacaine overdosage in anesthetized dogs.
    Anesthesia and analgesia, 1985, Volume: 64, Issue:5

    Topics: Animals; Apnea; Atropine; Bradycardia; Bupivacaine; Dogs; Electrocardiography; Epinephrine; Female;

1985
[Complications of regional anaesthesia and their treatment (author's transl)].
    Munchener medizinische Wochenschrift (1950), 1973, Oct-12, Volume: 115, Issue:41

    Topics: Adrenal Cortex Hormones; Anesthesia, Local; Apnea; Barbiturates; Bradycardia; Bupivacaine; Diagnosis

1973
[Paracervical block and its effect on fetus].
    Zeitschrift fur praktische Anasthesie und Wiederbelebung, 1970, Volume: 5, Issue:3

    Topics: Anesthesia, Conduction; Anesthesia, Obstetrical; Bradycardia; Bupivacaine; Cervix Uteri; Female; Fet

1970
Continuous lumbar epidural analgesia during labor and delivery.
    Acta anaesthesiologica Belgica, 1974, Volume: 25, Issue:1

    Topics: Adult; Anesthesia, Epidural; Anesthesia, Obstetrical; Back Pain; Bradycardia; Bupivacaine; Female; F

1974
[Para-cervical block in obstetrics. Preliminary studies on bupivacaine and the use of magnesium sulfate in the control of fetal bradycardia].
    L'union medicale du Canada, 1972, Volume: 101, Issue:2

    Topics: Adolescent; Adult; Anesthesia, Conduction; Anesthesia, Obstetrical; Blood Pressure; Bradycardia; Bup

1972
Lumbar epidural analgesia in labour. I. Acid-base balance and clinical condition of mother, fetus and newborn child.
    Acta obstetricia et gynecologica Scandinavica, 1974, Volume: 53, Issue:1

    Topics: Acidosis; Adult; Anesthesia, Epidural; Anesthesia, Obstetrical; Blood; Body Temperature; Bradycardia

1974
[The effect of paracervical block on the fetus].
    Der Anaesthesist, 1972, Volume: 21, Issue:3

    Topics: Acidosis; Anesthesia, Conduction; Anesthesia, Obstetrical; Anesthetics, Local; Asphyxia Neonatorum;

1972