bupivacaine has been researched along with Blood Loss, Surgical in 43 studies
Bupivacaine: A widely used local anesthetic agent.
1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide : A piperidinecarboxamide obtained by formal condensation of the carboxy group of N-butylpipecolic acid with the amino group of 2,6-dimethylaniline.
bupivacaine : A racemate composed of equimolar amounts of dextrobupivacaine and levobupivacaine. Used (in the form of its hydrochloride hydrate) as a local anaesthetic.
Blood Loss, Surgical: Loss of blood during a surgical procedure.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Our study shows LRSB is effective and safe for laparoscopic abdominal surgery." | 2.84 | Laparoscopic-assisted Rectus Sheath Block as a Novel Technique is Effective and Safe: A Randomized Controlled Trial. ( Ebihara, Y; Hirano, S; Kurashima, Y; Miyazaki, D; Murakami, S; Nakamura, T; Noji, T; Okamura, K; Shichinohe, T; Tsuchikawa, T, 2017) |
| "Levobupivacaine has a vasoconstrictive effect in 0." | 2.77 | Vasoconstrictive and analgesic efficacy of locally infiltrated levobupivacaine in tonsillectomy patients. ( Akin, I; Akkaya, T; Aladag, E; Alicura, S; Ergil, J; Gozaydin, O; Gumus, H; Gunsoy, B, 2012) |
| "The operation time, postoperative pain, amount of intraoperative blood loss, postoperative hemorrhage and complications were assessed." | 2.77 | Comparison of ropivacaine, bupivacaine and lidocaine in the management of post-tonsillectomy pain. ( Kapusuz, Z; Ozkiriş, M; Saydam, L, 2012) |
| "In 2001, we reported a novel technique for pediatric circumcision that has proved to be fast, reliable, and safe during the past 4 years, with good cosmetic results." | 2.75 | Adult template circumcision: a prospective, randomized, patient-blinded, comparative study evaluating the safety and efficacy of a novel circumcision device. ( Decastro, B; Gurski, J; Peterson, A, 2010) |
| "Visual analog scale was used for postoperative pain assessment." | 2.75 | Does preincisional injection of levobupivacaine with epinephrine have any benefits for children undergoing tonsillectomy? An intraindividual evaluation. ( Cinar, F; Hanci, V; Tas, E; Turan, IO; Ugur, MB; Yigit, VB, 2010) |
| "Postoperative pain was assessed using visual analogue scales and verbal response scores at 3, 6, 10 and 24 h post-infiltration." | 2.69 | The efficacy of bupivacaine with adrenaline in reducing pain and bleeding associated with breast reduction: a prospective trial. ( Asplund, O; Hayes, M; Metaxotos, NG, 1999) |
| "Postoperative pain was assessed at regular intervals by using three methods: (1) use of a visual analogue scale by parents and nurses to estimate pain; (2) postoperative need for nalbuphine as analgesic; (3) the Hannallah-Broadman semi-objective pain score (including crying, anxiety, restlessness, and changes in blood pressure)." | 2.68 | [Local infiltration of epinephrine and bupivacaine before tonsillectomy]. ( Erb, T; Frei, F; Kern, C; Strub, KA; Tschopp, K, 1996) |
| "To quantify the surgical blood loss during canine enucleation and to investigate the relationship between this and any patient, surgical, and anesthetic factors." | 1.91 | Estimation of the intraoperative blood loss in dogs undergoing enucleation. ( Baines, SJ; Carrozza, R; Grundon, RA; Heinrich, CL; Lenihan, E; Linn-Pearl, RN; Stevens, EJ; Walsh, K, 2023) |
| "Demographic information, postoperative pain scores (visual analog scale), analgesic consumption, length of stay, and complications were retrospectively collected." | 1.43 | The Role of Liposomal Bupivacaine in Reduction of Postoperative Pain After Transforaminal Lumbar Interbody Fusion: A Clinical Study. ( Burke, SM; Desilier, A; Hwang, SW; Kim, J; Kryzanski, JT; Liu, PP; Qu, E; Riesenburger, RI; Roberts, RJ; Roguski, M, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 8 (18.60) | 18.2507 |
| 2000's | 16 (37.21) | 29.6817 |
| 2010's | 15 (34.88) | 24.3611 |
| 2020's | 4 (9.30) | 2.80 |
| Authors | Studies |
|---|---|
| Ceynowa, M | 1 |
| Sikora, T | 1 |
| Rocławski, M | 1 |
| Treder, M | 1 |
| Kolarz, K | 1 |
| Pankowski, R | 1 |
| Mazurek, T | 1 |
| Lenihan, E | 1 |
| Baines, SJ | 1 |
| Linn-Pearl, RN | 1 |
| Grundon, RA | 1 |
| Carrozza, R | 1 |
| Stevens, EJ | 1 |
| Heinrich, CL | 1 |
| Walsh, K | 1 |
| Ackerman, LL | 1 |
| Snider, AA | 1 |
| Ye, J | 1 |
| Rezniczek, GA | 1 |
| Hecken, JM | 1 |
| Rehman, S | 1 |
| Dogan, A | 1 |
| Tempfer, CB | 1 |
| Hilal, Z | 1 |
| Shimizu, Y | 1 |
| Nagasao, T | 1 |
| Taneda, H | 1 |
| Sakamoto, Y | 1 |
| Asou, T | 1 |
| Imanishi, N | 1 |
| Kishi, K | 1 |
| Baumunk, D | 1 |
| Strang, CM | 1 |
| Kropf, S | 1 |
| Schäfer, M | 1 |
| Schrader, M | 1 |
| Weikert, S | 1 |
| Cash, H | 1 |
| Breckwoldt, J | 1 |
| Miller, K | 1 |
| Hachenberg, T | 1 |
| Schostak, M | 1 |
| Erdogan, BA | 1 |
| Aydin, S | 1 |
| Paksoy, M | 1 |
| Sanli, A | 1 |
| Sevim, S | 1 |
| Bayram, A | 1 |
| Doğan, M | 1 |
| Cihan, C | 1 |
| Karataş, D | 1 |
| Gökahmetoğlu, G | 1 |
| Özcan, I | 1 |
| Kim, J | 1 |
| Burke, SM | 1 |
| Kryzanski, JT | 1 |
| Roberts, RJ | 1 |
| Roguski, M | 1 |
| Qu, E | 1 |
| Hwang, SW | 1 |
| Liu, PP | 1 |
| Desilier, A | 1 |
| Riesenburger, RI | 1 |
| Miyazaki, D | 1 |
| Shichinohe, T | 1 |
| Ebihara, Y | 1 |
| Kurashima, Y | 1 |
| Murakami, S | 1 |
| Noji, T | 1 |
| Nakamura, T | 1 |
| Tsuchikawa, T | 1 |
| Okamura, K | 1 |
| Hirano, S | 1 |
| Unterrainer, AF | 1 |
| Al-Schameri, AR | 1 |
| Piotrowski, WP | 1 |
| Krombholz-Reindl, MA | 1 |
| Schmid, AL | 1 |
| Hitzl, W | 1 |
| Anderson, LA | 1 |
| Engel, GM | 1 |
| Bruckner, JD | 1 |
| Stoddard, GJ | 1 |
| Peters, CL | 1 |
| Barkhuysen, R | 1 |
| Meijer, GJ | 1 |
| Soehardi, A | 1 |
| Merkx, MA | 1 |
| Borstlap, WA | 1 |
| Bergé, SJ | 1 |
| Bronkhorst, EM | 1 |
| Hoppenreijs, TJ | 1 |
| Tikuisis, R | 2 |
| Miliauskas, P | 2 |
| Samalavicius, NE | 1 |
| Zurauskas, A | 2 |
| Sruogis, A | 1 |
| Decastro, B | 1 |
| Gurski, J | 1 |
| Peterson, A | 1 |
| Tas, E | 1 |
| Hanci, V | 1 |
| Ugur, MB | 1 |
| Turan, IO | 1 |
| Yigit, VB | 1 |
| Cinar, F | 1 |
| Villegas Becerril, E | 1 |
| Pérula de Torres, L | 1 |
| Bergillos Arillo, M | 1 |
| Villegas del Cuvillo, C | 1 |
| Bastian, D | 1 |
| Tamburstuen, MV | 1 |
| Lyngstadaas, SP | 1 |
| Reikerås, O | 1 |
| Wolthuis, AM | 1 |
| Penninckx, F | 1 |
| Fieuws, S | 1 |
| D'Hoore, A | 1 |
| Ergil, J | 1 |
| Akkaya, T | 1 |
| Gozaydin, O | 1 |
| Gunsoy, B | 1 |
| Alicura, S | 1 |
| Aladag, E | 1 |
| Gumus, H | 1 |
| Akin, I | 1 |
| Ozkiriş, M | 1 |
| Kapusuz, Z | 1 |
| Saydam, L | 1 |
| Türker, G | 1 |
| Uçkunkaya, N | 1 |
| Yavaşçaoğlu, B | 1 |
| Yilmazlar, A | 1 |
| Ozçelik, S | 1 |
| Caesar, RH | 1 |
| McNab, AA | 1 |
| Salonia, A | 1 |
| Crescenti, A | 1 |
| Suardi, N | 1 |
| Memmo, A | 1 |
| Naspro, R | 1 |
| Bocciardi, AM | 1 |
| Colombo, R | 1 |
| Da Pozzo, LF | 1 |
| Rigatti, P | 1 |
| Montorsi, F | 1 |
| Lombardi, AV | 1 |
| Berend, KR | 1 |
| Mallory, TH | 1 |
| Dodds, KL | 1 |
| Adams, JB | 1 |
| Cicenas, S | 1 |
| Eidukevicius, R | 1 |
| Jackevicius, A | 1 |
| Ginström, R | 1 |
| Silvola, J | 1 |
| Saarnivaara, L | 1 |
| Benatar-Haserfaty, J | 1 |
| Monleón de la Calle, MP | 1 |
| Sanz-López, A | 1 |
| Muriel García, A | 1 |
| Kongnyuy, EJ | 1 |
| van den Broek, N | 1 |
| Wiysonge, CS | 1 |
| Demiraran, Y | 1 |
| Ozturk, O | 1 |
| Guclu, E | 1 |
| Iskender, A | 1 |
| Ergin, MH | 1 |
| Tokmak, A | 1 |
| Gregorio, LV | 1 |
| Giglio, FP | 1 |
| Sakai, VT | 1 |
| Modena, KC | 1 |
| Colombini, BL | 1 |
| Calvo, AM | 1 |
| Sipert, CR | 1 |
| Dionísio, TJ | 1 |
| Lauris, JR | 1 |
| Faria, FA | 1 |
| Trindade Junior, AS | 1 |
| Santos, CF | 1 |
| Mottura, AA | 1 |
| Strub, KA | 1 |
| Tschopp, K | 1 |
| Frei, F | 1 |
| Kern, C | 1 |
| Erb, T | 1 |
| Kakiuchi, M | 1 |
| Costas-Gastiaburo, LA | 1 |
| Rajah, V | 1 |
| Rubin, J | 1 |
| Liddle, AM | 1 |
| Hall, AP | 1 |
| Arrowsmith, J | 1 |
| Smith, G | 1 |
| Metaxotos, NG | 1 |
| Asplund, O | 1 |
| Hayes, M | 1 |
| Beausang, E | 1 |
| Orr, D | 1 |
| Shah, M | 1 |
| Dunn, KW | 1 |
| Davenport, PJ | 1 |
| Niemi, TT | 1 |
| Pitkänen, M | 1 |
| Syrjälä, M | 1 |
| Rosenberg, PH | 1 |
| Mallinder, PA | 1 |
| Hall, JE | 1 |
| Bergin, FG | 1 |
| Royle, P | 1 |
| Leaper, DJ | 1 |
| Davies, MJ | 1 |
| Arhanghelschi, I | 1 |
| Grauer, R | 1 |
| Heard, G | 1 |
| Scott, DA | 1 |
| Twyman, R | 1 |
| Kirwan, T | 1 |
| Fennelly, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Large Loop Excision of the Transformation Zone (LLETZ) With Versus Without Intraoperative Application of Lugol's Iodine in Women With Cervical Dysplasia: a Prospective Randomized Trial[NCT05132114] | 216 participants (Anticipated) | Interventional | 2022-01-17 | Recruiting | |||
| Large Loop Excision of the Transformatione Zone Under General Versus Local Anesthesia: a Randomized Trial.[NCT03494686] | 229 participants (Actual) | Interventional | 2018-04-03 | Completed | |||
| Comparison of Peritonsillar Dexamethasone-bupivacaine and Bupivacaine Infiltration for Tonsillectomy Pain Relief in Children:a Randomized,Double Blind,Controlled Study.[NCT03443778] | Phase 4 | 120 participants (Anticipated) | Interventional | 2017-12-15 | Active, not recruiting | ||
| Postoperative Analgesia After Cardiac Surgery - A Double-Blind, Prospective and Randomized Comparison of Wound Infiltration With Liposomal Bupivacaine and Bupivacaine Hydrochloride[NCT03270514] | Phase 3 | 60 participants (Actual) | Interventional | 2018-11-15 | Completed | ||
| A Double Blind Randomized Control Trial on the Efficacy of Periarticular Levo Bupivicaine Injection Following Primary Hip Arthroplasty[NCT01106001] | Phase 4 | 91 participants (Actual) | Interventional | 2008-09-30 | Completed | ||
| Peri-articular Injections Containing a Corticosteroid During Total Knee Arthroplasty[NCT00492973] | 101 participants (Actual) | Interventional | 2006-03-31 | Completed | |||
| The Role of Intra-Operative Intracapsular Blocks in Post-Operative Pain Management Following Total Knee Arthroplasty: A Double-Blinded Randomized Controlled Trial[NCT00620828] | Phase 4 | 67 participants (Actual) | Interventional | 2007-05-31 | Completed | ||
| Continuous Femoral Nerve Block Versus Local-wound Infiltration Analgesia For Patients Receiving Unilateral Total Knee Arthroplasty --- A Randomized Controlled Trial[NCT02284620] | Phase 4 | 320 participants (Anticipated) | Interventional | 2015-01-31 | Recruiting | ||
| The Safety of Liposomal Bupivacaine in Simultaneous Bilateral Total Knee Arthroplasty[NCT02349542] | Phase 4 | 20 participants (Actual) | Interventional | 2015-01-31 | Completed | ||
| Ultrasound-Guided Submandibular Parapharyngeal Glossopharyngeal Nerve Block for Post -Tonsillectomy Pain Relief in Adults. A Prospective Randomized Study[NCT05435833] | 50 participants (Actual) | Interventional | 2022-11-05 | Completed | |||
| Evaluation of Articaine 4% Versus Mepivacaine 2% for Surgery of Molars Thirds: Splint-mouth Randomized Double Blind Controlled Clinical Trial.[NCT03384160] | 7 participants (Actual) | Interventional | 2017-12-07 | Completed | |||
| Efficacy of a Single-shot Wound Infiltration With Bupivacaine/Adrenalin During Cesarean Section in Reducing Postoperative Pain. A Randomized Prospective Controlled Trial[NCT03395912] | 288 participants (Actual) | Interventional | 2018-01-25 | Completed | |||
| Blood Volume Analysis of Total Hip Arthroplasty Patients Under Hypotensive Anesthesia[NCT02148809] | 14 participants (Actual) | Interventional | 2014-05-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Readmission to hospital will be noted (NCT03270514)
Timeframe: From end of surgery assessed up to 30 days post-operatively
| Intervention | Participants (Count of Participants) |
|---|---|
| Exparel Injectable Product | 3 |
| Bupivacaine Hydrochloride | 3 |
Mortality will be noted at specific timepoints (NCT03270514)
Timeframe: From end of surgery assessed up to 30 days post-operatively
| Intervention | Participants (Count of Participants) |
|---|---|
| Exparel Injectable Product | 0 |
| Bupivacaine Hydrochloride | 1 |
Episodes of NIV such as upper airway masks or similar devices will be quantified (NCT03270514)
Timeframe: From time of end of surgery to 72 hours post-operatively or until hospital discharge
| Intervention | Participants (Count of Participants) |
|---|---|
| Exparel Injectable Product | 6 |
| Bupivacaine Hydrochloride | 5 |
Patient will give an assessment regarding pain management on a scale of 0 - 10 with 0 indicating the lowest satisfaction with pain management and 10 indicating the highest satisfaction with pain management (NCT03270514)
Timeframe: Given at the time of discharge up to 30 days post-operatively
| Intervention | score on a scale (Median) |
|---|---|
| Exparel Injectable Product | 10 |
| Bupivacaine Hydrochloride | 10 |
The time it takes until patient ambulates will be measured (NCT03270514)
Timeframe: From time of end of surgery to time of mobilization up to 72 hours or discharge, *assessed up to 120 hours*
| Intervention | hours (Median) |
|---|---|
| Exparel Injectable Product | 42 |
| Bupivacaine Hydrochloride | 45 |
The time it takes until the patient is able to/medically cleared to consume food or liquid will be measured (NCT03270514)
Timeframe: From time of end of surgery to time of oral intake up to 72 hours post-operatively or until hospital discharge
| Intervention | hours (Median) |
|---|---|
| Exparel Injectable Product | 7 |
| Bupivacaine Hydrochloride | 5.6 |
The time it takes until the patient advances from bedrest to out of bed (OOB) to chair will be measured (NCT03270514)
Timeframe: From time of end of surgery to time of mobilization up to 72 hours post-operatively
| Intervention | hours (Median) |
|---|---|
| Exparel Injectable Product | 16 |
| Bupivacaine Hydrochloride | 16 |
Whether a patient experiences at least one episode of nausea and emesis will be measured (NCT03270514)
Timeframe: From time of end of surgery to 72 hours post-operatively
| Intervention | Participants (Count of Participants) |
|---|---|
| Exparel Injectable Product | 3 |
| Bupivacaine Hydrochloride | 9 |
Instances of re-intubation will be recorded (NCT03270514)
Timeframe: From time of end of surgery to patient discharge up to one week
| Intervention | Participants (Count of Participants) |
|---|---|
| Exparel Injectable Product | 3 |
| Bupivacaine Hydrochloride | 3 |
The time it takes until the patient is extubated post-operatively will be measured (NCT03270514)
Timeframe: From the end of surgery until the patient is extubated up to 72 hours post-operatively
| Intervention | hours (Median) |
|---|---|
| Exparel Injectable Product | 3.85 |
| Bupivacaine Hydrochloride | 3.47 |
Frequency of incentive spirometry will be measured (NCT03270514)
Timeframe: From time of end of surgery to 72 hours post-operatively
| Intervention | Participants (Count of Participants) |
|---|---|
| Exparel Injectable Product | 29 |
| Bupivacaine Hydrochloride | 31 |
Length of both hospital and ICU stay will be measured (NCT03270514)
Timeframe: From date of surgery assessed up to 30 day post-operatively
| Intervention | days (Median) | |
|---|---|---|
| Length of ICU stay | Length of postoperative hospital stay | |
| Bupivacaine Hydrochloride | 1.71 | 6 |
| Exparel Injectable Product | 1.51 | 7 |
Postoperative pain scores evaluated by numeric rating scale or (NRS) where 0- no pain and 10- worst pain, at rest and at movement (NCT03270514)
Timeframe: NRS scores will be evaluated every 4 hours until 24 hours post-operatively, every 8 hours until 48 hours post-operatively, and every 12 hours for 72 hours post-operatively
| Intervention | score on a scale (Mean) | |||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 4hrs. at rest | 4hrs. with movement | 8hrs. at rest | 8hrs. with movement | 12hrs. at rest | 12hrs. with movement | 16hrs. at rest | 16hrs. with movement | 20hrs. at rest | 20hrs. with movement | 24hrs. at rest | 24hrs. with movement | 32hrs. at rest | 32hrs. with movement | 40hrs. at rest | 40hrs. with movement | 48hrs. at rest | 48hrs. with movement | 60hrs. at rest | 60hrs. with movement | 72hrs. at rest | 72hrs. with movement | |
| Bupivacaine Hydrochloride | 5.03 | 6.64 | 4.996 | 6.6 | 4.962 | 6.56 | 4.928 | 6.52 | 4.894 | 6.48 | 4.86 | 6.44 | 4.792 | 6.32 | 4.724 | 6.24 | 4.656 | 6.16 | 4.554 | 6.04 | 4.452 | 5.92 |
| Exparel Injectable Product | 4.7482 | 5.75 | 4.7262 | 5.74 | 4.7042 | 5.73 | 4.6822 | 5.72 | 4.6602 | 5.71 | 4.6382 | 5.7 | 4.5942 | 5.68 | 4.5282 | 5.66 | 4.4622 | 5.64 | 4.3742 | 5.61 | 4.2862 | 5.58 |
Stress response suppression as a result of treatment will be evaluated by comparing hormone levels between the groups. Serum cortisol levels will be taken to measure this. (NCT03270514)
Timeframe: Measured 8, 48, and 72 hours post-operatively
| Intervention | µg/dL (Median) | ||
|---|---|---|---|
| 8 hours postoperatively | 48 hours postoperatively | 72 hours postoperatively | |
| Bupivacaine Hydrochloride | 36.5 | 19 | 17 |
| Exparel Injectable Product | 30 | 15 | 16 |
All narcotics administered in the first 0-8, 8-24, 24-48, and 48-72 hours and the total narcotics administered in the 0-72 hours postoperative period(PCA narcotics, nurse-administered IV narcotics, and oral narcotics). All narcotics will be converted to total IV morphine equivalent for comparison between two groups. (NCT03270514)
Timeframe: 0-72 hours post-operative period
| Intervention | oral morphine equivalents in mg (Median) | ||||
|---|---|---|---|---|---|
| 0-8 hours | 8-24 hours | 24-48 hours | 48-72 hours | 0-72 hours | |
| Bupivacaine Hydrochloride | 10 | 34.5 | 45 | 26.5 | 105 |
| Exparel Injectable Product | 15 | 45 | 45 | 15 | 139 |
(NCT00492973)
Timeframe: Average of 3 days after surgery
| Intervention | mg/day morphine equivalant (Mean) |
|---|---|
| Control Group | 47.8 |
| Corticosteroid | 46.0 |
(NCT00492973)
Timeframe: any point during the first postoperative year
| Intervention | Number of participants with complication (Number) |
|---|---|
| Control Group | 0 |
| Corticosteroid | 3 |
(NCT00492973)
Timeframe: 3 months
| Intervention | degrees (Mean) |
|---|---|
| Control Group | 112.5 |
| Corticosteroid | 112.4 |
The Knee Society Score is on a scale of 0 to 100, with 0 being the worst possible score, and 100 being the best possible score. The Knee Society Score takes into account subjective patient reports of pain and functional ability as well as clinical measures of passive knee range of motion. (NCT00492973)
Timeframe: 3 months postoperative
| Intervention | units on a scale (Mean) |
|---|---|
| Control Group | 87.1 |
| Corticosteroid | 83.3 |
(NCT00492973)
Timeframe: days after surgery
| Intervention | days (Mean) |
|---|---|
| Control Group | 3.5 |
| Corticosteroid | 2.6 |
Ambulation distance walked by participants 24-hours post-operatively (NCT00620828)
Timeframe: 24 hours post-op
| Intervention | Feet (Median) |
|---|---|
| Block Group | 38.4 |
| Control Group | 26.4 |
Participants were asked to rate their pain on a scale of 0 to 10 at all time intervals up to 24 hours post-injection. Scores were organized into the following categories: 3 or less (mild pain), 4 to 6 (moderate pain), 7 or higher (severe pain). (NCT00620828)
Timeframe: Post-anesthesia care unit (PACU), 4 hours, 8 hours, 12 hours and 24 hours post-injection
| Intervention | units on a scale (Mean) | ||||
|---|---|---|---|---|---|
| PACU | 4 hours | 8 hours | 12 hours | 24 hours | |
| Block Group | 0.67 | 2.5 | 3.8 | 3.2 | 3.9 |
| Control Group | 1.6 | 3.6 | 4.9 | 3.9 | 4.9 |
Straight Leg Raise (SLR): number of people that can perform a SLR at designated intervals (NCT00620828)
Timeframe: 4 hours, 8 hours, 12 hours and 24 hours post-op
| Intervention | participants (Number) | |||
|---|---|---|---|---|
| SLR 4 hrs | SLR 8 hrs | SLR 12 hrs | SLR 24 hrs | |
| Block Group | 4 | 13 | 12 | 13 |
| Control Group | 5 | 5 | 5 | 6 |
Knee extension and knee flexion measured at 24-hours post-operatively for patient cohort (NCT00620828)
Timeframe: 24 hours post-op
| Intervention | degrees (Mean) | |
|---|---|---|
| Knee extension | Knee flexion | |
| Block Group | 7.8 | 71.5 |
| Control Group | 7.0 | 69.6 |
The PCA total dose at the 4-hour, 8-hour, 12-hour and 24-hour post-operative time points. (NCT00620828)
Timeframe: 4 hours to 24 hours post-op
| Intervention | micrograms (Mean) | |||
|---|---|---|---|---|
| 4 hours | 8 hours | 12 hours | 24 hours | |
| Block Group | 22.4 | 95.6 | 173.4 | 418.5 |
| Control Group | 43.7 | 126.6 | 205.6 | 292.2 |
Number of Participants with Adverse Events (NCT02349542)
Timeframe: Up to 72 hours following injection
| Intervention | participants (Number) |
|---|---|
| Liposomal Bupivacaine | 0 |
Blood samples will be drawn and analyzed to establish levels of bupivacaine detectable in the blood. Blood samples will be drawn at baseline (prior to injection), upon injection, at 15 minutes, 30 minutes, 1 hour, 2 hours, 4 hours, 8 hours, 12 hours, 24 hours, 48 hours, 72 hours post-injection and analyzed to determine levels of bupivacaine present. (NCT02349542)
Timeframe: Up to 72 hours following injection
| Intervention | ug/ml (Mean) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Baseline (Pre-Injection) | Immediately Following Injection | 15 minutes after injection | 30 minutes after injection | 1 hour after injection | 2 hours after injection | 4 hours after injection | 8 hours after injection | 12 hours after injection | 24 hours after injection | 48 hours after injection | 72 hours after injection | |
| Liposomal Bupivacaine | 0 | 0.22 | 0.31 | 0.35 | 0.47 | 0.53 | 0.56 | 0.63 | 0.56 | 0.71 | 0.80 | 0.43 |
"An indicator dilution technique was used to measure the blood volume, plasma volume and red cell blood volume. Approved by the Food and Drug Administration in 1998, the BVA-100 blood volume analyzer (Daxor Corp.) is a semi-automated system for blood volume analysis. Prepared standards and injectates were used. The injectate consists of 31I-labeled HSA (370- 1,295 kBq [10-30 mCi]) in saline.~Measurement was performed directly before surgery in the holding area and 6 hours after surgery.~Each time, before injection of the tracer a baseline sample was taken. After injection of the tracer via standard i.v. line, the first sample was drawn from an arterial line after 12 minutes waiting time. Afterwards every 6 minutes a sample was taken. In a whole 5 samples were sent for analysis to Daxor® Corp.. Each sample is counted in duplicate." (NCT02148809)
Timeframe: preoperative and 6 hours postoperatively
| Intervention | ml (Mean) |
|---|---|
| Pilot Study | 214 |
The primary outcome is the change in total blood volume (TBV) during the first 6 hours after primary THA utilizing hypotensive anesthesia. Preoperative TBV will be compared to values 6 hours postoperatively. (NCT02148809)
Timeframe: preoperatively and 6 hours postoperatively
| Intervention | ml (Mean) |
|---|---|
| Pilot Study | 487 |
1 review available for bupivacaine and Blood Loss, Surgical
| Article | Year |
|---|---|
A systematic review of randomized controlled trials to reduce hemorrhage during myomectomy for uterine fibroids.
Topics: Blood Loss, Surgical; Bupivacaine; Combined Modality Therapy; Female; Gynecologic Surgical Procedure | 2008 |
27 trials available for bupivacaine and Blood Loss, Surgical
| Article | Year |
|---|---|
Syringe or mask? Loop electrosurgical excision procedure under local or general anesthesia: a randomized trial.
Topics: Adenocarcinoma in Situ; Adult; Anesthesia, General; Anesthesia, Local; Anesthetics, Inhalation; Anes | 2020 |
Syringe or mask? Loop electrosurgical excision procedure under local or general anesthesia: a randomized trial.
Topics: Adenocarcinoma in Situ; Adult; Anesthesia, General; Anesthesia, Local; Anesthetics, Inhalation; Anes | 2020 |
Syringe or mask? Loop electrosurgical excision procedure under local or general anesthesia: a randomized trial.
Topics: Adenocarcinoma in Situ; Adult; Anesthesia, General; Anesthesia, Local; Anesthetics, Inhalation; Anes | 2020 |
Syringe or mask? Loop electrosurgical excision procedure under local or general anesthesia: a randomized trial.
Topics: Adenocarcinoma in Situ; Adult; Anesthesia, General; Anesthesia, Local; Anesthetics, Inhalation; Anes | 2020 |
Impact of thoracic epidural analgesia on blood loss in radical retropubic prostatectomy.
Topics: Administration, Intravenous; Aged; Analgesia, Epidural; Analgesics, Opioid; Anesthesia, General; Ane | 2014 |
Efficacy of preincisional levobupivacaine for adult tonsillectomy patients.
Topics: Adolescent; Adult; Anesthetics, Local; Blood Loss, Surgical; Bupivacaine; Female; Humans; Injections | 2014 |
Post-op pain and blood loss in total knee arthroplasty: an RCT using periarticular injection with diclofenac-based multimodal drugs.
Topics: Aged; Aged, 80 and over; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthetics, Local; Anti | 2014 |
The Efficacy of Levobupivacaine Hydrochloride-Dexamethasone Infiltration for Post-Tonsillectomy Pain in Adults.
Topics: Adolescent; Adult; Analgesics; Anesthetics, Local; Anti-Inflammatory Agents; Blood Loss, Surgical; B | 2015 |
Laparoscopic-assisted Rectus Sheath Block as a Novel Technique is Effective and Safe: A Randomized Controlled Trial.
Topics: Aged; Anesthetics, Local; Blood Loss, Surgical; Bupivacaine; Female; Humans; Injections, Intramuscul | 2017 |
Opioid sparing effect of epidural levobupivacaine on postoperative pain treatment in major spinal surgery.
Topics: Aged; Analgesia, Epidural; Analgesics, Opioid; Anesthetics, Local; Blood Loss, Surgical; Bupivacaine | 2008 |
The effect of a single dose of bupivacaine on donor site pain after anterior iliac crest bone harvesting.
Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Alveolar Ridge Augmentation; Analgesics, Non-Narcotic | 2010 |
Epidural and general anesthesia versus general anesthesia in radical prostatectomy.
Topics: Anesthesia, Epidural; Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Intravenous; Anesth | 2009 |
Adult template circumcision: a prospective, randomized, patient-blinded, comparative study evaluating the safety and efficacy of a novel circumcision device.
Topics: Adolescent; Adult; Aged; Blood Loss, Surgical; Bupivacaine; Circumcision, Male; Equipment Design; Hu | 2010 |
Does preincisional injection of levobupivacaine with epinephrine have any benefits for children undergoing tonsillectomy? An intraindividual evaluation.
Topics: Adolescent; Anesthetics, Local; Blood Loss, Surgical; Bupivacaine; Child; Epinephrine; Female; Human | 2010 |
[Evaluation of topical vasoconstrictors in pterygium surgery and their role in reducing intraoperative bleeding].
Topics: Adjuvants, Anesthesia; Administration, Topical; Anesthetics, Local; Blood Loss, Surgical; Bupivacain | 2011 |
Vasoconstrictive and analgesic efficacy of locally infiltrated levobupivacaine in tonsillectomy patients.
Topics: Anesthesia, General; Anesthetics, Local; Blood Loss, Surgical; Bupivacaine; Child; Double-Blind Meth | 2012 |
Comparison of ropivacaine, bupivacaine and lidocaine in the management of post-tonsillectomy pain.
Topics: Adenoidectomy; Administration, Topical; Adolescent; Age Factors; Amides; Anesthetics, Local; Blood L | 2012 |
Comparison of the catheter-technique psoas compartment block and the epidural block for analgesia in partial hip replacement surgery.
Topics: Aged; Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthetics, Local; Ar | 2003 |
General versus spinal anesthesia in patients undergoing radical retropubic prostatectomy: results of a prospective, randomized study.
Topics: Adenocarcinoma; Aged; Anesthesia Recovery Period; Anesthesia, General; Anesthesia, Spinal; Blood Los | 2004 |
Local bupivacaine-epinephrine infiltration combined with general anesthesia for adult tonsillectomy.
Topics: Adenoidectomy; Adolescent; Adult; Anesthesia, General; Anesthesia, Local; Anesthetics, Local; Blood | 2005 |
Vasoconstriction and analgesic efficacy of locally infiltrated levobupivacaine for nasal surgery.
Topics: Adult; Analgesics; Anesthetics, Local; Blood Loss, Surgical; Bupivacaine; Double-Blind Method; Drug | 2008 |
A comparison of the clinical anesthetic efficacy of 4% articaine and 0.5% bupivacaine (both with 1:200,000 epinephrine) for lower third molar removal.
Topics: Adolescent; Adult; Anesthesia Recovery Period; Anesthesia, Dental; Anesthesia, Local; Anesthetics, L | 2008 |
[Local infiltration of epinephrine and bupivacaine before tonsillectomy].
Topics: Adenoidectomy; Anesthesia, Local; Blood Loss, Surgical; Bupivacaine; Child; Child, Preschool; Epinep | 1996 |
Reduction of blood loss during spinal surgery by epidural blockade under normotensive general anesthesia.
Topics: Anesthesia, Epidural; Anesthesia, General; Anesthetics, Local; Blood Loss, Surgical; Bupivacaine; Ce | 1997 |
Tonsillectomy and the value of peritonsillar infiltrations.
Topics: Adolescent; Adult; Anesthetics, Local; Blood Loss, Surgical; Blood Volume; Bupivacaine; Double-Blind | 1998 |
Effect of infiltration with ropivacaine on blood loss during reduction mammoplasty.
Topics: Adult; Amides; Anesthetics, Local; Blood Loss, Surgical; Bupivacaine; Double-Blind Method; Drug Comb | 1998 |
The efficacy of bupivacaine with adrenaline in reducing pain and bleeding associated with breast reduction: a prospective trial.
Topics: Adult; Anesthetics, Local; Blood Loss, Surgical; Bupivacaine; Double-Blind Method; Drug Therapy, Com | 1999 |
Subcutaneous adrenaline infiltration in paediatric burn surgery.
Topics: Anesthetics, Local; Blood Loss, Surgical; Bupivacaine; Burns; Child; Child, Preschool; Epinephrine; | 1999 |
Comparison of hypotensive epidural anaesthesia and spinal anaesthesia on blood loss and coagulation during and after total hip arthroplasty.
Topics: Aged; Anesthesia, Epidural; Anesthesia, Spinal; Anesthetics, Local; Arthroplasty, Replacement, Hip; | 2000 |
A comparison of opiate- and epidural-induced alterations in splanchnic blood flow using intra-operative gastric tonometry.
Topics: Aged; Analgesia, Epidural; Analgesics, Opioid; Anesthetics, Local; Blood Loss, Surgical; Bupivacaine | 2000 |
15 other studies available for bupivacaine and Blood Loss, Surgical
| Article | Year |
|---|---|
Local infiltration analgesia with bupivacaine and adrenaline does not reduce perioperative blood loss in total hip arthroplasty.
Topics: Aged; Analgesia; Anesthetics, Local; Arthroplasty, Replacement, Hip; Blood Loss, Surgical; Body Mass | 2021 |
Estimation of the intraoperative blood loss in dogs undergoing enucleation.
Topics: Acepromazine; Animals; Blood Loss, Surgical; Bupivacaine; Dog Diseases; Dogs; Nerve Block | 2023 |
Use of Subcutaneous Injection of Epinephrine and Triamcinolone with Tranexamic Acid Reduces Blood Loss, Transfusion Rates, and Length of Stay in Open Sagittal Craniosynostosis Repair.
Topics: Antifibrinolytic Agents; Blood Loss, Surgical; Bupivacaine; Craniosynostoses; Hemoglobins; Humans; I | 2023 |
Combined usage of intercostal nerve block and tumescent anaesthesia: an effective anaesthesia technique for breast augmentation.
Topics: Adult; Anesthesia, Local; Anesthetics, Local; Blood Loss, Surgical; Bupivacaine; Female; Humans; Int | 2014 |
The Role of Liposomal Bupivacaine in Reduction of Postoperative Pain After Transforaminal Lumbar Interbody Fusion: A Clinical Study.
Topics: Analgesics; Anesthetics, Local; Area Under Curve; Blood Loss, Surgical; Bupivacaine; Case-Control St | 2016 |
Reduced blood loss after total knee arthroplasty with local injection of bupivacaine and epinephrine.
Topics: Aged; Anesthetics, Local; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Bupivacaine; Case-C | 2009 |
LBP and sCD14 patterns in total hip replacement surgery performed during combined spinal/epidural anaesthesia.
Topics: Acute-Phase Proteins; Adult; Aged, 80 and over; Anesthesia, Epidural; Anesthesia, Spinal; Anesthetic | 2011 |
Outcomes for case-matched single-port colectomy are comparable with conventional laparoscopic colectomy.
Topics: Adenoma; Adult; Aged; Analgesics; Blood Loss, Surgical; Bupivacaine; C-Reactive Protein; Colectomy; | 2012 |
External dacryocystorhinostomy and local anesthesia: technique to measure minimized blood loss.
Topics: Aged; Anesthesia, Local; Anesthetics, Combined; Blood Loss, Surgical; Bupivacaine; Conscious Sedatio | 2004 |
Soft tissue and intra-articular injection of bupivacaine, epinephrine, and morphine has a beneficial effect after total knee arthroplasty.
Topics: Aged; Analgesics, Opioid; Analysis of Variance; Anesthetics, Local; Arthroplasty, Replacement, Knee; | 2004 |
Soft tissue and intra-articular injection of bupivacaine, epinephrine, and morphine has a beneficial effect after total knee arthroplasty.
Topics: Aged; Analgesics, Opioid; Analysis of Variance; Anesthetics, Local; Arthroplasty, Replacement, Knee; | 2004 |
Soft tissue and intra-articular injection of bupivacaine, epinephrine, and morphine has a beneficial effect after total knee arthroplasty.
Topics: Aged; Analgesics, Opioid; Analysis of Variance; Anesthetics, Local; Arthroplasty, Replacement, Knee; | 2004 |
Soft tissue and intra-articular injection of bupivacaine, epinephrine, and morphine has a beneficial effect after total knee arthroplasty.
Topics: Aged; Analgesics, Opioid; Analysis of Variance; Anesthetics, Local; Arthroplasty, Replacement, Knee; | 2004 |
Soft tissue and intra-articular injection of bupivacaine, epinephrine, and morphine has a beneficial effect after total knee arthroplasty.
Topics: Aged; Analgesics, Opioid; Analysis of Variance; Anesthetics, Local; Arthroplasty, Replacement, Knee; | 2004 |
Soft tissue and intra-articular injection of bupivacaine, epinephrine, and morphine has a beneficial effect after total knee arthroplasty.
Topics: Aged; Analgesics, Opioid; Analysis of Variance; Anesthetics, Local; Arthroplasty, Replacement, Knee; | 2004 |
Soft tissue and intra-articular injection of bupivacaine, epinephrine, and morphine has a beneficial effect after total knee arthroplasty.
Topics: Aged; Analgesics, Opioid; Analysis of Variance; Anesthetics, Local; Arthroplasty, Replacement, Knee; | 2004 |
Soft tissue and intra-articular injection of bupivacaine, epinephrine, and morphine has a beneficial effect after total knee arthroplasty.
Topics: Aged; Analgesics, Opioid; Analysis of Variance; Anesthetics, Local; Arthroplasty, Replacement, Knee; | 2004 |
Soft tissue and intra-articular injection of bupivacaine, epinephrine, and morphine has a beneficial effect after total knee arthroplasty.
Topics: Aged; Analgesics, Opioid; Analysis of Variance; Anesthetics, Local; Arthroplasty, Replacement, Knee; | 2004 |
Soft tissue and intra-articular injection of bupivacaine, epinephrine, and morphine has a beneficial effect after total knee arthroplasty.
Topics: Aged; Analgesics, Opioid; Analysis of Variance; Anesthetics, Local; Arthroplasty, Replacement, Knee; | 2004 |
Soft tissue and intra-articular injection of bupivacaine, epinephrine, and morphine has a beneficial effect after total knee arthroplasty.
Topics: Aged; Analgesics, Opioid; Analysis of Variance; Anesthetics, Local; Arthroplasty, Replacement, Knee; | 2004 |
Soft tissue and intra-articular injection of bupivacaine, epinephrine, and morphine has a beneficial effect after total knee arthroplasty.
Topics: Aged; Analgesics, Opioid; Analysis of Variance; Anesthetics, Local; Arthroplasty, Replacement, Knee; | 2004 |
Soft tissue and intra-articular injection of bupivacaine, epinephrine, and morphine has a beneficial effect after total knee arthroplasty.
Topics: Aged; Analgesics, Opioid; Analysis of Variance; Anesthetics, Local; Arthroplasty, Replacement, Knee; | 2004 |
Soft tissue and intra-articular injection of bupivacaine, epinephrine, and morphine has a beneficial effect after total knee arthroplasty.
Topics: Aged; Analgesics, Opioid; Analysis of Variance; Anesthetics, Local; Arthroplasty, Replacement, Knee; | 2004 |
Soft tissue and intra-articular injection of bupivacaine, epinephrine, and morphine has a beneficial effect after total knee arthroplasty.
Topics: Aged; Analgesics, Opioid; Analysis of Variance; Anesthetics, Local; Arthroplasty, Replacement, Knee; | 2004 |
Soft tissue and intra-articular injection of bupivacaine, epinephrine, and morphine has a beneficial effect after total knee arthroplasty.
Topics: Aged; Analgesics, Opioid; Analysis of Variance; Anesthetics, Local; Arthroplasty, Replacement, Knee; | 2004 |
Soft tissue and intra-articular injection of bupivacaine, epinephrine, and morphine has a beneficial effect after total knee arthroplasty.
Topics: Aged; Analgesics, Opioid; Analysis of Variance; Anesthetics, Local; Arthroplasty, Replacement, Knee; | 2004 |
Soft tissue and intra-articular injection of bupivacaine, epinephrine, and morphine has a beneficial effect after total knee arthroplasty.
Topics: Aged; Analgesics, Opioid; Analysis of Variance; Anesthetics, Local; Arthroplasty, Replacement, Knee; | 2004 |
Soft tissue and intra-articular injection of bupivacaine, epinephrine, and morphine has a beneficial effect after total knee arthroplasty.
Topics: Aged; Analgesics, Opioid; Analysis of Variance; Anesthetics, Local; Arthroplasty, Replacement, Knee; | 2004 |
Soft tissue and intra-articular injection of bupivacaine, epinephrine, and morphine has a beneficial effect after total knee arthroplasty.
Topics: Aged; Analgesics, Opioid; Analysis of Variance; Anesthetics, Local; Arthroplasty, Replacement, Knee; | 2004 |
Soft tissue and intra-articular injection of bupivacaine, epinephrine, and morphine has a beneficial effect after total knee arthroplasty.
Topics: Aged; Analgesics, Opioid; Analysis of Variance; Anesthetics, Local; Arthroplasty, Replacement, Knee; | 2004 |
Soft tissue and intra-articular injection of bupivacaine, epinephrine, and morphine has a beneficial effect after total knee arthroplasty.
Topics: Aged; Analgesics, Opioid; Analysis of Variance; Anesthetics, Local; Arthroplasty, Replacement, Knee; | 2004 |
Soft tissue and intra-articular injection of bupivacaine, epinephrine, and morphine has a beneficial effect after total knee arthroplasty.
Topics: Aged; Analgesics, Opioid; Analysis of Variance; Anesthetics, Local; Arthroplasty, Replacement, Knee; | 2004 |
Soft tissue and intra-articular injection of bupivacaine, epinephrine, and morphine has a beneficial effect after total knee arthroplasty.
Topics: Aged; Analgesics, Opioid; Analysis of Variance; Anesthetics, Local; Arthroplasty, Replacement, Knee; | 2004 |
Soft tissue and intra-articular injection of bupivacaine, epinephrine, and morphine has a beneficial effect after total knee arthroplasty.
Topics: Aged; Analgesics, Opioid; Analysis of Variance; Anesthetics, Local; Arthroplasty, Replacement, Knee; | 2004 |
[Hypotensive epidural anesthesia in thoracic surgery].
Topics: Adult; Aged; Analgesics, Opioid; Anesthesia, Epidural; Anesthesia, General; Anesthetics, Local; Bloo | 2004 |
[Outpatient external dacryocystorhinostomy under regional anesthesia and sedation].
Topics: Aged; Ambulatory Surgical Procedures; Analgesia; Blood Loss, Surgical; Bupivacaine; Dacryocystorhino | 2007 |
Tumescent technique for liposuction.
Topics: Anesthesia, Local; Blood Loss, Surgical; Bupivacaine; Epinephrine; Humans; Lidocaine; Lipectomy | 1994 |
Anaesthesia for endoluminal repair of abdominal aortic aneurysms.
Topics: Aged; Anesthesia, Epidural; Anesthesia, General; Anesthesia, Spinal; Aortic Aneurysm, Abdominal; Blo | 2002 |
Blood loss reduced during hip arthroplasty by lumbar plexus block.
Topics: Blood Loss, Surgical; Bone Cements; Bupivacaine; Female; Hip Prosthesis; Humans; Lumbosacral Plexus; | 1990 |