bupivacaine has been researched along with Arthritis, Degenerative in 29 studies
Bupivacaine: A widely used local anesthetic agent.
1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide : A piperidinecarboxamide obtained by formal condensation of the carboxy group of N-butylpipecolic acid with the amino group of 2,6-dimethylaniline.
bupivacaine : A racemate composed of equimolar amounts of dextrobupivacaine and levobupivacaine. Used (in the form of its hydrochloride hydrate) as a local anaesthetic.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The postoperative analgesic effects of intra-articular injections of bupivacaine and/or morphine were examined prospectively in 437 patients who had total knee replacement for osteoarthritis." | 5.09 | Intra-articular morphine and/or bupivacaine after total knee replacement. ( Faris, PM; Keating, EM; Koehler, M; Meding, JB; Ritter, MA, 1999) |
| "A double blind randomised trial was carried out to ascertain whether intra-articular injections of saline, bupivacaine or bupivacaine plus triamcinolone would be of value in the relief of hip pain suffered by patients awaiting total hip replacement for osteoarthritis." | 5.06 | Intra-articular injection for pain relief in patients awaiting hip replacement. ( Casale, FF; Desai, KB; Flanagan, J; Thomas, TL, 1988) |
| "The pain relief provided by intra-articular injection of morphine plus bupivacaine after total knee arthroplasty (TKA) plus partial synovectomy in patients with rheumatoid arthritis was compared with pain relief after TKA alone in patients with osteoarthritis." | 3.71 | The efficacy of intra-articular analgesia after total knee arthroplasty in patients with rheumatoid arthritis and in patients with osteoarthritis. ( Hirose, K; Ishii, S; Sakahashi, H; Sato, E; Tanaka, N, 2001) |
| "Morphine has been shown to be an effective intra-articular analgesic, and its anti-inflammatory role seen in this study makes it a potential alternative to bupivacaine." | 1.35 | The effect of bupivacaine and morphine in a coculture model of diarthrodial joints. ( Anz, A; Branson, K; Cook, JL; Linville, C; Markway, H; Smith, MJ; Stoker, A, 2009) |
| "Bupivacaine HCl is a 50:50 racemic mixture of the levo [S(-)] and dex [R(+)] enantiomers." | 1.30 | Arterial and pulmonary arterial concentrations of the enantiomers of bupivacaine after epidural injection in elderly patients. ( Go, G; Mather, LE; Sculco, TP; Sharrock, NE, 1998) |
| "Temporomandibular joint osteoarthrosis is common but typically asymptomatic." | 1.29 | Osteoarthrosis, the temporomandibular joint, and Eagle's syndrome. ( Barrett, AW; Griffiths, MJ; Scully, C, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (27.59) | 18.7374 |
| 1990's | 7 (24.14) | 18.2507 |
| 2000's | 4 (13.79) | 29.6817 |
| 2010's | 9 (31.03) | 24.3611 |
| 2020's | 1 (3.45) | 2.80 |
| Authors | Studies |
|---|---|
| Moser, LB | 1 |
| Bauer, C | 1 |
| Jeyakumar, V | 1 |
| Niculescu-Morzsa, EP | 1 |
| Nehrer, S | 1 |
| Mulligan, RP | 1 |
| Morash, JG | 1 |
| DeOrio, JK | 1 |
| Parekh, SG | 1 |
| Zhao, B | 1 |
| Ma, X | 1 |
| Zhang, J | 1 |
| Ma, J | 1 |
| Cao, Q | 1 |
| Breu, A | 1 |
| Rosenmeier, K | 1 |
| Kujat, R | 1 |
| Angele, P | 1 |
| Zink, W | 1 |
| Chan, EY | 1 |
| Teo, YH | 1 |
| Assam, PN | 1 |
| Fransen, M | 1 |
| Barry, SL | 1 |
| Martinez, SA | 1 |
| Davies, NM | 1 |
| Remsberg, CM | 1 |
| Sayre, CL | 1 |
| Bachelez, A | 1 |
| Herbst, SA | 1 |
| Kim, T | 1 |
| Seol, DR | 1 |
| Hahm, SC | 1 |
| Ko, C | 1 |
| Kim, EH | 1 |
| Chun, K | 1 |
| Kim, J | 1 |
| Lim, TH | 1 |
| Khanna, A | 1 |
| Saxena, R | 1 |
| Dutta, A | 1 |
| Ganguly, N | 1 |
| Sood, J | 1 |
| Anz, A | 1 |
| Smith, MJ | 1 |
| Stoker, A | 1 |
| Linville, C | 1 |
| Markway, H | 1 |
| Branson, K | 1 |
| Cook, JL | 1 |
| Lareau, JM | 1 |
| Robbins, CE | 1 |
| Talmo, CT | 1 |
| Mehio, AK | 1 |
| Puri, L | 1 |
| Bono, JV | 1 |
| Soltesz, EG | 1 |
| van Pelt, F | 1 |
| Byrne, JG | 1 |
| Harmon, D | 1 |
| Hearty, C | 1 |
| Coates, DP | 1 |
| Sanders, R | 1 |
| Edmonds-Seal, J | 1 |
| Barrett, AW | 1 |
| Griffiths, MJ | 1 |
| Scully, C | 1 |
| Hopper, JM | 1 |
| Carter, SR | 1 |
| Spruit, M | 1 |
| Van Goethem, CJ | 1 |
| Kooijman, MA | 1 |
| Pavlov, PW | 1 |
| Sharrock, NE | 1 |
| Mather, LE | 1 |
| Go, G | 1 |
| Sculco, TP | 1 |
| Crawford, RW | 1 |
| Gie, GA | 1 |
| Ling, RS | 1 |
| Murray, DW | 1 |
| Ritter, MA | 1 |
| Koehler, M | 1 |
| Keating, EM | 1 |
| Faris, PM | 1 |
| Meding, JB | 1 |
| Tanaka, N | 1 |
| Sakahashi, H | 1 |
| Sato, E | 1 |
| Hirose, K | 1 |
| Ishii, S | 1 |
| Fernandes, L | 1 |
| Goodwill, CJ | 1 |
| Wright, MG | 1 |
| James, CD | 1 |
| Little, TF | 1 |
| Lamer, TJ | 1 |
| Flanagan, J | 1 |
| Casale, FF | 1 |
| Thomas, TL | 1 |
| Desai, KB | 1 |
| Wulf, H | 1 |
| Winckler, K | 1 |
| Denzer, D | 1 |
| Bogduk, N | 1 |
| Marsland, A | 1 |
| Hannington-Kiff, JG | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| On Postoperative Analgesic Requirements in Laparoscopic Colorectal Surgery Patients After Exparel Administration Via Transversus Abdominis Plane Block Versus Surgical Infiltration[NCT03927326] | 150 participants (Anticipated) | Interventional | 2019-08-31 | Not yet recruiting | |||
| Does the Addition of Liposomal Bupivacaine to the Adductor Canal Block Impact Narcotic Use After Primary Total Knee Arthroplasty: a Prospective, Blind Randomized Control Trial[NCT04539730] | Phase 4 | 0 participants (Actual) | Interventional | 2021-12-01 | Withdrawn (stopped due to Did not acquire funding to pursue study) | ||
| Effects of Continuous Femoral Nerve Block Versus Single-Injection Femoral Nerve Block With Intravenous Patient Controlled Analgesia Versus Intravenous Patient Controlled Analgesia on Knee Pain and Function After Total Knee Replacement[NCT01187537] | 200 participants (Actual) | Interventional | 2009-07-31 | Completed | |||
| Does the Use of Liposomal Bupivacaine Decrease Narcotic Requirements in Geriatric Hip Fractures? A Randomized, Double Blinded Control Trial[NCT03289858] | Phase 4 | 55 participants (Actual) | Interventional | 2017-09-01 | Completed | ||
| A Prospective, Randomized Trial Evaluating Regional Anesthesia, Long-Acting Local Anesthesia, and Traditional Care for Pain Control of Operatively Treated Ankle Fractures[NCT03696199] | Phase 4 | 70 participants (Anticipated) | Interventional | 2020-09-01 | Recruiting | ||
| Comparison of the Effect of Intra-articular Administration of 2% Ropivacaine vs. 7.5% Ropivacaine as an Analgesic in the Immediate Postoperative Period of Knee Arthroscopy in Acute Injuries at the ABC Medical Center[NCT05807945] | Phase 4 | 68 participants (Actual) | Interventional | 2020-04-01 | Completed | ||
| The Role of Intra-Operative Intracapsular Blocks in Post-Operative Pain Management Following Total Knee Arthroplasty: A Double-Blinded Randomized Controlled Trial[NCT00620828] | Phase 4 | 67 participants (Actual) | Interventional | 2007-05-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Morphine meq given (NCT03289858)
Timeframe: 72 hours
| Intervention | Morphine mEq (Mean) |
|---|---|
| Exparel (Liposomal Bupivacaine) | 52.5 |
| Saline Control | 65.39 |
Ambulation distance walked by participants 24-hours post-operatively (NCT00620828)
Timeframe: 24 hours post-op
| Intervention | Feet (Median) |
|---|---|
| Block Group | 38.4 |
| Control Group | 26.4 |
Participants were asked to rate their pain on a scale of 0 to 10 at all time intervals up to 24 hours post-injection. Scores were organized into the following categories: 3 or less (mild pain), 4 to 6 (moderate pain), 7 or higher (severe pain). (NCT00620828)
Timeframe: Post-anesthesia care unit (PACU), 4 hours, 8 hours, 12 hours and 24 hours post-injection
| Intervention | units on a scale (Mean) | ||||
|---|---|---|---|---|---|
| PACU | 4 hours | 8 hours | 12 hours | 24 hours | |
| Block Group | 0.67 | 2.5 | 3.8 | 3.2 | 3.9 |
| Control Group | 1.6 | 3.6 | 4.9 | 3.9 | 4.9 |
Straight Leg Raise (SLR): number of people that can perform a SLR at designated intervals (NCT00620828)
Timeframe: 4 hours, 8 hours, 12 hours and 24 hours post-op
| Intervention | participants (Number) | |||
|---|---|---|---|---|
| SLR 4 hrs | SLR 8 hrs | SLR 12 hrs | SLR 24 hrs | |
| Block Group | 4 | 13 | 12 | 13 |
| Control Group | 5 | 5 | 5 | 6 |
Knee extension and knee flexion measured at 24-hours post-operatively for patient cohort (NCT00620828)
Timeframe: 24 hours post-op
| Intervention | degrees (Mean) | |
|---|---|---|
| Knee extension | Knee flexion | |
| Block Group | 7.8 | 71.5 |
| Control Group | 7.0 | 69.6 |
The PCA total dose at the 4-hour, 8-hour, 12-hour and 24-hour post-operative time points. (NCT00620828)
Timeframe: 4 hours to 24 hours post-op
| Intervention | micrograms (Mean) | |||
|---|---|---|---|---|
| 4 hours | 8 hours | 12 hours | 24 hours | |
| Block Group | 22.4 | 95.6 | 173.4 | 418.5 |
| Control Group | 43.7 | 126.6 | 205.6 | 292.2 |
4 reviews available for bupivacaine and Arthritis, Degenerative
| Article | Year |
|---|---|
The efficacy of local liposomal bupivacaine infiltration on pain and recovery after Total Joint Arthroplasty: A systematic review and meta-analysis of randomized controlled trials.
Topics: Aged; Analgesics, Opioid; Anesthetics, Local; Arthroplasty, Replacement, Knee; Bupivacaine; Female; | 2019 |
Local infiltration of liposome bupivacaine in foot and ankle surgery: case-based reviews.
Topics: Anesthesia, Local; Anesthetics, Local; Ankle Fractures; Ankle Joint; Arthroplasty, Replacement, Ankl | 2014 |
Local infiltration of liposome bupivacaine in foot and ankle surgery: case-based reviews.
Topics: Anesthesia, Local; Anesthetics, Local; Ankle Fractures; Ankle Joint; Arthroplasty, Replacement, Ankl | 2014 |
Local infiltration of liposome bupivacaine in foot and ankle surgery: case-based reviews.
Topics: Anesthesia, Local; Anesthetics, Local; Ankle Fractures; Ankle Joint; Arthroplasty, Replacement, Ankl | 2014 |
Local infiltration of liposome bupivacaine in foot and ankle surgery: case-based reviews.
Topics: Anesthesia, Local; Anesthetics, Local; Ankle Fractures; Ankle Joint; Arthroplasty, Replacement, Ankl | 2014 |
Emergent cardiopulmonary bypass for bupivacaine cardiotoxicity.
Topics: Adult; Anesthetics, Local; Ankle; Arthroplasty; Bupivacaine; Cardiopulmonary Bypass; Emergency Treat | 2003 |
Anaphylaxis after intra-articular injection of bupivacaine and methylprednisolone.
Topics: Anaphylaxis; Bupivacaine; Drug Therapy, Combination; Humans; Injections, Intra-Articular; Knee; Male | 1993 |
6 trials available for bupivacaine and Arthritis, Degenerative
| Article | Year |
|---|---|
Functional discharge readiness and mobility following total knee arthroplasty for osteoarthritis: a comparison of analgesic techniques.
Topics: Aged; Analgesia, Patient-Controlled; Analgesics, Opioid; Arthroplasty, Replacement, Knee; Bupivacain | 2014 |
Comparison of ropivacaine with and without fentanyl vs bupivacaine with fentanyl for postoperative epidural analgesia in bilateral total knee replacement surgery.
Topics: Aged; Amides; Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthetics, L | 2017 |
Diagnostic infiltration of the hip joint with bupivacain in adult acetabular dysplasia.
Topics: Acetabulum; Adolescent; Adult; Analysis of Variance; Anesthetics, Local; Bupivacaine; Chi-Square Dis | 1997 |
Intra-articular morphine and/or bupivacaine after total knee replacement.
Topics: Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Anesthetics, Local; Arthroplasty, Replacement; B | 1999 |
Local anaesthetic nerve block in the treatment of intractable pain from osteoarthritis of the hip.
Topics: Aged; Anesthesia, Local; Bupivacaine; Clinical Trials as Topic; Double-Blind Method; Female; Hip Joi | 1978 |
Intra-articular injection for pain relief in patients awaiting hip replacement.
Topics: Aged; Bupivacaine; Clinical Trials as Topic; Double-Blind Method; Drug Therapy, Combination; Female; | 1988 |
19 other studies available for bupivacaine and Arthritis, Degenerative
| Article | Year |
|---|---|
Hyaluronic Acid as a Carrier Supports the Effects of Glucocorticoids and Diminishes the Cytotoxic Effects of Local Anesthetics in Human Articular Chondrocytes In Vitro.
Topics: Anesthetics, Local; Bupivacaine; Cell Survival; Cells, Cultured; Chondrocytes; Drug Therapy, Combina | 2021 |
Liposomal Bupivacaine Versus Continuous Popliteal Sciatic Nerve Block in Total Ankle Arthroplasty.
Topics: Aged; Arthroplasty, Replacement, Ankle; Bupivacaine; Cohort Studies; Female; Follow-Up Studies; Huma | 2017 |
The cytotoxicity of bupivacaine, ropivacaine, and mepivacaine on human chondrocytes and cartilage.
Topics: Adult; Amides; Anesthetics, Local; Apoptosis; Bupivacaine; Cartilage; Caspases; Cell Survival; Cells | 2013 |
Synovial fluid bupivacaine concentrations following single intra-articular injection in normal and osteoarthritic canine stifles.
Topics: Anesthetics, Local; Animals; Bupivacaine; Case-Control Studies; Dog Diseases; Dogs; Injections, Intr | 2015 |
Analgesic Effect of Intra-Articular Injection of Temperature-Responsive Hydrogel Containing Bupivacaine on Osteoarthritic Pain in Rats.
Topics: Analgesics; Anesthetics, Local; Animals; Arthralgia; Behavior, Animal; Bupivacaine; Chronic Pain; Di | 2015 |
The effect of bupivacaine and morphine in a coculture model of diarthrodial joints.
Topics: Analgesics, Opioid; Anesthetics, Local; Animals; Body Water; Bupivacaine; Cartilage, Articular; Cell | 2009 |
Complications of femoral nerve blockade in total knee arthroplasty and strategies to reduce patient risk.
Topics: Aged; Anesthetics, Local; Arthroplasty, Replacement, Knee; Bupivacaine; Catheters; Compartment Syndr | 2012 |
Ultrasound-guided suprascapular nerve block technique.
Topics: Adult; Anesthesia, Local; Anesthetics, Local; Arthralgia; Brachial Plexus; Bupivacaine; Humans; Levo | 2007 |
Regional hip blockade.
Topics: Aged; Bupivacaine; Hip Joint; Humans; Nerve Block; Osteoarthritis; Pain, Intractable | 1983 |
Convulsions following regional hip blockade with bupivacaine and adrenaline.
Topics: Aged; Bupivacaine; Epinephrine; Female; Hip; Humans; Male; Middle Aged; Nerve Block; Obturator Nerve | 1983 |
Osteoarthrosis, the temporomandibular joint, and Eagle's syndrome.
Topics: Adult; Bupivacaine; Facial Pain; Female; Humans; Methylprednisolone; Occlusal Splints; Osteoarthriti | 1993 |
Arterial and pulmonary arterial concentrations of the enantiomers of bupivacaine after epidural injection in elderly patients.
Topics: Absorption; Aged; Anesthesia, Epidural; Anesthetics, Local; Area Under Curve; Arthroplasty, Replacem | 1998 |
Diagnostic value of intra-articular anaesthetic in primary osteoarthritis of the hip.
Topics: Anesthetics, Local; Arthroplasty, Replacement, Hip; Bupivacaine; Female; Follow-Up Studies; Hip Join | 1998 |
The efficacy of intra-articular analgesia after total knee arthroplasty in patients with rheumatoid arthritis and in patients with osteoarthritis.
Topics: Analgesia; Analgesics, Opioid; Anesthetics, Local; Arthritis, Rheumatoid; Arthroplasty, Replacement, | 2001 |
Regional hip blockade. A simplified technique for the relief of intractable osteoarthritic pain.
Topics: Autonomic Nerve Block; Bupivacaine; Hip Joint; Humans; Obturator Nerve; Osteoarthritis; Pain, Intrac | 1976 |
Ear pain due to cervical spine arthritis: treatment with cervical facet injection.
Topics: Aged; Bupivacaine; Cervical Vertebrae; Delayed-Action Preparations; Earache; Female; Humans; Injecti | 1991 |
Plasma concentrations of alpha-1-acid glycoprotein following operations and its effect on the plasma protein binding of bupivacaine.
Topics: Arthritis, Rheumatoid; Bupivacaine; Hip Prosthesis; Humans; Middle Aged; Orosomucoid; Osteoarthritis | 1989 |
On the concept of third occipital headache.
Topics: Adult; Axis, Cervical Vertebra; Bupivacaine; Cervical Vertebrae; Female; Headache; Humans; Male; Mid | 1986 |
Treatment of intractable pain by bupivacaine nerve-block.
Topics: Aged; Analgesia; Anesthesia, Conduction; Anesthetics, Local; Bupivacaine; Female; Humans; Male; Midd | 1971 |